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Conserved domains on  [gi|1754759076|ref|NP_001361415|]
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GPI mannosyltransferase 2 isoform d [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PMT_2 super family cl21590
Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are ...
 12-119 4.08e-17

Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are not captured by pfam02366.


The actual alignment was detected with superfamily member pfam04188:

Pssm-ID: 473917  Cd Length: 439  Bit Score: 75.33  E-value: 4.08e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1754759076  12 LRFAVSCRILTLMLQVLTRFLgSSTPIMYWFPAHLLQdqepllrSLKTVPWKPLAEDsppgqkvprnPIMGLLYHWKTCS 91
Cdd:pfam04188 361 TRALVVIVCFFMHVQVLTRFL-SFLPLHYWFLADLLV-------SDKKKMWNPLGDD----------KIVKFYIYWLACS 422

                          90       100
                  ....*....|....*....|....*...
gi 1754759076  92 pvtryilgyflTYWLLGLLLHCNFLPWT 119
Cdd:pfam04188 423 -----------FYILLGTLLFANFLPPT 439
 
Name Accession Description Interval E-value
Mannosyl_trans2 pfam04188
Mannosyltransferase (PIG-V); This is a family of eukaryotic ER membrane proteins that are ...
 12-119 4.08e-17

Mannosyltransferase (PIG-V); This is a family of eukaryotic ER membrane proteins that are involved in the synthesis of glycosylphosphatidylinositol (GPI), a glycolipid that anchors many proteins to the eukaryotic cell surface. Proteins in this family are involved in transferring the second mannose in the biosynthetic pathway of GPI.


Pssm-ID: 282094  Cd Length: 439  Bit Score: 75.33  E-value: 4.08e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1754759076  12 LRFAVSCRILTLMLQVLTRFLgSSTPIMYWFPAHLLQdqepllrSLKTVPWKPLAEDsppgqkvprnPIMGLLYHWKTCS 91
Cdd:pfam04188 361 TRALVVIVCFFMHVQVLTRFL-SFLPLHYWFLADLLV-------SDKKKMWNPLGDD----------KIVKFYIYWLACS 422

                          90       100
                  ....*....|....*....|....*...
gi 1754759076  92 pvtryilgyflTYWLLGLLLHCNFLPWT 119
Cdd:pfam04188 423 -----------FYILLGTLLFANFLPPT 439
 
Name Accession Description Interval E-value
Mannosyl_trans2 pfam04188
Mannosyltransferase (PIG-V); This is a family of eukaryotic ER membrane proteins that are ...
 12-119 4.08e-17

Mannosyltransferase (PIG-V); This is a family of eukaryotic ER membrane proteins that are involved in the synthesis of glycosylphosphatidylinositol (GPI), a glycolipid that anchors many proteins to the eukaryotic cell surface. Proteins in this family are involved in transferring the second mannose in the biosynthetic pathway of GPI.


Pssm-ID: 282094  Cd Length: 439  Bit Score: 75.33  E-value: 4.08e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1754759076  12 LRFAVSCRILTLMLQVLTRFLgSSTPIMYWFPAHLLQdqepllrSLKTVPWKPLAEDsppgqkvprnPIMGLLYHWKTCS 91
Cdd:pfam04188 361 TRALVVIVCFFMHVQVLTRFL-SFLPLHYWFLADLLV-------SDKKKMWNPLGDD----------KIVKFYIYWLACS 422

                          90       100
                  ....*....|....*....|....*...
gi 1754759076  92 pvtryilgyflTYWLLGLLLHCNFLPWT 119
Cdd:pfam04188 423 -----------FYILLGTLLFANFLPPT 439
Mannosyl_trans2 pfam04188
Mannosyltransferase (PIG-V); This is a family of eukaryotic ER membrane proteins that are ...
 8-32 6.92e-03

Mannosyltransferase (PIG-V); This is a family of eukaryotic ER membrane proteins that are involved in the synthesis of glycosylphosphatidylinositol (GPI), a glycolipid that anchors many proteins to the eukaryotic cell surface. Proteins in this family are involved in transferring the second mannose in the biosynthetic pathway of GPI.


Pssm-ID: 282094  Cd Length: 439  Bit Score: 34.89  E-value: 6.92e-03
                          10        20
                  ....*....|....*....|....*
gi 1754759076   8 RKEVLRFAVSCRILTLMLQVLTRFL 32
Cdd:pfam04188   1 IKELTLYAVLFRSLQLLLVFLTPIR 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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