NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1750897562|ref|NP_001361309|]
View 

fumarylacetoacetase [Homo sapiens]

Protein Classification

fumarylacetoacetase( domain architecture ID 11492172)

fumarylacetoacetase converts fumarylacetoacetate to acetoacetate and fumarate

EC:  3.7.1.2
Gene Symbol:  FAH
Gene Ontology:  GO:0004334|GO:0046872
PubMed:  29487229
SCOP:  4002580

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
fum_ac_acetase TIGR01266
fumarylacetoacetase; This enzyme catalyzes the final step in the breakdown of tyrosine or ...
2-416 0e+00

fumarylacetoacetase; This enzyme catalyzes the final step in the breakdown of tyrosine or phenylalanine to fumarate and acetoacetate. [Energy metabolism, Amino acids and amines]


:

Pssm-ID: 162276 [Multi-domain]  Cd Length: 415  Bit Score: 807.92  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750897562   2 SFIPVAEDSDFPIHNLPYGVFSTRGDPRPRIGVAIGDQILDLSIIKHLFTGPVLSKHQDVFNQPTLNSFMGLGQAAWKEA 81
Cdd:TIGR01266   1 SFVPVAENSDFPIQNLPYGVFSTQANSSPRIGVAIGDQILDLSVIAHLFTGPALSKHQHVFDQSTLNAFMALGRPAWKEA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750897562  82 RVFLQNLLSVSQARLRDDTELRKCAFISQASATMHLPATIGDYTDFYSSRQHATNVGIMFRDKENALMPNWLHLPVGYHG 161
Cdd:TIGR01266  81 RARLQNLLSASQARLRDNAALRQRALTPQAEATMHLPAQIGDYTDFYSSIQHATNVGIMFRGKENALLPNWKHLPVGYHG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750897562 162 RASSVVVSGTPIRRPMGQMKPDDSKPPVYGACKLLDMELEMAFFVGPGNRLGEPIPISKAHEHIFGMVLMNDWSARDIQK 241
Cdd:TIGR01266 161 RASSIVVSGTPLRRPMGQTLPDNAKPPVFGPCKLLDMELEMAFFVGPGNRLGEPIPISKAEEHIFGVVLMNDWSARDIQA 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750897562 242 WEYVPLGPFLGKSFGTTVSPWVVPMDALMPFAVPNPKQDPRPLPYLCHDEPYTFDINLSVNLKGEGMSQAATICKSNFKY 321
Cdd:TIGR01266 241 WEYVPLGPFLAKSFGTTISPWVVPIDALEPFRVPNPKQDPKPLPYLCHDAPYTFDINLEVSLKGEGMSEPATICRSNFKH 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750897562 322 MYWTMLQQLTHHSVNGCNLRPGDLLASGTISGPEPENFGSMLELSWKGTKPIDLGNGQTRKFLLDGDEVIITGYCQGDGY 401
Cdd:TIGR01266 321 MYWTMLQQLAHHSVNGCNLRPGDLLGSGTISGSEPGSFGSMLELSWKGKKPIDVAQGETRTFLEDGDEVILRGHCQGEGY 400
                         410
                  ....*....|....*
gi 1750897562 402 RIGFGQCAGKVLPAL 416
Cdd:TIGR01266 401 RVGFGECAGKVLPAL 415
 
Name Accession Description Interval E-value
fum_ac_acetase TIGR01266
fumarylacetoacetase; This enzyme catalyzes the final step in the breakdown of tyrosine or ...
2-416 0e+00

fumarylacetoacetase; This enzyme catalyzes the final step in the breakdown of tyrosine or phenylalanine to fumarate and acetoacetate. [Energy metabolism, Amino acids and amines]


Pssm-ID: 162276 [Multi-domain]  Cd Length: 415  Bit Score: 807.92  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750897562   2 SFIPVAEDSDFPIHNLPYGVFSTRGDPRPRIGVAIGDQILDLSIIKHLFTGPVLSKHQDVFNQPTLNSFMGLGQAAWKEA 81
Cdd:TIGR01266   1 SFVPVAENSDFPIQNLPYGVFSTQANSSPRIGVAIGDQILDLSVIAHLFTGPALSKHQHVFDQSTLNAFMALGRPAWKEA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750897562  82 RVFLQNLLSVSQARLRDDTELRKCAFISQASATMHLPATIGDYTDFYSSRQHATNVGIMFRDKENALMPNWLHLPVGYHG 161
Cdd:TIGR01266  81 RARLQNLLSASQARLRDNAALRQRALTPQAEATMHLPAQIGDYTDFYSSIQHATNVGIMFRGKENALLPNWKHLPVGYHG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750897562 162 RASSVVVSGTPIRRPMGQMKPDDSKPPVYGACKLLDMELEMAFFVGPGNRLGEPIPISKAHEHIFGMVLMNDWSARDIQK 241
Cdd:TIGR01266 161 RASSIVVSGTPLRRPMGQTLPDNAKPPVFGPCKLLDMELEMAFFVGPGNRLGEPIPISKAEEHIFGVVLMNDWSARDIQA 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750897562 242 WEYVPLGPFLGKSFGTTVSPWVVPMDALMPFAVPNPKQDPRPLPYLCHDEPYTFDINLSVNLKGEGMSQAATICKSNFKY 321
Cdd:TIGR01266 241 WEYVPLGPFLAKSFGTTISPWVVPIDALEPFRVPNPKQDPKPLPYLCHDAPYTFDINLEVSLKGEGMSEPATICRSNFKH 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750897562 322 MYWTMLQQLTHHSVNGCNLRPGDLLASGTISGPEPENFGSMLELSWKGTKPIDLGNGQTRKFLLDGDEVIITGYCQGDGY 401
Cdd:TIGR01266 321 MYWTMLQQLAHHSVNGCNLRPGDLLGSGTISGSEPGSFGSMLELSWKGKKPIDVAQGETRTFLEDGDEVILRGHCQGEGY 400
                         410
                  ....*....|....*
gi 1750897562 402 RIGFGQCAGKVLPAL 416
Cdd:TIGR01266 401 RVGFGECAGKVLPAL 415
PLN02856 PLN02856
fumarylacetoacetase
2-416 0e+00

fumarylacetoacetase


Pssm-ID: 215461 [Multi-domain]  Cd Length: 424  Bit Score: 721.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750897562   2 SFIPVAEDSDFPIHNLPYGVFSTRGDPRPRIGVAIGDQILDLSIIKH--LFTGPVLSKhQDVFNQPTLNSFMGLGQAAWK 79
Cdd:PLN02856    7 SFIDVAPDSDFPIQNLPYGVFSPESGATPRPGVAIGDYVLDLSALSEagLFDGPLLSD-SDCFSQPTLNKFMAMGRPAWK 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750897562  80 EARVFLQNLLSVSQARLRDDTELRKCAFISQASATMHLPATIGDYTDFYSSRQHATNVGIMFRDKENALMPNWLHLPVGY 159
Cdd:PLN02856   86 EARSTLQRLLSADEPALRDNSELRKKAFHPMSDVEMLLPAVIGDYTDFFSSREHATNVGTMFRGPENALNPNWLHLPIGY 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750897562 160 HGRASSVVVSGTPIRRPMGQMKPDD-SKPPVYGACKLLDMELEMAFFVGPGNRLGEPIPISKAHEHIFGMVLMNDWSARD 238
Cdd:PLN02856  166 HGRASSVVPSGTDIRRPRGQLHPNDgSSRPYFGPSAKLDFELEMAAFVGPGNELGKPIPVNEAKDHIFGLVLMNDWSARD 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750897562 239 IQKWEYVPLGPFLGKSFGTTVSPWVVPMDALMPFAVPNPKQDPRPLPYLCHDEPYTFDINLSVNLKGEGMSQAATICKSN 318
Cdd:PLN02856  246 IQKWEYVPLGPFLGKSFATTISPWIVTLDALEPFRCDAPAQDPPPLPYLAEKNRKSYDISLEVAIKPAGQSKASVVCRSN 325
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750897562 319 FKYMYWTMLQQLTHHSVNGCNLRPGDLLASGTISGPEPENFGSMLELSWKGTKPIDLGNGQTRKFLLDGDEVIITGYCQG 398
Cdd:PLN02856  326 FKHLYWTLAQQLAHHTVNGCNLRPGDLLGSGTISGPEPGSLGCLLELTWAGSREVSLEGGTRRKFLEDGDEVVLSGWCKG 405
                         410
                  ....*....|....*...
gi 1750897562 399 DGYRIGFGQCAGKVLPAL 416
Cdd:PLN02856  406 DGYRVGFGTCSGKVLPAL 423
FAA_hydrolase_N pfam09298
Fumarylacetoacetase N-terminal; The N-terminal domain of fumarylacetoacetate hydrolase is ...
15-118 3.57e-47

Fumarylacetoacetase N-terminal; The N-terminal domain of fumarylacetoacetate hydrolase is functionally uncharacterized, and adopts a structure consisting of an SH3-like barrel.


Pssm-ID: 462748 [Multi-domain]  Cd Length: 104  Bit Score: 156.92  E-value: 3.57e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750897562  15 HNLPYGVFSTRGDPRPRIGVAIGDQILDLSIIKH--LFTGpVLSKHQDVFNQPTLNSFMGLGQAAWKEARVFLQNLLSVS 92
Cdd:pfam09298   1 QNLPFGVFSTAGSPTPRIGVAIGDQVLDLSALAAagLFDG-IAQLALDVFSQPTLNAFMALGRPVWRAVRARLQELLSAP 79
                          90       100
                  ....*....|....*....|....*.
gi 1750897562  93 qARLRDDTELRKCAFISQASATMHLP 118
Cdd:pfam09298  80 -PVLRDNAELREKALVPQADVTMHLP 104
YcgM COG0179
2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) ...
163-353 1.94e-15

2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 439949  Cd Length: 206  Bit Score: 74.72  E-value: 1.94e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750897562 163 ASSVVVSGTPIRRPmgqmkpddskppvyGACKLLDMELEMAFFVGpgnRLGEPIPISKAHEHIFGMVLMNDWSARDIQKW 242
Cdd:COG0179    37 PSALVGPGDPIPLP--------------AGSGKLDYEGELAVVIG---KRARNVSEEDALDHVAGYTVANDVTARDLQRE 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750897562 243 EYVPLgpFLGKSFGTT--VSPWVVPMDALmpfavpnpkQDPRPLpylchdepytfDINLSVNlkGEGMSQAATicksnfK 320
Cdd:COG0179   100 RGGQW--TRGKSFDTFcpLGPWIVTADEI---------PDPQDL-----------RIRLRVN--GEVRQDGNT------S 149
                         170       180       190
                  ....*....|....*....|....*....|...
gi 1750897562 321 YMYWTMLQQLTHHSvNGCNLRPGDLLASGTISG 353
Cdd:COG0179   150 DMIFSVAELIAYLS-QFMTLEPGDVILTGTPAG 181
 
Name Accession Description Interval E-value
fum_ac_acetase TIGR01266
fumarylacetoacetase; This enzyme catalyzes the final step in the breakdown of tyrosine or ...
2-416 0e+00

fumarylacetoacetase; This enzyme catalyzes the final step in the breakdown of tyrosine or phenylalanine to fumarate and acetoacetate. [Energy metabolism, Amino acids and amines]


Pssm-ID: 162276 [Multi-domain]  Cd Length: 415  Bit Score: 807.92  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750897562   2 SFIPVAEDSDFPIHNLPYGVFSTRGDPRPRIGVAIGDQILDLSIIKHLFTGPVLSKHQDVFNQPTLNSFMGLGQAAWKEA 81
Cdd:TIGR01266   1 SFVPVAENSDFPIQNLPYGVFSTQANSSPRIGVAIGDQILDLSVIAHLFTGPALSKHQHVFDQSTLNAFMALGRPAWKEA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750897562  82 RVFLQNLLSVSQARLRDDTELRKCAFISQASATMHLPATIGDYTDFYSSRQHATNVGIMFRDKENALMPNWLHLPVGYHG 161
Cdd:TIGR01266  81 RARLQNLLSASQARLRDNAALRQRALTPQAEATMHLPAQIGDYTDFYSSIQHATNVGIMFRGKENALLPNWKHLPVGYHG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750897562 162 RASSVVVSGTPIRRPMGQMKPDDSKPPVYGACKLLDMELEMAFFVGPGNRLGEPIPISKAHEHIFGMVLMNDWSARDIQK 241
Cdd:TIGR01266 161 RASSIVVSGTPLRRPMGQTLPDNAKPPVFGPCKLLDMELEMAFFVGPGNRLGEPIPISKAEEHIFGVVLMNDWSARDIQA 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750897562 242 WEYVPLGPFLGKSFGTTVSPWVVPMDALMPFAVPNPKQDPRPLPYLCHDEPYTFDINLSVNLKGEGMSQAATICKSNFKY 321
Cdd:TIGR01266 241 WEYVPLGPFLAKSFGTTISPWVVPIDALEPFRVPNPKQDPKPLPYLCHDAPYTFDINLEVSLKGEGMSEPATICRSNFKH 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750897562 322 MYWTMLQQLTHHSVNGCNLRPGDLLASGTISGPEPENFGSMLELSWKGTKPIDLGNGQTRKFLLDGDEVIITGYCQGDGY 401
Cdd:TIGR01266 321 MYWTMLQQLAHHSVNGCNLRPGDLLGSGTISGSEPGSFGSMLELSWKGKKPIDVAQGETRTFLEDGDEVILRGHCQGEGY 400
                         410
                  ....*....|....*
gi 1750897562 402 RIGFGQCAGKVLPAL 416
Cdd:TIGR01266 401 RVGFGECAGKVLPAL 415
PLN02856 PLN02856
fumarylacetoacetase
2-416 0e+00

fumarylacetoacetase


Pssm-ID: 215461 [Multi-domain]  Cd Length: 424  Bit Score: 721.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750897562   2 SFIPVAEDSDFPIHNLPYGVFSTRGDPRPRIGVAIGDQILDLSIIKH--LFTGPVLSKhQDVFNQPTLNSFMGLGQAAWK 79
Cdd:PLN02856    7 SFIDVAPDSDFPIQNLPYGVFSPESGATPRPGVAIGDYVLDLSALSEagLFDGPLLSD-SDCFSQPTLNKFMAMGRPAWK 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750897562  80 EARVFLQNLLSVSQARLRDDTELRKCAFISQASATMHLPATIGDYTDFYSSRQHATNVGIMFRDKENALMPNWLHLPVGY 159
Cdd:PLN02856   86 EARSTLQRLLSADEPALRDNSELRKKAFHPMSDVEMLLPAVIGDYTDFFSSREHATNVGTMFRGPENALNPNWLHLPIGY 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750897562 160 HGRASSVVVSGTPIRRPMGQMKPDD-SKPPVYGACKLLDMELEMAFFVGPGNRLGEPIPISKAHEHIFGMVLMNDWSARD 238
Cdd:PLN02856  166 HGRASSVVPSGTDIRRPRGQLHPNDgSSRPYFGPSAKLDFELEMAAFVGPGNELGKPIPVNEAKDHIFGLVLMNDWSARD 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750897562 239 IQKWEYVPLGPFLGKSFGTTVSPWVVPMDALMPFAVPNPKQDPRPLPYLCHDEPYTFDINLSVNLKGEGMSQAATICKSN 318
Cdd:PLN02856  246 IQKWEYVPLGPFLGKSFATTISPWIVTLDALEPFRCDAPAQDPPPLPYLAEKNRKSYDISLEVAIKPAGQSKASVVCRSN 325
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750897562 319 FKYMYWTMLQQLTHHSVNGCNLRPGDLLASGTISGPEPENFGSMLELSWKGTKPIDLGNGQTRKFLLDGDEVIITGYCQG 398
Cdd:PLN02856  326 FKHLYWTLAQQLAHHTVNGCNLRPGDLLGSGTISGPEPGSLGCLLELTWAGSREVSLEGGTRRKFLEDGDEVVLSGWCKG 405
                         410
                  ....*....|....*...
gi 1750897562 399 DGYRIGFGQCAGKVLPAL 416
Cdd:PLN02856  406 DGYRVGFGTCSGKVLPAL 423
FAA_hydrolase_N pfam09298
Fumarylacetoacetase N-terminal; The N-terminal domain of fumarylacetoacetate hydrolase is ...
15-118 3.57e-47

Fumarylacetoacetase N-terminal; The N-terminal domain of fumarylacetoacetate hydrolase is functionally uncharacterized, and adopts a structure consisting of an SH3-like barrel.


Pssm-ID: 462748 [Multi-domain]  Cd Length: 104  Bit Score: 156.92  E-value: 3.57e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750897562  15 HNLPYGVFSTRGDPRPRIGVAIGDQILDLSIIKH--LFTGpVLSKHQDVFNQPTLNSFMGLGQAAWKEARVFLQNLLSVS 92
Cdd:pfam09298   1 QNLPFGVFSTAGSPTPRIGVAIGDQVLDLSALAAagLFDG-IAQLALDVFSQPTLNAFMALGRPVWRAVRARLQELLSAP 79
                          90       100
                  ....*....|....*....|....*.
gi 1750897562  93 qARLRDDTELRKCAFISQASATMHLP 118
Cdd:pfam09298  80 -PVLRDNAELREKALVPQADVTMHLP 104
FAA_hydrolase pfam01557
Fumarylacetoacetate (FAA) hydrolase family; This family consists of fumarylacetoacetate (FAA) ...
124-390 5.33e-35

Fumarylacetoacetate (FAA) hydrolase family; This family consists of fumarylacetoacetate (FAA) hydrolase, or fumarylacetoacetate hydrolase (FAH) and it also includes HHDD isomerase/OPET decarboxylase from E. coli strain W. FAA is the last enzyme in the tyrosine catabolic pathway, it hydrolyses fumarylacetoacetate into fumarate and acetoacetate which then join the citric acid cycle. Mutations in FAA cause type I tyrosinemia in humans this is an inherited disorder mainly affecting the liver leading to liver cirrhosis, hepatocellular carcinoma, renal tubular damages and neurologic crises amongst other symptoms. The enzymatic defect causes the toxic accumulation of phenylalanine/tyrosine catabolites. The E. coli W enzyme HHDD isomerase/OPET decarboxylase contains two copies of this domain and functions in fourth and fifth steps of the homoprotocatechuate pathway; here it decarboxylates OPET to HHDD and isomerizes this to OHED. The final products of this pathway are pyruvic acid and succinic semialdehyde. This family also includes various hydratases and 4-oxalocrotonate decarboxylases which are involved in the bacterial meta-cleavage pathways for degradation of aromatic compounds. 2-hydroxypentadienoic acid hydratase encoded by mhpD in E. coli is involved in the phenylpropionic acid pathway of E. coli and catalyzes the conversion of 2-hydroxy pentadienoate to 4-hydroxy-2-keto-pentanoate and uses a Mn2+ co-factor. OHED hydratase encoded by hpcG in E. coli is involved in the homoprotocatechuic acid (HPC) catabolism. XylI in P. putida is a 4-Oxalocrotonate decarboxylase.


Pssm-ID: 460252  Cd Length: 210  Bit Score: 128.56  E-value: 5.33e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750897562 124 YTDFYSSRQHATNVGiMFRDkenalMPNWLHLPVGYHGRASSVVVSGTPIRRPmgqmkpddskppvyGACKLLDMELEMA 203
Cdd:pfam01557   1 VCVGLNYAEHAREAG-KAEP-----VPDFPIPLVLFVKPPSSLIGPGDPIVRP--------------AGVTKLDYEAELA 60
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750897562 204 FFVGpgNRLGEpIPISKAHEHIFGMVLMNDWSARDIQKWEYvPLGPFLGKSF--GTTVSPWVVPMDALmpfavpnpkqdp 281
Cdd:pfam01557  61 VVIG--RPARD-VSPEEALDYIFGYTLANDVSARDLQRREM-PLQWFRGKSFdgFTPLGPWIVTRDEL------------ 124
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750897562 282 rplpylchDEPYTFDINLSVNlkGEGMSqaaticKSNFKYMYWTMLQQLTHHSvNGCNLRPGDLLASGTISGPEPEnfgs 361
Cdd:pfam01557 125 --------PDPGDLRLRLRVN--GEVRQ------DGNTSDMIFSPAELIAHLS-QFMTLRPGDIILTGTPSGVGAG---- 183
                         250       260
                  ....*....|....*....|....*....
gi 1750897562 362 mlelswkgtkpidlgnGQTRKFLLDGDEV 390
Cdd:pfam01557 184 ----------------RAPPVFLKPGDTV 196
YcgM COG0179
2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) ...
163-353 1.94e-15

2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 439949  Cd Length: 206  Bit Score: 74.72  E-value: 1.94e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750897562 163 ASSVVVSGTPIRRPmgqmkpddskppvyGACKLLDMELEMAFFVGpgnRLGEPIPISKAHEHIFGMVLMNDWSARDIQKW 242
Cdd:COG0179    37 PSALVGPGDPIPLP--------------AGSGKLDYEGELAVVIG---KRARNVSEEDALDHVAGYTVANDVTARDLQRE 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750897562 243 EYVPLgpFLGKSFGTT--VSPWVVPMDALmpfavpnpkQDPRPLpylchdepytfDINLSVNlkGEGMSQAATicksnfK 320
Cdd:COG0179   100 RGGQW--TRGKSFDTFcpLGPWIVTADEI---------PDPQDL-----------RIRLRVN--GEVRQDGNT------S 149
                         170       180       190
                  ....*....|....*....|....*....|...
gi 1750897562 321 YMYWTMLQQLTHHSvNGCNLRPGDLLASGTISG 353
Cdd:COG0179   150 DMIFSVAELIAYLS-QFMTLEPGDVILTGTPAG 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH