NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1743668525|ref|NP_001361202|]
View 

transcription factor GATA-4 isoform 3 [Homo sapiens]

Protein Classification

GATA-type transcription factor( domain architecture ID 10078896)

GATA-type transcription factor binds to the DNA consensus sequence [AT]GATA[AG] and may function as a transcription factor/regulator

CATH:  3.30.50.10
Gene Ontology:  GO:0003700|GO:0006357|GO:0008270|GO:0043565
PubMed:  31574210
SCOP:  4003617

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 64-115 2.93e-20

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 80.88  E-value: 2.93e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1743668525  64 SCANCQTTTTTLWRRN-AEGEPVCNACGLYMKLHGVPRPLAMRKEG-IQTRKRK 115
Cdd:cd00202     1 ACSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNRK 54
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 10-60 9.23e-17

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 71.63  E-value: 9.23e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1743668525  10 ECVNCGAMSTPLWRRDG-TGHYLCNACGLYHKMNGINRPLIKPQRRLSASRR 60
Cdd:cd00202     1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRN 52
 
Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 64-115 2.93e-20

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 80.88  E-value: 2.93e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1743668525  64 SCANCQTTTTTLWRRN-AEGEPVCNACGLYMKLHGVPRPLAMRKEG-IQTRKRK 115
Cdd:cd00202     1 ACSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNRK 54
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 10-60 9.23e-17

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 71.63  E-value: 9.23e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1743668525  10 ECVNCGAMSTPLWRRDG-TGHYLCNACGLYHKMNGINRPLIKPQRRLSASRR 60
Cdd:cd00202     1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRN 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
62-109 1.69e-16

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 70.91  E-value: 1.69e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1743668525   62 GLSCANCQTTTTTLWRRNAEGE-PVCNACGLYMKLHGVP-RPLAMRKEGI 109
Cdd:smart00401   3 GRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGLkRPLSLKKDGI 52
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 65-99 3.93e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 61.57  E-value: 3.93e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1743668525  65 CANCQTTTTTLWRRNAEGEP-VCNACGLYMKLHGVP 99
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
6-53 4.10e-13

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 62.05  E-value: 4.10e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1743668525    6 SEGRECVNCGAMSTPLWRRDGTGH-YLCNACGLYHKMNGINRPLIKPQR 53
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGLKRPLSLKK 49
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 11-43 2.91e-11

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 56.56  E-value: 2.91e-11
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1743668525  11 CVNCGAMSTPLWRRDGTGHY-LCNACGLYHKMNG 43
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKG 34
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
13-129 3.94e-07

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 50.25  E-value: 3.94e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743668525  13 NCGAMSTPLWRR-DGTGHYLCNACGLYHKMNGINRPLikPQRRLSASRRVGLSCANCQTTTTTLWRrnaEGEPVCNACGL 91
Cdd:COG5641   303 LTTSTATPLWRRtSDKSSFSCNASGSALKPPGSKRPL--LPKPDPNSKRSNATCMNCSSTPTNKIL---SPPTTSNSPGA 377

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1743668525  92 YMKLHGVPRPLAMRKEGIQTRKRKPKN---LNKSKTPAAPS 129
Cdd:COG5641   378 QVKLPNQTRSTGATKKKITRRRMNSGKipaLSSSMKNPVPK 418
 
Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 64-115 2.93e-20

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 80.88  E-value: 2.93e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1743668525  64 SCANCQTTTTTLWRRN-AEGEPVCNACGLYMKLHGVPRPLAMRKEG-IQTRKRK 115
Cdd:cd00202     1 ACSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNRK 54
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 10-60 9.23e-17

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 71.63  E-value: 9.23e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1743668525  10 ECVNCGAMSTPLWRRDG-TGHYLCNACGLYHKMNGINRPLIKPQRRLSASRR 60
Cdd:cd00202     1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRN 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
62-109 1.69e-16

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 70.91  E-value: 1.69e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1743668525   62 GLSCANCQTTTTTLWRRNAEGE-PVCNACGLYMKLHGVP-RPLAMRKEGI 109
Cdd:smart00401   3 GRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGLkRPLSLKKDGI 52
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 65-99 3.93e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 61.57  E-value: 3.93e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1743668525  65 CANCQTTTTTLWRRNAEGEP-VCNACGLYMKLHGVP 99
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
6-53 4.10e-13

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 62.05  E-value: 4.10e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1743668525    6 SEGRECVNCGAMSTPLWRRDGTGH-YLCNACGLYHKMNGINRPLIKPQR 53
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGLKRPLSLKK 49
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 11-43 2.91e-11

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 56.56  E-value: 2.91e-11
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1743668525  11 CVNCGAMSTPLWRRDGTGHY-LCNACGLYHKMNG 43
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKG 34
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
13-129 3.94e-07

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 50.25  E-value: 3.94e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743668525  13 NCGAMSTPLWRR-DGTGHYLCNACGLYHKMNGINRPLikPQRRLSASRRVGLSCANCQTTTTTLWRrnaEGEPVCNACGL 91
Cdd:COG5641   303 LTTSTATPLWRRtSDKSSFSCNASGSALKPPGSKRPL--LPKPDPNSKRSNATCMNCSSTPTNKIL---SPPTTSNSPGA 377

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1743668525  92 YMKLHGVPRPLAMRKEGIQTRKRKPKN---LNKSKTPAAPS 129
Cdd:COG5641   378 QVKLPNQTRSTGATKKKITRRRMNSGKipaLSSSMKNPVPK 418
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
3-118 4.65e-07

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 49.87  E-value: 4.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743668525   3 DDFSEGRECVNCGAMSTPLWRRD-----GTGHYLCNACGLYHKMNGINRPLIKPQRRLSASRRVGLSCANCQTTT-TTLW 76
Cdd:COG5641   153 DNSNQPHVCSNCKTTSTPLWRRAssessLPGNNLCNACGLYLKLHGSPRAPISLKSDSIKSRSSRSSHNNNDSNGeNANT 232

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1743668525  77 RRNAEGEPVCNACGLYMKLHGvpRPLAMRKEGIQTRKRKPKN 118
Cdd:COG5641   233 ESIGNSSASKLTKSWEERPQG--RQLLSDAGSLSPRSNNPKS 272
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
61-135 1.02e-06

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 48.71  E-value: 1.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743668525  61 VGLSCANCQTTTTTLWRR-----NAEGEPVCNACGLYMKLHGVPR-PLAMRKEGIQTR-KRKPKNLNKSKtpAAPSGSES 133
Cdd:COG5641   157 QPHVCSNCKTTSTPLWRRassesSLPGNNLCNACGLYLKLHGSPRaPISLKSDSIKSRsSRSSHNNNDSN--GENANTES 234


                  ..
gi 1743668525 134 LP 135
Cdd:COG5641   235 IG 236
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH