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Conserved domains on  [gi|1734342184|ref|NP_001359511|]
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uncharacterized protein LOC108167848 isoform 2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
376-572 2.12e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 2.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734342184 376 CQQSKLVVSQPAPTQEKRYVCNVCGKAFYKRAHLHAHQRTHTG-EKPYDCQECGKSFRLKSFLVVHQR--IHTGE--KPF 450
Cdd:COG5048   243 QSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPF 322

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734342184 451 ACD--TCGKSFKQRTSLYTHIRIHTGEKPYECKECR-------KSFILKSYLTVHQRTHSGEKPYECDV--CGKSFKQNS 519
Cdd:COG5048   323 SCPysLCGKLFSRNDALKRHILLHTSISPAKEKLLNssskfspLLNNEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDS 402

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1734342184 520 HLHAHKRTHTSEKPYEC--IVCGKSYKQSPSLYTHKKIHTSEKPYECKQCRKSFS 572
Cdd:COG5048   403 NLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
KRAB super family cl42959
krueppel associated box;
1-31 5.75e-08

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 49.51  E-value: 5.75e-08
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1734342184    1 MLETYSSLLSLNQCDAKPELILKLEKEAEPW 31
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 562-584 5.57e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 5.57e-03
                          10        20
                  ....*....|....*....|...
gi 1734342184 562 YECKQCRKSFSLKFHLTRHQRTH 584
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
376-572 2.12e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 2.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734342184 376 CQQSKLVVSQPAPTQEKRYVCNVCGKAFYKRAHLHAHQRTHTG-EKPYDCQECGKSFRLKSFLVVHQR--IHTGE--KPF 450
Cdd:COG5048   243 QSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPF 322

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734342184 451 ACD--TCGKSFKQRTSLYTHIRIHTGEKPYECKECR-------KSFILKSYLTVHQRTHSGEKPYECDV--CGKSFKQNS 519
Cdd:COG5048   323 SCPysLCGKLFSRNDALKRHILLHTSISPAKEKLLNssskfspLLNNEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDS 402

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1734342184 520 HLHAHKRTHTSEKPYEC--IVCGKSYKQSPSLYTHKKIHTSEKPYECKQCRKSFS 572
Cdd:COG5048   403 NLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
KRAB smart00349
krueppel associated box;
1-31 5.75e-08

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 49.51  E-value: 5.75e-08
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1734342184    1 MLETYSSLLSLNQCDAKPELILKLEKEAEPW 31
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
zf-H2C2_2 pfam13465
Zinc-finger double domain;
492-517 1.28e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.28e-04
                          10        20
                  ....*....|....*....|....*.
gi 1734342184 492 YLTVHQRTHSGEKPYECDVCGKSFKQ 517
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 562-584 5.57e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 5.57e-03
                          10        20
                  ....*....|....*....|...
gi 1734342184 562 YECKQCRKSFSLKFHLTRHQRTH 584
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
376-572 2.12e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 2.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734342184 376 CQQSKLVVSQPAPTQEKRYVCNVCGKAFYKRAHLHAHQRTHTG-EKPYDCQECGKSFRLKSFLVVHQR--IHTGE--KPF 450
Cdd:COG5048   243 QSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPF 322

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734342184 451 ACD--TCGKSFKQRTSLYTHIRIHTGEKPYECKECR-------KSFILKSYLTVHQRTHSGEKPYECDV--CGKSFKQNS 519
Cdd:COG5048   323 SCPysLCGKLFSRNDALKRHILLHTSISPAKEKLLNssskfspLLNNEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDS 402

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1734342184 520 HLHAHKRTHTSEKPYEC--IVCGKSYKQSPSLYTHKKIHTSEKPYECKQCRKSFS 572
Cdd:COG5048   403 NLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
KRAB smart00349
krueppel associated box;
1-31 5.75e-08

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 49.51  E-value: 5.75e-08
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1734342184    1 MLETYSSLLSLNQCDAKPELILKLEKEAEPW 31
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
zf-H2C2_2 pfam13465
Zinc-finger double domain;
492-517 1.28e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.28e-04
                          10        20
                  ....*....|....*....|....*.
gi 1734342184 492 YLTVHQRTHSGEKPYECDVCGKSFKQ 517
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
464-487 2.03e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.03e-04
                          10        20
                  ....*....|....*....|....
gi 1734342184 464 SLYTHIRIHTGEKPYECKECRKSF 487
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
504-570 2.06e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 2.06e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1734342184 504 KPYECDVCGKSFKQNSHLHAHKRTHTSEKPYECIV--CGKSYKQSPSLYTHKKIHTSEKPYECKQCRKS 570
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPL 100
zf-H2C2_2 pfam13465
Zinc-finger double domain;
437-461 3.03e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.03e-04
                          10        20
                  ....*....|....*....|....*
gi 1734342184 437 LVVHQRIHTGEKPFACDTCGKSFKQ 461
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 446-529 6.21e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 6.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734342184 446 GEKPFACDT--CGKSFKQRTSLYTH-IRIHTGEKPYECKECRKsfilksyltvHQRTHSGEKPYECDVCGKSFKQNSHLH 522
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHmLHGHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ....*..
gi 1734342184 523 AHkRTHT 529
Cdd:COG5189   416 YH-RKHS 421
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 506-528 6.89e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 6.89e-04
                          10        20
                  ....*....|....*....|...
gi 1734342184 506 YECDVCGKSFKQNSHLHAHKRTH 528
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 502-554 7.58e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 7.58e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1734342184 502 GEKPYECDV--CGKSFK-QNS----HLHAHKRTHTSE--------------KPYECIVCGKSYKQSPSLYTHKK 554
Cdd:COG5189   346 DGKPYKCPVegCNKKYKnQNGlkyhMLHGHQNQKLHEnpspekmnifsakdKPYRCEVCDKRYKNLNGLKYHRK 419
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
420-480 1.04e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 1.04e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1734342184 420 KPYDCQECGKSFRLKSFLVVHQRIHTGEKPFAC--DTCGKSFKQRTSLYTHIRIHTGEKPYEC 480
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN 94
zf-H2C2_2 pfam13465
Zinc-finger double domain;
524-545 1.96e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.96e-03
                          10        20
                  ....*....|....*....|..
gi 1734342184 524 HKRTHTSEKPYECIVCGKSYKQ 545
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
412-431 2.43e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.43e-03
                          10        20
                  ....*....|....*....|
gi 1734342184 412 HQRTHTGEKPYDCQECGKSF 431
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 562-584 5.57e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 5.57e-03
                          10        20
                  ....*....|....*....|...
gi 1734342184 562 YECKQCRKSFSLKFHLTRHQRTH 584
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 394-416 5.62e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 5.62e-03
                          10        20
                  ....*....|....*....|...
gi 1734342184 394 YVCNVCGKAFYKRAHLHAHQRTH 416
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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