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Conserved domains on  [gi|1728373829|ref|NP_001359117|]
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melanoregulin isoform 1 [Homo sapiens]

Protein Classification

MREG domain-containing protein( domain architecture ID 11239375)

MREG domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MREG pfam15812
Melanoregulin; Melanoregulin is a family of proteins found in eukaryotes. It is a putative ...
46-241 1.97e-79

Melanoregulin; Melanoregulin is a family of proteins found in eukaryotes. It is a putative membrane fusion regulator. MREG forms a complex with peripherin-2. It is required for lysosome maturation and plays a role in intracellular trafficking. It is a negative regulator of melanosome intercellular transfer and it regulates intercellular melanosome transfer through palmitoylation.


:

Pssm-ID: 434956  Cd Length: 148  Bit Score: 236.13  E-value: 1.97e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728373829  46 RDDEKNLWSMPHDVSHTEADDDRTLYNLIVIRNQQAKDSEGvlqsgetsklkhkanhcwelltaplslegarplgtglsw 125
Cdd:pfam15812   3 RDEETNLWSEPHDSSHTERDDDRELYNLIQRRNKLRRGSEG--------------------------------------- 43
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728373829 126 ppppanryskeWQKLNYDIHTLRQVRREVRNRWKCILEDLGFQKEADSLLSVTKLSTISDSKNTRKAREMLLKLAEETNI 205
Cdd:pfam15812  44 -----------WRRLNYDIHALRQVRREVRDRWKKILENLGFQKEADSLLTVTKQTTYSNSRNATKARELLNKLSEETSI 112
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1728373829 206 FPTSWELSERYLFVVDRLIALDAAEEFFKLARRTYP 241
Cdd:pfam15812 113 FPNGSDPPERYLFVLDRLIYLDAADDFLKKARKFYP 148
 
Name Accession Description Interval E-value
MREG pfam15812
Melanoregulin; Melanoregulin is a family of proteins found in eukaryotes. It is a putative ...
46-241 1.97e-79

Melanoregulin; Melanoregulin is a family of proteins found in eukaryotes. It is a putative membrane fusion regulator. MREG forms a complex with peripherin-2. It is required for lysosome maturation and plays a role in intracellular trafficking. It is a negative regulator of melanosome intercellular transfer and it regulates intercellular melanosome transfer through palmitoylation.


Pssm-ID: 434956  Cd Length: 148  Bit Score: 236.13  E-value: 1.97e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728373829  46 RDDEKNLWSMPHDVSHTEADDDRTLYNLIVIRNQQAKDSEGvlqsgetsklkhkanhcwelltaplslegarplgtglsw 125
Cdd:pfam15812   3 RDEETNLWSEPHDSSHTERDDDRELYNLIQRRNKLRRGSEG--------------------------------------- 43
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728373829 126 ppppanryskeWQKLNYDIHTLRQVRREVRNRWKCILEDLGFQKEADSLLSVTKLSTISDSKNTRKAREMLLKLAEETNI 205
Cdd:pfam15812  44 -----------WRRLNYDIHALRQVRREVRDRWKKILENLGFQKEADSLLTVTKQTTYSNSRNATKARELLNKLSEETSI 112
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1728373829 206 FPTSWELSERYLFVVDRLIALDAAEEFFKLARRTYP 241
Cdd:pfam15812 113 FPNGSDPPERYLFVLDRLIYLDAADDFLKKARKFYP 148
 
Name Accession Description Interval E-value
MREG pfam15812
Melanoregulin; Melanoregulin is a family of proteins found in eukaryotes. It is a putative ...
46-241 1.97e-79

Melanoregulin; Melanoregulin is a family of proteins found in eukaryotes. It is a putative membrane fusion regulator. MREG forms a complex with peripherin-2. It is required for lysosome maturation and plays a role in intracellular trafficking. It is a negative regulator of melanosome intercellular transfer and it regulates intercellular melanosome transfer through palmitoylation.


Pssm-ID: 434956  Cd Length: 148  Bit Score: 236.13  E-value: 1.97e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728373829  46 RDDEKNLWSMPHDVSHTEADDDRTLYNLIVIRNQQAKDSEGvlqsgetsklkhkanhcwelltaplslegarplgtglsw 125
Cdd:pfam15812   3 RDEETNLWSEPHDSSHTERDDDRELYNLIQRRNKLRRGSEG--------------------------------------- 43
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728373829 126 ppppanryskeWQKLNYDIHTLRQVRREVRNRWKCILEDLGFQKEADSLLSVTKLSTISDSKNTRKAREMLLKLAEETNI 205
Cdd:pfam15812  44 -----------WRRLNYDIHALRQVRREVRDRWKKILENLGFQKEADSLLTVTKQTTYSNSRNATKARELLNKLSEETSI 112
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1728373829 206 FPTSWELSERYLFVVDRLIALDAAEEFFKLARRTYP 241
Cdd:pfam15812 113 FPNGSDPPERYLFVLDRLIYLDAADDFLKKARKFYP 148
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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