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Conserved domains on  [gi|1700447578|ref|NP_001358250|]
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uncharacterized protein C2orf50 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LLC1 super family cl20827
Normal lung function maintenance, Low in Lung Cancer 1 protein; This protein is part of a ...
 66-130 1.61e-07

Normal lung function maintenance, Low in Lung Cancer 1 protein; This protein is part of a family found in eukaryotes. It is 137 amino acids long in protein sequence length and mass is approximately 15.7 kDa. The protein is present in the normal lung epithelium, but absent or downregulated in most primary non-small lung cancers. The gene is known as Low in Lung Cancer 1 (LLC1). This protein is thought to have a role in the maintenance of normal lung function and its absence may lead to lung tumourigenesis.


The actual alignment was detected with superfamily member pfam14945:

Pssm-ID: 464392  Cd Length: 118  Bit Score: 47.34  E-value: 1.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1700447578  66 VQQDQLWRELLEAERRGQQRWIQNWSFLKD-----YDPMGNKKEPE---KLPDHV---PLF----------SDTVPSSTN 124
Cdd:pfam14945   2 VAQDEIWKDHVKAELEAAKRWPEKWGFLTTpyeelLEDEEEPKKPKpkiELPEHLrirPVTpiekyikvlpSPPVPKTTQ 81


                  ....*.
gi 1700447578 125 QVVGSR 130
Cdd:pfam14945  82 GFIGWR 87
 
Name Accession Description Interval E-value
LLC1 pfam14945
Normal lung function maintenance, Low in Lung Cancer 1 protein; This protein is part of a ...
 66-130 1.61e-07

Normal lung function maintenance, Low in Lung Cancer 1 protein; This protein is part of a family found in eukaryotes. It is 137 amino acids long in protein sequence length and mass is approximately 15.7 kDa. The protein is present in the normal lung epithelium, but absent or downregulated in most primary non-small lung cancers. The gene is known as Low in Lung Cancer 1 (LLC1). This protein is thought to have a role in the maintenance of normal lung function and its absence may lead to lung tumourigenesis.


Pssm-ID: 464392  Cd Length: 118  Bit Score: 47.34  E-value: 1.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1700447578  66 VQQDQLWRELLEAERRGQQRWIQNWSFLKD-----YDPMGNKKEPE---KLPDHV---PLF----------SDTVPSSTN 124
Cdd:pfam14945   2 VAQDEIWKDHVKAELEAAKRWPEKWGFLTTpyeelLEDEEEPKKPKpkiELPEHLrirPVTpiekyikvlpSPPVPKTTQ 81


                  ....*.
gi 1700447578 125 QVVGSR 130
Cdd:pfam14945  82 GFIGWR 87
 
Name Accession Description Interval E-value
LLC1 pfam14945
Normal lung function maintenance, Low in Lung Cancer 1 protein; This protein is part of a ...
 66-130 1.61e-07

Normal lung function maintenance, Low in Lung Cancer 1 protein; This protein is part of a family found in eukaryotes. It is 137 amino acids long in protein sequence length and mass is approximately 15.7 kDa. The protein is present in the normal lung epithelium, but absent or downregulated in most primary non-small lung cancers. The gene is known as Low in Lung Cancer 1 (LLC1). This protein is thought to have a role in the maintenance of normal lung function and its absence may lead to lung tumourigenesis.


Pssm-ID: 464392  Cd Length: 118  Bit Score: 47.34  E-value: 1.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1700447578  66 VQQDQLWRELLEAERRGQQRWIQNWSFLKD-----YDPMGNKKEPE---KLPDHV---PLF----------SDTVPSSTN 124
Cdd:pfam14945   2 VAQDEIWKDHVKAELEAAKRWPEKWGFLTTpyeelLEDEEEPKKPKpkiELPEHLrirPVTpiekyikvlpSPPVPKTTQ 81


                  ....*.
gi 1700447578 125 QVVGSR 130
Cdd:pfam14945  82 GFIGWR 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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