|
Name |
Accession |
Description |
Interval |
E-value |
| DEXXQc_Helz-like |
cd18038 |
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and ... |
498-733 |
2.39e-122 |
|
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and similar proteins. Helicase with zinc finger (HELZ) acts as a helicase that plays a role in RNA metabolism during development. Moloney leukemia virus 10-like protein 1 (Mov10L1) binds Piwi-interacting RNA (piRNA) precursors to initiate piRNA processing. All are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350796 [Multi-domain] Cd Length: 229 Bit Score: 372.34 E-value: 2.39e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 498 ESNPEQLQAMRHIVTGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACAPSNSGADLLCQRLRVHL--PSSI 575
Cdd:cd18038 1 ELNDEQKLAVRNIVTGTSRPPPYIIFGPPGTGKTVTLVEAILQVLRQPPEARILVCAPSNSAADLLAERLLNALvtKREI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 576 YRLLAPSRDIRMVPEDIKPCCNWDAKKGeYVFPAKKKLQEYRVLITTLITAGRLVSAQFPIDHFTHIFIDEAGHCMEPES 655
Cdd:cd18038 81 LRLNAPSRDRASVPPELLPYCNSKAEGT-FRLPSLEELKKYRIVVCTLMTAGRLVQAGVPNGHFTHIFIDEAGQATEPEA 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1610576131 656 LVAIAglmevkETGDPGGQLVLAGDPRQLGPVLRSPLTQKHGLGYSLLERLLTYNSLYKKGpdGYDPQFITKLLRNYR 733
Cdd:cd18038 160 LIPLS------ELASKNTQIVLAGDPKQLGPVVRSPLARKYGLGKSLLERLMERPLYYKDG--EYNPSYITKLLKNYR 229
|
|
| SF1_C_Upf1 |
cd18808 |
C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family ... |
734-939 |
1.52e-66 |
|
C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), and similar proteins. They are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350195 [Multi-domain] Cd Length: 184 Bit Score: 221.34 E-value: 1.52e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 734 SHPTILDIPNQLYYEGELQACADVVDRERFCRWaglPRQGFPIIFHGVMGKDEREGNSPSFFNPEEAATVTSYLKLLLap 813
Cdd:cd18808 1 MHPEISEFPSKLFYEGKLKAGVSVAARLNPPPL---PGPSKPLVFVDVSGGEEREESGTSKSNEAEAELVVELVKYLL-- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 814 sskkgKARLSPRSVGVISPYRKQVEKIRyciTKLDRELRGLDDIKdlkVGSVEEFQGQERSVILISTVRSSQSFVQLdld 893
Cdd:cd18808 76 -----KSGVKPSSIGVITPYRAQVALIR---ELLRKRGGLLEDVE---VGTVDNFQGREKDVIILSLVRSNESGGSI--- 141
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1610576131 894 fnlGFLKNPKRFNVAVTRAKALLIIVGNPLLLGHDPDWKVFLEFCK 939
Cdd:cd18808 142 ---GFLSDPRRLNVALTRAKRGLIIVGNPDTLSKDPLWKKLLEYLE 184
|
|
| AAA_12 |
pfam13087 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
698-922 |
2.89e-61 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.
Pssm-ID: 463780 [Multi-domain] Cd Length: 196 Bit Score: 207.02 E-value: 2.89e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 698 LGYSLLERLLTYNslykkgpdgydPQFITKLLRNYRSHPTILDIPNQLYYEGELQACADVVDRERFCRWAGLPRQGfPII 777
Cdd:pfam13087 1 LDRSLFERLQELG-----------PSAVVMLDTQYRMHPEIMEFPSKLFYGGKLKDGPSVAERPLPDDFHLPDPLG-PLV 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 778 FHGVMGKDEREGNS-PSFFNPEEAATVTSYLKLLLAPSSKKgkarlsPRSVGVISPYRKQVEKIRYcitKLDRELRGLDD 856
Cdd:pfam13087 69 FIDVDGSEEEESDGgTSYSNEAEAELVVQLVEKLIKSGPEE------PSDIGVITPYRAQVRLIRK---LLKRKLGGKLE 139
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1610576131 857 IKdlkVGSVEEFQGQERSVILISTVRSSQsfvqldlDFNLGFLKNPKRFNVAVTRAKALLIIVGNP 922
Cdd:pfam13087 140 IE---VNTVDGFQGREKDVIIFSCVRSNE-------KGGIGFLSDPRRLNVALTRAKRGLIIVGNA 195
|
|
| DNA2 |
COG1112 |
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]; |
613-941 |
3.57e-60 |
|
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair];
Pssm-ID: 440729 [Multi-domain] Cd Length: 819 Bit Score: 221.16 E-value: 3.57e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 613 LQEYRVLITTLITAGRLVSAQFpiDHFTHIFIDEAGHCMEPESLVAIAglmevketgdPGGQLVLAGDPRQLGPVLRSP- 691
Cdd:COG1112 532 LELAPVVGMTPASVARLLPLGE--GSFDLVIIDEASQATLAEALGALA----------RAKRVVLVGDPKQLPPVVFGEe 599
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 692 --LTQKHGLGYSLLERLLtynslykkgpDGYDPQFITkLLRNYRSHPTILDIPNQLYYEGELQACADVVDRErfcrwagL 769
Cdd:COG1112 600 aeEVAEEGLDESLLDRLL----------ARLPERGVM-LREHYRMHPEIIAFSNRLFYDGKLVPLPSPKARR-------L 661
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 770 PRQGFPIIFHGVMGKDEREGNSPSffNPEEAATVTSYLKLLLapsskkgKARLSPRSVGVISPYRKQVEKIRyciTKLDR 849
Cdd:COG1112 662 ADPDSPLVFIDVDGVYERRGGSRT--NPEEAEAVVELVRELL-------EDGPDGESIGVITPYRAQVALIR---ELLRE 729
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 850 ELRGLDDikDLKVGSVEEFQGQERSVILISTVRSSQSfvqlDLDFNLGFL-KNPKRFNVAVTRAKALLIIVGNPLLLGHD 928
Cdd:COG1112 730 ALGDGLE--PVFVGTVDRFQGDERDVIIFSLVYSNDE----DVPRNFGFLnGGPRRLNVAVSRARRKLIVVGSRELLDSD 803
|
330
....*....|....*.
gi 1610576131 929 P---DWKVFLEFCKEN 941
Cdd:COG1112 804 PstpALKRLLEYLERA 819
|
|
| TIGR00376 |
TIGR00376 |
DNA helicase, putative; The gene product may represent a DNA helicase. Eukaryotic members of ... |
485-944 |
1.19e-52 |
|
DNA helicase, putative; The gene product may represent a DNA helicase. Eukaryotic members of this family have been characterized as binding certain single-stranded G-rich DNA sequences (GGGGT and GGGCT). A number of related proteins are characterized as helicases. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273041 [Multi-domain] Cd Length: 636 Bit Score: 195.80 E-value: 1.19e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 485 PSDVKLKLYDRSLesNPEQLQAMRHIVTGTTRpapYIIFGPPGTGKTVTLVEAIKQVVKHLPKahILACAPSNSGADLLC 564
Cdd:TIGR00376 146 SEIHDFQFFDPNL--NESQKEAVLFALSSKDL---FLIHGPPGTGKTRTVVELIRQLVKRGLR--VLVTAPSNIAVDNLL 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 565 QRL--------RVHLPSSIY------------------------------------RLLAPSRDIRMVPEDIKPCCNwDA 600
Cdd:TIGR00376 219 ERLalcdqkivRLGHPARLLksnkqhsldylienhpkyqivadirekidelieernKKTKPSPQKRRGLSDIKILRK-AL 297
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 601 KKGEYVFPAKKKLQEYRVLITTLITAGRLVSAQFPID--------------------------HFTHIFIDEAGHCMEPE 654
Cdd:TIGR00376 298 KKREARGIESLKIASMAEWIETNKSIDRLLKLLPESEerimneilaesdatnsmagseilngqYFDVAVIDEASQAMEPS 377
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 655 SLVAIAGlmevketgdpGGQLVLAGDPRQLGPVLRSplTQKHGLGYSLLERLLtynSLYkkgpdgydPQFITKLLRNYRS 734
Cdd:TIGR00376 378 CLIPLLK----------ARKLILAGDHKQLPPTILS--HDAEELSLTLFERLI---KEY--------PERSRTLNVQYRM 434
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 735 HPTILDIPNQLYYEGELQACADVVDR-----------ERFCRWAglprQGFPIIFHGVMGKD---EREGNSPSFFNPEEA 800
Cdd:TIGR00376 435 NQKIMEFPSREFYNGKLTAHESVANIllrdlpkveatESEDDLE----TGIPLLFIDTSGCElfeLKEADSTSKYNPGEA 510
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 801 ATVTSYLKLLLapsskkgKARLSPRSVGVISPYRKQVEKIRYCItkldrELRGLddikDLKVGSVEEFQGQERSVILIST 880
Cdd:TIGR00376 511 ELVSEIIQALV-------KMGVPANDIGVITPYDAQVDLLRQLL-----EHRHI----DIEVSSVDGFQGREKEVIIISF 574
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1610576131 881 VRSSQSfvqldldFNLGFLKNPKRFNVAVTRAKALLIIVGNPLLLGHDPDWKVFLEFCKENGGY 944
Cdd:TIGR00376 575 VRSNRK-------GEVGFLKDLRRLNVALTRARRKLIVIGDSRTLSNHKFYKRLIEWCKQHGEV 631
|
|
| AAA_11 |
pfam13086 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
503-691 |
2.61e-17 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.
Pssm-ID: 404072 [Multi-domain] Cd Length: 248 Bit Score: 82.78 E-value: 2.61e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 503 QLQAMRHIVTgttRPAPYIIFGPPGTGKTVTLVEAIKQVVKHL-----PKAHILACAPSNSGADLLCQRL---------- 567
Cdd:pfam13086 2 QREAIRSALS---SSHFTLIQGPPGTGKTTTIVELIRQLLSYPatsaaAGPRILVCAPSNAAVDNILERLlrkgqkygpk 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 568 --RVHLPSSI-------------------YRLLAPSRDIR--------MVPEDIKPCCNWDAKKGEYVFPAK-------- 610
Cdd:pfam13086 79 ivRIGHPAAIseavlpvsldylvesklnnEEDAQIVKDISkeleklakALRAFEKEIIVEKLLKSRNKDKSKleqerrkl 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 611 ----KKLQEY----------------RVLITTLITAGRLV---SAQFPIdhfthIFIDEAGHCMEPESLVAIagLMEVKe 667
Cdd:pfam13086 159 rserKELRKElrrreqslereildeaQIVCSTLSGAGSRLlssLANFDV-----VIIDEAAQALEPSTLIPL--LRGPK- 230
|
250 260
....*....|....*....|....
gi 1610576131 668 tgdpggQLVLAGDPRQLGPVLRSP 691
Cdd:pfam13086 231 ------KVVLVGDPKQLPPTVISK 248
|
|
| RecD |
COG0507 |
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) ... |
496-687 |
5.39e-11 |
|
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];
Pssm-ID: 440273 [Multi-domain] Cd Length: 514 Bit Score: 66.15 E-value: 5.39e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 496 SLESNPEQLQAMRHIVTgtTRPApYIIFGPPGTGKTvTLVEAIKQVVKHLpKAHILACAPSNSGAdllcQRLR--VHLPS 573
Cdd:COG0507 122 GITLSDEQREAVALALT--TRRV-SVLTGGAGTGKT-TTLRALLAALEAL-GLRVALAAPTGKAA----KRLSesTGIEA 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 574 S-IYRLLApsrdirmvpedikpccnWDAKKGEYVFPAKKKLQEYRVLIttlitagrlvsaqfpidhfthifIDEAghcme 652
Cdd:COG0507 193 RtIHRLLG-----------------LRPDSGRFRHNRDNPLTPADLLV-----------------------VDEA----- 227
|
170 180 190
....*....|....*....|....*....|....*..
gi 1610576131 653 peSLVAIAgLME--VKETGDPGGQLVLAGDPRQLGPV 687
Cdd:COG0507 228 --SMVDTR-LMAalLEALPRAGARLILVGDPDQLPSV 261
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
500-655 |
2.76e-06 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 49.03 E-value: 2.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 500 NPEQLQAMRHIVTGTTRpapYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACAPSNSGADLLCQRLRVHLPSSiyrll 579
Cdd:smart00487 10 RPYQKEAIEALLSGLRD---VILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPTRELAEQWAEELKKLGPSL----- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 580 apsrdirmvpeDIKPCCNWDAKKGEYVFpAKKKLQEYRVLITTLitaGRLVSA----QFPIDHFTHIFIDEAgHCMEPES 655
Cdd:smart00487 82 -----------GLKVVGLYGGDSKREQL-RKLESGKTDILVTTP---GRLLDLlendKLSLSNVDLVILDEA-HRLLDGG 145
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| DEXXQc_Helz-like |
cd18038 |
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and ... |
498-733 |
2.39e-122 |
|
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and similar proteins. Helicase with zinc finger (HELZ) acts as a helicase that plays a role in RNA metabolism during development. Moloney leukemia virus 10-like protein 1 (Mov10L1) binds Piwi-interacting RNA (piRNA) precursors to initiate piRNA processing. All are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350796 [Multi-domain] Cd Length: 229 Bit Score: 372.34 E-value: 2.39e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 498 ESNPEQLQAMRHIVTGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACAPSNSGADLLCQRLRVHL--PSSI 575
Cdd:cd18038 1 ELNDEQKLAVRNIVTGTSRPPPYIIFGPPGTGKTVTLVEAILQVLRQPPEARILVCAPSNSAADLLAERLLNALvtKREI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 576 YRLLAPSRDIRMVPEDIKPCCNWDAKKGeYVFPAKKKLQEYRVLITTLITAGRLVSAQFPIDHFTHIFIDEAGHCMEPES 655
Cdd:cd18038 81 LRLNAPSRDRASVPPELLPYCNSKAEGT-FRLPSLEELKKYRIVVCTLMTAGRLVQAGVPNGHFTHIFIDEAGQATEPEA 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1610576131 656 LVAIAglmevkETGDPGGQLVLAGDPRQLGPVLRSPLTQKHGLGYSLLERLLTYNSLYKKGpdGYDPQFITKLLRNYR 733
Cdd:cd18038 160 LIPLS------ELASKNTQIVLAGDPKQLGPVVRSPLARKYGLGKSLLERLMERPLYYKDG--EYNPSYITKLLKNYR 229
|
|
| DEXXQc_Mov10L1 |
cd18078 |
DEXXQ-box helicase domain of Mov10L1; Moloney leukemia virus 10-like protein 1 (Mov10L1) binds ... |
500-733 |
2.57e-77 |
|
DEXXQ-box helicase domain of Mov10L1; Moloney leukemia virus 10-like protein 1 (Mov10L1) binds Piwi-interacting RNA (piRNA) precursors to initiate piRNA processing. Mov10L1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350836 [Multi-domain] Cd Length: 230 Bit Score: 252.67 E-value: 2.57e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 500 NPEQLQAMRHIVTGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACAPSNSGADLLCQRL---RVHLPSSIY 576
Cdd:cd18078 3 NELQKEAVKRILGGECRPLPYILFGPPGTGKTVTIIEAILQVVYNLPRSRILVCAPSNSAADLVTSRLhesKVLKPGDMV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 577 RLLAPSRDIRMVPEDIKPCCnwdaKKGEyvfpAKKKLQEYRVLITTLITAGRLVSAQFPIDHFTHIFIDEAGHCMEPESL 656
Cdd:cd18078 83 RLNAVNRFESTVIDARKLYC----RLGE----DLSKASRHRIVISTCSTAGLLYQMGLPVGHFTHVFVDEAGQATEPESL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 657 VAIaGLMEvketgDPGGQLVLAGDPRQLGPVLRSPLTQKHGLGYSLLERLLTYNsLYKKGPD------GYDPQFITKLLR 730
Cdd:cd18078 155 IPL-GLIS-----SRDGQIILAGDPMQLGPVIKSRLASAYGLGVSFLERLMNRP-LYLRDPNrfgesgGYNPLLVTKLVD 227
|
...
gi 1610576131 731 NYR 733
Cdd:cd18078 228 NYR 230
|
|
| SF1_C_Upf1 |
cd18808 |
C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family ... |
734-939 |
1.52e-66 |
|
C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), and similar proteins. They are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350195 [Multi-domain] Cd Length: 184 Bit Score: 221.34 E-value: 1.52e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 734 SHPTILDIPNQLYYEGELQACADVVDRERFCRWaglPRQGFPIIFHGVMGKDEREGNSPSFFNPEEAATVTSYLKLLLap 813
Cdd:cd18808 1 MHPEISEFPSKLFYEGKLKAGVSVAARLNPPPL---PGPSKPLVFVDVSGGEEREESGTSKSNEAEAELVVELVKYLL-- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 814 sskkgKARLSPRSVGVISPYRKQVEKIRyciTKLDRELRGLDDIKdlkVGSVEEFQGQERSVILISTVRSSQSFVQLdld 893
Cdd:cd18808 76 -----KSGVKPSSIGVITPYRAQVALIR---ELLRKRGGLLEDVE---VGTVDNFQGREKDVIILSLVRSNESGGSI--- 141
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1610576131 894 fnlGFLKNPKRFNVAVTRAKALLIIVGNPLLLGHDPDWKVFLEFCK 939
Cdd:cd18808 142 ---GFLSDPRRLNVALTRAKRGLIIVGNPDTLSKDPLWKKLLEYLE 184
|
|
| AAA_12 |
pfam13087 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
698-922 |
2.89e-61 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.
Pssm-ID: 463780 [Multi-domain] Cd Length: 196 Bit Score: 207.02 E-value: 2.89e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 698 LGYSLLERLLTYNslykkgpdgydPQFITKLLRNYRSHPTILDIPNQLYYEGELQACADVVDRERFCRWAGLPRQGfPII 777
Cdd:pfam13087 1 LDRSLFERLQELG-----------PSAVVMLDTQYRMHPEIMEFPSKLFYGGKLKDGPSVAERPLPDDFHLPDPLG-PLV 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 778 FHGVMGKDEREGNS-PSFFNPEEAATVTSYLKLLLAPSSKKgkarlsPRSVGVISPYRKQVEKIRYcitKLDRELRGLDD 856
Cdd:pfam13087 69 FIDVDGSEEEESDGgTSYSNEAEAELVVQLVEKLIKSGPEE------PSDIGVITPYRAQVRLIRK---LLKRKLGGKLE 139
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1610576131 857 IKdlkVGSVEEFQGQERSVILISTVRSSQsfvqldlDFNLGFLKNPKRFNVAVTRAKALLIIVGNP 922
Cdd:pfam13087 140 IE---VNTVDGFQGREKDVIIFSCVRSNE-------KGGIGFLSDPRRLNVALTRAKRGLIIVGNA 195
|
|
| DNA2 |
COG1112 |
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]; |
613-941 |
3.57e-60 |
|
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair];
Pssm-ID: 440729 [Multi-domain] Cd Length: 819 Bit Score: 221.16 E-value: 3.57e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 613 LQEYRVLITTLITAGRLVSAQFpiDHFTHIFIDEAGHCMEPESLVAIAglmevketgdPGGQLVLAGDPRQLGPVLRSP- 691
Cdd:COG1112 532 LELAPVVGMTPASVARLLPLGE--GSFDLVIIDEASQATLAEALGALA----------RAKRVVLVGDPKQLPPVVFGEe 599
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 692 --LTQKHGLGYSLLERLLtynslykkgpDGYDPQFITkLLRNYRSHPTILDIPNQLYYEGELQACADVVDRErfcrwagL 769
Cdd:COG1112 600 aeEVAEEGLDESLLDRLL----------ARLPERGVM-LREHYRMHPEIIAFSNRLFYDGKLVPLPSPKARR-------L 661
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 770 PRQGFPIIFHGVMGKDEREGNSPSffNPEEAATVTSYLKLLLapsskkgKARLSPRSVGVISPYRKQVEKIRyciTKLDR 849
Cdd:COG1112 662 ADPDSPLVFIDVDGVYERRGGSRT--NPEEAEAVVELVRELL-------EDGPDGESIGVITPYRAQVALIR---ELLRE 729
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 850 ELRGLDDikDLKVGSVEEFQGQERSVILISTVRSSQSfvqlDLDFNLGFL-KNPKRFNVAVTRAKALLIIVGNPLLLGHD 928
Cdd:COG1112 730 ALGDGLE--PVFVGTVDRFQGDERDVIIFSLVYSNDE----DVPRNFGFLnGGPRRLNVAVSRARRKLIVVGSRELLDSD 803
|
330
....*....|....*.
gi 1610576131 929 P---DWKVFLEFCKEN 941
Cdd:COG1112 804 PstpALKRLLEYLERA 819
|
|
| TIGR00376 |
TIGR00376 |
DNA helicase, putative; The gene product may represent a DNA helicase. Eukaryotic members of ... |
485-944 |
1.19e-52 |
|
DNA helicase, putative; The gene product may represent a DNA helicase. Eukaryotic members of this family have been characterized as binding certain single-stranded G-rich DNA sequences (GGGGT and GGGCT). A number of related proteins are characterized as helicases. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273041 [Multi-domain] Cd Length: 636 Bit Score: 195.80 E-value: 1.19e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 485 PSDVKLKLYDRSLesNPEQLQAMRHIVTGTTRpapYIIFGPPGTGKTVTLVEAIKQVVKHLPKahILACAPSNSGADLLC 564
Cdd:TIGR00376 146 SEIHDFQFFDPNL--NESQKEAVLFALSSKDL---FLIHGPPGTGKTRTVVELIRQLVKRGLR--VLVTAPSNIAVDNLL 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 565 QRL--------RVHLPSSIY------------------------------------RLLAPSRDIRMVPEDIKPCCNwDA 600
Cdd:TIGR00376 219 ERLalcdqkivRLGHPARLLksnkqhsldylienhpkyqivadirekidelieernKKTKPSPQKRRGLSDIKILRK-AL 297
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 601 KKGEYVFPAKKKLQEYRVLITTLITAGRLVSAQFPID--------------------------HFTHIFIDEAGHCMEPE 654
Cdd:TIGR00376 298 KKREARGIESLKIASMAEWIETNKSIDRLLKLLPESEerimneilaesdatnsmagseilngqYFDVAVIDEASQAMEPS 377
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 655 SLVAIAGlmevketgdpGGQLVLAGDPRQLGPVLRSplTQKHGLGYSLLERLLtynSLYkkgpdgydPQFITKLLRNYRS 734
Cdd:TIGR00376 378 CLIPLLK----------ARKLILAGDHKQLPPTILS--HDAEELSLTLFERLI---KEY--------PERSRTLNVQYRM 434
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 735 HPTILDIPNQLYYEGELQACADVVDR-----------ERFCRWAglprQGFPIIFHGVMGKD---EREGNSPSFFNPEEA 800
Cdd:TIGR00376 435 NQKIMEFPSREFYNGKLTAHESVANIllrdlpkveatESEDDLE----TGIPLLFIDTSGCElfeLKEADSTSKYNPGEA 510
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 801 ATVTSYLKLLLapsskkgKARLSPRSVGVISPYRKQVEKIRYCItkldrELRGLddikDLKVGSVEEFQGQERSVILIST 880
Cdd:TIGR00376 511 ELVSEIIQALV-------KMGVPANDIGVITPYDAQVDLLRQLL-----EHRHI----DIEVSSVDGFQGREKEVIIISF 574
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1610576131 881 VRSSQSfvqldldFNLGFLKNPKRFNVAVTRAKALLIIVGNPLLLGHDPDWKVFLEFCKENGGY 944
Cdd:TIGR00376 575 VRSNRK-------GEVGFLKDLRRLNVALTRARRKLIVIGDSRTLSNHKFYKRLIEWCKQHGEV 631
|
|
| DEXXQc_HELZ |
cd18077 |
DEXXQ-box helicase domain of HELZ; Helicase with zinc finger (HELZ) acts as a helicase that ... |
500-733 |
6.64e-31 |
|
DEXXQ-box helicase domain of HELZ; Helicase with zinc finger (HELZ) acts as a helicase that plays a role in RNA metabolism during development. HELZ is a member of the family I class of RNA helicases of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350835 [Multi-domain] Cd Length: 226 Bit Score: 121.44 E-value: 6.64e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 500 NPEQLQAMRHIVTGTTRPAPYI-IFGPPGTGKTVTLVEAIKQVVKHlPKAHILACAPSNSGADLLCQR------LRVHLP 572
Cdd:cd18077 3 NAKQKEAVLAITTPLSIQLPPVlLIGPFGTGKTFTLAQAVKHILQQ-PETRILICTHSNSAADLYIKEylhpyvETGNPR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 573 SSIYRLLAPSRDIRMVPEDIKPCCNWDAKkGEYVFPAKKKLQEYRVLITTLITAGRLVSAQFPIDHFTHIFIDEAGHCME 652
Cdd:cd18077 82 ARPLRVYYRNRWVKTVHPVVQKYCLIDEH-GTFRMPTREDVMRHRVVVVTLSTSQYLCQLDLEPGFFTHILLDEAAQAME 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 653 PESLVAIAglMEVKETgdpggQLVLAGDPRQLGPVLRSPLTQKHGLGYSLLERLLTYnslykkgpdgYDPQF--ITKLLR 730
Cdd:cd18077 161 CEAIMPLA--LATKST-----RIVLAGDHMQLSPEVYSEFARERNLHISLLERLYEH----------YPSEHpcRILLCE 223
|
...
gi 1610576131 731 NYR 733
Cdd:cd18077 224 NYR 226
|
|
| DEXXQc_SMUBP2 |
cd18044 |
DEXXQ-box helicase domain of SMUBP2; SMUBP2 (also called immunoglobulin mu-binding protein 2, ... |
521-707 |
5.31e-30 |
|
DEXXQ-box helicase domain of SMUBP2; SMUBP2 (also called immunoglobulin mu-binding protein 2, or IGHMBP2) is a 5' to 3' helicase that unwinds RNA and DNA duplexes in an ATP-dependent reaction. It is a DNA-binding protein specific to 5'-phosphorylated single-stranded guanine-rich sequence (5'-GGGCT-3') related to the immunoglobulin mu chain switch region. The IGHMBP2 gene is responsible for Charcot-Marie-Tooth disease (CMT) type 2S and spinal muscular atrophy with respiratory distress type 1 (SMARD1). It is also thought to play a role in frontotemporal dementia (FTD) with amyotrophic lateral sclerosis (ALS) and major depressive disorder (MDD). SMUBP2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350802 [Multi-domain] Cd Length: 191 Bit Score: 117.71 E-value: 5.31e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 521 IIFGPPGTGKTVTLVEAIKQVVKhlPKAHILACAPSNSGADLLCQRLrVHLPSSIYRLLAPSRdirmVPEDIKPCCnWDA 600
Cdd:cd18044 21 LIHGPPGTGKTTTVVEIILQAVK--RGEKVLACAPSNIAVDNLVERL-VALKVKVVRIGHPAR----LLESVLDHS-LDA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 601 kkgeyvfpakkkLQEYRVLITTLITAGrlvSAQF-PIDHFTHIFIDEAGHCMEPESLVAIAglmevketgdPGGQLVLAG 679
Cdd:cd18044 93 ------------LVAAQVVLATNTGAG---SRQLlPNELFDVVVIDEAAQALEASCWIPLL----------KARRCILAG 147
|
170 180
....*....|....*....|....*...
gi 1610576131 680 DPRQLGPVLRSPLTQKHGLGYSLLERLL 707
Cdd:cd18044 148 DHKQLPPTILSDKAARGGLGVTLFERLV 175
|
|
| DEXXQc_UPF1 |
cd18039 |
DEXXQ-box helicase domain of UPF1; UPF1 (also called RNA Helicase And ATPase, Regulator Of ... |
500-707 |
1.70e-29 |
|
DEXXQ-box helicase domain of UPF1; UPF1 (also called RNA Helicase And ATPase, Regulator Of Nonsense Transcripts, or ATP-Dependent Helicase RENT1) is an RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. It is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. It is recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) located downstream from the termination codon through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Diseases associated with UPF1 include juvenile amyotrophic lateral sclerosis and epidermolysis bullosa, junctional, non-Herlitz type. UPF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350797 [Multi-domain] Cd Length: 234 Bit Score: 117.73 E-value: 1.70e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 500 NPEQLQAMRHIVTgttRPAPYIIfGPPGTGKTVTlveaIKQVVKHLPKAH---ILACAPSNSGADLLCQRL--------- 567
Cdd:cd18039 3 NHSQVDAVKTALQ---RPLSLIQ-GPPGTGKTVT----SATIVYHLVKQGngpVLVCAPSNVAVDQLTEKIhqtglkvvr 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 568 -----RVHLPSSIYrLLAPSRDIR------------MVPEDIKPCCNWDAKKGEYVFPAKKK--LQEYRVLITTLITAG- 627
Cdd:cd18039 75 lcaksREAVESPVS-FLALHNQVRnldsaeklellkLLKLETGELSSADEKRYRKLKRKAERelLRNADVICCTCVGAGd 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 628 -RLVSAQFPidhftHIFIDEAGHCMEPESLVAIagLMEVKetgdpggQLVLAGDPRQLGPVLRSPLTQKHGLGYSLLERL 706
Cdd:cd18039 154 pRLSKMKFR-----TVLIDEATQATEPECLIPL--VHGAK-------QVILVGDHCQLGPVVMCKKAAKAGLSQSLFERL 219
|
.
gi 1610576131 707 L 707
Cdd:cd18039 220 V 220
|
|
| DEXXQc_HELZ2-N |
cd18076 |
N-terminal DEXXQ-box helicase domain of HELZ2; Helicase with zinc finger 2 (HELZ2, also known ... |
500-709 |
1.83e-24 |
|
N-terminal DEXXQ-box helicase domain of HELZ2; Helicase with zinc finger 2 (HELZ2, also known as PPAR-alpha-interacting complex protein 285 or PRIC285 and PPAR-gamma DBD-interacting protein 1 or PDIP1) acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB, and RXRA. It belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350834 [Multi-domain] Cd Length: 230 Bit Score: 103.05 E-value: 1.83e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 500 NPEQLQAMRHIV---TGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHlPKAHILACAPSNSGADLLcqrLRVHLPSSI- 575
Cdd:cd18076 3 NNKQQLAFNFIAgkpSEARFVPPLLIYGPFGTGKTFTLAMAALEVIRE-PGTKVLICTHTNSAADIY---IREYFHPYVd 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 576 --------YRLLAPSRDIRMV-PEDIKPCCNWDAKKGeYVFPAKKKLQEYRVLITTLITAGRLVSaqfPIDHFTHIFIDE 646
Cdd:cd18076 79 kghpearpLRIKATDRPNAITdPDTITYCCLTKDRQC-FRLPTRDELDFHNIVITTTAMAFNLHV---LSGFFTHIFIDE 154
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1610576131 647 AGHCMEPESLVAIAglmevkeTGDPGGQLVLAGDPRQLGPVLRSpLTQKHGLGYSLLERLLTY 709
Cdd:cd18076 155 AAQMLECEALIPLS-------YAGPKTRVVLAGDHMQMTPKLFS-VADYNRANHTLLNRLFHY 209
|
|
| DEXXQc_SETX |
cd18042 |
DEXXQ-box helicase domain of SETX; The RNA/DNA helicase senataxin (SETX) plays a role in ... |
500-706 |
3.50e-19 |
|
DEXXQ-box helicase domain of SETX; The RNA/DNA helicase senataxin (SETX) plays a role in transcription, neurogenesis, and antiviral response. SEXT is an R-loop-associated protein that is thought to function as an RNA/DNA helicase. R-loops consist of RNA/DNA hybrids, formed during transcription when nascent RNA hybridizes to the DNA template strand, displacing the non-template DNA strand. Mutations in SETX are linked to two neurodegenerative disorders: ataxia with oculomotor apraxia type 2 (AOA2) and amyotrophic lateral sclerosis type 4 (ALS4). S. cerevisiae homolog splicing endonuclease 1 (Sen1) is an exclusively nuclear protein, important for nucleolar organization. S. cerevisiae Sen1 and its ortholog, the Schizosaccharomyces pombe Sen1, share conserved domains and belong to the family I class of helicases. Both proteins translocate 5' to 3' and unwind both DNA and RNA duplexes and also RNA/DNA hybrids in vitro. SETX is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438712 [Multi-domain] Cd Length: 218 Bit Score: 87.27 E-value: 3.50e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 500 NPEQLQAMRHIVTGTTRPApyIIFGPPGTGKTVTLVEAI-----------------------KQVVKHLPKAHILACAPS 556
Cdd:cd18042 2 NESQLEAIASALQNSPGIT--LIQGPPGTGKTKTIVGILsvllagkyrkyyekvkkklrklqRNLNNKKKKNRILVCAPS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 557 NSGADLLCQRLRVHLPSSIYRLLAPSRDIRMVPEDIKpccnwdakkgeyvfpaKKKLQEYRVLITTLITAGRLVSAQFPi 636
Cdd:cd18042 80 NAAVDEIVLRLLSEGFLDGDGRSYKPNVVRVGRQELR----------------ASILNEADIVCTTLSSSGSDLLESLP- 142
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 637 DHFTHIFIDEAGHCMEPESLVAIAGLMEvketgdpggQLVLAGDPRQLGPVLRSPLTQKHGLGYSLLERL 706
Cdd:cd18042 143 RGFDTVIIDEAAQAVELSTLIPLRLGCK---------RLILVGDPKQLPATVFSKVAQKLGYDRSLFERL 203
|
|
| AAA_11 |
pfam13086 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
503-691 |
2.61e-17 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.
Pssm-ID: 404072 [Multi-domain] Cd Length: 248 Bit Score: 82.78 E-value: 2.61e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 503 QLQAMRHIVTgttRPAPYIIFGPPGTGKTVTLVEAIKQVVKHL-----PKAHILACAPSNSGADLLCQRL---------- 567
Cdd:pfam13086 2 QREAIRSALS---SSHFTLIQGPPGTGKTTTIVELIRQLLSYPatsaaAGPRILVCAPSNAAVDNILERLlrkgqkygpk 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 568 --RVHLPSSI-------------------YRLLAPSRDIR--------MVPEDIKPCCNWDAKKGEYVFPAK-------- 610
Cdd:pfam13086 79 ivRIGHPAAIseavlpvsldylvesklnnEEDAQIVKDISkeleklakALRAFEKEIIVEKLLKSRNKDKSKleqerrkl 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 611 ----KKLQEY----------------RVLITTLITAGRLV---SAQFPIdhfthIFIDEAGHCMEPESLVAIagLMEVKe 667
Cdd:pfam13086 159 rserKELRKElrrreqslereildeaQIVCSTLSGAGSRLlssLANFDV-----VIIDEAAQALEPSTLIPL--LRGPK- 230
|
250 260
....*....|....*....|....
gi 1610576131 668 tgdpggQLVLAGDPRQLGPVLRSP 691
Cdd:pfam13086 231 ------KVVLVGDPKQLPPTVISK 248
|
|
| DEXXc_HELZ2-C |
cd18040 |
C-terminal DEXX-box helicase domain of HELZ2; Helicase with zinc finger 2 (HELZ2, also known ... |
500-706 |
2.91e-16 |
|
C-terminal DEXX-box helicase domain of HELZ2; Helicase with zinc finger 2 (HELZ2, also known as PPAR-alpha-interacting complex protein 285 or PRIC285 and PPAR-gamma DBD-interacting protein 1 or PDIP1) acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA. It belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350798 [Multi-domain] Cd Length: 271 Bit Score: 80.26 E-value: 2.91e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 500 NPEQLQAMRhivTGTTRPApYIIFGPPGTGKTVTLV-----------EAIKQVVKHLPKAHILACAPSNSGAD----LLC 564
Cdd:cd18040 3 NPSQNHAVR---TALTKPF-TLIQGPPGTGKTVTGVhiaywfakqnrEIQSVSGEGDGGPCVLYCGPSNKSVDvvaeLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 565 QR-----LRVH----------LPSSIYRLLAPSRD----------------IRMVP----EDIKPCCNWDAKKGEYVfpA 609
Cdd:cd18040 79 KVpglkiLRVYseqietteypIPNEPRHPNKKSEReskpnselssitlhhrIRQPSnphsQQIKAFEARFERTQEKI--T 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 610 KKKLQEYRVLITT------------LITAGRLVSAQF-PIDHFTHIFIDEAGHCMEPESLVAIAGLMEVKetgdpggQLV 676
Cdd:cd18040 157 EEDIKTYKILIWEarfeeletvdviLCTCSEAASQKMrTHANVKQCIVDECGMCTEPESLIPIVSAPRAE-------QVV 229
|
250 260 270
....*....|....*....|....*....|
gi 1610576131 677 LAGDPRQLGPVLRSPLTQKHGLGYSLLERL 706
Cdd:cd18040 230 LIGDHKQLRPVVQNKEAQKLGLGRSLFERY 259
|
|
| DEXXQc_Upf1-like |
cd17934 |
DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, ... |
521-733 |
5.40e-15 |
|
DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), coronavirus Nsp13, and similar proteins. They belong to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438708 [Multi-domain] Cd Length: 121 Bit Score: 72.27 E-value: 5.40e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 521 IIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACAPSNSgadllcqrlrvhlpssiyrllapsrdirmvpedikpccnwda 600
Cdd:cd17934 3 LIQGPPGTGKTTTIAAIVLQLLKGLRGKRVLVTAQSNV------------------------------------------ 40
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 601 kkgeyvfpakkklqeyrvlittlitagrlvsaqfPIDHFTHIFIDEAGHCMEPESLVAIAGlmevketgdpGGQLVLAGD 680
Cdd:cd17934 41 ----------------------------------AVDNVDVVIIDEASQITEPELLIALIR----------AKKVVLVGD 76
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1610576131 681 PRQLGPVLRSPLTQKHGLGYSLLERLLTYNSLYkkgpdGYDPQFitkLLRNYR 733
Cdd:cd17934 77 PKQLPPVVQEDHAALLGLSFILSLLLLFRLLLP-----GSPKVM---LDTQYR 121
|
|
| DEXXQc_DNA2 |
cd18041 |
DEXXQ-box helicase domain of DNA2; DNA2 (DNA Replication Helicase/Nuclease 2) possesses ... |
500-733 |
6.59e-14 |
|
DEXXQ-box helicase domain of DNA2; DNA2 (DNA Replication Helicase/Nuclease 2) possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5-3 helicase, and endonuclease activities, and is involved in DNA replication and DNA repair in the nucleus and mitochondrion. It is involved in Okazaki fragment processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. It is also involved in 5-end resection of DNA during double-strand break (DSB) repair; it is recruited by BLM and mediates the cleavage of 5-ssDNA, while the 3-ssDNA cleavage is prevented by the presence of RPA. DNA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350799 [Multi-domain] Cd Length: 203 Bit Score: 71.50 E-value: 6.59e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 500 NPEQLQAMRHIVTGTTrpapY-IIFGPPGTGKTVTLVEAIKqvVKHLPKAHILACAPSNSGADLLCQRLRVHlPSSIYRL 578
Cdd:cd18041 3 NKDQRQAIKKVLNAKD----YaLILGMPGTGKTTTIAALVR--ILVALGKSVLLTSYTHSAVDNILLKLKKF-GVNFLRL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 579 lapSRDIRMVPEDIKPCCNWDAKKGEYVFPAKKKLQEYRVLITTLITagrlvsaqfpIDHftHIF---------IDEAGH 649
Cdd:cd18041 76 ---GRLKKIHPDVQEFTLEAILKSCKSVEELESKYESVSVVATTCLG----------INH--PIFrrrtfdyciVDEASQ 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 650 CMEPESLVAIAGlmevketgdpGGQLVLAGDPRQLGPVLRSPLTQKHGLGYSLLERLLtynslyKKGPDGydpqfITKLL 729
Cdd:cd18041 141 ITLPICLGPLRL----------AKKFVLVGDHYQLPPLVKSREARELGMDESLFKRLS------EAHPDA-----VVQLT 199
|
....
gi 1610576131 730 RNYR 733
Cdd:cd18041 200 IQYR 203
|
|
| RecD |
COG0507 |
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) ... |
496-687 |
5.39e-11 |
|
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];
Pssm-ID: 440273 [Multi-domain] Cd Length: 514 Bit Score: 66.15 E-value: 5.39e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 496 SLESNPEQLQAMRHIVTgtTRPApYIIFGPPGTGKTvTLVEAIKQVVKHLpKAHILACAPSNSGAdllcQRLR--VHLPS 573
Cdd:COG0507 122 GITLSDEQREAVALALT--TRRV-SVLTGGAGTGKT-TTLRALLAALEAL-GLRVALAAPTGKAA----KRLSesTGIEA 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 574 S-IYRLLApsrdirmvpedikpccnWDAKKGEYVFPAKKKLQEYRVLIttlitagrlvsaqfpidhfthifIDEAghcme 652
Cdd:COG0507 193 RtIHRLLG-----------------LRPDSGRFRHNRDNPLTPADLLV-----------------------VDEA----- 227
|
170 180 190
....*....|....*....|....*....|....*..
gi 1610576131 653 peSLVAIAgLME--VKETGDPGGQLVLAGDPRQLGPV 687
Cdd:COG0507 228 --SMVDTR-LMAalLEALPRAGARLILVGDPDQLPSV 261
|
|
| AAA_30 |
pfam13604 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
500-687 |
4.46e-10 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. There is a Walker A and Walker B.
Pssm-ID: 433343 [Multi-domain] Cd Length: 191 Bit Score: 60.27 E-value: 4.46e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 500 NPEQLQAMRHIVTGTTRPApyIIFGPPGTGKTvTLVEAIKQVVKHLPKaHILACAPSNSGADLLCQRLRVHlPSSIYRLL 579
Cdd:pfam13604 3 NAEQAAAVRALLTSGDRVA--VLVGPAGTGKT-TALKALREAWEAAGY-RVIGLAPTGRAAKVLGEELGIP-ADTIAKLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 580 APSRDirmvpedikpccnwdakkgeyvfpakkklqeyrvliTTLITAGRLVsaqfpidhfthiFIDEAGhcmepesLVAI 659
Cdd:pfam13604 78 HRLGG------------------------------------RAGLDPGTLL------------IVDEAG-------MVGT 102
|
170 180
....*....|....*....|....*....
gi 1610576131 660 AGLMEV-KETGDPGGQLVLAGDPRQLGPV 687
Cdd:pfam13604 103 RQMARLlKLAEDAGARVILVGDPRQLPSV 131
|
|
| DEXSc_RecD-like |
cd17933 |
DEXS-box helicase domain of RecD and similar proteins; RecD is a member of the RecBCD (EC 3.1. ... |
502-687 |
4.87e-09 |
|
DEXS-box helicase domain of RecD and similar proteins; RecD is a member of the RecBCD (EC 3.1.11.5, Exonuclease V) complex. It is the alpha chain of the complex and functions as a 3'-5' helicase. The RecBCD enzyme is both a helicase that unwinds, or separates the strands of DNA, and a nuclease that makes single-stranded nicks in DNA. RecD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350691 [Multi-domain] Cd Length: 155 Bit Score: 56.02 E-value: 4.87e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 502 EQLQAMRHIVTGttrpaPYIIF-GPPGTGKTVTLveaiKQVVKHL--PKAHILACAPSNSGAdllcQRLR--VHLPSS-I 575
Cdd:cd17933 1 EQKAAVRLVLRN-----RVSVLtGGAGTGKTTTL----KALLAALeaEGKRVVLAAPTGKAA----KRLSesTGIEAStI 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 576 YRLLapsrdirmvpedikpccnWDAKKGEYVFPAKKKLQEYRVLIttlitagrlvsaqfpidhfthifIDEAghcmepeS 655
Cdd:cd17933 68 HRLL------------------GINPGGGGFYYNEENPLDADLLI-----------------------VDEA-------S 99
|
170 180 190
....*....|....*....|....*....|...
gi 1610576131 656 LVAIAgLME-VKETGDPGGQLVLAGDPRQLGPV 687
Cdd:cd17933 100 MVDTR-LMAaLLSAIPAGARLILVGDPDQLPSV 131
|
|
| EEXXEc_NFX1 |
cd17936 |
EEXXE-box helicase domain of NFX1; Human NFX1 protein was identified as a protein that ... |
500-706 |
7.77e-08 |
|
EEXXE-box helicase domain of NFX1; Human NFX1 protein was identified as a protein that represses class II MHC (major histocompatibility complex) gene expression. NFX1 binds a conserved cis-acting element, termed the X-box, in promoters of human class II MHC genes. The Cys-rich region contains several NFX1-type zinc finger domains. Frequently, a R3H domain is present in the C-terminus, and a RING finger domain and a PAM2 motif are present in the N-terminus. The lack of R3H and PAM2 motifs in the plant proteins indicates functional differences. Plant NFX1-like proteins are proposed to modulate growth and survival by coordinating reactive oxygen species, salicylic acid, further biotic stress and abscisic acid responses. A common feature of all members may be E3 ubiquitin ligase, due to the presence of a RING finger domain, as well as DNA binding. NFX1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350694 [Multi-domain] Cd Length: 178 Bit Score: 53.32 E-value: 7.77e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 500 NPEQLQAMRHIVTgtTRPApyIIFGPPGTGKT---VTLVEAIKQVVKHLPKAHILACAPSNSGADLLCQRLRVHLPSSIY 576
Cdd:cd17936 3 DPSQLEALKHALT--SELA--LIQGPPGTGKTflgVKLVRALLQNQDLSITGPILVVCYTNHALDQFLEGLLDFGPTKIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 577 RLLApsrdirmvpeDIKPCCNWDAKKgeyvfpakkklqeYRVLITTLitagrlvsaQFPIdhfthIFIDEAGHCMEPESL 656
Cdd:cd17936 79 RLGA----------RVIGMTTTGAAK-------------YRELLQAL---------GPKV-----VIVEEAAEVLEAHIL 121
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 1610576131 657 VAIAGLMEvketgdpggQLVLAGDPRQLGP-VLRSPLTQK-HGLGYSLLERL 706
Cdd:cd17936 122 AALTPSTE---------HLILIGDHKQLRPkVNVYELTAKkYNLDVSLFERL 164
|
|
| COG3972 |
COG3972 |
Superfamily I DNA and RNA helicases [Replication, recombination and repair]; |
430-920 |
1.04e-07 |
|
Superfamily I DNA and RNA helicases [Replication, recombination and repair];
Pssm-ID: 443172 [Multi-domain] Cd Length: 565 Bit Score: 55.99 E-value: 1.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 430 SMSLLSRFVDGLTFKVNFTFNRQPLRVQHRALELTGRWLLWPMLF----------PVAPRDVPLLPSDVKLKLYDRSLES 499
Cdd:COG3972 72 VLVASSGAEQVVLDGVRALFEVLLQVDRESVRNLTEDHLRSLRLLaasrrdflfaLLLPEIPPAPFVQALRLLNLVSLED 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 500 NP---------EQLQAMRHIVTGTTRpapyiIFGPPGTGKTVTLVEAIKQVVKHLPKAHILA-CApSNSgadlLCQRLRV 569
Cdd:COG3972 152 FFlpliavldlQQERIARSIPDGPQR-----IRGVAGSGKTVLLAAKAAYLALKHPGWRILVtCF-NRS----LADHLRD 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 570 HLPSSIYRLLAPSrdirmVPEDIKPCCN--WDAKKGEY----VFPAKKKLQEYRVLITTLITAGRLVSAQFPIDHfthIF 643
Cdd:COG3972 222 LIPRFLRRFSNGE-----PEDNVKLIVFhaWGGKLLKQygipPLTFSQPNEAFDEACKALLEAIQGEIIPPIYDA---IL 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 644 IDEAgHCMEPESLVAIAGLMEvketgDPGGQLVLAGDPRQlgpvlrspltqkhglgysllerlltynSLYKK---GPDGY 720
Cdd:COG3972 294 IDEA-QDFEPEFLRLLYQLLK-----PPKKRLIWAYDEAQ---------------------------NIYGRkipSAGGI 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 721 DPQF--ITKLLRNYRSHPTILDIPNQLY-----YEGELQACADVVDRERFCRWAGLPRQGFPIIfhgvmgkdeREGNSPS 793
Cdd:COG3972 341 PAGIgrDTILKKNYRNTRPILTFAHAFGmgllrPPGLLQGDAEDYEVERPGDKVTLIRPPEPAG---------RKGPLPE 411
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 794 FF---NPEE--AATVTSYLKLLLApsskkgkARLSPRSVGVI----SPYRKQVEKIRYCITKLDRELRGLDDIKD----- 859
Cdd:COG3972 412 FKkydDRAEelEAIAEEIKKNLRD-------EGLRPSDIAVIylgnNEAKELGDRLAAALERQGIDSYIAGARSDpnffw 484
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1610576131 860 ----LKVGSVEEFQGQERSVILISTVRSSQSFVQLDLDFNLGFlknpkrfnVAVTRAKALLIIVG 920
Cdd:COG3972 485 kdggVTISTIHRAKGLEAPVVIIVGLDQLAKGESLERLRNLLY--------VAMTRARGWLVVSG 541
|
|
| SF1_C |
cd18786 |
C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family ... |
825-920 |
1.78e-06 |
|
C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Similar to SF2 helicases, they do not form toroidal, predominantly hexameric structures like SF3-6. SF1 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350173 [Multi-domain] Cd Length: 89 Bit Score: 47.05 E-value: 1.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 825 RSVGVISPYRKQVEKIRYCITKLDRELrglDDIKDLKVGSVEEFQGQERSVILISTVRSsqsfvqldldfnlgFLKNPKR 904
Cdd:cd18786 11 YKGVVLTPYHRDRAYLNQYLQGLSLDE---FDLQLVGAITIDSSQGLTFDVVTLYLPTA--------------NSLTPRR 73
|
90
....*....|....*.
gi 1610576131 905 FNVAVTRAKALLIIVG 920
Cdd:cd18786 74 LYVALTRARKRLVIYD 89
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
500-655 |
2.76e-06 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 49.03 E-value: 2.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 500 NPEQLQAMRHIVTGTTRpapYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACAPSNSGADLLCQRLRVHLPSSiyrll 579
Cdd:smart00487 10 RPYQKEAIEALLSGLRD---VILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPTRELAEQWAEELKKLGPSL----- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 580 apsrdirmvpeDIKPCCNWDAKKGEYVFpAKKKLQEYRVLITTLitaGRLVSA----QFPIDHFTHIFIDEAgHCMEPES 655
Cdd:smart00487 82 -----------GLKVVGLYGGDSKREQL-RKLESGKTDILVTTP---GRLLDLlendKLSLSNVDLVILDEA-HRLLDGG 145
|
|
| EEXXQc_AQR |
cd17935 |
EEXXQ-box helicase domain of AQR; Aquarius (AQR) is a multifunctional RNA helicase that binds ... |
495-746 |
1.53e-05 |
|
EEXXQ-box helicase domain of AQR; Aquarius (AQR) is a multifunctional RNA helicase that binds precursor-mRNA introns at a defined position and is part of a pentameric intron-binding complex (IBC). It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350693 [Multi-domain] Cd Length: 207 Bit Score: 47.04 E-value: 1.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 495 RSLESNPEQLQAmrhIVTGTtRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACAPSNSGADLLCQ---RLRV-- 569
Cdd:cd17935 2 NTVKFTPTQIEA---IRSGM-QPGLTMVVGPPGTGKTDVAVQIISNLYHNFPNQRTLIVTHSNQALNQLFEkimALDIde 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 570 -HLpssiYRLLAPSRDIRMVpedikpCCNWDAKKGEyvfpakkklqeyrvlittlitagrLVSAQFpidHFTHIFIDEAG 648
Cdd:cd17935 78 rHL----LRLGHGAKIIAMT------CTHAALKRGE------------------------LVELGF---KYDNILMEEAA 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 649 HCMEPESLVAIagLMEVKETGdPGG--QLVLAGDPRQLGPVLRSPLTQKHG-LGYSLLERLLTYNSlykkgpdgydpqFI 725
Cdd:cd17935 121 QILEIETFIPL--LLQNPEDG-PNRlkRLIMIGDHHQLPPVIKNMAFQKYSnMEQSLFTRLVRLGV------------PT 185
|
250 260
....*....|....*....|.
gi 1610576131 726 TKLLRNYRSHPTILDIPNQLY 746
Cdd:cd17935 186 VDLDAQGRARASISSLYNWRY 206
|
|
| DExxQc_SF1-N |
cd17914 |
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members ... |
521-561 |
2.02e-05 |
|
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Like SF2, they do not form toroidal, predominantly hexameric structures like SF3-6. Their helicase core is surrounded by C and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains or domains engaged in protein-protein interactions. SF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438706 [Multi-domain] Cd Length: 121 Bit Score: 44.78 E-value: 2.02e-05
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 1610576131 521 IIFGPPGTGKTVTLVEAIKQVV--KHLPKAHILACAPSNSGAD 561
Cdd:cd17914 3 LIQGPPGTGKTRVLVKIVAALMqnKNGEPGRILLVTPTNKAAA 45
|
|
| betaCoV_Nsp13-helicase |
cd21722 |
helicase domain of betacoronavirus non-structural protein 13; This model represents the ... |
524-924 |
4.39e-05 |
|
helicase domain of betacoronavirus non-structural protein 13; This model represents the helicase domain of non-structural protein 13 (Nsp13) from betacoronavirus, including pathogenic human viruses such as Severe acute respiratory syndrome coronavirus (SARS-CoV), SARS-CoV2 (also called 2019 novel CoV or 2019-nCoV), and Middle East respiratory syndrome-related (MERS) CoV. Helicases catalyze NTP-dependent unwinding of nucleic acid duplexes into single strands and are classified based on the arrangement of conserved motifs into six superfamilies. CoV Nsp13 is a member of the helicase superfamily 1 (SF1); SF1 and SF2 helicases do not form toroidal structures, while SF3-6 helicases do. Nsp13 is a component of the viral RNA synthesis replication and transcription complex (RTC). It is a multidomain protein containing a Cys/His rich zinc-binding domain (CH/ZBD), a stalk domain, a 1B domain involved in nucleic acid substrate binding, and a SF1 helicase core.
Pssm-ID: 409655 [Multi-domain] Cd Length: 340 Bit Score: 46.72 E-value: 4.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 524 GPPGTGKTVTlveAIKQVVkHLPKAHILACAPSNSGADLLCQRlrvhlpssIYRLLAPSRDIRMVPEDIKPCCnWDAKK- 602
Cdd:cd21722 32 GPPGTGKSHL---AIGLAV-YYPTARVVYTACSHAAVDALCEK--------AFKFLNINKCSRIIPAKARVEC-YDKFKv 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 603 ----GEYVFPAKKKLQEyrvlittlITAGRLVsaqfpidhfthifIDEAGHCMEPEsLVAIAGLMEVKetgdpggQLVLA 678
Cdd:cd21722 99 ndtsRQYVFSTINALPE--------TVTDILV-------------VDEVSMCTNYD-LSVINARVRAK-------HIVYI 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 679 GDPRQLgPVLRSPLTQKhglgySLLERllTYNSLYK----KGPDGYdpqfitkLLRNYRSHPTILDIPNQLYYEGELQAC 754
Cdd:cd21722 150 GDPAQL-PAPRTLLTKG-----TLEPE--YFNSVTRlmccLGPDIF-------LGTCYRCPKEIVDTVSALVYDNKLKAK 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 755 ADvvdrerfcrwagLPRQGFPIIFHGVMGKDeregnSPSFFNPEEAATVTSYLKlllapsskkgkARLSPRSVGVISPYR 834
Cdd:cd21722 215 KD------------NSGQCFKVYYKGSVTHD-----SSSAINRPQIYLVKKFLK-----------ANPAWSKAVFISPYN 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 835 KQvekiryciTKLDRELRGLddikdlKVGSVEEFQGQERS-VILISTVRSSQSFvqldldfnlgflkNPKRFNVAVTRA- 912
Cdd:cd21722 267 SQ--------NAVARRVLGL------QTQTVDSSQGSEYDyVIYCQTAETAHSV-------------NVNRFNVAITRAk 319
|
410
....*....|..
gi 1610576131 913 KALLIIVGNPLL 924
Cdd:cd21722 320 KGILCVMSSMQL 331
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
521-677 |
5.64e-04 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 41.23 E-value: 5.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 521 IIFGPPGTGKTVTLVEAIKQV-VKHLPKAHILacAPSNSGADLLCQRLRvhlpssiyRLLAPSRDIRMvpedikpcCNWD 599
Cdd:cd00046 5 LITAPTGSGKTLAALLAALLLlLKKGKKVLVL--VPTKALALQTAERLR--------ELFGPGIRVAV--------LVGG 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 600 AKKGEyvfPAKKKLQEYRVLITTLITAGRLVSA--QFPIDHFTHIFIDEAgHCMEPESLVAIAGLMEVKETGDPGGQLVL 677
Cdd:cd00046 67 SSAEE---REKNKLGDADIIIATPDMLLNLLLRedRLFLKDLKLIIVDEA-HALLIDSRGALILDLAVRKAGLKNAQVIL 142
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
500-649 |
1.07e-03 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 40.73 E-value: 1.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 500 NPEQLQAMR----HIVTGTTRpapYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACAPSNSgadlLCQRLRVHlpssi 575
Cdd:pfam04851 5 RPYQIEAIEnlleSIKNGQKR---GLIVMATGSGKTLTAAKLIARLFKKGPIKKVLFLVPRKD----LLEQALEE----- 72
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1610576131 576 YRLLAPsrDIRMVPEDIKPCCNwdakkgeyvfpaKKKLQEYRVLITTLITAGRLVSA---QFPIDHFTHIFIDEAGH 649
Cdd:pfam04851 73 FKKFLP--NYVEIGEIISGDKK------------DESVDDNKIVVTTIQSLYKALELaslELLPDFFDVIIIDEAHR 135
|
|
| AAA_19 |
pfam13245 |
AAA domain; |
508-687 |
2.80e-03 |
|
AAA domain;
Pssm-ID: 433059 [Multi-domain] Cd Length: 136 Bit Score: 39.12 E-value: 2.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 508 RHIVTGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVK-HLPKAHILACAPSNSGADLLCQRLrvHLPSS-IYRLLapsrdi 585
Cdd:pfam13245 2 REAVRTALPSKVVLLTGGPGTGKTTTIRHIVALLVAlGGVSFPILLAAPTGRAAKRLSERT--GLPAStIHRLL------ 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 586 rmvpedikpccNWDAkkgeyvfpakkklqeyrvlittLITAGRLVSAQFPIDHFtHIFIDEAghcmepeSLVAIAGLMEV 665
Cdd:pfam13245 74 -----------GFDD----------------------LEAGGFLRDEEEPLDGD-LLIVDEF-------SMVDLPLAYRL 112
|
170 180
....*....|....*....|..
gi 1610576131 666 KETGDPGGQLVLAGDPRQLGPV 687
Cdd:pfam13245 113 LKALPDGAQLLLVGDPDQLPSV 134
|
|
| deltaCoV_Nsp13-helicase |
cd21721 |
helicase domain of deltacoronavirus non-structural protein 13; This model represents the ... |
483-583 |
2.82e-03 |
|
helicase domain of deltacoronavirus non-structural protein 13; This model represents the helicase domain of non-structural protein 13 (Nsp13) from deltacoronavirus, including Bulbul coronavirus (CoV) HKU11 and Common moorhen CoV HKU21. Helicases catalyze NTP-dependent unwinding of nucleic acid duplexes into single strands and are classified based on the arrangement of conserved motifs into six superfamilies. CoV Nsp13 is a member of the helicase superfamily 1 (SF1); SF1 and SF2 helicases do not form toroidal structures, while SF3-6 helicases do. Nsp13 is a component of the viral RNA synthesis replication and transcription complex (RTC). It is a multidomain protein containing a Cys/His rich zinc-binding domain (CH/ZBD), a stalk domain, a 1B domain involved in nucleic acid substrate binding, and a SF1 helicase core.
Pssm-ID: 409654 [Multi-domain] Cd Length: 342 Bit Score: 41.06 E-value: 2.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 483 LLPSDVKLKLYDRSLESNPEQlqAMRHIVTgttrpapyiIFGPPGTGKTVTLVeaikQVVKHLPKAHILACAPSNSGADL 562
Cdd:cd21721 2 LIPDTVGASFYVQHFKSYNEI--AMQKVTT---------VLGPPGTGKSTFAI----GLAKYYPNARICYTASSHAAIDA 66
|
90 100
....*....|....*....|.
gi 1610576131 563 LCQRLRVHLPSSIYRLLAPSR 583
Cdd:cd21721 67 LCEKAFKTLPVGQCSRIVPTR 87
|
|
| UvrD |
COG0210 |
Superfamily I DNA or RNA helicase [Replication, recombination and repair]; |
500-580 |
8.50e-03 |
|
Superfamily I DNA or RNA helicase [Replication, recombination and repair];
Pssm-ID: 439980 [Multi-domain] Cd Length: 721 Bit Score: 39.92 E-value: 8.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576131 500 NPEQLQAMRHIvtgttrPAPYIIFGPPGTGKTVTLVEAIKQVV--KHLPKAHILACAPSNSGADLLCQRLRVHLPSSIYR 577
Cdd:COG0210 8 NPEQRAAVEHP------EGPLLVLAGAGSGKTRVLTHRIAYLIaeGGVDPEQILAVTFTNKAAREMRERIEALLGRLARG 81
|
...
gi 1610576131 578 LLA 580
Cdd:COG0210 82 LWV 84
|
|
| AAA |
smart00382 |
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ... |
516-570 |
9.87e-03 |
|
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.
Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 37.74 E-value: 9.87e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1610576131 516 RPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACAPSNSGADLLCQRLRVH 570
Cdd:smart00382 1 PGEVILIVGPPGSGKTTLARALARELGPPGGGVIYIDGEDILEEVLDQLLLIIVG 55
|
|
| |
