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Conserved domains on  [gi|1610576314|ref|NP_001356419|]
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regulator of hemoglobinization and erythroid cell expansion protein [Homo sapiens]

Protein Classification

regulator of hemoglobinization and erythroid cell expansion protein( domain architecture ID 11239068)

regulator of hemoglobinization and erythroid cell expansion (RHEX) protein is a DUF4692 domain-containing protein that acts as a signaling transduction factor of the EPO-EPOR signaling pathway promoting erythroid cell differentiation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4692 pfam15763
Regulator of human erythroid cell expansion (RHEX); This family of proteins is found in ...
 7-172 3.34e-96

Regulator of human erythroid cell expansion (RHEX); This family of proteins is found in eukaryotes. Family members include human RHEX proteins which regulates erythroid progenitor cell expansion and erythroblast development.


:

Pssm-ID: 434917  Cd Length: 166  Bit Score: 275.54  E-value: 3.34e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576314   7 EVWHGLVIAVVSLFLQACFLTAINYLLSRHMAHKSEQILKAASLQVPRPSPGHHHPPAVKEMKeTQTERDIPMSDSLYRH 86
Cdd:pfam15763   1 ELWHGLVIAVVSLFLQACLLAAINYLLSRHMAKESERILKAARLQAPRPSPAHHHPPAAKEMK-TRAERSTPVSEPRYRH 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576314  87 DSDTPSDSL-DSSCSSPPACQATEDVDYTQVVFSDPGELKNDSPLDYENIKEITDYVNVNPERHKPSFWYFVNPALSEPA 165
Cdd:pfam15763  80 DSDTSSDSSdSSDSSSPPTSQATKDVNYTQVVFSAPGGLKNESALDYENIKETTDYVNVNPKSHKPNFWTFVNPAVSEPV 159


                  ....*..
gi 1610576314 166 EYDQVAM 172
Cdd:pfam15763 160 EYTQVAM 166
 
Name Accession Description Interval E-value
DUF4692 pfam15763
Regulator of human erythroid cell expansion (RHEX); This family of proteins is found in ...
 7-172 3.34e-96

Regulator of human erythroid cell expansion (RHEX); This family of proteins is found in eukaryotes. Family members include human RHEX proteins which regulates erythroid progenitor cell expansion and erythroblast development.


Pssm-ID: 434917  Cd Length: 166  Bit Score: 275.54  E-value: 3.34e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576314   7 EVWHGLVIAVVSLFLQACFLTAINYLLSRHMAHKSEQILKAASLQVPRPSPGHHHPPAVKEMKeTQTERDIPMSDSLYRH 86
Cdd:pfam15763   1 ELWHGLVIAVVSLFLQACLLAAINYLLSRHMAKESERILKAARLQAPRPSPAHHHPPAAKEMK-TRAERSTPVSEPRYRH 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576314  87 DSDTPSDSL-DSSCSSPPACQATEDVDYTQVVFSDPGELKNDSPLDYENIKEITDYVNVNPERHKPSFWYFVNPALSEPA 165
Cdd:pfam15763  80 DSDTSSDSSdSSDSSSPPTSQATKDVNYTQVVFSAPGGLKNESALDYENIKETTDYVNVNPKSHKPNFWTFVNPAVSEPV 159


                  ....*..
gi 1610576314 166 EYDQVAM 172
Cdd:pfam15763 160 EYTQVAM 166
 
Name Accession Description Interval E-value
DUF4692 pfam15763
Regulator of human erythroid cell expansion (RHEX); This family of proteins is found in ...
 7-172 3.34e-96

Regulator of human erythroid cell expansion (RHEX); This family of proteins is found in eukaryotes. Family members include human RHEX proteins which regulates erythroid progenitor cell expansion and erythroblast development.


Pssm-ID: 434917  Cd Length: 166  Bit Score: 275.54  E-value: 3.34e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576314   7 EVWHGLVIAVVSLFLQACFLTAINYLLSRHMAHKSEQILKAASLQVPRPSPGHHHPPAVKEMKeTQTERDIPMSDSLYRH 86
Cdd:pfam15763   1 ELWHGLVIAVVSLFLQACLLAAINYLLSRHMAKESERILKAARLQAPRPSPAHHHPPAAKEMK-TRAERSTPVSEPRYRH 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610576314  87 DSDTPSDSL-DSSCSSPPACQATEDVDYTQVVFSDPGELKNDSPLDYENIKEITDYVNVNPERHKPSFWYFVNPALSEPA 165
Cdd:pfam15763  80 DSDTSSDSSdSSDSSSPPTSQATKDVNYTQVVFSAPGGLKNESALDYENIKETTDYVNVNPKSHKPNFWTFVNPAVSEPV 159


                  ....*..
gi 1610576314 166 EYDQVAM 172
Cdd:pfam15763 160 EYTQVAM 166
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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