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Conserved domains on  [gi|1598230890|ref|NP_001356140|]
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tenascin isoform 1 precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
1889-2098 1.97e-113

Fibrinogen beta and gamma chains, C-terminal globular domain;


:

Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 359.14  E-value: 1.97e-113
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1889 FPRDCSQAMLNGDTTSGLYTIYINGDKTQaLEVYCDMTSDGGGWIVFLRRKNGREDFYRNWKAYAAGFGD-RREEFWLGL 1967
Cdd:pfam00147    1 FGRDCSDVYNKGAKTSGLYTIRPDGATKP-FEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNlSPGEFWLGN 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1968 DNLSKITAQGQYELRVDLQDH-GESAYAVYDRFSVGDAKSRYKLKVEGYSGTAGD-------SMNYHNGRSFSTYDKDTD 2039
Cdd:pfam00147   80 DKIHLLTKQGPYVLRIDLEDWnGETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDND 159

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1598230890 2040 SAITNCALSYKGAFWYKNCHRVNLMGRY--GDNNHSQ-GVNWFHWKGHEYSIQFAEMKLRPS 2098
Cdd:pfam00147  160 SPDGNCALSYGGGWWYNNCHAANLNGVYyyGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
861-1244 2.19e-22

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 104.31  E-value: 2.19e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  861 GNLRPDTEYEVSLISRRVDMASNPAKE----TFITGLDAPRNLRRVSQTDNSITLEWRNVKA-DIDSYRIKYAPISGGDH 935
Cdd:COG3401    197 GDIEPGTTYYYRVAATDTGGESAPSNEvsvtTPTTPPSAPTGLTATADTPGSVTLSWDPVTEsDATGYRVYRSNSGDGPF 276

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  936 AEIdvpksqqATTKTTL---TGLRPGTEYGIGVSAVKGDKE----SDPATINAATEI-DAPKDLRVSETTQDSLTFFWT- 1006
Cdd:COG3401    277 TKV-------ATVTTTSytdTGLTNGTTYYYRVTAVDAAGNesapSNVVSVTTDLTPpAAPSGLTATAVGSSSITLSWTa 349

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1007 TPLAKFDRYRLNYSLPTGQSME-VQLPKDATSHVLTDLEPGQEYTVLLIA--EKGRHKSKPARVKASTEEVPSLENLTVT 1083
Cdd:COG3401    350 SSDADVTGYNVYRSTSGGGTYTkIAETVTTTSYTDTGLTPGTTYYYKVTAvdAAGNESAPSEEVSATTASAASGESLTAS 429

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1084 EAGWDGLR-LNWTADDLAYEYFVIQVQEANNVETAHNFTVPGNLRAADIPGLKVATSYRVSIYGVARGYRTpvlSAETST 1162
Cdd:COG3401    430 VDAVPLTDvAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGS---GASSVT 506

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1163 GTTPNLGEVTVAEVGWdalTLNWTAPEGAYKNFFIQVLEADTTQTVQNLTVPGGLRSVDLPGLKAATRYYITLRGVTQDF 1242
Cdd:COG3401    507 NSVSVIGASAAAAVGG---APDGTPNVTGASPVTVGASTGDVLITDLVSLTTSASSSVSGAGLGSGNLYLITTLGGSLLT 583


                   ..
gi 1598230890 1243 GT 1244
Cdd:COG3401    584 TT 585
fn3 pfam00041
Fibronectin type III domain;
1797-1869 2.69e-14

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 70.14  E-value: 2.69e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1598230890 1797 DSPREFTATEVQSETALLTWRPPR---ASVTGYLLVYESVDGT--VKEVIVGPDTTSYSLADLSPSTHYSARIQALSG 1869
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 624-710 8.37e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.06  E-value: 8.37e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  624 SPPKDLIVTEVTEETVNLAW----DNEMRVTEYLIMYTPTHADGLEMQFRVPGDQTSTTIRELEPGVEYFIRVFAILENK 699
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWtppeDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|.
gi 1598230890  700 RSIPVSARVAT 710
Cdd:cd00063     82 ESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
1530-1610 7.33e-13

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.90  E-value: 7.33e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1530 PEVDNLLVSDATPDGFRLSWTADE---GIFDSFVIRIRDTKKQSEPQEISLPSPERTRDITGLREATEYEIELYGISRGR 1606
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1598230890 1607 RSQP 1610
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
1257-1336 2.76e-12

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 2.76e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1257 PQLGGLSVTEVSWDGLTLNWT---TDDLAYKHFVVQVQEANNVEAAQNLTVPGSLRAVDIPGLKADTPYRVSIYGVIQGY 1333
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ...
gi 1598230890 1334 RTP 1336
Cdd:pfam00041   81 EGP 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1620-1706 5.58e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 63.67  E-value: 5.58e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1620 GSPKEIMFSDITENAATVSWRAPT---AQVESFRITYVPMTGGAPSMVTV-DGTDTETRLVKLTPGVEYRVSVIAMKGFE 1695
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVtPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|.
gi 1598230890 1696 ESDPVSGTLIT 1706
Cdd:cd00063     82 ESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
713-793 7.84e-12

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.82  E-value: 7.84e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  713 PAPEGLKFKSIKETSVEVEWDP---LDIAFETWEIIFRNMNKEDEgEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNN 789
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEP-WNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....
gi 1598230890  790 TRGP 793
Cdd:pfam00041   80 GEGP 83
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
1322-1888 2.32e-11

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 68.88  E-value: 2.32e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1322 YRVSIYGVIQGYRTPMLSTDVSTAREPEIGNLNVSDVTPKSFNLSWTATDGIFDMFTIEI-IDSNRLLQTAEHNISGAER 1400
Cdd:COG3401     24 NALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAvAAAPPTATGLTTLTGSGSV 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1401 TAHISGLPPSTDFIVYLSGIAPSIRTKTISTTATTEALPLLENLTISDTNPYGFTVSWTASENAFDSFLVTVVDSGKLLD 1480
Cdd:COG3401    104 GGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATT 183

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1481 pqEFTLSGTQRKLELRGLITGIGYEVLVSGFTQGHQTKP---LRAETITEAEPEVDNLLVSDATPDGFRLSWTA--DEGI 1555
Cdd:COG3401    184 --SLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPsneVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPvtESDA 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1556 fDSFVIRiRDTKKQSEPQEISLPSPERTRDiTGLREATEYEielYGIS----RGRRSQPVSAIATTAMGS----PKEIMF 1627
Cdd:COG3401    262 -TGYRVY-RSNSGDGPFTKVATVTTTSYTD-TGLTNGTTYY---YRVTavdaAGNESAPSNVVSVTTDLTppaaPSGLTA 335

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1628 SDITENAATVSWRAPT-AQVESFRITYVPMTGGAPSMVTVDGTDTETRLVKLTPGVEYRVSVIAM----KGFEESDPVSG 1702
Cdd:COG3401    336 TAVGSSSITLSWTASSdADVTGYNVYRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVdaagNESAPSEEVSA 415

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1703 TLITALDGPSGLLIANITDSEALAMWQPAIATVDSYVISYTGERVPEVTRTVSGNTVEYELHDLEPATEYiLSIFAEKGQ 1782
Cdd:COG3401    416 TTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTT-TANLSVTTG 494

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1783 QKSSTIATKFTTDLDSPREFTATEVQSETalLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYSA 1862
Cdd:COG3401    495 SLVGGSGASSVTNSVSVIGASAAAAVGGA--PDGTPNVTGASPVTVGASTGDVLITDLVSLTTSASSSVSGAGLGSGNLY 572

                          570       580
                   ....*....|....*....|....*.
gi 1598230890 1863 RIQALSGSLRSKLIQTIFTTIGLLYP 1888
Cdd:COG3401    573 LITTLGGSLLTTTSTNTNDVAGVHGG 598
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 804-891 7.37e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.51  E-value: 7.37e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  804 DAPSHIEVKDVTDTTALITWFKPL---AEIDSIELSYGIKDVPGDRTTIDLTHEDNQYSIGNLRPDTEYEVSLISRRVDM 880
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|.
gi 1598230890  881 ASNPAKETFIT 891
Cdd:cd00063     82 ESPPSESVTVT 92
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 408-435 1.39e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 46.52  E-value: 1.39e-06
                           10        20
                   ....*....|....*....|....*...
gi 1598230890  408 CPNGCSGHGRCVNGQCVCDEGYTGEDCS 435
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 190-217 9.19e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 44.21  E-value: 9.19e-06
                           10        20
                   ....*....|....*....|....*...
gi 1598230890  190 CPGNCNLRGQCLDGQCICDEGFTGEDCS 217
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 501-528 1.33e-05

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 43.83  E-value: 1.33e-05
                           10        20
                   ....*....|....*....|....*...
gi 1598230890  501 CPRDCSQRGRCVDGQCICEDGFTGPDCA 528
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 470-496 1.76e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 40.36  E-value: 1.76e-04
                           10        20
                   ....*....|....*....|....*..
gi 1598230890  470 CPNDCHQHGRCVNGMCICDDDYTGEDC 496
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 594-621 3.14e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 39.59  E-value: 3.14e-04
                           10        20
                   ....*....|....*....|....*...
gi 1598230890  594 CPNDCSNQGQCVSGRCICNEGYTGIDCS 621
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 439-466 6.31e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 38.82  E-value: 6.31e-04
                           10        20
                   ....*....|....*....|....*...
gi 1598230890  439 CPNDCHNRGLCVQGKCICEQGFKGFDCS 466
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 535-558 9.53e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.48  E-value: 9.53e-04
                           10        20
                   ....*....|....*....|....*.
gi 1598230890  535 DCHGHGRCVN--GQCICHEGFTGKDC 558
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 346-373 1.23e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 38.05  E-value: 1.23e-03
                           10        20
                   ....*....|....*....|....*...
gi 1598230890  346 CPNDCQGRGQCEEGQCVCNEGFAGADCS 373
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 380-403 1.36e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 37.71  E-value: 1.36e-03
                           10        20
                   ....*....|....*....|....*.
gi 1598230890  380 DCHHRGRC--LNGQCECDDGFTGADC 403
Cdd:pfam07974    1 ICSGRGTCvnQCGKCVCDSGYQGATC 26
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 252-280 3.77e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 36.89  E-value: 3.77e-03
                           10        20
                   ....*....|....*....|....*....
gi 1598230890  252 CPVPCSEEhGMCVDGRCVCKDGFAGEDCN 280
Cdd:pfam18720    2 CPLGCSSR-GVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 284-311 6.41e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 36.12  E-value: 6.41e-03
                           10        20
                   ....*....|....*....|....*...
gi 1598230890  284 CLNNCYNRGRCVENECVCDEGFTGEDCS 311
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 563-589 9.51e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 35.74  E-value: 9.51e-03
                           10        20
                   ....*....|....*....|....*..
gi 1598230890  563 CPSDCHGQGRCEDGQCICHEGFTGLDC 589
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
 
Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
1889-2098 1.97e-113

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 359.14  E-value: 1.97e-113
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1889 FPRDCSQAMLNGDTTSGLYTIYINGDKTQaLEVYCDMTSDGGGWIVFLRRKNGREDFYRNWKAYAAGFGD-RREEFWLGL 1967
Cdd:pfam00147    1 FGRDCSDVYNKGAKTSGLYTIRPDGATKP-FEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNlSPGEFWLGN 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1968 DNLSKITAQGQYELRVDLQDH-GESAYAVYDRFSVGDAKSRYKLKVEGYSGTAGD-------SMNYHNGRSFSTYDKDTD 2039
Cdd:pfam00147   80 DKIHLLTKQGPYVLRIDLEDWnGETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDND 159

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1598230890 2040 SAITNCALSYKGAFWYKNCHRVNLMGRY--GDNNHSQ-GVNWFHWKGHEYSIQFAEMKLRPS 2098
Cdd:pfam00147  160 SPDGNCALSYGGGWWYNNCHAANLNGVYyyGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 1889-2097 5.91e-110

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 348.88  E-value: 5.91e-110
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  1889 FPRDCSQAMLNGDTTSGLYTIYINGDkTQALEVYCDMTSDGGGWIVFLRRKNGREDFYRNWKAYAAGFGDRREEFWLGLD 1968
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDGS-SRPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  1969 NLSKITAQGQYELRVDLQD-HGESAYAVYDRFSVGDAKSRYKLKVEGYSGTAGD-SMNYHNGRSFSTYDKDTDSAITNCA 2046
Cdd:smart00186   80 NIHLLTSQGKYELRIDLEDwEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1598230890  2047 LSYKGAFWYKNCHRVNLMGRYG-DNNHSQGVNWFHWKGHEYSIQFAEMKLRP 2097
Cdd:smart00186  160 EEYGGGWWYNNCHAANLNGRYYpNNNYDNGINWATWKGSWYSLKFTEMKIRP 211
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 1888-2097 1.45e-109

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 347.69  E-value: 1.45e-109
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1888 PFPRDCSQAMLNGDTTSGLYTIYINGDKtQALEVYCDMTSDGGGWIVFLRRKNGREDFYRNWKAYAAGFGDRREEFWLGL 1967
Cdd:cd00087      1 PLPRDCSEVLQRGGRTSGVYTIQPPGSN-EPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1968 DNLSKITAQGQYELRVDLQD-HGESAYAVYDRFSVGDAKSRYKLKVEGYSGTAGDSMNYHNGRSFSTYDKDTDSAITNCA 2046
Cdd:cd00087     80 EKIHLLTSQGPYELRIDLEDwEGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGNCA 159

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1598230890 2047 LSYKGAFWYKNCHRVNLMGRYG----DNNHSQGVNWFHWKGHEYSIQFAEMKLRP 2097
Cdd:cd00087    160 ESYSGGWWYNSCHASNLNGRYYsgghRNEYDNGINWATWKGSTYSLKFTEMKIRP 214
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
861-1244 2.19e-22

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 104.31  E-value: 2.19e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  861 GNLRPDTEYEVSLISRRVDMASNPAKE----TFITGLDAPRNLRRVSQTDNSITLEWRNVKA-DIDSYRIKYAPISGGDH 935
Cdd:COG3401    197 GDIEPGTTYYYRVAATDTGGESAPSNEvsvtTPTTPPSAPTGLTATADTPGSVTLSWDPVTEsDATGYRVYRSNSGDGPF 276

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  936 AEIdvpksqqATTKTTL---TGLRPGTEYGIGVSAVKGDKE----SDPATINAATEI-DAPKDLRVSETTQDSLTFFWT- 1006
Cdd:COG3401    277 TKV-------ATVTTTSytdTGLTNGTTYYYRVTAVDAAGNesapSNVVSVTTDLTPpAAPSGLTATAVGSSSITLSWTa 349

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1007 TPLAKFDRYRLNYSLPTGQSME-VQLPKDATSHVLTDLEPGQEYTVLLIA--EKGRHKSKPARVKASTEEVPSLENLTVT 1083
Cdd:COG3401    350 SSDADVTGYNVYRSTSGGGTYTkIAETVTTTSYTDTGLTPGTTYYYKVTAvdAAGNESAPSEEVSATTASAASGESLTAS 429

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1084 EAGWDGLR-LNWTADDLAYEYFVIQVQEANNVETAHNFTVPGNLRAADIPGLKVATSYRVSIYGVARGYRTpvlSAETST 1162
Cdd:COG3401    430 VDAVPLTDvAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGS---GASSVT 506

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1163 GTTPNLGEVTVAEVGWdalTLNWTAPEGAYKNFFIQVLEADTTQTVQNLTVPGGLRSVDLPGLKAATRYYITLRGVTQDF 1242
Cdd:COG3401    507 NSVSVIGASAAAAVGG---APDGTPNVTGASPVTVGASTGDVLITDLVSLTTSASSSVSGAGLGSGNLYLITTLGGSLLT 583


                   ..
gi 1598230890 1243 GT 1244
Cdd:COG3401    584 TT 585
fn3 pfam00041
Fibronectin type III domain;
894-976 6.00e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 71.68  E-value: 6.00e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  894 DAPRNLRRVSQTDNSITLEW---RNVKADIDSYRIKYAPISGGDHA-EIDVPKSqqaTTKTTLTGLRPGTEYGIGVSAVK 969
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWtppPDGNGPITGYEVEYRPKNSGEPWnEITVPGT---TTSVTLTGLKPGTEYEVRVQAVN 77


                   ....*..
gi 1598230890  970 GDKESDP 976
Cdd:pfam00041   78 GGGEGPP 84
fn3 pfam00041
Fibronectin type III domain;
1797-1869 2.69e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 70.14  E-value: 2.69e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1598230890 1797 DSPREFTATEVQSETALLTWRPPR---ASVTGYLLVYESVDGT--VKEVIVGPDTTSYSLADLSPSTHYSARIQALSG 1869
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 624-710 8.37e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.06  E-value: 8.37e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  624 SPPKDLIVTEVTEETVNLAW----DNEMRVTEYLIMYTPTHADGLEMQFRVPGDQTSTTIRELEPGVEYFIRVFAILENK 699
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWtppeDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|.
gi 1598230890  700 RSIPVSARVAT 710
Cdd:cd00063     82 ESPPSESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 894-978 2.94e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.14  E-value: 2.94e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  894 DAPRNLRRVSQTDNSITLEWRNVKAD---IDSYRIKYAPISGGDHAEIDVPKSQqaTTKTTLTGLRPGTEYGIGVSAVKG 970
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGS--ETSYTLTGLKPGTEYEFRVRAVNG 79


                   ....*...
gi 1598230890  971 DKESDPAT 978
Cdd:cd00063     80 GGESPPSE 87
fn3 pfam00041
Fibronectin type III domain;
1530-1610 7.33e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.90  E-value: 7.33e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1530 PEVDNLLVSDATPDGFRLSWTADE---GIFDSFVIRIRDTKKQSEPQEISLPSPERTRDITGLREATEYEIELYGISRGR 1606
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1598230890 1607 RSQP 1610
Cdd:pfam00041   81 EGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
638-997 1.05e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 73.50  E-value: 1.05e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  638 TVNLAWDNEMRVTEYLIMYTPTHADGLEMQFRVPGDQTSTTIRELEPGVEYFIRVFAILENKRSIP---VSARVATYLP- 713
Cdd:COG3401    155 ASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPsneVSVTTPTTPPs 234

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  714 APEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGE-ITKSlrrPETSYRQTGLAPGQEYeislhivknntrg 792
Cdd:COG3401    235 APTGLTATADTPGSVTLSWDPVTESDATGYRVYRSNSGDGPFTkVATV---TTTSYTDTGLTNGTTY------------- 298

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  793 pglkkvtttrldapshievkdvtdttalitwfkplaeidsielSYGIKDVpgdrttidlthednqysignlrpDTEYEVS 872
Cdd:COG3401    299 -------------------------------------------YYRVTAV-----------------------DAAGNES 312

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  873 lisrrvdMASNPAK-ETFITGLDAPRNLRRVSQTDNSITLEWRNVK-ADIDSYRIKYAPISGGDHAEIDVPKSqqaTTKT 950
Cdd:COG3401    313 -------APSNVVSvTTDLTPPAAPSGLTATAVGSSSITLSWTASSdADVTGYNVYRSTSGGGTYTKIAETVT---TTSY 382

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*...
gi 1598230890  951 TLTGLRPGTEYGIGVSAV-KGDKESDPATINAATEIDAPKDLRVSETT 997
Cdd:COG3401    383 TDTGLTPGTTYYYKVTAVdAAGNESAPSEEVSATTASAASGESLTASV 430
fn3 pfam00041
Fibronectin type III domain;
624-695 2.23e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 2.23e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1598230890  624 SPPKDLIVTEVTEETVNLAW----DNEMRVTEYLIMYTPTHADGLEMQFRVPGDQTSTTIRELEPGVEYFIRVFAI 695
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWtpppDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
fn3 pfam00041
Fibronectin type III domain;
1257-1336 2.76e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 2.76e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1257 PQLGGLSVTEVSWDGLTLNWT---TDDLAYKHFVVQVQEANNVEAAQNLTVPGSLRAVDIPGLKADTPYRVSIYGVIQGY 1333
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ...
gi 1598230890 1334 RTP 1336
Cdd:pfam00041   81 EGP 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
624-779 3.23e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 71.57  E-value: 3.23e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  624 SPPKDLIVTEVTEETVNLAWD--NEMRVTEYLImYTPTHADGlemQFRVPGDQTSTTI--RELEPGVEYFIRVFAILENK 699
Cdd:COG3401    234 SAPTGLTATADTPGSVTLSWDpvTESDATGYRV-YRSNSGDG---PFTKVATVTTTSYtdTGLTNGTTYYYRVTAVDAAG 309

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  700 R----SIPVSARVATYLP-APEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDE-GEITKSLRrpETSYRQTGL 773
Cdd:COG3401    310 NesapSNVVSVTTDLTPPaAPSGLTATAVGSSSITLSWTASSDADVTGYNVYRSTSGGGTyTKIAETVT--TTSYTDTGL 387


                   ....*.
gi 1598230890  774 APGQEY 779
Cdd:COG3401    388 TPGTTY 393
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1797-1869 4.46e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.79  E-value: 4.46e-12
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1598230890  1797 DSPREFTATEVQSETALLTWRPPRAS-----VTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYSARIQALSG 1869
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1620-1706 5.58e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 63.67  E-value: 5.58e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1620 GSPKEIMFSDITENAATVSWRAPT---AQVESFRITYVPMTGGAPSMVTV-DGTDTETRLVKLTPGVEYRVSVIAMKGFE 1695
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVtPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|.
gi 1598230890 1696 ESDPVSGTLIT 1706
Cdd:cd00063     82 ESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
713-793 7.84e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.82  E-value: 7.84e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  713 PAPEGLKFKSIKETSVEVEWDP---LDIAFETWEIIFRNMNKEDEgEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNN 789
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEP-WNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....
gi 1598230890  790 TRGP 793
Cdd:pfam00041   80 GEGP 83
fn3 pfam00041
Fibronectin type III domain;
1620-1699 2.18e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.66  E-value: 2.18e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1620 GSPKEIMFSDITENAATVSWRAPT---AQVESFRITYVPM-TGGAPSMVTVDGTDTETRLVKLTPGVEYRVSVIAMKGFE 1695
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKnSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1598230890 1696 ESDP 1699
Cdd:pfam00041   81 EGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1322-1888 2.32e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 68.88  E-value: 2.32e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1322 YRVSIYGVIQGYRTPMLSTDVSTAREPEIGNLNVSDVTPKSFNLSWTATDGIFDMFTIEI-IDSNRLLQTAEHNISGAER 1400
Cdd:COG3401     24 NALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAvAAAPPTATGLTTLTGSGSV 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1401 TAHISGLPPSTDFIVYLSGIAPSIRTKTISTTATTEALPLLENLTISDTNPYGFTVSWTASENAFDSFLVTVVDSGKLLD 1480
Cdd:COG3401    104 GGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATT 183

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1481 pqEFTLSGTQRKLELRGLITGIGYEVLVSGFTQGHQTKP---LRAETITEAEPEVDNLLVSDATPDGFRLSWTA--DEGI 1555
Cdd:COG3401    184 --SLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPsneVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPvtESDA 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1556 fDSFVIRiRDTKKQSEPQEISLPSPERTRDiTGLREATEYEielYGIS----RGRRSQPVSAIATTAMGS----PKEIMF 1627
Cdd:COG3401    262 -TGYRVY-RSNSGDGPFTKVATVTTTSYTD-TGLTNGTTYY---YRVTavdaAGNESAPSNVVSVTTDLTppaaPSGLTA 335

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1628 SDITENAATVSWRAPT-AQVESFRITYVPMTGGAPSMVTVDGTDTETRLVKLTPGVEYRVSVIAM----KGFEESDPVSG 1702
Cdd:COG3401    336 TAVGSSSITLSWTASSdADVTGYNVYRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVdaagNESAPSEEVSA 415

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1703 TLITALDGPSGLLIANITDSEALAMWQPAIATVDSYVISYTGERVPEVTRTVSGNTVEYELHDLEPATEYiLSIFAEKGQ 1782
Cdd:COG3401    416 TTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTT-TANLSVTTG 494

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1783 QKSSTIATKFTTDLDSPREFTATEVQSETalLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYSA 1862
Cdd:COG3401    495 SLVGGSGASSVTNSVSVIGASAAAAVGGA--PDGTPNVTGASPVTVGASTGDVLITDLVSLTTSASSSVSGAGLGSGNLY 572

                          570       580
                   ....*....|....*....|....*.
gi 1598230890 1863 RIQALSGSLRSKLIQTIFTTIGLLYP 1888
Cdd:COG3401    573 LITTLGGSLLTTTSTNTNDVAGVHGG 598
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1797-1882 5.05e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.97  E-value: 5.05e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1797 DSPREFTATEVQSETALLTWRPPR---ASVTGYLLVYESVD-GTVKEVIVGP-DTTSYSLADLSPSTHYSARIQALSGSL 1871
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGsGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 1598230890 1872 RSKLIQTI-FTT 1882
Cdd:cd00063     82 ESPPSESVtVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 624-701 1.05e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 59.55  E-value: 1.05e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890   624 SPPKDLIVTEVTEETVNLAWD--NEMRVTEYLIMYTPTH--ADGLEMQFRVPGDQTSTTIRELEPGVEYFIRVFAILENK 699
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEppPDDGITGYIVGYRVEYreEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1598230890   700 RS 701
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 986-1062 1.36e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 59.55  E-value: 1.36e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890   986 DAPKDLRVSETTQDSLTFFWTTP-----LAKFDRYRLNYSLPTGQSMEVQLPKDATSHVLTDLEPGQEYTVLLIAEKGRH 1060
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1598230890  1061 KS 1062
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 804-891 7.37e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.51  E-value: 7.37e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  804 DAPSHIEVKDVTDTTALITWFKPL---AEIDSIELSYGIKDVPGDRTTIDLTHEDNQYSIGNLRPDTEYEVSLISRRVDM 880
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|.
gi 1598230890  881 ASNPAKETFIT 891
Cdd:cd00063     82 ESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
1442-1514 9.08e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.04  E-value: 9.08e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1598230890 1442 ENLTISDTNPYGFTVSWTASEN---AFDSFLVTVVDSGKLLDPQEFTLSGTQRKLELRGLITGIGYEVLVSGFTQG 1514
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1620-1697 2.74e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.70  E-value: 2.74e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  1620 GSPKEIMFSDITENAATVSWRAPT-AQVESFRITYVPMTGGAPS---MVTVDGTDTETRLVKLTPGVEYRVSVIAMKGFE 1695
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPdDGITGYIVGYRVEYREEGSewkEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1598230890  1696 ES 1697
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1532-1617 3.37e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.97  E-value: 3.37e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1532 VDNLLVSDATPDGFRLSWTA---DEGIFDSFVIRIRDtKKQSEPQEISLPSPERTR-DITGLREATEYEIELYGISRGRR 1607
Cdd:cd00063      4 PTNLRVTDVTSTSVTLSWTPpedDGGPITGYVVEYRE-KGSGDWKEVEVTPGSETSyTLTGLKPGTEYEFRVRAVNGGGE 82

                           90
                   ....*....|
gi 1598230890 1608 SQPVSAIATT 1617
Cdd:cd00063     83 SPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 804-876 5.93e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.93  E-value: 5.93e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1598230890   804 DAPSHIEVKDVTDTTALITWFKPLAE-IDSIELSYGIKDVPGDR--TTIDLTHEDNQYSIGNLRPDTEYEVSLISR 876
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
fn3 pfam00041
Fibronectin type III domain;
804-884 8.17e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.34  E-value: 8.17e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  804 DAPSHIEVKDVTDTTALITWFKPL---AEIDSIELSYGIKDVPGDRTTIDLTHEDNQYSIGNLRPDTEYEVSLISRRVDM 880
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1598230890  881 ASNP 884
Cdd:pfam00041   81 EGPP 84
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 1899-1932 1.37e-08

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 52.56  E-value: 1.37e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1598230890 1899 NGDTTSGLYTIYINGD-KTQALEVYCDMTSDGGGW 1932
Cdd:NF040941     9 GPSAPSGVYWIDPDGMgGLAPFQVYCDMTTDGGGW 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 713-801 2.59e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.57  E-value: 2.59e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  713 PAPEGLKFKSIKETSVEVEWDPLD---IAFETWEIIFRNMNKEDEGEITKSlRRPETSYRQTGLAPGQEYEISLHIVKNN 789
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVT-PGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|..
gi 1598230890  790 TRGPGLKKVTTT 801
Cdd:cd00063     81 GESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 713-794 2.99e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.92  E-value: 2.99e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890   713 PAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRP--ETSYRQTGLAPGQEYEISLHIVknNT 790
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTpsSTSYTLTGLKPGTEYEFRVRAV--NG 79


                    ....
gi 1598230890   791 RGPG 794
Cdd:smart00060   80 AGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1709-1785 7.48e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.76  E-value: 7.48e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  1709 DGPSGLLIANITDSEALAMWQ-PAIATVDSYVISYTGERVPE----VTRTVSGNTVEYELHDLEPATEYILSIFAEKGQQ 1783
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEpPPDDGITGYIVGYRVEYREEgsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1598230890  1784 KS 1785
Cdd:smart00060   82 EG 83
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 408-435 1.39e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 46.52  E-value: 1.39e-06
                           10        20
                   ....*....|....*....|....*...
gi 1598230890  408 CPNGCSGHGRCVNGQCVCDEGYTGEDCS 435
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1530-1608 2.13e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 2.13e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  1530 PEVDNLLVSDATPDGFRLSWTA-DEGIFDSFVIRIRDTKKQSEPQEISLPSPERTR--DITGLREATEYEIELYGISRGR 1606
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPpPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTsyTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1598230890  1607 RS 1608
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1709-1794 3.27e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 47.11  E-value: 3.27e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1709 DGPSGLLIANITDSEALAMWQPA---IATVDSYVISYTGERVPEVTR--TVSGNTVEYELHDLEPATEYILSIFAEKGQQ 1783
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPeddGGPITGYVVEYREKGSGDWKEveVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 1598230890 1784 KS-STIATKFTT 1794
Cdd:cd00063     82 ESpPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1260-1336 9.12e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.95  E-value: 9.12e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1260 GGLSVTEVSWDGLTLNWT---TDDLAYKHFVVQVQEANNVEAAQNLTVPGSLRAVDIPGLKADTPYRVSIYGVIQGYRTP 1336
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTppeDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESP 84
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 190-217 9.19e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 44.21  E-value: 9.19e-06
                           10        20
                   ....*....|....*....|....*...
gi 1598230890  190 CPGNCNLRGQCLDGQCICDEGFTGEDCS 217
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 501-528 1.33e-05

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 43.83  E-value: 1.33e-05
                           10        20
                   ....*....|....*....|....*...
gi 1598230890  501 CPRDCSQRGRCVDGQCICEDGFTGPDCA 528
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 470-496 1.76e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 40.36  E-value: 1.76e-04
                           10        20
                   ....*....|....*....|....*..
gi 1598230890  470 CPNDCHQHGRCVNGMCICDDDYTGEDC 496
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 594-621 3.14e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 39.59  E-value: 3.14e-04
                           10        20
                   ....*....|....*....|....*...
gi 1598230890  594 CPNDCSNQGQCVSGRCICNEGYTGIDCS 621
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 439-466 6.31e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 38.82  E-value: 6.31e-04
                           10        20
                   ....*....|....*....|....*...
gi 1598230890  439 CPNDCHNRGLCVQGKCICEQGFKGFDCS 466
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 535-558 9.53e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.48  E-value: 9.53e-04
                           10        20
                   ....*....|....*....|....*.
gi 1598230890  535 DCHGHGRCVN--GQCICHEGFTGKDC 558
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1261-1329 1.03e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.91  E-value: 1.03e-03
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1598230890  1261 GLSVTEVSWDGLTLNWT-TDDLAYKHFVVQVQEANNVEAA--QNLTVPGSLRAVDIPGLKADTPYRVSIYGV 1329
Cdd:smart00060    6 NLRVTDVTSTSVTLSWEpPPDDGITGYIVGYRVEYREEGSewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 346-373 1.23e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 38.05  E-value: 1.23e-03
                           10        20
                   ....*....|....*....|....*...
gi 1598230890  346 CPNDCQGRGQCEEGQCVCNEGFAGADCS 373
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 380-403 1.36e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 37.71  E-value: 1.36e-03
                           10        20
                   ....*....|....*....|....*.
gi 1598230890  380 DCHHRGRC--LNGQCECDDGFTGADC 403
Cdd:pfam07974    1 ICSGRGTCvnQCGKCVCDSGYQGATC 26
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 252-280 3.77e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 36.89  E-value: 3.77e-03
                           10        20
                   ....*....|....*....|....*....
gi 1598230890  252 CPVPCSEEhGMCVDGRCVCKDGFAGEDCN 280
Cdd:pfam18720    2 CPLGCSSR-GVCVDGQCICDSEYSGDDCS 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 409-434 3.99e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 3.99e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1598230890  409 PNGCSGHGRCVNG----QCVCDEGYTGEDC 434
Cdd:cd00054      8 GNPCQNGGTCVNTvgsyRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 526-559 4.41e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 4.41e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1598230890  526 DCAElscPSDCHGHGRCVNG----QCICHEGFTGKDCK 559
Cdd:cd00054      4 ECAS---GNPCQNGGTCVNTvgsyRCSCPPGYTGRNCE 38
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 284-311 6.41e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 36.12  E-value: 6.41e-03
                           10        20
                   ....*....|....*....|....*...
gi 1598230890  284 CLNNCYNRGRCVENECVCDEGFTGEDCS 311
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 563-589 9.51e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 35.74  E-value: 9.51e-03
                           10        20
                   ....*....|....*....|....*..
gi 1598230890  563 CPSDCHGQGRCEDGQCICHEGFTGLDC 589
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
 
Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
1889-2098 1.97e-113

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 359.14  E-value: 1.97e-113
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1889 FPRDCSQAMLNGDTTSGLYTIYINGDKTQaLEVYCDMTSDGGGWIVFLRRKNGREDFYRNWKAYAAGFGD-RREEFWLGL 1967
Cdd:pfam00147    1 FGRDCSDVYNKGAKTSGLYTIRPDGATKP-FEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNlSPGEFWLGN 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1968 DNLSKITAQGQYELRVDLQDH-GESAYAVYDRFSVGDAKSRYKLKVEGYSGTAGD-------SMNYHNGRSFSTYDKDTD 2039
Cdd:pfam00147   80 DKIHLLTKQGPYVLRIDLEDWnGETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDND 159

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1598230890 2040 SAITNCALSYKGAFWYKNCHRVNLMGRY--GDNNHSQ-GVNWFHWKGHEYSIQFAEMKLRPS 2098
Cdd:pfam00147  160 SPDGNCALSYGGGWWYNNCHAANLNGVYyyGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 1889-2097 5.91e-110

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 348.88  E-value: 5.91e-110
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  1889 FPRDCSQAMLNGDTTSGLYTIYINGDkTQALEVYCDMTSDGGGWIVFLRRKNGREDFYRNWKAYAAGFGDRREEFWLGLD 1968
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDGS-SRPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  1969 NLSKITAQGQYELRVDLQD-HGESAYAVYDRFSVGDAKSRYKLKVEGYSGTAGD-SMNYHNGRSFSTYDKDTDSAITNCA 2046
Cdd:smart00186   80 NIHLLTSQGKYELRIDLEDwEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1598230890  2047 LSYKGAFWYKNCHRVNLMGRYG-DNNHSQGVNWFHWKGHEYSIQFAEMKLRP 2097
Cdd:smart00186  160 EEYGGGWWYNNCHAANLNGRYYpNNNYDNGINWATWKGSWYSLKFTEMKIRP 211
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 1888-2097 1.45e-109

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 347.69  E-value: 1.45e-109
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1888 PFPRDCSQAMLNGDTTSGLYTIYINGDKtQALEVYCDMTSDGGGWIVFLRRKNGREDFYRNWKAYAAGFGDRREEFWLGL 1967
Cdd:cd00087      1 PLPRDCSEVLQRGGRTSGVYTIQPPGSN-EPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1968 DNLSKITAQGQYELRVDLQD-HGESAYAVYDRFSVGDAKSRYKLKVEGYSGTAGDSMNYHNGRSFSTYDKDTDSAITNCA 2046
Cdd:cd00087     80 EKIHLLTSQGPYELRIDLEDwEGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGNCA 159

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1598230890 2047 LSYKGAFWYKNCHRVNLMGRYG----DNNHSQGVNWFHWKGHEYSIQFAEMKLRP 2097
Cdd:cd00087    160 ESYSGGWWYNSCHASNLNGRYYsgghRNEYDNGINWATWKGSTYSLKFTEMKIRP 214
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
861-1244 2.19e-22

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 104.31  E-value: 2.19e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  861 GNLRPDTEYEVSLISRRVDMASNPAKE----TFITGLDAPRNLRRVSQTDNSITLEWRNVKA-DIDSYRIKYAPISGGDH 935
Cdd:COG3401    197 GDIEPGTTYYYRVAATDTGGESAPSNEvsvtTPTTPPSAPTGLTATADTPGSVTLSWDPVTEsDATGYRVYRSNSGDGPF 276

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  936 AEIdvpksqqATTKTTL---TGLRPGTEYGIGVSAVKGDKE----SDPATINAATEI-DAPKDLRVSETTQDSLTFFWT- 1006
Cdd:COG3401    277 TKV-------ATVTTTSytdTGLTNGTTYYYRVTAVDAAGNesapSNVVSVTTDLTPpAAPSGLTATAVGSSSITLSWTa 349

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1007 TPLAKFDRYRLNYSLPTGQSME-VQLPKDATSHVLTDLEPGQEYTVLLIA--EKGRHKSKPARVKASTEEVPSLENLTVT 1083
Cdd:COG3401    350 SSDADVTGYNVYRSTSGGGTYTkIAETVTTTSYTDTGLTPGTTYYYKVTAvdAAGNESAPSEEVSATTASAASGESLTAS 429

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1084 EAGWDGLR-LNWTADDLAYEYFVIQVQEANNVETAHNFTVPGNLRAADIPGLKVATSYRVSIYGVARGYRTpvlSAETST 1162
Cdd:COG3401    430 VDAVPLTDvAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGS---GASSVT 506

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1163 GTTPNLGEVTVAEVGWdalTLNWTAPEGAYKNFFIQVLEADTTQTVQNLTVPGGLRSVDLPGLKAATRYYITLRGVTQDF 1242
Cdd:COG3401    507 NSVSVIGASAAAAVGG---APDGTPNVTGASPVTVGASTGDVLITDLVSLTTSASSSVSGAGLGSGNLYLITTLGGSLLT 583


                   ..
gi 1598230890 1243 GT 1244
Cdd:COG3401    584 TT 585
fn3 pfam00041
Fibronectin type III domain;
894-976 6.00e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 71.68  E-value: 6.00e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  894 DAPRNLRRVSQTDNSITLEW---RNVKADIDSYRIKYAPISGGDHA-EIDVPKSqqaTTKTTLTGLRPGTEYGIGVSAVK 969
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWtppPDGNGPITGYEVEYRPKNSGEPWnEITVPGT---TTSVTLTGLKPGTEYEVRVQAVN 77


                   ....*..
gi 1598230890  970 GDKESDP 976
Cdd:pfam00041   78 GGGEGPP 84
fn3 pfam00041
Fibronectin type III domain;
1797-1869 2.69e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 70.14  E-value: 2.69e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1598230890 1797 DSPREFTATEVQSETALLTWRPPR---ASVTGYLLVYESVDGT--VKEVIVGPDTTSYSLADLSPSTHYSARIQALSG 1869
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 624-710 8.37e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.06  E-value: 8.37e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  624 SPPKDLIVTEVTEETVNLAW----DNEMRVTEYLIMYTPTHADGLEMQFRVPGDQTSTTIRELEPGVEYFIRVFAILENK 699
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWtppeDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|.
gi 1598230890  700 RSIPVSARVAT 710
Cdd:cd00063     82 ESPPSESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 894-978 2.94e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.14  E-value: 2.94e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  894 DAPRNLRRVSQTDNSITLEWRNVKAD---IDSYRIKYAPISGGDHAEIDVPKSQqaTTKTTLTGLRPGTEYGIGVSAVKG 970
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGS--ETSYTLTGLKPGTEYEFRVRAVNG 79


                   ....*...
gi 1598230890  971 DKESDPAT 978
Cdd:cd00063     80 GGESPPSE 87
fn3 pfam00041
Fibronectin type III domain;
1530-1610 7.33e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.90  E-value: 7.33e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1530 PEVDNLLVSDATPDGFRLSWTADE---GIFDSFVIRIRDTKKQSEPQEISLPSPERTRDITGLREATEYEIELYGISRGR 1606
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1598230890 1607 RSQP 1610
Cdd:pfam00041   81 EGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
638-997 1.05e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 73.50  E-value: 1.05e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  638 TVNLAWDNEMRVTEYLIMYTPTHADGLEMQFRVPGDQTSTTIRELEPGVEYFIRVFAILENKRSIP---VSARVATYLP- 713
Cdd:COG3401    155 ASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPsneVSVTTPTTPPs 234

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  714 APEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGE-ITKSlrrPETSYRQTGLAPGQEYeislhivknntrg 792
Cdd:COG3401    235 APTGLTATADTPGSVTLSWDPVTESDATGYRVYRSNSGDGPFTkVATV---TTTSYTDTGLTNGTTY------------- 298

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  793 pglkkvtttrldapshievkdvtdttalitwfkplaeidsielSYGIKDVpgdrttidlthednqysignlrpDTEYEVS 872
Cdd:COG3401    299 -------------------------------------------YYRVTAV-----------------------DAAGNES 312

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  873 lisrrvdMASNPAK-ETFITGLDAPRNLRRVSQTDNSITLEWRNVK-ADIDSYRIKYAPISGGDHAEIDVPKSqqaTTKT 950
Cdd:COG3401    313 -------APSNVVSvTTDLTPPAAPSGLTATAVGSSSITLSWTASSdADVTGYNVYRSTSGGGTYTKIAETVT---TTSY 382

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*...
gi 1598230890  951 TLTGLRPGTEYGIGVSAV-KGDKESDPATINAATEIDAPKDLRVSETT 997
Cdd:COG3401    383 TDTGLTPGTTYYYKVTAVdAAGNESAPSEEVSATTASAASGESLTASV 430
fn3 pfam00041
Fibronectin type III domain;
986-1064 1.92e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.74  E-value: 1.92e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  986 DAPKDLRVSETTQDSLTFFWTTPL---AKFDRYRLNYSLPTGQSM--EVQLPKDATSHVLTDLEPGQEYTVLLIAEKGRH 1060
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPwnEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1598230890 1061 KSKP 1064
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
624-695 2.23e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 2.23e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1598230890  624 SPPKDLIVTEVTEETVNLAW----DNEMRVTEYLIMYTPTHADGLEMQFRVPGDQTSTTIRELEPGVEYFIRVFAI 695
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWtpppDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
fn3 pfam00041
Fibronectin type III domain;
1257-1336 2.76e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 2.76e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1257 PQLGGLSVTEVSWDGLTLNWT---TDDLAYKHFVVQVQEANNVEAAQNLTVPGSLRAVDIPGLKADTPYRVSIYGVIQGY 1333
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ...
gi 1598230890 1334 RTP 1336
Cdd:pfam00041   81 EGP 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
624-779 3.23e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 71.57  E-value: 3.23e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  624 SPPKDLIVTEVTEETVNLAWD--NEMRVTEYLImYTPTHADGlemQFRVPGDQTSTTI--RELEPGVEYFIRVFAILENK 699
Cdd:COG3401    234 SAPTGLTATADTPGSVTLSWDpvTESDATGYRV-YRSNSGDG---PFTKVATVTTTSYtdTGLTNGTTYYYRVTAVDAAG 309

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  700 R----SIPVSARVATYLP-APEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDE-GEITKSLRrpETSYRQTGL 773
Cdd:COG3401    310 NesapSNVVSVTTDLTPPaAPSGLTATAVGSSSITLSWTASSDADVTGYNVYRSTSGGGTyTKIAETVT--TTSYTDTGL 387


                   ....*.
gi 1598230890  774 APGQEY 779
Cdd:COG3401    388 TPGTTY 393
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1797-1869 4.46e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.79  E-value: 4.46e-12
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1598230890  1797 DSPREFTATEVQSETALLTWRPPRAS-----VTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYSARIQALSG 1869
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1620-1706 5.58e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 63.67  E-value: 5.58e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1620 GSPKEIMFSDITENAATVSWRAPT---AQVESFRITYVPMTGGAPSMVTV-DGTDTETRLVKLTPGVEYRVSVIAMKGFE 1695
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVtPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|.
gi 1598230890 1696 ESDPVSGTLIT 1706
Cdd:cd00063     82 ESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
713-793 7.84e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.82  E-value: 7.84e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  713 PAPEGLKFKSIKETSVEVEWDP---LDIAFETWEIIFRNMNKEDEgEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNN 789
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEP-WNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....
gi 1598230890  790 TRGP 793
Cdd:pfam00041   80 GEGP 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1627-1866 8.22e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 70.42  E-value: 8.22e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1627 FSDITENAATVSWRAPTAQVESFRITYVPMTGGAPS-MVTVDGTDTETRLVKLTPGVEYRVSVIAMKGFEESDPVSG--- 1702
Cdd:COG3401    147 LYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATtSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEvsv 226

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1703 -TLITALDGPSGLLIANITDSEALAMWQPAIAT-VDSYVISYTGERVPEVTRTVSGNTVEYELHDLEPATEYILSIFAEK 1780
Cdd:COG3401    227 tTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVD 306

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1781 GQ----QKSSTI-ATKFTTDLDSPREFTATEVQSETALLTWRPPRAS-VTGYLlVY--ESVDGTVKEVIVGPDTTSYSLA 1852
Cdd:COG3401    307 AAgnesAPSNVVsVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDAdVTGYN-VYrsTSGGGTYTKIAETVTTTSYTDT 385

                          250
                   ....*....|....
gi 1598230890 1853 DLSPSTHYSARIQA 1866
Cdd:COG3401    386 GLTPGTTYYYKVTA 399
fn3 pfam00041
Fibronectin type III domain;
1169-1248 1.02e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.82  E-value: 1.02e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1169 GEVTVAEVGWDALTLNWTAPE---GAYKNFFIQVLEADTTQTVQNLTVPGGLRSVDLPGLKAATRYYITLRGVTQDfGTA 1245
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG-GEG 82


                   ...
gi 1598230890 1246 PLS 1248
Cdd:pfam00041   83 PPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 986-1065 1.20e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.90  E-value: 1.20e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  986 DAPKDLRVSETTQDSLTFFWTTPL---AKFDRYRLNYS-LPTGQSMEVQL-PKDATSHVLTDLEPGQEYTVLLIAEKGRH 1060
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYReKGSGDWKEVEVtPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                   ....*
gi 1598230890 1061 KSKPA 1065
Cdd:cd00063     82 ESPPS 86
fn3 pfam00041
Fibronectin type III domain;
1620-1699 2.18e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.66  E-value: 2.18e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1620 GSPKEIMFSDITENAATVSWRAPT---AQVESFRITYVPM-TGGAPSMVTVDGTDTETRLVKLTPGVEYRVSVIAMKGFE 1695
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKnSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1598230890 1696 ESDP 1699
Cdd:pfam00041   81 EGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1322-1888 2.32e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 68.88  E-value: 2.32e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1322 YRVSIYGVIQGYRTPMLSTDVSTAREPEIGNLNVSDVTPKSFNLSWTATDGIFDMFTIEI-IDSNRLLQTAEHNISGAER 1400
Cdd:COG3401     24 NALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAvAAAPPTATGLTTLTGSGSV 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1401 TAHISGLPPSTDFIVYLSGIAPSIRTKTISTTATTEALPLLENLTISDTNPYGFTVSWTASENAFDSFLVTVVDSGKLLD 1480
Cdd:COG3401    104 GGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATT 183

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1481 pqEFTLSGTQRKLELRGLITGIGYEVLVSGFTQGHQTKP---LRAETITEAEPEVDNLLVSDATPDGFRLSWTA--DEGI 1555
Cdd:COG3401    184 --SLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPsneVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPvtESDA 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1556 fDSFVIRiRDTKKQSEPQEISLPSPERTRDiTGLREATEYEielYGIS----RGRRSQPVSAIATTAMGS----PKEIMF 1627
Cdd:COG3401    262 -TGYRVY-RSNSGDGPFTKVATVTTTSYTD-TGLTNGTTYY---YRVTavdaAGNESAPSNVVSVTTDLTppaaPSGLTA 335

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1628 SDITENAATVSWRAPT-AQVESFRITYVPMTGGAPSMVTVDGTDTETRLVKLTPGVEYRVSVIAM----KGFEESDPVSG 1702
Cdd:COG3401    336 TAVGSSSITLSWTASSdADVTGYNVYRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVdaagNESAPSEEVSA 415

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1703 TLITALDGPSGLLIANITDSEALAMWQPAIATVDSYVISYTGERVPEVTRTVSGNTVEYELHDLEPATEYiLSIFAEKGQ 1782
Cdd:COG3401    416 TTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTT-TANLSVTTG 494

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1783 QKSSTIATKFTTDLDSPREFTATEVQSETalLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYSA 1862
Cdd:COG3401    495 SLVGGSGASSVTNSVSVIGASAAAAVGGA--PDGTPNVTGASPVTVGASTGDVLITDLVSLTTSASSSVSGAGLGSGNLY 572

                          570       580
                   ....*....|....*....|....*.
gi 1598230890 1863 RIQALSGSLRSKLIQTIFTTIGLLYP 1888
Cdd:COG3401    573 LITTLGGSLLTTTSTNTNDVAGVHGG 598
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1797-1882 5.05e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.97  E-value: 5.05e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1797 DSPREFTATEVQSETALLTWRPPR---ASVTGYLLVYESVD-GTVKEVIVGP-DTTSYSLADLSPSTHYSARIQALSGSL 1871
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGsGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 1598230890 1872 RSKLIQTI-FTT 1882
Cdd:cd00063     82 ESPPSESVtVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 624-701 1.05e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 59.55  E-value: 1.05e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890   624 SPPKDLIVTEVTEETVNLAWD--NEMRVTEYLIMYTPTH--ADGLEMQFRVPGDQTSTTIRELEPGVEYFIRVFAILENK 699
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEppPDDGITGYIVGYRVEYreEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1598230890   700 RS 701
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
1075-1154 1.11e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 59.74  E-value: 1.11e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1075 PSLENLTVTEAGWDGLRLNWTADDL---AYEYFVIQVQEANNVETAHNFTVPGNLRAADIPGLKVATSYRVSIYGVARGY 1151
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ...
gi 1598230890 1152 RTP 1154
Cdd:pfam00041   81 EGP 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 986-1062 1.36e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 59.55  E-value: 1.36e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890   986 DAPKDLRVSETTQDSLTFFWTTP-----LAKFDRYRLNYSLPTGQSMEVQLPKDATSHVLTDLEPGQEYTVLLIAEKGRH 1060
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1598230890  1061 KS 1062
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 894-974 3.89e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.01  E-value: 3.89e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890   894 DAPRNLRRVSQTDNSITLEWRNVKAD-IDSYRIKYAPISGGDHAEIDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKGDK 972
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1598230890   973 ES 974
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 804-891 7.37e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.51  E-value: 7.37e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  804 DAPSHIEVKDVTDTTALITWFKPL---AEIDSIELSYGIKDVPGDRTTIDLTHEDNQYSIGNLRPDTEYEVSLISRRVDM 880
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|.
gi 1598230890  881 ASNPAKETFIT 891
Cdd:cd00063     82 ESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
1442-1514 9.08e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.04  E-value: 9.08e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1598230890 1442 ENLTISDTNPYGFTVSWTASEN---AFDSFLVTVVDSGKLLDPQEFTLSGTQRKLELRGLITGIGYEVLVSGFTQG 1514
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
1711-1785 1.62e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 56.27  E-value: 1.62e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1711 PSGLLIANITDSEALAMWQPA---IATVDSYVISY--TGERVPEVTRTVSGNTVEYELHDLEPATEYILSIFAEKGQQKS 1785
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYrpKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1620-1697 2.74e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.70  E-value: 2.74e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  1620 GSPKEIMFSDITENAATVSWRAPT-AQVESFRITYVPMTGGAPS---MVTVDGTDTETRLVKLTPGVEYRVSVIAMKGFE 1695
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPdDGITGYIVGYRVEYREEGSewkEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1598230890  1696 ES 1697
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1532-1617 3.37e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.97  E-value: 3.37e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1532 VDNLLVSDATPDGFRLSWTA---DEGIFDSFVIRIRDtKKQSEPQEISLPSPERTR-DITGLREATEYEIELYGISRGRR 1607
Cdd:cd00063      4 PTNLRVTDVTSTSVTLSWTPpedDGGPITGYVVEYRE-KGSGDWKEVEVTPGSETSyTLTGLKPGTEYEFRVRAVNGGGE 82

                           90
                   ....*....|
gi 1598230890 1608 SQPVSAIATT 1617
Cdd:cd00063     83 SPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
1348-1417 4.59e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 4.59e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1598230890 1348 PEIGNLNVSDVTPKSFNLSWTA---TDGIFDMFTIEIIDSNRLLQTAEHNISGAERTAHISGLPPSTDFIVYL 1417
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRV 73
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 804-876 5.93e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.93  E-value: 5.93e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1598230890   804 DAPSHIEVKDVTDTTALITWFKPLAE-IDSIELSYGIKDVPGDR--TTIDLTHEDNQYSIGNLRPDTEYEVSLISR 876
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
fn3 pfam00041
Fibronectin type III domain;
804-884 8.17e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.34  E-value: 8.17e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  804 DAPSHIEVKDVTDTTALITWFKPL---AEIDSIELSYGIKDVPGDRTTIDLTHEDNQYSIGNLRPDTEYEVSLISRRVDM 880
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1598230890  881 ASNP 884
Cdd:pfam00041   81 EGPP 84
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 1899-1932 1.37e-08

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 52.56  E-value: 1.37e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1598230890 1899 NGDTTSGLYTIYINGD-KTQALEVYCDMTSDGGGW 1932
Cdd:NF040941     9 GPSAPSGVYWIDPDGMgGLAPFQVYCDMTTDGGGW 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 713-801 2.59e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.57  E-value: 2.59e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  713 PAPEGLKFKSIKETSVEVEWDPLD---IAFETWEIIFRNMNKEDEGEITKSlRRPETSYRQTGLAPGQEYEISLHIVKNN 789
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVT-PGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|..
gi 1598230890  790 TRGPGLKKVTTT 801
Cdd:cd00063     81 GESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 713-794 2.99e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.92  E-value: 2.99e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890   713 PAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRP--ETSYRQTGLAPGQEYEISLHIVknNT 790
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTpsSTSYTLTGLKPGTEYEFRVRAV--NG 79


                    ....
gi 1598230890   791 RGPG 794
Cdd:smart00060   80 AGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1709-1785 7.48e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.76  E-value: 7.48e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  1709 DGPSGLLIANITDSEALAMWQ-PAIATVDSYVISYTGERVPE----VTRTVSGNTVEYELHDLEPATEYILSIFAEKGQQ 1783
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEpPPDDGITGYIVGYRVEYREEgsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1598230890  1784 KS 1785
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1171-1253 1.08e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 48.65  E-value: 1.08e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1171 VTVAEVGWDALTLNWTAPE---GAYKNFFIQVLEADTTQTVQNLTVPGGLRSVDLPGLKAATRYYITLRGVTQD-FGTAP 1246
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGgESPPS 86


                   ....*..
gi 1598230890 1247 LSVEVLT 1253
Cdd:cd00063     87 ESVTVTT 93
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 408-435 1.39e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 46.52  E-value: 1.39e-06
                           10        20
                   ....*....|....*....|....*...
gi 1598230890  408 CPNGCSGHGRCVNGQCVCDEGYTGEDCS 435
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1530-1608 2.13e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 2.13e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  1530 PEVDNLLVSDATPDGFRLSWTA-DEGIFDSFVIRIRDTKKQSEPQEISLPSPERTR--DITGLREATEYEIELYGISRGR 1606
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPpPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTsyTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1598230890  1607 RS 1608
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1709-1794 3.27e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 47.11  E-value: 3.27e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1709 DGPSGLLIANITDSEALAMWQPA---IATVDSYVISYTGERVPEVTR--TVSGNTVEYELHDLEPATEYILSIFAEKGQQ 1783
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPeddGGPITGYVVEYREKGSGDWKEveVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 1598230890 1784 KS-STIATKFTT 1794
Cdd:cd00063     82 ESpPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1171-1240 5.56e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.45  E-value: 5.56e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1598230890  1171 VTVAEVGWDALTLNWTAPEGAYKNFFI---QVLEADTTQTVQNLTVPGGLRSVDLPGLKAATRYYITLRGVTQ 1240
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPDDGITGYIvgyRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1128-1372 7.98e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 51.16  E-value: 7.98e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1128 AADIPGLKVATSYRVSIYGVARGYRTPVLSAeTSTGTTPNLGEVTVAEVGWDALTLNWTAPEGAYKNFFIQVLEADTTQT 1207
Cdd:COG3401    104 GGATNTGLTSSDEVPSPAVGTATTATAVAGG-AATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVAT 182

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1208 VQNLTVPGGLrSVDLPGLKAATRYYITLRgVTQDFGTAPLS--VEVLTEDLPQL--GGLSVTEVSWDGLTLNWTT-DDLA 1282
Cdd:COG3401    183 TSLTVTSTTL-VDGGGDIEPGTTYYYRVA-ATDTGGESAPSneVSVTTPTTPPSapTGLTATADTPGSVTLSWDPvTESD 260

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1283 YKHFVVQVQEANNVEAAQnLTVPGSLRAVDiPGLKADTPYRVSIYGVIQGYRTPMLSTDVSTAREPE----IGNLNVSDV 1358
Cdd:COG3401    261 ATGYRVYRSNSGDGPFTK-VATVTTTSYTD-TGLTNGTTYYYRVTAVDAAGNESAPSNVVSVTTDLTppaaPSGLTATAV 338

                          250
                   ....*....|....
gi 1598230890 1359 TPKSFNLSWTATDG 1372
Cdd:COG3401    339 GSSSITLSWTASSD 352
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1260-1336 9.12e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.95  E-value: 9.12e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1260 GGLSVTEVSWDGLTLNWT---TDDLAYKHFVVQVQEANNVEAAQNLTVPGSLRAVDIPGLKADTPYRVSIYGVIQGYRTP 1336
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTppeDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESP 84
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 190-217 9.19e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 44.21  E-value: 9.19e-06
                           10        20
                   ....*....|....*....|....*...
gi 1598230890  190 CPGNCNLRGQCLDGQCICDEGFTGEDCS 217
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
798-1239 9.93e-06

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 51.10  E-value: 9.93e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  798 VTTTRLDAPSHIEVKDVTDTTALITWFKPLAEID-SIELSYGIKDVPGDRTTIDLTHEDNQYSIGNlrpdteYEVSLISR 876
Cdd:COG4733    533 PVNVTTSESLSVVAQGTAVTTLTVSWDAPAGAVAyEVEWRRDDGNWVSVPRTSGTSFEVPGIYAGD------YEVRVRAI 606

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  877 -RVDMASNPA--KETFITGLD----APRNLRrVSQTDNSITLEWRN-VKADIDSYRIKYAPisGGDHAEIDVPKSQQATT 948
Cdd:COG4733    607 nALGVSSAWAasSETTVTGKTapppAPTGLT-ATGGLGGITLSWSFpVDADTLRTEIRYST--TGDWASATVAQALYPGN 683

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  949 KTTLTGLRPGTEYGIGVSAV-KGDKESdPATINAATEIDAPKDLrvsettqdsltffwttplakfdryrlnySLPTGQSM 1027
Cdd:COG4733    684 TYTLAGLKAGQTYYYRARAVdRSGNVS-AWWVSGQASADAAGIL----------------------------DAITGQIL 734

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1028 EVQLPK--DATSHVLTDLEPGQEYTVLLIAEKGRHKSKPARVKASTEEVPSLENLTVTEAGWDGLRLNWTADdlAYEYFV 1105
Cdd:COG4733    735 ETELGQelDAIIQNATVAEVVAATVTDVTAQIDTAVLFAGVATAAAIGAEARVAATVAESATAAAATGTAAD--AAGDAS 812

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1106 IQVQEANNVETAHNFTVPGNLRAADIPGLKVATSYRVSI-----YGVARGYRTPVLSAETSTGTTPNLGEVTVAEVGWDA 1180
Cdd:COG4733    813 GGVTAGTSGTTGAGDTAASTTRVAAAVVLAGVVVYGDAIiesgnTGDIVATGDIASAAAGAVATTVSGTTAADVSAVADS 892

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1598230890 1181 LTLNWTAPEGAYKNFFIQVLEADTTQTVQNLTVPGGLRSVDLPGLKAATRYYITLRGVT 1239
Cdd:COG4733    893 TAASLTAIVIAATTIIDAIGDGTTREPAGDIGASGGAQGFAVTIVGSFDGAGAVATVDA 951
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 501-528 1.33e-05

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 43.83  E-value: 1.33e-05
                           10        20
                   ....*....|....*....|....*...
gi 1598230890  501 CPRDCSQRGRCVDGQCICEDGFTGPDCA 528
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 470-496 1.76e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 40.36  E-value: 1.76e-04
                           10        20
                   ....*....|....*....|....*..
gi 1598230890  470 CPNDCHQHGRCVNGMCICDDDYTGEDC 496
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 594-621 3.14e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 39.59  E-value: 3.14e-04
                           10        20
                   ....*....|....*....|....*...
gi 1598230890  594 CPNDCSNQGQCVSGRCICNEGYTGIDCS 621
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1078-1165 3.83e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 41.33  E-value: 3.83e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1078 ENLTVTEAGWDGLRLNWTA---DDLAYEYFVIQVQEANNVETAHNFTVPGNLRAADIPGLKVATSYRVSIYGVARGYRTP 1154
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPpedDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESP 84

                           90
                   ....*....|.
gi 1598230890 1155 vlSAETSTGTT 1165
Cdd:cd00063     85 --PSESVTVTT 93
fn3_2 pfam16893
Fibronectin type III domain; This fibronectin type III domain is found in fungal chitin ...
 713-783 4.67e-04

Fibronectin type III domain; This fibronectin type III domain is found in fungal chitin biosynthesis protein CHS5 where, together with the neighbouring BRCT domain (pfam00533), it binds to the Arf1 GTPase.


Pssm-ID: 435634  Cd Length: 89  Bit Score: 41.03  E-value: 4.67e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1598230890  713 PAPEGLKFKSIKETSVEVEWDPLDIAFETWE--IIFRNMNKedEGEITKSLRRpeTSYRQTGLAPGQEYEISL 783
Cdd:pfam16893    3 PKAPVLKVRNVTQTSVVLEWDPLELGTAKLKslDLYRNGQR--LGVIPNPLTN--TSTKLSGLSVDTEYTFQL 71
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 412-434 5.04e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 39.25  E-value: 5.04e-04
                           10        20
                   ....*....|....*....|....*
gi 1598230890  412 CSGHGRCVN--GQCVCDEGYTGEDC 434
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
COG1470 COG1470
Uncharacterized membrane protein [Function unknown];
940-1362 5.33e-04

Uncharacterized membrane protein [Function unknown];


Pssm-ID: 441079 [Multi-domain]  Cd Length: 475  Bit Score: 44.85  E-value: 5.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  940 VPKSQQATTKTTLTGLRPGTEYGIGVSAVKGDKESDPATINAATEIDAPKDLRV---SETTQDSLTFFWTTPLAKFDRYR 1016
Cdd:COG1470      6 LVASSTVAAGALAALLDLTTPLVGSTVALTSTASALSGERTTLAALAATGGLVTatpVSPTSATLTLSVEVPSNATVGTY 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1017 LNYSLpTGQSMEVQLPKDATSHVLTdlePGQEYTVlliaekgrhkskPARVKaSTEEVPSLENLTVTEA--GWDGLRLNW 1094
Cdd:COG1470     86 LPITV-TVAPYGLTLSVESPSLEVA---PGETVTY------------TVTLT-NTGDEPDTVSLSAEGLpeGWTVTFTPD 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1095 TADDLA---YEYFVIQVQEANNVET-AHNFTVpgNLRAADIPG-------LKVATSYRVSI------YGVARGYRTPVLS 1157
Cdd:COG1470    149 TSVSLApgeSKTVTLEVTPPANAEPgTYPVTV--TATSGEDSSsasltltLTVTGSYELELsstptgRTVTPGESATFTV 226

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1158 AETSTGTTPNLGEVTVAEVGWDALTLNWTAPEgayknffIQVLEADTTQTVQ-NLTVPGGLrsvdlpglkAATRYYITLR 1236
Cdd:COG1470    227 TVTNTGNGADLTNVTLSASAPSGWTVSFEPET-------IPSLAPGESATVTlTVTVPADA---------TAGDYTVTVT 290

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1237 GVTQDFGTAPLSVEVLTEDLPQLGGLSVTEVS---WDGLTLNWTTDDLAYKHFVVQVQEANNVEAAQNLTVPGSLRAVDI 1313
Cdd:COG1470    291 ATSDETASATLRLTVETSSLWGWIGYLIRKYGglgATGSLLVASVSLVVGAVVGTLTTPLLLTGFAGNGLLSAATAPLLL 370

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1314 PGLKA-DTPYRVSIYGVIQGYRTPMLSTDVSTAREPEIGNLNVSDVTPKS 1362
Cdd:COG1470    371 LLGLTlSLLSDVLVFTVGSAGVSAAAATAETSALTALGVGATGAVGSGSA 420
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1442-1526 5.72e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 40.94  E-value: 5.72e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1442 ENLTISDTNPYGFTVSWTASEN---AFDSFLVTVVDSGKLlDPQEF-TLSGTQRKLELRGLITGIGYEVLVSGFTQGHQT 1517
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEDdggPITGYVVEYREKGSG-DWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGES 83


                   ....*....
gi 1598230890 1518 KPLRAETIT 1526
Cdd:cd00063     84 PPSESVTVT 92
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 439-466 6.31e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 38.82  E-value: 6.31e-04
                           10        20
                   ....*....|....*....|....*...
gi 1598230890  439 CPNDCHNRGLCVQGKCICEQGFKGFDCS 466
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 535-558 9.53e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.48  E-value: 9.53e-04
                           10        20
                   ....*....|....*....|....*.
gi 1598230890  535 DCHGHGRCVN--GQCICHEGFTGKDC 558
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1261-1329 1.03e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.91  E-value: 1.03e-03
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1598230890  1261 GLSVTEVSWDGLTLNWT-TDDLAYKHFVVQVQEANNVEAA--QNLTVPGSLRAVDIPGLKADTPYRVSIYGV 1329
Cdd:smart00060    6 NLRVTDVTSTSVTLSWEpPPDDGITGYIVGYRVEYREEGSewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 346-373 1.23e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 38.05  E-value: 1.23e-03
                           10        20
                   ....*....|....*....|....*...
gi 1598230890  346 CPNDCQGRGQCEEGQCVCNEGFAGADCS 373
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 380-403 1.36e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 37.71  E-value: 1.36e-03
                           10        20
                   ....*....|....*....|....*.
gi 1598230890  380 DCHHRGRC--LNGQCECDDGFTGADC 403
Cdd:pfam07974    1 ICSGRGTCvnQCGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 349-372 1.97e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 37.33  E-value: 1.97e-03
                           10        20
                   ....*....|....*....|....*.
gi 1598230890  349 DCQGRGQCE--EGQCVCNEGFAGADC 372
Cdd:pfam07974    1 ICSGRGTCVnqCGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 504-527 1.99e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 37.33  E-value: 1.99e-03
                           10        20
                   ....*....|....*....|....*.
gi 1598230890  504 DCSQRGRCVD--GQCICEDGFTGPDC 527
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 377-403 2.05e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 37.66  E-value: 2.05e-03
                           10        20
                   ....*....|....*....|....*..
gi 1598230890  377 CPADCHHRGRCLNGQCECDDGFTGADC 403
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 532-558 3.45e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 36.89  E-value: 3.45e-03
                           10        20
                   ....*....|....*....|....*..
gi 1598230890  532 CPSDCHGHGRCVNGQCICHEGFTGKDC 558
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 252-280 3.77e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 36.89  E-value: 3.77e-03
                           10        20
                   ....*....|....*....|....*....
gi 1598230890  252 CPVPCSEEhGMCVDGRCVCKDGFAGEDCN 280
Cdd:pfam18720    2 CPLGCSSR-GVCVDGQCICDSEYSGDDCS 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 409-434 3.99e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 3.99e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1598230890  409 PNGCSGHGRCVNG----QCVCDEGYTGEDC 434
Cdd:cd00054      8 GNPCQNGGTCVNTvgsyRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 526-559 4.41e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 4.41e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1598230890  526 DCAElscPSDCHGHGRCVNG----QCICHEGFTGKDCK 559
Cdd:cd00054      4 ECAS---GNPCQNGGTCVNTvgsyRCSCPPGYTGRNCE 38
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 597-620 4.63e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 36.56  E-value: 4.63e-03
                           10        20
                   ....*....|....*....|....*.
gi 1598230890  597 DCSNQGQCVS--GRCICNEGYTGIDC 620
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 284-311 6.41e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 36.12  E-value: 6.41e-03
                           10        20
                   ....*....|....*....|....*...
gi 1598230890  284 CLNNCYNRGRCVENECVCDEGFTGEDCS 311
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1351-1415 6.63e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.86  E-value: 6.63e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1598230890 1351 GNLNVSDVTPKSFNLSWTA---TDGIFDMFTIEIIDSNRLLQTAEHNISGAERTAHISGLPPSTDFIV 1415
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPpedDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEF 72
COG3979 COG3979
Chitodextrinase [Carbohydrate transport and metabolism];
895-1234 7.65e-03

Chitodextrinase [Carbohydrate transport and metabolism];


Pssm-ID: 443178 [Multi-domain]  Cd Length: 369  Bit Score: 40.91  E-value: 7.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  895 APRNLRRVSQTDNSITLEWRnvkADIDSYRIKYAPISGGDhaeiDVPKSQQATTKTTLTGLRPGTEYGIGVSAV-KGDKE 973
Cdd:COG3979      5 APTGLTASNVTSSSVSLSWD---ASTDNVGVTGYDVYRGG----DQVATVTGLTAWTVTGLTPGTEYTFTVGACdAAGNV 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890  974 SDPATINAATEIDAPKDLRVSETTQDSLTFFWTTPLAKFDRYRLNYSLPTGQSMEVQLPKDATSHVLTDLEPGQEYTVLL 1053
Cdd:COG3979     78 SAASGTSTAMFGGSSTTLGSAEGVADTSGNLAASGAFFGVTTPPTPSSTLVVDGTTTVNAAATANGGTGGSGGTTTIITT 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1054 IAEKGRHKSKPARVKASTEEVPSLENLTVTEAGWDGLRLNWTADDLAYEYFVIQVQEANNVETAHNFTVPGNLRAADIPG 1133
Cdd:COG3979    158 GVEGGGGSKTAQSLNAITAAGTAALNGGVVGGADEVLTCSAVKDDGSGGAGAGNTYWALNTLGVSDTPSGTTATGGTVGI 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1598230890 1134 LKVATSYRVSIYGVARGYRTPVLS-AETSTGTTPNLGEVTVAEVGWDALTLNWTAPEGAYKNFFIQVLEADTTQTVQNLT 1212
Cdd:COG3979    238 TSAYGAGVSGNAAVNVNAGFVVGNvGGAAGNTGTTSGTATSDAATNDVGDAAVTGLNDGAANGPTGGYGATGTTVAGAAG 317

                          330       340
                   ....*....|....*....|..
gi 1598230890 1213 VPGGLRSVDLPGLKAATRYYIT 1234
Cdd:COG3979    318 VGGTKSGTGALGLSGAGGAGAA 339
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 563-589 9.51e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 35.74  E-value: 9.51e-03
                           10        20
                   ....*....|....*....|....*..
gi 1598230890  563 CPSDCHGQGRCEDGQCICHEGFTGLDC 589
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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