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Conserved domains on  [gi|1587062636|ref|NP_001355851|]
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paired box protein Pax-6 isoform l [Homo sapiens]

Protein Classification

homeobox protein( domain architecture ID 11021495)

homeobox protein with a paired box domain similar to mammalian Pax6, a transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas, and Drosophila gooseberry-neuro, which is involved in defining the polarity of embryonic segments

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
159-214 5.38e-28

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 104.12  E-value: 5.38e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1587062636 159 RNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRR 214
Cdd:pfam00046   2 RKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HTH_ARSR super family cl46857
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 4-70 3.07e-26

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


The actual alignment was detected with superfamily member smart00351:

Pssm-ID: 481197 [Multi-domain]  Cd Length: 125  Bit Score: 101.63  E-value: 3.07e-26
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1587062636    4 SHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQthadakvqvldnqnVSNGCVSSI 70
Cdd:smart00351   1 GHGGVNQLGGVFVNGRPLPDEERQRIVELAQNGVRPCDISRQLC--------------VSHGCVSKI 53
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
159-214 5.38e-28

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 104.12  E-value: 5.38e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1587062636 159 RNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRR 214
Cdd:pfam00046   2 RKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
PAX smart00351
Paired Box domain;
4-70 3.07e-26

Paired Box domain;


Pssm-ID: 128645 [Multi-domain]  Cd Length: 125  Bit Score: 101.63  E-value: 3.07e-26
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1587062636    4 SHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQthadakvqvldnqnVSNGCVSSI 70
Cdd:smart00351   1 GHGGVNQLGGVFVNGRPLPDEERQRIVELAQNGVRPCDISRQLC--------------VSHGCVSKI 53
PAX cd00131
Paired Box domain
 5-70 2.23e-25

Paired Box domain


Pssm-ID: 238076  Cd Length: 128  Bit Score: 99.42  E-value: 2.23e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1587062636   5 HSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQthadakvqvldnqnVSNGCVSSI 70
Cdd:cd00131     2 QGGVNQLGGVFVNGRPLPDSIRQRIVELAQSGIRPCDISRQLR--------------VSHGCVSKI 53
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 158-213 2.33e-24

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 94.24  E-value: 2.33e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1587062636  158 QRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWR 213
Cdd:smart00389   2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
PAX pfam00292
'Paired box' domain;
4-70 2.62e-24

'Paired box' domain;


Pssm-ID: 366005  Cd Length: 125  Bit Score: 96.48  E-value: 2.62e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1587062636   4 SHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQthadakvqvldnqnVSNGCVSSI 70
Cdd:pfam00292   1 GHGGVNQLGGVFVNGRPLPDHIRQKIVELAHSGVRPCDISRQLR--------------VSHGCVSKI 53
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 159-216 5.79e-24

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 93.46  E-value: 5.79e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1587062636 159 RNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREE 216
Cdd:cd00086     2 RKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
132-235 5.43e-12

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 63.22  E-value: 5.43e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1587062636 132 ENTNSISSNGEDSDEAqmrlqlKRKlqRNRTsfTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAK 211
Cdd:COG5576    36 DSEMKLERKQDGSSPP------KSK--RRRT--TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAK 105

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1587062636 212 WRREEKLRNQRRQASN--------TPSHIPIS 235
Cdd:COG5576   106 EKKKRSGKVEQRPGEEeadlakigSLSTGQIS 137
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
159-214 5.38e-28

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 104.12  E-value: 5.38e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1587062636 159 RNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRR 214
Cdd:pfam00046   2 RKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
PAX smart00351
Paired Box domain;
4-70 3.07e-26

Paired Box domain;


Pssm-ID: 128645 [Multi-domain]  Cd Length: 125  Bit Score: 101.63  E-value: 3.07e-26
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1587062636    4 SHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQthadakvqvldnqnVSNGCVSSI 70
Cdd:smart00351   1 GHGGVNQLGGVFVNGRPLPDEERQRIVELAQNGVRPCDISRQLC--------------VSHGCVSKI 53
PAX cd00131
Paired Box domain
 5-70 2.23e-25

Paired Box domain


Pssm-ID: 238076  Cd Length: 128  Bit Score: 99.42  E-value: 2.23e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1587062636   5 HSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQthadakvqvldnqnVSNGCVSSI 70
Cdd:cd00131     2 QGGVNQLGGVFVNGRPLPDSIRQRIVELAQSGIRPCDISRQLR--------------VSHGCVSKI 53
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 158-213 2.33e-24

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 94.24  E-value: 2.33e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1587062636  158 QRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWR 213
Cdd:smart00389   2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
PAX pfam00292
'Paired box' domain;
4-70 2.62e-24

'Paired box' domain;


Pssm-ID: 366005  Cd Length: 125  Bit Score: 96.48  E-value: 2.62e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1587062636   4 SHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQthadakvqvldnqnVSNGCVSSI 70
Cdd:pfam00292   1 GHGGVNQLGGVFVNGRPLPDHIRQKIVELAHSGVRPCDISRQLR--------------VSHGCVSKI 53
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 159-216 5.79e-24

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 93.46  E-value: 5.79e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1587062636 159 RNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREE 216
Cdd:cd00086     2 RKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
132-235 5.43e-12

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 63.22  E-value: 5.43e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1587062636 132 ENTNSISSNGEDSDEAqmrlqlKRKlqRNRTsfTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAK 211
Cdd:COG5576    36 DSEMKLERKQDGSSPP------KSK--RRRT--TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAK 105

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1587062636 212 WRREEKLRNQRRQASN--------TPSHIPIS 235
Cdd:COG5576   106 EKKKRSGKVEQRPGEEeadlakigSLSTGQIS 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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