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Conserved domains on  [gi|1573307399|ref|NP_001355557|]
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deoxyribonuclease TATDN1 isoform 3 [Mus musculus]

Protein Classification

TatD family hydrolase( domain architecture ID 10101392)

TatD family hydrolase is a metal-dependent hydrolase similar to Saccharomyces cerevisiae deoxyribonuclease Tat-D, a cytoplasmic protein that exhibits magnesium-dependent exo- and endonuclease activities, and to Homo sapiens deoxyribonuclease TATDN1 which catalyzes (in vitro) the decatenation of kinetoplast DNA

CATH:  3.20.20.140
EC:  3.1.-.-
Gene Ontology:  GO:0004536|GO:0046872|GO:0016788

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TatD_DNAse cd01310
TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent ...
1-247 1.22e-84

TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.


:

Pssm-ID: 238635 [Multi-domain]  Cd Length: 251  Bit Score: 252.49  E-value: 1.22e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573307399   1 MITGGSLQDSKDALQLAQTNDMFFSTVGCHPTRCDEFEkgspDQYLAGLLSLAENNKgkVVAIGECGLDFDRLQFcPKDT 80
Cdd:cd01310    33 IVVGTDLKSSKRALELAKKYDNVYAAVGLHPHDADEHV----DEDLDLLELLAANPK--VVAIGEIGLDYYRDKS-PREV 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573307399  81 QLKYFEKQFELSEQTQLPMFLHCRNSHTEFLDIMRRNRDRyVGGVVHSFDGTKEAAAALVDLGLYIGFNGCSLKTEAN-- 158
Cdd:cd01310   106 QKEVFRAQLELAKELNLPVVIHSRDAHEDVLEILKEYGPP-KRGVFHCFSGSAEEAKELLDLGFYISISGIVTFKNANel 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573307399 159 LEVLKSIPSEKLMIETDAPWCGVKSTHagskyintsfptkkkwenghclKDRNEPCHIIQILEIMSAVREEDPLELANTL 238
Cdd:cd01310   185 REVVKEIPLERLLLETDSPYLAPVPFR----------------------GKRNEPAYVKHVAEKIAELKGISVEEVAEVT 242

                  ....*....
gi 1573307399 239 YNNTIKVFF 247
Cdd:cd01310   243 TENAKRLFG 251
 
Name Accession Description Interval E-value
TatD_DNAse cd01310
TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent ...
1-247 1.22e-84

TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.


Pssm-ID: 238635 [Multi-domain]  Cd Length: 251  Bit Score: 252.49  E-value: 1.22e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573307399   1 MITGGSLQDSKDALQLAQTNDMFFSTVGCHPTRCDEFEkgspDQYLAGLLSLAENNKgkVVAIGECGLDFDRLQFcPKDT 80
Cdd:cd01310    33 IVVGTDLKSSKRALELAKKYDNVYAAVGLHPHDADEHV----DEDLDLLELLAANPK--VVAIGEIGLDYYRDKS-PREV 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573307399  81 QLKYFEKQFELSEQTQLPMFLHCRNSHTEFLDIMRRNRDRyVGGVVHSFDGTKEAAAALVDLGLYIGFNGCSLKTEAN-- 158
Cdd:cd01310   106 QKEVFRAQLELAKELNLPVVIHSRDAHEDVLEILKEYGPP-KRGVFHCFSGSAEEAKELLDLGFYISISGIVTFKNANel 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573307399 159 LEVLKSIPSEKLMIETDAPWCGVKSTHagskyintsfptkkkwenghclKDRNEPCHIIQILEIMSAVREEDPLELANTL 238
Cdd:cd01310   185 REVVKEIPLERLLLETDSPYLAPVPFR----------------------GKRNEPAYVKHVAEKIAELKGISVEEVAEVT 242

                  ....*....
gi 1573307399 239 YNNTIKVFF 247
Cdd:cd01310   243 TENAKRLFG 251
TatD COG0084
3'->5' ssDNA/RNA exonuclease TatD [Cell motility];
1-246 2.31e-68

3'->5' ssDNA/RNA exonuclease TatD [Cell motility];


Pssm-ID: 439854 [Multi-domain]  Cd Length: 253  Bit Score: 211.06  E-value: 2.31e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573307399   1 MITGGSLQDSKDALQLAQTNDMFFSTVGCHPTRCDEFekgsPDQYLAGLLSLAENNKgkVVAIGECGLDFDRlQFCPKDT 80
Cdd:COG0084    33 VVVGTDLESSERALELAERYPNVYAAVGLHPHDAKEH----DEEDLAELEELAAHPK--VVAIGEIGLDYYR-DKSPREV 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573307399  81 QLKYFEKQFELSEQTQLPMFLHCRNSHTEFLDIMRRNRDRYVGGVVHSFDGTKEAAAALVDLGLYIGFNG-CSLKTEANL 159
Cdd:COG0084   106 QEEAFRAQLALAKELGLPVIIHSRDAHDDTLEILKEEGAPALGGVFHCFSGSLEQAKRALDLGFYISFGGiVTFKNAKKL 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573307399 160 -EVLKSIPSEKLMIETDAPwcgvksthagskYInTSFPTKKKwenghclkdRNEPCHIIQILEIMSAVREEDPLELANTL 238
Cdd:COG0084   186 rEVAAAIPLDRLLLETDAP------------YL-APVPFRGK---------RNEPAYVPHVAEKLAELRGISLEELAEAT 243

                  ....*...
gi 1573307399 239 YNNTIKVF 246
Cdd:COG0084   244 TANARRLF 251
TatD_DNase pfam01026
TatD related DNase; This family of proteins are related to a large superfamily of ...
1-246 3.31e-67

TatD related DNase; This family of proteins are related to a large superfamily of metalloenzymes. TatD, a member of this family has been shown experimentally to be a DNase enzyme.


Pssm-ID: 425997 [Multi-domain]  Cd Length: 253  Bit Score: 208.27  E-value: 3.31e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573307399   1 MITGGSLQDSKDALQLAQTNDMF-FSTVGCHPTRCDEFEkgspDQYLAGLLSLAENnkGKVVAIGECGLDFDRLQFCPKD 79
Cdd:pfam01026  32 VVVGTDLEDFLRVLELAEKYPDRvYAAVGVHPHEADEAS----EDDLEALEKLAEH--PKVVAIGEIGLDYYYVDESPKE 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573307399  80 TQLKYFEKQFELSEQTQLPMFLHCRNSHTEFLDIMRRNRDRYVGGVVHSFDGTKEAAAALVDLGLYIGFNGCSLKTEANL 159
Cdd:pfam01026 106 AQEEVFRRQLELAKELGLPVVIHTRDAEEDLLEILKEAGAPGARGVLHCFTGSVEEARKFLDLGFYISISGIVTFKNAKK 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573307399 160 --EVLKSIPSEKLMIETDAPWCgvksthagskyinTSFPTKKKwenghclkdRNEPCHIIQILEIMSAVREEDPLELANT 237
Cdd:pfam01026 186 lrEVAAAIPLDRLLVETDAPYL-------------APVPYRGK---------RNEPAYVPYVVEKLAELKGISPEEVAEI 243

                  ....*....
gi 1573307399 238 LYNNTIKVF 246
Cdd:pfam01026 244 TTENAERLF 252
PRK10425 PRK10425
3'-5' ssDNA/RNA exonuclease TatD;
1-246 7.60e-47

3'-5' ssDNA/RNA exonuclease TatD;


Pssm-ID: 182449  Cd Length: 258  Bit Score: 156.37  E-value: 7.60e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573307399   1 MITGGSLQDSKDALQLAQTNDMFFSTVGCHPTRCDEFEKGSPDQylagLLSLAEnnKGKVVAIGECGLDFDRlQFCPKDT 80
Cdd:PRK10425   33 LITGTNLRESQQAQKLARQYPSCWSTAGVHPHDSSQWQAATEEA----IIELAA--QPEVVAIGECGLDFNR-NFSTPEE 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573307399  81 QLKYFEKQFELSEQTQLPMFLHCRNSHTEFLDIMRRNRDRYVGGVVHSFDGTKEAAAALVDLGLYIGFNG--CSLKTEAN 158
Cdd:PRK10425  106 QERAFVAQLAIAAELNMPVFMHCRDAHERFMALLEPWLDKLPGAVLHCFTGTREEMQACLARGLYIGITGwvCDERRGLE 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573307399 159 L-EVLKSIPSEKLMIETDAPWCGVKSTHAGskyintsfPTKKkwenghclkdRNEPCHIIQILEIMSAVREEDPLELANT 237
Cdd:PRK10425  186 LrELLPLIPAERLLLETDAPYLLPRDLTPK--------PASR----------RNEPAFLPHILQRIAHWRGEDAAWLAAT 247

                  ....*....
gi 1573307399 238 LYNNTIKVF 246
Cdd:PRK10425  248 TDANARTLF 256
TIGR00010 TIGR00010
hydrolase, TatD family; PSI-BLAST, starting with a urease alpha subunit, finds a large ...
1-246 8.58e-47

hydrolase, TatD family; PSI-BLAST, starting with a urease alpha subunit, finds a large superfamily of proteins, including a number of different enzymes that act as hydrolases at C-N bonds other than peptide bonds (EC 3.5.-.-), many uncharacterized proteins, and the members of this family. Several genomes have multiple paralogs related to this family. However, a set of 17 proteins can be found, one each from 17 of the first 20 genomes, such that each member forms a bidirectional best hit across genomes with all other members of the set. This core set (and one other near-perfect member), but not the other paralogs, form the seed for this model. Additionally, members of the seed alignment and all trusted hits, but not all paralogs, have a conserved motif DxHxH near the amino end. The member from E. coli was recently shown to have DNase activity. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272852 [Multi-domain]  Cd Length: 252  Bit Score: 155.88  E-value: 8.58e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573307399   1 MITGGSLQDSKDALQLAQTNDMFFSTVGCHPTRCDEFEKGSPDQylagLLSLAenNKGKVVAIGECGLDFdRLQFCPKDT 80
Cdd:TIGR00010  33 VAVGTDLEDFLRALELAEKYPNVYAAVGVHPLDVDDDTKEDIKE----LERLA--AHPKVVAIGETGLDY-YKADEYKRR 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573307399  81 QLKYFEKQFELSEQTQLPMFLHCRNSHTEFLDIMRRNRDRyVGGVVHSFDGTKEAAAALVDLGLYIGFNG-CSLKTEANL 159
Cdd:TIGR00010 106 QEEVFRAQLQLAEELNLPVIIHARDAEEDVLDILREEKPK-VGGVLHCFTGDAELAKKLLDLGFYISISGiVTFKNAKSL 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573307399 160 -EVLKSIPSEKLMIETDAPWCgvksthagskyinTSFPTKKKwenghclkdRNEPCHIIQILEIMSAVREEDPLELANTL 238
Cdd:TIGR00010 185 rEVVRKIPLERLLVETDSPYL-------------APVPYRGK---------RNEPAFVRYTVEAIAEIKGIDVEELAQIT 242

                  ....*...
gi 1573307399 239 YNNTIKVF 246
Cdd:TIGR00010 243 TKNAKRLF 250
 
Name Accession Description Interval E-value
TatD_DNAse cd01310
TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent ...
1-247 1.22e-84

TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.


Pssm-ID: 238635 [Multi-domain]  Cd Length: 251  Bit Score: 252.49  E-value: 1.22e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573307399   1 MITGGSLQDSKDALQLAQTNDMFFSTVGCHPTRCDEFEkgspDQYLAGLLSLAENNKgkVVAIGECGLDFDRLQFcPKDT 80
Cdd:cd01310    33 IVVGTDLKSSKRALELAKKYDNVYAAVGLHPHDADEHV----DEDLDLLELLAANPK--VVAIGEIGLDYYRDKS-PREV 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573307399  81 QLKYFEKQFELSEQTQLPMFLHCRNSHTEFLDIMRRNRDRyVGGVVHSFDGTKEAAAALVDLGLYIGFNGCSLKTEAN-- 158
Cdd:cd01310   106 QKEVFRAQLELAKELNLPVVIHSRDAHEDVLEILKEYGPP-KRGVFHCFSGSAEEAKELLDLGFYISISGIVTFKNANel 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573307399 159 LEVLKSIPSEKLMIETDAPWCGVKSTHagskyintsfptkkkwenghclKDRNEPCHIIQILEIMSAVREEDPLELANTL 238
Cdd:cd01310   185 REVVKEIPLERLLLETDSPYLAPVPFR----------------------GKRNEPAYVKHVAEKIAELKGISVEEVAEVT 242

                  ....*....
gi 1573307399 239 YNNTIKVFF 247
Cdd:cd01310   243 TENAKRLFG 251
TatD COG0084
3'->5' ssDNA/RNA exonuclease TatD [Cell motility];
1-246 2.31e-68

3'->5' ssDNA/RNA exonuclease TatD [Cell motility];


Pssm-ID: 439854 [Multi-domain]  Cd Length: 253  Bit Score: 211.06  E-value: 2.31e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573307399   1 MITGGSLQDSKDALQLAQTNDMFFSTVGCHPTRCDEFekgsPDQYLAGLLSLAENNKgkVVAIGECGLDFDRlQFCPKDT 80
Cdd:COG0084    33 VVVGTDLESSERALELAERYPNVYAAVGLHPHDAKEH----DEEDLAELEELAAHPK--VVAIGEIGLDYYR-DKSPREV 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573307399  81 QLKYFEKQFELSEQTQLPMFLHCRNSHTEFLDIMRRNRDRYVGGVVHSFDGTKEAAAALVDLGLYIGFNG-CSLKTEANL 159
Cdd:COG0084   106 QEEAFRAQLALAKELGLPVIIHSRDAHDDTLEILKEEGAPALGGVFHCFSGSLEQAKRALDLGFYISFGGiVTFKNAKKL 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573307399 160 -EVLKSIPSEKLMIETDAPwcgvksthagskYInTSFPTKKKwenghclkdRNEPCHIIQILEIMSAVREEDPLELANTL 238
Cdd:COG0084   186 rEVAAAIPLDRLLLETDAP------------YL-APVPFRGK---------RNEPAYVPHVAEKLAELRGISLEELAEAT 243

                  ....*...
gi 1573307399 239 YNNTIKVF 246
Cdd:COG0084   244 TANARRLF 251
TatD_DNase pfam01026
TatD related DNase; This family of proteins are related to a large superfamily of ...
1-246 3.31e-67

TatD related DNase; This family of proteins are related to a large superfamily of metalloenzymes. TatD, a member of this family has been shown experimentally to be a DNase enzyme.


Pssm-ID: 425997 [Multi-domain]  Cd Length: 253  Bit Score: 208.27  E-value: 3.31e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573307399   1 MITGGSLQDSKDALQLAQTNDMF-FSTVGCHPTRCDEFEkgspDQYLAGLLSLAENnkGKVVAIGECGLDFDRLQFCPKD 79
Cdd:pfam01026  32 VVVGTDLEDFLRVLELAEKYPDRvYAAVGVHPHEADEAS----EDDLEALEKLAEH--PKVVAIGEIGLDYYYVDESPKE 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573307399  80 TQLKYFEKQFELSEQTQLPMFLHCRNSHTEFLDIMRRNRDRYVGGVVHSFDGTKEAAAALVDLGLYIGFNGCSLKTEANL 159
Cdd:pfam01026 106 AQEEVFRRQLELAKELGLPVVIHTRDAEEDLLEILKEAGAPGARGVLHCFTGSVEEARKFLDLGFYISISGIVTFKNAKK 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573307399 160 --EVLKSIPSEKLMIETDAPWCgvksthagskyinTSFPTKKKwenghclkdRNEPCHIIQILEIMSAVREEDPLELANT 237
Cdd:pfam01026 186 lrEVAAAIPLDRLLVETDAPYL-------------APVPYRGK---------RNEPAYVPYVVEKLAELKGISPEEVAEI 243

                  ....*....
gi 1573307399 238 LYNNTIKVF 246
Cdd:pfam01026 244 TTENAERLF 252
PRK10425 PRK10425
3'-5' ssDNA/RNA exonuclease TatD;
1-246 7.60e-47

3'-5' ssDNA/RNA exonuclease TatD;


Pssm-ID: 182449  Cd Length: 258  Bit Score: 156.37  E-value: 7.60e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573307399   1 MITGGSLQDSKDALQLAQTNDMFFSTVGCHPTRCDEFEKGSPDQylagLLSLAEnnKGKVVAIGECGLDFDRlQFCPKDT 80
Cdd:PRK10425   33 LITGTNLRESQQAQKLARQYPSCWSTAGVHPHDSSQWQAATEEA----IIELAA--QPEVVAIGECGLDFNR-NFSTPEE 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573307399  81 QLKYFEKQFELSEQTQLPMFLHCRNSHTEFLDIMRRNRDRYVGGVVHSFDGTKEAAAALVDLGLYIGFNG--CSLKTEAN 158
Cdd:PRK10425  106 QERAFVAQLAIAAELNMPVFMHCRDAHERFMALLEPWLDKLPGAVLHCFTGTREEMQACLARGLYIGITGwvCDERRGLE 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573307399 159 L-EVLKSIPSEKLMIETDAPWCGVKSTHAGskyintsfPTKKkwenghclkdRNEPCHIIQILEIMSAVREEDPLELANT 237
Cdd:PRK10425  186 LrELLPLIPAERLLLETDAPYLLPRDLTPK--------PASR----------RNEPAFLPHILQRIAHWRGEDAAWLAAT 247

                  ....*....
gi 1573307399 238 LYNNTIKVF 246
Cdd:PRK10425  248 TDANARTLF 256
TIGR00010 TIGR00010
hydrolase, TatD family; PSI-BLAST, starting with a urease alpha subunit, finds a large ...
1-246 8.58e-47

hydrolase, TatD family; PSI-BLAST, starting with a urease alpha subunit, finds a large superfamily of proteins, including a number of different enzymes that act as hydrolases at C-N bonds other than peptide bonds (EC 3.5.-.-), many uncharacterized proteins, and the members of this family. Several genomes have multiple paralogs related to this family. However, a set of 17 proteins can be found, one each from 17 of the first 20 genomes, such that each member forms a bidirectional best hit across genomes with all other members of the set. This core set (and one other near-perfect member), but not the other paralogs, form the seed for this model. Additionally, members of the seed alignment and all trusted hits, but not all paralogs, have a conserved motif DxHxH near the amino end. The member from E. coli was recently shown to have DNase activity. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272852 [Multi-domain]  Cd Length: 252  Bit Score: 155.88  E-value: 8.58e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573307399   1 MITGGSLQDSKDALQLAQTNDMFFSTVGCHPTRCDEFEKGSPDQylagLLSLAenNKGKVVAIGECGLDFdRLQFCPKDT 80
Cdd:TIGR00010  33 VAVGTDLEDFLRALELAEKYPNVYAAVGVHPLDVDDDTKEDIKE----LERLA--AHPKVVAIGETGLDY-YKADEYKRR 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573307399  81 QLKYFEKQFELSEQTQLPMFLHCRNSHTEFLDIMRRNRDRyVGGVVHSFDGTKEAAAALVDLGLYIGFNG-CSLKTEANL 159
Cdd:TIGR00010 106 QEEVFRAQLQLAEELNLPVIIHARDAEEDVLDILREEKPK-VGGVLHCFTGDAELAKKLLDLGFYISISGiVTFKNAKSL 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573307399 160 -EVLKSIPSEKLMIETDAPWCgvksthagskyinTSFPTKKKwenghclkdRNEPCHIIQILEIMSAVREEDPLELANTL 238
Cdd:TIGR00010 185 rEVVRKIPLERLLVETDSPYL-------------APVPYRGK---------RNEPAFVRYTVEAIAEIKGIDVEELAQIT 242

                  ....*...
gi 1573307399 239 YNNTIKVF 246
Cdd:TIGR00010 243 TKNAKRLF 250
PRK11449 PRK11449
metal-dependent hydrolase;
14-246 4.32e-25

metal-dependent hydrolase;


Pssm-ID: 171118 [Multi-domain]  Cd Length: 258  Bit Score: 99.65  E-value: 4.32e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573307399  14 LQLAQTNDMFFSTVGCHPTRCDEFEKGSPDQYLAGLlslaENNKGKVVAIGECGLDF--DRLQFcpkDTQLKYFEKQFEL 91
Cdd:PRK11449   50 LALAERYQPLYAALGLHPGMLEKHSDVSLDQLQQAL----ERRPAKVVAVGEIGLDLfgDDPQF---ERQQWLLDEQLKL 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573307399  92 SEQTQLPMFLHCRNSHTEFLDIMRRnRDRYVGGVVHSFDGTKEAAAALVDLGLYIGFNGCSLKTEAN--LEVLKSIPSEK 169
Cdd:PRK11449  123 AKRYDLPVILHSRRTHDKLAMHLKR-HDLPRTGVVHGFSGSLQQAERFVQLGYKIGVGGTITYPRASktRDVIAKLPLAS 201
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1573307399 170 LMIETDAPwcgvksthagskyintSFPTkkkweNGHcLKDRNEPCHIIQILEIMSAVREEDPLELANTLYNNTIKVF 246
Cdd:PRK11449  202 LLLETDAP----------------DMPL-----NGF-QGQPNRPEQAARVFDVLCELRPEPADEIAEVLLNNTYTLF 256
PRK10812 PRK10812
putative DNAse; Provisional
16-178 9.68e-17

putative DNAse; Provisional


Pssm-ID: 236767 [Multi-domain]  Cd Length: 265  Bit Score: 77.10  E-value: 9.68e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573307399  16 LAQTNDMFFStVGCHPTRCDEfekgsPDQYlAGLLSLAENNKgkVVAIGECGLDFdrlqFCPKDT---QLKYFEKQFELS 92
Cdd:PRK10812   54 VGERDNVVFS-CGVHPLNQDE-----PYDV-EELRRLAAEEG--VVAMGETGLDY----YYTPETkvrQQESFRHHIQIG 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573307399  93 EQTQLPMFLHCRNSHTEFLDIMRRNRDRYVGGVVHSFDGTKEAAAALVDLGLYIGFNGCSL--KTEANLEVLKSIPSEKL 170
Cdd:PRK10812  121 RELNKPVIVHTRDARADTLAILREEKVTDCGGVLHCFTEDRETAGKLLDLGFYISFSGIVTfrNAEQLRDAARYVPLDRL 200

                  ....*...
gi 1573307399 171 MIETDAPW 178
Cdd:PRK10812  201 LVETDSPY 208
COG1099 COG1099
Predicted metal-dependent hydrolase, TIM-barrel fold [General function prediction only];
57-178 5.96e-05

Predicted metal-dependent hydrolase, TIM-barrel fold [General function prediction only];


Pssm-ID: 440716 [Multi-domain]  Cd Length: 260  Bit Score: 43.29  E-value: 5.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573307399  57 KGKVVAIGECGLDFDRlqfcpkDTQLKYFEKQFELSEQTQLPMFLHC--RN--SHTE-FLDIMRR---NRDRYVggVVHs 128
Cdd:COG1099    98 KEGVVAIGEIGLDDQT------PEEEEVFREQLELARELDLPVLVHTphRDkkEGTRrILDVLREsglDPERVL--IDH- 168
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1573307399 129 fdGTKEAAAALVDLGLYIGFN---GCSLKTEANLEVLKSIPSEKLMIETDAPW 178
Cdd:COG1099   169 --NNEETVKLVLDTGFWAGFTiypSTKMSPERAVDILEEYGTERILVNSAADW 219
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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