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Conserved domains on  [gi|1494862065|ref|NP_001353769|]
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leucine-rich repeat-containing protein 7 isoform 8 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
87-218 4.16e-28

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 109.64  E-value: 4.16e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862065  87 LEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPI 166
Cdd:COG4886   115 LESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQI 194

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1494862065 167 SKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPNI 218
Cdd:COG4886   195 TDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPEL 246
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
87-218 4.16e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 109.64  E-value: 4.16e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862065  87 LEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPI 166
Cdd:COG4886   115 LESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQI 194

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1494862065 167 SKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPNI 218
Cdd:COG4886   195 TDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPEL 246
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
90-216 5.11e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.55  E-value: 5.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862065  90 LYLDANQIEELPKqlfNCQA-LRKLSIPDNDLSNLPTTIASlvNLKELDISKNGVQEFPENIKccKCLTIIEASVNPISK 168
Cdd:PRK15370  204 LILDNNELKSLPE---NLQGnIKTLYANSNQLTSIPATLPD--TIQEMELSINRITELPERLP--SALQSLDLFHNKISC 276

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1494862065 169 LPDGFTQLLNLTQLYLND--AFLEFLPANFGRL---------------VKLRILELRENHLKTLP 216
Cdd:PRK15370  277 LPENLPEELRYLSVYDNSirTLPAHLPSGITHLnvqsnsltalpetlpPGLKTLEAGENALTSLP 341
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 81-217 8.92e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.78  E-value: 8.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862065  81 FNFERTLEELYLDANQIEELPkQLFNCQALRKLSIPDN---------DLSNL-------------------PTTIASLVN 132
Cdd:cd21340    42 LEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNrisvvegleNLTNLeelhienqrlppgekltfdPRSLAALSN 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862065 133 -LKELDISKNGVQEfPENIKCCKCLTIIEASVNPISKLPDgftqllnLTQLylndafleflpanFGRLVKLRILELRENH 211
Cdd:cd21340   121 sLRVLNISGNNIDS-LEPLAPLRNLEQLDASNNQISDLEE-------LLDL-------------LSSWPSLRELDLTGNP 179


                  ....*.
gi 1494862065 212 LKTLPN 217
Cdd:cd21340   180 VCKKPK 185
LRR_8 pfam13855
Leucine rich repeat;
85-141 5.09e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 5.09e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1494862065  85 RTLEELYLDANQIEELPKQLF-NCQALRKLSIPDNDLSNL-PTTIASLVNLKELDISKN 141
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFkGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGN 59
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
87-218 4.16e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 109.64  E-value: 4.16e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862065  87 LEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPI 166
Cdd:COG4886   115 LESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQI 194

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1494862065 167 SKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPNI 218
Cdd:COG4886   195 TDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPEL 246
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
87-216 8.79e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.30  E-value: 8.79e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862065  87 LEELYLDANqieelpKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPI 166
Cdd:COG4886    98 LTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQL 171

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1494862065 167 SKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLP 216
Cdd:COG4886   172 TDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLP 221
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
65-218 1.33e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.89  E-value: 1.33e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862065  65 VLDYSHCSLQQVPKEVFNFERtLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTtIASLVNLKELDISKNGVQ 144
Cdd:COG4886   186 ELDLSNNQITDLPEPLGNLTN-LEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLT 263

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1494862065 145 EFPENIKCCKcLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPNI 218
Cdd:COG4886   264 DLPPLANLTN-LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVT 336
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
82-217 4.55e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.18  E-value: 4.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862065  82 NFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNgvqefpENIKCCKCLTIIEA 161
Cdd:COG4886    47 LLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESLDL 120

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1494862065 162 SVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPN 217
Cdd:COG4886   121 SGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPE 176
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
90-216 5.11e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.55  E-value: 5.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862065  90 LYLDANQIEELPKqlfNCQA-LRKLSIPDNDLSNLPTTIASlvNLKELDISKNGVQEFPENIKccKCLTIIEASVNPISK 168
Cdd:PRK15370  204 LILDNNELKSLPE---NLQGnIKTLYANSNQLTSIPATLPD--TIQEMELSINRITELPERLP--SALQSLDLFHNKISC 276

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1494862065 169 LPDGFTQLLNLTQLYLND--AFLEFLPANFGRL---------------VKLRILELRENHLKTLP 216
Cdd:PRK15370  277 LPENLPEELRYLSVYDNSirTLPAHLPSGITHLnvqsnsltalpetlpPGLKTLEAGENALTSLP 341
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
86-216 3.20e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 56.24  E-value: 3.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862065  86 TLEELYLDANQIEELPKQLfnCQALRKLSIPDNDLSNLPTTIASlvNLKELDISKNGVQEFPENIKCckclTIIEASV-- 163
Cdd:PRK15370  242 TIQEMELSINRITELPERL--PSALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHLPS----GITHLNVqs 313

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1494862065 164 NPISKLPDgfTQLLNLTQLYLNDAFLEFLPANFGRlvKLRILELRENHLKTLP 216
Cdd:PRK15370  314 NSLTALPE--TLPPGLKTLEAGENALTSLPASLPP--ELQVLDVSKNQITVLP 362
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
87-177 7.97e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 52.01  E-value: 7.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862065  87 LEELYLDANQIEELPKQLfnCQALRKLSIPDNDLSNLPTTIASlvNLKELDISKNGVQEFPENIKCckCLTIIEASVNPI 166
Cdd:PRK15370  327 LKTLEAGENALTSLPASL--PPELQVLDVSKNQITVLPETLPP--TITTLDVSRNALTNLPENLPA--ALQIMQASRNNL 400

                          90
                  ....*....|.
gi 1494862065 167 SKLPDGFTQLL 177
Cdd:PRK15370  401 VRLPESLPHFR 411
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 86-216 2.06e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.00  E-value: 2.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862065  86 TLEELYLDANQIE-ELPkQLFNCQALRKLSIPDNDLSN-LPTTIASLVNLKELDISKNGVQ-EFPENIKCCKCLTIIEAS 162
Cdd:PLN00113  453 SLQMLSLARNKFFgGLP-DSFGSKRLENLDLSRNQFSGaVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLS 531

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1494862065 163 VNPIS-KLPDGFTQLLNLTQLYLNDAFLEF-LPANFGRLVKLRILELRENHLK-TLP 216
Cdd:PLN00113  532 HNQLSgQIPASFSEMPVLSQLDLSQNQLSGeIPKNLGNVESLVQVNISHNHLHgSLP 588
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 58-212 4.04e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.76  E-value: 4.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862065  58 GEEEIISVLDYSHCSLQ-QVPKEVFNFERtLEELYLDANQIE-ELPKQLFNCQALRKLSIPDNDLS-NLPTTIASLVNLK 134
Cdd:PLN00113  353 GKHNNLTVLDLSTNNLTgEIPEGLCSSGN-LFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVY 431

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862065 135 ELDISKNGVQefpENIKCCK----CLTIIEASVNPIS-KLPDGFTQlLNLTQLYLN-DAFLEFLPANFGRLVKLRILELR 208
Cdd:PLN00113  432 FLDISNNNLQ---GRINSRKwdmpSLQMLSLARNKFFgGLPDSFGS-KRLENLDLSrNQFSGAVPRKLGSLSELMQLKLS 507


                  ....
gi 1494862065 209 ENHL 212
Cdd:PLN00113  508 ENKL 511
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 81-217 8.92e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.78  E-value: 8.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862065  81 FNFERTLEELYLDANQIEELPkQLFNCQALRKLSIPDN---------DLSNL-------------------PTTIASLVN 132
Cdd:cd21340    42 LEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNrisvvegleNLTNLeelhienqrlppgekltfdPRSLAALSN 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862065 133 -LKELDISKNGVQEfPENIKCCKCLTIIEASVNPISKLPDgftqllnLTQLylndafleflpanFGRLVKLRILELRENH 211
Cdd:cd21340   121 sLRVLNISGNNIDS-LEPLAPLRNLEQLDASNNQISDLEE-------LLDL-------------LSSWPSLRELDLTGNP 179


                  ....*.
gi 1494862065 212 LKTLPN 217
Cdd:cd21340   180 VCKKPK 185
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 75-212 6.42e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.30  E-value: 6.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862065  75 QVPKEVFNFeRTLEELYLDANQIE-ELPKQLFNCQALRKLSIPDNDLS-------------------------NLPTTIA 128
Cdd:PLN00113  251 PIPSSLGNL-KNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgeipelviqlqnleilhlfsnnftgKIPVALT 329

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862065 129 SLVNLKELDISKNGVQ-EFPENIKCCKCLTIIEASVNPIS-KLPDGFTQLLNLTQLYLNDAFLEF-LPANFGRLVKLRIL 205
Cdd:PLN00113  330 SLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEGeIPKSLGACRSLRRV 409


                  ....*..
gi 1494862065 206 ELRENHL 212
Cdd:PLN00113  410 RLQDNSF 416
LRR_8 pfam13855
Leucine rich repeat;
85-141 5.09e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 5.09e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1494862065  85 RTLEELYLDANQIEELPKQLF-NCQALRKLSIPDNDLSNL-PTTIASLVNLKELDISKN 141
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFkGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGN 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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