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Conserved domains on  [gi|1488192480|ref|NP_001353525|]
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serine/arginine repetitive matrix protein 1 isoform 25 [Homo sapiens]

Protein Classification

PWI domain-containing protein( domain architecture ID 10478549)

PWI domain-containing protein may function as a splicing factor; similar to Homo sapiens serine/arginine repetitive matrix protein 1 that is involved in numerous pre-mRNA processing events

CATH:  1.20.1390.10
Gene Ontology:  GO:0006397|GO:0003676
PubMed:  10322432|12600940

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PWI pfam01480
PWI domain;
7-76 3.51e-38

PWI domain;


:

Pssm-ID: 460224 [Multi-domain]  Cd Length: 71  Bit Score: 136.48  E-value: 3.51e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192480   7 EVIKPWITKRVTEILGFEDDVVIEFIFNQLEVKNPDSKMMQINLTGFLNgKNAREFMGELWPLLLSAQEN 76
Cdd:pfam01480   1 EVLKPWIEKKITEILGFEDDVVVEYVVNLLEEKFPDPKELQIQLTGFLD-KDAAKFVKELWKLLLSAQES 69
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 551-685 7.40e-07

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 53.25  E-value: 7.40e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192480  551 PSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKhrkgSSPSRSTREARSPQPNKRHSPS 630
Cdd:PHA03307   275 WNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSS----TSSSSESSRGAAVSPGPSPSRS 350

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1488192480  631 PRP-RAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPS 685
Cdd:PHA03307   351 PSPsRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGR 406
PRK04195 super family cl35251
replication factor C large subunit; Provisional
 82-170 1.84e-03

replication factor C large subunit; Provisional


The actual alignment was detected with superfamily member PRK04195:

Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 41.83  E-value: 1.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192480  82 SAFLELKKEEIKQ--RQIEQEKLASMKKQDEDKdKRDKEEKESSREKRERSRSPRRTKSRSPSPAPEKKEKTPELPEPSV 159
Cdd:PRK04195  389 AAFLELTEEEIEFltGSKKATKKIKKIVEKAEK-KREEEKKEKKKKAFAGKKKEEEEEEEKEKKEEEKEEEEEEAEEEKE 467

                          90
                  ....*....|.
gi 1488192480 160 KVKEPSVQEAT 170
Cdd:PRK04195  468 EEEEKKKKQAT 478
 
Name Accession Description Interval E-value
PWI pfam01480
PWI domain;
7-76 3.51e-38

PWI domain;


Pssm-ID: 460224 [Multi-domain]  Cd Length: 71  Bit Score: 136.48  E-value: 3.51e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192480   7 EVIKPWITKRVTEILGFEDDVVIEFIFNQLEVKNPDSKMMQINLTGFLNgKNAREFMGELWPLLLSAQEN 76
Cdd:pfam01480   1 EVLKPWIEKKITEILGFEDDVVVEYVVNLLEEKFPDPKELQIQLTGFLD-KDAAKFVKELWKLLLSAQES 69
PWI smart00311
PWI, domain in splicing factors;
1-76 1.83e-28

PWI, domain in splicing factors;


Pssm-ID: 214609 [Multi-domain]  Cd Length: 74  Bit Score: 108.97  E-value: 1.83e-28
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1488192480    1 MSKVNLEVIKPWITKRVTEILGFEDDVVIEFIFNQLEV-KNPDSKMMQINLTGFLngkNAREFMGELWPLLLSAQEN 76
Cdd:smart00311   1 LSKLKLDEIKPWITKKVIEFLGFEEDTLVEFILSQIRQhKGPQAKLLQINLTGFE---DAEEFVDKLWRLLIFELKN 74
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 551-685 7.40e-07

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 53.25  E-value: 7.40e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192480  551 PSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKhrkgSSPSRSTREARSPQPNKRHSPS 630
Cdd:PHA03307   275 WNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSS----TSSSSESSRGAAVSPGPSPSRS 350

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1488192480  631 PRP-RAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPS 685
Cdd:PHA03307   351 PSPsRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGR 406
Retinal pfam15449
Retinal protein; This family of proteins is found in the photoreceptor cells of the retina. ...
 551-665 2.00e-04

Retinal protein; This family of proteins is found in the photoreceptor cells of the retina. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina.


Pssm-ID: 464722 [Multi-domain]  Cd Length: 1293  Bit Score: 45.15  E-value: 2.00e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192480  551 PSPPPKRRTASPPPPPKRrasPSPPPkrrVSHSPPPKQRSSPVTKRRSPSLSSkhrkGSSPSRSTREARSPQPNkRHSPS 630
Cdd:pfam15449 1072 LSPPTSKKRTSPPPQHKL---PSPPP---ESPPAQHKLSSPPTQRTEASSPSS----GPSPSPPTSPSQGHKET-RDSED 1140

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1488192480  631 PRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRP 665
Cdd:pfam15449 1141 SQAATAKASGNTCSIFCPATSSLFEAKSPFSTAHP 1175
PRK04195 PRK04195
replication factor C large subunit; Provisional
 82-170 1.84e-03

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 41.83  E-value: 1.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192480  82 SAFLELKKEEIKQ--RQIEQEKLASMKKQDEDKdKRDKEEKESSREKRERSRSPRRTKSRSPSPAPEKKEKTPELPEPSV 159
Cdd:PRK04195  389 AAFLELTEEEIEFltGSKKATKKIKKIVEKAEK-KREEEKKEKKKKAFAGKKKEEEEEEEKEKKEEEKEEEEEEAEEEKE 467

                          90
                  ....*....|.
gi 1488192480 160 KVKEPSVQEAT 170
Cdd:PRK04195  468 EEEEKKKKQAT 478
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 83-169 3.14e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 41.15  E-value: 3.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192480  83 AFLELKKEE---------IKQRQIEQE-KLASMKKQDEDKDKRDKEEKESSREKRERSR---SPRRTKSRSPSPAPEKKE 149
Cdd:NF033838  353 AELELVKEEakeprneekIKQAKAKVEsKKAEATRLEKIKTDRKKAEEEAKRKAAEEDKvkeKPAEQPQPAPAPQPEKPA 432

                          90       100
                  ....*....|....*....|
gi 1488192480 150 KTPELPEPSVKVKEPSVQEA 169
Cdd:NF033838  433 PKPEKPAEQPKAEKPADQQA 452
 
Name Accession Description Interval E-value
PWI pfam01480
PWI domain;
7-76 3.51e-38

PWI domain;


Pssm-ID: 460224 [Multi-domain]  Cd Length: 71  Bit Score: 136.48  E-value: 3.51e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192480   7 EVIKPWITKRVTEILGFEDDVVIEFIFNQLEVKNPDSKMMQINLTGFLNgKNAREFMGELWPLLLSAQEN 76
Cdd:pfam01480   1 EVLKPWIEKKITEILGFEDDVVVEYVVNLLEEKFPDPKELQIQLTGFLD-KDAAKFVKELWKLLLSAQES 69
PWI smart00311
PWI, domain in splicing factors;
1-76 1.83e-28

PWI, domain in splicing factors;


Pssm-ID: 214609 [Multi-domain]  Cd Length: 74  Bit Score: 108.97  E-value: 1.83e-28
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1488192480    1 MSKVNLEVIKPWITKRVTEILGFEDDVVIEFIFNQLEV-KNPDSKMMQINLTGFLngkNAREFMGELWPLLLSAQEN 76
Cdd:smart00311   1 LSKLKLDEIKPWITKKVIEFLGFEEDTLVEFILSQIRQhKGPQAKLLQINLTGFE---DAEEFVDKLWRLLIFELKN 74
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 551-685 7.40e-07

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 53.25  E-value: 7.40e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192480  551 PSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKhrkgSSPSRSTREARSPQPNKRHSPS 630
Cdd:PHA03307   275 WNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSS----TSSSSESSRGAAVSPGPSPSRS 350

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1488192480  631 PRP-RAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPS 685
Cdd:PHA03307   351 PSPsRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGR 406
PHA03247 PHA03247
large tegument protein UL36; Provisional
 480-675 4.20e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.71  E-value: 4.20e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192480  480 RWQSPVTKSGRRRRSPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRT 559
Cdd:PHA03247  2756 RPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQ 2835

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192480  560 ASPPPPPKRRASPSPP------PKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRkgSSPSRSTREARSPQPNKRHSPSPRP 633
Cdd:PHA03247  2836 PTAPPPPPGPPPPSLPlggsvaPGGDVRRRPPSRSPAAKPAAPARPPVRRLAR--PAVSRSTESFALPPDQPERPPQPQA 2913

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1488192480  634 RAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEP 675
Cdd:PHA03247  2914 PPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEP 2955
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 548-674 2.13e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 48.17  E-value: 2.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192480 548 RYSPSPPPKRRTASPPPPPKRRASPSPPPKR---RVSHSPPPKQRSSPVTkrrSPSLSSKHRKGSSPSRSTREARSPQPN 624
Cdd:PRK14951  367 AAAAEAAAPAEKKTPARPEAAAPAAAPVAQAaaaPAPAAAPAAAASAPAA---PPAAAPPAPVAAPAAAAPAAAPAAAPA 443

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1488192480 625 KRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPE 674
Cdd:PRK14951  444 AVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPTEE 493
PHA03247 PHA03247
large tegument protein UL36; Provisional
 536-730 2.41e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 2.41e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192480  536 PSPRRYSPPIQ------------RRYSPSPPPK----RRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSP 599
Cdd:PHA03247  2562 AAPDRSVPPPRpaprpsepavtsRARRPDAPPQsarpRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPH 2641

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192480  600 SLSS-----KHRKGSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPE 674
Cdd:PHA03247  2642 PPPTvpppeRPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPL 2721

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1488192480  675 PKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPspvqsQSPSTNWSPAVP 730
Cdd:PHA03247  2722 PPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARP-----PTTAGPPAPAPP 2772
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 554-685 6.87e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.70  E-value: 6.87e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192480  554 PPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSpqpnkrhSPSPRP 633
Cdd:PHA03307   266 PTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSS-------SESSRG 338

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1488192480  634 RA---------PQTSSSPPPVRRGasSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPS 685
Cdd:PHA03307   339 AAvspgpspsrSPSPSRPPPPADP--SSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGR 397
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 550-675 1.88e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 45.36  E-value: 1.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192480 550 SPSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSP 629
Cdd:PRK07764  620 APAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPA 699

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1488192480 630 SPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEP 675
Cdd:PRK07764  700 QPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEP 745
Retinal pfam15449
Retinal protein; This family of proteins is found in the photoreceptor cells of the retina. ...
 551-665 2.00e-04

Retinal protein; This family of proteins is found in the photoreceptor cells of the retina. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina.


Pssm-ID: 464722 [Multi-domain]  Cd Length: 1293  Bit Score: 45.15  E-value: 2.00e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192480  551 PSPPPKRRTASPPPPPKRrasPSPPPkrrVSHSPPPKQRSSPVTKRRSPSLSSkhrkGSSPSRSTREARSPQPNkRHSPS 630
Cdd:pfam15449 1072 LSPPTSKKRTSPPPQHKL---PSPPP---ESPPAQHKLSSPPTQRTEASSPSS----GPSPSPPTSPSQGHKET-RDSED 1140

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1488192480  631 PRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRP 665
Cdd:pfam15449 1141 SQAATAKASGNTCSIFCPATSSLFEAKSPFSTAHP 1175
Pneumo_att_G pfam05539
Pneumovirinae attachment membrane glycoprotein G;
553-687 2.48e-04

Pneumovirinae attachment membrane glycoprotein G;


Pssm-ID: 114270 [Multi-domain]  Cd Length: 408  Bit Score: 44.27  E-value: 2.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192480 553 PPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRhSPSPR 632
Cdd:pfam05539 168 PKTAVTTSKTTSWPTEVSHPTYPSQVTPQSQPATQGHQTATANQRLSSTEPVGTQGTTTSSNPEPQTEPPPSQR-GPSGS 246

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1488192480 633 PRAPQTSSSPPPVRRGASSS-PQRRQSP-SPS-TRPIRRVSRTPEPKKIKKAASPSPQ 687
Cdd:pfam05539 247 PQHPPSTTSQDQSTTGDGQEhTQRRKTPpATSnRRSPHSTATPPPTTKRQETGRPTPR 304
PI3K_1B_p101 pfam10486
Phosphoinositide 3-kinase gamma adapter protein p101 subunit; Class I PI3Ks are dual-specific ...
 563-647 2.72e-04

Phosphoinositide 3-kinase gamma adapter protein p101 subunit; Class I PI3Ks are dual-specific lipid and protein kinases involved in numerous intracellular signaling pathways. Class IB PI3K, p110gamma, is mainly activated by seven-transmembrane G-protein-coupled receptors (GPCRs), through its regulatory subunit p101 and G-protein beta-gamma subunits.


Pssm-ID: 463109  Cd Length: 860  Bit Score: 44.67  E-value: 2.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192480 563 PPPPKRRASPSPPPKRRVSHSP--------PPKqrsSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPSPRPR 634
Cdd:pfam10486 394 SSSSPRAEKPREKSKKKSRSRLsqriyrlfKPK---SPLVLRRAKSLGNPEAKDLIPVRSKRSNSLPQQVLLRSLEPPPL 470

                          90
                  ....*....|...
gi 1488192480 635 APQTSSSPPPVRR 647
Cdd:pfam10486 471 PPLSALRHVCFRR 483
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 554-686 3.27e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 44.30  E-value: 3.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192480 554 PPKRRTASPPPP--------PKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSlsSKHRKGSSPSRSTR-----EARS 620
Cdd:PTZ00449  510 PPEGPEASGLPPkapgdkegEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPGPA--KEHKPSKIPTLSKKpefpkDPKH 587

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1488192480 621 PQPNKRHSPSPRPRAPQTSSSPPPVRRGASS----SPQRRQSPS------PSTRPI--RRVSRTPEPKKIKKAASPSP 686
Cdd:PTZ00449  588 PKDPEEPKKPKRPRSAQRPTRPKSPKLPELLdipkSPKRPESPKspkrppPPQRPSspERPEGPKIIKSPKPPKSPKP 665
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 550-685 3.38e-04

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 44.33  E-value: 3.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192480 550 SPSPPPKRRTASPPpppkRRASPSPPPKRRVSHSPPPKQRSSPVTKRRsPSLSskhrKGSSPSRSTREARSPQPNKRHSP 629
Cdd:PHA03269   24 TNIPIPELHTSAAT----QKPDPAPAPHQAASRAPDPAVAPTSAASRK-PDLA----QAPTPAASEKFDPAPAPHQAASR 94

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1488192480 630 SPRPR-APQTSSSPPPVRRGA-SSSPQRRqsPSPSTRPIRRVSRTPEPKKIKKAASPS 685
Cdd:PHA03269   95 APDPAvAPQLAAAPKPDAAEAfTSAAQAH--EAPADAGTSAASKKPDPAAHTQHSPPP 150
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 550-650 4.36e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.82  E-value: 4.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192480 550 SPSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPK--QRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRH 627
Cdd:PRK07764  409 APAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGnaPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAP 488

                          90       100
                  ....*....|....*....|...
gi 1488192480 628 SPSPRPRAPQTSSSPPPVRRGAS 650
Cdd:PRK07764  489 APAAAPAAPAAPAAPAGADDAAT 511
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 548-665 5.17e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.82  E-value: 5.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192480 548 RYSPSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRH 627
Cdd:PRK07764  585 EAVVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASD 664

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1488192480 628 SPSPRP---RAPQTSSSPPPVRRGASSSPQRRQSPSPSTRP 665
Cdd:PRK07764  665 GGDGWPakaGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAP 705
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 566-686 7.19e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 43.24  E-value: 7.19e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192480  566 PKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPV 645
Cdd:PHA03307   256 PLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSES 335

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1488192480  646 RRGASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPSP 686
Cdd:PHA03307   336 SRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPS 376
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
551-661 1.36e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.17  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192480 551 PSPPPKRRTASPPPPPKRRASPSPPPKrrvSHSPPPKQRSSPvtKRRSPSL--------SSKHRKGSSPSRSTREARSPQ 622
Cdd:PRK12323  385 PAPAAAAPAAAAPAPAAPPAAPAAAPA---AAAAARAVAAAP--ARRSPAPealaaarqASARGPGGAPAPAPAPAAAPA 459

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1488192480 623 PNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSP 661
Cdd:PRK12323  460 AAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPP 498
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 550-654 1.69e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.90  E-value: 1.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192480 550 SPSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSP 629
Cdd:PRK07764  399 PSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTA 478

                          90       100
                  ....*....|....*....|....*
gi 1488192480 630 SPRPRAPQTSSSPPPVRRGASSSPQ 654
Cdd:PRK07764  479 APAPAPPAAPAPAAAPAAPAAPAAP 503
PRK04195 PRK04195
replication factor C large subunit; Provisional
 82-170 1.84e-03

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 41.83  E-value: 1.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192480  82 SAFLELKKEEIKQ--RQIEQEKLASMKKQDEDKdKRDKEEKESSREKRERSRSPRRTKSRSPSPAPEKKEKTPELPEPSV 159
Cdd:PRK04195  389 AAFLELTEEEIEFltGSKKATKKIKKIVEKAEK-KREEEKKEKKKKAFAGKKKEEEEEEEKEKKEEEKEEEEEEAEEEKE 467

                          90
                  ....*....|.
gi 1488192480 160 KVKEPSVQEAT 170
Cdd:PRK04195  468 EEEEKKKKQAT 478
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 546-676 1.84e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.08  E-value: 1.84e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192480  546 QRRYSPSPPPKRRTASPPPPPKRRASPSPP------PKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREA- 618
Cdd:PHA03307   781 QRGAGSSPPVRAEAAFRRPGRLRRSGPAADaasrtaSKRKSRSHTPDGGSESSGPARPPGAAARPPPARSSESSKSKPAa 860

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1488192480  619 ---RSPQPNKRHSPSPRPRAPQTSSSPPPV---RRGASSSPQRRQSPSPSTRPIRRVSRTPEPK 676
Cdd:PHA03307   861 aggRARGKNGRRRPRPPEPRARPGAAAPPKaaaAAPPAGAPAPRPRPAPRVKLGPMPPGGPDPR 924
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 575-732 2.03e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 41.98  E-value: 2.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192480 575 PPKRRVSHSPPPKQ--RSSPVTKRRSPSLSSKHRKGSSPSRSTREA---RSPQPNKRHSPSP------RPRAPQTSSSPp 643
Cdd:PTZ00449  510 PPEGPEASGLPPKApgDKEGEEGEHEDSKESDEPKEGGKPGETKEGevgKKPGPAKEHKPSKiptlskKPEFPKDPKHP- 588

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192480 644 pvRRgaSSSPQRRQSPSPSTRPIRRVS-RTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSPVQSQSPS 722
Cdd:PTZ00449  589 --KD--PEEPKKPKRPRSAQRPTRPKSpKLPELLDIPKSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKSPKPPKSPK 664

                         170
                  ....*....|
gi 1488192480 723 TNWSPAVPVK 732
Cdd:PTZ00449  665 PPFDPKFKEK 674
PHA03247 PHA03247
large tegument protein UL36; Provisional
 548-687 2.48e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 2.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192480  548 RYSPSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPN--- 624
Cdd:PHA03247  2773 AAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSlpl 2852

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1488192480  625 ----------KRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPSPQ 687
Cdd:PHA03247  2853 ggsvapggdvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPP 2925
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 83-169 3.14e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 41.15  E-value: 3.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192480  83 AFLELKKEE---------IKQRQIEQE-KLASMKKQDEDKDKRDKEEKESSREKRERSR---SPRRTKSRSPSPAPEKKE 149
Cdd:NF033838  353 AELELVKEEakeprneekIKQAKAKVEsKKAEATRLEKIKTDRKKAEEEAKRKAAEEDKvkeKPAEQPQPAPAPQPEKPA 432

                          90       100
                  ....*....|....*....|
gi 1488192480 150 KTPELPEPSVKVKEPSVQEA 169
Cdd:NF033838  433 PKPEKPAEQPKAEKPADQQA 452
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 556-675 3.81e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.85  E-value: 3.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192480 556 KRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSS---KHRKGSSPSRSTREARSPQPNKRHsPSPR 632
Cdd:PRK14951  365 KPAAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASapaAPPAAAPPAPVAAPAAAAPAAAPA-AAPA 443

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1488192480 633 PRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEP 675
Cdd:PRK14951  444 AVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAA 486
Gag_spuma pfam03276
Spumavirus gag protein;
551-660 8.30e-03

Spumavirus gag protein;


Pssm-ID: 460872 [Multi-domain]  Cd Length: 614  Bit Score: 39.73  E-value: 8.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192480 551 PSPPPKRRTASPPPPPK-------RRASPSPPPKRRVSHSPPPKQRSSPVTKRRSpslSSKHRKGSSPSRSTREARSPQP 623
Cdd:pfam03276 207 PAIPGIHARAPPGNIARslgddimPSLGDAGMPQPRFAFHPGNPFAEAEGHPFAE---AEGERPRDIPRAPRIDAPSAPA 283

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1488192480 624 NKRHSPSPRPrAPQTSSSPPPVRRGASSSPQRRQSPS 660
Cdd:pfam03276 284 IPAIQPIAPP-MIPPIGAPIPIPHGASIPGEHIRNPR 319
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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