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Conserved domains on  [gi|1488192388|ref|NP_001353505|]
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serine/arginine repetitive matrix protein 1 isoform 12 [Homo sapiens]

Protein Classification

PWI domain-containing protein( domain architecture ID 10478549)

PWI domain-containing protein may function as a splicing factor; similar to Homo sapiens serine/arginine repetitive matrix protein 1 that is involved in numerous pre-mRNA processing events

CATH:  1.20.1390.10
Gene Ontology:  GO:0006397|GO:0003676
PubMed:  10322432|12600940
SCOP:  4000671

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PWI pfam01480
PWI domain;
46-115 3.71e-38

PWI domain;


:

Pssm-ID: 460224 [Multi-domain]  Cd Length: 71  Bit Score: 136.48  E-value: 3.71e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388  46 EVIKPWITKRVTEILGFEDDVVIEFIFNQLEVKNPDSKMMQINLTGFLNgKNAREFMGELWPLLLSAQEN 115
Cdd:pfam01480   1 EVLKPWIEKKITEILGFEDDVVVEYVVNLLEEKFPDPKELQIQLTGFLD-KDAAKFVKELWKLLLSAQES 69
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 589-723 3.91e-07

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 54.02  E-value: 3.91e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388  589 PSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKhrkgSSPSRSTREARSPQPNKRHSPS 668
Cdd:PHA03307   275 WNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSS----TSSSSESSRGAAVSPGPSPSRS 350

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1488192388  669 PRP-RAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPS 723
Cdd:PHA03307   351 PSPsRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGR 406
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 384-713 7.28e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 7.28e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388  384 SPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEDKGGKMAAADSVQQRRQYRRQNQQSSS 463
Cdd:PHA03247  2615 SPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGS 2694

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388  464 DSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRMQMG-------KRWQSPVTKSGRRRRSPSPP 536
Cdd:PHA03247  2695 LTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGpatpggpARPARPPTTAGPPAPAPPAA 2774

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388  537 PTRRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRASPSPP--- 613
Cdd:PHA03247  2775 PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPlgg 2854

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388  614 ---PKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRkgSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSS 690
Cdd:PHA03247  2855 svaPGGDVRRRPPSRSPAAKPAAPARPPVRRLAR--PAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPP 2932

                          330       340
                   ....*....|....*....|...
gi 1488192388  691 PQRRQSPSPSTRPIRRVSRTPEP 713
Cdd:PHA03247  2933 PPPPPRPQPPLAPTTDPAGAGEP 2955
PRK04195 super family cl35251
replication factor C large subunit; Provisional
 121-209 1.59e-03

replication factor C large subunit; Provisional


The actual alignment was detected with superfamily member PRK04195:

Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 41.83  E-value: 1.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388 121 SAFLELKKEEIKQ--RQIEQEKLASMKKQDEDKdKRDKEEKESSREKRERSRSPRRTKSRSPSPAPEKKEKTPELPEPSV 198
Cdd:PRK04195  389 AAFLELTEEEIEFltGSKKATKKIKKIVEKAEK-KREEEKKEKKKKAFAGKKKEEEEEEEKEKKEEEKEEEEEEAEEEKE 467

                          90
                  ....*....|.
gi 1488192388 199 KVKEPSVQEAT 209
Cdd:PRK04195  468 EEEEKKKKQAT 478
 
Name Accession Description Interval E-value
PWI pfam01480
PWI domain;
46-115 3.71e-38

PWI domain;


Pssm-ID: 460224 [Multi-domain]  Cd Length: 71  Bit Score: 136.48  E-value: 3.71e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388  46 EVIKPWITKRVTEILGFEDDVVIEFIFNQLEVKNPDSKMMQINLTGFLNgKNAREFMGELWPLLLSAQEN 115
Cdd:pfam01480   1 EVLKPWIEKKITEILGFEDDVVVEYVVNLLEEKFPDPKELQIQLTGFLD-KDAAKFVKELWKLLLSAQES 69
PWI smart00311
PWI, domain in splicing factors;
40-115 1.91e-28

PWI, domain in splicing factors;


Pssm-ID: 214609 [Multi-domain]  Cd Length: 74  Bit Score: 108.97  E-value: 1.91e-28
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1488192388   40 MSKVNLEVIKPWITKRVTEILGFEDDVVIEFIFNQLEV-KNPDSKMMQINLTGFLngkNAREFMGELWPLLLSAQEN 115
Cdd:smart00311   1 LSKLKLDEIKPWITKKVIEFLGFEEDTLVEFILSQIRQhKGPQAKLLQINLTGFE---DAEEFVDKLWRLLIFELKN 74
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 589-723 3.91e-07

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 54.02  E-value: 3.91e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388  589 PSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKhrkgSSPSRSTREARSPQPNKRHSPS 668
Cdd:PHA03307   275 WNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSS----TSSSSESSRGAAVSPGPSPSRS 350

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1488192388  669 PRP-RAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPS 723
Cdd:PHA03307   351 PSPsRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGR 406
PHA03247 PHA03247
large tegument protein UL36; Provisional
 384-713 7.28e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 7.28e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388  384 SPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEDKGGKMAAADSVQQRRQYRRQNQQSSS 463
Cdd:PHA03247  2615 SPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGS 2694

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388  464 DSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRMQMG-------KRWQSPVTKSGRRRRSPSPP 536
Cdd:PHA03247  2695 LTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGpatpggpARPARPPTTAGPPAPAPPAA 2774

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388  537 PTRRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRASPSPP--- 613
Cdd:PHA03247  2775 PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPlgg 2854

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388  614 ---PKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRkgSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSS 690
Cdd:PHA03247  2855 svaPGGDVRRRPPSRSPAAKPAAPARPPVRRLAR--PAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPP 2932

                          330       340
                   ....*....|....*....|...
gi 1488192388  691 PQRRQSPSPSTRPIRRVSRTPEP 713
Cdd:PHA03247  2933 PPPPPRPQPPLAPTTDPAGAGEP 2955
Retinal pfam15449
Retinal protein; This family of proteins is found in the photoreceptor cells of the retina. ...
 589-703 8.90e-05

Retinal protein; This family of proteins is found in the photoreceptor cells of the retina. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina.


Pssm-ID: 464722 [Multi-domain]  Cd Length: 1293  Bit Score: 46.31  E-value: 8.90e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388  589 PSPPPKRRTASPPPPPKRrasPSPPPkrrVSHSPPPKQRSSPVTKRRSPSLSSkhrkGSSPSRSTREARSPQPNkRHSPS 668
Cdd:pfam15449 1072 LSPPTSKKRTSPPPQHKL---PSPPP---ESPPAQHKLSSPPTQRTEASSPSS----GPSPSPPTSPSQGHKET-RDSED 1140

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1488192388  669 PRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRP 703
Cdd:pfam15449 1141 SQAATAKASGNTCSIFCPATSSLFEAKSPFSTAHP 1175
PRK04195 PRK04195
replication factor C large subunit; Provisional
 121-209 1.59e-03

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 41.83  E-value: 1.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388 121 SAFLELKKEEIKQ--RQIEQEKLASMKKQDEDKdKRDKEEKESSREKRERSRSPRRTKSRSPSPAPEKKEKTPELPEPSV 198
Cdd:PRK04195  389 AAFLELTEEEIEFltGSKKATKKIKKIVEKAEK-KREEEKKEKKKKAFAGKKKEEEEEEEKEKKEEEKEEEEEEAEEEKE 467

                          90
                  ....*....|.
gi 1488192388 199 KVKEPSVQEAT 209
Cdd:PRK04195  468 EEEEKKKKQAT 478
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 122-208 2.30e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 41.54  E-value: 2.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388 122 AFLELKKEE---------IKQRQIEQE-KLASMKKQDEDKDKRDKEEKESSREKRERSR---SPRRTKSRSPSPAPEKKE 188
Cdd:NF033838  353 AELELVKEEakeprneekIKQAKAKVEsKKAEATRLEKIKTDRKKAEEEAKRKAAEEDKvkeKPAEQPQPAPAPQPEKPA 432

                          90       100
                  ....*....|....*....|
gi 1488192388 189 KTPELPEPSVKVKEPSVQEA 208
Cdd:NF033838  433 PKPEKPAEQPKAEKPADQQA 452
 
Name Accession Description Interval E-value
PWI pfam01480
PWI domain;
46-115 3.71e-38

PWI domain;


Pssm-ID: 460224 [Multi-domain]  Cd Length: 71  Bit Score: 136.48  E-value: 3.71e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388  46 EVIKPWITKRVTEILGFEDDVVIEFIFNQLEVKNPDSKMMQINLTGFLNgKNAREFMGELWPLLLSAQEN 115
Cdd:pfam01480   1 EVLKPWIEKKITEILGFEDDVVVEYVVNLLEEKFPDPKELQIQLTGFLD-KDAAKFVKELWKLLLSAQES 69
PWI smart00311
PWI, domain in splicing factors;
40-115 1.91e-28

PWI, domain in splicing factors;


Pssm-ID: 214609 [Multi-domain]  Cd Length: 74  Bit Score: 108.97  E-value: 1.91e-28
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1488192388   40 MSKVNLEVIKPWITKRVTEILGFEDDVVIEFIFNQLEV-KNPDSKMMQINLTGFLngkNAREFMGELWPLLLSAQEN 115
Cdd:smart00311   1 LSKLKLDEIKPWITKKVIEFLGFEEDTLVEFILSQIRQhKGPQAKLLQINLTGFE---DAEEFVDKLWRLLIFELKN 74
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 589-723 3.91e-07

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 54.02  E-value: 3.91e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388  589 PSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKhrkgSSPSRSTREARSPQPNKRHSPS 668
Cdd:PHA03307   275 WNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSS----TSSSSESSRGAAVSPGPSPSRS 350

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1488192388  669 PRP-RAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPS 723
Cdd:PHA03307   351 PSPsRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGR 406
PHA03247 PHA03247
large tegument protein UL36; Provisional
 384-713 7.28e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 7.28e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388  384 SPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEDKGGKMAAADSVQQRRQYRRQNQQSSS 463
Cdd:PHA03247  2615 SPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGS 2694

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388  464 DSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRMQMG-------KRWQSPVTKSGRRRRSPSPP 536
Cdd:PHA03247  2695 LTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGpatpggpARPARPPTTAGPPAPAPPAA 2774

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388  537 PTRRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRASPSPP--- 613
Cdd:PHA03247  2775 PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPlgg 2854

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388  614 ---PKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRkgSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSS 690
Cdd:PHA03247  2855 svaPGGDVRRRPPSRSPAAKPAAPARPPVRRLAR--PAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPP 2932

                          330       340
                   ....*....|....*....|...
gi 1488192388  691 PQRRQSPSPSTRPIRRVSRTPEP 713
Cdd:PHA03247  2933 PPPPPRPQPPLAPTTDPAGAGEP 2955
PHA03247 PHA03247
large tegument protein UL36; Provisional
 574-768 1.47e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.17  E-value: 1.47e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388  574 PSPRRYSPPIQ------------RRYSPSPPPK----RRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSP 637
Cdd:PHA03247  2562 AAPDRSVPPPRpaprpsepavtsRARRPDAPPQsarpRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPH 2641

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388  638 SLSS-----KHRKGSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPE 712
Cdd:PHA03247  2642 PPPTvpppeRPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPL 2721

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1488192388  713 PKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPspvqsQSPSTNWSPAVP 768
Cdd:PHA03247  2722 PPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARP-----PTTAGPPAPAPP 2772
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 586-712 1.70e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 48.56  E-value: 1.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388 586 RYSPSPPPKRRTASPPPPPKRRASPSPPPKR---RVSHSPPPKQRSSPVTkrrSPSLSSKHRKGSSPSRSTREARSPQPN 662
Cdd:PRK14951  367 AAAAEAAAPAEKKTPARPEAAAPAAAPVAQAaaaPAPAAAPAAAASAPAA---PPAAAPPAPVAAPAAAAPAAAPAAAPA 443

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1488192388 663 KRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPE 712
Cdd:PRK14951  444 AVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPTEE 493
Retinal pfam15449
Retinal protein; This family of proteins is found in the photoreceptor cells of the retina. ...
 589-703 8.90e-05

Retinal protein; This family of proteins is found in the photoreceptor cells of the retina. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina.


Pssm-ID: 464722 [Multi-domain]  Cd Length: 1293  Bit Score: 46.31  E-value: 8.90e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388  589 PSPPPKRRTASPPPPPKRrasPSPPPkrrVSHSPPPKQRSSPVTKRRSPSLSSkhrkGSSPSRSTREARSPQPNkRHSPS 668
Cdd:pfam15449 1072 LSPPTSKKRTSPPPQHKL---PSPPP---ESPPAQHKLSSPPTQRTEASSPSS----GPSPSPPTSPSQGHKET-RDSED 1140

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1488192388  669 PRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRP 703
Cdd:pfam15449 1141 SQAATAKASGNTCSIFCPATSSLFEAKSPFSTAHP 1175
Pneumo_att_G pfam05539
Pneumovirinae attachment membrane glycoprotein G;
591-725 1.26e-04

Pneumovirinae attachment membrane glycoprotein G;


Pssm-ID: 114270 [Multi-domain]  Cd Length: 408  Bit Score: 45.42  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388 591 PPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRhSPSPR 670
Cdd:pfam05539 168 PKTAVTTSKTTSWPTEVSHPTYPSQVTPQSQPATQGHQTATANQRLSSTEPVGTQGTTTSSNPEPQTEPPPSQR-GPSGS 246

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1488192388 671 PRAPQTSSSPPPVRRGASSS-PQRRQSP-SPS-TRPIRRVSRTPEPKKIKKAASPSPQ 725
Cdd:pfam05539 247 PQHPPSTTSQDQSTTGDGQEhTQRRKTPpATSnRRSPHSTATPPPTTKRQETGRPTPR 304
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 592-724 1.32e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 45.84  E-value: 1.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388 592 PPKRRTASPPPP--------PKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSlsSKHRKGSSPSRSTR-----EARS 658
Cdd:PTZ00449  510 PPEGPEASGLPPkapgdkegEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPGPA--KEHKPSKIPTLSKKpefpkDPKH 587

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1488192388 659 PQPNKRHSPSPRPRAPQTSSSPPPVRRGASS----SPQRRQSPS------PSTRPI--RRVSRTPEPKKIKKAASPSP 724
Cdd:PTZ00449  588 PKDPEEPKKPKRPRSAQRPTRPKSPKLPELLdipkSPKRPESPKspkrppPPQRPSspERPEGPKIIKSPKPPKSPKP 665
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 588-713 1.37e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 45.75  E-value: 1.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388 588 SPSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSP 667
Cdd:PRK07764  620 APAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPA 699

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1488192388 668 SPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEP 713
Cdd:PRK07764  700 QPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEP 745
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 588-723 1.88e-04

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 45.10  E-value: 1.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388 588 SPSPPPKRRTASPPpppkRRASPSPPPKRRVSHSPPPKQRSSPVTKRRsPSLSskhrKGSSPSRSTREARSPQPNKRHSP 667
Cdd:PHA03269   24 TNIPIPELHTSAAT----QKPDPAPAPHQAASRAPDPAVAPTSAASRK-PDLA----QAPTPAASEKFDPAPAPHQAASR 94

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1488192388 668 SPRPR-APQTSSSPPPVRRGA-SSSPQRRqsPSPSTRPIRRVSRTPEPKKIKKAASPS 723
Cdd:PHA03269   95 APDPAvAPQLAAAPKPDAAEAfTSAAQAH--EAPADAGTSAASKKPDPAAHTQHSPPP 150
PI3K_1B_p101 pfam10486
Phosphoinositide 3-kinase gamma adapter protein p101 subunit; Class I PI3Ks are dual-specific ...
 601-685 2.21e-04

Phosphoinositide 3-kinase gamma adapter protein p101 subunit; Class I PI3Ks are dual-specific lipid and protein kinases involved in numerous intracellular signaling pathways. Class IB PI3K, p110gamma, is mainly activated by seven-transmembrane G-protein-coupled receptors (GPCRs), through its regulatory subunit p101 and G-protein beta-gamma subunits.


Pssm-ID: 463109  Cd Length: 860  Bit Score: 45.06  E-value: 2.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388 601 PPPPKRRASPSPPPKRRVSHSP--------PPKqrsSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPSPRPR 672
Cdd:pfam10486 394 SSSSPRAEKPREKSKKKSRSRLsqriyrlfKPK---SPLVLRRAKSLGNPEAKDLIPVRSKRSNSLPQQVLLRSLEPPPL 470

                          90
                  ....*....|...
gi 1488192388 673 APQTSSSPPPVRR 685
Cdd:pfam10486 471 PPLSALRHVCFRR 483
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 588-688 3.36e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.59  E-value: 3.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388 588 SPSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPK--QRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRH 665
Cdd:PRK07764  409 APAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGnaPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAP 488

                          90       100
                  ....*....|....*....|...
gi 1488192388 666 SPSPRPRAPQTSSSPPPVRRGAS 688
Cdd:PRK07764  489 APAAAPAAPAAPAAPAGADDAAT 511
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 586-703 4.16e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.21  E-value: 4.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388 586 RYSPSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRH 665
Cdd:PRK07764  585 EAVVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASD 664

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1488192388 666 SPSPRP---RAPQTSSSPPPVRRGASSSPQRRQSPSPSTRP 703
Cdd:PRK07764  665 GGDGWPakaGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAP 705
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 604-724 4.93e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.01  E-value: 4.93e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388  604 PKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPV 683
Cdd:PHA03307   256 PLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSES 335

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1488192388  684 RRGASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPSP 724
Cdd:PHA03307   336 SRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPS 376
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 584-714 8.99e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 43.24  E-value: 8.99e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388  584 QRRYSPSPPPKRRTASPPPPPKRRASPSPP------PKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREA- 656
Cdd:PHA03307   781 QRGAGSSPPVRAEAAFRRPGRLRRSGPAADaasrtaSKRKSRSHTPDGGSESSGPARPPGAAARPPPARSSESSKSKPAa 860

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1488192388  657 ---RSPQPNKRHSPSPRPRAPQTSSSPPPV---RRGASSSPQRRQSPSPSTRPIRRVSRTPEPK 714
Cdd:PHA03307   861 aggRARGKNGRRRPRPPEPRARPGAAAPPKaaaAAPPAGAPAPRPRPAPRVKLGPMPPGGPDPR 924
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
589-699 1.06e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.94  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388 589 PSPPPKRRTASPPPPPKRRASPSPPPKrrvSHSPPPKQRSSPvtKRRSPSL--------SSKHRKGSSPSRSTREARSPQ 660
Cdd:PRK12323  385 PAPAAAAPAAAAPAPAAPPAAPAAAPA---AAAAARAVAAAP--ARRSPAPealaaarqASARGPGGAPAPAPAPAAAPA 459

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1488192388 661 PNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSP 699
Cdd:PRK12323  460 AAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPP 498
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 613-770 1.18e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 42.75  E-value: 1.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388 613 PPKRRVSHSPPPKQ--RSSPVTKRRSPSLSSKHRKGSSPSRSTREA---RSPQPNKRHSPSP------RPRAPQTSSSPp 681
Cdd:PTZ00449  510 PPEGPEASGLPPKApgDKEGEEGEHEDSKESDEPKEGGKPGETKEGevgKKPGPAKEHKPSKiptlskKPEFPKDPKHP- 588

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388 682 pvRRgaSSSPQRRQSPSPSTRPIRRVS-RTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSPVQSQSPS 760
Cdd:PTZ00449  589 --KD--PEEPKKPKRPRSAQRPTRPKSpKLPELLDIPKSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKSPKPPKSPK 664

                         170
                  ....*....|
gi 1488192388 761 TNWSPAVPVK 770
Cdd:PTZ00449  665 PPFDPKFKEK 674
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 588-692 1.32e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.67  E-value: 1.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388 588 SPSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSP 667
Cdd:PRK07764  399 PSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTA 478

                          90       100
                  ....*....|....*....|....*
gi 1488192388 668 SPRPRAPQTSSSPPPVRRGASSSPQ 692
Cdd:PRK07764  479 APAPAPPAAPAPAAAPAAPAAPAAP 503
PRK04195 PRK04195
replication factor C large subunit; Provisional
 121-209 1.59e-03

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 41.83  E-value: 1.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388 121 SAFLELKKEEIKQ--RQIEQEKLASMKKQDEDKdKRDKEEKESSREKRERSRSPRRTKSRSPSPAPEKKEKTPELPEPSV 198
Cdd:PRK04195  389 AAFLELTEEEIEFltGSKKATKKIKKIVEKAEK-KREEEKKEKKKKAFAGKKKEEEEEEEKEKKEEEKEEEEEEAEEEKE 467

                          90
                  ....*....|.
gi 1488192388 199 KVKEPSVQEAT 209
Cdd:PRK04195  468 EEEEKKKKQAT 478
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 122-208 2.30e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 41.54  E-value: 2.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388 122 AFLELKKEE---------IKQRQIEQE-KLASMKKQDEDKDKRDKEEKESSREKRERSR---SPRRTKSRSPSPAPEKKE 188
Cdd:NF033838  353 AELELVKEEakeprneekIKQAKAKVEsKKAEATRLEKIKTDRKKAEEEAKRKAAEEDKvkeKPAEQPQPAPAPQPEKPA 432

                          90       100
                  ....*....|....*....|
gi 1488192388 189 KTPELPEPSVKVKEPSVQEA 208
Cdd:NF033838  433 PKPEKPAEQPKAEKPADQQA 452
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 594-713 3.25e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 41.24  E-value: 3.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388 594 KRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSS---KHRKGSSPSRSTREARSPQPNKRHsPSPR 670
Cdd:PRK14951  365 KPAAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASapaAPPAAAPPAPVAAPAAAAPAAAPA-AAPA 443

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1488192388 671 PRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEP 713
Cdd:PRK14951  444 AVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAA 486
Gag_spuma pfam03276
Spumavirus gag protein;
589-698 3.59e-03

Spumavirus gag protein;


Pssm-ID: 460872 [Multi-domain]  Cd Length: 614  Bit Score: 40.89  E-value: 3.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488192388 589 PSPPPKRRTASPPPPPK-------RRASPSPPPKRRVSHSPPPKQRSSPVTKRRSpslSSKHRKGSSPSRSTREARSPQP 661
Cdd:pfam03276 207 PAIPGIHARAPPGNIARslgddimPSLGDAGMPQPRFAFHPGNPFAEAEGHPFAE---AEGERPRDIPRAPRIDAPSAPA 283

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1488192388 662 NKRHSPSPRPrAPQTSSSPPPVRRGASSSPQRRQSPS 698
Cdd:pfam03276 284 IPAIQPIAPP-MIPPIGAPIPIPHGASIPGEHIRNPR 319
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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