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Conserved domains on  [gi|1483453002|ref|NP_001353198|]
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protein archease isoform 12 [Homo sapiens]

Protein Classification

archease( domain architecture ID 10487813)

archease is a component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of the catalytic subunit RTCB

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Archease pfam01951
Archease protein family (MTH1598/TM1083); This archease family of proteins, has two SHS2 ...
 6-88 1.68e-30

Archease protein family (MTH1598/TM1083); This archease family of proteins, has two SHS2 domains, with one inserted into another. It is predicted to be an enzyme. It is predicted to act as a chaperone in DNA/RNA metabolism.


:

Pssm-ID: 426527  Cd Length: 136  Bit Score: 104.92  E-value: 1.68e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483453002   6 LHAWGDTLEEAFEQCAMAMFGYMTDTGTVEPLQTVEVETQGDDLQSLLFHFLDEWLYKFSADEFfiprVGRRIFIVQAPS 85
Cdd:pfam01951  12 IEAWGPTLEEAFENAALAMFELMTDLSKVEPKEEREIEVEGEDLEDLLVDWLDELLYLFDTEGL----VFSRFEIEEEED 87


                  ...
gi 1483453002  86 GNR 88
Cdd:pfam01951  88 GYR 90
 
Name Accession Description Interval E-value
Archease pfam01951
Archease protein family (MTH1598/TM1083); This archease family of proteins, has two SHS2 ...
 6-88 1.68e-30

Archease protein family (MTH1598/TM1083); This archease family of proteins, has two SHS2 domains, with one inserted into another. It is predicted to be an enzyme. It is predicted to act as a chaperone in DNA/RNA metabolism.


Pssm-ID: 426527  Cd Length: 136  Bit Score: 104.92  E-value: 1.68e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483453002   6 LHAWGDTLEEAFEQCAMAMFGYMTDTGTVEPLQTVEVETQGDDLQSLLFHFLDEWLYKFSADEFfiprVGRRIFIVQAPS 85
Cdd:pfam01951  12 IEAWGPTLEEAFENAALAMFELMTDLSKVEPKEEREIEVEGEDLEDLLVDWLDELLYLFDTEGL----VFSRFEIEEEED 87


                  ...
gi 1483453002  86 GNR 88
Cdd:pfam01951  88 GYR 90
ARCH COG1371
Archease, activates RNA ligation by RtcB (tRNA splicing) [Translation, ribosomal structure and ...
 8-69 1.69e-21

Archease, activates RNA ligation by RtcB (tRNA splicing) [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440982  Cd Length: 139  Bit Score: 82.15  E-value: 1.69e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1483453002   8 AWGDTLEEAFEQCAMAMFGYMTDTGTVEPLQTVEVETQGDDLQSLLFHFLDEWLYKFSADEF 69
Cdd:COG1371    16 AYGPTLEEAFANAALALFALMVDTSKVEPREEREIEVEAEDLEDLLVDWLNELLYLFDTEGL 77
Archease PRK00407
Archease protein family (MTH1598/TM1083); This archease family of proteins, has two SHS2 ...
 8-62 6.74e-17

Archease protein family (MTH1598/TM1083); This archease family of proteins, has two SHS2 domains, with one inserted into another. It is predicted to be an enzyme. It is predicted to act as a chaperone in DNA/RNA metabolism.


Pssm-ID: 179008  Cd Length: 139  Bit Score: 70.43  E-value: 6.74e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1483453002   8 AWGDTLEEAFEQCAMAMFGYMTDTGTVEPLQTVEVETQGDDLQSLLFHFLDEWLY 62
Cdd:PRK00407   17 AYGRTLEEAFENAALAVFDVITDTSKVEPKEEREIEIEGYDLENLLYRWLEELLY 71
 
Name Accession Description Interval E-value
Archease pfam01951
Archease protein family (MTH1598/TM1083); This archease family of proteins, has two SHS2 ...
 6-88 1.68e-30

Archease protein family (MTH1598/TM1083); This archease family of proteins, has two SHS2 domains, with one inserted into another. It is predicted to be an enzyme. It is predicted to act as a chaperone in DNA/RNA metabolism.


Pssm-ID: 426527  Cd Length: 136  Bit Score: 104.92  E-value: 1.68e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483453002   6 LHAWGDTLEEAFEQCAMAMFGYMTDTGTVEPLQTVEVETQGDDLQSLLFHFLDEWLYKFSADEFfiprVGRRIFIVQAPS 85
Cdd:pfam01951  12 IEAWGPTLEEAFENAALAMFELMTDLSKVEPKEEREIEVEGEDLEDLLVDWLDELLYLFDTEGL----VFSRFEIEEEED 87


                  ...
gi 1483453002  86 GNR 88
Cdd:pfam01951  88 GYR 90
ARCH COG1371
Archease, activates RNA ligation by RtcB (tRNA splicing) [Translation, ribosomal structure and ...
 8-69 1.69e-21

Archease, activates RNA ligation by RtcB (tRNA splicing) [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440982  Cd Length: 139  Bit Score: 82.15  E-value: 1.69e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1483453002   8 AWGDTLEEAFEQCAMAMFGYMTDTGTVEPLQTVEVETQGDDLQSLLFHFLDEWLYKFSADEF 69
Cdd:COG1371    16 AYGPTLEEAFANAALALFALMVDTSKVEPREEREIEVEAEDLEDLLVDWLNELLYLFDTEGL 77
Archease PRK00407
Archease protein family (MTH1598/TM1083); This archease family of proteins, has two SHS2 ...
 8-62 6.74e-17

Archease protein family (MTH1598/TM1083); This archease family of proteins, has two SHS2 domains, with one inserted into another. It is predicted to be an enzyme. It is predicted to act as a chaperone in DNA/RNA metabolism.


Pssm-ID: 179008  Cd Length: 139  Bit Score: 70.43  E-value: 6.74e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1483453002   8 AWGDTLEEAFEQCAMAMFGYMTDTGTVEPLQTVEVETQGDDLQSLLFHFLDEWLY 62
Cdd:PRK00407   17 AYGRTLEEAFENAALAVFDVITDTSKVEPKEEREIEIEGYDLENLLYRWLEELLY 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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