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Conserved domains on  [gi|1434520708|ref|NP_001352017|]
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solute carrier family 12 member 6 isoform a [Homo sapiens]

Protein Classification

solute carrier family 12 protein( domain architecture ID 11489985)

solute carrier family 12 protein similar to Arabidopsis thaliana cation-chloride cotransporter 1, which mediates both potassium-chloride and sodium-chloride cotransports and is involved in plant development and Cl(-) homeostasis

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
109-1150 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


:

Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1357.85  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  109 HKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKP-TKTPQMGT 187
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDAEGTKEKPpAGAVKFGW 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  188 FMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGA 267
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  268 VGLCFYLGTTFAAAMYILGAIEIFLvyivpraAIFHSDdALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLF 347
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVL-------DLLREN-GSKIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLF 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  348 LACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTlssrhidvcsktkeinnmtvpsklwgffcnssqffnatcdeyFVHN 427
Cdd:TIGR00930  233 LVIVLLSILNIFVGTIIPAFDKPAKGFFGLGNEI------------------------------------------FSEN 270
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  428 NvtsIQGIPGLASGiitenlwsnylpkgeiiekpsakssdvlgslnheyvlvdittsFTLLVGIFFPSVTGIMAGSNRSG 507
Cdd:TIGR00930  271 F---IPGIPGPEGG-------------------------------------------FFSLFGIFFPSVTGILAGANISG 304
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  508 DLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVK---------------------GNLVVGTLSW 566
Cdd:TIGR00930  305 DLKDPQKAIPKGTLLAILTTTVVYLGSVVLFGACVVRDATGDKNDTLVTnctsaacfsecahntcsyglmNNLQVMSLVS 384
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  567 PSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTAAIAELGILIASLDLVAPI 645
Cdd:TIGR00930  385 PFPPLITAGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGkNGEPLRAYLLTAFIAEGFILIAELNTIAPI 464
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  646 LSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKE 725
Cdd:TIGR00930  465 ISNFFLASYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVN 544
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  726 WGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDedlhVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYG 805
Cdd:TIGR00930  545 WGSSTQALSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPP----VCRPALLDFASQFTKGKGLMICGSVIQGPRLECVK 620
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  806 EALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEdARAWKTFIGTVRVTTA 885
Cdd:TIGR00930  621 EAQAAEAKIQTWLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAE-PRAWETYIGIIHDAFD 699
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  886 AHLALLVAKNISFFPSNV--------------------------------------EQFSEGNIDVWWIVHDGGMLMLLP 927
Cdd:TIGR00930  700 AHLAVVVVRNSEGLPISVlqvqeelendcsedsielndgkistqpdmhleastqfqKKQGKGTIDVWWLVDDGGLTLLLP 779
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  928 FLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMhdsDISAytYERTLMMEQRSQMLRHMRLS 1007
Cdd:TIGR00930  780 YLLTTKKVWKKCKIRIFVGAQKDDRSEQEKKDMATLLYKFRIDAEVIVVLM---DINA--KPQTESMEAFEEMIRPFRLH 854
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708 1008 KTERDREAqlvKDRnsmlrltsigsdedeetetyqekvHMTWTKDKYMASrgqkaksmegfQDLlnmrpdQSNVRRMHTA 1087
Cdd:TIGR00930  855 KTEKDREA---KDP------------------------KMTWTKPWKITD-----------AEL------QSNVRKSYRQ 890
                         1050      1060      1070      1080      1090      1100
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1434520708 1088 VKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1150
Cdd:TIGR00930  891 VRLNELLLEYSRDAALVVLSLPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
109-1150 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1357.85  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  109 HKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKP-TKTPQMGT 187
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDAEGTKEKPpAGAVKFGW 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  188 FMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGA 267
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  268 VGLCFYLGTTFAAAMYILGAIEIFLvyivpraAIFHSDdALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLF 347
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVL-------DLLREN-GSKIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLF 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  348 LACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTlssrhidvcsktkeinnmtvpsklwgffcnssqffnatcdeyFVHN 427
Cdd:TIGR00930  233 LVIVLLSILNIFVGTIIPAFDKPAKGFFGLGNEI------------------------------------------FSEN 270
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  428 NvtsIQGIPGLASGiitenlwsnylpkgeiiekpsakssdvlgslnheyvlvdittsFTLLVGIFFPSVTGIMAGSNRSG 507
Cdd:TIGR00930  271 F---IPGIPGPEGG-------------------------------------------FFSLFGIFFPSVTGILAGANISG 304
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  508 DLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVK---------------------GNLVVGTLSW 566
Cdd:TIGR00930  305 DLKDPQKAIPKGTLLAILTTTVVYLGSVVLFGACVVRDATGDKNDTLVTnctsaacfsecahntcsyglmNNLQVMSLVS 384
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  567 PSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTAAIAELGILIASLDLVAPI 645
Cdd:TIGR00930  385 PFPPLITAGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGkNGEPLRAYLLTAFIAEGFILIAELNTIAPI 464
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  646 LSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKE 725
Cdd:TIGR00930  465 ISNFFLASYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVN 544
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  726 WGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDedlhVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYG 805
Cdd:TIGR00930  545 WGSSTQALSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPP----VCRPALLDFASQFTKGKGLMICGSVIQGPRLECVK 620
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  806 EALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEdARAWKTFIGTVRVTTA 885
Cdd:TIGR00930  621 EAQAAEAKIQTWLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAE-PRAWETYIGIIHDAFD 699
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  886 AHLALLVAKNISFFPSNV--------------------------------------EQFSEGNIDVWWIVHDGGMLMLLP 927
Cdd:TIGR00930  700 AHLAVVVVRNSEGLPISVlqvqeelendcsedsielndgkistqpdmhleastqfqKKQGKGTIDVWWLVDDGGLTLLLP 779
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  928 FLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMhdsDISAytYERTLMMEQRSQMLRHMRLS 1007
Cdd:TIGR00930  780 YLLTTKKVWKKCKIRIFVGAQKDDRSEQEKKDMATLLYKFRIDAEVIVVLM---DINA--KPQTESMEAFEEMIRPFRLH 854
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708 1008 KTERDREAqlvKDRnsmlrltsigsdedeetetyqekvHMTWTKDKYMASrgqkaksmegfQDLlnmrpdQSNVRRMHTA 1087
Cdd:TIGR00930  855 KTEKDREA---KDP------------------------KMTWTKPWKITD-----------AEL------QSNVRKSYRQ 890
                         1050      1060      1070      1080      1090      1100
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1434520708 1088 VKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1150
Cdd:TIGR00930  891 VRLNELLLEYSRDAALVVLSLPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
AA_permease pfam00324
Amino acid permease;
190-760 7.98e-49

Amino acid permease;


Pssm-ID: 366028 [Multi-domain]  Cd Length: 467  Bit Score: 180.98  E-value: 7.98e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  190 GVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVpAGGSYFMISRALGPEFGGAVG 269
Cdd:pfam00324    1 HVQMIALGGVIGTGLFVGSGSVLGQAGPAGALLGYLISGVVIFLVMLSLGEISTNGPV-SGGFYTYASRFLGPSLGFATG 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  270 L--CFYLGTTFAAAmyiLGAIEIFLVYIVPRAAIfhsddalkesaamlNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLF 347
Cdd:pfam00324   80 WnyWLSWITVLALE---LTAASILIQFWELVPDI--------------PYLWVWGAVFLVLLTIINLVGVKWYGEAEFWF 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  348 LACVIVSILAIYAGAI--KSSFAPPHFPVcmlgnrtlssrhidvcsktkeinnmtvpsklwgffcnssqffnatcdEYFV 425
Cdd:pfam00324  143 ALIKIIAIIGFIIVGIilLSGGNPNDGAI-----------------------------------------------FRYL 175
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  426 HNNVTSIQGIPGLASGIItenlwsnylpkgeiiekpsakssdvlgslnheYVLVdittsftllvgIFFPSVTGIMAGSNR 505
Cdd:pfam00324  176 GDNGGKNNFPPGFGKGFI--------------------------------SVFV-----------IAFFAFTGIELVGIA 212
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  506 SGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEG--VVLRDKFGDAVKGNLVVGTLSWPS--PWVIVIGSFFSTC 581
Cdd:pfam00324  213 AGEVKNPEKSIPKAILQVIWRITIFYILSLLAIGLLVPWndPGLLNDSASAASPFVIFFKFLGISglAPLINAVILTAAL 292
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  582 GAGLQSLTGAPRLLQAIAKDNIIPFlrVFGHSKANGEPTWALLLTAAIAELGILIASLdlVAPILSMFFLMCYLFVNLAC 661
Cdd:pfam00324  293 SAANSSLYSGSRMLYSLARDGLAPK--FLKKVDKRGVPLRAILVSMVISLLALLLASL--NPAIVFNFLLAISGLSGLIV 368
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  662 ALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFA 741
Cdd:pfam00324  369 WGLISLSHLRFRKAFKYQGRSIDELPFKAPLGPLGVILGLAAIIIILIIQFLYAFLPVPGGPKNWGAGSFAAAYLIVLLF 448
                          570
                   ....*....|....*....
gi 1434520708  742 LLRLEEGPPHTKNWRPQLL 760
Cdd:pfam00324  449 LIILIGVKLHVKNWKPQLL 467
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
198-720 1.36e-35

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 141.19  E-value: 1.36e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  198 NIFGVILFLRLTWVVGTAG--VLQAFAIVLICCcctMLTAISMSAIATNgvVP-AGGSYFMISRALGPEFGGAVGLCFYL 274
Cdd:COG0531     25 AIIGAGIFVLPGLAAGLAGpaAILAWLIAGLLA---LLVALSYAELASA--FPrAGGAYTYARRALGPLLGFLAGWALLL 99
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  275 GTTFAAAMYILGAIEiFLVYIVPRAAIFhsddalkesaamlnnmrVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVS 354
Cdd:COG0531    100 SYVLAVAAVAVAFGG-YLSSLFPAGGSV-----------------LIALVLILLLTLLNLRGVKESAKVNNILTVLKLLV 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  355 ILAIYAGAIkSSFAPPHFpvcmlgnrtlssrhidvcsktkeinnmtvpsklwgffcnsSQFFNATcdeyfvhnnvtsiQG 434
Cdd:COG0531    162 LLLFIVVGL-FAFDPANF----------------------------------------TPFLPAG-------------GG 187
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  435 IPGLASGIitenlwsnylpkgeiiekpsakssdvlgslnheyvlvdittsftllvGIFFPSVTGIMAGSNRSGDLKDAQK 514
Cdd:COG0531    188 LSGVLAAL-----------------------------------------------ALAFFAFTGFEAIANLAEEAKNPKR 220
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  515 SIPIGTILAILTTSFVYlsnvVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSP--WVIVIGSFFSTCGAGLQSLTGAP 592
Cdd:COG0531    221 NIPRAIILSLLIVGVLY----ILVSLALTGVVPYDELAASGAPLADAAEAVFGPWgaILIALGALLSLLGALNASILGAS 296
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  593 RLLQAIAKDNIIPflRVFGH-SKANGEPTWALLLTAAIAELGILI--ASLDLVAPILSMFFLMCYLFVNLAcALQTLLRT 669
Cdd:COG0531    297 RLLYAMARDGLLP--KVFAKvHPRFGTPVNAILLTGVIALLLLLLgaASFTALASLASVGVLLAYLLVALA-VIVLRRRR 373
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1434520708  670 PNWRPRFRYYHWALSFMGMSICLALMFIS---SWYYAIVAMVIAGMIYKYIEYQ 720
Cdd:COG0531    374 PDLPRPFRVPLPLIPILGILLCLFLLYLLgpgALLIGLVLLAIGLLLYLLYRRR 427
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
109-1150 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1357.85  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  109 HKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKP-TKTPQMGT 187
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDAEGTKEKPpAGAVKFGW 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  188 FMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGA 267
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  268 VGLCFYLGTTFAAAMYILGAIEIFLvyivpraAIFHSDdALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLF 347
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVL-------DLLREN-GSKIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLF 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  348 LACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTlssrhidvcsktkeinnmtvpsklwgffcnssqffnatcdeyFVHN 427
Cdd:TIGR00930  233 LVIVLLSILNIFVGTIIPAFDKPAKGFFGLGNEI------------------------------------------FSEN 270
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  428 NvtsIQGIPGLASGiitenlwsnylpkgeiiekpsakssdvlgslnheyvlvdittsFTLLVGIFFPSVTGIMAGSNRSG 507
Cdd:TIGR00930  271 F---IPGIPGPEGG-------------------------------------------FFSLFGIFFPSVTGILAGANISG 304
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  508 DLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVK---------------------GNLVVGTLSW 566
Cdd:TIGR00930  305 DLKDPQKAIPKGTLLAILTTTVVYLGSVVLFGACVVRDATGDKNDTLVTnctsaacfsecahntcsyglmNNLQVMSLVS 384
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  567 PSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTAAIAELGILIASLDLVAPI 645
Cdd:TIGR00930  385 PFPPLITAGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGkNGEPLRAYLLTAFIAEGFILIAELNTIAPI 464
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  646 LSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKE 725
Cdd:TIGR00930  465 ISNFFLASYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVN 544
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  726 WGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDedlhVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYG 805
Cdd:TIGR00930  545 WGSSTQALSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPP----VCRPALLDFASQFTKGKGLMICGSVIQGPRLECVK 620
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  806 EALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEdARAWKTFIGTVRVTTA 885
Cdd:TIGR00930  621 EAQAAEAKIQTWLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAE-PRAWETYIGIIHDAFD 699
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  886 AHLALLVAKNISFFPSNV--------------------------------------EQFSEGNIDVWWIVHDGGMLMLLP 927
Cdd:TIGR00930  700 AHLAVVVVRNSEGLPISVlqvqeelendcsedsielndgkistqpdmhleastqfqKKQGKGTIDVWWLVDDGGLTLLLP 779
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  928 FLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMhdsDISAytYERTLMMEQRSQMLRHMRLS 1007
Cdd:TIGR00930  780 YLLTTKKVWKKCKIRIFVGAQKDDRSEQEKKDMATLLYKFRIDAEVIVVLM---DINA--KPQTESMEAFEEMIRPFRLH 854
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708 1008 KTERDREAqlvKDRnsmlrltsigsdedeetetyqekvHMTWTKDKYMASrgqkaksmegfQDLlnmrpdQSNVRRMHTA 1087
Cdd:TIGR00930  855 KTEKDREA---KDP------------------------KMTWTKPWKITD-----------AEL------QSNVRKSYRQ 890
                         1050      1060      1070      1080      1090      1100
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1434520708 1088 VKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1150
Cdd:TIGR00930  891 VRLNELLLEYSRDAALVVLSLPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
AA_permease pfam00324
Amino acid permease;
190-760 7.98e-49

Amino acid permease;


Pssm-ID: 366028 [Multi-domain]  Cd Length: 467  Bit Score: 180.98  E-value: 7.98e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  190 GVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVpAGGSYFMISRALGPEFGGAVG 269
Cdd:pfam00324    1 HVQMIALGGVIGTGLFVGSGSVLGQAGPAGALLGYLISGVVIFLVMLSLGEISTNGPV-SGGFYTYASRFLGPSLGFATG 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  270 L--CFYLGTTFAAAmyiLGAIEIFLVYIVPRAAIfhsddalkesaamlNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLF 347
Cdd:pfam00324   80 WnyWLSWITVLALE---LTAASILIQFWELVPDI--------------PYLWVWGAVFLVLLTIINLVGVKWYGEAEFWF 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  348 LACVIVSILAIYAGAI--KSSFAPPHFPVcmlgnrtlssrhidvcsktkeinnmtvpsklwgffcnssqffnatcdEYFV 425
Cdd:pfam00324  143 ALIKIIAIIGFIIVGIilLSGGNPNDGAI-----------------------------------------------FRYL 175
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  426 HNNVTSIQGIPGLASGIItenlwsnylpkgeiiekpsakssdvlgslnheYVLVdittsftllvgIFFPSVTGIMAGSNR 505
Cdd:pfam00324  176 GDNGGKNNFPPGFGKGFI--------------------------------SVFV-----------IAFFAFTGIELVGIA 212
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  506 SGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEG--VVLRDKFGDAVKGNLVVGTLSWPS--PWVIVIGSFFSTC 581
Cdd:pfam00324  213 AGEVKNPEKSIPKAILQVIWRITIFYILSLLAIGLLVPWndPGLLNDSASAASPFVIFFKFLGISglAPLINAVILTAAL 292
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  582 GAGLQSLTGAPRLLQAIAKDNIIPFlrVFGHSKANGEPTWALLLTAAIAELGILIASLdlVAPILSMFFLMCYLFVNLAC 661
Cdd:pfam00324  293 SAANSSLYSGSRMLYSLARDGLAPK--FLKKVDKRGVPLRAILVSMVISLLALLLASL--NPAIVFNFLLAISGLSGLIV 368
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  662 ALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFA 741
Cdd:pfam00324  369 WGLISLSHLRFRKAFKYQGRSIDELPFKAPLGPLGVILGLAAIIIILIIQFLYAFLPVPGGPKNWGAGSFAAAYLIVLLF 448
                          570
                   ....*....|....*....
gi 1434520708  742 LLRLEEGPPHTKNWRPQLL 760
Cdd:pfam00324  449 LIILIGVKLHVKNWKPQLL 467
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
198-720 1.36e-35

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 141.19  E-value: 1.36e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  198 NIFGVILFLRLTWVVGTAG--VLQAFAIVLICCcctMLTAISMSAIATNgvVP-AGGSYFMISRALGPEFGGAVGLCFYL 274
Cdd:COG0531     25 AIIGAGIFVLPGLAAGLAGpaAILAWLIAGLLA---LLVALSYAELASA--FPrAGGAYTYARRALGPLLGFLAGWALLL 99
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  275 GTTFAAAMYILGAIEiFLVYIVPRAAIFhsddalkesaamlnnmrVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVS 354
Cdd:COG0531    100 SYVLAVAAVAVAFGG-YLSSLFPAGGSV-----------------LIALVLILLLTLLNLRGVKESAKVNNILTVLKLLV 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  355 ILAIYAGAIkSSFAPPHFpvcmlgnrtlssrhidvcsktkeinnmtvpsklwgffcnsSQFFNATcdeyfvhnnvtsiQG 434
Cdd:COG0531    162 LLLFIVVGL-FAFDPANF----------------------------------------TPFLPAG-------------GG 187
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  435 IPGLASGIitenlwsnylpkgeiiekpsakssdvlgslnheyvlvdittsftllvGIFFPSVTGIMAGSNRSGDLKDAQK 514
Cdd:COG0531    188 LSGVLAAL-----------------------------------------------ALAFFAFTGFEAIANLAEEAKNPKR 220
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  515 SIPIGTILAILTTSFVYlsnvVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSP--WVIVIGSFFSTCGAGLQSLTGAP 592
Cdd:COG0531    221 NIPRAIILSLLIVGVLY----ILVSLALTGVVPYDELAASGAPLADAAEAVFGPWgaILIALGALLSLLGALNASILGAS 296
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  593 RLLQAIAKDNIIPflRVFGH-SKANGEPTWALLLTAAIAELGILI--ASLDLVAPILSMFFLMCYLFVNLAcALQTLLRT 669
Cdd:COG0531    297 RLLYAMARDGLLP--KVFAKvHPRFGTPVNAILLTGVIALLLLLLgaASFTALASLASVGVLLAYLLVALA-VIVLRRRR 373
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1434520708  670 PNWRPRFRYYHWALSFMGMSICLALMFIS---SWYYAIVAMVIAGMIYKYIEYQ 720
Cdd:COG0531    374 PDLPRPFRVPLPLIPILGILLCLFLLYLLgpgALLIGLVLLAIGLLLYLLYRRR 427
SLC12 pfam03522
Solute carrier family 12;
774-1150 5.28e-31

Solute carrier family 12;


Pssm-ID: 460955  Cd Length: 414  Bit Score: 126.96  E-value: 5.28e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  774 PRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEqtIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKH 853
Cdd:pfam03522    2 PALVDFAHLITKNVSLMICGHVVKGRLSQKLRSELQKK--AYRWLRKRKIKAFYALVDGDNLREGAQALLQASGLGKLKP 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  854 NTVVMGWPNGWRQSE------------DA--------------------------------------------------- 870
Cdd:pfam03522   80 NILLMGYKSDWRTCDkeeleeyfnvihDAfdlqyavailrlpegldvshllqdqdteelglgdetnssyaeqsseeqsts 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  871 --RAWKTFIGTVRVTTAAHLALLV-------------------AKNISFFPSNVE--------QF----SEGNIDVWWIV 917
Cdd:pfam03522  160 nsKQDDDKSKLSKKDSNLSLSPDKstknpsgkdssksdklkkkSPSIILRTASNEkeilnnitQFqkkqKKGTIDVWWLY 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  918 HDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIE-AEVEVVemhdSDISAYTYERTLMMEQ 996
Cdd:pfam03522  240 DDGGLTLLLPYILSTRSKWSDCKLRVFALGNRKDELEEEQRNMASLLSKFRIDySDLTVI----PDITKKPKKETKKFFD 315
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  997 rsQMLRHMRLSKTERDREaqlvkdrnSMLRLTsigsdeDEETETYQEKVHmtwtkdkymasrgqkaksmegfqdlLNMRp 1076
Cdd:pfam03522  316 --ELIEPFRLHEDDKEEE--------SAEKIT------DSELEALKEKTN-------------------------RQLR- 353
                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1434520708 1077 dqsnvrrmhtavkLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1150
Cdd:pfam03522  354 -------------LRELLLEHSSDANLIVMTLPMPRKGTVSAPLYMAWLETLTKDLPPFLLVRGNQTSVLTFYS 414
AA_permease_2 pfam13520
Amino acid permease;
481-717 8.27e-15

Amino acid permease;


Pssm-ID: 404414 [Multi-domain]  Cd Length: 427  Bit Score: 78.12  E-value: 8.27e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  481 ITTSFTLLVGIFFpSVTGIMAGSNRSGDLKdaQKSIPIGTILAILTTSFVY-LSNVVLFGAC-IEGVVLRDKFGD---AV 555
Cdd:pfam13520  187 WPGVFAGFLGVLW-SFTGFESAANVSEEVK--KRNVPKAIFIGVIIVGVLYiLVNIAFFGVVpDDEIALSSGLGQvaaLL 263
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  556 KGNLVVGTLSWpspwVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGIL 635
Cdd:pfam13520  264 FQAVGGKWGAI----IVVILLALSLLGAVNTAIVGASRLLYALARDGVLPFSRFFAKVNKFGSPIRAIILTAILSLILLL 339
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  636 IASLDLVAPI----LSMFFLMCYLFVNLACALqtLLRTPNWRPRFRYYHWALSFMGMsICLALMFISSWYYAIVAMVIAG 711
Cdd:pfam13520  340 LFLLSPAAYNallsLSAYGYLLSYLLPIIGLL--ILRKKRPDLGRIPGRWPVAIFGI-LFSLFLIVALFFPPVGPATGSS 416

                   ....*.
gi 1434520708  712 MIYKYI 717
Cdd:pfam13520  417 LNYAII 422
2A0308 TIGR00911
L-type amino acid transporter; [Transport and binding proteins, Amino acids, peptides and ...
507-706 5.89e-05

L-type amino acid transporter; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273332 [Multi-domain]  Cd Length: 501  Bit Score: 47.05  E-value: 5.89e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  507 GDLKDAQKSIPIGTILAILTTSFVY-LSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPwvIVIGsfFSTCGAGL 585
Cdd:TIGR00911  259 EEVKNPYRTLPIAIIISMPIVTFIYvLTNIAYFTVLSPEELLASLAVAVDFGERLLGVMSWAMP--ALVG--LSCFGSVN 334
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1434520708  586 QSLTGAPRLLQAIAKDNIIPFLRVFGHSKANgEPTWALLLTAAIAELGILIASLDLVAPILSMFFlmcYLFVNLACALQT 665
Cdd:TIGR00911  335 GSLFSSSRLFFVGGREGHLPSLLSMIHVKRL-TPLPSLLIVCTLTLLMLFSGDIYSLINLISFAN---WLFNALAVAGLL 410
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1434520708  666 LLR--TPNWRPRFRyyhwalsfmgMSICLALMFISSWYYAIVA 706
Cdd:TIGR00911  411 WLRykRPEMNRPIK----------VPLFFPVFFLLSCLFLIIL 443
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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