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Conserved domains on  [gi|1418360167|ref|NP_001351678|]
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prostate tumor-overexpressed gene 1 protein isoform 4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Med25 pfam11232
Mediator complex subunit 25 PTOV activation and synapsin 2; Mediator is a large complex of up ...
 104-253 3.24e-74

Mediator complex subunit 25 PTOV activation and synapsin 2; Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species. It is arranged into four different sections, a core, a head, a tail and a kinase-active part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA domain, an SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This family is the combined PTOV and SD2 domains. the PTOV domain being the domain through which Med25 co-operates with the histone acetyltransferase CBP, but the function of the SD2 domain is unclear.


:

Pssm-ID: 463243  Cd Length: 154  Bit Score: 229.15  E-value: 3.24e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418360167 104 SNKLLAWSGVLEWQEKRrpySDSTAKLKRTLPCQ--AYVNQGE-NLETDQWPQKLIMQLIPQQLLTTLG-PLFRNSQLAQ 179
Cdd:pfam11232   1 SQRELIWSGVLEWQEKM---SDQNPKITRTLPCQvsNSVKNGEpELKAEKWPQKLIMQLMPKTLLGNIGgALLRNSRVVV 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1418360167 180 FHFTNRDCDSLKGLCRIMGNGFAGCMLF---PHISPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVSAIRQVITTRKQ 253
Cdd:pfam11232  78 FHFTPTDLEALKSLYRVMSNGFAGCVHFpgiPANPQCDIKVLMLLYSPKKNAFMGLIPNDQAAFVNRLRQVIKKQKQ 154
Med25 pfam11232
Mediator complex subunit 25 PTOV activation and synapsin 2; Mediator is a large complex of up ...
 269-414 1.06e-72

Mediator complex subunit 25 PTOV activation and synapsin 2; Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species. It is arranged into four different sections, a core, a head, a tail and a kinase-active part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA domain, an SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This family is the combined PTOV and SD2 domains. the PTOV domain being the domain through which Med25 co-operates with the histone acetyltransferase CBP, but the function of the SD2 domain is unclear.


:

Pssm-ID: 463243  Cd Length: 154  Bit Score: 225.30  E-value: 1.06e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418360167 269 NNKFLAWSGVMEWQEPRPEPNSRSKRWLPSHV--YVNQGE-ILRTEQWPRKLYMQLIPQQLLTTLV-PLFRNSRLVQFHF 344
Cdd:pfam11232   1 SQRELIWSGVLEWQEKMSDQNPKITRTLPCQVsnSVKNGEpELKAEKWPQKLIMQLMPKTLLGNIGgALLRNSRVVVFHF 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1418360167 345 T-KDLETLKSLCRIMDNGFAGCVHF---SYKASCEIRVLMLLYSSEKKIFIGLIPHDQGNFVNGIRRVIANQQQ 414
Cdd:pfam11232  81 TpTDLEALKSLYRVMSNGFAGCVHFpgiPANPQCDIKVLMLLYSPKKNAFMGLIPNDQAAFVNRLRQVIKKQKQ 154
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
1-156 1.88e-05

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK14950:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 585  Bit Score: 46.73  E-value: 1.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418360167   1 MRSPAVPTPARGQLGVAFVLLPPHSVGAPVPATPPEvvaRASSQDSPAPERPAGPPSPHSAPARAPLPRAALEGARVFGA 80
Cdd:PRK14950  368 PAKPTAAAPSPVRPTPAPSTRPKAAAAANIPPKEPV---RETATPPPVPPRPVAPPVPHTPESAPKLTRAAIPVDEKPKY 444

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418360167  81 LGPIGPSSPGLTLGGLAVSEHRLSNkllAWSGVLEWQEKR------------RPYSDSTAKLKRTLPCQAYVNQGENLET 148
Cdd:PRK14950  445 TPPAPPKEEEKALIADGDVLEQLEA---IWKQILRDVPPRspavqallssgvRPVSVEKNTLTLSFKSKFHKDKIEEPEN 521


                  ....*...
gi 1418360167 149 DQWPQKLI 156
Cdd:PRK14950  522 RKITEELL 529
 
Name Accession Description Interval E-value
Med25 pfam11232
Mediator complex subunit 25 PTOV activation and synapsin 2; Mediator is a large complex of up ...
 104-253 3.24e-74

Mediator complex subunit 25 PTOV activation and synapsin 2; Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species. It is arranged into four different sections, a core, a head, a tail and a kinase-active part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA domain, an SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This family is the combined PTOV and SD2 domains. the PTOV domain being the domain through which Med25 co-operates with the histone acetyltransferase CBP, but the function of the SD2 domain is unclear.


Pssm-ID: 463243  Cd Length: 154  Bit Score: 229.15  E-value: 3.24e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418360167 104 SNKLLAWSGVLEWQEKRrpySDSTAKLKRTLPCQ--AYVNQGE-NLETDQWPQKLIMQLIPQQLLTTLG-PLFRNSQLAQ 179
Cdd:pfam11232   1 SQRELIWSGVLEWQEKM---SDQNPKITRTLPCQvsNSVKNGEpELKAEKWPQKLIMQLMPKTLLGNIGgALLRNSRVVV 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1418360167 180 FHFTNRDCDSLKGLCRIMGNGFAGCMLF---PHISPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVSAIRQVITTRKQ 253
Cdd:pfam11232  78 FHFTPTDLEALKSLYRVMSNGFAGCVHFpgiPANPQCDIKVLMLLYSPKKNAFMGLIPNDQAAFVNRLRQVIKKQKQ 154
Med25 pfam11232
Mediator complex subunit 25 PTOV activation and synapsin 2; Mediator is a large complex of up ...
 269-414 1.06e-72

Mediator complex subunit 25 PTOV activation and synapsin 2; Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species. It is arranged into four different sections, a core, a head, a tail and a kinase-active part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA domain, an SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This family is the combined PTOV and SD2 domains. the PTOV domain being the domain through which Med25 co-operates with the histone acetyltransferase CBP, but the function of the SD2 domain is unclear.


Pssm-ID: 463243  Cd Length: 154  Bit Score: 225.30  E-value: 1.06e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418360167 269 NNKFLAWSGVMEWQEPRPEPNSRSKRWLPSHV--YVNQGE-ILRTEQWPRKLYMQLIPQQLLTTLV-PLFRNSRLVQFHF 344
Cdd:pfam11232   1 SQRELIWSGVLEWQEKMSDQNPKITRTLPCQVsnSVKNGEpELKAEKWPQKLIMQLMPKTLLGNIGgALLRNSRVVVFHF 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1418360167 345 T-KDLETLKSLCRIMDNGFAGCVHF---SYKASCEIRVLMLLYSSEKKIFIGLIPHDQGNFVNGIRRVIANQQQ 414
Cdd:pfam11232  81 TpTDLEALKSLYRVMSNGFAGCVHFpgiPANPQCDIKVLMLLYSPKKNAFMGLIPNDQAAFVNRLRQVIKKQKQ 154
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 1-156 1.88e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 46.73  E-value: 1.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418360167   1 MRSPAVPTPARGQLGVAFVLLPPHSVGAPVPATPPEvvaRASSQDSPAPERPAGPPSPHSAPARAPLPRAALEGARVFGA 80
Cdd:PRK14950  368 PAKPTAAAPSPVRPTPAPSTRPKAAAAANIPPKEPV---RETATPPPVPPRPVAPPVPHTPESAPKLTRAAIPVDEKPKY 444

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418360167  81 LGPIGPSSPGLTLGGLAVSEHRLSNkllAWSGVLEWQEKR------------RPYSDSTAKLKRTLPCQAYVNQGENLET 148
Cdd:PRK14950  445 TPPAPPKEEEKALIADGDVLEQLEA---IWKQILRDVPPRspavqallssgvRPVSVEKNTLTLSFKSKFHKDKIEEPEN 521


                  ....*...
gi 1418360167 149 DQWPQKLI 156
Cdd:PRK14950  522 RKITEELL 529
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 2-83 8.54e-04

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 41.53  E-value: 8.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418360167   2 RSPAVPTPARGQLGVAFVLLPPHSVGAPVPATPPEVVARASSQDSPAPERPAGPPSPHSAPARAPLPRA---ALEGARvf 78
Cdd:NF041121   30 TAASQPATPPPPAAPPSPPGDPPEPPAPEPAPLPAPYPGSLAPPPPPPPGPAGAAPGAALPVRVPAPPAlpnPLELAR-- 107


                  ....*
gi 1418360167  79 gALGP 83
Cdd:NF041121  108 -ALRP 111
FimV COG3170
Type IV pilus assembly protein FimV [Cell motility, Extracellular structures];
31-102 5.30e-03

Type IV pilus assembly protein FimV [Cell motility, Extracellular structures];


Pssm-ID: 442403 [Multi-domain]  Cd Length: 508  Bit Score: 39.01  E-value: 5.30e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1418360167  31 PATPPEVVARASSQDSPAPERPAGPPSPHSAPARAPLPRAAlegarvfgalGPIGPSSPGLTLGGLAVSEHR 102
Cdd:COG3170   106 PPAYAAAAAAPAAAPAPAPAAPAAAAAAADQPAAEAAPAAS----------GEYYPVRPGDTLWSIAARPVR 167
 
Name Accession Description Interval E-value
Med25 pfam11232
Mediator complex subunit 25 PTOV activation and synapsin 2; Mediator is a large complex of up ...
 104-253 3.24e-74

Mediator complex subunit 25 PTOV activation and synapsin 2; Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species. It is arranged into four different sections, a core, a head, a tail and a kinase-active part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA domain, an SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This family is the combined PTOV and SD2 domains. the PTOV domain being the domain through which Med25 co-operates with the histone acetyltransferase CBP, but the function of the SD2 domain is unclear.


Pssm-ID: 463243  Cd Length: 154  Bit Score: 229.15  E-value: 3.24e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418360167 104 SNKLLAWSGVLEWQEKRrpySDSTAKLKRTLPCQ--AYVNQGE-NLETDQWPQKLIMQLIPQQLLTTLG-PLFRNSQLAQ 179
Cdd:pfam11232   1 SQRELIWSGVLEWQEKM---SDQNPKITRTLPCQvsNSVKNGEpELKAEKWPQKLIMQLMPKTLLGNIGgALLRNSRVVV 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1418360167 180 FHFTNRDCDSLKGLCRIMGNGFAGCMLF---PHISPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVSAIRQVITTRKQ 253
Cdd:pfam11232  78 FHFTPTDLEALKSLYRVMSNGFAGCVHFpgiPANPQCDIKVLMLLYSPKKNAFMGLIPNDQAAFVNRLRQVIKKQKQ 154
Med25 pfam11232
Mediator complex subunit 25 PTOV activation and synapsin 2; Mediator is a large complex of up ...
 269-414 1.06e-72

Mediator complex subunit 25 PTOV activation and synapsin 2; Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species. It is arranged into four different sections, a core, a head, a tail and a kinase-active part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA domain, an SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This family is the combined PTOV and SD2 domains. the PTOV domain being the domain through which Med25 co-operates with the histone acetyltransferase CBP, but the function of the SD2 domain is unclear.


Pssm-ID: 463243  Cd Length: 154  Bit Score: 225.30  E-value: 1.06e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418360167 269 NNKFLAWSGVMEWQEPRPEPNSRSKRWLPSHV--YVNQGE-ILRTEQWPRKLYMQLIPQQLLTTLV-PLFRNSRLVQFHF 344
Cdd:pfam11232   1 SQRELIWSGVLEWQEKMSDQNPKITRTLPCQVsnSVKNGEpELKAEKWPQKLIMQLMPKTLLGNIGgALLRNSRVVVFHF 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1418360167 345 T-KDLETLKSLCRIMDNGFAGCVHF---SYKASCEIRVLMLLYSSEKKIFIGLIPHDQGNFVNGIRRVIANQQQ 414
Cdd:pfam11232  81 TpTDLEALKSLYRVMSNGFAGCVHFpgiPANPQCDIKVLMLLYSPKKNAFMGLIPNDQAAFVNRLRQVIKKQKQ 154
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 1-156 1.88e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 46.73  E-value: 1.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418360167   1 MRSPAVPTPARGQLGVAFVLLPPHSVGAPVPATPPEvvaRASSQDSPAPERPAGPPSPHSAPARAPLPRAALEGARVFGA 80
Cdd:PRK14950  368 PAKPTAAAPSPVRPTPAPSTRPKAAAAANIPPKEPV---RETATPPPVPPRPVAPPVPHTPESAPKLTRAAIPVDEKPKY 444

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418360167  81 LGPIGPSSPGLTLGGLAVSEHRLSNkllAWSGVLEWQEKR------------RPYSDSTAKLKRTLPCQAYVNQGENLET 148
Cdd:PRK14950  445 TPPAPPKEEEKALIADGDVLEQLEA---IWKQILRDVPPRspavqallssgvRPVSVEKNTLTLSFKSKFHKDKIEEPEN 521


                  ....*...
gi 1418360167 149 DQWPQKLI 156
Cdd:PRK14950  522 RKITEELL 529
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
22-89 4.15e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 46.02  E-value: 4.15e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1418360167  22 PPHSVGAPVPATPPEVVARASSQDSP---------APERPAGPPSPHSAPARAPLPRAALEGARVFGALGPIGPSSP 89
Cdd:PRK12323  374 PATAAAAPVAQPAPAAAAPAAAAPAPaappaapaaAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAP 450
PHA03247 PHA03247
large tegument protein UL36; Provisional
 3-89 2.57e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 2.57e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418360167    3 SPAVPTPARGQLGVAFVLLPPHSVGAPVPATPPevVARASSQDSPAPERPAGPPSPH--SAPARAPLPRAALEGARVFGA 80
Cdd:PHA03247  2716 VSATPLPPGPAAARQASPALPAAPAPPAVPAGP--ATPGGPARPARPPTTAGPPAPAppAAPAAGPPRRLTRPAVASLSE 2793


                   ....*....
gi 1418360167   81 LGPIGPSSP 89
Cdd:PHA03247  2794 SRESLPSPW 2802
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 22-90 7.42e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.90  E-value: 7.42e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1418360167  22 PPHSVGAPVPATPPEVVARASSQDSPAPERPAGPPSPHSAPARAPLPRAALEGARVFGALGPIGPSSPG 90
Cdd:PRK07764  399 PSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPA 467
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 2-83 8.54e-04

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 41.53  E-value: 8.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418360167   2 RSPAVPTPARGQLGVAFVLLPPHSVGAPVPATPPEVVARASSQDSPAPERPAGPPSPHSAPARAPLPRA---ALEGARvf 78
Cdd:NF041121   30 TAASQPATPPPPAAPPSPPGDPPEPPAPEPAPLPAPYPGSLAPPPPPPPGPAGAAPGAALPVRVPAPPAlpnPLELAR-- 107


                  ....*
gi 1418360167  79 gALGP 83
Cdd:NF041121  108 -ALRP 111
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
3-89 1.04e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.40  E-value: 1.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418360167   3 SPAVPTPARGqlgvafvllPPHSVGAPVPATPPEVVARASSQDSPAPE---------------RPAGPPSPHSAPARAPL 67
Cdd:PRK12323  393 AAAAPAPAAP---------PAAPAAAPAAAAAARAVAAAPARRSPAPEalaaarqasargpggAPAPAPAPAAAPAAAAR 463

                          90       100
                  ....*....|....*....|..
gi 1418360167  68 PRAALEGARVFGALGPIGPSSP 89
Cdd:PRK12323  464 PAAAGPRPVAAAAAAAPARAAP 485
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 2-89 1.53e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.74  E-value: 1.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418360167   2 RSPAVPTPARGQLGVAFVLLPPHSVGAPVPATPPEVVARAS-SQDSPAPERPAGPPSPHSAPARAPLPRAALEGARVFGA 80
Cdd:PRK07764  655 KHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGaAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPA 734


                  ....*....
gi 1418360167  81 LGPIGPSSP 89
Cdd:PRK07764  735 ADDPVPLPP 743
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 1-71 1.86e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.47  E-value: 1.86e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1418360167   1 MRSPAVPTPARGQLGVAFVLLPPHSVGAPVPATPPEVVARASSQDSPAPERPAGPPSPHSAPARAPLPRAA 71
Cdd:PRK14951  375 PAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAV 445
PHA03247 PHA03247
large tegument protein UL36; Provisional
 31-89 2.16e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 2.16e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1418360167   31 PATPPEVVARASSQDSPAPERPAGPPsPHSAPARAPLPRAALEGARVFGALgPIGPSSP 89
Cdd:PHA03247  2686 RAARPTVGSLTSLADPPPPPPTPEPA-PHALVSATPLPPGPAAARQASPAL-PAAPAPP 2742
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 3-124 2.36e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 2.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418360167   3 SPAVPTPARGQLGVAFVLLP-----PHSVGAPVPATPPEVVARASSQDSPAPERPAGPPS--PHSAPARAPLPRAALEGA 75
Cdd:PRK07764  404 AAPAAAPAPAAAAPAAAAAPapaaaPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSaqPAPAPAAAPEPTAAPAPA 483

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1418360167  76 RVFGALG---PIGPSSPGLTLGGLAVSEHRlsnklLAWSGVLEWQEKRRPYS 124
Cdd:PRK07764  484 PPAAPAPaaaPAAPAAPAAPAGADDAATLR-----ERWPEILAAVPKRSRKT 530
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
 28-138 2.61e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 39.93  E-value: 2.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418360167  28 APVPATPPEVVARASSQDSPAPERPAGPPSPhSAPARAPLPRAALEGARVFGALGPIGPSSPGLTLGglAVSEHRLSNKL 107
Cdd:PRK14954  381 APSPAGSPDVKKKAPEPDLPQPDRHPGPAKP-EAPGARPAELPSPASAPTPEQQPPVARSAPLPPSP--QASAPRNVASG 457

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1418360167 108 LAWSGVLEWQEKrrpYSDSTAKLKRTLPCQA 138
Cdd:PRK14954  458 KPGVDLGSWQGK---FMNFTRNGSRKQPVQA 485
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
2-91 2.77e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.24  E-value: 2.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418360167   2 RSPAVPTPARGQLGVAFVLLP--PHSVGAPVPATPPEVVARASSQDSPAPERPAGPPSPHSAPARAPLPRAALEGARVFG 79
Cdd:PRK12323  421 AAPARRSPAPEALAAARQASArgPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWE 500

                          90
                  ....*....|..
gi 1418360167  80 ALgPIGPSSPGL 91
Cdd:PRK12323  501 EL-PPEFASPAP 511
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
22-71 2.88e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 40.22  E-value: 2.88e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1418360167  22 PPHSVGAPVPATPPEVVARASSQDSPAPERPAGPPSPHSAPARAPLPRAA 71
Cdd:PRK07003  376 VAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEA 425
PHA03247 PHA03247
large tegument protein UL36; Provisional
 4-95 3.48e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 3.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418360167    4 PAVPTPARGQLGVAFVLLPPHSVGAPVPA-------------TPPEVVARASSQDS-PAPERPAGPPSPHSAPARA---- 65
Cdd:PHA03247  2742 PAVPAGPATPGGPARPARPPTTAGPPAPAppaapaagpprrlTRPAVASLSESRESlPSPWDPADPPAAVLAPAAAlppa 2821

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1418360167   66 -------PLPRAALEGArvfgALGPIGPSSPGLTLGG 95
Cdd:PHA03247  2822 aspagplPPPTSAQPTA----PPPPPGPPPPSLPLGG 2854
PHA03247 PHA03247
large tegument protein UL36; Provisional
 28-134 4.32e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.54  E-value: 4.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418360167   28 APVPATPPEVVARASSQDSPAPERPAGPPSPHSAPARAPLPRAALEGARVFGALGPIGPSSPGLTLGGLAVSEHRLSNKL 107
Cdd:PHA03247   388 ARHAATPFARGPGGDDQTRPAAPVPASVPTPAPTPVPASAPPPPATPLPSAEPGSDDGPAPPPERQPPAPATEPAPDDPD 467

                           90       100
                   ....*....|....*....|....*..
gi 1418360167  108 LAWSGVLEWQEKRRPYSDSTAKLKRTL 134
Cdd:PHA03247   468 DATRKALDALRERRPPEPPGADLAELL 494
FimV COG3170
Type IV pilus assembly protein FimV [Cell motility, Extracellular structures];
31-102 5.30e-03

Type IV pilus assembly protein FimV [Cell motility, Extracellular structures];


Pssm-ID: 442403 [Multi-domain]  Cd Length: 508  Bit Score: 39.01  E-value: 5.30e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1418360167  31 PATPPEVVARASSQDSPAPERPAGPPSPHSAPARAPLPRAAlegarvfgalGPIGPSSPGLTLGGLAVSEHR 102
Cdd:COG3170   106 PPAYAAAAAAPAAAPAPAPAAPAAAAAAADQPAAEAAPAAS----------GEYYPVRPGDTLWSIAARPVR 167
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 4-101 5.89e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.20  E-value: 5.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418360167   4 PAVPTPARGQLGVAFVLLPPHSVGAPVPATPPEVVARASSQDSPAPERPAGPPSPHSAPARAPLPRAALEGARVFGALGP 83
Cdd:PRK07764  645 PGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQA 724

                          90
                  ....*....|....*...
gi 1418360167  84 IGPSSPGLTLGGLAVSEH 101
Cdd:PRK07764  725 AQGASAPSPAADDPVPLP 742
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 3-95 7.54e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 39.00  E-value: 7.54e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418360167    3 SPAVPTPARGQLGVAFVLLPPHSVGAPVPATPPEVVARASSQDSPAPERPAGPPSPHSAPARAPLPRAALEGARVFGALG 82
Cdd:PHA03307   159 PAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSD 238

                           90
                   ....*....|...
gi 1418360167   83 PIGPSSPGLTLGG 95
Cdd:PHA03307   239 SSSSESSGCGWGP 251
PHA03378 PHA03378
EBNA-3B; Provisional
 1-68 7.92e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 38.51  E-value: 7.92e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418360167   1 MRSP-AVPTPARGQLGVAFVLLPPHsvGAPVPATPPevvarASSQDSPAP-ERPAGPPSPHSAPARAPLP 68
Cdd:PHA03378  734 ARPPaAAPGRARPPAAAPGRARPPA--AAPGRARPP-----AAAPGAPTPqPPPQAPPAPQQRPRGAPTP 796
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 3-90 8.36e-03

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 38.01  E-value: 8.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418360167   3 SPAVPTPARGQLGVAFVLLPPHSVGAP--VPATPPEVVARASSQDSPAPERPAGPPSPHSA-PARAPLPRAALEGARVFG 79
Cdd:PTZ00436  265 AKAAAPPAKAAAPPAKAAAPPAKAAAPpaKAAAAPAKAAAAPAKAAAAPAKAAAPPAKAAApPAKAATPPAKAAAPPAKA 344

                          90
                  ....*....|.
gi 1418360167  80 ALGPIGPSSPG 90
Cdd:PTZ00436  345 AAAPVGKKAGG 355
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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