N-acetylglucosamine-1-phosphotransferase subunits alpha/beta isoform 2 [Mus musculus]
List of domain hits
Name | Accession | Description | Interval | E-value | |||
Stealth_CR2 | pfam11380 | Stealth protein CR2, conserved region 2; Stealth_CR2 is the second of several highly conserved ... |
276-383 | 3.15e-64 | |||
Stealth protein CR2, conserved region 2; Stealth_CR2 is the second of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR2 carries a well-conserved NDD sequence-motif. The domain is found in tandem with CR1, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system. : Pssm-ID: 463267 Cd Length: 108 Bit Score: 212.33 E-value: 3.15e-64
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GlcNAc-1_reg | pfam18440 | Putative GlcNAc-1 phosphotransferase regulatory domain; The Golgi enzyme UDP-GlcNAc-lysosomal ... |
173-259 | 1.35e-44 | |||
Putative GlcNAc-1 phosphotransferase regulatory domain; The Golgi enzyme UDP-GlcNAc-lysosomal enzyme N-acetylglucosamine-1-phosphotransferase (GlcNAc-1-phosphotransferase), an alpha2beta2gamma2 hexamer, mediates the initial step in the addition of the mannose 6-phosphate targeting signal on newly synthesized lysosomal enzymes. GNPTAB encodes the alpha and beta subunits of GlcNAc-1-phosphotransferase, and mutations in this gene cause the lysosomal storage disorders mucolipidosis II and III alpha-beta The alpha-beta subunits contain three identifiable domains separated by so-called spacer regions. This domain is part of the first spacer region, Spacer-1. Studies indicate that GlcNAc-1 lacking spacer-1 exhibits enhanced phosphorylation of several non-lysosomal glycoproteins, while the phosphorylation of lysosomal acid hydrolases is not altered. In view of these effects on the maturation and function of GlcNAc-1, it is suggested to rename 'spacer-1' the 'regulatory-1' domain. : Pssm-ID: 408237 Cd Length: 88 Bit Score: 155.90 E-value: 1.35e-44
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RRM1_GNPTAB | cd21599 | RNA recognition motif 1 (RRM1) found in N-acetylglucosamine-1-phosphotransferase subunits ... |
91-179 | 1.37e-34 | |||
RNA recognition motif 1 (RRM1) found in N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (GNPTAB) and similar proteins; GNPTAB, also termed GlcNAc-1-phosphotransferase subunits alpha/beta, or stealth protein GNPTAB, or UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta, catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment. The model corresponds to the RNA recognition motif 1 (RRM1) of GNPTAB. Its functional significance remains to be investigated. : Pssm-ID: 410178 [Multi-domain] Cd Length: 90 Bit Score: 127.41 E-value: 1.37e-34
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DMAP_binding | pfam06464 | DMAP1-binding Domain; This domain binds DMAP1, a transcriptional co-repressor. |
653-765 | 3.13e-24 | |||
DMAP1-binding Domain; This domain binds DMAP1, a transcriptional co-repressor. : Pssm-ID: 368923 [Multi-domain] Cd Length: 104 Bit Score: 98.26 E-value: 3.13e-24
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Stealth_CR4 | pfam17103 | Stealth protein CR4, conserved region 4; Stealth_CR4 is the fourth highly conserved region on ... |
1071-1127 | 1.50e-23 | |||
Stealth protein CR4, conserved region 4; Stealth_CR4 is the fourth highly conserved region on stealth proteins in metazoa and bacteria. There are four CR regions on mammalian members. CR4 carries a well-conserved CLND sequence-motif. The domain is found in tandem with CR1, CR2 and CR3 on both potential metazoan hosts and on pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains also appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system. : Pssm-ID: 465348 Cd Length: 55 Bit Score: 94.58 E-value: 1.50e-23
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Stealth_CR3 | pfam17102 | Stealth protein CR3, conserved region 3; Stealth_CR3 is the third of several highly conserved ... |
888-936 | 7.50e-20 | |||
Stealth protein CR3, conserved region 3; Stealth_CR3 is the third of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. The domain is found in tandem with CR1, CR2 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system. : Pssm-ID: 465347 Cd Length: 49 Bit Score: 83.72 E-value: 7.50e-20
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Notch | pfam00066 | LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ... |
390-423 | 3.42e-13 | |||
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase. : Pssm-ID: 459658 Cd Length: 35 Bit Score: 64.47 E-value: 3.42e-13
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Stealth_CR1 | pfam17101 | Stealth protein CR1, conserved region 1; Stealth_C1 is the first of several highly conserved ... |
27-55 | 1.28e-08 | |||
Stealth protein CR1, conserved region 1; Stealth_C1 is the first of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR1 carries a well-conserved IDVVYT sequence-motif. The domain is found in tandem with CR2, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system. : Pssm-ID: 465346 Cd Length: 29 Bit Score: 51.32 E-value: 1.28e-08
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Notch | pfam00066 | LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ... |
457-489 | 4.07e-07 | |||
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase. : Pssm-ID: 459658 Cd Length: 35 Bit Score: 47.14 E-value: 4.07e-07
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Name | Accession | Description | Interval | E-value | |||
Stealth_CR2 | pfam11380 | Stealth protein CR2, conserved region 2; Stealth_CR2 is the second of several highly conserved ... |
276-383 | 3.15e-64 | |||
Stealth protein CR2, conserved region 2; Stealth_CR2 is the second of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR2 carries a well-conserved NDD sequence-motif. The domain is found in tandem with CR1, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system. Pssm-ID: 463267 Cd Length: 108 Bit Score: 212.33 E-value: 3.15e-64
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GlcNAc-1_reg | pfam18440 | Putative GlcNAc-1 phosphotransferase regulatory domain; The Golgi enzyme UDP-GlcNAc-lysosomal ... |
173-259 | 1.35e-44 | |||
Putative GlcNAc-1 phosphotransferase regulatory domain; The Golgi enzyme UDP-GlcNAc-lysosomal enzyme N-acetylglucosamine-1-phosphotransferase (GlcNAc-1-phosphotransferase), an alpha2beta2gamma2 hexamer, mediates the initial step in the addition of the mannose 6-phosphate targeting signal on newly synthesized lysosomal enzymes. GNPTAB encodes the alpha and beta subunits of GlcNAc-1-phosphotransferase, and mutations in this gene cause the lysosomal storage disorders mucolipidosis II and III alpha-beta The alpha-beta subunits contain three identifiable domains separated by so-called spacer regions. This domain is part of the first spacer region, Spacer-1. Studies indicate that GlcNAc-1 lacking spacer-1 exhibits enhanced phosphorylation of several non-lysosomal glycoproteins, while the phosphorylation of lysosomal acid hydrolases is not altered. In view of these effects on the maturation and function of GlcNAc-1, it is suggested to rename 'spacer-1' the 'regulatory-1' domain. Pssm-ID: 408237 Cd Length: 88 Bit Score: 155.90 E-value: 1.35e-44
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RRM1_GNPTAB | cd21599 | RNA recognition motif 1 (RRM1) found in N-acetylglucosamine-1-phosphotransferase subunits ... |
91-179 | 1.37e-34 | |||
RNA recognition motif 1 (RRM1) found in N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (GNPTAB) and similar proteins; GNPTAB, also termed GlcNAc-1-phosphotransferase subunits alpha/beta, or stealth protein GNPTAB, or UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta, catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment. The model corresponds to the RNA recognition motif 1 (RRM1) of GNPTAB. Its functional significance remains to be investigated. Pssm-ID: 410178 [Multi-domain] Cd Length: 90 Bit Score: 127.41 E-value: 1.37e-34
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RRM2_GNPTAB | cd21600 | RNA recognition motif 2 (RRM2) found in N-acetylglucosamine-1-phosphotransferase subunits ... |
181-259 | 2.32e-27 | |||
RNA recognition motif 2 (RRM2) found in N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (GNPTAB) and similar proteins; GNPTAB, also termed GlcNAc-1-phosphotransferase subunits alpha/beta, or stealth protein GNPTAB, or UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta, catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment. The model corresponds to the RNA recognition motif 2 (RRM2) of GNPTAB. Its functional significance remains to be investigated. Pssm-ID: 410179 Cd Length: 77 Bit Score: 106.16 E-value: 2.32e-27
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DMAP_binding | pfam06464 | DMAP1-binding Domain; This domain binds DMAP1, a transcriptional co-repressor. |
653-765 | 3.13e-24 | |||
DMAP1-binding Domain; This domain binds DMAP1, a transcriptional co-repressor. Pssm-ID: 368923 [Multi-domain] Cd Length: 104 Bit Score: 98.26 E-value: 3.13e-24
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Stealth_CR4 | pfam17103 | Stealth protein CR4, conserved region 4; Stealth_CR4 is the fourth highly conserved region on ... |
1071-1127 | 1.50e-23 | |||
Stealth protein CR4, conserved region 4; Stealth_CR4 is the fourth highly conserved region on stealth proteins in metazoa and bacteria. There are four CR regions on mammalian members. CR4 carries a well-conserved CLND sequence-motif. The domain is found in tandem with CR1, CR2 and CR3 on both potential metazoan hosts and on pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains also appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system. Pssm-ID: 465348 Cd Length: 55 Bit Score: 94.58 E-value: 1.50e-23
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Stealth_CR3 | pfam17102 | Stealth protein CR3, conserved region 3; Stealth_CR3 is the third of several highly conserved ... |
888-936 | 7.50e-20 | |||
Stealth protein CR3, conserved region 3; Stealth_CR3 is the third of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. The domain is found in tandem with CR1, CR2 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system. Pssm-ID: 465347 Cd Length: 49 Bit Score: 83.72 E-value: 7.50e-20
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Notch | pfam00066 | LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ... |
390-423 | 3.42e-13 | |||
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase. Pssm-ID: 459658 Cd Length: 35 Bit Score: 64.47 E-value: 3.42e-13
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NL | smart00004 | Domain found in Notch and Lin-12; The Notch protein is essential for the proper ... |
388-422 | 1.01e-09 | |||
Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains. Pssm-ID: 197463 Cd Length: 38 Bit Score: 54.64 E-value: 1.01e-09
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Stealth_CR1 | pfam17101 | Stealth protein CR1, conserved region 1; Stealth_C1 is the first of several highly conserved ... |
27-55 | 1.28e-08 | |||
Stealth protein CR1, conserved region 1; Stealth_C1 is the first of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR1 carries a well-conserved IDVVYT sequence-motif. The domain is found in tandem with CR2, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system. Pssm-ID: 465346 Cd Length: 29 Bit Score: 51.32 E-value: 1.28e-08
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Notch | pfam00066 | LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ... |
457-489 | 4.07e-07 | |||
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase. Pssm-ID: 459658 Cd Length: 35 Bit Score: 47.14 E-value: 4.07e-07
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NL | smart00004 | Domain found in Notch and Lin-12; The Notch protein is essential for the proper ... |
469-489 | 2.08e-04 | |||
Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains. Pssm-ID: 197463 Cd Length: 38 Bit Score: 39.62 E-value: 2.08e-04
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Name | Accession | Description | Interval | E-value | |||
Stealth_CR2 | pfam11380 | Stealth protein CR2, conserved region 2; Stealth_CR2 is the second of several highly conserved ... |
276-383 | 3.15e-64 | |||
Stealth protein CR2, conserved region 2; Stealth_CR2 is the second of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR2 carries a well-conserved NDD sequence-motif. The domain is found in tandem with CR1, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system. Pssm-ID: 463267 Cd Length: 108 Bit Score: 212.33 E-value: 3.15e-64
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GlcNAc-1_reg | pfam18440 | Putative GlcNAc-1 phosphotransferase regulatory domain; The Golgi enzyme UDP-GlcNAc-lysosomal ... |
173-259 | 1.35e-44 | |||
Putative GlcNAc-1 phosphotransferase regulatory domain; The Golgi enzyme UDP-GlcNAc-lysosomal enzyme N-acetylglucosamine-1-phosphotransferase (GlcNAc-1-phosphotransferase), an alpha2beta2gamma2 hexamer, mediates the initial step in the addition of the mannose 6-phosphate targeting signal on newly synthesized lysosomal enzymes. GNPTAB encodes the alpha and beta subunits of GlcNAc-1-phosphotransferase, and mutations in this gene cause the lysosomal storage disorders mucolipidosis II and III alpha-beta The alpha-beta subunits contain three identifiable domains separated by so-called spacer regions. This domain is part of the first spacer region, Spacer-1. Studies indicate that GlcNAc-1 lacking spacer-1 exhibits enhanced phosphorylation of several non-lysosomal glycoproteins, while the phosphorylation of lysosomal acid hydrolases is not altered. In view of these effects on the maturation and function of GlcNAc-1, it is suggested to rename 'spacer-1' the 'regulatory-1' domain. Pssm-ID: 408237 Cd Length: 88 Bit Score: 155.90 E-value: 1.35e-44
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RRM1_GNPTAB | cd21599 | RNA recognition motif 1 (RRM1) found in N-acetylglucosamine-1-phosphotransferase subunits ... |
91-179 | 1.37e-34 | |||
RNA recognition motif 1 (RRM1) found in N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (GNPTAB) and similar proteins; GNPTAB, also termed GlcNAc-1-phosphotransferase subunits alpha/beta, or stealth protein GNPTAB, or UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta, catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment. The model corresponds to the RNA recognition motif 1 (RRM1) of GNPTAB. Its functional significance remains to be investigated. Pssm-ID: 410178 [Multi-domain] Cd Length: 90 Bit Score: 127.41 E-value: 1.37e-34
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RRM2_GNPTAB | cd21600 | RNA recognition motif 2 (RRM2) found in N-acetylglucosamine-1-phosphotransferase subunits ... |
181-259 | 2.32e-27 | |||
RNA recognition motif 2 (RRM2) found in N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (GNPTAB) and similar proteins; GNPTAB, also termed GlcNAc-1-phosphotransferase subunits alpha/beta, or stealth protein GNPTAB, or UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta, catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment. The model corresponds to the RNA recognition motif 2 (RRM2) of GNPTAB. Its functional significance remains to be investigated. Pssm-ID: 410179 Cd Length: 77 Bit Score: 106.16 E-value: 2.32e-27
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DMAP_binding | pfam06464 | DMAP1-binding Domain; This domain binds DMAP1, a transcriptional co-repressor. |
653-765 | 3.13e-24 | |||
DMAP1-binding Domain; This domain binds DMAP1, a transcriptional co-repressor. Pssm-ID: 368923 [Multi-domain] Cd Length: 104 Bit Score: 98.26 E-value: 3.13e-24
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Stealth_CR4 | pfam17103 | Stealth protein CR4, conserved region 4; Stealth_CR4 is the fourth highly conserved region on ... |
1071-1127 | 1.50e-23 | |||
Stealth protein CR4, conserved region 4; Stealth_CR4 is the fourth highly conserved region on stealth proteins in metazoa and bacteria. There are four CR regions on mammalian members. CR4 carries a well-conserved CLND sequence-motif. The domain is found in tandem with CR1, CR2 and CR3 on both potential metazoan hosts and on pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains also appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system. Pssm-ID: 465348 Cd Length: 55 Bit Score: 94.58 E-value: 1.50e-23
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Stealth_CR3 | pfam17102 | Stealth protein CR3, conserved region 3; Stealth_CR3 is the third of several highly conserved ... |
888-936 | 7.50e-20 | |||
Stealth protein CR3, conserved region 3; Stealth_CR3 is the third of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. The domain is found in tandem with CR1, CR2 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system. Pssm-ID: 465347 Cd Length: 49 Bit Score: 83.72 E-value: 7.50e-20
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Notch | pfam00066 | LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ... |
390-423 | 3.42e-13 | |||
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase. Pssm-ID: 459658 Cd Length: 35 Bit Score: 64.47 E-value: 3.42e-13
|
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NL | smart00004 | Domain found in Notch and Lin-12; The Notch protein is essential for the proper ... |
388-422 | 1.01e-09 | |||
Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains. Pssm-ID: 197463 Cd Length: 38 Bit Score: 54.64 E-value: 1.01e-09
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Stealth_CR1 | pfam17101 | Stealth protein CR1, conserved region 1; Stealth_C1 is the first of several highly conserved ... |
27-55 | 1.28e-08 | |||
Stealth protein CR1, conserved region 1; Stealth_C1 is the first of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR1 carries a well-conserved IDVVYT sequence-motif. The domain is found in tandem with CR2, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system. Pssm-ID: 465346 Cd Length: 29 Bit Score: 51.32 E-value: 1.28e-08
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Notch | pfam00066 | LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ... |
457-489 | 4.07e-07 | |||
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase. Pssm-ID: 459658 Cd Length: 35 Bit Score: 47.14 E-value: 4.07e-07
|
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NL | smart00004 | Domain found in Notch and Lin-12; The Notch protein is essential for the proper ... |
469-489 | 2.08e-04 | |||
Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains. Pssm-ID: 197463 Cd Length: 38 Bit Score: 39.62 E-value: 2.08e-04
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Blast search parameters | ||||
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