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Conserved domains on  [gi|1401585312|ref|NP_001351225|]
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transportin-1 isoform 5 [Homo sapiens]

Protein Classification

importin-beta N-terminal domain-containing protein( domain architecture ID 10510703)

importin-beta N-terminal domain-containing protein similar to Homo sapiens transportin-1 isoform 5

CATH:  1.25.10.10
Gene Ontology:  GO:0031267|GO:0006886
SCOP:  4001298

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IBN_N pfam03810
Importin-beta N-terminal domain;
34-101 3.56e-11

Importin-beta N-terminal domain;


:

Pssm-ID: 397745 [Multi-domain]  Cd Length: 72  Bit Score: 56.48  E-value: 3.56e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1401585312  34 QQKLEQLNQYPDFNNYLIFVLTKLKSeDEPTRSLSGLILKNNVKAHFQ----NFPNGVTDFIKSECLNNIGD 101
Cdd:pfam03810   2 EKQLEQFEKSPGFWSKLLQILSNSEN-PLEVRQLAALYLKNLITRHWEeeknSLPPEEKEQIKNNLLNLLGS 72
CSE1 super family cl35039
CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]; ...
 23-188 8.53e-10

CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5657:

Pssm-ID: 227944 [Multi-domain]  Cd Length: 947  Bit Score: 57.51  E-value: 8.53e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585312  23 QSPDTTIQRTVQQKLEQLNQYPDFNnYLIFVLTKLKSEDEPTRSLSGLILKNNVKAHF-QNFPNGV----TDFIKSECLN 97
Cdd:COG5657    14 QSPDPPSVKCAEERLRQWEKQHGFA-LKLLSINLSAFNSMSLRWAALIQFKNYIDKHWrEENGNSIlpdeNVLIRDELFS 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585312  98 NIGDSSPLIRATVGILITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPLNIMIP 177
Cdd:COG5657    93 LIISSSNQLQIQNALAVSRIARLDFPDEWPTLVPDLLSLLSEKDMVTNENSLRVLHHIFKRLRRLFRSDALFLEIAPVLL 172

                         170
                  ....*....|.
gi 1401585312 178 KFLQFFKHSSP 188
Cdd:COG5657   173 SILCPFLFSSA 183
 
Name Accession Description Interval E-value
IBN_N pfam03810
Importin-beta N-terminal domain;
34-101 3.56e-11

Importin-beta N-terminal domain;


Pssm-ID: 397745 [Multi-domain]  Cd Length: 72  Bit Score: 56.48  E-value: 3.56e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1401585312  34 QQKLEQLNQYPDFNNYLIFVLTKLKSeDEPTRSLSGLILKNNVKAHFQ----NFPNGVTDFIKSECLNNIGD 101
Cdd:pfam03810   2 EKQLEQFEKSPGFWSKLLQILSNSEN-PLEVRQLAALYLKNLITRHWEeeknSLPPEEKEQIKNNLLNLLGS 72
CSE1 COG5657
CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]; ...
 23-188 8.53e-10

CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning];


Pssm-ID: 227944 [Multi-domain]  Cd Length: 947  Bit Score: 57.51  E-value: 8.53e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585312  23 QSPDTTIQRTVQQKLEQLNQYPDFNnYLIFVLTKLKSEDEPTRSLSGLILKNNVKAHF-QNFPNGV----TDFIKSECLN 97
Cdd:COG5657    14 QSPDPPSVKCAEERLRQWEKQHGFA-LKLLSINLSAFNSMSLRWAALIQFKNYIDKHWrEENGNSIlpdeNVLIRDELFS 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585312  98 NIGDSSPLIRATVGILITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPLNIMIP 177
Cdd:COG5657    93 LIISSSNQLQIQNALAVSRIARLDFPDEWPTLVPDLLSLLSEKDMVTNENSLRVLHHIFKRLRRLFRSDALFLEIAPVLL 172

                         170
                  ....*....|.
gi 1401585312 178 KFLQFFKHSSP 188
Cdd:COG5657   173 SILCPFLFSSA 183
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
 34-101 4.40e-08

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 48.01  E-value: 4.40e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1401585312   34 QQKLEQLNQYPDFNNYLIFVLTKlkSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGD 101
Cdd:smart00913   2 EKQLEQFQKSPGFWLLLLEILAN--SEDQYVRQLAAITLKNKITRRWSSLPEEEKEEIKNSLLELLLS 67
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 99-166 4.30e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 35.01  E-value: 4.30e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1401585312  99 IGDSSPLIRATVgilITTIASKGElqnwPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSA-----EILDSD 166
Cdd:pfam13646   9 LRDPDPEVRAAA---IRALGRIGD----PEAVPALLELLKDEDPAVRRAAAEALGKIGDPEAlpallELLRDD 74
 
Name Accession Description Interval E-value
IBN_N pfam03810
Importin-beta N-terminal domain;
34-101 3.56e-11

Importin-beta N-terminal domain;


Pssm-ID: 397745 [Multi-domain]  Cd Length: 72  Bit Score: 56.48  E-value: 3.56e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1401585312  34 QQKLEQLNQYPDFNNYLIFVLTKLKSeDEPTRSLSGLILKNNVKAHFQ----NFPNGVTDFIKSECLNNIGD 101
Cdd:pfam03810   2 EKQLEQFEKSPGFWSKLLQILSNSEN-PLEVRQLAALYLKNLITRHWEeeknSLPPEEKEQIKNNLLNLLGS 72
CSE1 COG5657
CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]; ...
 23-188 8.53e-10

CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning];


Pssm-ID: 227944 [Multi-domain]  Cd Length: 947  Bit Score: 57.51  E-value: 8.53e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585312  23 QSPDTTIQRTVQQKLEQLNQYPDFNnYLIFVLTKLKSEDEPTRSLSGLILKNNVKAHF-QNFPNGV----TDFIKSECLN 97
Cdd:COG5657    14 QSPDPPSVKCAEERLRQWEKQHGFA-LKLLSINLSAFNSMSLRWAALIQFKNYIDKHWrEENGNSIlpdeNVLIRDELFS 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585312  98 NIGDSSPLIRATVGILITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPLNIMIP 177
Cdd:COG5657    93 LIISSSNQLQIQNALAVSRIARLDFPDEWPTLVPDLLSLLSEKDMVTNENSLRVLHHIFKRLRRLFRSDALFLEIAPVLL 172

                         170
                  ....*....|.
gi 1401585312 178 KFLQFFKHSSP 188
Cdd:COG5657   173 SILCPFLFSSA 183
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
 34-101 4.40e-08

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 48.01  E-value: 4.40e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1401585312   34 QQKLEQLNQYPDFNNYLIFVLTKlkSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGD 101
Cdd:smart00913   2 EKQLEQFQKSPGFWLLLLEILAN--SEDQYVRQLAAITLKNKITRRWSSLPEEEKEEIKNSLLELLLS 67
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
24-160 3.30e-06

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 46.86  E-value: 3.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585312  24 SPDTTIQRTVQQKLEQLnQYPDFNNY---LIFVLTKLKSEDEpTRSLSGLILKNNVKAH-----------FQNFPNGVTD 89
Cdd:COG5215    16 SPDPNARLRAEAQLLEL-QSGDFEQFislLVQVLCDLNSNDQ-LRMVAGLILKNSLHANdpelqkgcsqrWLGMRHESKE 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1401585312  90 FIKSECLNNIGDSSPLIRATVGILITTIASKgELQN--WPDLLPKLCSLL-DSEDYNTCEGAFGALQKICEDSA 160
Cdd:COG5215    94 QVKGMALRALKSPEPRFCTMAAQLLAAIARM-ELPNslWPGLMEEMVRNVgDEQPVSGKCESLGICGYHCESEA 166
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 99-166 4.30e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 35.01  E-value: 4.30e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1401585312  99 IGDSSPLIRATVgilITTIASKGElqnwPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSA-----EILDSD 166
Cdd:pfam13646   9 LRDPDPEVRAAA---IRALGRIGD----PEAVPALLELLKDEDPAVRRAAAEALGKIGDPEAlpallELLRDD 74
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 130-156 8.79e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 32.81  E-value: 8.79e-03
                          10        20
                  ....*....|....*....|....*..
gi 1401585312 130 LPKLCSLLDSEDYNTCEGAFGALQKIC 156
Cdd:pfam00514  14 VPPLVRLLSSPDEEVQEEAAWALSNLA 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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