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Conserved domains on  [gi|1394533258|ref|NP_001350722|]
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peptidyl-prolyl cis-trans isomerase FKBP14 isoform 3 [Mus musculus]

Protein Classification

EF-hand domain-containing protein( domain architecture ID 1000101)

EF-hand (EFh) domain-containing protein may be involved in binding intracellular calcium and in calcium signal transduction

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FRQ1 super family cl34916
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
25-114 1.98e-05

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG5126:

Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 40.93  E-value: 1.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533258  25 GNGKIPPESTLIFNIDLLEIRNGPRSHESFQEMDLNDDWRLSKHEVKVYLqkefEKHGAvvneshHDALVEDIFDKEDED 104
Cdd:COG5126    46 GDGRISREEFVAGMESLFEATVEPFARAAFDLLDTDGDGKISADEFRRLL----TALGV------SEEEADELFARLDTD 115

                          90
                  ....*....|
gi 1394533258 105 KDGFISAREF 114
Cdd:COG5126   116 GDGKISFEEF 125
 
Name Accession Description Interval E-value
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
25-114 1.98e-05

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 40.93  E-value: 1.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533258  25 GNGKIPPESTLIFNIDLLEIRNGPRSHESFQEMDLNDDWRLSKHEVKVYLqkefEKHGAvvneshHDALVEDIFDKEDED 104
Cdd:COG5126    46 GDGRISREEFVAGMESLFEATVEPFARAAFDLLDTDGDGKISADEFRRLL----TALGV------SEEEADELFARLDTD 115

                          90
                  ....*....|
gi 1394533258 105 KDGFISAREF 114
Cdd:COG5126   116 GDGKISFEEF 125
EF-hand_7 pfam13499
EF-hand domain pair;
51-114 4.41e-05

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 38.77  E-value: 4.41e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1394533258  51 HESFQEMDLNDDWRLSKHEVKVYLQKEFEkhgavvNESHHDALVEDIFDKEDEDKDGFISAREF 114
Cdd:pfam13499   5 KEAFKLLDSDGDGYLDVEELKKLLRKLEE------GEPLSDEEVEELFKEFDLDKDGRISFEEF 62
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 52-114 8.40e-04

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 35.22  E-value: 8.40e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1394533258  52 ESFQEMDLNDDWRLSKHEVKVYLQKEFEKHGavvneshhDALVEDIFDKEDEDKDGFISAREF 114
Cdd:cd00051     4 EAFRLFDKDGDGTISADELKAALKSLGEGLS--------EEEIDEMIREVDKDGDGKIDFEEF 58
 
Name Accession Description Interval E-value
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
25-114 1.98e-05

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 40.93  E-value: 1.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533258  25 GNGKIPPESTLIFNIDLLEIRNGPRSHESFQEMDLNDDWRLSKHEVKVYLqkefEKHGAvvneshHDALVEDIFDKEDED 104
Cdd:COG5126    46 GDGRISREEFVAGMESLFEATVEPFARAAFDLLDTDGDGKISADEFRRLL----TALGV------SEEEADELFARLDTD 115

                          90
                  ....*....|
gi 1394533258 105 KDGFISAREF 114
Cdd:COG5126   116 GDGKISFEEF 125
EF-hand_7 pfam13499
EF-hand domain pair;
51-114 4.41e-05

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 38.77  E-value: 4.41e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1394533258  51 HESFQEMDLNDDWRLSKHEVKVYLQKEFEkhgavvNESHHDALVEDIFDKEDEDKDGFISAREF 114
Cdd:pfam13499   5 KEAFKLLDSDGDGYLDVEELKKLLRKLEE------GEPLSDEEVEELFKEFDLDKDGRISFEEF 62
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
54-115 1.17e-04

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 39.00  E-value: 1.17e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1394533258  54 FQEMDLNDDWRLSKhevkvylqKEFEKHGAVVNESHHDALVEDIFDKEDEDKDGFISAREFT 115
Cdd:COG5126    39 FSEADTDGDGRISR--------EEFVAGMESLFEATVEPFARAAFDLLDTDGDGKISADEFR 92
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 52-114 8.40e-04

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 35.22  E-value: 8.40e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1394533258  52 ESFQEMDLNDDWRLSKHEVKVYLQKEFEKHGavvneshhDALVEDIFDKEDEDKDGFISAREF 114
Cdd:cd00051     4 EAFRLFDKDGDGTISADELKAALKSLGEGLS--------EEEIDEMIREVDKDGDGKIDFEEF 58
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 26-44 1.69e-03

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 35.16  E-value: 1.69e-03
                          10
                  ....*....|....*....
gi 1394533258  26 NGKIPPESTLIFNIDLLEI 44
Cdd:COG0545    86 GGVIPPNSTLVFEVELLDV 104
EFh_CREC_Calumenin_like cd16226
EF-hand, calcium binding motif, found in calumenin, reticulocalbin-1 (RCN-1), reticulocalbin-3 ...
 49-114 4.66e-03

EF-hand, calcium binding motif, found in calumenin, reticulocalbin-1 (RCN-1), reticulocalbin-3 (RCN-3), and similar proteins; The family corresponds to a group of six EF-hand Ca2+-binding proteins, including calumenin (also known as crocalbin or CBP-50), reticulocalbin-1 (RCN-1), reticulocalbin-3 (RCN-3), and similar proteins. Calumenin is an endo/sarcoplasmic reticulum (ER/SR) resident low-affinity Ca2+-binding protein that contains six EF-hand domains and a C-terminal SR retention signal His-Asp-Glu-Phe (HDEF) tetrapeptide. It functions as a novel regulator of SERCA2, and its expressional changes are tightly coupled with Ca2+-cycling of cardiomyocytes. It is also broadly involved in haemostasis and in the pathophysiology of thrombosis. Moreover, the extracellular calumenin acts as a suppressor of cell migration and tumor metastasis. RCN-1 is an endoplasmic reticulum resident Ca2+-binding protein with a carboxyl-terminal His-Asp-Glu-Leu (HDEL) tetrapeptide signal. It acts as a potential negative regulator of B-RAF activation and can negatively modulate cardiomyocyte hypertrophy by inhibition of the mitogen-activated protein kinase signalling cascade. It also plays a key role in the development of doxorubicin-associated resistance. RCN-3 is a putative six EF-hand Ca2+-binding protein that contains five RXXR (X is any amino acid) motifs and a C-terminal ER retrieval signal HDEL tetrapeptide. The RXXR motif represents the target sequence of subtilisin-like proprotein convertases (SPCs). RCN-3 is specifically bound to the paired basic amino-acid-cleaving enzyme-4 (PACE4) precursor protein and plays an important role in the biosynthesis of PACE4.


Pssm-ID: 320024 [Multi-domain]  Cd Length: 264  Bit Score: 35.25  E-value: 4.66e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1394533258  49 RSHESFQEMDLNDDWRLSKHEVKVYLQKEFEKHgavvnesHHDALVEDIFDKEDEDKDGFISAREF 114
Cdd:cd16226   120 RDERRWKAADQDGDGKLTKEEFTAFLHPEEFPH-------MRDIVVQETLEDIDKNKDGFISLEEY 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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