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Conserved domains on  [gi|1393170012|ref|NP_001350666|]
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large ribosomal subunit protein uL30 isoform 2 [Homo sapiens]

Protein Classification

uL30 family ribosomal protein( domain architecture ID 11492225)

uL30 family ribosomal protein binds to G-rich structures in 28S rRNA and in mRNAs, plays a regulatory role in the translation apparatus and inhibits cell-free translation of mRNAs

Gene Ontology:  GO:0003735|GO:0003723
PubMed:  24524803

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
uL30_euk TIGR01310
60S ribosomal protein uL30, eukaryotic form; This model describes the eukaryotic 60S ...
 3-208 1.86e-107

60S ribosomal protein uL30, eukaryotic form; This model describes the eukaryotic 60S (cytosolic) ribosomal protein uL30 (previously L7) and paralogs that may or may not also be uL30. Human, Drosophila, and Arabidopsis all have both a typical L7 and an L7-related paralog. This family is designated subfamily rather than equivalog to reflect these uncharacterized paralogs. Members of this family average ~ 250 residues in length, somewhat longer than the archaeal L30P/L7E homolog (~ 155 residues) and much longer than the related bacterial/organellar form (~ 60 residues).


:

Pssm-ID: 273548 [Multi-domain]  Cd Length: 235  Bit Score: 308.14  E-value: 1.86e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393170012   3 RKARRKLIYEKAKHYHKEYRQMYRTEIRMARMARKAGNFYVPAEPKLAFVIRIRGINGVSPKVRKVLQLLRLRQIFNGTF 82
Cdd:TIGR01310  28 NKKKRKDYFKRAESFVKEYRKAERKIIRLKRLAKKPGKFYVPAEHKLVFVIRIKGINGIPPKPRKVLRLLRLKQVHNGVF 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393170012  83 VKLNKASINMLRIVEPYIAWGYPNLKSVNELIYKRGYGKINKKRIALTDNALIARSLGKYGIICMEDLIHEIYTVGKRFK 162
Cdd:TIGR01310 108 VKVNKATLEMLRIVEPYVAYGYPNLKSVRELIYKRGFAKINGQRVPLTDNAIIEQHLGKYGIICIEDLIHEIYTVGPHFK 187

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1393170012 163 EANNFLWPFKLSSPRGG--MKKKTTHFVEGGDAGNREDQINRLIRRMN 208
Cdd:TIGR01310 188 EVNNFLWPFKLSSPVKGfgKRKKVKHFIEGGDFGNREDHINELIKKMN 235
 
Name Accession Description Interval E-value
uL30_euk TIGR01310
60S ribosomal protein uL30, eukaryotic form; This model describes the eukaryotic 60S ...
 3-208 1.86e-107

60S ribosomal protein uL30, eukaryotic form; This model describes the eukaryotic 60S (cytosolic) ribosomal protein uL30 (previously L7) and paralogs that may or may not also be uL30. Human, Drosophila, and Arabidopsis all have both a typical L7 and an L7-related paralog. This family is designated subfamily rather than equivalog to reflect these uncharacterized paralogs. Members of this family average ~ 250 residues in length, somewhat longer than the archaeal L30P/L7E homolog (~ 155 residues) and much longer than the related bacterial/organellar form (~ 60 residues).


Pssm-ID: 273548 [Multi-domain]  Cd Length: 235  Bit Score: 308.14  E-value: 1.86e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393170012   3 RKARRKLIYEKAKHYHKEYRQMYRTEIRMARMARKAGNFYVPAEPKLAFVIRIRGINGVSPKVRKVLQLLRLRQIFNGTF 82
Cdd:TIGR01310  28 NKKKRKDYFKRAESFVKEYRKAERKIIRLKRLAKKPGKFYVPAEHKLVFVIRIKGINGIPPKPRKVLRLLRLKQVHNGVF 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393170012  83 VKLNKASINMLRIVEPYIAWGYPNLKSVNELIYKRGYGKINKKRIALTDNALIARSLGKYGIICMEDLIHEIYTVGKRFK 162
Cdd:TIGR01310 108 VKVNKATLEMLRIVEPYVAYGYPNLKSVRELIYKRGFAKINGQRVPLTDNAIIEQHLGKYGIICIEDLIHEIYTVGPHFK 187

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1393170012 163 EANNFLWPFKLSSPRGG--MKKKTTHFVEGGDAGNREDQINRLIRRMN 208
Cdd:TIGR01310 188 EVNNFLWPFKLSSPVKGfgKRKKVKHFIEGGDFGNREDHINELIKKMN 235
Ribosomal_L7_archeal_euk cd01657
Ribosomal protein L7, which is found in archaea and eukaryotes but not in prokaryotes, binds ...
 49-208 1.73e-91

Ribosomal protein L7, which is found in archaea and eukaryotes but not in prokaryotes, binds domain II of the 23S rRNA as well as the 5S rRNA and is one of five ribosomal proteins that mediate the interactions 5S rRNA makes with the ribosome. The eukaryotic L7 members have an N-terminal extension not found in the archeal L7 orthologs. L7 is closely related to the ribosomal L30 protein found in eukaryotes and prokaryotes.


Pssm-ID: 100099  Cd Length: 159  Bit Score: 264.77  E-value: 1.73e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393170012  49 LAFVIRIRGINGVSPKVRKVLQLLRLRQIFNGTFVKLNKASINMLRIVEPYIAWGYPNLKSVNELIYKRGYGKINKKRIA 128
Cdd:cd01657     1 LYAVVRIRGIVGVPPKIRKTLQLLRLRRINNAVFVKLTKATIGMLKKVEPYVTWGEPNLETLRELIYKRGRLKGNGQRIP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393170012 129 LTDNALIARSLgKYGIICMEDLIHEIYTVGKRFKEANNFLWPFKLSSPRGGMKKKTTHFVEGGDAGNREDQINRLIRRMN 208
Cdd:cd01657    81 LTDNYLVEKTL-KKGIICIEDLAHEIYTGGPNFKEVNNFLPPFRLHPPRGGFKGKKRHFSEGGELGYRGEDINELIRRMI 159
rpl30p PRK06049
50S ribosomal protein L30P; Reviewed
 52-207 1.42e-25

50S ribosomal protein L30P; Reviewed


Pssm-ID: 235683  Cd Length: 154  Bit Score: 96.80  E-value: 1.42e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393170012  52 VIRIRGINGVSPKVRKVLQLLRLRQIFNGTFVKLNKASINMLRIVEPYIAWGYPNLKSVNELIYKRGYGKINKKriaLTD 131
Cdd:PRK06049    5 VIRIRGRVNVPRDIADTLKMLRLHRVNHCVLVPETPSYKGMLQKVKDYVTWGEIDADTLAELLRKRGRLEGNKK---LTD 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1393170012 132 nALIARSLGKYGIicmEDLIhEIYTVGK-RFKEANNFLWPFKLSSPRGGMKKKTTHFVEGGDAGNREDQINRLIRRM 207
Cdd:PRK06049   82 -EYVKENTGYDSI---EELA-EALVEGEiKLKDLPGLKPVFRLHPPRGGFGGIKRPFKEGGELGYRGEKINELLRRM 153
Ribosomal_L30 pfam00327
Ribosomal protein L30p/L7e; This family includes prokaryotic L30 and eukaryotic L7.
 50-100 2.22e-17

Ribosomal protein L30p/L7e; This family includes prokaryotic L30 and eukaryotic L7.


Pssm-ID: 459762 [Multi-domain]  Cd Length: 51  Bit Score: 72.34  E-value: 2.22e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1393170012  50 AFVIRIRGINGVSPKVRKVLQLLRLRQIfNGTFVKLNKASIN-MLRIVEPYI 100
Cdd:pfam00327   1 LKVTRIRSIIGRPPKQRKTLKALGLRKI-NGVVVKEDTPSIRgMLRKVKHLV 51
RpmD COG1841
Ribosomal protein L30/L7E [Translation, ribosomal structure and biogenesis]; Ribosomal protein ...
 52-103 4.11e-06

Ribosomal protein L30/L7E [Translation, ribosomal structure and biogenesis]; Ribosomal protein L30/L7E is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 441446  Cd Length: 58  Bit Score: 42.72  E-value: 4.11e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1393170012  52 VIRIRGINGVSPKVRKVLQLLRLRQIFNGTFVKLNKASINMLRIVEPYIAWG 103
Cdd:COG1841     6 VTLVRSTIGRPPDQRATLKALGLRKINHTVELPDTPAIRGMINKVKHLVTVE 57
 
Name Accession Description Interval E-value
uL30_euk TIGR01310
60S ribosomal protein uL30, eukaryotic form; This model describes the eukaryotic 60S ...
 3-208 1.86e-107

60S ribosomal protein uL30, eukaryotic form; This model describes the eukaryotic 60S (cytosolic) ribosomal protein uL30 (previously L7) and paralogs that may or may not also be uL30. Human, Drosophila, and Arabidopsis all have both a typical L7 and an L7-related paralog. This family is designated subfamily rather than equivalog to reflect these uncharacterized paralogs. Members of this family average ~ 250 residues in length, somewhat longer than the archaeal L30P/L7E homolog (~ 155 residues) and much longer than the related bacterial/organellar form (~ 60 residues).


Pssm-ID: 273548 [Multi-domain]  Cd Length: 235  Bit Score: 308.14  E-value: 1.86e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393170012   3 RKARRKLIYEKAKHYHKEYRQMYRTEIRMARMARKAGNFYVPAEPKLAFVIRIRGINGVSPKVRKVLQLLRLRQIFNGTF 82
Cdd:TIGR01310  28 NKKKRKDYFKRAESFVKEYRKAERKIIRLKRLAKKPGKFYVPAEHKLVFVIRIKGINGIPPKPRKVLRLLRLKQVHNGVF 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393170012  83 VKLNKASINMLRIVEPYIAWGYPNLKSVNELIYKRGYGKINKKRIALTDNALIARSLGKYGIICMEDLIHEIYTVGKRFK 162
Cdd:TIGR01310 108 VKVNKATLEMLRIVEPYVAYGYPNLKSVRELIYKRGFAKINGQRVPLTDNAIIEQHLGKYGIICIEDLIHEIYTVGPHFK 187

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1393170012 163 EANNFLWPFKLSSPRGG--MKKKTTHFVEGGDAGNREDQINRLIRRMN 208
Cdd:TIGR01310 188 EVNNFLWPFKLSSPVKGfgKRKKVKHFIEGGDFGNREDHINELIKKMN 235
Ribosomal_L7_archeal_euk cd01657
Ribosomal protein L7, which is found in archaea and eukaryotes but not in prokaryotes, binds ...
 49-208 1.73e-91

Ribosomal protein L7, which is found in archaea and eukaryotes but not in prokaryotes, binds domain II of the 23S rRNA as well as the 5S rRNA and is one of five ribosomal proteins that mediate the interactions 5S rRNA makes with the ribosome. The eukaryotic L7 members have an N-terminal extension not found in the archeal L7 orthologs. L7 is closely related to the ribosomal L30 protein found in eukaryotes and prokaryotes.


Pssm-ID: 100099  Cd Length: 159  Bit Score: 264.77  E-value: 1.73e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393170012  49 LAFVIRIRGINGVSPKVRKVLQLLRLRQIFNGTFVKLNKASINMLRIVEPYIAWGYPNLKSVNELIYKRGYGKINKKRIA 128
Cdd:cd01657     1 LYAVVRIRGIVGVPPKIRKTLQLLRLRRINNAVFVKLTKATIGMLKKVEPYVTWGEPNLETLRELIYKRGRLKGNGQRIP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393170012 129 LTDNALIARSLgKYGIICMEDLIHEIYTVGKRFKEANNFLWPFKLSSPRGGMKKKTTHFVEGGDAGNREDQINRLIRRMN 208
Cdd:cd01657    81 LTDNYLVEKTL-KKGIICIEDLAHEIYTGGPNFKEVNNFLPPFRLHPPRGGFKGKKRHFSEGGELGYRGEDINELIRRMI 159
rpl30p PRK06049
50S ribosomal protein L30P; Reviewed
 52-207 1.42e-25

50S ribosomal protein L30P; Reviewed


Pssm-ID: 235683  Cd Length: 154  Bit Score: 96.80  E-value: 1.42e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393170012  52 VIRIRGINGVSPKVRKVLQLLRLRQIFNGTFVKLNKASINMLRIVEPYIAWGYPNLKSVNELIYKRGYGKINKKriaLTD 131
Cdd:PRK06049    5 VIRIRGRVNVPRDIADTLKMLRLHRVNHCVLVPETPSYKGMLQKVKDYVTWGEIDADTLAELLRKRGRLEGNKK---LTD 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1393170012 132 nALIARSLGKYGIicmEDLIhEIYTVGK-RFKEANNFLWPFKLSSPRGGMKKKTTHFVEGGDAGNREDQINRLIRRM 207
Cdd:PRK06049   82 -EYVKENTGYDSI---EELA-EALVEGEiKLKDLPGLKPVFRLHPPRGGFGGIKRPFKEGGELGYRGEKINELLRRM 153
Ribosomal_L30_like cd00355
Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one ...
 51-103 6.20e-18

Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that mediate the interactions 5S rRNA makes with the ribosome. The eukaryotic L30 members have N- and/or C-terminal extensions not found in their prokaryotic orthologs. L30 is closely related to the ribosomal L7 protein found in eukaryotes and archaea.


Pssm-ID: 100098 [Multi-domain]  Cd Length: 53  Bit Score: 73.98  E-value: 6.20e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1393170012  51 FVIRIRGINGVSPKVRKVLQLLRLRQIFNGTFVKLNKASINMLRIVEPYIAWG 103
Cdd:cd00355     1 KVTRVRSLIGRPPKQRKTLKALGLRKINQTVFVKDTPSIRGMLRKVKHLVTVG 53
Ribosomal_L30 pfam00327
Ribosomal protein L30p/L7e; This family includes prokaryotic L30 and eukaryotic L7.
 50-100 2.22e-17

Ribosomal protein L30p/L7e; This family includes prokaryotic L30 and eukaryotic L7.


Pssm-ID: 459762 [Multi-domain]  Cd Length: 51  Bit Score: 72.34  E-value: 2.22e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1393170012  50 AFVIRIRGINGVSPKVRKVLQLLRLRQIfNGTFVKLNKASIN-MLRIVEPYI 100
Cdd:pfam00327   1 LKVTRIRSIIGRPPKQRKTLKALGLRKI-NGVVVKEDTPSIRgMLRKVKHLV 51
Ribosomal_L30_N pfam08079
Ribosomal L30 N-terminal domain; This presumed domain is found at the N-terminus of Ribosomal ...
 2-45 3.76e-16

Ribosomal L30 N-terminal domain; This presumed domain is found at the N-terminus of Ribosomal L30 proteins and has been termed RL30NT or NUC018.


Pssm-ID: 462360  Cd Length: 72  Bit Score: 69.92  E-value: 3.76e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1393170012   2 LRKARRKLIYEKAKHYHKEYRQMYRTEIRMARMARKAGNFYVPA 45
Cdd:pfam08079  29 ANKKKRKLIFKRAEKYVKEYRRKERDEIRLKREAKKAGNFYVPA 72
RpmD COG1841
Ribosomal protein L30/L7E [Translation, ribosomal structure and biogenesis]; Ribosomal protein ...
 52-103 4.11e-06

Ribosomal protein L30/L7E [Translation, ribosomal structure and biogenesis]; Ribosomal protein L30/L7E is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 441446  Cd Length: 58  Bit Score: 42.72  E-value: 4.11e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1393170012  52 VIRIRGINGVSPKVRKVLQLLRLRQIFNGTFVKLNKASINMLRIVEPYIAWG 103
Cdd:COG1841     6 VTLVRSTIGRPPDQRATLKALGLRKINHTVELPDTPAIRGMINKVKHLVTVE 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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