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2-oxoglutarate dehydrogenase complex component E1 isoform 4 precursor [Homo sapiens]
Protein Classification
2-oxoglutarate dehydrogenase family protein ( domain architecture ID 11426267 )
2-oxoglutarate dehydrogenase family protein, such as 2-oxoglutarate dehydrogenase subunit E1 that catalyzes the decarboxylation of 2-oxoglutarate and the formation of TPP-hydroxysuccinate
List of domain hits
Name
Accession
Description
Interval
E-value
SucA
COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes ...
49-1027
0e+00
2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440333 [Multi-domain]
Cd Length: 935
Bit Score: 1320.08
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 49 FLSG TSSN Y V EE M Y CAW LE N P K SV HK SW DI FF RNTNAGAPPGTAYQ SP LPLSRGS LA AVAHAQSLVE A Q pn VDKLVEDHL 128
Cdd:COG0567 11 FLSG ANAA Y I EE L Y EQY LE D P D SV DP SW RA FF DGLPDVPGARDFAH SP IREEFRK LA KNGAGAAASA A A -- DPEAARKQV 88
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 129 A V QS LI R AY Q VRGH HI AKLDPLG I scvnfdd APVTVSSNV D L A vfkerlrmltvgg FYGL D E S DLD K VF H lp T TTFI G GQ 208
Cdd:COG0567 89 R V LQ LI N AY R VRGH LF AKLDPLG L ------- RERPYVPEL D P A ------------- FYGL T E A DLD T VF N -- T GSLL G LE 146
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 209 E sa LP LREII RR L EMA YC QH IGVE F M F I N D L E QCQ WI RQKF E TP - GIMQ F TN EEK RTL L AR L VRSTR FE E FL QR K WSSE K 287
Cdd:COG0567 147 T -- AT LREII AA L KET YC GS IGVE Y M H I S D P E EKR WI QERL E ST r NRPS F SA EEK KRI L EK L TAAEG FE K FL HT K YVGQ K 224
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 288 RF G LEG C E V LIPAL KTI I DKSS E N GV DYVIM GM P HRGRLNVL A N VIR K ELEQ IF CQ F DS K LEAADE GSGDVKYHLG m YHR 367
Cdd:COG0567 225 RF S LEG G E S LIPAL DEL I ERAG E L GV KEIVI GM A HRGRLNVL V N ILG K PPRD IF SE F EG K SAEDVL GSGDVKYHLG - FSS 303
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 368 ri NRV T D - RNIT LSL VA NPSHLE AAD PVV M G KTK A E Q FYC GDT EGK KV MS IL L HGDAAFAGQG I VYET FHL S D L PS Y T T H 446
Cdd:COG0567 304 -- DVE T P g GKVH LSL AF NPSHLE IVN PVV E G SVR A R Q DRR GDT DRD KV LP IL I HGDAAFAGQG V VYET LNM S Q L RG Y R T G 381
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 447 GT V H V V V NNQIGFTT D PR M ARSS P Y P TDVA RV V N APIFHVN S DDPEAV MY V CKV A AEW R ST F H KDVV V DLVCYRR N GHNE 526
Cdd:COG0567 382 GT I H I V I NNQIGFTT S PR D ARSS T Y C TDVA KM V Q APIFHVN G DDPEAV VF V ARL A LDY R QK F K KDVV I DLVCYRR H GHNE 461
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 527 M DEP M FTQPLMYK Q I R K QKPVLQK YA EL LV SQ GV VNQP E YE E EISK Y DKICE E A F ARS K d E KILHIKH WL DSP W PGFFT L 606
Cdd:COG0567 462 G DEP A FTQPLMYK K I K K HPTTREI YA DK LV AE GV ITAE E AD E MVDE Y RAALD E G F EVV K - E YKPNKAD WL EGD W SPYRR L 540
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 607 d G QPRSMSCP s TG LTEDI L THI G NVASSV P v E N F TI H GGLSR IL KT R GE M V - KNRTV DW AL AE YM A FG SLL K EG IHI RLS 685
Cdd:COG0567 541 - G EDWDDPVD - TG VPLEK L KEL G EKLTTL P - E G F KL H PKVEK IL ED R RK M A e GEKPL DW GM AE AL A YA SLL D EG YPV RLS 617
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 686 GQD VE RGTFSHRH H VLHDQ N v DKR T CI P M NHL WPN QA PYT V C NS S LSE YG VLGFE L G F A M A S PN A LV L WEAQFGDF H N T A 765
Cdd:COG0567 618 GQD SG RGTFSHRH A VLHDQ K - TGE T YV P L NHL SEG QA RFE V Y NS L LSE EA VLGFE Y G Y A L A E PN T LV I WEAQFGDF A N G A 696
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 766 Q CI IDQFI CP G QA KW V R QN G I V L LLPHG M EG M GPEHSSAR P ERFLQ M C ND D pdvlpdlkeanfdinqlydc N WV V V N CS T 845
Cdd:COG0567 697 Q VV IDQFI SS G ES KW G R LS G L V M LLPHG Y EG Q GPEHSSAR L ERFLQ L C AE D -------------------- N MQ V C N PT T 756
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 846 P GNF FH V LRRQ ILL PFRKPLI IF TPKSLLRH PE A R SS FD E MLP G t H FQ R VI PEDGPA aq N P EN VKR LLF C T GKVYYDL T - 924
Cdd:COG0567 757 P AQY FH L LRRQ MKR PFRKPLI VM TPKSLLRH KL A V SS LE E LAE G - S FQ E VI DDTDEL -- D P KK VKR VVL C S GKVYYDL L e 833
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 925 -- RER KAR D mvgq VAI T RIEQL S PFP FDL L LK E VQ KYPNA - E LA WCQEE H KN Q G YYDYVKP RL RTTISRAKPVW YAGR DP 1001
Cdd:COG0567 834 er RER GRD D ---- VAI V RIEQL Y PFP EEE L AA E LA KYPNA k E VV WCQEE P KN M G AWYFIQH RL EEVLPKGQRLR YAGR PA 909
970 980
....*....|....*....|....*.
gi 1391723613 1002 A A A PATG NKKT H LT E LQR L LDT A FDL 1027
Cdd:COG0567 910 S A S PATG YMSV H KA E QKA L VEE A LGI 935
Name
Accession
Description
Interval
E-value
SucA
COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes ...
49-1027
0e+00
2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440333 [Multi-domain]
Cd Length: 935
Bit Score: 1320.08
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 49 FLSG TSSN Y V EE M Y CAW LE N P K SV HK SW DI FF RNTNAGAPPGTAYQ SP LPLSRGS LA AVAHAQSLVE A Q pn VDKLVEDHL 128
Cdd:COG0567 11 FLSG ANAA Y I EE L Y EQY LE D P D SV DP SW RA FF DGLPDVPGARDFAH SP IREEFRK LA KNGAGAAASA A A -- DPEAARKQV 88
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 129 A V QS LI R AY Q VRGH HI AKLDPLG I scvnfdd APVTVSSNV D L A vfkerlrmltvgg FYGL D E S DLD K VF H lp T TTFI G GQ 208
Cdd:COG0567 89 R V LQ LI N AY R VRGH LF AKLDPLG L ------- RERPYVPEL D P A ------------- FYGL T E A DLD T VF N -- T GSLL G LE 146
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 209 E sa LP LREII RR L EMA YC QH IGVE F M F I N D L E QCQ WI RQKF E TP - GIMQ F TN EEK RTL L AR L VRSTR FE E FL QR K WSSE K 287
Cdd:COG0567 147 T -- AT LREII AA L KET YC GS IGVE Y M H I S D P E EKR WI QERL E ST r NRPS F SA EEK KRI L EK L TAAEG FE K FL HT K YVGQ K 224
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 288 RF G LEG C E V LIPAL KTI I DKSS E N GV DYVIM GM P HRGRLNVL A N VIR K ELEQ IF CQ F DS K LEAADE GSGDVKYHLG m YHR 367
Cdd:COG0567 225 RF S LEG G E S LIPAL DEL I ERAG E L GV KEIVI GM A HRGRLNVL V N ILG K PPRD IF SE F EG K SAEDVL GSGDVKYHLG - FSS 303
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 368 ri NRV T D - RNIT LSL VA NPSHLE AAD PVV M G KTK A E Q FYC GDT EGK KV MS IL L HGDAAFAGQG I VYET FHL S D L PS Y T T H 446
Cdd:COG0567 304 -- DVE T P g GKVH LSL AF NPSHLE IVN PVV E G SVR A R Q DRR GDT DRD KV LP IL I HGDAAFAGQG V VYET LNM S Q L RG Y R T G 381
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 447 GT V H V V V NNQIGFTT D PR M ARSS P Y P TDVA RV V N APIFHVN S DDPEAV MY V CKV A AEW R ST F H KDVV V DLVCYRR N GHNE 526
Cdd:COG0567 382 GT I H I V I NNQIGFTT S PR D ARSS T Y C TDVA KM V Q APIFHVN G DDPEAV VF V ARL A LDY R QK F K KDVV I DLVCYRR H GHNE 461
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 527 M DEP M FTQPLMYK Q I R K QKPVLQK YA EL LV SQ GV VNQP E YE E EISK Y DKICE E A F ARS K d E KILHIKH WL DSP W PGFFT L 606
Cdd:COG0567 462 G DEP A FTQPLMYK K I K K HPTTREI YA DK LV AE GV ITAE E AD E MVDE Y RAALD E G F EVV K - E YKPNKAD WL EGD W SPYRR L 540
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 607 d G QPRSMSCP s TG LTEDI L THI G NVASSV P v E N F TI H GGLSR IL KT R GE M V - KNRTV DW AL AE YM A FG SLL K EG IHI RLS 685
Cdd:COG0567 541 - G EDWDDPVD - TG VPLEK L KEL G EKLTTL P - E G F KL H PKVEK IL ED R RK M A e GEKPL DW GM AE AL A YA SLL D EG YPV RLS 617
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 686 GQD VE RGTFSHRH H VLHDQ N v DKR T CI P M NHL WPN QA PYT V C NS S LSE YG VLGFE L G F A M A S PN A LV L WEAQFGDF H N T A 765
Cdd:COG0567 618 GQD SG RGTFSHRH A VLHDQ K - TGE T YV P L NHL SEG QA RFE V Y NS L LSE EA VLGFE Y G Y A L A E PN T LV I WEAQFGDF A N G A 696
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 766 Q CI IDQFI CP G QA KW V R QN G I V L LLPHG M EG M GPEHSSAR P ERFLQ M C ND D pdvlpdlkeanfdinqlydc N WV V V N CS T 845
Cdd:COG0567 697 Q VV IDQFI SS G ES KW G R LS G L V M LLPHG Y EG Q GPEHSSAR L ERFLQ L C AE D -------------------- N MQ V C N PT T 756
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 846 P GNF FH V LRRQ ILL PFRKPLI IF TPKSLLRH PE A R SS FD E MLP G t H FQ R VI PEDGPA aq N P EN VKR LLF C T GKVYYDL T - 924
Cdd:COG0567 757 P AQY FH L LRRQ MKR PFRKPLI VM TPKSLLRH KL A V SS LE E LAE G - S FQ E VI DDTDEL -- D P KK VKR VVL C S GKVYYDL L e 833
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 925 -- RER KAR D mvgq VAI T RIEQL S PFP FDL L LK E VQ KYPNA - E LA WCQEE H KN Q G YYDYVKP RL RTTISRAKPVW YAGR DP 1001
Cdd:COG0567 834 er RER GRD D ---- VAI V RIEQL Y PFP EEE L AA E LA KYPNA k E VV WCQEE P KN M G AWYFIQH RL EEVLPKGQRLR YAGR PA 909
970 980
....*....|....*....|....*.
gi 1391723613 1002 A A A PATG NKKT H LT E LQR L LDT A FDL 1027
Cdd:COG0567 910 S A S PATG YMSV H KA E QKA L VEE A LGI 935
sucA
PRK09404 2-oxoglutarate dehydrogenase E1 component; Reviewed
49-1026
0e+00
2-oxoglutarate dehydrogenase E1 component; Reviewed
Pssm-ID: 236499 [Multi-domain]
Cd Length: 924
Bit Score: 1271.20
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 49 FL S G TSSN Y V EE M Y CAW L EN P K SV HKS W DI FF RNTNAG AP PGTA yqsplplsrgs L A AVAHAQS L VEAQPNVDKLVEDHL 128
Cdd:PRK09404 13 FL F G ANAA Y I EE L Y EQY L KD P D SV DEE W RA FF DGLPGV AP DVAH ----------- S A VRESFRR L AKPARVSSAVSDPQV 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 129 A V QS LI R AY QV RGH HI A K LDPLG I scvnfdd APVTVSSNV D L A vfkerlrmltvgg FYGL D E S DLD KV F H lp T TTFIG G Q 208
Cdd:PRK09404 82 K V LQ LI N AY RF RGH LA A N LDPLG L ------- WKRPDVPEL D P A ------------- FYGL T E A DLD RT F N -- T GSLAL G K 139
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 209 E S A l P LREII RR L EMA YC QH IGVE F M F I N D L E QCQ W IR Q KF E TPGI m Q F TN EEK RTL L A RL VRSTR FE E FL QR K WSSE KR 288
Cdd:PRK09404 140 E T A - T LREII EA L KKT YC GS IGVE Y M H I S D P E ERR W LQ Q RI E SGRP - S F SA EEK KAI L E RL TAAEG FE R FL HT K FVGQ KR 217
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 289 F G LEG C E V LIP A L KT II DKSSEN GV DYVIM GM P HRGRLNVL A NV IR K ELEQI F CQ F DS K LEAAD - E GSGDVKYHLG m YHR 367
Cdd:PRK09404 218 F S LEG G E S LIP M L DE II RRAGKL GV KEIVI GM A HRGRLNVL V NV LG K PPRDL F AE F EG K HGPDE v L GSGDVKYHLG - FSS 296
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 368 ri N R V TD - RNIT LSL VA NPSHLE AAD PVV M G KTK A E Q FYC GD - TEG KKV MS IL L HGDAAFAGQG I V Y ET FH LS D L PS Y T T 445
Cdd:PRK09404 297 -- D R E TD g GEVH LSL AF NPSHLE IVN PVV E G SVR A R Q DRR GD g QDR KKV LP IL I HGDAAFAGQG V V A ET LN LS Q L RG Y R T 374
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 446 H GT V H V V V NNQIGFTT D P RMA RS S PY P TDVA RV V N APIFHVN S DDPEAV MYVCKV A A E W R ST F H KDVV V DLVCYRR N GHN 525
Cdd:PRK09404 375 G GT I H I V I NNQIGFTT S P PDD RS T PY C TDVA KM V Q APIFHVN G DDPEAV VFATRL A L E Y R QK F K KDVV I DLVCYRR H GHN 454
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 526 E M DEP M FTQPLMYK Q I R K QKPVLQK YA EL LV SQ GV VNQP E YE E EISK Y DKICEEA F ARS K DEK ilh IKH WL DSP W PGFFT 605
Cdd:PRK09404 455 E G DEP S FTQPLMYK K I K K HPTTREL YA DK LV AE GV ITEE E AD E MVNE Y RDALDAG F EVV K EWR --- PAD WL AGD W SPYLG 531
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 606 LDGQPR smsc PS TG LTEDI L THIGNVASS VP v E N F TI H GGLSR IL KT R G EM VK - NRTV DW AL AE YM AF G SLL K EG IHI RL 684
Cdd:PRK09404 532 HEWDDP ---- VD TG VPLER L KELAEKLTT VP - E G F KV H PKVKK IL ED R R EM AE g EKPI DW GM AE AL AF A SLL D EG YPV RL 606
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 685 SGQD VE RGTFSHRH H VLHDQ N v DKR T C IP M NHL WPN QA PYT V CN S S LSE YG VLGFE L G FAM A S PN A LV L WEAQFGDF H N T 764
Cdd:PRK09404 607 SGQD SG RGTFSHRH A VLHDQ K - TGE T Y IP L NHL SEG QA SFE V YD S P LSE EA VLGFE Y G YST A E PN T LV I WEAQFGDF A N G 685
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 765 AQ CI IDQFI CP G QA KW V R QN G I V L LLPHG M EG M GPEHSSAR P ERFLQ M C ND D pdvlpdlkeanfdinqlydc N WV V V N CS 844
Cdd:PRK09404 686 AQ VV IDQFI SS G EQ KW G R LS G L V M LLPHG Y EG Q GPEHSSAR L ERFLQ L C AE D -------------------- N MQ V C N PT 745
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 845 TP GNF FH V LRRQ I L L PFRKPL IIF TPKSLLRHP E A R SS FD E MLP G T h FQ R VI PE dg PAAQN P EN VKR LLF C T GKVYYDL T 924
Cdd:PRK09404 746 TP AQY FH L LRRQ A L R PFRKPL VVM TPKSLLRHP L A V SS LE E LAE G S - FQ P VI GD -- IDELD P KK VKR VVL C S GKVYYDL L 822
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 925 RE R KA R D m VGQ VAI T RIEQL S PFP FDL L LK E VQ KYPNA - E LA WCQEE H KNQG YYDYVKPR L RTTISRAKPVW YAGR DPA A 1003
Cdd:PRK09404 823 EA R RK R G - IDD VAI V RIEQL Y PFP HEE L AA E LA KYPNA k E VV WCQEE P KNQG AWYFIQHH L EEVLPEGQKLR YAGR PAS A 901
970 980
....*....|....*....|...
gi 1391723613 1004 A PA T G NKKT H LTELQR L LDT A FD 1026
Cdd:PRK09404 902 S PA V G YMSL H KKQQEA L VED A LG 924
2oxo_dh_E1
TIGR00239 2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists ...
49-1025
0e+00
2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists of this thiamine pyrophosphate-binding subunit (E1), dihydrolipoamide succinyltransferase (E2), and lipoamide dehydrogenase (E3). The E1 ortholog from Corynebacterium glutamicum is unusual in having an N-terminal extension that resembles the dihydrolipoamide succinyltransferase (E2) component of 2-oxoglutarate dehydrogenase. [Energy metabolism, TCA cycle]
Pssm-ID: 161785 [Multi-domain]
Cd Length: 929
Bit Score: 987.06
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 49 F LSG TSSN Y V EE M Y CAW L EN P K SV HK SW DIF F RNTNAGA P PGTAYQ SP LPLSRGS LA AV A HAQ S LVEAQ P nv D KL V EDHL 128
Cdd:TIGR00239 1 Y LSG ANQS Y I EE L Y EDY L TD P D SV DA SW RST F DQLPGPG P APDQFH SP TRSYFRR LA KD A SRG S VTISD P -- D TN V SQVK 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 129 AV Q s LIRAY QV RGH HI A K LDPLG iscv NFD dap VTVSSNV DL A vfkerlrmltvgg FYGL D E S DL DKV F HLPTTTFIGGQ 208
Cdd:TIGR00239 79 VL Q - LIRAY RF RGH LH A N LDPLG ---- LKQ --- QDKVPEL DL S ------------- FYGL T E A DL QET F NIGSFVSGKDA 137
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 209 ESA L PLR E IIRR L EMA YC QH IG V E F M F I NDL E QCQ W IR Q KF E TPGIM QF TN EEK RTL L A RL VRSTR FE E FL QR K WSSE KR 288
Cdd:TIGR00239 138 TMK L SNL E LLQA L KQT YC GS IG A E Y M H I TST E EKR W LQ Q RI E SGERA QF NS EEK KRF L S RL TAAEG FE R FL GA K FPGA KR 217
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 289 F G LEG CEV L I P A LK T II DK S SEN G VDY V IM GM P HRGRLNVL A NV IR K EL E Q IF CQ F DS K LEAAD - E G S GDVKYH L G MYHR 367
Cdd:TIGR00239 218 F S LEG LDA L V P M LK E II RH S VNS G TRD V VL GM A HRGRLNVL V NV LG K PP E D IF SE F AG K HKSHL p D G T GDVKYH M G RFSS 297
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 368 RIN r VTDRNIT L S L VA NPSHLE AAD PVV M G K T K A EQFYCG D - T E GK KV MS IL L HGDAAFAGQG I V Y ET FHL S D L PS Y TTH 446
Cdd:TIGR00239 298 DFT - TDGKLVH L A L AF NPSHLE IVS PVV I G S T R A RLDRLN D s P E ST KV LA IL I HGDAAFAGQG V V Q ET LNM S K L RG Y SVG 376
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 447 GT V H VVV NNQIGFTT D P RM ARS S PY PT D V A RVVN APIFHVN S DDPEAV MYVCKV A A E W R S TF HK DV VV DLV C YRR N GHNE 526
Cdd:TIGR00239 377 GT I H III NNQIGFTT N P LD ARS T PY CS D L A KMIQ APIFHVN A DDPEAV AFATRL A V E Y R N TF KR DV FI DLV G YRR H GHNE 456
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 527 M DEP MF TQPLMY KQ I R K QKPVLQK YA EL LVS Q GV VN qpey EE EISKYDKICEE A FARSKD e KILHIKHWLDSPWPGFFT L 606
Cdd:TIGR00239 457 A DEP SA TQPLMY QK I K K HPTPRKV YA DK LVS E GV AT ---- EE DVTEMVNLYRD A LEAADC - VVPSWREMNTASFTWSPE L 531
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 607 D g QPRSMSC P ST g LTEDI L THIGNVA S S VP v E NFTI H GGLSR I LKT R GEMVK -- NRTV DW AL AE YM AF GS L LKE GI HI RL 684
Cdd:TIGR00239 532 N - HEWDEEY P NK - VEMKR L QELAKRI S E VP - E GVEM H SRVAK I YFD R TKAMA ag EKLF DW GG AE NL AF AT L VDD GI PV RL 608
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 685 SG Q D V ERGTF SH RH H VLHDQ N v DKR T CI P MN HL WPN Q APYT V C NS S LSE YG VLGFE L G F A MA SP NA LV L WEAQFGDF H N T 764
Cdd:TIGR00239 609 SG E D S ERGTF FQ RH A VLHDQ S - NGS T YT P LQ HL HNG Q GAFR V W NS V LSE ES VLGFE Y G Y A TT SP RT LV I WEAQFGDF A N G 687
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 765 AQ CI IDQFI CP G QA KW VRQN G I V L LLPHG M EG M GPEHSS A R P ERFLQ MCNDD pdvlpdlkeanfdinqlydc N WV V VNCS 844
Cdd:TIGR00239 688 AQ VV IDQFI SS G EQ KW GQMS G L V M LLPHG Y EG Q GPEHSS G R L ERFLQ LAAEQ -------------------- N MQ V CVPT 747
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 845 TP GNF FH V LRRQ I L LPF R K PL IIFT PKSLLRHP E A R SS FD E MLP GT h FQ R VI P -- E DGPAAQN PE N VKRL LF C T GKVYYD 922
Cdd:TIGR00239 748 TP AQV FH I LRRQ A L RGM R R PL VVMS PKSLLRHP L A V SS LE E LAE GT - FQ P VI G ei E ESGLSLD PE G VKRL VL C S GKVYYD 826
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 923 L t R E RKARDMVGQ VAI T RIEQL S PFP FDLLLKEV Q K YPN - A E LA WCQEE HK N Q G YYD Y VK P R LR TT I SRAKP V W YAGR DP 1001
Cdd:TIGR00239 827 L - H E QRRKNGQKD VAI V RIEQL Y PFP HKAVKEVL Q Q YPN l K E IV WCQEE PL N M G AWY Y SQ P H LR EV I PEGVS V R YAGR PA 905
970 980
....*....|....*....|....
gi 1391723613 1002 A A A PA T G NKKT H LTEL Q R LL DT A F 1025
Cdd:TIGR00239 906 S A S PA V G YMSL H QKQQ Q D LL ND A L 929
TPP_E1_OGDC_like
cd02016 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed ...
275-538
2.30e-179
Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of the tricarboxylic acid cycle.
Pssm-ID: 238974 [Multi-domain]
Cd Length: 265
Bit Score: 522.09
E-value: 2.30e-179
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 275 FE E FL QR K WSSE KRFGLEG C E V LIPAL KTI ID KSS E N GV DY V IM GM P HRGRLNVLANV IR K E LEQIF CQ F DS K L E AAD -- 352
Cdd:cd02016 1 FE Q FL AT K FPGQ KRFGLEG A E S LIPAL DEL ID RAA E L GV EE V VI GM A HRGRLNVLANV LG K P LEQIF SE F EG K S E FPE dd 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 353 EGSGDVKYHLG MYHR R INRV t DRNIT LSL VA NPSHLEA AD PVVMGKT K A E Q F Y C GD T E GK KV MS IL L HGDAAFAGQG I VY 432
Cdd:cd02016 81 EGSGDVKYHLG YSSD R KTPS - GKKVH LSL AP NPSHLEA VN PVVMGKT R A K Q D Y R GD G E RD KV LP IL I HGDAAFAGQG V VY 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 433 ET FH LS D LP S YTT H GT V H V VVNNQIGFTTDPR MA RSSPY P TDVA RVVN APIFHVN S DDPEAV MYVCKV A A E W R ST F H KDV 512
Cdd:cd02016 160 ET LN LS N LP G YTT G GT I H I VVNNQIGFTTDPR DS RSSPY C TDVA KMIG APIFHVN G DDPEAV VRATRL A L E Y R QK F K KDV 239
250 260
....*....|....*....|....*.
gi 1391723613 513 V V DLVCYRR N GHNE M DEP M FTQPLMY 538
Cdd:cd02016 240 V I DLVCYRR H GHNE L DEP S FTQPLMY 265
E1_dh
pfam00676 Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family ...
267-593
8.69e-112
Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family includes pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and 2-oxoisovalerate dehydrogenase.
Pssm-ID: 395548 [Multi-domain]
Cd Length: 300
Bit Score: 348.16
E-value: 8.69e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 267 A R LVRST R F E EFLQRKWSSEKRF G LEGCEVLIP A LKTI I DKSS E N G v DY V I M G mp H R GRL N V LA NVIR ke LE Q IF CQFDS 346
Cdd:pfam00676 1 R R MMTLR R M E DARDALYKRQGIR G FYHLYAGQE A AQVG I AAAL E P G - DY I I P G -- Y R DHG N L LA RGLS -- LE E IF AELYG 75
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 347 KLE aad E G S G DVKY hl G M Y HRRI NR VTDR N IT L SLVAN pshl EA A DPVVMG K T kaeqfycgdt E GKK VMS I L L H GD A A f A 426
Cdd:pfam00676 76 RVA --- K G K G GSMH -- G Y Y GAKG NR FYGG N GI L GAQVP ---- LG A GIALAA K Y ---------- R GKK EVA I T L Y GD G A - A 135
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 427 G QG IVY E TFHLSD L PSYTT hgt VH V VV NNQ I G FT T DPRM A RS S PYPT D V AR VVNA P IF HV NSD DP E AV MYVC K V AAE WRS 506
Cdd:pfam00676 136 N QG DFF E GLNFAA L WKLPV --- IF V CE NNQ Y G IS T PAER A SA S TTYA D R AR GYGI P GL HV DGM DP L AV YQAS K F AAE RAR 212
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 507 T FHKDVVVD LV C YR RN GH NEM D E P MFTQ - PLM Y KQI RK Q K PVL Q KYA E L LVS Q GV VNQP E YEEEISKYD K IC EEAF ARSK 585
Cdd:pfam00676 213 T GKGPFLIE LV T YR YG GH SMS D D P STYR t RDE Y EEV RK K K DPI Q RFK E H LVS K GV WSEE E LKAIEKEVR K EV EEAF KKAE 292
....*...
gi 1391723613 586 DEKIL H IK 593
Cdd:pfam00676 293 SAPEP H PE 300
Transket_pyr
smart00861 Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer ...
728-875
4.24e-22
Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor, such as ribose 5-phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3- phosphate. This enzyme, together with transaldolase, provides a link between the glycolytic and pentose-phosphate pathways. TK requires thiamine pyrophosphate as a cofactor. In most sources where TK has been purified, it is a homodimer of approximately 70 Kd subunits. TK sequences from a variety of eukaryotic and prokaryotic sources show that the enzyme has been evolutionarily conserved. In the peroxisomes of methylotrophic yeast Hansenula polymorpha, there is a highly related enzyme, dihydroxy-acetone synthase (DHAS) (also known as formaldehyde transketolase), which exhibits a very unusual specificity by including formaldehyde amongst its substrates.
Pssm-ID: 214865 [Multi-domain]
Cd Length: 136
Bit Score: 92.93
E-value: 4.24e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 728 NSSLS E YGVL GF EL G F A MA spn A L VLWEAQ F GD F HNT A QCI I DQFIC pgqak WVRQNGIVLLLPH G ME G M - GP E H S S ARP 806
Cdd:smart00861 19 DTGIA E QAMV GF AA G L A LH --- G L RPVVEI F FT F FDR A KDQ I RSAGA ----- SGNVPVVFRHDGG G GV G E d GP T H H S IED 90
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 807 E - RFLQM cnddpdvlpdlkeanfdinqlyd CNWV VV NC S T P GNFFHV LR RQ I LLP f RKPL I IFTP KSL L R 875
Cdd:smart00861 91 E a LLRAI ----------------------- PGLK VV AP S D P AEAKGL LR AA I RDD - GPVV I RLER KSL Y R 136
Name
Accession
Description
Interval
E-value
SucA
COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes ...
49-1027
0e+00
2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440333 [Multi-domain]
Cd Length: 935
Bit Score: 1320.08
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 49 FLSG TSSN Y V EE M Y CAW LE N P K SV HK SW DI FF RNTNAGAPPGTAYQ SP LPLSRGS LA AVAHAQSLVE A Q pn VDKLVEDHL 128
Cdd:COG0567 11 FLSG ANAA Y I EE L Y EQY LE D P D SV DP SW RA FF DGLPDVPGARDFAH SP IREEFRK LA KNGAGAAASA A A -- DPEAARKQV 88
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 129 A V QS LI R AY Q VRGH HI AKLDPLG I scvnfdd APVTVSSNV D L A vfkerlrmltvgg FYGL D E S DLD K VF H lp T TTFI G GQ 208
Cdd:COG0567 89 R V LQ LI N AY R VRGH LF AKLDPLG L ------- RERPYVPEL D P A ------------- FYGL T E A DLD T VF N -- T GSLL G LE 146
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 209 E sa LP LREII RR L EMA YC QH IGVE F M F I N D L E QCQ WI RQKF E TP - GIMQ F TN EEK RTL L AR L VRSTR FE E FL QR K WSSE K 287
Cdd:COG0567 147 T -- AT LREII AA L KET YC GS IGVE Y M H I S D P E EKR WI QERL E ST r NRPS F SA EEK KRI L EK L TAAEG FE K FL HT K YVGQ K 224
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 288 RF G LEG C E V LIPAL KTI I DKSS E N GV DYVIM GM P HRGRLNVL A N VIR K ELEQ IF CQ F DS K LEAADE GSGDVKYHLG m YHR 367
Cdd:COG0567 225 RF S LEG G E S LIPAL DEL I ERAG E L GV KEIVI GM A HRGRLNVL V N ILG K PPRD IF SE F EG K SAEDVL GSGDVKYHLG - FSS 303
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 368 ri NRV T D - RNIT LSL VA NPSHLE AAD PVV M G KTK A E Q FYC GDT EGK KV MS IL L HGDAAFAGQG I VYET FHL S D L PS Y T T H 446
Cdd:COG0567 304 -- DVE T P g GKVH LSL AF NPSHLE IVN PVV E G SVR A R Q DRR GDT DRD KV LP IL I HGDAAFAGQG V VYET LNM S Q L RG Y R T G 381
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 447 GT V H V V V NNQIGFTT D PR M ARSS P Y P TDVA RV V N APIFHVN S DDPEAV MY V CKV A AEW R ST F H KDVV V DLVCYRR N GHNE 526
Cdd:COG0567 382 GT I H I V I NNQIGFTT S PR D ARSS T Y C TDVA KM V Q APIFHVN G DDPEAV VF V ARL A LDY R QK F K KDVV I DLVCYRR H GHNE 461
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 527 M DEP M FTQPLMYK Q I R K QKPVLQK YA EL LV SQ GV VNQP E YE E EISK Y DKICE E A F ARS K d E KILHIKH WL DSP W PGFFT L 606
Cdd:COG0567 462 G DEP A FTQPLMYK K I K K HPTTREI YA DK LV AE GV ITAE E AD E MVDE Y RAALD E G F EVV K - E YKPNKAD WL EGD W SPYRR L 540
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 607 d G QPRSMSCP s TG LTEDI L THI G NVASSV P v E N F TI H GGLSR IL KT R GE M V - KNRTV DW AL AE YM A FG SLL K EG IHI RLS 685
Cdd:COG0567 541 - G EDWDDPVD - TG VPLEK L KEL G EKLTTL P - E G F KL H PKVEK IL ED R RK M A e GEKPL DW GM AE AL A YA SLL D EG YPV RLS 617
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 686 GQD VE RGTFSHRH H VLHDQ N v DKR T CI P M NHL WPN QA PYT V C NS S LSE YG VLGFE L G F A M A S PN A LV L WEAQFGDF H N T A 765
Cdd:COG0567 618 GQD SG RGTFSHRH A VLHDQ K - TGE T YV P L NHL SEG QA RFE V Y NS L LSE EA VLGFE Y G Y A L A E PN T LV I WEAQFGDF A N G A 696
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 766 Q CI IDQFI CP G QA KW V R QN G I V L LLPHG M EG M GPEHSSAR P ERFLQ M C ND D pdvlpdlkeanfdinqlydc N WV V V N CS T 845
Cdd:COG0567 697 Q VV IDQFI SS G ES KW G R LS G L V M LLPHG Y EG Q GPEHSSAR L ERFLQ L C AE D -------------------- N MQ V C N PT T 756
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 846 P GNF FH V LRRQ ILL PFRKPLI IF TPKSLLRH PE A R SS FD E MLP G t H FQ R VI PEDGPA aq N P EN VKR LLF C T GKVYYDL T - 924
Cdd:COG0567 757 P AQY FH L LRRQ MKR PFRKPLI VM TPKSLLRH KL A V SS LE E LAE G - S FQ E VI DDTDEL -- D P KK VKR VVL C S GKVYYDL L e 833
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 925 -- RER KAR D mvgq VAI T RIEQL S PFP FDL L LK E VQ KYPNA - E LA WCQEE H KN Q G YYDYVKP RL RTTISRAKPVW YAGR DP 1001
Cdd:COG0567 834 er RER GRD D ---- VAI V RIEQL Y PFP EEE L AA E LA KYPNA k E VV WCQEE P KN M G AWYFIQH RL EEVLPKGQRLR YAGR PA 909
970 980
....*....|....*....|....*.
gi 1391723613 1002 A A A PATG NKKT H LT E LQR L LDT A FDL 1027
Cdd:COG0567 910 S A S PATG YMSV H KA E QKA L VEE A LGI 935
sucA
PRK09404 2-oxoglutarate dehydrogenase E1 component; Reviewed
49-1026
0e+00
2-oxoglutarate dehydrogenase E1 component; Reviewed
Pssm-ID: 236499 [Multi-domain]
Cd Length: 924
Bit Score: 1271.20
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 49 FL S G TSSN Y V EE M Y CAW L EN P K SV HKS W DI FF RNTNAG AP PGTA yqsplplsrgs L A AVAHAQS L VEAQPNVDKLVEDHL 128
Cdd:PRK09404 13 FL F G ANAA Y I EE L Y EQY L KD P D SV DEE W RA FF DGLPGV AP DVAH ----------- S A VRESFRR L AKPARVSSAVSDPQV 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 129 A V QS LI R AY QV RGH HI A K LDPLG I scvnfdd APVTVSSNV D L A vfkerlrmltvgg FYGL D E S DLD KV F H lp T TTFIG G Q 208
Cdd:PRK09404 82 K V LQ LI N AY RF RGH LA A N LDPLG L ------- WKRPDVPEL D P A ------------- FYGL T E A DLD RT F N -- T GSLAL G K 139
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 209 E S A l P LREII RR L EMA YC QH IGVE F M F I N D L E QCQ W IR Q KF E TPGI m Q F TN EEK RTL L A RL VRSTR FE E FL QR K WSSE KR 288
Cdd:PRK09404 140 E T A - T LREII EA L KKT YC GS IGVE Y M H I S D P E ERR W LQ Q RI E SGRP - S F SA EEK KAI L E RL TAAEG FE R FL HT K FVGQ KR 217
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 289 F G LEG C E V LIP A L KT II DKSSEN GV DYVIM GM P HRGRLNVL A NV IR K ELEQI F CQ F DS K LEAAD - E GSGDVKYHLG m YHR 367
Cdd:PRK09404 218 F S LEG G E S LIP M L DE II RRAGKL GV KEIVI GM A HRGRLNVL V NV LG K PPRDL F AE F EG K HGPDE v L GSGDVKYHLG - FSS 296
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 368 ri N R V TD - RNIT LSL VA NPSHLE AAD PVV M G KTK A E Q FYC GD - TEG KKV MS IL L HGDAAFAGQG I V Y ET FH LS D L PS Y T T 445
Cdd:PRK09404 297 -- D R E TD g GEVH LSL AF NPSHLE IVN PVV E G SVR A R Q DRR GD g QDR KKV LP IL I HGDAAFAGQG V V A ET LN LS Q L RG Y R T 374
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 446 H GT V H V V V NNQIGFTT D P RMA RS S PY P TDVA RV V N APIFHVN S DDPEAV MYVCKV A A E W R ST F H KDVV V DLVCYRR N GHN 525
Cdd:PRK09404 375 G GT I H I V I NNQIGFTT S P PDD RS T PY C TDVA KM V Q APIFHVN G DDPEAV VFATRL A L E Y R QK F K KDVV I DLVCYRR H GHN 454
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 526 E M DEP M FTQPLMYK Q I R K QKPVLQK YA EL LV SQ GV VNQP E YE E EISK Y DKICEEA F ARS K DEK ilh IKH WL DSP W PGFFT 605
Cdd:PRK09404 455 E G DEP S FTQPLMYK K I K K HPTTREL YA DK LV AE GV ITEE E AD E MVNE Y RDALDAG F EVV K EWR --- PAD WL AGD W SPYLG 531
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 606 LDGQPR smsc PS TG LTEDI L THIGNVASS VP v E N F TI H GGLSR IL KT R G EM VK - NRTV DW AL AE YM AF G SLL K EG IHI RL 684
Cdd:PRK09404 532 HEWDDP ---- VD TG VPLER L KELAEKLTT VP - E G F KV H PKVKK IL ED R R EM AE g EKPI DW GM AE AL AF A SLL D EG YPV RL 606
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 685 SGQD VE RGTFSHRH H VLHDQ N v DKR T C IP M NHL WPN QA PYT V CN S S LSE YG VLGFE L G FAM A S PN A LV L WEAQFGDF H N T 764
Cdd:PRK09404 607 SGQD SG RGTFSHRH A VLHDQ K - TGE T Y IP L NHL SEG QA SFE V YD S P LSE EA VLGFE Y G YST A E PN T LV I WEAQFGDF A N G 685
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 765 AQ CI IDQFI CP G QA KW V R QN G I V L LLPHG M EG M GPEHSSAR P ERFLQ M C ND D pdvlpdlkeanfdinqlydc N WV V V N CS 844
Cdd:PRK09404 686 AQ VV IDQFI SS G EQ KW G R LS G L V M LLPHG Y EG Q GPEHSSAR L ERFLQ L C AE D -------------------- N MQ V C N PT 745
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 845 TP GNF FH V LRRQ I L L PFRKPL IIF TPKSLLRHP E A R SS FD E MLP G T h FQ R VI PE dg PAAQN P EN VKR LLF C T GKVYYDL T 924
Cdd:PRK09404 746 TP AQY FH L LRRQ A L R PFRKPL VVM TPKSLLRHP L A V SS LE E LAE G S - FQ P VI GD -- IDELD P KK VKR VVL C S GKVYYDL L 822
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 925 RE R KA R D m VGQ VAI T RIEQL S PFP FDL L LK E VQ KYPNA - E LA WCQEE H KNQG YYDYVKPR L RTTISRAKPVW YAGR DPA A 1003
Cdd:PRK09404 823 EA R RK R G - IDD VAI V RIEQL Y PFP HEE L AA E LA KYPNA k E VV WCQEE P KNQG AWYFIQHH L EEVLPEGQKLR YAGR PAS A 901
970 980
....*....|....*....|...
gi 1391723613 1004 A PA T G NKKT H LTELQR L LDT A FD 1026
Cdd:PRK09404 902 S PA V G YMSL H KKQQEA L VED A LG 924
kgd
PRK12270 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
117-1027
0e+00
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;
Pssm-ID: 237030 [Multi-domain]
Cd Length: 1228
Bit Score: 1020.59
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 117 QPNVDKL V EDHLA V QS LI R AY Q VRGH HI A KL DPL GI scvnfddapv TVS S NV DL A V fkerlrmltvg GFY GL DES DLD KV 196
Cdd:PRK12270 376 PADHEDE V DKNAR V ME LI H AY R VRGH LM A DT DPL EY ---------- RQR S HP DL D V ----------- LTH GL TLW DLD RE 434
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 197 F hl P TTT F i GG Q E S a LP LR E I IRR L EMA YC QHI G V E F M F I N D L EQ CQ W IRQKF E T P g IMQF T N EE KRTL L AR L VRSTR FE 276
Cdd:PRK12270 435 F -- P VGG F - GG K E R - MK LR D I LGV L RDS YC RTV G I E Y M H I Q D P EQ RR W LQERV E R P - HEKP T R EE QKRI L SK L NAAEA FE 509
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 277 E FLQ R K WSSE KRF G LEG C E V LIP A L KTII D KSS E N G V D Y V IM GM P HRGRLNVLAN VIR K ELE QIF CQ F DSK L E - AADE GS 355
Cdd:PRK12270 510 T FLQ T K YVGQ KRF S LEG G E S LIP L L DAVL D QAA E H G L D E V VI GM A HRGRLNVLAN IVG K PYS QIF RE F EGN L D p RSAQ GS 589
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 356 GDVKYHLG --- MYHR rinr VTDRN I TL SL V ANPSHLEA A DPV VM G KTK A E Q FYCGD - T EG KK V MS ILLHGDAAFAGQG I V 431
Cdd:PRK12270 590 GDVKYHLG aeg TFTQ ---- MFGDE I KV SL A ANPSHLEA V DPV LE G IVR A K Q DRLDK g E EG FT V LP ILLHGDAAFAGQG V V 665
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 432 Y ET FH LS D L PS Y T T H GT V H V VVNNQ I GFTT D P RMA RSS P Y P TDVA RVVN APIFHVN S DDPEAV MY V CKV A A E W R ST FHKD 511
Cdd:PRK12270 666 A ET LN LS Q L RG Y R T G GT I H I VVNNQ V GFTT A P ESS RSS E Y A TDVA KMIQ APIFHVN G DDPEAV VR V ARL A F E Y R QR FHKD 745
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 512 VV V DLVCYRR N GHNE M D E P MF TQPLMY KQ I RKQKP V LQK Y A E L L VSQ G VVNQP E Y E EEISK Y DKIC E EA F ARSKDEK ilh 591
Cdd:PRK12270 746 VV I DLVCYRR R GHNE G D D P SM TQPLMY DL I DAKRS V RKL Y T E A L IGR G DITVE E A E QALRD Y QGQL E RV F NEVREAE --- 822
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 592 i K H wl DSPW P GFFTL D GQ P rs MSCPS T GLTEDI L TH IG NVASSV P v E N FT I H GG L SRI L KT R G EM VKNRTV DWA LA E YM A 671
Cdd:PRK12270 823 - K K -- PPEP P ESVES D QG P -- PAGVD T AVSAEV L ER IG DAHVNL P - E G FT V H PK L KPL L EK R R EM AREGGI DWA FG E LL A 896
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 672 FGSLL K EG IHI RLSGQD VE RGTFS H RH H VL H D QNVDKRTC i P MNH L WPN Q APYT V CN S S LSEY GVL GFE L G FAMAS P N AL 751
Cdd:PRK12270 897 FGSLL L EG TPV RLSGQD SR RGTFS Q RH A VL I D RETGEEYT - P LQN L SDD Q GKFL V YD S L LSEY AAM GFE Y G YSVER P D AL 975
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 752 VLWEAQFGDF H N T AQ C IID Q FI CP G Q AKW VRQN G I VLLLPHG M EG M GP E HSSAR P ERFLQ M C NDD pdvlpdlkeanfdin 831
Cdd:PRK12270 976 VLWEAQFGDF A N G AQ T IID E FI SS G E AKW GQRS G V VLLLPHG Y EG Q GP D HSSAR I ERFLQ L C AEG --------------- 1040
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 832 qlydc N WV V VNC STP G N F FH V LRRQ I L LPF R K PL II FTPKS L LR HPE A R S SFDEMLP G T h F QR VI PE dg P AAQNPEN V K R 911
Cdd:PRK12270 1041 ----- N MT V AQP STP A N Y FH L LRRQ A L SGP R R PL VV FTPKS M LR LKA A V S DVEDFTE G K - F RP VI DD -- P TVDDGAK V R R 1112
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 912 L L F C T GK V YYDL TRE R KARD m VGQV AI T R I EQL S P F P FDL L LKEVQK YPNA - E LA W C QEE HK NQG YYDYVKPR L RTTISR 990
Cdd:PRK12270 1113 V L L C S GK L YYDL AAR R EKDG - RDDT AI V R V EQL Y P L P RAE L REALAR YPNA t E VV W V QEE PA NQG AWPFMALN L PELLPD 1191
890 900 910
....*....|....*....|....*....|....*..
gi 1391723613 991 AKPVWYAG R DPA A A PATG NK K T H LT E L Q R LLD T AF DL 1027
Cdd:PRK12270 1192 GRRLRRVS R PAS A S PATG SA K V H AV E Q Q E LLD E AF AR 1228
2oxo_dh_E1
TIGR00239 2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists ...
49-1025
0e+00
2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists of this thiamine pyrophosphate-binding subunit (E1), dihydrolipoamide succinyltransferase (E2), and lipoamide dehydrogenase (E3). The E1 ortholog from Corynebacterium glutamicum is unusual in having an N-terminal extension that resembles the dihydrolipoamide succinyltransferase (E2) component of 2-oxoglutarate dehydrogenase. [Energy metabolism, TCA cycle]
Pssm-ID: 161785 [Multi-domain]
Cd Length: 929
Bit Score: 987.06
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 49 F LSG TSSN Y V EE M Y CAW L EN P K SV HK SW DIF F RNTNAGA P PGTAYQ SP LPLSRGS LA AV A HAQ S LVEAQ P nv D KL V EDHL 128
Cdd:TIGR00239 1 Y LSG ANQS Y I EE L Y EDY L TD P D SV DA SW RST F DQLPGPG P APDQFH SP TRSYFRR LA KD A SRG S VTISD P -- D TN V SQVK 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 129 AV Q s LIRAY QV RGH HI A K LDPLG iscv NFD dap VTVSSNV DL A vfkerlrmltvgg FYGL D E S DL DKV F HLPTTTFIGGQ 208
Cdd:TIGR00239 79 VL Q - LIRAY RF RGH LH A N LDPLG ---- LKQ --- QDKVPEL DL S ------------- FYGL T E A DL QET F NIGSFVSGKDA 137
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 209 ESA L PLR E IIRR L EMA YC QH IG V E F M F I NDL E QCQ W IR Q KF E TPGIM QF TN EEK RTL L A RL VRSTR FE E FL QR K WSSE KR 288
Cdd:TIGR00239 138 TMK L SNL E LLQA L KQT YC GS IG A E Y M H I TST E EKR W LQ Q RI E SGERA QF NS EEK KRF L S RL TAAEG FE R FL GA K FPGA KR 217
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 289 F G LEG CEV L I P A LK T II DK S SEN G VDY V IM GM P HRGRLNVL A NV IR K EL E Q IF CQ F DS K LEAAD - E G S GDVKYH L G MYHR 367
Cdd:TIGR00239 218 F S LEG LDA L V P M LK E II RH S VNS G TRD V VL GM A HRGRLNVL V NV LG K PP E D IF SE F AG K HKSHL p D G T GDVKYH M G RFSS 297
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 368 RIN r VTDRNIT L S L VA NPSHLE AAD PVV M G K T K A EQFYCG D - T E GK KV MS IL L HGDAAFAGQG I V Y ET FHL S D L PS Y TTH 446
Cdd:TIGR00239 298 DFT - TDGKLVH L A L AF NPSHLE IVS PVV I G S T R A RLDRLN D s P E ST KV LA IL I HGDAAFAGQG V V Q ET LNM S K L RG Y SVG 376
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 447 GT V H VVV NNQIGFTT D P RM ARS S PY PT D V A RVVN APIFHVN S DDPEAV MYVCKV A A E W R S TF HK DV VV DLV C YRR N GHNE 526
Cdd:TIGR00239 377 GT I H III NNQIGFTT N P LD ARS T PY CS D L A KMIQ APIFHVN A DDPEAV AFATRL A V E Y R N TF KR DV FI DLV G YRR H GHNE 456
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 527 M DEP MF TQPLMY KQ I R K QKPVLQK YA EL LVS Q GV VN qpey EE EISKYDKICEE A FARSKD e KILHIKHWLDSPWPGFFT L 606
Cdd:TIGR00239 457 A DEP SA TQPLMY QK I K K HPTPRKV YA DK LVS E GV AT ---- EE DVTEMVNLYRD A LEAADC - VVPSWREMNTASFTWSPE L 531
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 607 D g QPRSMSC P ST g LTEDI L THIGNVA S S VP v E NFTI H GGLSR I LKT R GEMVK -- NRTV DW AL AE YM AF GS L LKE GI HI RL 684
Cdd:TIGR00239 532 N - HEWDEEY P NK - VEMKR L QELAKRI S E VP - E GVEM H SRVAK I YFD R TKAMA ag EKLF DW GG AE NL AF AT L VDD GI PV RL 608
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 685 SG Q D V ERGTF SH RH H VLHDQ N v DKR T CI P MN HL WPN Q APYT V C NS S LSE YG VLGFE L G F A MA SP NA LV L WEAQFGDF H N T 764
Cdd:TIGR00239 609 SG E D S ERGTF FQ RH A VLHDQ S - NGS T YT P LQ HL HNG Q GAFR V W NS V LSE ES VLGFE Y G Y A TT SP RT LV I WEAQFGDF A N G 687
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 765 AQ CI IDQFI CP G QA KW VRQN G I V L LLPHG M EG M GPEHSS A R P ERFLQ MCNDD pdvlpdlkeanfdinqlydc N WV V VNCS 844
Cdd:TIGR00239 688 AQ VV IDQFI SS G EQ KW GQMS G L V M LLPHG Y EG Q GPEHSS G R L ERFLQ LAAEQ -------------------- N MQ V CVPT 747
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 845 TP GNF FH V LRRQ I L LPF R K PL IIFT PKSLLRHP E A R SS FD E MLP GT h FQ R VI P -- E DGPAAQN PE N VKRL LF C T GKVYYD 922
Cdd:TIGR00239 748 TP AQV FH I LRRQ A L RGM R R PL VVMS PKSLLRHP L A V SS LE E LAE GT - FQ P VI G ei E ESGLSLD PE G VKRL VL C S GKVYYD 826
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 923 L t R E RKARDMVGQ VAI T RIEQL S PFP FDLLLKEV Q K YPN - A E LA WCQEE HK N Q G YYD Y VK P R LR TT I SRAKP V W YAGR DP 1001
Cdd:TIGR00239 827 L - H E QRRKNGQKD VAI V RIEQL Y PFP HKAVKEVL Q Q YPN l K E IV WCQEE PL N M G AWY Y SQ P H LR EV I PEGVS V R YAGR PA 905
970 980
....*....|....*....|....
gi 1391723613 1002 A A A PA T G NKKT H LTEL Q R LL DT A F 1025
Cdd:TIGR00239 906 S A S PA V G YMSL H QKQQ Q D LL ND A L 929
TPP_E1_OGDC_like
cd02016 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed ...
275-538
2.30e-179
Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of the tricarboxylic acid cycle.
Pssm-ID: 238974 [Multi-domain]
Cd Length: 265
Bit Score: 522.09
E-value: 2.30e-179
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 275 FE E FL QR K WSSE KRFGLEG C E V LIPAL KTI ID KSS E N GV DY V IM GM P HRGRLNVLANV IR K E LEQIF CQ F DS K L E AAD -- 352
Cdd:cd02016 1 FE Q FL AT K FPGQ KRFGLEG A E S LIPAL DEL ID RAA E L GV EE V VI GM A HRGRLNVLANV LG K P LEQIF SE F EG K S E FPE dd 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 353 EGSGDVKYHLG MYHR R INRV t DRNIT LSL VA NPSHLEA AD PVVMGKT K A E Q F Y C GD T E GK KV MS IL L HGDAAFAGQG I VY 432
Cdd:cd02016 81 EGSGDVKYHLG YSSD R KTPS - GKKVH LSL AP NPSHLEA VN PVVMGKT R A K Q D Y R GD G E RD KV LP IL I HGDAAFAGQG V VY 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 433 ET FH LS D LP S YTT H GT V H V VVNNQIGFTTDPR MA RSSPY P TDVA RVVN APIFHVN S DDPEAV MYVCKV A A E W R ST F H KDV 512
Cdd:cd02016 160 ET LN LS N LP G YTT G GT I H I VVNNQIGFTTDPR DS RSSPY C TDVA KMIG APIFHVN G DDPEAV VRATRL A L E Y R QK F K KDV 239
250 260
....*....|....*....|....*.
gi 1391723613 513 V V DLVCYRR N GHNE M DEP M FTQPLMY 538
Cdd:cd02016 240 V I DLVCYRR H GHNE L DEP S FTQPLMY 265
E1_dh
pfam00676 Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family ...
267-593
8.69e-112
Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family includes pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and 2-oxoisovalerate dehydrogenase.
Pssm-ID: 395548 [Multi-domain]
Cd Length: 300
Bit Score: 348.16
E-value: 8.69e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 267 A R LVRST R F E EFLQRKWSSEKRF G LEGCEVLIP A LKTI I DKSS E N G v DY V I M G mp H R GRL N V LA NVIR ke LE Q IF CQFDS 346
Cdd:pfam00676 1 R R MMTLR R M E DARDALYKRQGIR G FYHLYAGQE A AQVG I AAAL E P G - DY I I P G -- Y R DHG N L LA RGLS -- LE E IF AELYG 75
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 347 KLE aad E G S G DVKY hl G M Y HRRI NR VTDR N IT L SLVAN pshl EA A DPVVMG K T kaeqfycgdt E GKK VMS I L L H GD A A f A 426
Cdd:pfam00676 76 RVA --- K G K G GSMH -- G Y Y GAKG NR FYGG N GI L GAQVP ---- LG A GIALAA K Y ---------- R GKK EVA I T L Y GD G A - A 135
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 427 G QG IVY E TFHLSD L PSYTT hgt VH V VV NNQ I G FT T DPRM A RS S PYPT D V AR VVNA P IF HV NSD DP E AV MYVC K V AAE WRS 506
Cdd:pfam00676 136 N QG DFF E GLNFAA L WKLPV --- IF V CE NNQ Y G IS T PAER A SA S TTYA D R AR GYGI P GL HV DGM DP L AV YQAS K F AAE RAR 212
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 507 T FHKDVVVD LV C YR RN GH NEM D E P MFTQ - PLM Y KQI RK Q K PVL Q KYA E L LVS Q GV VNQP E YEEEISKYD K IC EEAF ARSK 585
Cdd:pfam00676 213 T GKGPFLIE LV T YR YG GH SMS D D P STYR t RDE Y EEV RK K K DPI Q RFK E H LVS K GV WSEE E LKAIEKEVR K EV EEAF KKAE 292
....*...
gi 1391723613 586 DEKIL H IK 593
Cdd:pfam00676 293 SAPEP H PE 300
OxoGdeHyase_C
pfam16870 2-oxoglutarate dehydrogenase C-terminal; OxoGdeHyase_C is a family found immediately ...
880-1025
1.66e-80
2-oxoglutarate dehydrogenase C-terminal; OxoGdeHyase_C is a family found immediately C-terminal to Transket_pyr, pfam02779. It is found at the C-terminus of 2-oxoglutarate dehydrogenase.
Pssm-ID: 465289 [Multi-domain]
Cd Length: 147
Bit Score: 258.14
E-value: 1.66e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 880 RSS FD E ML PGTHFQRVIP EDG P A a QN PE N VKR LLF C T GKVYYDL TR ER KA R DMVGQ VAI T RIEQL S PFPFDLL LK E VQ KY 959
Cdd:pfam16870 1 RSS LE E FT PGTHFQRVIP DPE P L - VD PE K VKR VVL C S GKVYYDL LK ER EE R GGIKD VAI V RIEQL Y PFPFDLL KE E LD KY 79
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1391723613 960 PNA - E LA WCQEE H KNQG YYDY V K PRL R T TISRA - KPVW YAGR D P A A A PATG N K KT HL T E LQR LLD T AF 1025
Cdd:pfam16870 80 PNA a E IV WCQEE P KNQG AWSF V Q PRL E T VLNET g HRLR YAGR P P S A S PATG S K SV HL A E QEA LLD D AF 147
Transket_pyr
pfam02779 Transketolase, pyrimidine binding domain; This family includes transketolase enzymes, pyruvate ...
660-875
3.38e-53
Transketolase, pyrimidine binding domain; This family includes transketolase enzymes, pyruvate dehydrogenases, and branched chain alpha-keto acid decarboxylases.
Pssm-ID: 460692 [Multi-domain]
Cd Length: 174
Bit Score: 183.52
E-value: 3.38e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 660 RTVDWAL A EYM A FGS L L K EGIHIRLS G Q D VER GTF SHRHHV LH D qnvdkrtcipmnhlwpn Q APYT V CNSSLS E YGVL GF 739
Cdd:pfam02779 1 KKIATRK A SGE A LAE L A K RDPRVVGG G A D LAG GTF TVTKGL LH P ----------------- Q GAGR V IDTGIA E QAMV GF 63
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 740 EL G F A MAS P N a L VLW EA Q F G DF H N taqc II D QF I CP G Q A KWVRQNG - I V LLL P H G MEGM GP E H S S ARPER FL QMCN ddpd 818
Cdd:pfam02779 64 AN G M A LHG P L - L PPV EA T F S DF L N ---- RA D DA I RH G A A LGKLPVP f V V TRD P I G VGED GP T H Q S VEDLA FL RAIP ---- 134
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1391723613 819 vlpdlkeanfdinqlydc NWV VV NC S TPGNFFHV LR RQ I LLPF RKP LIIFT P KS LLR 875
Cdd:pfam02779 135 ------------------ GLK VV RP S DAAETKGL LR AA I RRDG RKP VVLRL P RQ LLR 173
Transket_pyr
smart00861 Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer ...
728-875
4.24e-22
Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor, such as ribose 5-phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3- phosphate. This enzyme, together with transaldolase, provides a link between the glycolytic and pentose-phosphate pathways. TK requires thiamine pyrophosphate as a cofactor. In most sources where TK has been purified, it is a homodimer of approximately 70 Kd subunits. TK sequences from a variety of eukaryotic and prokaryotic sources show that the enzyme has been evolutionarily conserved. In the peroxisomes of methylotrophic yeast Hansenula polymorpha, there is a highly related enzyme, dihydroxy-acetone synthase (DHAS) (also known as formaldehyde transketolase), which exhibits a very unusual specificity by including formaldehyde amongst its substrates.
Pssm-ID: 214865 [Multi-domain]
Cd Length: 136
Bit Score: 92.93
E-value: 4.24e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 728 NSSLS E YGVL GF EL G F A MA spn A L VLWEAQ F GD F HNT A QCI I DQFIC pgqak WVRQNGIVLLLPH G ME G M - GP E H S S ARP 806
Cdd:smart00861 19 DTGIA E QAMV GF AA G L A LH --- G L RPVVEI F FT F FDR A KDQ I RSAGA ----- SGNVPVVFRHDGG G GV G E d GP T H H S IED 90
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 807 E - RFLQM cnddpdvlpdlkeanfdinqlyd CNWV VV NC S T P GNFFHV LR RQ I LLP f RKPL I IFTP KSL L R 875
Cdd:smart00861 91 E a LLRAI ----------------------- PGLK VV AP S D P AEAKGL LR AA I RDD - GPVV I RLER KSL Y R 136
2-oxogl_dehyd_N
pfam16078 2-oxoglutarate dehydrogenase N-terminus; This domain is found at the N-terminus of ...
47-87
1.26e-15
2-oxoglutarate dehydrogenase N-terminus; This domain is found at the N-terminus of 2-oxoglutarate dehydrogenases.
Pssm-ID: 465008 [Multi-domain]
Cd Length: 41
Bit Score: 71.41
E-value: 1.26e-15
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1391723613 47 EP FLSG TSSN Y V EE M Y CAW L EN P K SV HK SW DIF F R N TNA G A 87
Cdd:pfam16078 1 DS FLSG ANAA Y I EE L Y EQY L KD P S SV DP SW RAY F D N LDD G E 41
TPP_E1_PDC_ADC_BCADC
cd02000 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; ...
411-583
1.12e-11
Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain alpha-keto acid dehydrogenase/2-oxoisovalerate dehydrogenase complex (BCADC). PDC catalyzes the irreversible oxidative decarboxylation of pyruvate to produce acetyl-CoA in the bridging step between glycolysis and the citric acid cycle. ADC participates in the breakdown of acetoin while BCADC participates in the breakdown of branched chain amino acids. BCADC catalyzes the oxidative decarboxylation of 4-methyl-2-oxopentanoate, 3-methyl-2-oxopentanoate and 3-methyl-2-oxobutanoate (branched chain 2-oxo acids derived from the transamination of leucine, valine and isoleucine).
Pssm-ID: 238958 [Multi-domain]
Cd Length: 293
Bit Score: 66.75
E-value: 1.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 411 G KKVMSILLH GD A A f AGQ G IVY E TFHLS --- D LP sytthg TVH V VV NN QIGFT T d P R m A R SSPYPTDVA R VVNA -- P IFH 485
Cdd:cd02000 124 G EDRVAVCFF GD G A - TNE G DFH E ALNFA alw K LP ------ VIF V CE NN GYAIS T - P T - S R QTAGTSIAD R AAAY gi P GIR 194
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391723613 486 V NSD D PE AV MYVC K V A A E W - R ST f HKDVVVDL V C YR RN GH NEM D E P M ftqpl M Y K ----- QIR K QKPVLQKYAEL L VSQ G 559
Cdd:cd02000 195 V DGN D VL AV YEAA K E A V E R a R AG - GGPTLIEA V T YR LG GH STS D D P S ----- R Y R tkeev EEW K KRDPILRLRKY L IEA G 268
170 180
....*....|....*....|....
gi 1391723613 560 VVNQP E YEEEISKYDKIC EEA FAR 583
Cdd:cd02000 269 ILTEE E LAAIEAEVKAEV EEA VEF 292
kgd
PRK12270 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
57-112
1.83e-03
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;
Pssm-ID: 237030 [Multi-domain]
Cd Length: 1228
Bit Score: 42.57
E-value: 1.83e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1391723613 57 Y VEEMY CAW L EN P K SV HK SW DI FF RNTNA G APPGTAYQSPLPLSRG S LA A V A H A QS 112
Cdd:PRK12270 10 L VEEMY QQY L AD P N SV DP SW RE FF ADYGP G STAAPTAAAAAAAAAA S AP A A A P A AK 65
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
