F-box/LRR-repeat protein 18 isoform 3 [Homo sapiens]
Protein Classification
F-box/LRR-repeat protein 18( domain architecture ID 17778604)
F-box/LRR-repeat protein 18 functions as the substrate-recognition component of an SCF (Skp1-cullin-F-box) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||||||
| FBXL18_LRR | pfam19729 | F-box/LRR-repeat protein 18, LRR; This entry represents the leucine-rich repeats (LRR) from ... |
85-669 | 0e+00 | |||||||||
F-box/LRR-repeat protein 18, LRR; This entry represents the leucine-rich repeats (LRR) from F-box/LRR repeat protein 18 (also known as F-box and leucine-rich repeat protein 18, FBXL18), associated with F-box domains. This protein is the substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex through its F-box and the LRR motifs mediate the protein-protein interactions required for the binding of the specific substrates by SCFs complexes. : Pssm-ID: 466163 [Multi-domain] Cd Length: 594 Bit Score: 1154.11 E-value: 0e+00
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| F-box_FBXL18 | cd22128 | F-box domain found in F-box/LRR-repeat protein 18 (FBXL18) and similar proteins; FBXL18, also ... |
28-71 | 2.75e-19 | |||||||||
F-box domain found in F-box/LRR-repeat protein 18 (FBXL18) and similar proteins; FBXL18, also called F-box and leucine-rich repeat protein 18, is a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It promotes glioma progression by promoting K63-linked ubiquitination of Akt. It targets leucine-rich repeat kinase 2 (LRRK2) for proteasomal degradation and attenuates cell toxicity. FBXL18 also regulates apoptosis by mediating ubiquitin-dependent proteasomal degradation of the pro-apoptotic protein FBXL7 that may impact cellular processes involved in cell cycle progression. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. : Pssm-ID: 438900 Cd Length: 44 Bit Score: 81.33 E-value: 2.75e-19
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| Name | Accession | Description | Interval | E-value | |||||||||
| FBXL18_LRR | pfam19729 | F-box/LRR-repeat protein 18, LRR; This entry represents the leucine-rich repeats (LRR) from ... |
85-669 | 0e+00 | |||||||||
F-box/LRR-repeat protein 18, LRR; This entry represents the leucine-rich repeats (LRR) from F-box/LRR repeat protein 18 (also known as F-box and leucine-rich repeat protein 18, FBXL18), associated with F-box domains. This protein is the substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex through its F-box and the LRR motifs mediate the protein-protein interactions required for the binding of the specific substrates by SCFs complexes. Pssm-ID: 466163 [Multi-domain] Cd Length: 594 Bit Score: 1154.11 E-value: 0e+00
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| F-box_FBXL18 | cd22128 | F-box domain found in F-box/LRR-repeat protein 18 (FBXL18) and similar proteins; FBXL18, also ... |
28-71 | 2.75e-19 | |||||||||
F-box domain found in F-box/LRR-repeat protein 18 (FBXL18) and similar proteins; FBXL18, also called F-box and leucine-rich repeat protein 18, is a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It promotes glioma progression by promoting K63-linked ubiquitination of Akt. It targets leucine-rich repeat kinase 2 (LRRK2) for proteasomal degradation and attenuates cell toxicity. FBXL18 also regulates apoptosis by mediating ubiquitin-dependent proteasomal degradation of the pro-apoptotic protein FBXL7 that may impact cellular processes involved in cell cycle progression. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438900 Cd Length: 44 Bit Score: 81.33 E-value: 2.75e-19
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| F-box-like | pfam12937 | F-box-like; This is an F-box-like family. |
33-68 | 3.20e-05 | |||||||||
F-box-like; This is an F-box-like family. Pssm-ID: 463757 [Multi-domain] Cd Length: 45 Bit Score: 41.70 E-value: 3.20e-05
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| FBOX | smart00256 | A Receptor for Ubiquitination Targets; |
33-70 | 6.94e-04 | |||||||||
A Receptor for Ubiquitination Targets; Pssm-ID: 197608 Cd Length: 41 Bit Score: 37.80 E-value: 6.94e-04
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| Name | Accession | Description | Interval | E-value | |||||||||
| FBXL18_LRR | pfam19729 | F-box/LRR-repeat protein 18, LRR; This entry represents the leucine-rich repeats (LRR) from ... |
85-669 | 0e+00 | |||||||||
F-box/LRR-repeat protein 18, LRR; This entry represents the leucine-rich repeats (LRR) from F-box/LRR repeat protein 18 (also known as F-box and leucine-rich repeat protein 18, FBXL18), associated with F-box domains. This protein is the substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex through its F-box and the LRR motifs mediate the protein-protein interactions required for the binding of the specific substrates by SCFs complexes. Pssm-ID: 466163 [Multi-domain] Cd Length: 594 Bit Score: 1154.11 E-value: 0e+00
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| F-box_FBXL18 | cd22128 | F-box domain found in F-box/LRR-repeat protein 18 (FBXL18) and similar proteins; FBXL18, also ... |
28-71 | 2.75e-19 | |||||||||
F-box domain found in F-box/LRR-repeat protein 18 (FBXL18) and similar proteins; FBXL18, also called F-box and leucine-rich repeat protein 18, is a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It promotes glioma progression by promoting K63-linked ubiquitination of Akt. It targets leucine-rich repeat kinase 2 (LRRK2) for proteasomal degradation and attenuates cell toxicity. FBXL18 also regulates apoptosis by mediating ubiquitin-dependent proteasomal degradation of the pro-apoptotic protein FBXL7 that may impact cellular processes involved in cell cycle progression. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438900 Cd Length: 44 Bit Score: 81.33 E-value: 2.75e-19
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| F-box-like | pfam12937 | F-box-like; This is an F-box-like family. |
33-68 | 3.20e-05 | |||||||||
F-box-like; This is an F-box-like family. Pssm-ID: 463757 [Multi-domain] Cd Length: 45 Bit Score: 41.70 E-value: 3.20e-05
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| F-box_ScMFB1-like | cd22146 | F-box domain found in Saccharomyces cerevisiae mitochondrial F-box protein MFB1 (ScMFB1) and ... |
28-70 | 5.17e-05 | |||||||||
F-box domain found in Saccharomyces cerevisiae mitochondrial F-box protein MFB1 (ScMFB1) and similar proteins; ScMFB1 is a novel mitochondria-associated F-box protein that functions to increase mitochondrial connectivity in yeast. ScMFB1 acts as a key component of a Skp1-Cdc53/Cullin-F-box protein (SCF) ubiquitin ligase complex machinery that regulates mitochondrial dynamics throughout the yeast's entire life cycle. It interacts with Skp1p in an F-box-dependent manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438917 Cd Length: 42 Bit Score: 40.70 E-value: 5.17e-05
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| F-box_FBXO6-like | cd22168 | F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily ... |
33-56 | 2.20e-04 | |||||||||
F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily includes FBXO6 and FBXO44. FBXO6, also called FBX6, F-box protein that recognizes sugar chains 2 (FBS2), or F-box/G-domain protein 2 (FBG2), is a substrate-recognition component of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. It is involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins, by recognizing and binding sugar chains on unfolded glycoproteins that are retro-translocated into the cytosol and promoting their ubiquitination and subsequent degradation. FBXO6 can recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. It also recognizes sulfated glycans. FBXO6 is involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. FBXO44, also called FBXO6A, FBX44, or F-box/G-domain protein 3 (FBG3), is a substrate-recognition component of an SCF-type E3 ubiquitin ligase complex. It interacts with SKP1 and CUL1. FBXO44 mediates BRCA1 ubiquitination and degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438939 [Multi-domain] Cd Length: 82 Bit Score: 40.34 E-value: 2.20e-04
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| FBOX | smart00256 | A Receptor for Ubiquitination Targets; |
33-70 | 6.94e-04 | |||||||||
A Receptor for Ubiquitination Targets; Pssm-ID: 197608 Cd Length: 41 Bit Score: 37.80 E-value: 6.94e-04
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| F-box_SF | cd09917 | F-box domain superfamily; This short domain is commonly found at the N-terminus of various ... |
33-63 | 1.61e-03 | |||||||||
F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures. Pssm-ID: 438852 Cd Length: 35 Bit Score: 36.65 E-value: 1.61e-03
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| F-box_FBXO24 | cd22098 | F-box domain found in F-box only protein 24 (FBXO24) and similar proteins; FBXO24, also called ... |
27-63 | 4.99e-03 | |||||||||
F-box domain found in F-box only protein 24 (FBXO24) and similar proteins; FBXO24, also called FBX24, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It recognizes deacetylated nucleoside diphosphate kinase A (NDPK-A) to enhance its degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438870 Cd Length: 47 Bit Score: 35.38 E-value: 4.99e-03
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| F-box_FBA | cd22083 | F-box domain found in the F-box associated (FBA) family of F-box proteins; The F-box ... |
32-57 | 7.62e-03 | |||||||||
F-box domain found in the F-box associated (FBA) family of F-box proteins; The F-box associated (FBA) family is composed of FBXO2, FBXO6, FBXO17, FBXO27, and FBXO44, which contain a conserved G domain that mediates substrate binding. Members of this family play diverse roles in glycoprotein quality control. They bind high mannose and sulfated glycoproteins, with one FBA protein, FBXO44, failing to bind any glycans on the tested arrays. FBA proteins are components of canonical SCF (Skp1, Cullin1, and Rbx1) complexes, yet FBXO2 bound very little Cullin1, suggesting that FBXO2 may exist primarily as a heterodimer with Skp1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438855 Cd Length: 37 Bit Score: 34.67 E-value: 7.62e-03
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