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Conserved domains on  [gi|1387845338|ref|NP_001350074|]
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nicotinate phosphoribosyltransferase isoform 3 [Homo sapiens]

Protein Classification

beta/alpha barrel domain-containing protein( domain architecture ID 229392)

beta/alpha barrel domain-containing protein belongs to a large superfamily with a wide variety of enzymatic functions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIM super family cl21457
TIM-like beta/alpha barrel domains; A large family of domains similar to triose phosphate ...
 15-498 0e+00

TIM-like beta/alpha barrel domains; A large family of domains similar to triose phosphate isomerase (TIM) which, in general, share an eight beta/alpha closed barrel structure.


The actual alignment was detected with superfamily member PLN02885:

Pssm-ID: 473867 [Multi-domain]  Cd Length: 545  Bit Score: 559.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338  15 PLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPDTDPAFFE 94
Cdd:PLN02885   12 PLLTDLYQFTMAYAYWKAGKHLDRAVFDLFFRKNPFGGEYTVFAGLEECLRFIANFKFTDDDIDFLRSVMPSGCEDAFFD 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338  95 HLRALDCSEVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGPEKRLLEMGLRRAQ 174
Cdd:PLN02885   92 YLRGLDCSDVEVYAIPEGSVVFPRVPLMRIEGPLAVVQLLETTFLTLVNYASLVATNAARHRLVAGKSKVLLEFGLRRAQ 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFSGSEVPPDPMLAPAAGEGPGVDLAAKAQVWLE--Q 252
Cdd:PLN02885  172 GPDGGISASKYCYLGGFDATSNVEAGRLFGIPVRGTHSHAFVSSYMGLDEIVDKTLRSADGSSVCEDFVSLVQEWLSklQ 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 253 VCAHLGLGVQEPHPGERAAFVAYALAFPRAFQGLLDTYSVWRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQQAQEIR 332
Cdd:PLN02885  252 ESSSLRGVFSETNQSELAAFTSYALAFPNSFLALVDTYDVMKSGIPNFCAVALALNDLGYKAVGIRLDSGDLAYLSLEAR 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 333 KVFRAAAAQFQVPWLESVLIVVSNNIDEEALARLAQE---------------------------LVAVGGQPRMKLTEDP 385
Cdd:PLN02885  332 KFFRTIEEELGVPGFGKMSITASNDINEETLDALNKQgheidafgigthlvtcyaqpalgcvykLVEINGQPRIKLSEDV 411

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 386 EKQTLPGSKAAFRLLGSDGSPLMDMLQLAEEPVPQAGQelRVW---PPGAQEPCTVRPAQVEPLLRlCLQQGQLCEP--- 459
Cdd:PLN02885  412 EKVTIPCKKRCYRLYGKEGYPLVDLMTGENEPPPKVGE--RILcrhPFNESKRAYVVPQRVEELLK-CYWDGSSGKPree 488

                         490       500       510
                  ....*....|....*....|....*....|....*....
gi 1387845338 460 LPSLAESRALAQLSLSRLSPEHRRLRSPAQYQVVLSERL 498
Cdd:PLN02885  489 LPSLKEIRERCMKQLERMRPDHMRRLNPTPYKVSVSAKL 527
 
Name Accession Description Interval E-value
PLN02885 PLN02885
nicotinate phosphoribosyltransferase
 15-498 0e+00

nicotinate phosphoribosyltransferase


Pssm-ID: 178473 [Multi-domain]  Cd Length: 545  Bit Score: 559.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338  15 PLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPDTDPAFFE 94
Cdd:PLN02885   12 PLLTDLYQFTMAYAYWKAGKHLDRAVFDLFFRKNPFGGEYTVFAGLEECLRFIANFKFTDDDIDFLRSVMPSGCEDAFFD 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338  95 HLRALDCSEVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGPEKRLLEMGLRRAQ 174
Cdd:PLN02885   92 YLRGLDCSDVEVYAIPEGSVVFPRVPLMRIEGPLAVVQLLETTFLTLVNYASLVATNAARHRLVAGKSKVLLEFGLRRAQ 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFSGSEVPPDPMLAPAAGEGPGVDLAAKAQVWLE--Q 252
Cdd:PLN02885  172 GPDGGISASKYCYLGGFDATSNVEAGRLFGIPVRGTHSHAFVSSYMGLDEIVDKTLRSADGSSVCEDFVSLVQEWLSklQ 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 253 VCAHLGLGVQEPHPGERAAFVAYALAFPRAFQGLLDTYSVWRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQQAQEIR 332
Cdd:PLN02885  252 ESSSLRGVFSETNQSELAAFTSYALAFPNSFLALVDTYDVMKSGIPNFCAVALALNDLGYKAVGIRLDSGDLAYLSLEAR 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 333 KVFRAAAAQFQVPWLESVLIVVSNNIDEEALARLAQE---------------------------LVAVGGQPRMKLTEDP 385
Cdd:PLN02885  332 KFFRTIEEELGVPGFGKMSITASNDINEETLDALNKQgheidafgigthlvtcyaqpalgcvykLVEINGQPRIKLSEDV 411

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 386 EKQTLPGSKAAFRLLGSDGSPLMDMLQLAEEPVPQAGQelRVW---PPGAQEPCTVRPAQVEPLLRlCLQQGQLCEP--- 459
Cdd:PLN02885  412 EKVTIPCKKRCYRLYGKEGYPLVDLMTGENEPPPKVGE--RILcrhPFNESKRAYVVPQRVEELLK-CYWDGSSGKPree 488

                         490       500       510
                  ....*....|....*....|....*....|....*....
gi 1387845338 460 LPSLAESRALAQLSLSRLSPEHRRLRSPAQYQVVLSERL 498
Cdd:PLN02885  489 LPSLKEIRERCMKQLERMRPDHMRRLNPTPYKVSVSAKL 527
NAPRTase_put TIGR01513
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of ...
 15-498 0e+00

putative nicotinate phosphoribosyltransferase; A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This model represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]


Pssm-ID: 273666 [Multi-domain]  Cd Length: 443  Bit Score: 548.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338  15 PLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVlpPDTDPAFFE 94
Cdd:TIGR01513   1 ALLTDLYELTMAQGYFREGKANQPAVFEVFFRKLPFGRGYAVFAGLEDLLEFLENFRFDAEDIEYLASL--GIFDDAFLD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338  95 HLRALDCSeVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGPEKrLLEMGLRRAQ 174
Cdd:TIGR01513  79 YLREFRFS-GTVRALPEGSLVFPNEPLLQVEGPLIEAQLLETLVLNIINFQTLIATKAARIVLAAGGKP-LLEFGLRRAQ 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFsgsevppdpmlapaagegpgvdlaakaqvwleqvc 254
Cdd:TIGR01513 157 GPDAALKAARAAYIGGADGTSNVLAGRLYGIPVSGTMAHSFVMSF----------------------------------- 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 255 ahlglgvqephPGERAAFVAYALAFPRAFQGLLDTYSVWRSGLPNFLAVALALGELGYrAVGVRLDSGDLLQQAQEIRKV 334
Cdd:TIGR01513 202 -----------DNELAAFRAYAKLYPKATVLLVDTYDTLRSGLPNAIAVAKELGEQGK-VVGVRIDSGDLLYLSKQARKQ 269

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 335 FRAAAaqfqvpwLESVLIVVSNNIDEEALARLAQE---------------------------LVAVGGQPRMKLTEDPEK 387
Cdd:TIGR01513 270 LDAAG-------LTQVKIVVSNDLDENSIAALKAEgapidvygvgtslvtasdapalggvykLVAYEGRPVMKLSENPEK 342

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 388 QTLPGSKAAFRLLGSDGSPLMDMLQLAEEPVPQAgqelrvwppgAQEPCTVRPAQVEPLLRLCLQQGQLCEPLPSLAESR 467
Cdd:TIGR01513 343 STLPGRKQVFRLYDATGKFLGDELTLADEPIEDL----------NQEKCTPVFAPVEPLLRLVMKNGQRVRPLPSLAEIR 412

                         490       500       510
                  ....*....|....*....|....*....|.
gi 1387845338 468 ALAQLSLSRLSPEHRRLRSPAQYQVVLSERL 498
Cdd:TIGR01513 413 ARAREQLSKLPPEYLRLLNPHVYPVSLSPRL 443
NAPRTase_A cd01570
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ...
 15-369 4.14e-144

Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).


Pssm-ID: 238804 [Multi-domain]  Cd Length: 327  Bit Score: 416.59  E-value: 4.14e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338  15 PLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPdtDPAFFE 94
Cdd:cd01570     1 ALLTDLYQLTMAQAYWKEGKHNKPAVFELFFRKLPFGGGYAVFAGLEELLEYLENFRFTEEDIDYLRSLGIF--DEEFLD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338  95 HLRALDcSEVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGPeKRLLEMGLRRAQ 174
Cdd:cd01570    79 YLRGFR-FTGTIYAIPEGEVVFPNEPLLTVEGPLIEAQLLETLLLNLINFQTLIATKAARVRLAAGG-RPLLEFGLRRAQ 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFsgsevppdpmlapaagegpgvdlaakaqvwleqvc 254
Cdd:cd01570   157 GPDAALSAARAAYIGGFDGTSNVLAGKLYGIPVSGTMAHSFVQAF----------------------------------- 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 255 ahlglgvqephPGERAAFVAYALAFPRAFQGLLDTYSVWRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQQAQEIRKV 334
Cdd:cd01570   202 -----------DDELAAFRAFAEAYPDNFTLLVDTYDTLRSGLPNAIAVAKELGALGYRLVGVRIDSGDLAYLSKEARKM 270

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1387845338 335 FRAAAaqfqvpwLESVLIVVSNNIDEEALARLAQE 369
Cdd:cd01570   271 LDEAG-------LTKVKIVASNDLDEYTIAALNAQ 298
PncB COG1488
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ...
 16-505 1.24e-120

Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis


Pssm-ID: 441097 [Multi-domain]  Cd Length: 445  Bit Score: 361.39  E-value: 1.24e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338  16 LLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVlpPDTDPAFFEH 95
Cdd:COG1488     6 LLTDLYKLTMAQAYLPEGTANRRAVFELFFRRLPFGRGYVVFAGLQRFLKYLENLRFTEEDIAYLRSL--GVFDEDFLDY 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338  96 LRALDCSeVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGpEKRLLEMGLRRAQG 175
Cdd:COG1488    84 LADFRFP-GDIRAVPEGTVVFPGEPLLTVEGTLPEAQLLETLLLNILNYPTLIATKAARIVQAAG-GRPLHDFGLRRAHG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 176 PDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSfsgsevppdpmlapaagegpgvdlaakaqvwleqvca 255
Cdd:COG1488   162 LEAAVAAARAAYLAGFAGTSNVLAGRYYGIPSVGTMAHSFVQA------------------------------------- 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 256 hlglgvqepHPGERAAFVAYALAFPRAFQGLLDTYSVWrSGLPNflAVALAlGELG--YRAVGVRLDSGDLLQQAQEIRK 333
Cdd:COG1488   205 ---------HDDELEAFRAFAEAYPDGTTLLVDTYDTL-SGVPN--AIELA-KELLarGGLLGIRLDSGDLAYLSKQARE 271

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 334 VFRAAAaqfqvpwLESVLIVVSNNIDEEALARLAQE---------------------------LVAVGG----QPRMKLT 382
Cdd:COG1488   272 LLDEAG-------LPDVRIIASDDLDEYRIAALLEQgapidvfgvgtrlvtssdrptlgfvykLVAVEGdgewRPVIKLS 344

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 383 EDPEKQTLPGSKAAFRlLGSDGSPLMDMLQLAEEPVPQAGqelrvwppgaqepctvrpaqvEPLLRLCLQQGQLCEPLPS 462
Cdd:COG1488   345 ETPGKKSKPGRKQVYR-RDEDGKATADLVALEDEPLPGEP---------------------EPLLVPVFRDGKLVYELPS 402

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|...
gi 1387845338 463 LAESRALAQLSLSRLSPEHRRLRSPAQYQVVLSERLQALVNSL 505
Cdd:COG1488   403 LEEIRERAAAQLAELPEELKRLRNPPAYPVDLSEALWDLKEQL 445
NAPRTase_N pfam17767
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate ...
 16-143 1.19e-45

Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This is the N-terminal domain of the enzyme.


Pssm-ID: 465494 [Multi-domain]  Cd Length: 125  Bit Score: 155.75  E-value: 1.19e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338  16 LLTDLYQATMALGYWRAGRARDAaEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPdTDPAFFEH 95
Cdd:pfam17767   1 LDTDLYKLTMAQAYFKNGPDVQV-VFEFFNRTNPFGGLYAVFAGLEEQIEFLENLRFTEEEIEYLRRSLPY-FKPDFLDY 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1387845338  96 LRALDCSEVTVrALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVS 143
Cdd:pfam17767  79 LRNFRFDPSIV-AVPEGEVVFPGEPLLRIEGPWLETILLETPLLAIVN 125
 
Name Accession Description Interval E-value
PLN02885 PLN02885
nicotinate phosphoribosyltransferase
 15-498 0e+00

nicotinate phosphoribosyltransferase


Pssm-ID: 178473 [Multi-domain]  Cd Length: 545  Bit Score: 559.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338  15 PLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPDTDPAFFE 94
Cdd:PLN02885   12 PLLTDLYQFTMAYAYWKAGKHLDRAVFDLFFRKNPFGGEYTVFAGLEECLRFIANFKFTDDDIDFLRSVMPSGCEDAFFD 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338  95 HLRALDCSEVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGPEKRLLEMGLRRAQ 174
Cdd:PLN02885   92 YLRGLDCSDVEVYAIPEGSVVFPRVPLMRIEGPLAVVQLLETTFLTLVNYASLVATNAARHRLVAGKSKVLLEFGLRRAQ 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFSGSEVPPDPMLAPAAGEGPGVDLAAKAQVWLE--Q 252
Cdd:PLN02885  172 GPDGGISASKYCYLGGFDATSNVEAGRLFGIPVRGTHSHAFVSSYMGLDEIVDKTLRSADGSSVCEDFVSLVQEWLSklQ 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 253 VCAHLGLGVQEPHPGERAAFVAYALAFPRAFQGLLDTYSVWRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQQAQEIR 332
Cdd:PLN02885  252 ESSSLRGVFSETNQSELAAFTSYALAFPNSFLALVDTYDVMKSGIPNFCAVALALNDLGYKAVGIRLDSGDLAYLSLEAR 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 333 KVFRAAAAQFQVPWLESVLIVVSNNIDEEALARLAQE---------------------------LVAVGGQPRMKLTEDP 385
Cdd:PLN02885  332 KFFRTIEEELGVPGFGKMSITASNDINEETLDALNKQgheidafgigthlvtcyaqpalgcvykLVEINGQPRIKLSEDV 411

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 386 EKQTLPGSKAAFRLLGSDGSPLMDMLQLAEEPVPQAGQelRVW---PPGAQEPCTVRPAQVEPLLRlCLQQGQLCEP--- 459
Cdd:PLN02885  412 EKVTIPCKKRCYRLYGKEGYPLVDLMTGENEPPPKVGE--RILcrhPFNESKRAYVVPQRVEELLK-CYWDGSSGKPree 488

                         490       500       510
                  ....*....|....*....|....*....|....*....
gi 1387845338 460 LPSLAESRALAQLSLSRLSPEHRRLRSPAQYQVVLSERL 498
Cdd:PLN02885  489 LPSLKEIRERCMKQLERMRPDHMRRLNPTPYKVSVSAKL 527
NAPRTase_put TIGR01513
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of ...
 15-498 0e+00

putative nicotinate phosphoribosyltransferase; A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This model represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]


Pssm-ID: 273666 [Multi-domain]  Cd Length: 443  Bit Score: 548.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338  15 PLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVlpPDTDPAFFE 94
Cdd:TIGR01513   1 ALLTDLYELTMAQGYFREGKANQPAVFEVFFRKLPFGRGYAVFAGLEDLLEFLENFRFDAEDIEYLASL--GIFDDAFLD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338  95 HLRALDCSeVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGPEKrLLEMGLRRAQ 174
Cdd:TIGR01513  79 YLREFRFS-GTVRALPEGSLVFPNEPLLQVEGPLIEAQLLETLVLNIINFQTLIATKAARIVLAAGGKP-LLEFGLRRAQ 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFsgsevppdpmlapaagegpgvdlaakaqvwleqvc 254
Cdd:TIGR01513 157 GPDAALKAARAAYIGGADGTSNVLAGRLYGIPVSGTMAHSFVMSF----------------------------------- 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 255 ahlglgvqephPGERAAFVAYALAFPRAFQGLLDTYSVWRSGLPNFLAVALALGELGYrAVGVRLDSGDLLQQAQEIRKV 334
Cdd:TIGR01513 202 -----------DNELAAFRAYAKLYPKATVLLVDTYDTLRSGLPNAIAVAKELGEQGK-VVGVRIDSGDLLYLSKQARKQ 269

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 335 FRAAAaqfqvpwLESVLIVVSNNIDEEALARLAQE---------------------------LVAVGGQPRMKLTEDPEK 387
Cdd:TIGR01513 270 LDAAG-------LTQVKIVVSNDLDENSIAALKAEgapidvygvgtslvtasdapalggvykLVAYEGRPVMKLSENPEK 342

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 388 QTLPGSKAAFRLLGSDGSPLMDMLQLAEEPVPQAgqelrvwppgAQEPCTVRPAQVEPLLRLCLQQGQLCEPLPSLAESR 467
Cdd:TIGR01513 343 STLPGRKQVFRLYDATGKFLGDELTLADEPIEDL----------NQEKCTPVFAPVEPLLRLVMKNGQRVRPLPSLAEIR 412

                         490       500       510
                  ....*....|....*....|....*....|.
gi 1387845338 468 ALAQLSLSRLSPEHRRLRSPAQYQVVLSERL 498
Cdd:TIGR01513 413 ARAREQLSKLPPEYLRLLNPHVYPVSLSPRL 443
NAPRTase_A cd01570
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ...
 15-369 4.14e-144

Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).


Pssm-ID: 238804 [Multi-domain]  Cd Length: 327  Bit Score: 416.59  E-value: 4.14e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338  15 PLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPdtDPAFFE 94
Cdd:cd01570     1 ALLTDLYQLTMAQAYWKEGKHNKPAVFELFFRKLPFGGGYAVFAGLEELLEYLENFRFTEEDIDYLRSLGIF--DEEFLD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338  95 HLRALDcSEVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGPeKRLLEMGLRRAQ 174
Cdd:cd01570    79 YLRGFR-FTGTIYAIPEGEVVFPNEPLLTVEGPLIEAQLLETLLLNLINFQTLIATKAARVRLAAGG-RPLLEFGLRRAQ 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFsgsevppdpmlapaagegpgvdlaakaqvwleqvc 254
Cdd:cd01570   157 GPDAALSAARAAYIGGFDGTSNVLAGKLYGIPVSGTMAHSFVQAF----------------------------------- 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 255 ahlglgvqephPGERAAFVAYALAFPRAFQGLLDTYSVWRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQQAQEIRKV 334
Cdd:cd01570   202 -----------DDELAAFRAFAEAYPDNFTLLVDTYDTLRSGLPNAIAVAKELGALGYRLVGVRIDSGDLAYLSKEARKM 270

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1387845338 335 FRAAAaqfqvpwLESVLIVVSNNIDEEALARLAQE 369
Cdd:cd01570   271 LDEAG-------LTKVKIVASNDLDEYTIAALNAQ 298
PRK09243 PRK09243
nicotinate phosphoribosyltransferase; Validated
 15-498 3.77e-129

nicotinate phosphoribosyltransferase; Validated


Pssm-ID: 236426 [Multi-domain]  Cd Length: 464  Bit Score: 383.74  E-value: 3.77e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338  15 PLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASvlPPDTDPAFFE 94
Cdd:PRK09243   10 ALLTDLYELTMAQAYLRDGIHNRRAVFELFFRKLPFGRGYAVFAGLERLLEYLENLRFTEEDIEYLRS--LGIFDEDFLD 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338  95 HLRALDCSEvTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGpEKRLLEMGLRRAQ 174
Cdd:PRK09243   88 YLRNFRFTG-DVRAVPEGELVFPNEPLLRVEGPLAEAQLLETLLLNIINFQTLIATKAARIVSAAG-GRPLLEFGSRRAQ 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSfsgsevppdpmlapaagegpgvdlaakaqvwleqvc 254
Cdd:PRK09243  166 GPDAAVWAARAAYIGGFDATSNVLAGKRYGIPVSGTMAHSFVQA------------------------------------ 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 255 ahlglgvqepHPGERAAFVAYALAFPRAFQGLLDTYSVWRSGLPNFLAVALALGElGYRAVGVRLDSGDLLQQAQEIRKV 334
Cdd:PRK09243  210 ----------FDDEYEAFRAYAETYPDNTVLLVDTYDTLKSGVPNAIKVAKELGD-GIELGGVRIDSGDLAYLSKKVRKM 278

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 335 FRAAAaqfqvpwLESVLIVVSNNIDEEALARLAQE---------------------------LVAVGG----QPRMKLTE 383
Cdd:PRK09243  279 LDEAG-------FTDTKIVASNDLDEYTIASLKLQgapidgfgvgtklvtgsdapalggvykLVAIEGeggmIPKIKLSN 351

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 384 DPEKQTLPGSKAAFRLLGSDGSPLMDMLQLAEEPVpqaGQELRVW-PPGAQEPCTVRPAQVEPLLRLCLQQGQLCEPLPS 462
Cdd:PRK09243  352 SPEKVTTPGRKQVYRIYDKGGKAEADVITLADEEE---EEPLKMFhPVHTYKSKTVKNFDAEPLLVPVMENGKRVYELPS 428

                         490       500       510
                  ....*....|....*....|....*....|....*.
gi 1387845338 463 LAESRALAQLSLSRLSPEHRRLRSPAQYQVVLSERL 498
Cdd:PRK09243  429 LEEIRAYAAAQLASLPEEYKRLLNPHAYPVDLSQAL 464
PncB COG1488
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ...
 16-505 1.24e-120

Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis


Pssm-ID: 441097 [Multi-domain]  Cd Length: 445  Bit Score: 361.39  E-value: 1.24e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338  16 LLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVlpPDTDPAFFEH 95
Cdd:COG1488     6 LLTDLYKLTMAQAYLPEGTANRRAVFELFFRRLPFGRGYVVFAGLQRFLKYLENLRFTEEDIAYLRSL--GVFDEDFLDY 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338  96 LRALDCSeVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGpEKRLLEMGLRRAQG 175
Cdd:COG1488    84 LADFRFP-GDIRAVPEGTVVFPGEPLLTVEGTLPEAQLLETLLLNILNYPTLIATKAARIVQAAG-GRPLHDFGLRRAHG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 176 PDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSfsgsevppdpmlapaagegpgvdlaakaqvwleqvca 255
Cdd:COG1488   162 LEAAVAAARAAYLAGFAGTSNVLAGRYYGIPSVGTMAHSFVQA------------------------------------- 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 256 hlglgvqepHPGERAAFVAYALAFPRAFQGLLDTYSVWrSGLPNflAVALAlGELG--YRAVGVRLDSGDLLQQAQEIRK 333
Cdd:COG1488   205 ---------HDDELEAFRAFAEAYPDGTTLLVDTYDTL-SGVPN--AIELA-KELLarGGLLGIRLDSGDLAYLSKQARE 271

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 334 VFRAAAaqfqvpwLESVLIVVSNNIDEEALARLAQE---------------------------LVAVGG----QPRMKLT 382
Cdd:COG1488   272 LLDEAG-------LPDVRIIASDDLDEYRIAALLEQgapidvfgvgtrlvtssdrptlgfvykLVAVEGdgewRPVIKLS 344

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 383 EDPEKQTLPGSKAAFRlLGSDGSPLMDMLQLAEEPVPQAGqelrvwppgaqepctvrpaqvEPLLRLCLQQGQLCEPLPS 462
Cdd:COG1488   345 ETPGKKSKPGRKQVYR-RDEDGKATADLVALEDEPLPGEP---------------------EPLLVPVFRDGKLVYELPS 402

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|...
gi 1387845338 463 LAESRALAQLSLSRLSPEHRRLRSPAQYQVVLSERLQALVNSL 505
Cdd:COG1488   403 LEEIRERAAAQLAELPEELKRLRNPPAYPVDLSEALWDLKEQL 445
PRK12484 PRK12484
nicotinate phosphoribosyltransferase; Provisional
 16-507 1.09e-89

nicotinate phosphoribosyltransferase; Provisional


Pssm-ID: 237112 [Multi-domain]  Cd Length: 443  Bit Score: 281.63  E-value: 1.09e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338  16 LLTDLYQATMALGYWRAGrARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLP-PDTDPAFFE 94
Cdd:PRK12484    6 LLTDLYEVTMANAYLREG-MSAPATFSLFYRKLPDGRGFLIAAGLADVVEFLEAFRFDEQDLRYLRGLNQfSEEFLAWLA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338  95 HLRaLDCSevtVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLiAGPEKRLLEMGLRRAQ 174
Cdd:PRK12484   85 GLR-FTGD---VRAVPEGTVVFPNEPLLEVTAPLIEAQLVETFLLNQINHQSLIASKAARCVL-AAAGRPVVDFGARRAH 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFsgsevppdpmlapaagegpgvdlaakaqvwleqvc 254
Cdd:PRK12484  160 GTDAACYVARASYLAGAAGTSNVLAARQYGIPASGTMAHSFVEAF----------------------------------- 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 255 ahlglgvqephPGERAAFVAYALAFPRAFQGLLDTYSVWRsGLPNFLAVALALGElGYRAVGVRLDSGDLLQQAQEIRKV 334
Cdd:PRK12484  205 -----------PDEVAAFRAFARLYPDATTLLVDTYDTLR-GVRNAIEVAKELGN-RFDPRGVRLDSGDLAELSKATRAI 271

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 335 FRAAAaqfqvpwLESVLIVVSNNIDEEALARL---------------------------AQELVAVGGQPRMKLTedPEK 387
Cdd:PRK12484  272 LDAAG-------LEQVKIVASGGLDEYRIAALlaagapidgfgvgtrlgvaadapvldsAYKLVAYEGRGVTKLS--SGK 342

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 388 QTLPGSKAAFRLLGSdGSPLMDMLQLAEEPVpqagqelrvwPPGAqepctvrpaqvEPLLRLCLQQGQLCEPLPSLAESR 467
Cdd:PRK12484  343 VTYPGRKQVFRLYEH-GTACGDVIGLHTENI----------PDGR-----------EPLLVPVMTNGRRIQHAPTLDGAR 400

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|
gi 1387845338 468 ALAQLSLSRLSPEHRRLRSPAQYQVVLSERLQALVNSLCA 507
Cdd:PRK12484  401 DWCEAQLAALPPEARRLVDPVAVSVTLSGELARLRHADTA 440
NAPRTase_PncB cd01567
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase ...
 15-373 1.54e-89

Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.


Pssm-ID: 238801 [Multi-domain]  Cd Length: 343  Bit Score: 278.00  E-value: 1.54e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338  15 PLLTDLYQATMALGYWrAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPpdtDPAFFE 94
Cdd:cd01567     1 LLDTDLYKLTMMQAYL-YPYPNTRVVFEFTFRSNPFGGDYIVFAGLEEVLKLLENLRFTEEEIEYLKKLLI---FGEFFL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338  95 HLRALDCSEVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAG-----------PEK 163
Cdd:cd01567    77 YLLFLGKLPLEIYALPEGTVVFPKEPLLTIEGPWPEAGLLETPLLAIWNEATSIATKAARKKLAAGglletkdnleeLGF 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 164 RLLEMGLRRAQGPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFSGSEVppdpmlapaagegpgvdla 243
Cdd:cd01567   157 KLHDFGTRRRHSPEAALSGGRAALIGGFGGTSNVAAAKKLGIPPIGTMAHSWIQAFGALEE------------------- 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 244 akaqvwleqvcahlglgvqephpgerAAFVAYALAFPRAFQGLL----DTYSVWRsGLPNFLAVALALGElGYRAVGVRL 319
Cdd:cd01567   218 --------------------------AAFEAFARWLPQFGGGLGialiDTYDTDN-GFLNALKLAKALGA-GGGLLGVRL 269

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1387845338 320 DSGDLLQQAQEIRKVFRAAAAqfqvpWLESVLIVVSNNID-EEALARLAQELVAV 373
Cdd:cd01567   270 DSGDPVELIKKVRKHLDELGI-----DLNKKKIIISGDLDtEEAIELLLEQGASP 319
PRTase_typeII cd00516
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an ...
 19-373 4.84e-50

Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate phosphoribosyltransferase (NAPRTase), to be used in the synthesis of NAD. QAPRTase catalyses the reaction of quinolinic acid (QA) with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to produce nicotinic acid mononucleotide (NAMN), pyrophosphate and carbon dioxide, an important step in the de novo synthesis of NAD. NAPRTase catalyses a similar reaction leading to NAMN and pyrophosphate, using nicotinic acid an PPRP as substrates, used in the NAD salvage pathway.


Pssm-ID: 238286 [Multi-domain]  Cd Length: 281  Bit Score: 172.81  E-value: 4.84e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338  19 DLYQATMALGYwraGRARDAAEFELFFRRCPFGgafaLAAGLRDCVRFLRAFRLRDAdvqflasvlppdtdpaffehlra 98
Cdd:cd00516     1 DLYKLTMIQAY---PPPDTRATAEFTAREDPYG----VLAGLEEALELLELLRFPGP----------------------- 50

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338  99 ldcseVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIA-GPEKRLLEMGLRRAQgPD 177
Cdd:cd00516    51 -----LVILAVPEGTVVEPGEPLLTIEGPARELLLLERVLLNLLQRLSGIATATARYVEAAkGANTKVHDFGTRKTT-PG 124

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 178 GGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFsgsevppdpmlapaagegpgvdlaakaqvwleqvcahl 257
Cdd:cd00516   125 LRLLEKYAVLIGGGDGHRNGLSDAILIKDNHGTMAHSIIQAF-------------------------------------- 166

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 258 glgvqephpGERAAFVAYALAFPRAFQGLLDTYSVWrsgLPNFLAVALALgelgyRAVGVRLDSGDL--LQQAQEIRKVF 335
Cdd:cd00516   167 ---------GELAAVKALRRWLPELFIALIDVEVDT---LEEALEAAKAG-----GADGIRLDSGSPeeLDPAVLILKAR 229

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1387845338 336 RAaaaqFQVPWLESVLIVVSNNIDEEALARLAQELVAV 373
Cdd:cd00516   230 AH----LDGKGLPRVKIEASGGLDEENIRAYAETGVDV 263
NAPRTase_N pfam17767
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate ...
 16-143 1.19e-45

Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This is the N-terminal domain of the enzyme.


Pssm-ID: 465494 [Multi-domain]  Cd Length: 125  Bit Score: 155.75  E-value: 1.19e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338  16 LLTDLYQATMALGYWRAGRARDAaEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPdTDPAFFEH 95
Cdd:pfam17767   1 LDTDLYKLTMAQAYFKNGPDVQV-VFEFFNRTNPFGGLYAVFAGLEEQIEFLENLRFTEEEIEYLRRSLPY-FKPDFLDY 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1387845338  96 LRALDCSEVTVrALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVS 143
Cdd:pfam17767  79 LRNFRFDPSIV-AVPEGEVVFPGEPLLRIEGPWLETILLETPLLAIVN 125
NAPRTase_C pfam17956
Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus ...
 394-501 2.46e-31

Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus of some Nicotinate phosphoribosyltransferase enzymes. The function of this domain is uncertain.


Pssm-ID: 465585 [Multi-domain]  Cd Length: 111  Bit Score: 116.90  E-value: 2.46e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 394 KAAFRLLGSDGSPLMDMLQLAEEPVPQAGQELRVWPPGA-QEPCTVRPAQVEPLLRLCLQQGQLCEPLPSLAESRALAQL 472
Cdd:pfam17956   2 KQVYRLYDKDGKAIADLITLADEPPPDPGEEILCFHPFDeWKRKTVTPFTVEPLLKPVFEDGKLVYELPTLEEIRAYVQE 81

                          90       100
                  ....*....|....*....|....*....
gi 1387845338 473 SLSRLSPEHRRLRSPAQYQVVLSERLQAL 501
Cdd:pfam17956  82 QLSRLWPEHKRLLNPHPYKVDLSEKLYQL 110
NAPRTase_B cd01571
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate ...
 94-371 5.77e-24

Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.


Pssm-ID: 238805 [Multi-domain]  Cd Length: 302  Bit Score: 101.97  E-value: 5.77e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338  94 EHLRALDCSEVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGpEKRLLEMGLRR- 172
Cdd:cd01571    43 EVLALLEGLPVKVYALPEGTIFNPKEPVLRIEGPYQDFGELETAILGILARASSIATNAARVKLAAG-DKPVISFGDRRd 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 173 --AQGPDGGLTAstysYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFSGSEVppdpmlapaagegpgvdlaakaqvwl 250
Cdd:cd01571   122 hpAIQPMDGRAA----YIGGCDGVSTVLGAELLGEKPSGTMPHALIQIFGGDQV-------------------------- 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 251 eqvcahlglgvqephpgerAAFVAYALAFPRAFQ--GLLDTYSVWRsglpnfLAVALALGELGYRAVGVRLDS-----GD 323
Cdd:cd01571   172 -------------------EAWKAFDETYPEDVPriALIDTFNDEK------EEALKAAKALGDKLDGVRLDTpssrrGV 226

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1387845338 324 LLQQAQEIRKVFRAAAAQfqvpwleSVLIVVSNNIDEEALARLAQELV 371
Cdd:cd01571   227 FRYLIREVRWALDIRGYK-------HVKIFVSGGLDEEDIKELEDVGV 267
PRK08662 PRK08662
nicotinate phosphoribosyltransferase; Reviewed
 103-367 1.46e-17

nicotinate phosphoribosyltransferase; Reviewed


Pssm-ID: 236328 [Multi-domain]  Cd Length: 343  Bit Score: 83.77  E-value: 1.46e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 103 EVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGpEKRLLEMGLRR---AQGPdgg 179
Cdd:PRK08662   69 PVDVYALPEGTLFDPKEPVMRIEGPYLEFGIYETALLGILAHASGIATAAARCKEAAG-DKPVLSFGARHvhpAIAP--- 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 180 lTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFsGSEVppdpmlapaagegpgvdLAAKAqvWLEQVcahlgl 259
Cdd:PRK08662  145 -MMDRAAYIGGCDGVSGVLGAELLGIEPSGTMPHALILIF-GDQV-----------------EAWKA--FDEVV------ 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 260 gvqephPGEraafvayalaFPRAFqgLLDTYSVWRSglpNFLAVALALGElgyRAVGVRLDS-----GDLLQQAQEIRKV 334
Cdd:PRK08662  198 ------PPD----------VPRIA--LVDTFKDERE---EALRAAEALGD---RLDGVRLDTpssrrGNFRKIVREVRWT 253

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1387845338 335 FRAAAaqfqvpwLESVLIVVSNNIDEEALARLA 367
Cdd:PRK08662  254 LDIRG-------YEHVKIFVSGGLDPERIRELR 279
PRK05321 PRK05321
nicotinate phosphoribosyltransferase; Provisional
 14-213 5.11e-08

nicotinate phosphoribosyltransferase; Provisional


Pssm-ID: 235406 [Multi-domain]  Cd Length: 400  Bit Score: 55.15  E-value: 5.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338  14 RPLL-TDLYQATMALGYWRagRARDA-AEFELffrRCPFGGAFA--LAAGLRDCVRFLRAFRLRDADVQFLAS--VLPPD 87
Cdd:PRK05321   10 RSLLdTDFYKLTMQQAVLH--HYPDAqVEYEF---ICRNDEVDLaeYIDEIREQLDHLCTLRLTDDELDYLRGlpFFKPD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338  88 tdpaFFEHLRA--LDCSEVTVRAlPEGSLAfpgvplLQVSGPLLVVQLLETPLLCLVS-----YASLVATNA---ARL-- 155
Cdd:PRK05321   85 ----FLDWLRLfrLNPYEVTVSI-DDGQLD------IRIEGPWLETILWEVPLLAIISelyfrARSPEVLYAqakRRLwe 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1387845338 156 ---RLIAGPEK---RLLEMGLRRaqgpdggltasTYSYL--------------GGFDSSSNVLAGQLRGVPVAGTLAH 213
Cdd:PRK05321  154 kieLLKALPDLsgfKIADFGTRR-----------RFSFEwqeevvealkeglpGAFVGTSNVHLAMKLGLTPIGTMAH 220
PncB_like cd01401
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate ...
 14-213 4.50e-07

Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria, archea and funghi.


Pssm-ID: 238695 [Multi-domain]  Cd Length: 377  Bit Score: 51.86  E-value: 4.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338  14 RPLL-TDLYQATMALGYWRA-GRARDAAEF-----ELFFRRcpfggafaLAAGLRDCVRFLRAFRLRDADVQFLASVLPP 86
Cdd:cd01401     1 RSLLdTDLYKLTMQQAVLHHyPDVQVTYEFtnrspEDFLEE--------AAEALREQIDHLANLRFSEEELAYLRRSLPF 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338  87 DTdPAFFEHLRA--LDCSEVTVRA-LPEGSLAfpgvplLQVSGPLLVVQLLETPLLCLVS--YASLVATNA--------- 152
Cdd:cd01401    73 LK-PDYLDYLELfrLNPEEVVVRLdTGKGQLD------IRISGPWKDTILYEVPLLAIVSevYFRFRDADWdyeeqlekl 145

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1387845338 153 --------ARLRLIAGPEKRLLEMGLRRAQGPD------GGLTASTYSYLGGfdsSSNVLAGQLRGVPVAGTLAH 213
Cdd:cd01401   146 eeklerllEEAKRRDLNGFRFSDFGTRRRFSYEvqetvlKGLKQAAPGYLTG---TSNVHFAMKYGLTPIGTVAH 217
PRK09198 PRK09198
putative nicotinate phosphoribosyltransferase; Provisional
 104-158 3.26e-04

putative nicotinate phosphoribosyltransferase; Provisional


Pssm-ID: 236407 [Multi-domain]  Cd Length: 463  Bit Score: 43.34  E-value: 3.26e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1387845338 104 VTVRALPEGSLAFPGVPLLQVSG--PLL--VVQLLETPLLCLVSYASLVATNAARLRLI 158
Cdd:PRK09198   98 LRIKAVPEGSVVPVHNVLMTIENtdPEFfwLPNYLETLLLRNVWYPSTVATISWEYKQL 156
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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