|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02885 |
PLN02885 |
nicotinate phosphoribosyltransferase |
15-498 |
0e+00 |
|
nicotinate phosphoribosyltransferase
Pssm-ID: 178473 [Multi-domain] Cd Length: 545 Bit Score: 559.27 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 15 PLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPDTDPAFFE 94
Cdd:PLN02885 12 PLLTDLYQFTMAYAYWKAGKHLDRAVFDLFFRKNPFGGEYTVFAGLEECLRFIANFKFTDDDIDFLRSVMPSGCEDAFFD 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 95 HLRALDCSEVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGPEKRLLEMGLRRAQ 174
Cdd:PLN02885 92 YLRGLDCSDVEVYAIPEGSVVFPRVPLMRIEGPLAVVQLLETTFLTLVNYASLVATNAARHRLVAGKSKVLLEFGLRRAQ 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFSGSEVPPDPMLAPAAGEGPGVDLAAKAQVWLE--Q 252
Cdd:PLN02885 172 GPDGGISASKYCYLGGFDATSNVEAGRLFGIPVRGTHSHAFVSSYMGLDEIVDKTLRSADGSSVCEDFVSLVQEWLSklQ 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 253 VCAHLGLGVQEPHPGERAAFVAYALAFPRAFQGLLDTYSVWRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQQAQEIR 332
Cdd:PLN02885 252 ESSSLRGVFSETNQSELAAFTSYALAFPNSFLALVDTYDVMKSGIPNFCAVALALNDLGYKAVGIRLDSGDLAYLSLEAR 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 333 KVFRAAAAQFQVPWLESVLIVVSNNIDEEALARLAQE---------------------------LVAVGGQPRMKLTEDP 385
Cdd:PLN02885 332 KFFRTIEEELGVPGFGKMSITASNDINEETLDALNKQgheidafgigthlvtcyaqpalgcvykLVEINGQPRIKLSEDV 411
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 386 EKQTLPGSKAAFRLLGSDGSPLMDMLQLAEEPVPQAGQelRVW---PPGAQEPCTVRPAQVEPLLRlCLQQGQLCEP--- 459
Cdd:PLN02885 412 EKVTIPCKKRCYRLYGKEGYPLVDLMTGENEPPPKVGE--RILcrhPFNESKRAYVVPQRVEELLK-CYWDGSSGKPree 488
|
490 500 510
....*....|....*....|....*....|....*....
gi 1387845338 460 LPSLAESRALAQLSLSRLSPEHRRLRSPAQYQVVLSERL 498
Cdd:PLN02885 489 LPSLKEIRERCMKQLERMRPDHMRRLNPTPYKVSVSAKL 527
|
|
| NAPRTase_put |
TIGR01513 |
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of ... |
15-498 |
0e+00 |
|
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This model represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 273666 [Multi-domain] Cd Length: 443 Bit Score: 548.50 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 15 PLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVlpPDTDPAFFE 94
Cdd:TIGR01513 1 ALLTDLYELTMAQGYFREGKANQPAVFEVFFRKLPFGRGYAVFAGLEDLLEFLENFRFDAEDIEYLASL--GIFDDAFLD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 95 HLRALDCSeVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGPEKrLLEMGLRRAQ 174
Cdd:TIGR01513 79 YLREFRFS-GTVRALPEGSLVFPNEPLLQVEGPLIEAQLLETLVLNIINFQTLIATKAARIVLAAGGKP-LLEFGLRRAQ 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFsgsevppdpmlapaagegpgvdlaakaqvwleqvc 254
Cdd:TIGR01513 157 GPDAALKAARAAYIGGADGTSNVLAGRLYGIPVSGTMAHSFVMSF----------------------------------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 255 ahlglgvqephPGERAAFVAYALAFPRAFQGLLDTYSVWRSGLPNFLAVALALGELGYrAVGVRLDSGDLLQQAQEIRKV 334
Cdd:TIGR01513 202 -----------DNELAAFRAYAKLYPKATVLLVDTYDTLRSGLPNAIAVAKELGEQGK-VVGVRIDSGDLLYLSKQARKQ 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 335 FRAAAaqfqvpwLESVLIVVSNNIDEEALARLAQE---------------------------LVAVGGQPRMKLTEDPEK 387
Cdd:TIGR01513 270 LDAAG-------LTQVKIVVSNDLDENSIAALKAEgapidvygvgtslvtasdapalggvykLVAYEGRPVMKLSENPEK 342
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 388 QTLPGSKAAFRLLGSDGSPLMDMLQLAEEPVPQAgqelrvwppgAQEPCTVRPAQVEPLLRLCLQQGQLCEPLPSLAESR 467
Cdd:TIGR01513 343 STLPGRKQVFRLYDATGKFLGDELTLADEPIEDL----------NQEKCTPVFAPVEPLLRLVMKNGQRVRPLPSLAEIR 412
|
490 500 510
....*....|....*....|....*....|.
gi 1387845338 468 ALAQLSLSRLSPEHRRLRSPAQYQVVLSERL 498
Cdd:TIGR01513 413 ARAREQLSKLPPEYLRLLNPHVYPVSLSPRL 443
|
|
| NAPRTase_A |
cd01570 |
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ... |
15-369 |
4.14e-144 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).
Pssm-ID: 238804 [Multi-domain] Cd Length: 327 Bit Score: 416.59 E-value: 4.14e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 15 PLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPdtDPAFFE 94
Cdd:cd01570 1 ALLTDLYQLTMAQAYWKEGKHNKPAVFELFFRKLPFGGGYAVFAGLEELLEYLENFRFTEEDIDYLRSLGIF--DEEFLD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 95 HLRALDcSEVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGPeKRLLEMGLRRAQ 174
Cdd:cd01570 79 YLRGFR-FTGTIYAIPEGEVVFPNEPLLTVEGPLIEAQLLETLLLNLINFQTLIATKAARVRLAAGG-RPLLEFGLRRAQ 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFsgsevppdpmlapaagegpgvdlaakaqvwleqvc 254
Cdd:cd01570 157 GPDAALSAARAAYIGGFDGTSNVLAGKLYGIPVSGTMAHSFVQAF----------------------------------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 255 ahlglgvqephPGERAAFVAYALAFPRAFQGLLDTYSVWRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQQAQEIRKV 334
Cdd:cd01570 202 -----------DDELAAFRAFAEAYPDNFTLLVDTYDTLRSGLPNAIAVAKELGALGYRLVGVRIDSGDLAYLSKEARKM 270
|
330 340 350
....*....|....*....|....*....|....*
gi 1387845338 335 FRAAAaqfqvpwLESVLIVVSNNIDEEALARLAQE 369
Cdd:cd01570 271 LDEAG-------LTKVKIVASNDLDEYTIAALNAQ 298
|
|
| PncB |
COG1488 |
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ... |
16-505 |
1.24e-120 |
|
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis
Pssm-ID: 441097 [Multi-domain] Cd Length: 445 Bit Score: 361.39 E-value: 1.24e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 16 LLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVlpPDTDPAFFEH 95
Cdd:COG1488 6 LLTDLYKLTMAQAYLPEGTANRRAVFELFFRRLPFGRGYVVFAGLQRFLKYLENLRFTEEDIAYLRSL--GVFDEDFLDY 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 96 LRALDCSeVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGpEKRLLEMGLRRAQG 175
Cdd:COG1488 84 LADFRFP-GDIRAVPEGTVVFPGEPLLTVEGTLPEAQLLETLLLNILNYPTLIATKAARIVQAAG-GRPLHDFGLRRAHG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 176 PDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSfsgsevppdpmlapaagegpgvdlaakaqvwleqvca 255
Cdd:COG1488 162 LEAAVAAARAAYLAGFAGTSNVLAGRYYGIPSVGTMAHSFVQA------------------------------------- 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 256 hlglgvqepHPGERAAFVAYALAFPRAFQGLLDTYSVWrSGLPNflAVALAlGELG--YRAVGVRLDSGDLLQQAQEIRK 333
Cdd:COG1488 205 ---------HDDELEAFRAFAEAYPDGTTLLVDTYDTL-SGVPN--AIELA-KELLarGGLLGIRLDSGDLAYLSKQARE 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 334 VFRAAAaqfqvpwLESVLIVVSNNIDEEALARLAQE---------------------------LVAVGG----QPRMKLT 382
Cdd:COG1488 272 LLDEAG-------LPDVRIIASDDLDEYRIAALLEQgapidvfgvgtrlvtssdrptlgfvykLVAVEGdgewRPVIKLS 344
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 383 EDPEKQTLPGSKAAFRlLGSDGSPLMDMLQLAEEPVPQAGqelrvwppgaqepctvrpaqvEPLLRLCLQQGQLCEPLPS 462
Cdd:COG1488 345 ETPGKKSKPGRKQVYR-RDEDGKATADLVALEDEPLPGEP---------------------EPLLVPVFRDGKLVYELPS 402
|
490 500 510 520
....*....|....*....|....*....|....*....|...
gi 1387845338 463 LAESRALAQLSLSRLSPEHRRLRSPAQYQVVLSERLQALVNSL 505
Cdd:COG1488 403 LEEIRERAAAQLAELPEELKRLRNPPAYPVDLSEALWDLKEQL 445
|
|
| NAPRTase_N |
pfam17767 |
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate ... |
16-143 |
1.19e-45 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This is the N-terminal domain of the enzyme.
Pssm-ID: 465494 [Multi-domain] Cd Length: 125 Bit Score: 155.75 E-value: 1.19e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 16 LLTDLYQATMALGYWRAGRARDAaEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPdTDPAFFEH 95
Cdd:pfam17767 1 LDTDLYKLTMAQAYFKNGPDVQV-VFEFFNRTNPFGGLYAVFAGLEEQIEFLENLRFTEEEIEYLRRSLPY-FKPDFLDY 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1387845338 96 LRALDCSEVTVrALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVS 143
Cdd:pfam17767 79 LRNFRFDPSIV-AVPEGEVVFPGEPLLRIEGPWLETILLETPLLAIVN 125
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02885 |
PLN02885 |
nicotinate phosphoribosyltransferase |
15-498 |
0e+00 |
|
nicotinate phosphoribosyltransferase
Pssm-ID: 178473 [Multi-domain] Cd Length: 545 Bit Score: 559.27 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 15 PLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPDTDPAFFE 94
Cdd:PLN02885 12 PLLTDLYQFTMAYAYWKAGKHLDRAVFDLFFRKNPFGGEYTVFAGLEECLRFIANFKFTDDDIDFLRSVMPSGCEDAFFD 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 95 HLRALDCSEVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGPEKRLLEMGLRRAQ 174
Cdd:PLN02885 92 YLRGLDCSDVEVYAIPEGSVVFPRVPLMRIEGPLAVVQLLETTFLTLVNYASLVATNAARHRLVAGKSKVLLEFGLRRAQ 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFSGSEVPPDPMLAPAAGEGPGVDLAAKAQVWLE--Q 252
Cdd:PLN02885 172 GPDGGISASKYCYLGGFDATSNVEAGRLFGIPVRGTHSHAFVSSYMGLDEIVDKTLRSADGSSVCEDFVSLVQEWLSklQ 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 253 VCAHLGLGVQEPHPGERAAFVAYALAFPRAFQGLLDTYSVWRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQQAQEIR 332
Cdd:PLN02885 252 ESSSLRGVFSETNQSELAAFTSYALAFPNSFLALVDTYDVMKSGIPNFCAVALALNDLGYKAVGIRLDSGDLAYLSLEAR 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 333 KVFRAAAAQFQVPWLESVLIVVSNNIDEEALARLAQE---------------------------LVAVGGQPRMKLTEDP 385
Cdd:PLN02885 332 KFFRTIEEELGVPGFGKMSITASNDINEETLDALNKQgheidafgigthlvtcyaqpalgcvykLVEINGQPRIKLSEDV 411
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 386 EKQTLPGSKAAFRLLGSDGSPLMDMLQLAEEPVPQAGQelRVW---PPGAQEPCTVRPAQVEPLLRlCLQQGQLCEP--- 459
Cdd:PLN02885 412 EKVTIPCKKRCYRLYGKEGYPLVDLMTGENEPPPKVGE--RILcrhPFNESKRAYVVPQRVEELLK-CYWDGSSGKPree 488
|
490 500 510
....*....|....*....|....*....|....*....
gi 1387845338 460 LPSLAESRALAQLSLSRLSPEHRRLRSPAQYQVVLSERL 498
Cdd:PLN02885 489 LPSLKEIRERCMKQLERMRPDHMRRLNPTPYKVSVSAKL 527
|
|
| NAPRTase_put |
TIGR01513 |
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of ... |
15-498 |
0e+00 |
|
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This model represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 273666 [Multi-domain] Cd Length: 443 Bit Score: 548.50 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 15 PLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVlpPDTDPAFFE 94
Cdd:TIGR01513 1 ALLTDLYELTMAQGYFREGKANQPAVFEVFFRKLPFGRGYAVFAGLEDLLEFLENFRFDAEDIEYLASL--GIFDDAFLD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 95 HLRALDCSeVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGPEKrLLEMGLRRAQ 174
Cdd:TIGR01513 79 YLREFRFS-GTVRALPEGSLVFPNEPLLQVEGPLIEAQLLETLVLNIINFQTLIATKAARIVLAAGGKP-LLEFGLRRAQ 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFsgsevppdpmlapaagegpgvdlaakaqvwleqvc 254
Cdd:TIGR01513 157 GPDAALKAARAAYIGGADGTSNVLAGRLYGIPVSGTMAHSFVMSF----------------------------------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 255 ahlglgvqephPGERAAFVAYALAFPRAFQGLLDTYSVWRSGLPNFLAVALALGELGYrAVGVRLDSGDLLQQAQEIRKV 334
Cdd:TIGR01513 202 -----------DNELAAFRAYAKLYPKATVLLVDTYDTLRSGLPNAIAVAKELGEQGK-VVGVRIDSGDLLYLSKQARKQ 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 335 FRAAAaqfqvpwLESVLIVVSNNIDEEALARLAQE---------------------------LVAVGGQPRMKLTEDPEK 387
Cdd:TIGR01513 270 LDAAG-------LTQVKIVVSNDLDENSIAALKAEgapidvygvgtslvtasdapalggvykLVAYEGRPVMKLSENPEK 342
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 388 QTLPGSKAAFRLLGSDGSPLMDMLQLAEEPVPQAgqelrvwppgAQEPCTVRPAQVEPLLRLCLQQGQLCEPLPSLAESR 467
Cdd:TIGR01513 343 STLPGRKQVFRLYDATGKFLGDELTLADEPIEDL----------NQEKCTPVFAPVEPLLRLVMKNGQRVRPLPSLAEIR 412
|
490 500 510
....*....|....*....|....*....|.
gi 1387845338 468 ALAQLSLSRLSPEHRRLRSPAQYQVVLSERL 498
Cdd:TIGR01513 413 ARAREQLSKLPPEYLRLLNPHVYPVSLSPRL 443
|
|
| NAPRTase_A |
cd01570 |
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ... |
15-369 |
4.14e-144 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).
Pssm-ID: 238804 [Multi-domain] Cd Length: 327 Bit Score: 416.59 E-value: 4.14e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 15 PLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPdtDPAFFE 94
Cdd:cd01570 1 ALLTDLYQLTMAQAYWKEGKHNKPAVFELFFRKLPFGGGYAVFAGLEELLEYLENFRFTEEDIDYLRSLGIF--DEEFLD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 95 HLRALDcSEVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGPeKRLLEMGLRRAQ 174
Cdd:cd01570 79 YLRGFR-FTGTIYAIPEGEVVFPNEPLLTVEGPLIEAQLLETLLLNLINFQTLIATKAARVRLAAGG-RPLLEFGLRRAQ 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFsgsevppdpmlapaagegpgvdlaakaqvwleqvc 254
Cdd:cd01570 157 GPDAALSAARAAYIGGFDGTSNVLAGKLYGIPVSGTMAHSFVQAF----------------------------------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 255 ahlglgvqephPGERAAFVAYALAFPRAFQGLLDTYSVWRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQQAQEIRKV 334
Cdd:cd01570 202 -----------DDELAAFRAFAEAYPDNFTLLVDTYDTLRSGLPNAIAVAKELGALGYRLVGVRIDSGDLAYLSKEARKM 270
|
330 340 350
....*....|....*....|....*....|....*
gi 1387845338 335 FRAAAaqfqvpwLESVLIVVSNNIDEEALARLAQE 369
Cdd:cd01570 271 LDEAG-------LTKVKIVASNDLDEYTIAALNAQ 298
|
|
| PRK09243 |
PRK09243 |
nicotinate phosphoribosyltransferase; Validated |
15-498 |
3.77e-129 |
|
nicotinate phosphoribosyltransferase; Validated
Pssm-ID: 236426 [Multi-domain] Cd Length: 464 Bit Score: 383.74 E-value: 3.77e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 15 PLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASvlPPDTDPAFFE 94
Cdd:PRK09243 10 ALLTDLYELTMAQAYLRDGIHNRRAVFELFFRKLPFGRGYAVFAGLERLLEYLENLRFTEEDIEYLRS--LGIFDEDFLD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 95 HLRALDCSEvTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGpEKRLLEMGLRRAQ 174
Cdd:PRK09243 88 YLRNFRFTG-DVRAVPEGELVFPNEPLLRVEGPLAEAQLLETLLLNIINFQTLIATKAARIVSAAG-GRPLLEFGSRRAQ 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSfsgsevppdpmlapaagegpgvdlaakaqvwleqvc 254
Cdd:PRK09243 166 GPDAAVWAARAAYIGGFDATSNVLAGKRYGIPVSGTMAHSFVQA------------------------------------ 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 255 ahlglgvqepHPGERAAFVAYALAFPRAFQGLLDTYSVWRSGLPNFLAVALALGElGYRAVGVRLDSGDLLQQAQEIRKV 334
Cdd:PRK09243 210 ----------FDDEYEAFRAYAETYPDNTVLLVDTYDTLKSGVPNAIKVAKELGD-GIELGGVRIDSGDLAYLSKKVRKM 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 335 FRAAAaqfqvpwLESVLIVVSNNIDEEALARLAQE---------------------------LVAVGG----QPRMKLTE 383
Cdd:PRK09243 279 LDEAG-------FTDTKIVASNDLDEYTIASLKLQgapidgfgvgtklvtgsdapalggvykLVAIEGeggmIPKIKLSN 351
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 384 DPEKQTLPGSKAAFRLLGSDGSPLMDMLQLAEEPVpqaGQELRVW-PPGAQEPCTVRPAQVEPLLRLCLQQGQLCEPLPS 462
Cdd:PRK09243 352 SPEKVTTPGRKQVYRIYDKGGKAEADVITLADEEE---EEPLKMFhPVHTYKSKTVKNFDAEPLLVPVMENGKRVYELPS 428
|
490 500 510
....*....|....*....|....*....|....*.
gi 1387845338 463 LAESRALAQLSLSRLSPEHRRLRSPAQYQVVLSERL 498
Cdd:PRK09243 429 LEEIRAYAAAQLASLPEEYKRLLNPHAYPVDLSQAL 464
|
|
| PncB |
COG1488 |
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ... |
16-505 |
1.24e-120 |
|
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis
Pssm-ID: 441097 [Multi-domain] Cd Length: 445 Bit Score: 361.39 E-value: 1.24e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 16 LLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVlpPDTDPAFFEH 95
Cdd:COG1488 6 LLTDLYKLTMAQAYLPEGTANRRAVFELFFRRLPFGRGYVVFAGLQRFLKYLENLRFTEEDIAYLRSL--GVFDEDFLDY 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 96 LRALDCSeVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGpEKRLLEMGLRRAQG 175
Cdd:COG1488 84 LADFRFP-GDIRAVPEGTVVFPGEPLLTVEGTLPEAQLLETLLLNILNYPTLIATKAARIVQAAG-GRPLHDFGLRRAHG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 176 PDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSfsgsevppdpmlapaagegpgvdlaakaqvwleqvca 255
Cdd:COG1488 162 LEAAVAAARAAYLAGFAGTSNVLAGRYYGIPSVGTMAHSFVQA------------------------------------- 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 256 hlglgvqepHPGERAAFVAYALAFPRAFQGLLDTYSVWrSGLPNflAVALAlGELG--YRAVGVRLDSGDLLQQAQEIRK 333
Cdd:COG1488 205 ---------HDDELEAFRAFAEAYPDGTTLLVDTYDTL-SGVPN--AIELA-KELLarGGLLGIRLDSGDLAYLSKQARE 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 334 VFRAAAaqfqvpwLESVLIVVSNNIDEEALARLAQE---------------------------LVAVGG----QPRMKLT 382
Cdd:COG1488 272 LLDEAG-------LPDVRIIASDDLDEYRIAALLEQgapidvfgvgtrlvtssdrptlgfvykLVAVEGdgewRPVIKLS 344
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 383 EDPEKQTLPGSKAAFRlLGSDGSPLMDMLQLAEEPVPQAGqelrvwppgaqepctvrpaqvEPLLRLCLQQGQLCEPLPS 462
Cdd:COG1488 345 ETPGKKSKPGRKQVYR-RDEDGKATADLVALEDEPLPGEP---------------------EPLLVPVFRDGKLVYELPS 402
|
490 500 510 520
....*....|....*....|....*....|....*....|...
gi 1387845338 463 LAESRALAQLSLSRLSPEHRRLRSPAQYQVVLSERLQALVNSL 505
Cdd:COG1488 403 LEEIRERAAAQLAELPEELKRLRNPPAYPVDLSEALWDLKEQL 445
|
|
| PRK12484 |
PRK12484 |
nicotinate phosphoribosyltransferase; Provisional |
16-507 |
1.09e-89 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 237112 [Multi-domain] Cd Length: 443 Bit Score: 281.63 E-value: 1.09e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 16 LLTDLYQATMALGYWRAGrARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLP-PDTDPAFFE 94
Cdd:PRK12484 6 LLTDLYEVTMANAYLREG-MSAPATFSLFYRKLPDGRGFLIAAGLADVVEFLEAFRFDEQDLRYLRGLNQfSEEFLAWLA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 95 HLRaLDCSevtVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLiAGPEKRLLEMGLRRAQ 174
Cdd:PRK12484 85 GLR-FTGD---VRAVPEGTVVFPNEPLLEVTAPLIEAQLVETFLLNQINHQSLIASKAARCVL-AAAGRPVVDFGARRAH 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFsgsevppdpmlapaagegpgvdlaakaqvwleqvc 254
Cdd:PRK12484 160 GTDAACYVARASYLAGAAGTSNVLAARQYGIPASGTMAHSFVEAF----------------------------------- 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 255 ahlglgvqephPGERAAFVAYALAFPRAFQGLLDTYSVWRsGLPNFLAVALALGElGYRAVGVRLDSGDLLQQAQEIRKV 334
Cdd:PRK12484 205 -----------PDEVAAFRAFARLYPDATTLLVDTYDTLR-GVRNAIEVAKELGN-RFDPRGVRLDSGDLAELSKATRAI 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 335 FRAAAaqfqvpwLESVLIVVSNNIDEEALARL---------------------------AQELVAVGGQPRMKLTedPEK 387
Cdd:PRK12484 272 LDAAG-------LEQVKIVASGGLDEYRIAALlaagapidgfgvgtrlgvaadapvldsAYKLVAYEGRGVTKLS--SGK 342
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 388 QTLPGSKAAFRLLGSdGSPLMDMLQLAEEPVpqagqelrvwPPGAqepctvrpaqvEPLLRLCLQQGQLCEPLPSLAESR 467
Cdd:PRK12484 343 VTYPGRKQVFRLYEH-GTACGDVIGLHTENI----------PDGR-----------EPLLVPVMTNGRRIQHAPTLDGAR 400
|
490 500 510 520
....*....|....*....|....*....|....*....|
gi 1387845338 468 ALAQLSLSRLSPEHRRLRSPAQYQVVLSERLQALVNSLCA 507
Cdd:PRK12484 401 DWCEAQLAALPPEARRLVDPVAVSVTLSGELARLRHADTA 440
|
|
| NAPRTase_PncB |
cd01567 |
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase ... |
15-373 |
1.54e-89 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.
Pssm-ID: 238801 [Multi-domain] Cd Length: 343 Bit Score: 278.00 E-value: 1.54e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 15 PLLTDLYQATMALGYWrAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPpdtDPAFFE 94
Cdd:cd01567 1 LLDTDLYKLTMMQAYL-YPYPNTRVVFEFTFRSNPFGGDYIVFAGLEEVLKLLENLRFTEEEIEYLKKLLI---FGEFFL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 95 HLRALDCSEVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAG-----------PEK 163
Cdd:cd01567 77 YLLFLGKLPLEIYALPEGTVVFPKEPLLTIEGPWPEAGLLETPLLAIWNEATSIATKAARKKLAAGglletkdnleeLGF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 164 RLLEMGLRRAQGPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFSGSEVppdpmlapaagegpgvdla 243
Cdd:cd01567 157 KLHDFGTRRRHSPEAALSGGRAALIGGFGGTSNVAAAKKLGIPPIGTMAHSWIQAFGALEE------------------- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 244 akaqvwleqvcahlglgvqephpgerAAFVAYALAFPRAFQGLL----DTYSVWRsGLPNFLAVALALGElGYRAVGVRL 319
Cdd:cd01567 218 --------------------------AAFEAFARWLPQFGGGLGialiDTYDTDN-GFLNALKLAKALGA-GGGLLGVRL 269
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1387845338 320 DSGDLLQQAQEIRKVFRAAAAqfqvpWLESVLIVVSNNID-EEALARLAQELVAV 373
Cdd:cd01567 270 DSGDPVELIKKVRKHLDELGI-----DLNKKKIIISGDLDtEEAIELLLEQGASP 319
|
|
| PRTase_typeII |
cd00516 |
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an ... |
19-373 |
4.84e-50 |
|
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate phosphoribosyltransferase (NAPRTase), to be used in the synthesis of NAD. QAPRTase catalyses the reaction of quinolinic acid (QA) with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to produce nicotinic acid mononucleotide (NAMN), pyrophosphate and carbon dioxide, an important step in the de novo synthesis of NAD. NAPRTase catalyses a similar reaction leading to NAMN and pyrophosphate, using nicotinic acid an PPRP as substrates, used in the NAD salvage pathway.
Pssm-ID: 238286 [Multi-domain] Cd Length: 281 Bit Score: 172.81 E-value: 4.84e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 19 DLYQATMALGYwraGRARDAAEFELFFRRCPFGgafaLAAGLRDCVRFLRAFRLRDAdvqflasvlppdtdpaffehlra 98
Cdd:cd00516 1 DLYKLTMIQAY---PPPDTRATAEFTAREDPYG----VLAGLEEALELLELLRFPGP----------------------- 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 99 ldcseVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIA-GPEKRLLEMGLRRAQgPD 177
Cdd:cd00516 51 -----LVILAVPEGTVVEPGEPLLTIEGPARELLLLERVLLNLLQRLSGIATATARYVEAAkGANTKVHDFGTRKTT-PG 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 178 GGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFsgsevppdpmlapaagegpgvdlaakaqvwleqvcahl 257
Cdd:cd00516 125 LRLLEKYAVLIGGGDGHRNGLSDAILIKDNHGTMAHSIIQAF-------------------------------------- 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 258 glgvqephpGERAAFVAYALAFPRAFQGLLDTYSVWrsgLPNFLAVALALgelgyRAVGVRLDSGDL--LQQAQEIRKVF 335
Cdd:cd00516 167 ---------GELAAVKALRRWLPELFIALIDVEVDT---LEEALEAAKAG-----GADGIRLDSGSPeeLDPAVLILKAR 229
|
330 340 350
....*....|....*....|....*....|....*...
gi 1387845338 336 RAaaaqFQVPWLESVLIVVSNNIDEEALARLAQELVAV 373
Cdd:cd00516 230 AH----LDGKGLPRVKIEASGGLDEENIRAYAETGVDV 263
|
|
| NAPRTase_N |
pfam17767 |
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate ... |
16-143 |
1.19e-45 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This is the N-terminal domain of the enzyme.
Pssm-ID: 465494 [Multi-domain] Cd Length: 125 Bit Score: 155.75 E-value: 1.19e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 16 LLTDLYQATMALGYWRAGRARDAaEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPdTDPAFFEH 95
Cdd:pfam17767 1 LDTDLYKLTMAQAYFKNGPDVQV-VFEFFNRTNPFGGLYAVFAGLEEQIEFLENLRFTEEEIEYLRRSLPY-FKPDFLDY 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1387845338 96 LRALDCSEVTVrALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVS 143
Cdd:pfam17767 79 LRNFRFDPSIV-AVPEGEVVFPGEPLLRIEGPWLETILLETPLLAIVN 125
|
|
| NAPRTase_C |
pfam17956 |
Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus ... |
394-501 |
2.46e-31 |
|
Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus of some Nicotinate phosphoribosyltransferase enzymes. The function of this domain is uncertain.
Pssm-ID: 465585 [Multi-domain] Cd Length: 111 Bit Score: 116.90 E-value: 2.46e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 394 KAAFRLLGSDGSPLMDMLQLAEEPVPQAGQELRVWPPGA-QEPCTVRPAQVEPLLRLCLQQGQLCEPLPSLAESRALAQL 472
Cdd:pfam17956 2 KQVYRLYDKDGKAIADLITLADEPPPDPGEEILCFHPFDeWKRKTVTPFTVEPLLKPVFEDGKLVYELPTLEEIRAYVQE 81
|
90 100
....*....|....*....|....*....
gi 1387845338 473 SLSRLSPEHRRLRSPAQYQVVLSERLQAL 501
Cdd:pfam17956 82 QLSRLWPEHKRLLNPHPYKVDLSEKLYQL 110
|
|
| NAPRTase_B |
cd01571 |
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate ... |
94-371 |
5.77e-24 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.
Pssm-ID: 238805 [Multi-domain] Cd Length: 302 Bit Score: 101.97 E-value: 5.77e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 94 EHLRALDCSEVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGpEKRLLEMGLRR- 172
Cdd:cd01571 43 EVLALLEGLPVKVYALPEGTIFNPKEPVLRIEGPYQDFGELETAILGILARASSIATNAARVKLAAG-DKPVISFGDRRd 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 173 --AQGPDGGLTAstysYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFSGSEVppdpmlapaagegpgvdlaakaqvwl 250
Cdd:cd01571 122 hpAIQPMDGRAA----YIGGCDGVSTVLGAELLGEKPSGTMPHALIQIFGGDQV-------------------------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 251 eqvcahlglgvqephpgerAAFVAYALAFPRAFQ--GLLDTYSVWRsglpnfLAVALALGELGYRAVGVRLDS-----GD 323
Cdd:cd01571 172 -------------------EAWKAFDETYPEDVPriALIDTFNDEK------EEALKAAKALGDKLDGVRLDTpssrrGV 226
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 1387845338 324 LLQQAQEIRKVFRAAAAQfqvpwleSVLIVVSNNIDEEALARLAQELV 371
Cdd:cd01571 227 FRYLIREVRWALDIRGYK-------HVKIFVSGGLDEEDIKELEDVGV 267
|
|
| PRK08662 |
PRK08662 |
nicotinate phosphoribosyltransferase; Reviewed |
103-367 |
1.46e-17 |
|
nicotinate phosphoribosyltransferase; Reviewed
Pssm-ID: 236328 [Multi-domain] Cd Length: 343 Bit Score: 83.77 E-value: 1.46e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 103 EVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGpEKRLLEMGLRR---AQGPdgg 179
Cdd:PRK08662 69 PVDVYALPEGTLFDPKEPVMRIEGPYLEFGIYETALLGILAHASGIATAAARCKEAAG-DKPVLSFGARHvhpAIAP--- 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 180 lTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFsGSEVppdpmlapaagegpgvdLAAKAqvWLEQVcahlgl 259
Cdd:PRK08662 145 -MMDRAAYIGGCDGVSGVLGAELLGIEPSGTMPHALILIF-GDQV-----------------EAWKA--FDEVV------ 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 260 gvqephPGEraafvayalaFPRAFqgLLDTYSVWRSglpNFLAVALALGElgyRAVGVRLDS-----GDLLQQAQEIRKV 334
Cdd:PRK08662 198 ------PPD----------VPRIA--LVDTFKDERE---EALRAAEALGD---RLDGVRLDTpssrrGNFRKIVREVRWT 253
|
250 260 270
....*....|....*....|....*....|...
gi 1387845338 335 FRAAAaqfqvpwLESVLIVVSNNIDEEALARLA 367
Cdd:PRK08662 254 LDIRG-------YEHVKIFVSGGLDPERIRELR 279
|
|
| PRK05321 |
PRK05321 |
nicotinate phosphoribosyltransferase; Provisional |
14-213 |
5.11e-08 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 235406 [Multi-domain] Cd Length: 400 Bit Score: 55.15 E-value: 5.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 14 RPLL-TDLYQATMALGYWRagRARDA-AEFELffrRCPFGGAFA--LAAGLRDCVRFLRAFRLRDADVQFLAS--VLPPD 87
Cdd:PRK05321 10 RSLLdTDFYKLTMQQAVLH--HYPDAqVEYEF---ICRNDEVDLaeYIDEIREQLDHLCTLRLTDDELDYLRGlpFFKPD 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 88 tdpaFFEHLRA--LDCSEVTVRAlPEGSLAfpgvplLQVSGPLLVVQLLETPLLCLVS-----YASLVATNA---ARL-- 155
Cdd:PRK05321 85 ----FLDWLRLfrLNPYEVTVSI-DDGQLD------IRIEGPWLETILWEVPLLAIISelyfrARSPEVLYAqakRRLwe 153
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1387845338 156 ---RLIAGPEK---RLLEMGLRRaqgpdggltasTYSYL--------------GGFDSSSNVLAGQLRGVPVAGTLAH 213
Cdd:PRK05321 154 kieLLKALPDLsgfKIADFGTRR-----------RFSFEwqeevvealkeglpGAFVGTSNVHLAMKLGLTPIGTMAH 220
|
|
| PncB_like |
cd01401 |
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate ... |
14-213 |
4.50e-07 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria, archea and funghi.
Pssm-ID: 238695 [Multi-domain] Cd Length: 377 Bit Score: 51.86 E-value: 4.50e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 14 RPLL-TDLYQATMALGYWRA-GRARDAAEF-----ELFFRRcpfggafaLAAGLRDCVRFLRAFRLRDADVQFLASVLPP 86
Cdd:cd01401 1 RSLLdTDLYKLTMQQAVLHHyPDVQVTYEFtnrspEDFLEE--------AAEALREQIDHLANLRFSEEELAYLRRSLPF 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845338 87 DTdPAFFEHLRA--LDCSEVTVRA-LPEGSLAfpgvplLQVSGPLLVVQLLETPLLCLVS--YASLVATNA--------- 152
Cdd:cd01401 73 LK-PDYLDYLELfrLNPEEVVVRLdTGKGQLD------IRISGPWKDTILYEVPLLAIVSevYFRFRDADWdyeeqlekl 145
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1387845338 153 --------ARLRLIAGPEKRLLEMGLRRAQGPD------GGLTASTYSYLGGfdsSSNVLAGQLRGVPVAGTLAH 213
Cdd:cd01401 146 eeklerllEEAKRRDLNGFRFSDFGTRRRFSYEvqetvlKGLKQAAPGYLTG---TSNVHFAMKYGLTPIGTVAH 217
|
|
| PRK09198 |
PRK09198 |
putative nicotinate phosphoribosyltransferase; Provisional |
104-158 |
3.26e-04 |
|
putative nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 236407 [Multi-domain] Cd Length: 463 Bit Score: 43.34 E-value: 3.26e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 1387845338 104 VTVRALPEGSLAFPGVPLLQVSG--PLL--VVQLLETPLLCLVSYASLVATNAARLRLI 158
Cdd:PRK09198 98 LRIKAVPEGSVVPVHNVLMTIENtdPEFfwLPNYLETLLLRNVWYPSTVATISWEYKQL 156
|
|
|