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Conserved domains on  [gi|1375456814|ref|NP_001349121|]
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zinc finger protein 668 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
65-419 1.15e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.58  E-value: 1.15e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375456814  65 KAEEASGDKVSASVAKPRPYACPLCPKAYKTAPELRSHGRSHTGEKPFPCPECGR--RFMQPVCLRVHLASHAGELPFRC 142
Cdd:COG5048    15 VLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLN 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375456814 143 TH-CPKAYGTLSKLKIHQRGHTGERPYACPDCGKSFADPSVFRKHRRTHAGLRPYSCERCGKAYAELK------------ 209
Cdd:COG5048    95 SKsLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpplpan 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375456814 210 ----------DLRNHERSHTGERPFLCSECGKSFSR-------------SSSLTCHQRIHA------------------- 247
Cdd:COG5048   175 slskdpssnlSLLISSNVSTSIPSSSENSPLSSSYSipssssdqnlensSSSLPLTTNSQLspksllsqspsslsssdss 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375456814 248 --AQKPYRCPACGKGFTQLSSYQSHERTHSG-EKPFLCPRCGRMFSDPSSFRRHQRAH----EGVKPYRC--EKCGKDFR 318
Cdd:COG5048   255 ssASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVnhsgESLKPFSCpySLCGKLFS 334

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375456814 319 QPADLAMHRRVHTGDRPFKC--LQCDKTFVASWDLKRHALVH-----SGQRPFRCE--ECGRAFAERASLTKHSRMHSGE 389
Cdd:COG5048   335 RNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSF 414

                         410       420       430
                  ....*....|....*....|....*....|..
gi 1375456814 390 RP--FHCNACGKSFVVLSSLRKHERTHRSNET 419
Cdd:COG5048   415 RPynCKNPPCSKSFNRHYNLIPHKKIHTNHAP 446
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
248-598 2.31e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.63  E-value: 2.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375456814 248 AQKPYRCPACGKGFTQLSSYQSHERTHSGEKPFLCPRCGR--MFSDPSSFRRHQRAHEGVKPYRCEKCGKDFRQPADLAM 325
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375456814 326 HRRVHTGDR----PFKCLQCDKTFVaSWDLKRHALVHSGQRPFRceECGRAFAERA----------------------SL 379
Cdd:COG5048   110 LSSSSSNSNdnnlLSSHSLPPSSRD-PQLPDLLSISNLRNNPLP--GNNSSSVNTPqsnslhpplpanslskdpssnlSL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375456814 380 TKHSRMHSGERPFHCNACGKSFVVLSSLRKHERTHRSNETTGAAPQQELVLGLALPVGVVGEGSaapvagagvgDAPAGL 459
Cdd:COG5048   187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSS----------SDSSSS 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375456814 460 LGLPPESG----GVVATQWQVVGMTVEhvecqdagvgEAPSTlgdagevggeetdekppQFVCRECKETFSTLTLLRRHE 535
Cdd:COG5048   257 ASESPRSSlptaSSQSSSPNESDSSSE----------KGFSL-----------------PIKSKQCNISFSRSSPLTRHL 309

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1375456814 536 RSH----PELRPFPCT--QCGKSFSDRAGLRKHSRTHSSVRPYSC--SQCPKAFLSASDLRKHERTHPVPI 598
Cdd:COG5048   310 RSVnhsgESLKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYKD 380
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
65-419 1.15e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.58  E-value: 1.15e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375456814  65 KAEEASGDKVSASVAKPRPYACPLCPKAYKTAPELRSHGRSHTGEKPFPCPECGR--RFMQPVCLRVHLASHAGELPFRC 142
Cdd:COG5048    15 VLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLN 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375456814 143 TH-CPKAYGTLSKLKIHQRGHTGERPYACPDCGKSFADPSVFRKHRRTHAGLRPYSCERCGKAYAELK------------ 209
Cdd:COG5048    95 SKsLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpplpan 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375456814 210 ----------DLRNHERSHTGERPFLCSECGKSFSR-------------SSSLTCHQRIHA------------------- 247
Cdd:COG5048   175 slskdpssnlSLLISSNVSTSIPSSSENSPLSSSYSipssssdqnlensSSSLPLTTNSQLspksllsqspsslsssdss 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375456814 248 --AQKPYRCPACGKGFTQLSSYQSHERTHSG-EKPFLCPRCGRMFSDPSSFRRHQRAH----EGVKPYRC--EKCGKDFR 318
Cdd:COG5048   255 ssASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVnhsgESLKPFSCpySLCGKLFS 334

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375456814 319 QPADLAMHRRVHTGDRPFKC--LQCDKTFVASWDLKRHALVH-----SGQRPFRCE--ECGRAFAERASLTKHSRMHSGE 389
Cdd:COG5048   335 RNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSF 414

                         410       420       430
                  ....*....|....*....|....*....|..
gi 1375456814 390 RP--FHCNACGKSFVVLSSLRKHERTHRSNET 419
Cdd:COG5048   415 RPynCKNPPCSKSFNRHYNLIPHKKIHTNHAP 446
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
248-598 2.31e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.63  E-value: 2.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375456814 248 AQKPYRCPACGKGFTQLSSYQSHERTHSGEKPFLCPRCGR--MFSDPSSFRRHQRAHEGVKPYRCEKCGKDFRQPADLAM 325
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375456814 326 HRRVHTGDR----PFKCLQCDKTFVaSWDLKRHALVHSGQRPFRceECGRAFAERA----------------------SL 379
Cdd:COG5048   110 LSSSSSNSNdnnlLSSHSLPPSSRD-PQLPDLLSISNLRNNPLP--GNNSSSVNTPqsnslhpplpanslskdpssnlSL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375456814 380 TKHSRMHSGERPFHCNACGKSFVVLSSLRKHERTHRSNETTGAAPQQELVLGLALPVGVVGEGSaapvagagvgDAPAGL 459
Cdd:COG5048   187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSS----------SDSSSS 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375456814 460 LGLPPESG----GVVATQWQVVGMTVEhvecqdagvgEAPSTlgdagevggeetdekppQFVCRECKETFSTLTLLRRHE 535
Cdd:COG5048   257 ASESPRSSlptaSSQSSSPNESDSSSE----------KGFSL-----------------PIKSKQCNISFSRSSPLTRHL 309

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1375456814 536 RSH----PELRPFPCT--QCGKSFSDRAGLRKHSRTHSSVRPYSC--SQCPKAFLSASDLRKHERTHPVPI 598
Cdd:COG5048   310 RSVnhsgESLKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYKD 380
zf-H2C2_2 pfam13465
Zinc-finger double domain;
210-235 1.12e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.12e-04
                          10        20
                  ....*....|....*....|....*.
gi 1375456814 210 DLRNHERSHTGERPFLCSECGKSFSR 235
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
531-554 2.49e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.49e-03
                          10        20
                  ....*....|....*....|....
gi 1375456814 531 LRRHERSHPELRPFPCTQCGKSFS 554
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
65-419 1.15e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.58  E-value: 1.15e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375456814  65 KAEEASGDKVSASVAKPRPYACPLCPKAYKTAPELRSHGRSHTGEKPFPCPECGR--RFMQPVCLRVHLASHAGELPFRC 142
Cdd:COG5048    15 VLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLN 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375456814 143 TH-CPKAYGTLSKLKIHQRGHTGERPYACPDCGKSFADPSVFRKHRRTHAGLRPYSCERCGKAYAELK------------ 209
Cdd:COG5048    95 SKsLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpplpan 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375456814 210 ----------DLRNHERSHTGERPFLCSECGKSFSR-------------SSSLTCHQRIHA------------------- 247
Cdd:COG5048   175 slskdpssnlSLLISSNVSTSIPSSSENSPLSSSYSipssssdqnlensSSSLPLTTNSQLspksllsqspsslsssdss 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375456814 248 --AQKPYRCPACGKGFTQLSSYQSHERTHSG-EKPFLCPRCGRMFSDPSSFRRHQRAH----EGVKPYRC--EKCGKDFR 318
Cdd:COG5048   255 ssASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVnhsgESLKPFSCpySLCGKLFS 334

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375456814 319 QPADLAMHRRVHTGDRPFKC--LQCDKTFVASWDLKRHALVH-----SGQRPFRCE--ECGRAFAERASLTKHSRMHSGE 389
Cdd:COG5048   335 RNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSF 414

                         410       420       430
                  ....*....|....*....|....*....|..
gi 1375456814 390 RP--FHCNACGKSFVVLSSLRKHERTHRSNET 419
Cdd:COG5048   415 RPynCKNPPCSKSFNRHYNLIPHKKIHTNHAP 446
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
138-299 1.14e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 1.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375456814 138 LPFRCTHCPKAYGTLSKLKIHQRG--HTGE--RPYACP--DCGKSFADPSVFRKHRRTHAGLRPYSC--ERCGKAYAELK 209
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375456814 210 DLRNHERSH-----TGERPFLC--SECGKSFSRSSSLTCHQRIHAAQKP--YRCPACGKGFTQLSSYQSHERTHSGEKPF 280
Cdd:COG5048   368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|....*....
gi 1375456814 281 LCPRCGRMFSDPSSFRRHQ 299
Cdd:COG5048   448 LCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
248-598 2.31e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.63  E-value: 2.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375456814 248 AQKPYRCPACGKGFTQLSSYQSHERTHSGEKPFLCPRCGR--MFSDPSSFRRHQRAHEGVKPYRCEKCGKDFRQPADLAM 325
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375456814 326 HRRVHTGDR----PFKCLQCDKTFVaSWDLKRHALVHSGQRPFRceECGRAFAERA----------------------SL 379
Cdd:COG5048   110 LSSSSSNSNdnnlLSSHSLPPSSRD-PQLPDLLSISNLRNNPLP--GNNSSSVNTPqsnslhpplpanslskdpssnlSL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375456814 380 TKHSRMHSGERPFHCNACGKSFVVLSSLRKHERTHRSNETTGAAPQQELVLGLALPVGVVGEGSaapvagagvgDAPAGL 459
Cdd:COG5048   187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSS----------SDSSSS 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375456814 460 LGLPPESG----GVVATQWQVVGMTVEhvecqdagvgEAPSTlgdagevggeetdekppQFVCRECKETFSTLTLLRRHE 535
Cdd:COG5048   257 ASESPRSSlptaSSQSSSPNESDSSSE----------KGFSL-----------------PIKSKQCNISFSRSSPLTRHL 309

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1375456814 536 RSH----PELRPFPCT--QCGKSFSDRAGLRKHSRTHSSVRPYSC--SQCPKAFLSASDLRKHERTHPVPI 598
Cdd:COG5048   310 RSVnhsgESLKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYKD 380
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 192-275 3.13e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.63  E-value: 3.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375456814 192 GLRPYSCE--RCGKAYAELKDLRNHeRSHtgerpflcSECGKSFSRSSSLTCHQRIHAAQKPYRCPACGKGFTQLSSYQS 269
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1375456814 270 HeRTHS 275
Cdd:COG5189   417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
210-235 1.12e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.12e-04
                          10        20
                  ....*....|....*....|....*.
gi 1375456814 210 DLRNHERSHTGERPFLCSECGKSFSR 235
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 321-414 2.82e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 2.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375456814 321 ADLAMHRRVHTGDRPFKC--LQCDKTFVASWDLKRHALvHSGQRPfrceecgrAFAERASLTKHSRMHSGERPFHCNACG 398
Cdd:COG5189   335 IDTPSRMLKVKDGKPYKCpvEGCNKKYKNQNGLKYHML-HGHQNQ--------KLHENPSPEKMNIFSAKDKPYRCEVCD 405

                          90
                  ....*....|....*.
gi 1375456814 399 KSFVVLSSLRKHeRTH 414
Cdd:COG5189   406 KRYKNLNGLKYH-RKH 420
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 136-219 4.35e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 4.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375456814 136 GELPFRC--THCPKAYGTLSKLKIHQR-GHTGERPYACPDcgksfadPSvfrKHRRTHAGLRPYSCERCGKAYAELKDLR 212
Cdd:COG5189   346 DGKPYKCpvEGCNKKYKNQNGLKYHMLhGHQNQKLHENPS-------PE---KMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ....*..
gi 1375456814 213 NHeRSHT 219
Cdd:COG5189   416 YH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
155-178 5.39e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.39e-04
                          10        20
                  ....*....|....*....|....
gi 1375456814 155 LKIHQRGHTGERPYACPDCGKSFA 178
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
98-121 7.90e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.90e-04
                          10        20
                  ....*....|....*....|....
gi 1375456814  98 ELRSHGRSHTGEKPFPCPECGRRF 121
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 249-327 1.00e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375456814 249 QKPYRCP--ACGKGFTQLSSYQSHeRTHSGEKPFLCPRcgrmfSDPSSfrrHQRAHEGVKPYRCEKCGKDFRQPADLAMH 326
Cdd:COG5189   347 GKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQKLHEN-----PSPEK---MNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417


                  .
gi 1375456814 327 R 327
Cdd:COG5189   418 R 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
378-402 1.15e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.15e-03
                          10        20
                  ....*....|....*....|....*
gi 1375456814 378 SLTKHSRMHSGERPFHCNACGKSFV 402
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
322-346 2.24e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.24e-03
                          10        20
                  ....*....|....*....|....*
gi 1375456814 322 DLAMHRRVHTGDRPFKCLQCDKTFV 346
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
531-554 2.49e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.49e-03
                          10        20
                  ....*....|....*....|....
gi 1375456814 531 LRRHERSHPELRPFPCTQCGKSFS 554
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 168-190 2.68e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.68e-03
                          10        20
                  ....*....|....*....|...
gi 1375456814 168 YACPDCGKSFADPSVFRKHRRTH 190
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
350-374 4.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.72e-03
                          10        20
                  ....*....|....*....|....*
gi 1375456814 350 DLKRHALVHSGQRPFRCEECGRAFA 374
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 544-566 4.88e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.88e-03
                          10        20
                  ....*....|....*....|...
gi 1375456814 544 FPCTQCGKSFSDRAGLRKHSRTH 566
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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