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Conserved domains on  [gi|1343871085|ref|NP_001347756|]
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prospero homeobox protein 1 [Mus musculus]

Protein Classification

homeo-prospero domain-containing protein( domain architecture ID 10523599)

homeo-prospero domain (HPD)-containing protein similar to Drosophila melanogaster homeobox protein prospero, a homeodomain protein that controls neuronal identity

CATH:  1.10.10.500
Gene Ontology:  GO:0003677|GO:0003700
PubMed:  12429095|15837198

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HPD pfam05044
Homeo-prospero domain; Prospero is a large drosophila transcription factor protein that is ...
 579-732 7.60e-113

Homeo-prospero domain; Prospero is a large drosophila transcription factor protein that is expressed in all neural lineages of drosophila embryos. It is needed for correct expression of several neural proteins and in determining the cell fates of neural stem cells. homologs of prospero are found in a wide range of animals including humans with the highest level of similarity being found in the C-terminal 160 amino acids. This region was identified as containing an atypical homeobox domain followed by a prospero domain. However, the structure shows that these two regions form a single stable structural domain as defined here. This homeo-prospero domain binds to DNA.


:

Pssm-ID: 461534  Cd Length: 154  Bit Score: 337.48  E-value: 7.60e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343871085 579 GLSPNHLKKAKLMFFYTRYPSSNMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAINDGVTSTEELSITRD 658
Cdd:pfam05044   1 GLTPMHLKKAKLMFFYTRYPSSNVLKTYFPDVKFNRCNTSQLIKWFSNFREFYYIQMEKFARQALSEGVTDAEDLLVSRD 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1343871085 659 CELYRALNMHYNKANDFEVPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQ 732
Cdd:pfam05044  81 SELFRVLNLHYNKNNDFEVPDRFLEVVQLTLREFFNAIQAGKDSDPSWKKAIYKVICKLDSEVPEIFKSPNFLE 154
 
Name Accession Description Interval E-value
HPD pfam05044
Homeo-prospero domain; Prospero is a large drosophila transcription factor protein that is ...
 579-732 7.60e-113

Homeo-prospero domain; Prospero is a large drosophila transcription factor protein that is expressed in all neural lineages of drosophila embryos. It is needed for correct expression of several neural proteins and in determining the cell fates of neural stem cells. homologs of prospero are found in a wide range of animals including humans with the highest level of similarity being found in the C-terminal 160 amino acids. This region was identified as containing an atypical homeobox domain followed by a prospero domain. However, the structure shows that these two regions form a single stable structural domain as defined here. This homeo-prospero domain binds to DNA.


Pssm-ID: 461534  Cd Length: 154  Bit Score: 337.48  E-value: 7.60e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343871085 579 GLSPNHLKKAKLMFFYTRYPSSNMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAINDGVTSTEELSITRD 658
Cdd:pfam05044   1 GLTPMHLKKAKLMFFYTRYPSSNVLKTYFPDVKFNRCNTSQLIKWFSNFREFYYIQMEKFARQALSEGVTDAEDLLVSRD 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1343871085 659 CELYRALNMHYNKANDFEVPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQ 732
Cdd:pfam05044  81 SELFRVLNLHYNKNNDFEVPDRFLEVVQLTLREFFNAIQAGKDSDPSWKKAIYKVICKLDSEVPEIFKSPNFLE 154
 
Name Accession Description Interval E-value
HPD pfam05044
Homeo-prospero domain; Prospero is a large drosophila transcription factor protein that is ...
 579-732 7.60e-113

Homeo-prospero domain; Prospero is a large drosophila transcription factor protein that is expressed in all neural lineages of drosophila embryos. It is needed for correct expression of several neural proteins and in determining the cell fates of neural stem cells. homologs of prospero are found in a wide range of animals including humans with the highest level of similarity being found in the C-terminal 160 amino acids. This region was identified as containing an atypical homeobox domain followed by a prospero domain. However, the structure shows that these two regions form a single stable structural domain as defined here. This homeo-prospero domain binds to DNA.


Pssm-ID: 461534  Cd Length: 154  Bit Score: 337.48  E-value: 7.60e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343871085 579 GLSPNHLKKAKLMFFYTRYPSSNMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAINDGVTSTEELSITRD 658
Cdd:pfam05044   1 GLTPMHLKKAKLMFFYTRYPSSNVLKTYFPDVKFNRCNTSQLIKWFSNFREFYYIQMEKFARQALSEGVTDAEDLLVSRD 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1343871085 659 CELYRALNMHYNKANDFEVPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQ 732
Cdd:pfam05044  81 SELFRVLNLHYNKNNDFEVPDRFLEVVQLTLREFFNAIQAGKDSDPSWKKAIYKVICKLDSEVPEIFKSPNFLE 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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