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Conserved domains on  [gi|1327848652|ref|NP_001346399|]
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transmembrane protein 19 isoform 1 [Mus musculus]

Protein Classification

DUF92 domain-containing protein( domain architecture ID 10487781)

DUF92 domain-containing protein similar to vertebrate transmembrane protein 19 (TMEM19) and Arabidopsis thaliana protein PGR (plasma membrane glucose-responsive regulator), which is involved in the glucose-triggered developmental leaf growth process

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF92 pfam01940
Integral membrane protein DUF92; Members of this family have several predicted transmembrane ...
 74-337 9.99e-76

Integral membrane protein DUF92; Members of this family have several predicted transmembrane helices. One member of the family has been characterized as protein PGR (AtPGR). PGR is suggested to be a potential glucose-responsive regulator in carbohydrate metabolism in plants. This entry also includes protein VTE6, which is a Pphytyl-phosphate kinase catalysing the conversion of phytyl-monophosphate to phytyl-diphosphate.


:

Pssm-ID: 460391  Cd Length: 237  Bit Score: 233.15  E-value: 9.99e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848652  74 VVPVVIACNGFKKKSLDHSGALGGLVVGFILTIANFS--FFTSLMTFFLSSSKLTKWRGNIKKQLDSEYKEGGQRNWVQV 151
Cdd:pfam01940   1 LLSLLLAYLAYRKKSLTPSGALAAVLVGTLIALGPGGwrWFLLLLVFFLLGSLATKYKKDRKAALGLAEGKGGARGAVQV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848652 152 FCNGAVPTELALLYMiengpgempidFSKQHTASWMCLSLLAALASSAGDTWASEVAPVLSKsSPRLITTWEKVPVGTNG 231
Cdd:pfam01940  81 LANGGVAALLALLYA-----------FTYQPLSPLLLLGFVGSYAAALADTWASEIGKLLSK-KPRLITTLKPVPPGTNG 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848652 232 GVTAVGLASSLLGGTFVGLAYFLTQLvfvndldisapqwpIIAFGGVAGLFGSLVDSFLGATMQFSGLDERTGLVVsspT 311
Cdd:pfam01940 149 GVSLLGTLAGLLGALLIGLLYALGLI--------------LILLVTLAGFLGSLLDSLLGATLQASYYDKRTGKIV---E 211

                         250       260
                  ....*....|....*....|....*.
gi 1327848652 312 QETKHIAGKPILDNNAVNLFSSVLVA 337
Cdd:pfam01940 212 GPGRKISGWDWLDNNAVNFLSTLIGA 237
 
Name Accession Description Interval E-value
DUF92 pfam01940
Integral membrane protein DUF92; Members of this family have several predicted transmembrane ...
 74-337 9.99e-76

Integral membrane protein DUF92; Members of this family have several predicted transmembrane helices. One member of the family has been characterized as protein PGR (AtPGR). PGR is suggested to be a potential glucose-responsive regulator in carbohydrate metabolism in plants. This entry also includes protein VTE6, which is a Pphytyl-phosphate kinase catalysing the conversion of phytyl-monophosphate to phytyl-diphosphate.


Pssm-ID: 460391  Cd Length: 237  Bit Score: 233.15  E-value: 9.99e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848652  74 VVPVVIACNGFKKKSLDHSGALGGLVVGFILTIANFS--FFTSLMTFFLSSSKLTKWRGNIKKQLDSEYKEGGQRNWVQV 151
Cdd:pfam01940   1 LLSLLLAYLAYRKKSLTPSGALAAVLVGTLIALGPGGwrWFLLLLVFFLLGSLATKYKKDRKAALGLAEGKGGARGAVQV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848652 152 FCNGAVPTELALLYMiengpgempidFSKQHTASWMCLSLLAALASSAGDTWASEVAPVLSKsSPRLITTWEKVPVGTNG 231
Cdd:pfam01940  81 LANGGVAALLALLYA-----------FTYQPLSPLLLLGFVGSYAAALADTWASEIGKLLSK-KPRLITTLKPVPPGTNG 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848652 232 GVTAVGLASSLLGGTFVGLAYFLTQLvfvndldisapqwpIIAFGGVAGLFGSLVDSFLGATMQFSGLDERTGLVVsspT 311
Cdd:pfam01940 149 GVSLLGTLAGLLGALLIGLLYALGLI--------------LILLVTLAGFLGSLLDSLLGATLQASYYDKRTGKIV---E 211

                         250       260
                  ....*....|....*....|....*.
gi 1327848652 312 QETKHIAGKPILDNNAVNLFSSVLVA 337
Cdd:pfam01940 212 GPGRKISGWDWLDNNAVNFLSTLIGA 237
COG1836 COG1836
Cytidylyltransferase family enzyme [General function prediction only];
64-339 1.29e-51

Cytidylyltransferase family enzyme [General function prediction only];


Pssm-ID: 441441  Cd Length: 243  Bit Score: 171.51  E-value: 1.29e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848652  64 VSPWRWLFSVVVPVVIACNGFKKKSLDHSGALGGLVVGFIL-TIANFSFFTSLMTFFLSSSKLTKWRGNIKKQLDSEYKE 142
Cdd:COG1836     2 VLLNPLLLALALSLLLGYLAYRKKLLTLSGALAAVLLGTLIiGLGGWGWFLLLLLFFILGSLLTKYGYKRKEALGIAEEK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848652 143 GGQRNWVQVFCNGAVPTELALLYMIengpgempidfsKQHTASWMCLSLLAALASSAGDTWASEVApVLSKSSPRLITTW 222
Cdd:COG1836    82 GGARGAGNVLANGGVALLAALLYAA------------TPDDSPLFLLAFAGSLATALADTWASEIG-VLSGKRPRLITTL 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848652 223 EKVPVGTNGGVTAVGLASSLLGGTFVGLAYFLTQLVfvndldisaPQWPIIAFGGVAGLFGSLVDSFLGATMQfsglder 302
Cdd:COG1836   149 KPVPPGTSGGVSLLGTLAGLLGALLIALLAWLLGLI---------DSLLGLLIVVLAGFLGTLVDSLLGATLQ------- 212

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1327848652 303 tglvvssptqetkhiAGKPILDNNAVNLFSSVLVALL 339
Cdd:COG1836   213 ---------------NKYGWLTNDGVNFLATLIGALL 234
 
Name Accession Description Interval E-value
DUF92 pfam01940
Integral membrane protein DUF92; Members of this family have several predicted transmembrane ...
 74-337 9.99e-76

Integral membrane protein DUF92; Members of this family have several predicted transmembrane helices. One member of the family has been characterized as protein PGR (AtPGR). PGR is suggested to be a potential glucose-responsive regulator in carbohydrate metabolism in plants. This entry also includes protein VTE6, which is a Pphytyl-phosphate kinase catalysing the conversion of phytyl-monophosphate to phytyl-diphosphate.


Pssm-ID: 460391  Cd Length: 237  Bit Score: 233.15  E-value: 9.99e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848652  74 VVPVVIACNGFKKKSLDHSGALGGLVVGFILTIANFS--FFTSLMTFFLSSSKLTKWRGNIKKQLDSEYKEGGQRNWVQV 151
Cdd:pfam01940   1 LLSLLLAYLAYRKKSLTPSGALAAVLVGTLIALGPGGwrWFLLLLVFFLLGSLATKYKKDRKAALGLAEGKGGARGAVQV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848652 152 FCNGAVPTELALLYMiengpgempidFSKQHTASWMCLSLLAALASSAGDTWASEVAPVLSKsSPRLITTWEKVPVGTNG 231
Cdd:pfam01940  81 LANGGVAALLALLYA-----------FTYQPLSPLLLLGFVGSYAAALADTWASEIGKLLSK-KPRLITTLKPVPPGTNG 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848652 232 GVTAVGLASSLLGGTFVGLAYFLTQLvfvndldisapqwpIIAFGGVAGLFGSLVDSFLGATMQFSGLDERTGLVVsspT 311
Cdd:pfam01940 149 GVSLLGTLAGLLGALLIGLLYALGLI--------------LILLVTLAGFLGSLLDSLLGATLQASYYDKRTGKIV---E 211

                         250       260
                  ....*....|....*....|....*.
gi 1327848652 312 QETKHIAGKPILDNNAVNLFSSVLVA 337
Cdd:pfam01940 212 GPGRKISGWDWLDNNAVNFLSTLIGA 237
COG1836 COG1836
Cytidylyltransferase family enzyme [General function prediction only];
64-339 1.29e-51

Cytidylyltransferase family enzyme [General function prediction only];


Pssm-ID: 441441  Cd Length: 243  Bit Score: 171.51  E-value: 1.29e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848652  64 VSPWRWLFSVVVPVVIACNGFKKKSLDHSGALGGLVVGFIL-TIANFSFFTSLMTFFLSSSKLTKWRGNIKKQLDSEYKE 142
Cdd:COG1836     2 VLLNPLLLALALSLLLGYLAYRKKLLTLSGALAAVLLGTLIiGLGGWGWFLLLLLFFILGSLLTKYGYKRKEALGIAEEK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848652 143 GGQRNWVQVFCNGAVPTELALLYMIengpgempidfsKQHTASWMCLSLLAALASSAGDTWASEVApVLSKSSPRLITTW 222
Cdd:COG1836    82 GGARGAGNVLANGGVALLAALLYAA------------TPDDSPLFLLAFAGSLATALADTWASEIG-VLSGKRPRLITTL 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327848652 223 EKVPVGTNGGVTAVGLASSLLGGTFVGLAYFLTQLVfvndldisaPQWPIIAFGGVAGLFGSLVDSFLGATMQfsglder 302
Cdd:COG1836   149 KPVPPGTSGGVSLLGTLAGLLGALLIALLAWLLGLI---------DSLLGLLIVVLAGFLGTLVDSLLGATLQ------- 212

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1327848652 303 tglvvssptqetkhiAGKPILDNNAVNLFSSVLVALL 339
Cdd:COG1836   213 ---------------NKYGWLTNDGVNFLATLIGALL 234
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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