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Conserved domains on  [gi|1318663248|ref|NP_001346244|]
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MAP7 domain-containing protein 2 isoform 9 [Mus musculus]

Protein Classification

MAP7 domain-containing protein( domain architecture ID 12064852)

MAP7 domain-containing protein such as MAP7D1 (microtubule-associated protein 7 domain containing 1) identified as a novel substrate of doublecortin-like kinase 1 (DCLK1)

Gene Ontology:  GO:0005737

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 368-533 7.85e-20

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


:

Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 86.63  E-value: 7.85e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663248 368 KPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERLEKEERERLEKEELKRKAEEERLRIEmaykreqekkrqeeEEKRKA 447
Cdd:pfam05672   1 KPSAGTTDAEEAARILAEKRRQAREQREREEQERLEKEEEERLRKEELRRRAEEERARRE--------------EEARRL 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663248 448 EEKAKEKAEEELLSKEKQEKEKQEQEKKEKAMIEKQKEAAEAKAQDAAKQMRLEREQIMLQIEQERLERKKRIDEIMKRT 527
Cdd:pfam05672  67 EEERRREEEERQRKAEEEAEEREQREQEEQERLQKQKEEAEAKAREEAERQRQEREKIMQQEEQERLERKKRIEEIMKRT 146


                  ....*.
gi 1318663248 528 RKSDAS 533
Cdd:pfam05672 147 RKSDQA 152
DUF5401 super family cl38662
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 75-168 5.84e-06

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


The actual alignment was detected with superfamily member pfam17380:

Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 49.74  E-value: 5.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663248  75 ERQRLAKERREEREKCLAAREQQILEKQKRAKLqYEKQIEERWRKLEEqrqrEDQKRAAVEEKRKQKLREEEERLEAMMR 154
Cdd:pfam17380 485 DRKRAEEQRRKILEKELEERKQAMIEEERKRKL-LEKEMEERQKAIYE----EERRREAEEERRKQQEMEERRRIQEQMR 559

                          90
                  ....*....|....
gi 1318663248 155 RSLERTQQLELKKK 168
Cdd:pfam17380 560 KATEERSRLEAMER 573
 
Name Accession Description Interval E-value
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 368-533 7.85e-20

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 86.63  E-value: 7.85e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663248 368 KPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERLEKEERERLEKEELKRKAEEERLRIEmaykreqekkrqeeEEKRKA 447
Cdd:pfam05672   1 KPSAGTTDAEEAARILAEKRRQAREQREREEQERLEKEEEERLRKEELRRRAEEERARRE--------------EEARRL 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663248 448 EEKAKEKAEEELLSKEKQEKEKQEQEKKEKAMIEKQKEAAEAKAQDAAKQMRLEREQIMLQIEQERLERKKRIDEIMKRT 527
Cdd:pfam05672  67 EEERRREEEERQRKAEEEAEEREQREQEEQERLQKQKEEAEAKAREEAERQRQEREKIMQQEEQERLERKKRIEEIMKRT 146


                  ....*.
gi 1318663248 528 RKSDAS 533
Cdd:pfam05672 147 RKSDQA 152
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 75-168 5.84e-06

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 49.74  E-value: 5.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663248  75 ERQRLAKERREEREKCLAAREQQILEKQKRAKLqYEKQIEERWRKLEEqrqrEDQKRAAVEEKRKQKLREEEERLEAMMR 154
Cdd:pfam17380 485 DRKRAEEQRRKILEKELEERKQAMIEEERKRKL-LEKEMEERQKAIYE----EERRREAEEERRKQQEMEERRRIQEQMR 559

                          90
                  ....*....|....
gi 1318663248 155 RSLERTQQLELKKK 168
Cdd:pfam17380 560 KATEERSRLEAMER 573
 
Name Accession Description Interval E-value
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 368-533 7.85e-20

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 86.63  E-value: 7.85e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663248 368 KPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERLEKEERERLEKEELKRKAEEERLRIEmaykreqekkrqeeEEKRKA 447
Cdd:pfam05672   1 KPSAGTTDAEEAARILAEKRRQAREQREREEQERLEKEEEERLRKEELRRRAEEERARRE--------------EEARRL 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663248 448 EEKAKEKAEEELLSKEKQEKEKQEQEKKEKAMIEKQKEAAEAKAQDAAKQMRLEREQIMLQIEQERLERKKRIDEIMKRT 527
Cdd:pfam05672  67 EEERRREEEERQRKAEEEAEEREQREQEEQERLQKQKEEAEAKAREEAERQRQEREKIMQQEEQERLERKKRIEEIMKRT 146


                  ....*.
gi 1318663248 528 RKSDAS 533
Cdd:pfam05672 147 RKSDQA 152
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 75-168 5.84e-06

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 49.74  E-value: 5.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663248  75 ERQRLAKERREEREKCLAAREQQILEKQKRAKLqYEKQIEERWRKLEEqrqrEDQKRAAVEEKRKQKLREEEERLEAMMR 154
Cdd:pfam17380 485 DRKRAEEQRRKILEKELEERKQAMIEEERKRKL-LEKEMEERQKAIYE----EERRREAEEERRKQQEMEERRRIQEQMR 559

                          90
                  ....*....|....
gi 1318663248 155 RSLERTQQLELKKK 168
Cdd:pfam17380 560 KATEERSRLEAMER 573
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 75-162 3.96e-03

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 38.48  E-value: 3.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663248  75 ERQRLAKERREEREKclaAREQQILEKQKRAKLQYEKQIEERWRKLEEQRQREDQKRAAvEEKRKQKLREEEERLEAMMR 154
Cdd:pfam05672  18 EKRRQAREQREREEQ---ERLEKEEEERLRKEELRRRAEEERARREEEARRLEEERRRE-EEERQRKAEEEAEEREQREQ 93


                  ....*...
gi 1318663248 155 RSLERTQQ 162
Cdd:pfam05672  94 EEQERLQK 101
DDRGK pfam09756
DDRGK domain; This is a family of proteins of approximately 300 residues, found in plants and ...
 72-141 7.28e-03

DDRGK domain; This is a family of proteins of approximately 300 residues, found in plants and vertebrates. They contain a highly conserved DDRGK motif.


Pssm-ID: 370664 [Multi-domain]  Cd Length: 188  Bit Score: 38.10  E-value: 7.28e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663248  72 KSDERQRLAKERREEREKclaarEQQILEKQKRAKLQYEKQIEERWRKLEEQRQREDQKRAAVEEKRKQK 141
Cdd:pfam09756   6 KKRAKLELKEAKRQQREA-----EEEEREEREKLEEKREEEYKEREEREEEAEKEKEEEERKQEEEQERK 70
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 75-168 7.78e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 39.72  E-value: 7.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663248  75 ERQRLAKERREEREkclAAREQQILEKQKRAKLQYEKQI------------EERWRKLEEQRQREDQKRAAVEEKRKQKL 142
Cdd:pfam17380 386 ERQQKNERVRQELE---AARKVKILEEERQRKIQQQKVEmeqiraeqeearQREVRRLEEERAREMERVRLEEQERQQQV 462

                          90       100
                  ....*....|....*....|....*.
gi 1318663248 143 REEEERLEAMMRRSLERTQQLELKKK 168
Cdd:pfam17380 463 ERLRQQEEERKRKKLELEKEKRDRKR 488
ARGLU pfam15346
Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is ...
 75-168 9.84e-03

Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is required for the oestrogen-dependent expression of ESR1 target genes. It functions in cooperation with MED1. The family of proteins is found in eukaryotes.


Pssm-ID: 405931 [Multi-domain]  Cd Length: 151  Bit Score: 37.34  E-value: 9.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663248  75 ERQRLAKERRE--EREKCLAAREQQILEKQKRAKL-QYEKQIEERWRKLEE-QRQREDQKRAAVEEKRKQKlrEEEERLE 150
Cdd:pfam15346  46 ARKIMEKQVLEelEREREAELEEERRKEEEERKKReELERILEENNRKIEEaQRKEAEERLAMLEEQRRMK--EERQRRE 123

                          90
                  ....*....|....*...
gi 1318663248 151 AMMRRSLERTQQLELKKK 168
Cdd:pfam15346 124 KEEEEREKREQQKILNKK 141
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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