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Conserved domains on  [gi|1318663207|ref|NP_001346239|]
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MAP7 domain-containing protein 2 isoform 5 [Mus musculus]

Protein Classification

MAP7 domain-containing protein( domain architecture ID 12064852)

MAP7 domain-containing protein such as MAP7D1 (microtubule-associated protein 7 domain containing 1) identified as a novel substrate of doublecortin-like kinase 1 (DCLK1)

Gene Ontology:  GO:0005737

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 438-589 5.58e-12

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


:

Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 64.29  E-value: 5.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663207 438 KPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERLEKEERERLEKEELKRKAEEERLRIEmaykreqekkrqeeEEKRKA 517
Cdd:pfam05672   1 KPSAGTTDAEEAARILAEKRRQAREQREREEQERLEKEEEERLRKEELRRRAEEERARRE--------------EEARRL 66

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1318663207 518 EEKAKEKAEEELLSKEKQEKEKQEQEKKEKAMIEKQKEAAEAKAQDAAKQMRLEREQIMLQIEQERLERKKK 589
Cdd:pfam05672  67 EEERRREEEERQRKAEEEAEEREQREQEEQERLQKQKEEAEAKAREEAERQRQEREKIMQQEEQERLERKKR 138
DUF5401 super family cl38662
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 75-168 3.05e-06

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


The actual alignment was detected with superfamily member pfam17380:

Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 50.89  E-value: 3.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663207  75 ERQRLAKERREEREKCLAAREQQILEKQKRAKLqYEKQIEERWRKLEEqrqrEDQKRAAVEEKRKQKLREEEERLEAMMR 154
Cdd:pfam17380 485 DRKRAEEQRRKILEKELEERKQAMIEEERKRKL-LEKEMEERQKAIYE----EERRREAEEERRKQQEMEERRRIQEQMR 559

                          90
                  ....*....|....
gi 1318663207 155 RSLERTQQLELKKK 168
Cdd:pfam17380 560 KATEERSRLEAMER 573
 
Name Accession Description Interval E-value
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 438-589 5.58e-12

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 64.29  E-value: 5.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663207 438 KPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERLEKEERERLEKEELKRKAEEERLRIEmaykreqekkrqeeEEKRKA 517
Cdd:pfam05672   1 KPSAGTTDAEEAARILAEKRRQAREQREREEQERLEKEEEERLRKEELRRRAEEERARRE--------------EEARRL 66

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1318663207 518 EEKAKEKAEEELLSKEKQEKEKQEQEKKEKAMIEKQKEAAEAKAQDAAKQMRLEREQIMLQIEQERLERKKK 589
Cdd:pfam05672  67 EEERRREEEERQRKAEEEAEEREQREQEEQERLQKQKEEAEAKAREEAERQRQEREKIMQQEEQERLERKKR 138
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 75-168 3.05e-06

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 50.89  E-value: 3.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663207  75 ERQRLAKERREEREKCLAAREQQILEKQKRAKLqYEKQIEERWRKLEEqrqrEDQKRAAVEEKRKQKLREEEERLEAMMR 154
Cdd:pfam17380 485 DRKRAEEQRRKILEKELEERKQAMIEEERKRKL-LEKEMEERQKAIYE----EERRREAEEERRKQQEMEERRRIQEQMR 559

                          90
                  ....*....|....
gi 1318663207 155 RSLERTQQLELKKK 168
Cdd:pfam17380 560 KATEERSRLEAMER 573
PTZ00121 PTZ00121
MAEBL; Provisional
 47-168 1.12e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.82  E-value: 1.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663207   47 AKSAEAASGRASQSTPRSagmDGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRAKLQYE---KQIEERWRKLEEQ 123
Cdd:PTZ00121  1314 AKKADEAKKKAEEAKKKA---DAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEeakKKADAAKKKAEEK 1390

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1318663207  124 RQREDQKRAAVEEKRK----QKLREEEERLEAMMRRSLERTQQLELKKK 168
Cdd:PTZ00121  1391 KKADEAKKKAEEDKKKadelKKAAAAKKKADEAKKKAEEKKKADEAKKK 1439
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 75-168 3.04e-03

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 40.60  E-value: 3.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663207  75 ERQRLAKERREEREkclaAREQQILEKQKRAKLQYEKQIEERWRKLEEQR-QREDQKRAAVEEKRKQKLREEEERLEAMM 153
Cdd:TIGR02794  66 EQERQKKLEQQAEE----AEKQRAAEQARQKELEQRAAAEKAAKQAEQAAkQAEEKQKQAEEAKAKQAAEAKAKAEAEAE 141

                          90
                  ....*....|....*.
gi 1318663207 154 RRSLERTQ-QLELKKK 168
Cdd:TIGR02794 142 RKAKEEAAkQAEEEAK 157
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
75-164 4.71e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 40.52  E-value: 4.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663207  75 ERQRLAKERREEREKCLAAREQQILEKQKRAKLQyekQIEERWRKLEEQRQREDQKRAAVEEKRKQKLREEEERLEAMMR 154
Cdd:COG4717   109 AELEELREELEKLEKLLQLLPLYQELEALEAELA---ELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQ 185

                          90
                  ....*....|
gi 1318663207 155 RSLERTQQLE 164
Cdd:COG4717   186 LSLATEEELQ 195
 
Name Accession Description Interval E-value
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 438-589 5.58e-12

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 64.29  E-value: 5.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663207 438 KPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERLEKEERERLEKEELKRKAEEERLRIEmaykreqekkrqeeEEKRKA 517
Cdd:pfam05672   1 KPSAGTTDAEEAARILAEKRRQAREQREREEQERLEKEEEERLRKEELRRRAEEERARRE--------------EEARRL 66

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1318663207 518 EEKAKEKAEEELLSKEKQEKEKQEQEKKEKAMIEKQKEAAEAKAQDAAKQMRLEREQIMLQIEQERLERKKK 589
Cdd:pfam05672  67 EEERRREEEERQRKAEEEAEEREQREQEEQERLQKQKEEAEAKAREEAERQRQEREKIMQQEEQERLERKKR 138
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 75-168 3.05e-06

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 50.89  E-value: 3.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663207  75 ERQRLAKERREEREKCLAAREQQILEKQKRAKLqYEKQIEERWRKLEEqrqrEDQKRAAVEEKRKQKLREEEERLEAMMR 154
Cdd:pfam17380 485 DRKRAEEQRRKILEKELEERKQAMIEEERKRKL-LEKEMEERQKAIYE----EERRREAEEERRKQQEMEERRRIQEQMR 559

                          90
                  ....*....|....
gi 1318663207 155 RSLERTQQLELKKK 168
Cdd:pfam17380 560 KATEERSRLEAMER 573
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 75-162 4.17e-04

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 41.56  E-value: 4.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663207  75 ERQRLAKERREEREKclaAREQQILEKQKRAKLQYEKQIEERWRKLEEQRQREDQKRAAvEEKRKQKLREEEERLEAMMR 154
Cdd:pfam05672  18 EKRRQAREQREREEQ---ERLEKEEEERLRKEELRRRAEEERARREEEARRLEEERRRE-EEERQRKAEEEAEEREQREQ 93


                  ....*...
gi 1318663207 155 RSLERTQQ 162
Cdd:pfam05672  94 EEQERLQK 101
ARGLU pfam15346
Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is ...
 75-168 5.13e-04

Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is required for the oestrogen-dependent expression of ESR1 target genes. It functions in cooperation with MED1. The family of proteins is found in eukaryotes.


Pssm-ID: 405931 [Multi-domain]  Cd Length: 151  Bit Score: 41.19  E-value: 5.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663207  75 ERQRLAKERRE--EREKCLAAREQQILEKQKRAKL-QYEKQIEERWRKLEE-QRQREDQKRAAVEEKRKQKlrEEEERLE 150
Cdd:pfam15346  46 ARKIMEKQVLEelEREREAELEEERRKEEEERKKReELERILEENNRKIEEaQRKEAEERLAMLEEQRRMK--EERQRRE 123

                          90
                  ....*....|....*...
gi 1318663207 151 AMMRRSLERTQQLELKKK 168
Cdd:pfam15346 124 KEEEEREKREQQKILNKK 141
PTZ00121 PTZ00121
MAEBL; Provisional
 47-168 1.12e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.82  E-value: 1.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663207   47 AKSAEAASGRASQSTPRSagmDGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRAKLQYE---KQIEERWRKLEEQ 123
Cdd:PTZ00121  1314 AKKADEAKKKAEEAKKKA---DAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEeakKKADAAKKKAEEK 1390

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1318663207  124 RQREDQKRAAVEEKRK----QKLREEEERLEAMMRRSLERTQQLELKKK 168
Cdd:PTZ00121  1391 KKADEAKKKAEEDKKKadelKKAAAAKKKADEAKKKAEEKKKADEAKKK 1439
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 74-141 1.40e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 41.44  E-value: 1.40e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1318663207  74 DERQRLAKERREEREKCLAAREQQILEKQKRAKLQYEKQIEERWRKLEEQRQREDQKRAAVEEKRKQK 141
Cdd:pfam13868  58 EEEEEKEEERKEERKRYRQELEEQIEEREQKRQEEYEEKLQEREQMDEIVERIQEEDQAEAEEKLEKQ 125
DDRGK pfam09756
DDRGK domain; This is a family of proteins of approximately 300 residues, found in plants and ...
 72-141 1.45e-03

DDRGK domain; This is a family of proteins of approximately 300 residues, found in plants and vertebrates. They contain a highly conserved DDRGK motif.


Pssm-ID: 370664 [Multi-domain]  Cd Length: 188  Bit Score: 40.41  E-value: 1.45e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663207  72 KSDERQRLAKERREEREKclaarEQQILEKQKRAKLQYEKQIEERWRKLEEQRQREDQKRAAVEEKRKQK 141
Cdd:pfam09756   6 KKRAKLELKEAKRQQREA-----EEEEREEREKLEEKREEEYKEREEREEEAEKEKEEEERKQEEEQERK 70
PTZ00121 PTZ00121
MAEBL; Provisional
 47-168 1.51e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.44  E-value: 1.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663207   47 AKSAEAASGRASQ----STPRSAGMDGFLKSDERQRLAKE-RREEREKCLAAREQQILEKQKRAKLQYEKQIEERWRKLE 121
Cdd:PTZ00121  1612 AKKAEEAKIKAEElkkaEEEKKKVEQLKKKEAEEKKKAEElKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAA 1691

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1318663207  122 EQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKK 168
Cdd:PTZ00121  1692 EALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKE 1738
PTZ00121 PTZ00121
MAEBL; Provisional
 35-168 2.87e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.28  E-value: 2.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663207   35 SEGAAKGLSLLLAKSAEAASGRASQSTPRSAGMDGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRAKLQyeKQIE 114
Cdd:PTZ00121  1324 AEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAK--KKAE 1401

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1318663207  115 ERWRKLEEQRQREDQKRAAVEEKRKQKLREEEERLEammRRSLERTQQLELKKK 168
Cdd:PTZ00121  1402 EDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAK---KKAEEAKKADEAKKK 1452
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 75-168 3.04e-03

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 40.60  E-value: 3.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663207  75 ERQRLAKERREEREkclaAREQQILEKQKRAKLQYEKQIEERWRKLEEQR-QREDQKRAAVEEKRKQKLREEEERLEAMM 153
Cdd:TIGR02794  66 EQERQKKLEQQAEE----AEKQRAAEQARQKELEQRAAAEKAAKQAEQAAkQAEEKQKQAEEAKAKQAAEAKAKAEAEAE 141

                          90
                  ....*....|....*.
gi 1318663207 154 RRSLERTQ-QLELKKK 168
Cdd:TIGR02794 142 RKAKEEAAkQAEEEAK 157
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 74-140 3.25e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 40.29  E-value: 3.25e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663207  74 DERQRLAKERREEREKCLA---AREQQILEKQKRAKLQYEKQIEERWRKLEEQRQREDQKRAAVEEKRKQ 140
Cdd:pfam13868  40 EEERRLDEMMEEERERALEeeeEKEEERKEERKRYRQELEEQIEEREQKRQEEYEEKLQEREQMDEIVER 109
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 75-168 4.17e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 40.49  E-value: 4.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663207  75 ERQRLAKERREEREkclAAREQQILEKQKRAKLQYEKQI------------EERWRKLEEQRQREDQKRAAVEEKRKQKL 142
Cdd:pfam17380 386 ERQQKNERVRQELE---AARKVKILEEERQRKIQQQKVEmeqiraeqeearQREVRRLEEERAREMERVRLEEQERQQQV 462

                          90       100
                  ....*....|....*....|....*.
gi 1318663207 143 REEEERLEAMMRRSLERTQQLELKKK 168
Cdd:pfam17380 463 ERLRQQEEERKRKKLELEKEKRDRKR 488
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
75-164 4.71e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 40.52  E-value: 4.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663207  75 ERQRLAKERREEREKCLAAREQQILEKQKRAKLQyekQIEERWRKLEEQRQREDQKRAAVEEKRKQKLREEEERLEAMMR 154
Cdd:COG4717   109 AELEELREELEKLEKLLQLLPLYQELEALEAELA---ELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQ 185

                          90
                  ....*....|
gi 1318663207 155 RSLERTQQLE 164
Cdd:COG4717   186 LSLATEEELQ 195
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 72-141 5.35e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 40.11  E-value: 5.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663207  72 KSDERQRLAKERREEREKCLAA---REQQIL------EKQKRAKLQYEKQIEERWRKLEEQR-----QREDQKRAAVEEK 137
Cdd:pfam17380 433 RQREVRRLEEERAREMERVRLEeqeRQQQVErlrqqeEERKRKKLELEKEKRDRKRAEEQRRkilekELEERKQAMIEEE 512


                  ....
gi 1318663207 138 RKQK 141
Cdd:pfam17380 513 RKRK 516
PTZ00121 PTZ00121
MAEBL; Provisional
 48-168 5.90e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.12  E-value: 5.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663207   48 KSAEAASGRASQStpRSAgmDGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRAKLQYEKQIEERWRKLEEQRQRE 127
Cdd:PTZ00121  1431 KKADEAKKKAEEA--KKA--DEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAA 1506

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1318663207  128 DQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKK 168
Cdd:PTZ00121  1507 EAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKK 1547
DDRGK pfam09756
DDRGK domain; This is a family of proteins of approximately 300 residues, found in plants and ...
 76-129 6.20e-03

DDRGK domain; This is a family of proteins of approximately 300 residues, found in plants and vertebrates. They contain a highly conserved DDRGK motif.


Pssm-ID: 370664 [Multi-domain]  Cd Length: 188  Bit Score: 38.48  E-value: 6.20e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1318663207  76 RQRLAKER-REEREKCLAAREQQILEKQKRAKLQYEKQIEERWRKLEEQRQREDQ 129
Cdd:pfam09756  19 QQREAEEEeREEREKLEEKREEEYKEREEREEEAEKEKEEEERKQEEEQERKEQE 73
PTZ00121 PTZ00121
MAEBL; Provisional
 78-167 7.05e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.12  E-value: 7.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663207   78 RLAKERREEREKCLAAREQQILEKQKRAKLQYEKQIEERWRKLEEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRSL 157
Cdd:PTZ00121  1662 KAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEE 1741

                           90
                   ....*....|
gi 1318663207  158 ERTQQLELKK 167
Cdd:PTZ00121  1742 DKKKAEEAKK 1751
PTZ00121 PTZ00121
MAEBL; Provisional
 72-164 8.21e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 39.74  E-value: 8.21e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663207   72 KSDERQRLAKERREEREKCLAAREQQILEK--QKRAKLQYEKQIEERWRKLEEQRQREDQKRAAVEEKRKQKLREEEERL 149
Cdd:PTZ00121  1559 KAEEKKKAEEAKKAEEDKNMALRKAEEAKKaeEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQL 1638

                           90
                   ....*....|....*
gi 1318663207  150 EAMMRRSLERTQQLE 164
Cdd:PTZ00121  1639 KKKEAEEKKKAEELK 1653
PTZ00121 PTZ00121
MAEBL; Provisional
 72-168 8.56e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 39.74  E-value: 8.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663207   72 KSDERQRLAKERREEREKCLAAREQQILEKQKRAKLQYEKQIEERWRKLEEQRQREDQKRAAVEEKRKQKLREEEERLEA 151
Cdd:PTZ00121  1290 KKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAA 1369

                           90
                   ....*....|....*..
gi 1318663207  152 MMRRSLERTQQLELKKK 168
Cdd:PTZ00121  1370 EKKKEEAKKKADAAKKK 1386
DUF4659 pfam15558
Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins ...
 76-173 8.69e-03

Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins in this family are typically between 427 and 674 amino acids in length. There are two completely conserved residues (D and I) that may be functionally important.


Pssm-ID: 464768 [Multi-domain]  Cd Length: 374  Bit Score: 39.25  E-value: 8.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663207  76 RQRLAKERREEREKcLAAREQQILEKQKRAKLQYEKQIEERWRKLEEQRQREDQKRAAVEEKRKQKLReeeerleamMRR 155
Cdd:pfam15558  68 EQRKARLGREERRR-ADRREKQVIEKESRWREQAEDQENQRQEKLERARQEAEQRKQCQEQRLKEKEE---------ELQ 137

                          90
                  ....*....|....*...
gi 1318663207 156 SLERTQQLELKKKCSWAG 173
Cdd:pfam15558 138 ALREQNSLQLQERLEEAC 155
PTZ00121 PTZ00121
MAEBL; Provisional
 48-168 9.64e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 39.74  E-value: 9.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1318663207   48 KSAEAASGRASQSTprsagmdgflKSDERQRLAKERREEREKCLAAREQQILEKQKRAKLQYEKQIEERWRKLEEQRQRE 127
Cdd:PTZ00121  1378 KKADAAKKKAEEKK----------KADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKAD 1447

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1318663207  128 DQKRAAvEEKRK----QKLREEEERLEAMMRRSLERTQQLELKKK 168
Cdd:PTZ00121  1448 EAKKKA-EEAKKaeeaKKKAEEAKKADEAKKKAEEAKKADEAKKK 1491
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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