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Conserved domains on  [gi|1285032881|ref|NP_001345507|]
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beta-1,4 N-acetylgalactosaminyltransferase 1 isoform 6 [Mus musculus]

Protein Classification

glycosyltransferase family 2 protein( domain architecture ID 10455355)

glycosyltransferase family 2 protein catalyzes the transfer of saccharide moieties from a donor to an acceptor to form glycosidic bonds

CATH:  3.90.550.10
CAZY:  GT2
EC:  2.4.-.-
Gene Ontology:  GO:0016757
PubMed:  12691742|9445404
SCOP:  3000077

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 283-429 3.40e-17

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


:

Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 78.98  E-value: 3.40e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285032881 283 TIATKTFLRYDRLRTLIASIRR-FYPTVTIVIADDSDKPE--------RISDPHVEHYFMPFGKGWFAGRNLAVSQVTTK 353
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNqTYPNFEIIVVDDGSTDGtveiaeeyAKKDPRVRVIRLPENRGKAGARNAGLRAATGD 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1285032881 354 YVLWVDDDFVFTaRTRLEKLVDVLEKTPLDLVGGAVREISGYATTYRQLLSVEPGAPGLGNCFRQKQGFHHELVGF 429
Cdd:pfam00535  81 YIAFLDADDEVP-PDWLEKLVEALEEDGADVVVGSRYVIFGETGEYRRASRITLSRLPFFLGLRLLGLNLPFLIGG 155
 
Name Accession Description Interval E-value
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 283-429 3.40e-17

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 78.98  E-value: 3.40e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285032881 283 TIATKTFLRYDRLRTLIASIRR-FYPTVTIVIADDSDKPE--------RISDPHVEHYFMPFGKGWFAGRNLAVSQVTTK 353
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNqTYPNFEIIVVDDGSTDGtveiaeeyAKKDPRVRVIRLPENRGKAGARNAGLRAATGD 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1285032881 354 YVLWVDDDFVFTaRTRLEKLVDVLEKTPLDLVGGAVREISGYATTYRQLLSVEPGAPGLGNCFRQKQGFHHELVGF 429
Cdd:pfam00535  81 YIAFLDADDEVP-PDWLEKLVEALEEDGADVVVGSRYVIFGETGEYRRASRITLSRLPFFLGLRLLGLNLPFLIGG 155
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 293-458 7.74e-11

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 61.64  E-value: 7.74e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285032881 293 DRLRTLIASIRRF-YPTVTIVIADD--SDKPERI------SDPHVEHYFMPFGKGWFAGRNLAVSQVTTKYVLWVDDDFV 363
Cdd:COG0463    15 EYLEEALESLLAQtYPDFEIIVVDDgsTDGTAEIlrelaaKDPRIRVIRLERNRGKGAARNAGLAAARGDYIAFLDADDQ 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285032881 364 FTARtRLEKLVDVLEKTPLDLVGGaVREISGYATTYRQLLSvepGAPGLGNCFRQkqgfhhelvgfpscvVTDGVVNFFL 443
Cdd:COG0463    95 LDPE-KLEELVAALEEGPADLVYG-SRLIREGESDLRRLGS---RLFNLVRLLTN---------------LPDSTSGFRL 154

                         170
                  ....*....|....*
gi 1285032881 444 ARTDKVRQVGFDPRL 458
Cdd:COG0463   155 FRREVLEELGFDEGF 169
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 291-434 1.01e-07

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 51.35  E-value: 1.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285032881 291 RYDRLRTLIASIRR-FYPTVTIVIADD--SDKPERI------SDPHVEHYFMPFGKGWFAGRNLAVSQVTTKYVLWVDDD 361
Cdd:cd00761     8 EEPYLERCLESLLAqTYPNFEVIVVDDgsTDGTLEIleeyakKDPRVIRVINEENQGLAAARNAGLKAARGEYILFLDAD 87

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1285032881 362 FVFtARTRLEKLVDVLEKTP-LDLVGGAvreiSGYATTYRQLLSVEPGAPGLGNCFRQKQGFHHELVGFPSCVV 434
Cdd:cd00761    88 DLL-LPDWLERLVAELLADPeADAVGGP----GNLLFRRELLEEIGGFDEALLSGEEDDDFLLRLLRGGKVAFR 156
glyco_TIGR04440 TIGR04440
glycosyltransferase domain; This model describes a putative glycotransferase domain, related ...
 282-381 1.39e-06

glycosyltransferase domain; This model describes a putative glycotransferase domain, related to the group 2 family glycosyltransferases of pfam00535.


Pssm-ID: 275233  Cd Length: 215  Bit Score: 49.22  E-value: 1.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285032881 282 VTIATKTFLRYDRLRTLIASIRRFYPTVTIVIADDSDKPER---------ISDPHVEHYFMPFGKGWFAGRNL-AVSQVT 351
Cdd:TIGR04440   2 LTIIIPTYNRPEYLKRWLRYYSDFGCDYRIIIADSSDEKFNennlkvfknYSNPNITYLHYPDLGVPFYEKLLdALEQVE 81

                          90       100       110
                  ....*....|....*....|....*....|
gi 1285032881 352 TKYVLWVDDDFVFTARTrLEKLVDVLEKTP 381
Cdd:TIGR04440  82 TPYVVICADDDFIIPSG-LTECLSFLEANP 110
 
Name Accession Description Interval E-value
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 283-429 3.40e-17

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 78.98  E-value: 3.40e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285032881 283 TIATKTFLRYDRLRTLIASIRR-FYPTVTIVIADDSDKPE--------RISDPHVEHYFMPFGKGWFAGRNLAVSQVTTK 353
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNqTYPNFEIIVVDDGSTDGtveiaeeyAKKDPRVRVIRLPENRGKAGARNAGLRAATGD 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1285032881 354 YVLWVDDDFVFTaRTRLEKLVDVLEKTPLDLVGGAVREISGYATTYRQLLSVEPGAPGLGNCFRQKQGFHHELVGF 429
Cdd:pfam00535  81 YIAFLDADDEVP-PDWLEKLVEALEEDGADVVVGSRYVIFGETGEYRRASRITLSRLPFFLGLRLLGLNLPFLIGG 155
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 293-458 7.74e-11

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 61.64  E-value: 7.74e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285032881 293 DRLRTLIASIRRF-YPTVTIVIADD--SDKPERI------SDPHVEHYFMPFGKGWFAGRNLAVSQVTTKYVLWVDDDFV 363
Cdd:COG0463    15 EYLEEALESLLAQtYPDFEIIVVDDgsTDGTAEIlrelaaKDPRIRVIRLERNRGKGAARNAGLAAARGDYIAFLDADDQ 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285032881 364 FTARtRLEKLVDVLEKTPLDLVGGaVREISGYATTYRQLLSvepGAPGLGNCFRQkqgfhhelvgfpscvVTDGVVNFFL 443
Cdd:COG0463    95 LDPE-KLEELVAALEEGPADLVYG-SRLIREGESDLRRLGS---RLFNLVRLLTN---------------LPDSTSGFRL 154

                         170
                  ....*....|....*
gi 1285032881 444 ARTDKVRQVGFDPRL 458
Cdd:COG0463   155 FRREVLEELGFDEGF 169
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
282-376 1.25e-08

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 55.00  E-value: 1.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285032881 282 VTIATKTFLRYDRLRTLIASIRRF-YPTVTIVIADDS------DKPERISDPHVEHYFMPFGKGWFAGRNLAVSQVTTKY 354
Cdd:COG1216     5 VSVVIPTYNRPELLRRCLESLLAQtYPPFEVIVVDNGstdgtaELLAALAFPRVRVIRNPENLGFAAARNLGLRAAGGDY 84

                          90       100
                  ....*....|....*....|..
gi 1285032881 355 VLWVDDDFVFTARTrLEKLVDV 376
Cdd:COG1216    85 LLFLDDDTVVEPDW-LERLLAA 105
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 291-434 1.01e-07

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 51.35  E-value: 1.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285032881 291 RYDRLRTLIASIRR-FYPTVTIVIADD--SDKPERI------SDPHVEHYFMPFGKGWFAGRNLAVSQVTTKYVLWVDDD 361
Cdd:cd00761     8 EEPYLERCLESLLAqTYPNFEVIVVDDgsTDGTLEIleeyakKDPRVIRVINEENQGLAAARNAGLKAARGEYILFLDAD 87

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1285032881 362 FVFtARTRLEKLVDVLEKTP-LDLVGGAvreiSGYATTYRQLLSVEPGAPGLGNCFRQKQGFHHELVGFPSCVV 434
Cdd:cd00761    88 DLL-LPDWLERLVAELLADPeADAVGGP----GNLLFRRELLEEIGGFDEALLSGEEDDDFLLRLLRGGKVAFR 156
glyco_TIGR04440 TIGR04440
glycosyltransferase domain; This model describes a putative glycotransferase domain, related ...
 282-381 1.39e-06

glycosyltransferase domain; This model describes a putative glycotransferase domain, related to the group 2 family glycosyltransferases of pfam00535.


Pssm-ID: 275233  Cd Length: 215  Bit Score: 49.22  E-value: 1.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285032881 282 VTIATKTFLRYDRLRTLIASIRRFYPTVTIVIADDSDKPER---------ISDPHVEHYFMPFGKGWFAGRNL-AVSQVT 351
Cdd:TIGR04440   2 LTIIIPTYNRPEYLKRWLRYYSDFGCDYRIIIADSSDEKFNennlkvfknYSNPNITYLHYPDLGVPFYEKLLdALEQVE 81

                          90       100       110
                  ....*....|....*....|....*....|
gi 1285032881 352 TKYVLWVDDDFVFTARTrLEKLVDVLEKTP 381
Cdd:TIGR04440  82 TPYVVICADDDFIIPSG-LTECLSFLEANP 110
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 293-397 5.62e-04

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 42.04  E-value: 5.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285032881 293 DRLRTLIASIRRF-YPT--VTIVIADDSDKPE--------RISDPHVEHYFMPF--GKGWfaGRNLAVSQVTTKYVLWVD 359
Cdd:COG1215    42 AVIEETLRSLLAQdYPKekLEVIVVDDGSTDEtaeiarelAAEYPRVRVIERPEngGKAA--ALNAGLKAARGDIVVFLD 119

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1285032881 360 DDFVFtARTRLEKLVDVLEKTPLDLVGG-------AVREISGYAT 397
Cdd:COG1215   120 ADTVL-DPDWLRRLVAAFADPGVGASGAnlafrreALEEVGGFDE 163
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 291-381 3.51e-03

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 38.31  E-value: 3.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1285032881 291 RYDRLRTLIASIRRF-YPTVTIVIAD-DSDK--PERISD--PHVEHYFMPFGKGWFAGRNLAVSQVTTKYVLWVDDDFVF 364
Cdd:cd04186     8 SLEYLKACLDSLLAQtYPDFEVIVVDnASTDgsVELLRElfPEVRLIRNGENLGFGAGNNQGIREAKGDYVLLLNPDTVV 87

                          90
                  ....*....|....*..
gi 1285032881 365 TARTrLEKLVDVLEKTP 381
Cdd:cd04186    88 EPGA-LLELLDAAEQDP 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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