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Conserved domains on  [gi|4503285|ref|NP_001345|]
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aldo-keto reductase family 1 member C2 isoform 1 [Homo sapiens]

Protein Classification

aldo/keto reductase family protein( domain architecture ID 14442631)

aldo/keto reductase (AKR) family protein is an oxidoreductase that may catalyze the reduction of aldehydes and/or ketones to their corresponding primary and/or secondary alcohols

CATH:  3.20.20.100
EC:  1.-.-.-
Gene Ontology:  GO:0016491
PubMed:  25304492|19706366|9307009|12663943|16970545

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AKR_AKR1C1-35 cd19108
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ...
 6-308 0e+00

AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.


:

Pssm-ID: 381334 [Multi-domain]  Cd Length: 303  Bit Score: 703.99  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285    6 QCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKL 85
Cdd:cd19108   1 QRVKLNDGHFIPVLGFGTYAPEEVPKSKALEATKLAIDAGFRHIDSAYLYQNEEEVGQAIRSKIADGTVKREDIFYTSKL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   86 WSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGV 165
Cdd:cd19108  81 WCTFHRPELVRPALEKSLKKLQLDYVDLYLIHFPVALKPGEELFPKDENGKLIFDTVDLCATWEAMEKCKDAGLAKSIGV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  166 SNFNHRLLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALA 245
Cdd:cd19108 161 SNFNRRQLEMILNKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAYSALGSQRDKEWVDQNSPVLLEDPVLCALA 240

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4503285  246 KKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTL 308
Cdd:cd19108 241 KKHKRTPALIALRYQLQRGVVVLAKSFNEKRIKENLQVFEFQLTSEDMKALDGLNRNLRYLPA 303
 
Name Accession Description Interval E-value
AKR_AKR1C1-35 cd19108
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ...
 6-308 0e+00

AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.


Pssm-ID: 381334 [Multi-domain]  Cd Length: 303  Bit Score: 703.99  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285    6 QCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKL 85
Cdd:cd19108   1 QRVKLNDGHFIPVLGFGTYAPEEVPKSKALEATKLAIDAGFRHIDSAYLYQNEEEVGQAIRSKIADGTVKREDIFYTSKL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   86 WSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGV 165
Cdd:cd19108  81 WCTFHRPELVRPALEKSLKKLQLDYVDLYLIHFPVALKPGEELFPKDENGKLIFDTVDLCATWEAMEKCKDAGLAKSIGV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  166 SNFNHRLLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALA 245
Cdd:cd19108 161 SNFNRRQLEMILNKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAYSALGSQRDKEWVDQNSPVLLEDPVLCALA 240

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4503285  246 KKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTL 308
Cdd:cd19108 241 KKHKRTPALIALRYQLQRGVVVLAKSFNEKRIKENLQVFEFQLTSEDMKALDGLNRNLRYLPA 303
ARA1 COG0656
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...
 12-305 9.62e-120

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440421 [Multi-domain]  Cd Length: 259  Bit Score: 344.73  E-value: 9.62e-120
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   12 DGHFMPVLGFGTYapaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRskiaDGSVKREDIFYTSKLWSNSHR 91
Cdd:COG0656   1 NGVEIPALGLGTW---QLPGEEAAAAVRTALEAGYRHIDTAAMYGNEEGVGEAIA----ASGVPREELFVTTKVWNDNHG 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   92 PELVRPALERSLKNLQLDYVDLYLIHFPVSVkpgeevipkdengkilfdtvDLCATWEAMEKCKDAGLAKSIGVSNFNHR 171
Cdd:COG0656  74 YDDTLAAFEESLERLGLDYLDLYLIHWPGPG--------------------PYVETWRALEELYEEGLIRAIGVSNFDPE 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  172 LLEMILNKPGlkYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHReepwvdpnspvLLEDPVLCALAKKHKRT 251
Cdd:COG0656 134 HLEELLAETG--VKPAVNQVELHPYLQQRELLAFCREHGIVVEAYSPLGRGK-----------LLDDPVLAEIAEKHGKT 200

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 4503285  252 PALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRY 305
Cdd:COG0656 201 PAQVVLRWHLQRGVVVIPKSVTPERIRENLDAFDFELSDEDMAAIDALDRGERL 254
Aldo_ket_red pfam00248
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...
 19-300 1.71e-70

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.


Pssm-ID: 425554 [Multi-domain]  Cd Length: 290  Bit Score: 220.65  E-value: 1.71e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285     19 LGFGTYA----PAEVPKSKALEAVKLAIEAGFHHIDSAHVYN---NEEQVGLAIrskiADGSVKREDIFYTSKL------ 85
Cdd:pfam00248   1 IGLGTWQlgggWGPISKEEALEALRAALEAGINFIDTAEVYGdgkSEELLGEAL----KDYPVKRDKVVIATKVpdgdgp 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285     86 WSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPvsvkpgeevipkdengkilFDTVDLCATWEAMEKCKDAGLAKSIGV 165
Cdd:pfam00248  77 WPSGGSKENIRKSLEESLKRLGTDYIDLYYLHWP-------------------DPDTPIEETWDALEELKKEGKIRAIGV 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285    166 SNFNHRLLEMILNKPglKYKPVCNQVECHPYF--NQRKLLDFCKSKDIVLVAYSALGS----------------HREEPW 227
Cdd:pfam00248 138 SNFDAEQIEKALTKG--KIPIVAVQVEYNLLRrrQEEELLEYCKKNGIPLIAYSPLGGglltgkytrdpdkgpgERRRLL 215

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4503285    228 VDPNSPVLLEDPVLCALAKKHKRTPALIALRY--QLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN 300
Cdd:pfam00248 216 KKGTPLNLEALEALEEIAKEHGVSPAQVALRWalSKPGVTIPIPGASNPEQLEDNLGALEFPLSDEEVARIDELL 290
dkgA PRK11565
2,5-didehydrogluconate reductase DkgA;
8-304 8.45e-66

2,5-didehydrogluconate reductase DkgA;


Pssm-ID: 183203 [Multi-domain]  Cd Length: 275  Bit Score: 208.00  E-value: 8.45e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285     8 VKLNDGHFMPVLGFGTYapaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSkiadGSVKREDIFYTSKLWS 87
Cdd:PRK11565   7 IKLQDGNVMPQLGLGVW---QASNEEVITAIHKALEVGYRSIDTAAIYKNEEGVGKALKE----ASVAREELFITTKLWN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285    88 NSHRPelVRPALERSLKNLQLDYVDLYLIHFPVsvkpgeeviPKDENgkilfdTVDlcaTWEAMEKCKDAGLAKSIGVSN 167
Cdd:PRK11565  80 DDHKR--PREALEESLKKLQLDYVDLYLMHWPV---------PAIDH------YVE---AWKGMIELQKEGLIKSIGVCN 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   168 FNHRLLEMILNKPGLKykPVCNQVECHPYFNQRKLLdfckskdivlvAYSALGSHREEPWvdpnSPV------LLEDPVL 241
Cdd:PRK11565 140 FQIHHLQRLIDETGVT--PVINQIELHPLMQQRQLH-----------AWNATHKIQTESW----SPLaqggkgVFDQKVI 202

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4503285   242 CALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVR 304
Cdd:PRK11565 203 RDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVFDFRLDKDELGEIAKLDQGKR 265
 
Name Accession Description Interval E-value
AKR_AKR1C1-35 cd19108
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ...
 6-308 0e+00

AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.


Pssm-ID: 381334 [Multi-domain]  Cd Length: 303  Bit Score: 703.99  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285    6 QCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKL 85
Cdd:cd19108   1 QRVKLNDGHFIPVLGFGTYAPEEVPKSKALEATKLAIDAGFRHIDSAYLYQNEEEVGQAIRSKIADGTVKREDIFYTSKL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   86 WSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGV 165
Cdd:cd19108  81 WCTFHRPELVRPALEKSLKKLQLDYVDLYLIHFPVALKPGEELFPKDENGKLIFDTVDLCATWEAMEKCKDAGLAKSIGV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  166 SNFNHRLLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALA 245
Cdd:cd19108 161 SNFNRRQLEMILNKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAYSALGSQRDKEWVDQNSPVLLEDPVLCALA 240

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4503285  246 KKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTL 308
Cdd:cd19108 241 KKHKRTPALIALRYQLQRGVVVLAKSFNEKRIKENLQVFEFQLTSEDMKALDGLNRNLRYLPA 303
AKR_AKR1D1-3 cd19109
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes ...
 13-319 7.51e-180

AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) from Homo sapiens (AKR1D1), Rattus norvegicus (liver, AKR1D2), and Oryctolagus cuniculus (AKR1D3). 3-oxo-5-beta-steroid 4-dehydrogenase, also called delta(4)-3-ketosteroid 5-beta-reductase (EC 1.3.99.6), or delta(4)-3-oxosteroid 5-beta-reductase, or 5-beta-reductase, efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites.


Pssm-ID: 381335 [Multi-domain]  Cd Length: 308  Bit Score: 498.94  E-value: 7.51e-180
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   13 GHFMPVLGFGTYA-PAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSNSHR 91
Cdd:cd19109   1 GNSIPIIGLGTYSePKTTPKGACAEAVKVAIDTGYRHIDGAYIYQNEHEVGQAIREKIAEGKVKREDIFYCGKLWNTCHP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   92 PELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHR 171
Cdd:cd19109  81 PELVRPTLERTLKVLQLDYVDLYIIEMPMAFKPGDEIYPRDENGKWLYHKTNLCATWEALEACKDAGLVKSIGVSNFNRR 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  172 LLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRT 251
Cdd:cd19109 161 QLELILNKPGLKHKPVSNQVECHPYFTQPKLLEFCQQHDIVIVAYSPLGTCRDPIWVNVSSPPLLEDPLLNSIGKKYNKT 240

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4503285  252 PALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPF 319
Cdd:cd19109 241 AAQVVLRFNIQRGVVVIPKSFNPERIKENFQIFDFSLTEEEMKDIEALNKNVRYVELLMWRDHPEYPF 308
AKR_AKR1A1-4 cd19106
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ...
 10-305 6.41e-139

AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.


Pssm-ID: 381332 [Multi-domain]  Cd Length: 305  Bit Score: 395.21  E-value: 6.41e-139
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   10 LNDGHFMPVLGFGTY--APAEVPkskalEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKI-ADGSVKREDIFYTSKLW 86
Cdd:cd19106   1 LHTGQKMPLIGLGTWksKPGQVK-----AAVKYALDAGYRHIDCAAVYGNEQEVGEALKEKVgPGKAVPREDLFVTSKLW 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   87 SNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVS 166
Cdd:cd19106  76 NTKHHPEDVEPALRKTLKDLQLDYLDLYLIHWPYAFERGDNPFPKNPDGTIRYDSTHYKETWKAMEKLVDKGLVKAIGLS 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  167 NFNHRLLEMILNKPglKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGShREEPWVDPNSPVLLEDPVLCALAK 246
Cdd:cd19106 156 NFNSRQIDDILSVA--RIKPAVLQVECHPYLAQNELIAHCKARGLVVTAYSPLGS-PDRPWAKPDEPVLLEEPKVKALAK 232

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 4503285  247 KHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRY 305
Cdd:cd19106 233 KYNKSPAQILLRWQVQRGVVVIPKSVTPSRIKQNIQVFDFTLSPEEMKQLDALNRNWRY 291
AKR_AKR1B1-19 cd19107
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ...
 16-323 4.04e-138

AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.


Pssm-ID: 381333 [Multi-domain]  Cd Length: 307  Bit Score: 393.32  E-value: 4.04e-138
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   16 MPVLGFGTYapaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELV 95
Cdd:cd19107   4 MPILGLGTW---KSPPGQVTEAVKVAIDAGYRHIDCAYVYQNENEVGEAIQEKIKEQVVKREDLFIVSKLWCTFHEKGLV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   96 RPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEM 175
Cdd:cd19107  81 KGACQKTLSDLKLDYLDLYLIHWPTGFKPGKELFPLDESGNVIPSDTTFLDTWEAMEELVDEGLVKAIGVSNFNHLQIER 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  176 ILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGShREEPWVDPNSPVLLEDPVLCALAKKHKRTPALI 255
Cdd:cd19107 161 ILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGS-PDRPWAKPEDPSLLEDPKIKEIAAKHNKTTAQV 239

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4503285  256 ALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPFSDEY 323
Cdd:cd19107 240 LIRFPIQRNLVVIPKSVTPERIAENFKVFDFELSSEDMATILSFNRNWRACALLSCSSHKDYPFHAEY 307
AKR_AKR2E1-5 cd19116
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ...
 7-305 1.79e-130

AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.


Pssm-ID: 381342 [Multi-domain]  Cd Length: 292  Bit Score: 373.54  E-value: 1.79e-130
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285    7 CVKLNDGHFMPVLGFGTYApaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLW 86
Cdd:cd19116   2 TIKLNDGNEIPAIALGTWK--LKDDEGVRQAVKHAIEAGYRHIDTAYLYGNEAEVGEAIREKIAEGVVKREDLFITTKLW 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   87 SNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKpgeEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVS 166
Cdd:cd19116  80 NSYHEREQVEPALRESLKRLGLDYVDLYLIHWPVAFK---ENNDSESNGDGSLSDIDYLETWRGMEDLVKLGLTRSIGVS 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  167 NFNHRLLEMILNkpGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPwvDPNSPVLLEDPVLCALAK 246
Cdd:cd19116 157 NFNSEQINRLLS--NCNIKPAVNQIEVHPTLTQEKLVAYCQSNGIVVMAYSPFGRLVPRG--QTNPPPRLDDPTLVAIAK 232

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 4503285  247 KHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRY 305
Cdd:cd19116 233 KYGKTTAQIVLRYLIDRGVVPIPKSSNKKRIKENIDIFDFQLTPEEVAALNSFNTNQRV 291
AKR_AKR1-5-like cd19071
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ...
 16-297 2.80e-125

AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.


Pssm-ID: 381297 [Multi-domain]  Cd Length: 251  Bit Score: 358.72  E-value: 2.80e-125
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   16 MPVLGFGTYapaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIadgsVKREDIFYTSKLWSNSHRPELV 95
Cdd:cd19071   1 MPLIGLGTY---KLKPEETAEAVLAALEAGYRHIDTAAAYGNEAEVGEAIRESG----VPREELFITTKLWPTDHGYERV 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   96 RPALERSLKNLQLDYVDLYLIHFPVSVKPGEevipkdengkilfDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEM 175
Cdd:cd19071  74 REALEESLKDLGLDYLDLYLIHWPVPGKEGG-------------SKEARLETWRALEELVDEGLVRSIGVSNFNVEHLEE 140

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  176 ILNKPglKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREepwvdpnspVLLEDPVLCALAKKHKRTPALI 255
Cdd:cd19071 141 LLAAA--RIKPAVNQIELHPYLQQKELVEFCKEHGIVVQAYSPLGRGRR---------PLLDDPVLKEIAKKYGKTPAQV 209

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 4503285  256 ALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAID 297
Cdd:cd19071 210 LLRWALQRGVVVIPKSSNPERIKENLDVFDFELSEEDMAAID 251
AKR_AKR1E1-2 cd19110
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ...
 16-323 2.43e-120

AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.


Pssm-ID: 381336 [Multi-domain]  Cd Length: 301  Bit Score: 348.10  E-value: 2.43e-120
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   16 MPVLGFGTY--APAEVPkskalEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSNSHRPE 93
Cdd:cd19110   4 IPAVGLGTWkaSPGEVT-----EAVKVAIDAGYRHFDCAYLYHNESEVGAGIREKIKEGVVRREDLFIVSKLWCTCHKKS 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   94 LVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLL 173
Cdd:cd19110  79 LVKTACTRSLKALKLNYLDLYLIHWPMGFKPGEPDLPLDRSGMVIPSDTDFLDTWEAMEDLVIEGLVKNIGVSNFNHEQL 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  174 EMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEpwVDpnspvLLEDPVLCALAKKHKRTPA 253
Cdd:cd19110 159 ERLLNKPGLRVKPVTNQIECHPYLTQKKLISFCQSRNVSVTAYRPLGGSCEG--VD-----LIDDPVIQRIAKKHGKSPA 231

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  254 LIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPFSDEY 323
Cdd:cd19110 232 QILIRFQIQRNVIVIPKSVTPSRIKENIQVFDFELTEHDMDNLLSLDRNLRLATFPITENHKDYPFHIEY 301
ARA1 COG0656
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...
 12-305 9.62e-120

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440421 [Multi-domain]  Cd Length: 259  Bit Score: 344.73  E-value: 9.62e-120
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   12 DGHFMPVLGFGTYapaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRskiaDGSVKREDIFYTSKLWSNSHR 91
Cdd:COG0656   1 NGVEIPALGLGTW---QLPGEEAAAAVRTALEAGYRHIDTAAMYGNEEGVGEAIA----ASGVPREELFVTTKVWNDNHG 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   92 PELVRPALERSLKNLQLDYVDLYLIHFPVSVkpgeevipkdengkilfdtvDLCATWEAMEKCKDAGLAKSIGVSNFNHR 171
Cdd:COG0656  74 YDDTLAAFEESLERLGLDYLDLYLIHWPGPG--------------------PYVETWRALEELYEEGLIRAIGVSNFDPE 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  172 LLEMILNKPGlkYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHReepwvdpnspvLLEDPVLCALAKKHKRT 251
Cdd:COG0656 134 HLEELLAETG--VKPAVNQVELHPYLQQRELLAFCREHGIVVEAYSPLGRGK-----------LLDDPVLAEIAEKHGKT 200

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 4503285  252 PALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRY 305
Cdd:COG0656 201 PAQVVLRWHLQRGVVVIPKSVTPERIRENLDAFDFELSDEDMAAIDALDRGERL 254
AKR_AKR3G1 cd19123
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ...
 8-306 1.00e-117

AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.


Pssm-ID: 381349 [Multi-domain]  Cd Length: 297  Bit Score: 341.31  E-value: 1.00e-117
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285    8 VKLNDGHFMPVLGFGTYAPAevpKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWS 87
Cdd:cd19123   4 LPLSNGDLIPALGLGTWKSK---PGEVGQAVKQALEAGYRHIDCAAIYGNEAEIGAALAEVFKEGKVKREDLWITSKLWN 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   88 NSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGeEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSN 167
Cdd:cd19123  81 NSHAPEDVLPALEKTLADLQLDYLDLYLMHWPVALKKG-VGFPESGEDLLSLSPIPLEDTWRAMEELVDKGLCRHIGVSN 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  168 FNHRLLEMILNKPglKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGS-HREEPWVDPNSPVLLEDPVLCALAK 246
Cdd:cd19123 160 FSVKKLEDLLATA--RIKPAVNQVELHPYLQQPELLAFCRDNGIHLTAYSPLGSgDRPAAMKAEGEPVLLEDPVINKIAE 237

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  247 KHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYL 306
Cdd:cd19123 238 KHGASPAQVLIAWAIQRGTVVIPKSVNPERIQQNLEAAEVELDASDMATIAALDRHHRYV 297
AKR_AKR1G1_CeAKR cd19154
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ...
 7-304 3.56e-115

Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381380 [Multi-domain]  Cd Length: 303  Bit Score: 335.15  E-value: 3.56e-115
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285    7 CVKLNDGHFMPVLGFGTY--APAEVpkskaLEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSK 84
Cdd:cd19154   3 SITLSNGVKMPLIGLGTWqsKGAEG-----ITAVRTALKAGYRLIDTAFLYQNEEAIGEALAELLEEGVVKREDLFITTK 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   85 LWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIG 164
Cdd:cd19154  78 LWTHEHAPEDVEEALRESLKKLQLEYVDLYLIHAPAAFKDDEGESGTMENGMSIHDAVDVEDVWRGMEKVYDEGLTKAIG 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  165 VSNFNHRLLEMILNKPglKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGS-----HREEPWVDPnSPVLLEDP 239
Cdd:cd19154 158 VSNFNNDQIQRILDNA--RVKPHNNQVECHLYFPQKELVEFCKKHNISVTSYATLGSpgranFTKSTGVSP-APNLLQDP 234

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4503285  240 VLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVR 304
Cdd:cd19154 235 IVKAIAEKHGKTPAQVLLRYLLQRGIAVIPKSATPSRIKENFNIFDFSLSEEDMATLEEIEKSLR 299
AKR_AKR4C1-15 cd19125
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ...
 6-299 2.36e-111

AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.


Pssm-ID: 381351 [Multi-domain]  Cd Length: 287  Bit Score: 324.68  E-value: 2.36e-111
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285    6 QCVKLNDGHFMPVLGFGTYapaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKL 85
Cdd:cd19125   1 RFFKLNTGAKIPAVGLGTW---QADPGVVGNAVKTAIKEGYRHIDCAAIYGNEKEIGKALKKLFEDGVVKREDLFITSKL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   86 WSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEeviPKDENGKILfdTVDLCATWEAMEKCKDAGLAKSIGV 165
Cdd:cd19125  78 WCTDHAPEDVPPALEKTLKDLQLDYLDLYLIHWPVRLKKGA---HMPEPEEVL--PPDIPSTWKAMEKLVDSGKVRAIGV 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  166 SNFNHRLLEMILNKPglKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGShREEPWVDPNspvLLEDPVLCALA 245
Cdd:cd19125 153 SNFSVKKLEDLLAVA--RVPPAVNQVECHPGWQQDKLHEFCKSKGIHLSAYSPLGS-PGTTWVKKN---VLKDPIVTKVA 226

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 4503285  246 KKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGL 299
Cdd:cd19125 227 EKLGKTPAQVALRWGLQRGTSVLPKSTNEERIKENIDVFDWSIPEEDFAKFSSI 280
AKR_AKR4A_4B cd19124
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ...
 12-299 3.39e-105

AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.


Pssm-ID: 381350 [Multi-domain]  Cd Length: 281  Bit Score: 308.81  E-value: 3.39e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   12 DGHFMPVLGFGTYAPAEVPKsKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVK-REDIFYTSKLWSNSH 90
Cdd:cd19124   1 SGQTMPVIGMGTASDPPSPE-DIKAAVLEAIEVGYRHFDTAAAYGTEEALGEALAEALRLGLVKsRDELFVTSKLWCSDA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   91 RPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENgkiLFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNH 170
Cdd:cd19124  80 HPDLVLPALKKSLRNLQLEYVDLYLIHWPVSLKPGKFSFPIEEE---DFLPFDIKGVWEAMEECQRLGLTKAIGVSNFSC 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  171 RLLEMILNKPglKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHReEPWvdpNSPVLLEDPVLCALAKKHKR 250
Cdd:cd19124 157 KKLQELLSFA--TIPPAVNQVEMNPAWQQKKLREFCKANGIHVTAYSPLGAPG-TKW---GSNAVMESDVLKEIAAAKGK 230

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 4503285  251 TPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGL 299
Cdd:cd19124 231 TVAQVSLRWVYEQGVSLVVKSFNKERMKQNLDIFDWELTEEDLEKISEI 279
AKR_AKR1I_CgAKR1 cd19155
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ...
 7-304 5.46e-100

Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.


Pssm-ID: 381381 [Multi-domain]  Cd Length: 307  Bit Score: 296.74  E-value: 5.46e-100
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285    7 CVKLNDGHFMPVLGFGTYapaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLW 86
Cdd:cd19155   3 CVTFNNGEKMPVVGLGTW---QSSPEEIETAVDTALEAGYRHIDTAYVYRNEAAIGNVLKKWIDSGKVKREELFIVTKLP 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   87 SNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV-SVKPGEEVIPKDENGKILFD-TVDLCATWEAMEKCKDAGLAKSIG 164
Cdd:cd19155  80 PGGNRREKVEKFLLKSLEKLQLDYVDLYLIHFPVgSLSKEDDSGKLDPTGEHKQDyTTDLLDIWKAMEAQVDQGLTRSIG 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  165 VSNFNHRLLEMILNKPglKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGS----HREEPWVDP--NSPVLLED 238
Cdd:cd19155 160 LSNFNREQMARILKNA--RIKPANLQVELHVYLQQKDLVDFCSTHSITVTAYAPLGSpgaaHFSPGTGSPsgSSPDLLQD 237

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4503285  239 PVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVR 304
Cdd:cd19155 238 PVVKAIAERHGKSPAQVLLRWLMQRGVVVIPKSTNAARIKENFQVFDFELTEADMAKLSSLDKNIR 303
AKR_AKR1G1_1I cd19111
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ...
 13-305 1.07e-98

Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.


Pssm-ID: 381337 [Multi-domain]  Cd Length: 286  Bit Score: 292.48  E-value: 1.07e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   13 GHFMPVLGFGTY--APAEVpkskaLEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSNSH 90
Cdd:cd19111   1 GFPMPVIGLGTYqsPPEEV-----RAAVDYALFVGYRHIDTALSYQNEKAIGEALKWWLKNGKLKREEVFITTKLPPVYL 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   91 RPELVRPALERSLKNLQLDYVDLYLIHFPVSVkpgeeVIPKDENGKILFDTvDLCATWEAMEKCKDAGLAKSIGVSNFNH 170
Cdd:cd19111  76 EFKDTEKSLEKSLENLKLPYVDLYLIHHPCGF-----VNKKDKGERELASS-DVTSVWRAMEALVSEGKVKSIGLSNFNP 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  171 RLLEMILNKPglKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGS-HREEPWVDPNSPVLLEDPVLCALAKKHK 249
Cdd:cd19111 150 RQINKILAYA--KVKPSNLQLECHAYLQQRELRKFCNKKNIVVTAYAPLGSpGRANQSLWPDQPDLLEDPTVLAIAKELD 227

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 4503285  250 RTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRY 305
Cdd:cd19111 228 KTPAQVLLRFVLQRGTGVLPKSTNKERIEENFEVFDFELTEEHFKKLKTLDRNMKY 283
AKR_AKR3B1-3 cd19118
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ...
 10-299 6.07e-98

AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.


Pssm-ID: 381344 [Multi-domain]  Cd Length: 283  Bit Score: 290.47  E-value: 6.07e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   10 LNDGHFMPVLGFGTY--APAEVPKskaleAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIAD-GSVKREDIFYTSKLW 86
Cdd:cd19118   1 LNTGNKIPAIGLGTWqaEPGEVGA-----AVKIALKAGYRHLDLAKVYQNQHEVGQALKELLKEePGVKREDLFITSKLW 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   87 SNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPK----DENGKILFDT-VDLCATWEAMEKCKDAGLAK 161
Cdd:cd19118  76 NNSHRPEYVEPALDDTLKELGLDYLDLYLIHWPVAFKPTGDLNPLtavpTNGGEVDLDLsVSLVDTWKAMVELKKTGKVK 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  162 SIGVSNFNHRLLEMILNKPGLkyKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREepwvdpNSPVLLEDPVL 241
Cdd:cd19118 156 SIGVSNFSIDHLQAIIEETGV--VPAVNQIEAHPLLLQDELVDYCKSKNIHITAYSPLGNNLA------GLPLLVQHPEV 227

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 4503285  242 CALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEfqLTSEEMKAIDGL 299
Cdd:cd19118 228 KAIAAKLGKTPAQVLIAWGIQRGHSVIPKSVTPSRIRSNFEQVE--LSDDEFNAVTAL 283
AKR_BaDH-like cd19129
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ...
 11-305 4.62e-93

Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.


Pssm-ID: 381355 [Multi-domain]  Cd Length: 295  Bit Score: 278.57  E-value: 4.62e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   11 NDGHFMPVLGFGTYAPaevPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSNSH 90
Cdd:cd19129   1 NGSGAIPALGFGTLIP---DPSATRNAVKAALEAGFRHFDCAERYRNEAEVGEAMQEVFKAGKIRREDLFVTTKLWNTNH 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   91 RPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDT-VDLCATWEAMEKCKDAGLAKSIGVSNFN 169
Cdd:cd19129  78 RPERVKPAFEASLKRLQLDYLDLYLIHTPFAFQPGDEQDPRDANGNVIYDDgVTLLDTWRAMERLVDEGRCKAIGLSDVS 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  170 HRLLEMILNKPglKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGsHREEpwvdpnsPVLLEDPVLCALAKKHK 249
Cdd:cd19129 158 LEKLREIFEAA--RIKPAVVQVESHPYLPEWELLDFCKNHGIVLQAFAPLG-HGME-------PKLLEDPVITAIARRVN 227

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 4503285  250 RTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVfeFQLTSEEMKAI-DGLNRNVRY 305
Cdd:cd19129 228 KTPAQVLLAWAIQRGTALLTTSKTPSRIRENFDI--STLPEDAMREInEGIKTRYRF 282
AKR_AKR3F2_3 cd19073
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ...
 16-297 1.84e-92

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381299 [Multi-domain]  Cd Length: 243  Bit Score: 274.92  E-value: 1.84e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   16 MPVLGFGTYapaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIrskiADGSVKREDIFYTSKLWSNSHRPELV 95
Cdd:cd19073   1 IPALGLGTW---QLRGDDCANAVKEALELGYRHIDTAEIYNNEAEVGEAI----AESGVPREDLFITTKVWRDHLRPEDL 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   96 RPALERSLKNLQLDYVDLYLIHFPVSVKPGEEvipkdengkilfdtvdlcaTWEAMEKCKDAGLAKSIGVSNFNHRLLEM 175
Cdd:cd19073  74 KKSVDRSLEKLGTDYVDLLLIHWPNPTVPLEE-------------------TLGALKELKEAGKVKSIGVSNFTIELLEE 134

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  176 ILNKPGLkyKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGsHREepwvdpnspvLLEDPVLCALAKKHKRTPALI 255
Cdd:cd19073 135 ALDISPL--PIAVNQVEFHPFLYQAELLEYCRENDIVITAYSPLA-RGE----------VLRDPVIQEIAEKYDKTPAQV 201

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 4503285  256 ALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAID 297
Cdd:cd19073 202 ALRWLVQKGIVVIPKASSEDHLKENLAIFDWELTSEDVAKID 243
AKR_AKR5C2 cd19131
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ...
 8-300 6.76e-92

Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.


Pssm-ID: 381357 [Multi-domain]  Cd Length: 256  Bit Score: 274.25  E-value: 6.76e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285    8 VKLNDGHFMPVLGFGTYapaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRskiaDGSVKREDIFYTSKLWS 87
Cdd:cd19131   2 ITLNDGNTIPQLGLGVW---QVSNDEAASAVREALEVGYRSIDTAAIYGNEEGVGKAIR----ASGVPREELFITTKLWN 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   88 NSHRPELVRPALERSLKNLQLDYVDLYLIHFPVsvkPGEevipkdenGKIlfdtVDlcaTWEAMEKCKDAGLAKSIGVSN 167
Cdd:cd19131  75 SDQGYDSTLRAFDESLRKLGLDYVDLYLIHWPV---PAQ--------DKY----VE---TWKALIELKKEGRVKSIGVSN 136

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  168 FNHRLLEMILNKPGLKykPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHReepwvdpnspvLLEDPVLCALAKK 247
Cdd:cd19131 137 FTIEHLQRLIDETGVV--PVVNQIELHPRFQQRELRAFHAKHGIQTESWSPLGQGG-----------LLSDPVIGEIAEK 203

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 4503285  248 HKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN 300
Cdd:cd19131 204 HGKTPAQVVIRWHLQNGLVVIPKSVTPSRIAENFDVFDFELDADDMQAIAGLD 256
AKR_AKR2A1-2 cd19112
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ...
 8-305 1.66e-91

AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.


Pssm-ID: 381338 [Multi-domain]  Cd Length: 308  Bit Score: 275.13  E-value: 1.66e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285    8 VKLNDGHFMPVLGFGTYapaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWS 87
Cdd:cd19112   3 ITLNSGHKMPVIGLGVW---RMEPGEIKELILNAIKIGYRHFDCAADYKNEKEVGEALAEAFKTGLVKREDLFITTKLWN 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   88 NSHrpELVRPALERSLKNLQLDYVDLYLIHFPVSVKP---GEEVIPKDENGKILFD-TVDLCATWEAMEKCKDAGLAKSI 163
Cdd:cd19112  80 SDH--GHVIEACKDSLKKLQLDYLDLYLVHFPVATKHtgvGTTGSALGEDGVLDIDvTISLETTWHAMEKLVSAGLVRSI 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  164 GVSNFNHRLLEMILNKPglKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALG-SHREEPWVDPNSPvlLEDPVLC 242
Cdd:cd19112 158 GISNYDIFLTRDCLAYS--KIKPAVNQIETHPYFQRDSLVKFCQKHGISVTAHTPLGgAAANAEWFGSVSP--LDDPVLK 233

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4503285  243 ALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRY 305
Cdd:cd19112 234 DLAKKYGKSAAQIVLRWGIQRNTAVIPKSSKPERLKENIDVFDFQLSKEDMKLIKSLDRKYRT 296
AKR_AKR2D1 cd19115
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose ...
 8-317 3.32e-91

AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose reductase xyl1 (XR, EC 1.1.1.307) is a founding member of aldo-keto reductase family 2 member D1 (AKR2D1). It catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol in a NAD(P)H dependent manner.


Pssm-ID: 381341 [Multi-domain]  Cd Length: 311  Bit Score: 274.30  E-value: 3.32e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285    8 VKLNDGHFMPVLGFGTYapaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWS 87
Cdd:cd19115   5 VKLNSGYDMPLVGFGLW---KVNNDTCADQVYNAIKAGYRLFDGACDYGNEVEAGQGVARAIKEGIVKREDLFIVSKLWN 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   88 NSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK---PGEEVIP--KDENGKILFDTVDLCATWEAMEKCKDAGLAKS 162
Cdd:cd19115  82 TFHDGERVEPICRKQLADWGIDYFDLFLIHFPIALKyvdPAVRYPPgwFYDGKKVEFSNAPIQETWTAMEKLVDKGLARS 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  163 IGVSNFNHRLLeMILnkpgLKY---KPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALG--SHREEPWVDP-NSPVLL 236
Cdd:cd19115 162 IGVSNFSAQLL-MDL----LRYariRPATLQIEHHPYLTQPRLVKYAQKEGIAVTAYSSFGpqSFLELDLPGAkDTPPLF 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  237 EDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRyltldiFAGPPN 316
Cdd:cd19115 237 EHDVIKSIAEKHGKTPAQVLLRWATQRGIAVIPKSNNPKRLAQNLDVTGFDLEAEEIKAISALDIGLR------FNNPLN 310


                .
gi 4503285  317 Y 317
Cdd:cd19115 311 Y 311
AKR_AKR3C2-3 cd19120
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ...
 13-297 3.37e-91

Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.


Pssm-ID: 381346 [Multi-domain]  Cd Length: 269  Bit Score: 272.95  E-value: 3.37e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   13 GHFMPVLGFGT----YAPAEVPKSKAL-EAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRskiaDGSVKREDIFYTSKLWS 87
Cdd:cd19120   1 GSKIPAIAFGTgtawYKSGDDDIQRDLvDSVKLALKAGFRHIDTAEMYGNEKEVGEALK----ESGVPREDLFITTKVSP 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   88 NSHRPelvRPALERSLKNLQLDYVDLYLIHFPVSVKPGeevipkdengkilfdTVDLCATWEAMEKCKDAGLAKSIGVSN 167
Cdd:cd19120  77 GIKDP---REALRKSLAKLGVDYVDLYLIHSPFFAKEG---------------GPTLAEAWAELEALKDAGLVRSIGVSN 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  168 FNHRLLEMILNKPglKYKPVCNQVECHPYFN--QRKLLDFCKSKDIVLVAYSALGSHreepWVDPNSPVlleDPVLCALA 245
Cdd:cd19120 139 FRIEDLEELLDTA--KIKPAVNQIEFHPYLYpqQPALLEYCREHGIVVSAYSPLSPL----TRDAGGPL---DPVLEKIA 209

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 4503285  246 KKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAID 297
Cdd:cd19120 210 EKYGVTPAQVLLRWALQKGIVVVTTSSKEERMKEYLEAFDFELTEEEVEEID 261
AKR_AKR3A1-2 cd19117
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ...
 9-301 2.76e-90

AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.


Pssm-ID: 381343 [Multi-domain]  Cd Length: 284  Bit Score: 270.91  E-value: 2.76e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285    9 KLNDGHFMPVLGFGTY--APAEVPKskaleAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRskiaDGSVKREDIFYTSKLW 86
Cdd:cd19117   7 KLNTGAEIPAVGLGTWqsKPNEVAK-----AVEAALKAGYRHIDTAAIYGNEEEVGQGIK----DSGVPREEIFITTKLW 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   87 SNSHRPelVRPALERSLKNLQLDYVDLYLIHFPVSVKP-GEEVIPKDENG-KILFDTVDLCATWEAMEKCKDAGLAKSIG 164
Cdd:cd19117  78 CTWHRR--VEEALDQSLKKLGLDYVDLYLMHWPVPLDPdGNDFLFKKDDGtKDHEPDWDFIKTWELMQKLPATGKVKAIG 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  165 VSNFNHRLLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGShreepwvdPNSPvLLEDPVLCAL 244
Cdd:cd19117 156 VSNFSIKNLEKLLASPSAKIVPAVNQIELHPLLPQPKLVDFCKSKGIHATAYSPLGS--------TNAP-LLKEPVIIKI 226

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 4503285  245 AKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEfqLTSEEMKAIDGLNR 301
Cdd:cd19117 227 AKKHGKTPAQVIISWGLQRGYSVLPKSVTPSRIESNFKLFT--LSDEEFKEIDELHK 281
AKR_AKR2B1-10 cd19113
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ...
 8-305 2.93e-90

AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.


Pssm-ID: 381339 [Multi-domain]  Cd Length: 310  Bit Score: 272.01  E-value: 2.93e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285    8 VKLNDGHFMPVLGFGTYapaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWS 87
Cdd:cd19113   3 IKLNSGYKMPSVGFGCW---KLDNATAADQIYQAIKAGYRLFDGAEDYGNEKEVGEGVNRAIDEGLVKREELFLTSKLWN 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   88 NSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK--PGEEVIPK-----DENgKILFDTVDLCATWEAMEKCKDAGLA 160
Cdd:cd19113  80 NFHDPKNVETALNKTLSDLKLDYVDLFLIHFPIAFKfvPIEEKYPPgfycgDGD-NFVYEDVPILDTWKALEKLVDAGKI 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  161 KSIGVSNFNHRLLEMILNkpGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHR----EEPWVdPNSPVLL 236
Cdd:cd19113 159 KSIGVSNFPGALILDLLR--GATIKPAVLQIEHHPYLQQPKLIEYAQKAGITITAYSSFGPQSfvelNQGRA-LNTPTLF 235

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4503285  237 EDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRY 305
Cdd:cd19113 236 EHDTIKSIAAKHNKTPAQVLLRWATQRGIAVIPKSNLPERLLQNLSVNDFDLTKEDFEEIAKLDIGLRF 304
AKR_AKR5A_5G cd19126
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ...
 8-300 3.31e-89

AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381352 [Multi-domain]  Cd Length: 254  Bit Score: 267.38  E-value: 3.31e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285    8 VKLNDGHFMPVLGFGTYapaEVPK-SKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSkiadGSVKREDIFYTSKLW 86
Cdd:cd19126   1 VTLNNGTRMPWLGLGVF---QTPDgDETERAVQTALENGYRSIDTAAIYKNEEGVGEAIRE----SGVPREELFVTTKLW 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   87 SNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSvkpgeevipkdenGKILfdtvdlcATWEAMEKCKDAGLAKSIGVS 166
Cdd:cd19126  74 NDDQRARRTEDAFQESLDRLGLDYVDLYLIHWPGK-------------DKFI-------DTWKALEKLYASGKVKAIGVS 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  167 NFNHRLLEMILNKPglKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHReepwvdpnspvLLEDPVLCALAK 246
Cdd:cd19126 134 NFQEHHLEELLAHA--DVVPAVNQVEFHPYLTQKELRGYCKSKGIVVEAWSPLGQGG-----------LLSNPVLAAIGE 200

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 4503285  247 KHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN 300
Cdd:cd19126 201 KYGKSAAQVVLRWDIQHGVVTIPKSVHASRIKENADIFDFELSEDDMTAIDALN 254
AKR_AKR5G1-3 cd19157
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ...
 7-305 6.45e-89

AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381383 [Multi-domain]  Cd Length: 265  Bit Score: 266.95  E-value: 6.45e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285    7 CVKLNDGHFMPVLGFGTYapaEVPK-SKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRskiaDGSVKREDIFYTSKL 85
Cdd:cd19157   1 TVTLNNGVKMPWLGLGVF---KVEEgSEVVNAVKTALKNGYRSIDTAAIYGNEEGVGKGIK----ESGIPREELFITSKV 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   86 WSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEevipkdengkilfdtvdlcaTWEAMEKCKDAGLAKSIGV 165
Cdd:cd19157  74 WNADQGYDSTLKAFEASLERLGLDYLDLYLIHWPVKGKYKE--------------------TWKALEKLYKDGRVRAIGV 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  166 SNFNHRLLEMILNKPglKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHReepwvdpnspvLLEDPVLCALA 245
Cdd:cd19157 134 SNFQVHHLEDLLADA--EIVPMVNQVEFHPRLTQKELRDYCKKQGIQLEAWSPLMQGQ-----------LLDNPVLKEIA 200

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  246 KKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRY 305
Cdd:cd19157 201 EKYNKSVAQVILRWDLQNGVVTIPKSIKEHRIIENADVFDFELSQEDMDKIDALNENLRV 260
AKR_AKR5F1 cd19133
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ...
 8-300 1.16e-88

the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381359 [Multi-domain]  Cd Length: 255  Bit Score: 265.98  E-value: 1.16e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285    8 VKLNDGHFMPVLGFGTYapaEVP-KSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRskiaDGSVKREDIFYTSKLW 86
Cdd:cd19133   1 VTLNNGVEMPILGFGVF---QIPdPEECERAVLEAIKAGYRLIDTAAAYGNEEAVGRAIK----KSGIPREELFITTKLW 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   87 SNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSvkpgeevipkdengkilfdtvDLCATWEAMEKCKDAGLAKSIGVS 166
Cdd:cd19133  74 IQDAGYEKAKKAFERSLKRLGLDYLDLYLIHQPFG---------------------DVYGAWRAMEELYKEGKIRAIGVS 132

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  167 NFN-HRLLEMILNKpglKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEpwvdpnspvLLEDPVLCALA 245
Cdd:cd19133 133 NFYpDRLVDLILHN---EVKPAVNQIETHPFNQQIEAVEFLKKYGVQIEAWGPFAEGRNN---------LFENPVLTEIA 200

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 4503285  246 KKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN 300
Cdd:cd19133 201 EKYGKSVAQVILRWLIQRGIVVIPKSVRPERIAENFDIFDFELSDEDMEAIAALD 255
AKR_DrGR-like cd19136
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ...
 16-299 7.48e-88

Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).


Pssm-ID: 381362 [Multi-domain]  Cd Length: 262  Bit Score: 264.11  E-value: 7.48e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   16 MPVLGFGTY---APAEVpkSKALEAvklAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSNSHRP 92
Cdd:cd19136   1 MPILGLGTFrlrGEEEV--RQAVDA---ALKAGYRLIDTASVYRNEADIGKALRDLLPKYGLSREDIFITSKLAPKDQGY 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   93 ELVRPALERSLKNLQLDYVDLYLIHFP-VSVKPgeeviPKDENGKILfdtvdLCATWEAMEKCKDAGLAKSIGVSNFNHR 171
Cdd:cd19136  76 EKARAACLGSLERLGTDYLDLYLIHWPgVQGLK-----PSDPRNAEL-----RRESWRALEDLYKEGKLRAIGVSNYTVR 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  172 LLEMILNKPglKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGShreepwvdpNSPVLLEDPVLCALAKKHKRT 251
Cdd:cd19136 146 HLEELLKYC--EVPPAVNQVEFHPHLVQKELLKFCKDHGIHLQAYSSLGS---------GDLRLLEDPTVLAIAKKYGRT 214

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 4503285  252 PALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGL 299
Cdd:cd19136 215 PAQVLLRWALQQGIGVIPKSTNPERIAENIKVFDFELSEEDMAELNAL 262
AKR_GlAR-like cd19128
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ...
 17-299 4.57e-87

Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.


Pssm-ID: 381354 [Multi-domain]  Cd Length: 277  Bit Score: 262.46  E-value: 4.57e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   17 PVLGFGTYapaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVR 96
Cdd:cd19128   2 PRLGFGTY---KITESESKEAVKNAIKAGYRHIDCAYYYGNEAFIGIAFSEIFKDGGVKREDLFITSKLWPTMHQPENVK 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   97 PALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMI 176
Cdd:cd19128  79 EQLLITLQDLQLEYLDLFLIHWPLAFDMDTDGDPRDDNQIQSLSKKPLEDTWRAMEQCVDEKLTKNIGVSNYSTKLLTDL 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  177 LNKpgLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPwvdpnSPVLLEDPVLCALAKKHKRTPALIA 256
Cdd:cd19128 159 LNY--CKIKPFMNQIECHPYFQNDKLIKFCIENNIHVTAYRPLGGSYGDG-----NLTFLNDSELKALATKYNTTPPQVI 231

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 4503285  257 LRYQLQR---GVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGL 299
Cdd:cd19128 232 IAWHLQKwpkNYSVIPKSANKSRCQQNFDINDLALTKEDMDAINTL 277
AKR_AKR5D1_E1 cd19132
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ...
 10-301 3.58e-86

AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381358 [Multi-domain]  Cd Length: 255  Bit Score: 259.51  E-value: 3.58e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   10 LNDGHFMPVLGFGTYApaeVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSkiadGSVKREDIFYTSKLWSNS 89
Cdd:cd19132   1 LNDGTQIPAIGFGTYP---LKGDEGVEAVVAALQAGYRLLDTAFNYENEGAVGEAVRR----SGVPREELFVTTKLPGRH 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   90 HRPELVRPALERSLKNLQLDYVDLYLIHFPVsvkpgeeviPKdeNGKILfdtvdlcATWEAMEKCKDAGLAKSIGVSNFN 169
Cdd:cd19132  74 HGYEEALRTIEESLYRLGLDYVDLYLIHWPN---------PS--RDLYV-------EAWQALIEAREEGLVRSIGVSNFL 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  170 HRLLEMILNKPGLKykPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREepwvdpnspvLLEDPVLCALAKKHK 249
Cdd:cd19132 136 PEHLDRLIDETGVT--PAVNQIELHPYFPQAEQRAYHREHGIVTQSWSPLGRGSG----------LLDEPVIKAIAEKHG 203

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 4503285  250 RTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNR 301
Cdd:cd19132 204 KTPAQVVLRWHVQLGVVPIPKSANPERQRENLAIFDFELSDEDMAAIAALDR 255
AKR_AKR3D1 cd19121
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ...
 9-299 1.76e-84

AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.


Pssm-ID: 381347 [Multi-domain]  Cd Length: 279  Bit Score: 255.92  E-value: 1.76e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285    9 KLNDGHFMPVLGFGTYapaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGsVKREDIFYTSKLWSN 88
Cdd:cd19121   5 KLNTGASIPAVGLGTW---QAKAGEVKAAVAHALKIGYRHIDGALCYQNEDEVGEGIKEAIAGG-VKREDLFVTTKLWST 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   89 SH-RPELvrpALERSLKNLQLDYVDLYLIHFPVSVKP--GEEVIPKDENGKILFD-TVDLCATWEAMEKCKDAGLAKSIG 164
Cdd:cd19121  81 YHrRVEL---CLDRSLKSLGLDYVDLYLVHWPVLLNPngNHDLFPTLPDGSRDLDwDWNHVDTWKQMEKVLKTGKTKAIG 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  165 VSNFNHRLLEMILnkPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGShreepwvdPNSPVLLEDPVLcAL 244
Cdd:cd19121 158 VSNYSIPYLEELL--KHATVVPAVNQVENHPYLPQQELVDFCKEKGILIEAYSPLGS--------TGSPLISDEPVV-EI 226

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 4503285  245 AKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFqlTSEEMKAIDGL 299
Cdd:cd19121 227 AKKHNVGPGTVLISYQVARGAVVLPKSVTPDRIKSNLEIIDL--DDEDMNKLNDI 279
AKR_AKR3F3 cd19140
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ...
 13-299 5.21e-83

Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381366 [Multi-domain]  Cd Length: 253  Bit Score: 251.41  E-value: 5.21e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   13 GHFMPVLGFGTYapaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIrskiADGSVKREDIFYTSKLWSNSHRP 92
Cdd:cd19140   5 GVRIPALGLGTY---PLTGEECTRAVEHALELGYRHIDTAQMYGNEAQVGEAI----AASGVPRDELFLTTKVWPDNYSP 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   93 ELVRPALERSLKNLQLDYVDLYLIHFPvsvkpgeeviPKDengkilfdtVDLCATWEAMEKCKDAGLAKSIGVSNFNHRL 172
Cdd:cd19140  78 DDFLASVEESLRKLRTDYVDLLLLHWP----------NKD---------VPLAETLGALNEAQEAGLARHIGVSNFTVAL 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  173 LEMILNKPGLKYkpVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHReepwvdpnspvLLEDPVLCALAKKHKRTP 252
Cdd:cd19140 139 LREAVELSEAPL--FTNQVEYHPYLDQRKLLDAAREHGIALTAYSPLARGE-----------VLKDPVLQEIGRKHGKTP 205

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 4503285  253 ALIALRYQLQR-GVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGL 299
Cdd:cd19140 206 AQVALRWLLQQeGVAAIPKATNPERLEENLDIFDFTLSDEEMARIAAL 253
AKR_AKR5A1_2 cd19156
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ...
 8-305 1.73e-82

AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.


Pssm-ID: 381382 [Multi-domain]  Cd Length: 266  Bit Score: 250.51  E-value: 1.73e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285    8 VKLNDGHFMPVLGFGTYapaEVPK-SKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKiadgSVKREDIFYTSKLW 86
Cdd:cd19156   1 VKLANGVEMPRLGLGVW---RVQDgAEAENAVKWAIEAGYRHIDTAAIYKNEEGVGQGIRES----GVPREEVFVTTKLW 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   87 SNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPgeevipKDengkilfdtvdlcaTWEAMEKCKDAGLAKSIGVS 166
Cdd:cd19156  74 NSDQGYESTLAAFEESLEKLGLDYVDLYLIHWPVKGKF------KD--------------TWKAFEKLYKEKKVRAIGVS 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  167 NFNHRLLEMILNKpgLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHReepwvdpnspvLLEDPVLCALAK 246
Cdd:cd19156 134 NFHEHHLEELLKS--CKVAPMVNQIELHPLLTQEPLRKFCKEKNIAVEAWSPLGQGK-----------LLSNPVLKAIGK 200

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 4503285  247 KHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRY 305
Cdd:cd19156 201 KYGKSAAQVIIRWDIQHGIITIPKSVHEERIQENFDVFDFELTAEEIRQIDGLNTDHRY 259
AKR_AKR5B1 cd19127
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ...
 8-300 5.53e-82

AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.


Pssm-ID: 381353 [Multi-domain]  Cd Length: 268  Bit Score: 249.25  E-value: 5.53e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285    8 VKLNDGHFMPVLGFGTYApaeVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKiadgSVKREDIFYTSKLWS 87
Cdd:cd19127   1 ITLNNGVEMPALGLGVFQ---TPPEETADAVATALADGYRLIDTAAAYGNEREVGEGIRRS----GVDRSDIFVTTKLWI 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   88 NSHRPELVRPALERSLKNLQLDYVDLYLIHFPVsvkpgeevipkdengKILFDtvDLCATWEAMEKCKDAGLAKSIGVSN 167
Cdd:cd19127  74 SDYGYDKALRGFDASLRRLGLDYVDLYLLHWPV---------------PNDFD--RTIQAYKALEKLLAEGRVRAIGVSN 136

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  168 FNHRLLEMILNKPGLKykPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGS-HREEPWVDPNSPVLLEDPVLCALAK 246
Cdd:cd19127 137 FTPEHLERLIDATTVV--PAVNQVELHPYFSQKDLRAFHRRLGIVTQAWSPIGGvMRYGASGPTGPGDVLQDPTITGLAE 214

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 4503285  247 KHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN 300
Cdd:cd19127 215 KYGKTPAQIVLRWHLQNGVSAIPKSVHPERIAENIDIFDFALSAEDMAAIDALD 268
AKR_AKR3C1 cd19119
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ...
 8-301 3.82e-78

Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).


Pssm-ID: 381345 [Multi-domain]  Cd Length: 294  Bit Score: 240.48  E-value: 3.82e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285    8 VKLNDGHFMPVLGFGTYAPAEvPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWS 87
Cdd:cd19119   4 FKLNTGASIPALGLGTASPHE-DRAEVKEAVEAAIKEGYRHIDTAYAYETEDFVGEAIKRAIDDGSIKREELFITTKVWP 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   88 NSHRPelVRPALERSLKNLQLDYVDLYLIHFPVSVK-----PGEEVIPKDENGKILF-DTVDLCATWEAMEKCKDAGLAK 161
Cdd:cd19119  83 TFYDE--VERSLDESLKALGLDYVDLLLVHWPVCFEkdsddSGKPFTPVNDDGKTRYaASGDHITTYKQLEKIYLDGRAK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  162 SIGVSNFNHRLLEMILNKpgLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEpwvdpnspvLLEDPVL 241
Cdd:cd19119 161 AIGVSNYSIVYLERLIKE--CKVVPAVNQVELHPHLPQMDLRDFCFKHGILVTAYSPLGSHGAP---------NLKNPLV 229

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  242 CALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVfeFQLTSEEMKAIDGLNR 301
Cdd:cd19119 230 KKIAEKYNVSTGDILISYHVRQGVIVLPKSLKPVRIVSNGKI--VSLTKEDLQKLDDIGE 287
AKR_AKR2C1 cd19114
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ...
 13-311 1.01e-77

AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.


Pssm-ID: 381340 [Multi-domain]  Cd Length: 302  Bit Score: 239.77  E-value: 1.01e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   13 GHFMPVLGFGTYapaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSNSHRP 92
Cdd:cd19114   1 GDKMPLVGFGTA---KIKANETEEVIYNAIKVGYRLIDGALLYGNEAEVGRGIRKAIQEGLVKREDLFIVTKLWNNFHGK 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   93 ELVRPALERSLKNLQLDYVDLYLIHFPVS---VKPGEEVIP---KDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVS 166
Cdd:cd19114  78 DHVREAFDRQLKDYGLDYIDLYLIHFPIPaayVDPAENYPFlwkDKELKKFPLEQSPMQECWREMEKLVDAGLVRNIGIA 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  167 NFNHRLLEMILNKPglKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPV--LLEDPVLCAL 244
Cdd:cd19114 158 NFNVQLILDLLTYA--KIKPAVLQIEHHPYLQQKRLIDWAKKQGIQITAYSSFGNAVYTKVTKHLKHFtnLLEHPVVKKL 235

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4503285  245 AKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIF 311
Cdd:cd19114 236 ADKHKRDTGQVLLRWAVQRNITVIPKSVNVERMKTNLDITSYKLDEEDMEALYELEANARFNDPVVY 302
AKR_CeZK1290-like cd19135
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ...
 7-299 1.09e-76

Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.


Pssm-ID: 381361 [Multi-domain]  Cd Length: 265  Bit Score: 235.68  E-value: 1.09e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285    7 CVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKlaiEAGFHHIDSAHVYNNEEQVGLAIRskiaDGSVKREDIFYTSKLW 86
Cdd:cd19135   4 TVRLSNGVEMPILGLGTSHSGGYSHEAVVYALK---ECGYRHIDTAKRYGCEELLGKAIK----ESGVPREDLFLTTKLW 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   87 SNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGeevipkDENGKILFDTvdlcatWEAMEKCKDAGLAKSIGVS 166
Cdd:cd19135  77 PSDYGYESTKQAFEASLKRLGVDYLDLYLLHWPDCPSSG------KNVKETRAET------WRALEELYDEGLCRAIGVS 144

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  167 NFNHRLLEMILNKPGLKykPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHReepwvdpnspvLLEDPVLCALAK 246
Cdd:cd19135 145 NFLIEHLEQLLEDCSVV--PHVNQVEFHPFQNPVELIEYCRDNNIVFEGYCPLAKGK-----------ALEEPTVTELAK 211

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 4503285  247 KHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGL 299
Cdd:cd19135 212 KYQKTPAQILIRWSIQNGVVTIPKSTKEERIKENCQVFDFSLSEEDMATLDSL 264
AKR_AKR5C1 cd19130
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ...
 10-300 3.50e-75

Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.


Pssm-ID: 381356 [Multi-domain]  Cd Length: 256  Bit Score: 231.72  E-value: 3.50e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   10 LNDGHFMPVLGFGTYapaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIrskiADGSVKREDIFYTSKLWSNS 89
Cdd:cd19130   4 LNDGNSIPQLGYGVF---KVPPADTQRAVATALEVGYRHIDTAAIYGNEEGVGAAI----AASGIPRDELFVTTKLWNDR 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   90 HRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPgeevipkdengkilfdtvDLCATWEAMEKCKDAGLAKSIGVSNFN 169
Cdd:cd19130  77 HDGDEPAAAFAESLAKLGLDQVDLYLVHWPTPAAG------------------NYVHTWEAMIELRAAGRTRSIGVSNFL 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  170 HRLLEMILNKPGLKykPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHReepwvdpnspvLLEDPVLCALAKKHK 249
Cdd:cd19130 139 PPHLERIVAATGVV--PAVNQIELHPAYQQRTIRDWAQAHDVKIEAWSPLGQGK-----------LLGDPPVGAIAAAHG 205

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 4503285  250 RTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN 300
Cdd:cd19130 206 KTPAQIVLRWHLQKGHVVFPKSVRRERMEDNLDVFDFDLTDTEIAAIDALD 256
AKR_AKR5H1 cd19134
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ...
 8-305 4.99e-74

AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.


Pssm-ID: 381360 [Multi-domain]  Cd Length: 263  Bit Score: 228.97  E-value: 4.99e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285    8 VKLNDGHFMPVLGFGTyapAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKiadgSVKREDIFYTSKLWS 87
Cdd:cd19134   3 VTLNDDNTMPVIGLGV---GELSDDEAERSVSAALEAGYRLIDTAAAYGNEAAVGRAIAAS----GIPRGELFVTTKLAT 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   88 NSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSvkpgeevipkdENGKIlfdtVDlcaTWEAMEKCKDAGLAKSIGVSN 167
Cdd:cd19134  76 PDQGFTASQAACRASLERLGLDYVDLYLIHWPAG-----------REGKY----VD---SWGGLMKLREEGLARSIGVSN 137

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  168 FNHRLLEMILNKPGlkYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHReepwvdpnspvLLEDPVLCALAKK 247
Cdd:cd19134 138 FTAEHLENLIDLTF--FTPAVNQIELHPLLNQAELRKVNAQHGIVTQAYSPLGVGR-----------LLDNPAVTAIAAA 204

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 4503285  248 HKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRY 305
Cdd:cd19134 205 HGRTPAQVLLRWSLQLGNVVISRSSNPERIASNLDVFDFELTADHMDALDGLDDGTRF 262
Aldo_ket_red pfam00248
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...
 19-300 1.71e-70

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.


Pssm-ID: 425554 [Multi-domain]  Cd Length: 290  Bit Score: 220.65  E-value: 1.71e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285     19 LGFGTYA----PAEVPKSKALEAVKLAIEAGFHHIDSAHVYN---NEEQVGLAIrskiADGSVKREDIFYTSKL------ 85
Cdd:pfam00248   1 IGLGTWQlgggWGPISKEEALEALRAALEAGINFIDTAEVYGdgkSEELLGEAL----KDYPVKRDKVVIATKVpdgdgp 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285     86 WSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPvsvkpgeevipkdengkilFDTVDLCATWEAMEKCKDAGLAKSIGV 165
Cdd:pfam00248  77 WPSGGSKENIRKSLEESLKRLGTDYIDLYYLHWP-------------------DPDTPIEETWDALEELKKEGKIRAIGV 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285    166 SNFNHRLLEMILNKPglKYKPVCNQVECHPYF--NQRKLLDFCKSKDIVLVAYSALGS----------------HREEPW 227
Cdd:pfam00248 138 SNFDAEQIEKALTKG--KIPIVAVQVEYNLLRrrQEEELLEYCKKNGIPLIAYSPLGGglltgkytrdpdkgpgERRRLL 215

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4503285    228 VDPNSPVLLEDPVLCALAKKHKRTPALIALRY--QLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN 300
Cdd:pfam00248 216 KKGTPLNLEALEALEEIAKEHGVSPAQVALRWalSKPGVTIPIPGASNPEQLEDNLGALEFPLSDEEVARIDELL 290
AKR_AKR3F2 cd19139
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ...
 16-299 2.38e-69

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381365 [Multi-domain]  Cd Length: 248  Bit Score: 216.45  E-value: 2.38e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   16 MPVLGFGTY--APAEVPKSkaleaVKLAIEAGFHHIDSAHVYNNEEQVGLAIrskiADGSVKREDIFYTSKLWSNSHRPE 93
Cdd:cd19139   1 IPAFGLGTFrlKDDVVIDS-----VRTALELGYRHIDTAQIYDNEAAVGQAI----AESGVPRDELFITTKIWIDNLSKD 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   94 LVRPALERSLKNLQLDYVDLYLIHFPVsvkpgeeviPKDEngkilfdtVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLL 173
Cdd:cd19139  72 KLLPSLEESLEKLRTDYVDLTLIHWPS---------PNDE--------VPVEEYIGALAEAKEQGLTRHIGVSNFTIALL 134

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  174 EMILNKPGlKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHReepwvdpnspvLLEDPVLCALAKKHKRTPA 253
Cdd:cd19139 135 DEAIAVVG-AGAIATNQIELSPYLQNRKLVAHCKQHGIHVTSYMTLAYGK-----------VLDDPVLAAIAERHGATPA 202

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 4503285  254 LIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGL 299
Cdd:cd19139 203 QIALAWAMARGYAVIPSSTKREHLRSNLLALDLTLDADDMAAIAAL 248
AKR_AKR3E1 cd19122
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ...
 9-297 8.02e-67

AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.


Pssm-ID: 381348 [Multi-domain]  Cd Length: 291  Bit Score: 211.33  E-value: 8.02e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285    9 KLNDGHFMPVLGFGTYApAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADG-SVKREDIFYTSKLWS 87
Cdd:cd19122   2 TLNNGVKIPAVGFGTFA-NEGAKGETYAAVTKALDVGYRHLDCAWFYLNEDEVGDAVRDFLKENpSVKREDLFICTKVWN 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   88 NSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPK-DENGK--ILFD-TVDLCATWEAMEKCKDAGLAKSI 163
Cdd:cd19122  81 HLHEPEDVKWSIDNSLKNLKLDYIDLFLVHWPIAAEKNDQRSPKlGPDGKyvILKDlTENPEPTWRAMEEIYESGKAKAI 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  164 GVSNFNHRLLEMILNKPglKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPwvdPNSPVLLEDPVLCA 243
Cdd:cd19122 161 GVSNWTIPGLKKLLSFA--KVKPHVNQIEIHPFLPNEELVDYCFSNDILPEAYSPLGSQNQVP---STGERVSENPTLNE 235

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 4503285  244 LAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEfqLTSEEMKAID 297
Cdd:cd19122 236 VAEKGGYSLAQVLIAWGLRRGYVVLPKSSTPSRIESNFKSIE--LSDEDFEAIN 287
dkgA PRK11565
2,5-didehydrogluconate reductase DkgA;
8-304 8.45e-66

2,5-didehydrogluconate reductase DkgA;


Pssm-ID: 183203 [Multi-domain]  Cd Length: 275  Bit Score: 208.00  E-value: 8.45e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285     8 VKLNDGHFMPVLGFGTYapaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSkiadGSVKREDIFYTSKLWS 87
Cdd:PRK11565   7 IKLQDGNVMPQLGLGVW---QASNEEVITAIHKALEVGYRSIDTAAIYKNEEGVGKALKE----ASVAREELFITTKLWN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285    88 NSHRPelVRPALERSLKNLQLDYVDLYLIHFPVsvkpgeeviPKDENgkilfdTVDlcaTWEAMEKCKDAGLAKSIGVSN 167
Cdd:PRK11565  80 DDHKR--PREALEESLKKLQLDYVDLYLMHWPV---------PAIDH------YVE---AWKGMIELQKEGLIKSIGVCN 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   168 FNHRLLEMILNKPGLKykPVCNQVECHPYFNQRKLLdfckskdivlvAYSALGSHREEPWvdpnSPV------LLEDPVL 241
Cdd:PRK11565 140 FQIHHLQRLIDETGVT--PVINQIELHPLMQQRQLH-----------AWNATHKIQTESW----SPLaqggkgVFDQKVI 202

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4503285   242 CALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVR 304
Cdd:PRK11565 203 RDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVFDFRLDKDELGEIAKLDQGKR 265
AKR_AKR3F1-like cd19072
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ...
 16-297 5.42e-65

Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381298 [Multi-domain]  Cd Length: 263  Bit Score: 205.54  E-value: 5.42e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   16 MPVLGFGTYA---PAEVPKS---KALEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRSkiadgsVKREDIFYTSKLW 86
Cdd:cd19072   4 VPVLGLGTWGiggGMSKDYSddkKAIEALRYAIELGINLIDTAEMYGGghaEELVGKAIKG------FDREDLFITTKVS 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   87 SNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVsvkpgeevipkdengkilfDTVDLCATWEAMEKCKDAGLAKSIGVS 166
Cdd:cd19072  78 PDHLKYDDVIKAAKESLKRLGTDYIDLYLIHWPN-------------------PSIPIEETLRAMEELVEEGKIRYIGVS 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  167 NFNHRLLEMILNKPGlKYKPVCNQVECHpYFNQR---KLLDFCKSKDIVLVAYSALGshREEPWVDPNSPVLLEdpvlca 243
Cdd:cd19072 139 NFSLEELEEAQSYLK-KGPIVANQVEYN-LFDREeesGLLPYCQKNGIAIIAYSPLE--KGKLSNAKGSPLLDE------ 208

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 4503285  244 LAKKHKRTPALIALRYQLQR-GVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAID 297
Cdd:cd19072 209 IAKKYGKTPAQIALNWLISKpNVIAIPKASNIEHLEENAGALGWELSEEDLQRLD 263
dkgB PRK11172
2,5-didehydrogluconate reductase DkgB;
16-312 1.03e-58

2,5-didehydrogluconate reductase DkgB;


Pssm-ID: 183012 [Multi-domain]  Cd Length: 267  Bit Score: 189.85  E-value: 1.03e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285    16 MPVLGFGTYapaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIrskiADGSVKREDIFYTSKLWSNSHRPELV 95
Cdd:PRK11172   3 IPAFGLGTF---RLKDQVVIDSVKTALELGYRAIDTAQIYDNEAAVGQAI----AESGVPRDELFITTKIWIDNLAKDKL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285    96 RPALERSLKNLQLDYVDLYLIHFPVsvkpgeeviPKDEngkilfdtVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEM 175
Cdd:PRK11172  76 IPSLKESLQKLRTDYVDLTLIHWPS---------PNDE--------VSVEEFMQALLEAKKQGLTREIGISNFTIALMKQ 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   176 ILNKPGlKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHReepwvdpnspvLLEDPVLCALAKKHKRTPALI 255
Cdd:PRK11172 139 AIAAVG-AENIATNQIELSPYLQNRKVVAFAKEHGIHVTSYMTLAYGK-----------VLKDPVIARIAAKHNATPAQV 206

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 4503285   256 ALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFA 312
Cdd:PRK11172 207 ILAWAMQLGYSVIPSSTKRENLASNLLAQDLQLDAEDMAAIAALDRNGRLVSPEGLA 263
AKR_YeaE cd19138
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ...
 6-297 1.02e-56

Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381364 [Multi-domain]  Cd Length: 266  Bit Score: 184.37  E-value: 1.02e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285    6 QCVKLNDGHFMPVLGFGTYAPAEVPKSKA--LEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRSKiadgsvkREDIF 80
Cdd:cd19138   1 RTVTLPDGTKVPALGQGTWYMGEDPAKRAqeIEALRAGIDLGMTLIDTAEMYGDggsEELVGEAIRGR-------RDKVF 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   81 YTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVkPGEEVIpkdengkilfdtvdlcatwEAMEKCKDAGLA 160
Cdd:cd19138  74 LVSKVLPSNASRQGTVRACERSLRRLGTDYLDLYLLHWRGGV-PLAETV-------------------AAMEELKKEGKI 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  161 KSIGVSNFNHRLLEMILNKPGLKyKPVCNQVECHpyFNQR----KLLDFCKSKDIVLVAYSALGSHREEPwvdpnsPVLL 236
Cdd:cd19138 134 RAWGVSNFDTDDMEELWAVPGGG-NCAANQVLYN--LGSRgieyDLLPWCREHGVPVMAYSPLAQGGLLR------RGLL 204

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4503285  237 EDPVLCALAKKHKRTPALIALRYQL-QRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAID 297
Cdd:cd19138 205 ENPTLKEIAARHGATPAQVALAWVLrDGNVIAIPKSGSPEHARENAAAADLELTEEDLAELD 266
AKR_AKR3F1 cd19137
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ...
 13-297 1.64e-46

Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381363 [Multi-domain]  Cd Length: 260  Bit Score: 158.12  E-value: 1.64e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   13 GHFMPVLGFGTYA------PAEVPKSKALEAVKLAIEAGFHHIDSAHVY---NNEEQVGLAIRSkiadgsVKREDIFYTS 83
Cdd:cd19137   1 GEKIPALGLGTWGiggfltPDYSRDEEMVELLKTAIELGYTHIDTAEMYgggHTEELVGKAIKD------FPREDLFIVT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   84 KLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPvsvkpgEEVIPKDEngkilfdtvdlcaTWEAMEKCKDAGLAKSI 163
Cdd:cd19137  75 KVWPTNLRYDDLLRSLQNSLRRLDTDYIDLYLIHWP------NPNIPLEE-------------TLSAMAEGVRQGLIRYI 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  164 GVSNFNHRLLEMILNKpgLKYKPVCNQVECHPY---FNQRKLLDFCKSKDIVLVAYSALgshreepwvdpNSPVLLEDPV 240
Cdd:cd19137 136 GVSNFNRRLLEEAISK--SQTPIVCNQVKYNLEdrdPERDGLLEYCQKNGITVVAYSPL-----------RRGLEKTNRT 202

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 4503285  241 LCALAKKHKRTPALIALRYQLQR-GVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAID 297
Cdd:cd19137 203 LEEIAKNYGKTIAQIALAWLIQKpNVVAIPKAGRVEHLKENLKATEIKLSEEEMKLLD 260
AKR_AKR11B1-like cd19084
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ...
 13-297 3.80e-46

AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.


Pssm-ID: 381310 [Multi-domain]  Cd Length: 296  Bit Score: 158.07  E-value: 3.80e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   13 GHFMPVLGFGTYA-----PAEVPKSKALEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRSKiadgsvkREDIFYTSK 84
Cdd:cd19084   1 DLKVSRIGLGTWAiggtwWGEVDDQESIEAIKAAIDLGINFFDTAPVYGFghsEEILGKALKGR-------RDDVVIATK 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   85 ---LWSNSH------RPELVRPALERSLKNLQLDYVDLYLIHFPvsvkpgeevipkDENgkilfdtVDLCATWEAMEKCK 155
Cdd:cd19084  74 cglRWDGGKgvtkdlSPESIRKEVEQSLRRLQTDYIDLYQIHWP------------DPN-------TPIEETAEALEKLK 134

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  156 DAGLAKSIGVSNFNhrlLEMIlnKPGLKY-KPVCNQVechPY--FNQ---RKLLDFCKSKDIVLVAYSAL------GSHR 223
Cdd:cd19084 135 KEGKIRYIGVSNFS---VEQL--EEARKYgPIVSLQP---PYsmLEReieEELLPYCRENGIGVLPYGPLaqglltGKYK 206

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  224 EEPWVDPN-----SPVLLED---------PVLCALAKKHKRTPALIALRYQLQR-GV-VVLAKSYNEQRIRQNVQVFEFQ 287
Cdd:cd19084 207 KEPTFPPDdrrsrFPFFRGEnfeknleivDKLKEIAEKYGKSLAQLAIAWTLAQpGVtSAIVGAKNPEQLEENAGALDWE 286

                       330
                ....*....|
gi 4503285  288 LTSEEMKAID 297
Cdd:cd19084 287 LTEEELKEID 296
AKR_AtPLR-like cd19093
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ...
 17-297 1.03e-42

Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.


Pssm-ID: 381319 [Multi-domain]  Cd Length: 293  Bit Score: 148.92  E-value: 1.03e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   17 PVLGFGTYA---------PAEVPKSkALEAVKLAIEAGFHHIDSAHVY---NNEEQVGLAIRskiadGSVKREDIFYTSK 84
Cdd:cd19093   3 SPLGLGTWQwgdrlwwgyGEYGDED-LQAAFDAALEAGVNLFDTAEVYgtgRSERLLGRFLK-----ELGDRDEVVIATK 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   85 L----WSNSHRPeLVRpALERSLKNLQLDYVDLYLIHFPVSVKPGeevipkdengkilfdtvdLCATWEAMEKCKDAGLA 160
Cdd:cd19093  77 FaplpWRLTRRS-VVK-ALKASLERLGLDSIDLYQLHWPGPWYSQ------------------IEALMDGLADAVEEGLV 136

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  161 KSIGVSNFNHRLLEMI---LNKPGlkYKPVCNQVE---CHPYFNQRKLLDFCKSKDIVLVAYSALG----------SHR- 223
Cdd:cd19093 137 RAVGVSNYSADQLRRAhkaLKERG--VPLASNQVEyslLYRDPEQNGLLPACDELGITLIAYSPLAqglltgkyspENPp 214

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4503285  224 EEPWVDPNSPVLLE--DPVLCAL---AKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAID 297
Cdd:cd19093 215 PGGRRRLFGRKNLEkvQPLLDALeeiAEKYGKTPAQVALNWLIAKGVVPIPGAKNAEQAEENAGALGWRLSEEEVAELD 293
PdxI COG0667
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ...
 17-297 1.98e-42

Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440431 [Multi-domain]  Cd Length: 316  Bit Score: 148.79  E-value: 1.98e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   17 PVLGFGT----YAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYN---NEEQVGLAIRSKiadgsvKREDIFYTSKL---- 85
Cdd:COG0667  14 SRLGLGTmtfgGPWGGVDEAEAIAILDAALDAGINFFDTADVYGpgrSEELLGEALKGR------PRDDVVIATKVgrrm 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   86 ----WSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPvsvkpgeevipkDENgkilfdtVDLCATWEAMEKCKDAGLAK 161
Cdd:COG0667  88 gpgpNGRGLSREHIRRAVEASLRRLGTDYIDLYQLHRP------------DPD-------TPIEETLGALDELVREGKIR 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  162 SIGVSNFN-HRLLEMILNKPGLkYKPVCNQVEchpY--FNQR---KLLDFCKSKDIVLVAYSALGS------HREEPWVD 229
Cdd:COG0667 149 YIGVSNYSaEQLRRALAIAEGL-PPIVAVQNE---YslLDRSaeeELLPAARELGVGVLAYSPLAGglltgkYRRGATFP 224

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  230 PNS--------PVLLED-----PVLCALAKKHKRTPALIALRYQLQRGVVVL----AKSynEQRIRQNVQVFEFQLTSEE 292
Cdd:COG0667 225 EGDraatnfvqGYLTERnlalvDALRAIAAEHGVTPAQLALAWLLAQPGVTSvipgARS--PEQLEENLAAADLELSAED 302


                ....*
gi 4503285  293 MKAID 297
Cdd:COG0667 303 LAALD 307
AKR_AKR11B3 cd19085
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ...
 17-303 7.68e-42

Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.


Pssm-ID: 381311 [Multi-domain]  Cd Length: 292  Bit Score: 146.58  E-value: 7.68e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   17 PVLGFGTYAPA------EVPKSKALEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRSKiadgsvkREDIFYTSKLWS 87
Cdd:cd19085   2 SRLGLGCWQFGggywwgDQDDEESIATIHAALDAGINFFDTAEAYGDghsEEVLGKALKGR-------RDDVVIATKVSP 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   88 NSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSvkpgeevipkdengkilfdTVDLCATWEAMEKCKDAGLAKSIGVSN 167
Cdd:cd19085  75 DNLTPEDVRKSCERSLKRLGTDYIDLYQIHWPSS-------------------DVPLEETMEALEKLKEEGKIRAIGVSN 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  168 FNHRLLEMILnKPGlkyKPVCNQVECHPYFNQ--RKLLDFCKSKDIVLVAYSAL------GSHREEPWVDPN-----SPV 234
Cdd:cd19085 136 FGPAQLEEAL-DAG---RIDSNQLPYNLLWRAieYEILPFCREHGIGVLAYSPLaqglltGKFSSAEDFPPGdartrLFR 211

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  235 LLEDPV----------LCALAKKHKRTPALIALRYQLQRGVV--VLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRN 302
Cdd:cd19085 212 HFEPGAeeetfealekLKEIADELGVTMAQLALAWVLQQPGVtsVIVGARNPEQLEENAAAVDLELSPSVLERLDEISDP 291


                .
gi 4503285  303 V 303
Cdd:cd19085 292 L 292
AKR_SF cd06660
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ...
 17-282 2.55e-34

Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.


Pssm-ID: 381296 [Multi-domain]  Cd Length: 232  Bit Score: 125.32  E-value: 2.55e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   17 PVLGFGTYA-PAEVPKSKALEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRskiadGSVKREDIFYTSK-----LWS 87
Cdd:cd06660   1 SRLGLGTMTfGGDGDEEEAFALLDAALEAGGNFFDTADVYGDgrsERLLGRWLK-----GRGNRDDVVIATKgghppGGD 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   88 NSHR---PELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEvipkdengkilfdtvdlcaTWEAMEKCKDAGLAKSIG 164
Cdd:cd06660  76 PSRSrlsPEHIRRDLEESLRRLGTDYIDLYYLHRDDPSTPVEE-------------------TLEALNELVREGKIRYIG 136

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  165 VSNFNHRLLEMILN--KPGLKYKPVCNQVE---CHPYFNQRKLLDFCKSKDIVLVAYSALGshreepwvdpnspvlledp 239
Cdd:cd06660 137 VSNWSAERLAEALAyaKAHGLPGFAAVQPQyslLDRSPMEEELLDWAEENGLPLLAYSPLA------------------- 197

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 4503285  240 vlcalakkhkRTPALIALRYQLQR--GVVVLAKSYNEQRIRQNVQ 282
Cdd:cd06660 198 ----------RGPAQLALAWLLSQpfVTVPIVGARSPEQLEENLA 232
AKR_unchar cd19102
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 18-299 5.86e-31

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381328 [Multi-domain]  Cd Length: 302  Bit Score: 118.16  E-value: 5.86e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   18 VLGFGTYA---------PAEVPKSKALEAVKLAIEAGFHHIDSAHVY---NNEEQVGLAIRSKiadgsvkREDIFYTSK- 84
Cdd:cd19102   3 TIGLGTWAiggggwgggWGPQDDRDSIAAIRAALDLGINWIDTAAVYglgHSEEVVGRALKGL-------RDRPIVATKc 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   85 --LW------SNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEvipkdengkilfdtvdlcaTWEAMEKCKD 156
Cdd:cd19102  76 glLWdeegriRRSLKPASIRAECEASLRRLGVDVIDLYQIHWPDPDEPIEE-------------------AWGALAELKE 136

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  157 AGLAKSIGVSNFNHRLLEMIL-------NKPGlkYKPVCNQVEchpyfnqRKLLDFCKSKDIVLVAYSALGS-------H 222
Cdd:cd19102 137 EGKVRAIGVSNFSVDQMKRCQaihpiasLQPP--YSLLRRGIE-------AEILPFCAEHGIGVIVYSPMQSglltgkmT 207

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  223 REE----PWVD--PNSPVLLED---------PVLCALAKKHKRTPALIALRYQLQRGVV--VLAKSYNEQRIRQNVQVFE 285
Cdd:cd19102 208 PERvaslPADDwrRRSPFFQEPnlarnlalvDALRPIAERHGRTVAQLAIAWVLRRPEVtsAIVGARRPDQIDETVGAAD 287

                       330
                ....*....|....
gi 4503285  286 FQLTSEEMKAIDGL 299
Cdd:cd19102 288 LRLTPEELAEIEAL 301
COG1453 COG1453
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
16-299 1.64e-28

Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];


Pssm-ID: 441062 [Multi-domain]  Cd Length: 365  Bit Score: 112.99  E-value: 1.64e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   16 MPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVY-NNEEQVGLAIRSKiadgsvkREDIFYTSKLWSNSHRPEL 94
Cdd:COG1453  13 VSVLGFGGMRLPRKDEEEAEALIRRAIDNGINYIDTARGYgDSEEFLGKALKGP-------RDKVILATKLPPWVRDPED 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   95 VRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIpkDENGkilfdtvdlcaTWEAMEKCKDAGLAKSIGVSnfNHRLLE 174
Cdd:COG1453  86 MRKDLEESLKRLQTDYIDLYLIHGLNTEEDLEKVL--KPGG-----------ALEALEKAKAEGKIRHIGFS--THGSLE 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  175 MILnkpglkykpvcNQVECHP---------YFNQR-----KLLDFCKSKDIVLVAYSALGSHReepwvdpnspvLLEDPV 240
Cdd:COG1453 151 VIK-----------EAIDTGDfdfvqlqynYLDQDnqageEALEAAAEKGIGVIIMKPLKGGR-----------LANPPE 208

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4503285  241 LCALAKKHKRTPALIALRYQLQR-GV-VVLAKSYNEQRIRQNVQVFE--FQLTSEEMKAIDGL 299
Cdd:COG1453 209 KLVELLCPPLSPAEWALRFLLSHpEVtTVLSGMSTPEQLDENLKTADnlEPLTEEELAILERL 271
AKR_unchar cd19100
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 17-281 5.05e-28

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381326 [Multi-domain]  Cd Length: 238  Bit Score: 108.72  E-value: 5.05e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   17 PVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNN-EEQVGLAIRSKiadgsvkREDIFYTSKLWSNShrPELV 95
Cdd:cd19100  12 SRLGFGGGPLGRLSQEEAAAIIRRALDLGINYFDTAPSYGDsEEKIGKALKGR-------RDKVFLATKTGARD--YEGA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   96 RPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIpkDENGkilfdtvdlcaTWEAMEKCKDAGLAKSIGVSN-FNHRLLE 174
Cdd:cd19100  83 KRDLERSLKRLGTDYIDLYQLHAVDTEEDLDQVF--GPGG-----------ALEALLEAKEEGKIRFIGISGhSPEVLLR 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  175 MIlnkpglkykpvcnqvechpyfnqrKLLDFckskDIVLVAYSALGSHREEPwvdpnspvllEDPVLCALAKKHK----- 249
Cdd:cd19100 150 AL------------------------ETGEF----DVVLFPINPAGDHIDSF----------REELLPLAREKGVgviam 191

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 4503285  250 ------------RTPALIALRYQLQRGVVVLA----KSYNEqrIRQNV 281
Cdd:cd19100 192 kvlaggrllsgdPLDPEQALRYALSLPPVDVVivgmDSPEE--LDENL 237
AKR_PsAKR cd19091
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ...
 11-297 1.10e-25

Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.


Pssm-ID: 381317 [Multi-domain]  Cd Length: 319  Bit Score: 104.23  E-value: 1.10e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   11 NDGHFMPVLGFG--TYAPAEVPKSK--------ALEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRSKiadgsvkRE 77
Cdd:cd19091   8 RSGLKVSELALGtmTFGGGGGFFGAwggvdqeeADRLVDIALDAGINFFDTADVYSEgesEEILGKALKGR-------RD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   78 DIFYTSKLW---------SNSHRPELVRpALERSLKNLQLDYVDLYLIHFPVSVKPGEEvipkdengkilfdtvdlcaTW 148
Cdd:cd19091  81 DVLIATKVRgrmgegpndVGLSRHHIIR-AVEASLKRLGTDYIDLYQLHGFDALTPLEE-------------------TL 140

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  149 EAMEKCKDAGLAKSIGVSNFNHRLLEMIL---NKPGLKyKPVCNQVechpYFN------QRKLLDFCKSKDIVLVAYSAL 219
Cdd:cd19091 141 RALDDLVRQGKVRYIGVSNFSAWQIMKALgisERRGLA-RFVALQA----YYSllgrdlEHELMPLALDQGVGLLVWSPL 215

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  220 GS-------HREEPWVD------------PNSPVLLEDPV--LCALAKKHKRTPALIALRYQLQR----GVVVLAKsyNE 274
Cdd:cd19091 216 AGgllsgkyRRGQPAPEgsrlrrtgfdfpPVDRERGYDVVdaLREIAKETGATPAQVALAWLLSRptvsSVIIGAR--NE 293

                       330       340
                ....*....|....*....|...
gi 4503285  275 QRIRQNVQVFEFQLTSEEMKAID 297
Cdd:cd19091 294 EQLEDNLGAAGLSLTPEEIARLD 316
YdhF COG4989
Predicted oxidoreductase YdhF [General function prediction only];
18-292 3.30e-25

Predicted oxidoreductase YdhF [General function prediction only];


Pssm-ID: 444013 [Multi-domain]  Cd Length: 299  Bit Score: 102.54  E-value: 3.30e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   18 VLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRSKiadgSVKREDIFYTSKL------WSN 88
Cdd:COG4989  17 VLGCMRLGEWDLSPAEAAALIEAALELGITTFDHADIYGGytcEALFGEALKLS----PSLREKIELQTKCgirlpsEAR 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   89 SHRP-------ELVRPALERSLKNLQLDYVDLYLIHFPvsvkpgeevipkdengkilfDT-VDLCATWEAMEKCKDAGLA 160
Cdd:COG4989  93 DNRVkhydtskEHIIASVEGSLRRLGTDYLDLLLLHRP--------------------DPlMDPEEVAEAFDELKASGKV 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  161 KSIGVSNFNHRLLEMiLNKpGLKYKPVCNQVECHPYFNQ---RKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLE 237
Cdd:COG4989 153 RHFGVSNFTPSQFEL-LQS-ALDQPLVTNQIELSLLHTDafdDGTLDYCQLNGITPMAWSPLAGGRLFGGFDEQFPRLRA 230

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 4503285  238 dpVLCALAKKHKRTPALIALRYqLQR---GVVVLAKSYNEQRIRQNVQVFEFQLTSEE 292
Cdd:COG4989 231 --ALDELAEKYGVSPEAIALAW-LLRhpaGIQPVIGTTNPERIKAAAAALDIELTREE 285
AKR_BsYcsN_EcYdhF-like cd19092
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ...
 18-292 3.31e-25

Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.


Pssm-ID: 381318 [Multi-domain]  Cd Length: 287  Bit Score: 102.25  E-value: 3.31e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   18 VLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRSKiadgSVKREDIFYTSK----LWSNSH 90
Cdd:cd19092  10 VLGCMRLADWGESAEELLSLIEAALELGITTFDHADIYGGgkcEELFGEALALN----PGLREKIEIQTKcgirLGDDPR 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   91 R---------PELVRPALERSLKNLQLDYVDLYLIHFPvsvkpgeevipkdengkilfDT-VDLCATWEAMEKCKDAGLA 160
Cdd:cd19092  86 PgrikhydtsKEHILASVEGSLKRLGTDYLDLLLLHRP--------------------DPlMDPEEVAEAFDELVKSGKV 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  161 KSIGVSNFNHRLLEMiLNKpGLKYKPVCNQVEC---HPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLE 237
Cdd:cd19092 146 RYFGVSNFTPSQIEL-LQS-YLDQPLVTNQIELsllHTEAIDDGTLDYCQLLDITPMAWSPLGGGRLFGGFDERFQRLRA 223

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 4503285  238 dpVLCALAKKHKRTPALIALRYQLQ---RGVVVLAkSYNEQRIRQNVQVFEFQLTSEE 292
Cdd:cd19092 224 --ALEELAEEYGVTIEAIALAWLLRhpaRIQPILG-TTNPERIRSAVKALDIELTREE 278
AKR_AKR11A1_11D1 cd19083
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ...
 38-299 5.38e-25

AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).


Pssm-ID: 381309 [Multi-domain]  Cd Length: 307  Bit Score: 102.11  E-value: 5.38e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   38 VKLAIEAGFHHIDSAHVY---NNEEQVGLAIRSKiadgsvKREDIFYTSK----------LWSNShrPELVRPALERSLK 104
Cdd:cd19083  39 VREALDNGVNLLDTAFIYglgRSEELVGEVLKEY------NRNEVVIATKgahkfggdgsVLNNS--PEFLRSAVEKSLK 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  105 NLQLDYVDLYLIHFPvsvkpgEEVIPKDEngkilfdtvdlcaTWEAMEKCKDAGLAKSIGVSNFNHRLLEMiLNKPGL-- 182
Cdd:cd19083 111 RLNTDYIDLYYIHFP------DGETPKAE-------------AVGALQELKDEGKIRAIGVSNFSLEQLKE-ANKDGYvd 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  183 ----KYKPVCNQVECHpyfnqrkLLDFCKSKDIVLVAYSAL------GSHREEPWVDPN--------------SPVLLED 238
Cdd:cd19083 171 vlqgEYNLLQREAEED-------ILPYCVENNISFIPYFPLasgllaGKYTKDTKFPDNdlrndkplfkgerfSENLDKV 243

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4503285  239 PVLCALAKKHKRTPALIALRYQLQRGVV--VLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGL 299
Cdd:cd19083 244 DKLKSIADEKGVTVAHLALAWYLTRPAIdvVIPGAKRAEQVIDNLKALDVTLTEEEIAFIDAL 306
AKR_unchar cd19105
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 13-230 5.86e-24

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381331 [Multi-domain]  Cd Length: 250  Bit Score: 98.04  E-value: 5.86e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   13 GHFMPVLGFGTYAPAevpkSKALEAVKLAIEAGFHHIDSAHVY---NNEEQVGLAIRSkiadgsVKREDIFYTSK--LWS 87
Cdd:cd19105  10 GLKVSRLGFGGGGLP----RESPELLRRALDLGINYFDTAEGYgngNSEEIIGEALKG------LRRDKVFLATKasPRL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   88 NSHRPELVRPALERSLKNLQLDYVDLYLIHfpvSVKPGEEVIPKDEngkILfdtvdlcatwEAMEKCKDAGLAKSIGVS- 166
Cdd:cd19105  80 DKKDKAELLKSVEESLKRLQTDYIDIYQLH---GVDTPEERLLNEE---LL----------EALEKLKKEGKVRFIGFSt 143

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4503285  167 --NFNHRLLEMIlnKPG------LKYKPVcnqvecHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDP 230
Cdd:cd19105 144 hdNMAEVLQAAI--ESGwfdvimVAYNFL------NQPAELEEALAAAAEKGIGVVAMKTLAGGYLQPALLS 207
AKR_Fe-S_oxidoreductase cd19096
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ...
 17-285 6.93e-24

Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381322 [Multi-domain]  Cd Length: 255  Bit Score: 98.02  E-value: 6.93e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   17 PVLGFGTY-----APAEVPKSKALEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRSkiadgsVKREDIFYTSKL-WS 87
Cdd:cd19096   1 SVLGFGTMrlpesDDDSIDEEKAIEMIRYAIDAGINYFDTAYGYGGgksEEILGEALKE------GPREKFYLATKLpPW 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   88 NSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSvkpgEEVIPKDENGKIlfdtvdlcatWEAMEKCKDAGLAKSIGVSn 167
Cdd:cd19096  75 SVKSAEDFRRILEESLKRLGVDYIDFYLLHGLNS----PEWLEKARKGGL----------LEFLEKAKKEGLIRHIGFS- 139

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  168 FnH---RLLEMILNkpglkykpvCNQVEC----HPYFNQ-----RKLLDFCKSKDIVLVAYSAL--GSHREEPwvdpnsp 233
Cdd:cd19096 140 F-HdspELLKEILD---------SYDFDFvqlqYNYLDQenqagRPGIEYAAKKGMGVIIMEPLkgGGLANNP------- 202

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 4503285  234 vlledPVLCALAKKHKRTPALIALRYQL-QRGV-VVLAKSYNEQRIRQNVQVFE 285
Cdd:cd19096 203 -----PEALAILCGAPLSPAEWALRFLLsHPEVtTVLSGMSTPEQLDENIAAAD 251
AKR_AKR15A-like cd19090
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ...
 17-288 1.09e-23

AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).


Pssm-ID: 381316 [Multi-domain]  Cd Length: 278  Bit Score: 98.01  E-value: 1.09e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   17 PVLGFGTY----APAEVPKSKALEAVKLAIEAGFHHIDSAHVYNN-EEQVGLAIRSkiadgsVKREDIFYTSKL-----W 86
Cdd:cd19090   1 SALGLGTAglggVFGGVDDDEAVATIRAALDLGINYIDTAPAYGDsEERLGLALAE------LPREPLVLSTKVgrlpeD 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   87 SNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPkdenGKILfdtvdlcatwEAMEKCKDAGLAKSIGVS 166
Cdd:cd19090  75 TADYSADRVRRSVEESLERLGRDRIDLLMIHDPERVPWVDILAP----GGAL----------EALLELKEEGLIKHIGLG 140

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  167 NFNHRLLEMILNK-------PGLKYKPvCNQVechpyfNQRKLLDFCKSKDIVLVAYSALG----SHREEPWVDPNSPVL 235
Cdd:cd19090 141 GGPPDLLRRAIETgdfdvvlTANRYTL-LDQS------AADELLPAAARHGVGVINASPLGmgllAGRPPERVRYTYRWL 213

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4503285  236 LEDPV-----LCALAKKHKRTPALIALRYQLQ----RGVVVLAKsyNEQRIRQNVQVFEFQL 288
Cdd:cd19090 214 SPELLdrakrLYELCDEHGVPLPALALRFLLRdpriSTVLVGAS--SPEELEQNVAAAEGPL 273
AKR_AKR13A1 cd19144
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ...
 11-296 1.48e-23

AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.


Pssm-ID: 381370 [Multi-domain]  Cd Length: 323  Bit Score: 98.67  E-value: 1.48e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   11 NDGHFMPVLGFGT------YAPAEvPKSKALEAVKLAIEAGFHHIDSAHVY-NNEEQVGLAIrsKIADGsvKREDIFYTS 83
Cdd:cd19144   8 RNGPSVPALGFGAmglsafYGPPK-PDEERFAVLDAAFELGCTFWDTADIYgDSEELIGRWF--KQNPG--KREKIFLAT 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   84 K-----------LWSNShRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEvipkdengkilfdtvdlcaTWEAME 152
Cdd:cd19144  83 KfgieknvetgeYSVDG-SPEYVKKACETSLKRLGVDYIDLYYQHRVDGKTPIEK-------------------TVAAMA 142

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  153 KCKDAGLAKSIGVSNFNHRLLemilnKPGLKYKPVCN-QVECHPYF-----NQRKLLDFCKSKDIVLVAYSALGS----- 221
Cdd:cd19144 143 ELVQEGKIKHIGLSECSAETL-----RRAHAVHPIAAvQIEYSPFSldierPEIGVLDTCRELGVAIVAYSPLGRgfltg 217

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  222 -------------HREEPWVDP-NSPVLLE--DPvLCALAKKHKRTPALIALRYQLQRG--VVVLAKSYNEQRIRQNVQV 283
Cdd:cd19144 218 airspddfeegdfRRMAPRFQAeNFPKNLElvDK-IKAIAKKKNVTAGQLTLAWLLAQGddIIPIPGTTKLKRLEENLGA 296

                       330
                ....*....|...
gi 4503285  284 FEFQLTSEEMKAI 296
Cdd:cd19144 297 LKVKLTEEEEKEI 309
AKR_PA4992-like cd19095
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ...
 17-176 2.64e-23

Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381321 [Multi-domain]  Cd Length: 253  Bit Score: 96.54  E-value: 2.64e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   17 PVLGFGTY----APAEVPKSKALEAVKLAIEAGFHHIDSAHVY-NNEEQVGLAIRSkiadgsVKREDIFYTSKLWSNS-- 89
Cdd:cd19095   1 SVLGLGTSgigrVWGVPSEAEAARLLNTALDLGINLIDTAPAYgRSEERLGRALAG------LRRDDLFIATKVGTHGeg 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   90 ------HRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIpkdengkilfdtvdlcatwEAMEKCKDAGLAKSI 163
Cdd:cd19095  75 grdrkdFSPAAIRASIERSLRRLGTDYIDLLQLHGPSDDELTGEVL-------------------ETLEDLKAAGKVRYI 135

                       170
                ....*....|...
gi 4503285  164 GVSNFNHRLLEMI 176
Cdd:cd19095 136 GVSGDGEELEAAI 148
AKR_AKR11B2 cd19149
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ...
 17-297 1.21e-22

Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.


Pssm-ID: 381375 [Multi-domain]  Cd Length: 315  Bit Score: 95.80  E-value: 1.21e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   17 PVLGFGTYA------PAEVPKSKALEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRSKiadgsvkREDIFYTSK--- 84
Cdd:cd19149  12 SVIGLGTWAigggpwWGGSDDNESIRTIHAALDLGINLIDTAPAYGFghsEEIVGKAIKGR-------RDKVVLATKcgl 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   85 LWSNSH----------------RPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEvipkdengkilfdtvdlcaTW 148
Cdd:cd19149  85 RWDREGgsfffvrdgvtvyknlSPESIREEVEQSLKRLGTDYIDLYQTHWQDVETPIEE-------------------TM 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  149 EAMEKCKDAGLAKSIGVSNFN-------HRLLEMILNKPglKYKPVCNQVEchpyfnqRKLLDFCKSKDIVLVAYSAL-- 219
Cdd:cd19149 146 EALEELKRQGKIRAIGASNVSveqikeyVKAGQLDIIQE--KYSMLDRGIE-------KELLPYCKKNNIAFQAYSPLeq 216

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  220 ---------------GSHRE-EPWVDPNS--PVLLEDPVLCALAKKHKRTPALIALRYQLQRG--VVVLAKSYNEQRIRQ 279
Cdd:cd19149 217 glltgkitpdrefdaGDARSgIPWFSPENreKVLALLEKWKPLCEKYGCTLAQLVIAWTLAQPgiTSALCGARKPEQAEE 296

                       330
                ....*....|....*...
gi 4503285  280 NVQVFEFQLTSEEMKAID 297
Cdd:cd19149 297 NAKAGDIRLSAEDIATMR 314
AKR_AKR13B1 cd19088
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ...
 15-289 2.31e-22

AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.


Pssm-ID: 381314 [Multi-domain]  Cd Length: 256  Bit Score: 93.82  E-value: 2.31e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   15 FMPVLGFGTYAPAEvPKSKALEAVKLAIEAGFHHIDSAHVYN---NEEQVGLAIRSKIAD-------GSVKREDifytsK 84
Cdd:cd19088   8 AMRLTGPGIWGPPA-DREEAIAVLRRALELGVNFIDTADSYGpdvNERLIAEALHPYPDDvviatkgGLVRTGP-----G 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   85 LWSNSHRPELVRPALERSLKNLQLDYVDLYLIHfpvsvkpgeevipkdengkILFDTVDLCATWEAMEKCKDAGLAKSIG 164
Cdd:cd19088  82 WWGPDGSPEYLRQAVEASLRRLGLDRIDLYQLH-------------------RIDPKVPFEEQLGALAELQDEGLIRHIG 142

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  165 VSNFNHRLLEMILNKPGLkykpVCNQVECHPYFNQ-RKLLDFCKSKDIVLVAYSALGSHreepwvdpnsPVLLEDPVLCA 243
Cdd:cd19088 143 LSNVTVAQIEEARAIVRI----VSVQNRYNLANRDdEGVLDYCEAAGIAFIPWFPLGGG----------DLAQPGGLLAE 208

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 4503285  244 LAKKHKRTPALIALRYQLQRG--VVVLAKSYNEQRIRQNVQVFEFQLT 289
Cdd:cd19088 209 VAARLGATPAQVALAWLLARSpvMLPIPGTSSVEHLEENLAAAGLRLS 256
AKR_unchar cd19101
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 31-297 1.60e-21

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381327 [Multi-domain]  Cd Length: 304  Bit Score: 92.66  E-value: 1.60e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   31 KSKALEAVKLAIEAGFHHIDSAHVYNN-EEQVGLAIRSKIADGSVKREDIFYTsKLWSNSHR----PELVRPALERSLKN 105
Cdd:cd19101  22 EDAAVRAMAAYVDAGLTTFDCADIYGPaEELIGEFRKRLRRERDAADDVQIHT-KWVPDPGEltmtRAYVEAAIDRSLKR 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  106 LQLDYVDLYLIHFpvsvkpgeevipKDENGKILFDTVdlcatwEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPglkYK 185
Cdd:cd19101 101 LGVDRLDLVQFHW------------WDYSDPGYLDAA------KHLAELQEEGKIRHLGLTNFDTERLREILDAG---VP 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  186 PVCNQVEcHPYFNQR---KLLDFCKSKDIVLVAYSALGS---------HREEPWVDPNSPV------------------- 234
Cdd:cd19101 160 IVSNQVQ-YSLLDRRpenGMAALCEDHGIKLLAYGTLAGgllsekylgVPEPTGPALETRSlqkyklmidewggwdlfqe 238

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4503285  235 LLEdpVLCALAKKHKRTPALIALRYQLQR----GVVVLAKsyNEQRIRQNVQVFEFQLTSEEMKAID 297
Cdd:cd19101 239 LLR--TLKAIADKHGVSIANVAVRWVLDQpgvaGVIVGAR--NSEHIDDNVRAFSFRLDDEDRAAID 301
AKR_AKR11C1 cd19086
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ...
 18-221 4.31e-21

AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.


Pssm-ID: 381312 [Multi-domain]  Cd Length: 238  Bit Score: 89.84  E-value: 4.31e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   18 VLGFGTYA-----PAEVPKSKALEAVKLAIEAGFHHIDSAHVY---NNEEQVGLAIRSKiadgsvkREDIFYTSKL---- 85
Cdd:cd19086   5 EIGFGTWGlggdwWGDVDDAEAIRALRAALDLGINFFDTADVYgdgHSERLLGKALKGR-------RDKVVIATKFgnrf 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   86 -----WSNSHRPELVRPALERSLKNLQLDYVDLYLIHfpvsvKPGEEVIPKDEngkilfdtvdlcaTWEAMEKCKDAGLA 160
Cdd:cd19086  78 dggpeRPQDFSPEYIREAVEASLKRLGTDYIDLYQLH-----NPPDEVLDNDE-------------LFEALEKLKQEGKI 139

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4503285  161 KSIGVS-NFNHRLLEMILNkpglkYKPVCNQVECHPyFNQR---KLLDFCKSKDIVLVAYSALGS 221
Cdd:cd19086 140 RAYGVSvGDPEEALAALRR-----GGIDVVQVIYNL-LDQRpeeELFPLAEEHGVGVIARVPLAS 198
AKR_AKR11B1 cd19148
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ...
 33-297 4.90e-21

Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381374 [Multi-domain]  Cd Length: 302  Bit Score: 91.21  E-value: 4.90e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   33 KALEAVKLAIEAGFHHIDSAHVYN---NEEQVGLAIRskiadGSVKREDIFYTSKL---WSNSH------RPELVRPALE 100
Cdd:cd19148  26 EAIETIHKALDLGINLIDTAPVYGfglSEEIVGKALK-----EYGKRDRVVIATKVgleWDEGGevvrnsSPARIRKEVE 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  101 RSLKNLQLDYVDLYLIHFPVSVKPGEEvipkdengkilfdtvdlcaTWEAMEKCKDAGLAKSIGVSNFNHRLLEmilnkp 180
Cdd:cd19148 101 DSLRRLQTDYIDLYQVHWPDPLVPIEE-------------------TAEALKELLDEGKIRAIGVSNFSPEQME------ 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  181 glKYKPVCNQVECHPYFN------QRKLLDFCKSKDIVLVAYSAL---------GSHREEPWVD----------PNSPVL 235
Cdd:cd19148 156 --TFRKVAPLHTVQPPYNlfereiEKDVLPYARKHNIVTLAYGALcrgllsgkmTKDTKFEGDDlrrtdpkfqePRFSQY 233

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4503285  236 LEdPV--LCALAKKH--KRTPALiALRYQLQRG--VVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAID 297
Cdd:cd19148 234 LA-AVeeLDKLAQERygKSVIHL-AVRWLLDQPgvSIALWGARKPEQLDAVDEVFGWSLNDEDMKEID 299
AKR_EcYajO-like cd19079
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ...
 29-297 3.01e-20

Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.


Pssm-ID: 381305 [Multi-domain]  Cd Length: 312  Bit Score: 89.18  E-value: 3.01e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   29 VPKSKALEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRSKIadgsvKREDIFYTSKLWSNSH---------RPELVR 96
Cdd:cd19079  32 LDEEESRPIIKRALDLGINFFDTANVYSGgasEEILGRALKEFA-----PRDEVVIATKVYFPMGdgpngrglsRKHIMA 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   97 pALERSLKNLQLDYVDLYLIHFPvsvkpgeevipkDENgkilfdtVDLCATWEAMEKCKDAGLAKSIGVSN-FNHRLLEM 175
Cdd:cd19079 107 -EVDASLKRLGTDYIDLYQIHRW------------DYE-------TPIEETLEALHDVVKSGKVRYIGASSmYAWQFAKA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  176 --ILNKPGLKyKPVCNQvechPYFN------QRKLLDFCKSKDIVLVAYSALGSHR---------EEPWVDPNSPVLLED 238
Cdd:cd19079 167 lhLAEKNGWT-KFVSMQ----NHYNllyreeEREMIPLCEEEGIGVIPWSPLARGRlarpwgdttERRRSTTDTAKLKYD 241

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4503285  239 -------PVLCA---LAKKHKRTPALIALRYQLQRGVVV-----LAKSYneqRIRQNVQVFEFQLTSEEMKAID 297
Cdd:cd19079 242 yfteadkEIVDRveeVAKERGVSMAQVALAWLLSKPGVTapivgATKLE---HLEDAVAALDIKLSEEEIKYLE 312
AKR_unchar cd19099
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 19-259 7.93e-20

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381325 [Multi-domain]  Cd Length: 316  Bit Score: 88.14  E-value: 7.93e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   19 LGFGTY--APAEVPKSKALEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRSKIADGSVKREDIFYTSK--------- 84
Cdd:cd19099   6 LGLGTYrgDSDDETDEEYREALKAALDSGINVIDTAINYRGgrsERLIGKALRELIEKGGIKRDEVVIVTKagyipgdgd 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   85 -------------------------LWSNSHrPELVRPALERSLKNLQLDYVDLYLIHFPvsvkpgEEVIPKDeNGKILF 139
Cdd:cd19099  86 eplrplkyleeklgrglidvadsagLRHCIS-PAYLEDQIERSLKRLGLDTIDLYLLHNP------EEQLLEL-GEEEFY 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  140 DTVDlcATWEAMEKCKDAGLAKSIGVSNFN----------HRLLEMIL--------NKPGLK-----YKPVCNQVECHPY 196
Cdd:cd19099 158 DRLE--EAFEALEEAVAEGKIRYYGISTWDgfrappalpgHLSLEKLVaaaeevggDNHHFKviqlpLNLLEPEALTEKN 235

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4503285  197 FNQRK---LLDFCKSKDIVLVAYSALGShreepwVDPNSPVLLEDPvlcaLAKKHKRTPALIALRY 259
Cdd:cd19099 236 TVKGEalsLLEAAKELGLGVIASRPLNQ------GQLLGELRLADL----LALPGGATLAQRALQF 291
AKR_AKR9C1 cd19081
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ...
 42-297 4.81e-19

AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).


Pssm-ID: 381307 [Multi-domain]  Cd Length: 308  Bit Score: 85.73  E-value: 4.81e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   42 IEAGFHHIDSAHVYNN----------EEQVGLAIRSkiadgSVKREDIFYTSKL--WSNSHRPEL----VRPALERSLKN 105
Cdd:cd19081  36 VDAGGNFIDTADVYSAwvpgnaggesETIIGRWLKS-----RGKRDRVVIATKVgfPMGPNGPGLsrkhIRRAVEASLRR 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  106 LQLDYVDLYLIHFPvsvkpgeevipkDENgkilfdtVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILN---KPGL 182
Cdd:cd19081 111 LQTDYIDLYQAHWD------------DPA-------TPLEETLGALNDLIRQGKVRYIGASNYSAWRLQEALElsrQHGL 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  183 KyKPVCNQvechPYFN-------QRKLLDFCKSKDIVLVAYSALGS-------HREEP--------------WVDPNSPV 234
Cdd:cd19081 172 P-RYVSLQ----PEYNlvdresfEGELLPLCREEGIGVIPYSPLAGgfltgkyRSEADlpgstrrgeaakryLNERGLRI 246

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4503285  235 LledPVLCALAKKHKRTPALIALRYQLQRGVV--VLAKSYNEQRIRQNVQVFEFQLTSEEMKAID 297
Cdd:cd19081 247 L---DALDEVAAEHGATPAQVALAWLLARPGVtaPIAGARTVEQLEDLLAAAGLRLTDEEVARLD 308
AKR_AKR13A_13D cd19076
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ...
 17-296 5.26e-18

AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.


Pssm-ID: 381302 [Multi-domain]  Cd Length: 303  Bit Score: 82.65  E-value: 5.26e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   17 PVLGFGT------YAPAEVPKSKALeaVKLAIEAGFHHIDSAHVY---NNEEQVGLAIRSKiadgsvkREDIFYTSK--- 84
Cdd:cd19076  13 SALGLGCmgmsafYGPADEEESIAT--LHRALELGVTFLDTADMYgpgTNEELLGKALKDR-------RDEVVIATKfgi 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   85 LWS-------NSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEvipkdengkilfdtvdlcaTWEAMEKCKDA 157
Cdd:cd19076  84 VRDpgsgfrgVDGRPEYVRAACEASLKRLGTDVIDLYYQHRVDPNVPIEE-------------------TVGAMAELVEE 144

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  158 GLAKSIGVSNFN-------HRL-----LEMilnkpglKYKPVCNQVEchpyfnqRKLLDFCKSKDIVLVAYSALG----- 220
Cdd:cd19076 145 GKVRYIGLSEASadtirraHAVhpitaVQS-------EYSLWTRDIE-------DEVLPTCRELGIGFVAYSPLGrgflt 210

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  221 ------SHREEPWVDPNSP-----------VLLEdpVLCALAKKHKRTPALIALRYQLQRG--VVVLAKSYNEQRIRQNV 281
Cdd:cd19076 211 gaikspEDLPEDDFRRNNPrfqgenfdknlKLVE--KLEAIAAEKGCTPAQLALAWVLAQGddIVPIPGTKRIKYLEENV 288

                       330
                ....*....|....*
gi 4503285  282 QVFEFQLTSEEMKAI 296
Cdd:cd19076 289 GALDVVLTPEELAEI 303
Aldo_ket_red_shaker-like cd19074
Shaker potassium channel beta subunit family and similar proteins; This family includes ...
 18-291 1.82e-17

Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.


Pssm-ID: 381300 [Multi-domain]  Cd Length: 297  Bit Score: 81.10  E-value: 1.82e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   18 VLGFGTYAP--AEVPKSKALEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRSkiadgsVKREDIFYTSKL-WSNSHR 91
Cdd:cd19074   6 ELSLGTWLTfgGQVDDEDAKACVRKAYDLGINFFDTADVYAAgqaEEVLGKALKG------WPRESYVISTKVfWPTGPG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   92 PE---LVRP----ALERSLKNLQLDYVDLYLIHfpvsvKPGEEViPKDEngkilfdtvdlcaTWEAMEKCKDAGLAKSIG 164
Cdd:cd19074  80 PNdrgLSRKhifeSIHASLKRLQLDYVDIYYCH-----RYDPET-PLEE-------------TVRAMDDLIRQGKILYWG 140

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  165 VSNFN-HRLLEM--ILNKPGLkYKPVCNQVECHpYFNQRK---LLDFCKSKDIVLVAYSAL-----------------GS 221
Cdd:cd19074 141 TSEWSaEQIAEAhdLARQFGL-IPPVVEQPQYN-MLWREIeeeVIPLCEKNGIGLVVWSPLaqglltgkyrdgipppsRS 218

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4503285  222 HREEPWVDPNSPVLLEDPV------LCALAKKHKRTPALIALRYQLQR-GV--VVLAKSYNEQrIRQNVQVFEFQLTSE 291
Cdd:cd19074 219 RATDEDNRDKKRRLLTDENlekvkkLKPIADELGLTLAQLALAWCLRNpAVssAIIGASRPEQ-LEENVKASGVKLSPE 296
AKR_galDH cd19163
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ...
 16-294 7.01e-17

L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).


Pssm-ID: 381389 [Multi-domain]  Cd Length: 293  Bit Score: 79.52  E-value: 7.01e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   16 MPVLGFGTyAPA-----EVPKSKALEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRSkiadgsVKREDIFYTSK--- 84
Cdd:cd19163  13 VSKLGFGA-SPLggvfgPVDEEEAIRTVHEALDSGINYIDTAPWYGQgrsETVLGKALKG------IPRDSYYLATKvgr 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   85 ---LWSNS--HRPELVRPALERSLKNLQLDYVDLYLIHfPVSVKPGEEVIpkdengkilfdtvdLCATWEAMEKCKDAGL 159
Cdd:cd19163  86 yglDPDKMfdFSAERITKSVEESLKRLGLDYIDIIQVH-DIEFAPSLDQI--------------LNETLPALQKLKEEGK 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  160 AKSIGVSNFNHRLLEMILNKPG------LKYkpvcnqveCHpY--FNQR--KLLDFCKSKDIVLVAYSALG----SHREE 225
Cdd:cd19163 151 VRFIGITGYPLDVLKEVLERSPvkidtvLSY--------CH-YtlNDTSllELLPFFKEKGVGVINASPLSmgllTERGP 221

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4503285  226 PwvdPNSPVLLEDPVLCALAKKHKRTP----ALIALRYQLQ--RGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMK 294
Cdd:cd19163 222 P---DWHPASPEIKEACAKAAAYCKSRgvdiSKLALQFALSnpDIATTLVGTASPENLRKNLEAAEEPLDAHLLA 293
AKR_unchar cd19104
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 34-299 7.37e-17

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381330 [Multi-domain]  Cd Length: 321  Bit Score: 79.62  E-value: 7.37e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   34 ALEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRSKiadgsvkREDIFYTSKL-WSNSHRPEL---VRPALERSLKNL 106
Cdd:cd19104  34 QIAAVRRALDLGINFFDTAPSYGDgksEENLGRALKGL-------PAGPYITTKVrLDPDDLGDIggqIERSVEKSLKRL 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  107 QLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTvdlcATWEAMEKCKDAGLAKSIGVSNFNH-RLLEMIL--NKPG-- 181
Cdd:cd19104 107 KRDSVDLLQLHNRIGDERDKPVGGTLSTTDVLGLG----GVADAFERLRSEGKIRFIGITGLGNpPAIRELLdsGKFDav 182

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  182 ------LKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGS---------HREEPwVDPNSPVLLE----DPVLc 242
Cdd:cd19104 183 qvyynlLNPSAAEARPRGWSAQDYGGIIDAAAEHGVGVMGIRVLAAgalttsldrGREAP-PTSDSDVAIDfrraAAFR- 260

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4503285  243 ALAKKHKRTPALIALRYQL-QRGV--VVLAKSyNEQRIRQNVQVFEF-QLTSEEMKAIDGL 299
Cdd:cd19104 261 ALAREWGETLAQLAHRFALsNPGVstVLVGVK-NREELEEAVAAEAAgPLPAENLARLEAL 320
AKR_unchar cd19103
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 36-299 1.30e-16

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381329 [Multi-domain]  Cd Length: 299  Bit Score: 78.53  E-value: 1.30e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   36 EAVKLAIEAGFHHIDSAHVYnneeqvGLAIRSKIAdGSV----KREDIF----YTSKLWSNSHRPelVRPALERSLKNLQ 107
Cdd:cd19103  36 AVFDKAMAAGLNLWDTAAVY------GMGASEKIL-GEFlkryPREDYIistkFTPQIAGQSADP--VADMLEGSLARLG 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  108 LDYVDLYLIHFPVSV-KPGEEVIPKDENGKIlfdtvdlcatweamekckdaglaKSIGVSNFNH---RLLEMILNKPGLK 183
Cdd:cd19103 107 TDYIDIYWIHNPADVeRWTPELIPLLKSGKV-----------------------KHVGVSNHNLaeiKRANEILAKAGVS 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  184 YKPVCNQVE-CHPYFNQRKLLDFCKSKDIVLVAYSAL-----------------GSHREEPWvdpnSPVL--LED--PVL 241
Cdd:cd19103 164 LSAVQNHYSlLYRSSEEAGILDYCKENGITFFAYMVLeqgalsgkydtkhplpeGSGRAETY----NPLLpqLEEltAVM 239

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 4503285  242 CALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGL 299
Cdd:cd19103 240 AEIGAKHGASIAQVAIAWAIAKGTTPIIGVTKPHHVEDAARAASITLTDDEIKELEQL 297
AKR_AKR10A1_2 cd19082
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ...
 17-282 1.68e-16

AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.


Pssm-ID: 381308 [Multi-domain]  Cd Length: 291  Bit Score: 78.36  E-value: 1.68e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   17 PVLGFGT-YAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLA-------IRSKIadgsvKREDIFYTSK---- 84
Cdd:cd19082   1 SRIVLGTaDFGTRIDEEEAFALLDAFVELGGNFIDTARVYGDWVERGAServigewLKSRG-----NRDKVVIATKgghp 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   85 -LWSNS-HR--PELVRPALERSLKNLQLDYVDLYLIH-----FPVsvkpgEEVIpkdengkilfdtvdlcatwEAMEKCK 155
Cdd:cd19082  76 dLEDMSrSRlsPEDIRADLEESLERLGTDYIDLYFLHrddpsVPV-----GEIV-------------------DTLNELV 131

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  156 DAGLAKSIGVSNFNH-RLLEMI--LNKPGLkYKPVCNQvechPYFN-----------------QRKLLDFCKSKDIVLVA 215
Cdd:cd19082 132 RAGKIRAFGASNWSTeRIAEANayAKAHGL-PGFAASS----PQWSlarpneppwpgptlvamDEEMRAWHEENQLPVFA 206

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  216 YSALG----SHREEPWVDPNSPVL-----------LEdpVLCALAKKHKRTPALIALRYQLQRG--VVVLAKSYNEQRIR 278
Cdd:cd19082 207 YSSQArgffSKRAAGGAEDDSELRrvyyseenferLE--RAKELAEEKGVSPTQIALAYVLNQPfpTVPIIGPRTPEQLR 284


                ....
gi 4503285  279 QNVQ 282
Cdd:cd19082 285 DSLA 288
AKR_Tas-like cd19094
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ...
 31-297 5.62e-16

Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.


Pssm-ID: 381320 [Multi-domain]  Cd Length: 328  Bit Score: 77.22  E-value: 5.62e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   31 KSKALEAVKLAIEAGFHHIDSAHVY-----------------------NNEEQVGLAirSKIADGSvkrEDIFYTSKLWS 87
Cdd:cd19094  17 EAEAHEQLDYAFDEGVNFIDTAEMYpvppspetqgrteeiigswlkkkGNRDKVVLA--TKVAGPG---EGITWPRGGGT 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   88 NsHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKP----GEEVIPKDENgkilfDTVDLCATWEAMEKCKDAGLAKSI 163
Cdd:cd19094  92 R-LDRENIREAVEGSLKRLGTDYIDLYQLHWPDRYTPlfggGYYTEPSEEE-----DSVSFEEQLEALGELVKAGKIRHI 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  164 GVSNFN----HRLLEM--ILNKPglkyKPVCNQvecHPY--FNQRKLLDF---CKSKDIVLVAYSAL------GSHREEP 226
Cdd:cd19094 166 GLSNETpwgvMKFLELaeQLGLP----RIVSIQ---NPYslLNRNFEEGLaeaCHRENVGLLAYSPLaggvltGKYLDGA 238

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  227 WVDPNSPVLL--------EDP-------VLCALAKKHKRTPALIALRYQLQR---GVVVLAKSYNEQrIRQNVQVFEFQL 288
Cdd:cd19094 239 ARPEGGRLNLfpgymaryRSPqaleavaEYVKLARKHGLSPAQLALAWVRSRpfvTSTIIGATTLEQ-LKENIDAFDVPL 317


                ....*....
gi 4503285  289 TSEEMKAID 297
Cdd:cd19094 318 SDELLAEID 326
AKR_AKR12A1_B1_C1 cd19087
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ...
 41-299 8.00e-16

AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.


Pssm-ID: 381313 [Multi-domain]  Cd Length: 310  Bit Score: 76.46  E-value: 8.00e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   41 AIEAGFHHIDSAHVYNN---EEQVGLAIRSKiadgsvkREDIFYTSKLW------------SNSHrpelVRPALERSLKN 105
Cdd:cd19087  39 ALDAGINFFDTADVYGGgrsEEIIGRWIAGR-------RDDIVLATKVFgpmgddpndrglSRRH----IRRAVEASLRR 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  106 LQLDYVDLYLIHFPVSVKPGEEvipkdengkilfdtvdlcaTWEAMEKCKDAGLAKSIGVSNF-------------NHRL 172
Cdd:cd19087 108 LQTDYIDLYQMHHFDRDTPLEE-------------------TLRALDDLVRQGKIRYIGVSNFaawqiakaqgiaaRRGL 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  173 LEMILNKPglKYKPVCNQVEchpyfnqRKLLDFCKSKDIVLVAYSALG---------------SHR--------EEPWVD 229
Cdd:cd19087 169 LRFVSEQP--MYNLLKRQAE-------LEILPAARAYGLGVIPYSPLAgglltgkygkgkrpeSGRlveraryqARYGLE 239

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4503285  230 PNSPVLLEdpvLCALAKKHKRTPALIALRYQLQRGVV--VLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGL 299
Cdd:cd19087 240 EYRDIAER---FEALAAEAGLTPASLALAWVLSHPAVtsPIIGPRTLEQLEDSLAALEITLTPELLAEIDEL 308
AKR_unchar cd19097
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 29-259 2.60e-15

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381323 [Multi-domain]  Cd Length: 267  Bit Score: 74.49  E-value: 2.60e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   29 VPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVglairskIADGSVKREDIFYTSKL----WSNSHRPELVRPALERSLK 104
Cdd:cd19097  23 PSEKEAKKILEYALKAGINTLDTAPAYGDSEKV-------LGKFLKRLDKFKIITKLpplkEDKKEDEAAIEASVEASLK 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  105 NLQLDYVDLYLIHfpvsvkpGEEVIPKDeNGKIlfdtvdlcatWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKY 184
Cdd:cd19097  96 RLKVDSLDGLLLH-------NPDDLLKH-GGKL----------VEALLELKKEGLIRKIGVSVYSPEELEKALESFKIDI 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  185 kpVcnQVechPY--FNQR----KLLDFCKSKDIVLVAYSA-----LGSHREEP--WVDPNSPVLLEdpvLCALAKKHKRT 251
Cdd:cd19097 158 --I--QL---PFniLDQRflksGLLAKLKKKGIEIHARSVflqglLLMEPDKLpaKFAPAKPLLKK---LHELAKKLGLS 227


                ....*...
gi 4503285  252 PALIALRY 259
Cdd:cd19097 228 PLELALGF 235
AKR_AKR9A_9B cd19080
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ...
 42-297 8.86e-15

AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.


Pssm-ID: 381306 [Multi-domain]  Cd Length: 307  Bit Score: 73.41  E-value: 8.86e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   42 IEAGFHHIDSAHVYNN---EEQVGLAIRSKiadgsvkREDIFYTSKLWSN----------SHRPELVRpALERSLKNLQL 108
Cdd:cd19080  41 VEAGGNFIDTANNYTNgtsERLLGEFIAGN-------RDRIVLATKYTMNrrpgdpnaggNHRKNLRR-SVEASLRRLQT 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  109 DYVDLYLIHFPVSVKPGEEVIPK-DE---NGKILFdtVDLCAT--WEAmekCKDAGLAKSIGVSNF-----NHRLLEmil 177
Cdd:cd19080 113 DYIDLLYVHAWDFTTPVEEVMRAlDDlvrAGKVLY--VGISDTpaWVV---ARANTLAELRGWSPFvalqiEYSLLE--- 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  178 nkpglkykpvcNQVEchpyfnqRKLLDFCKSKDIVLVAYSALG-------------SHREEPWVDPNSPVLLED------ 238
Cdd:cd19080 185 -----------RTPE-------RELLPMARALGLGVTPWSPLGgglltgkyqrgeeGRAGEAKGVTVGFGKLTErnwaiv 246

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4503285  239 PVLCALAKKHKRTPALIALRYQLQR---GVVVLAKSYNEQrIRQNVQVFEFQLTSEEMKAID 297
Cdd:cd19080 247 DVVAAVAEELGRSAAQVALAWVRQKpgvVIPIIGARTLEQ-LKDNLGALDLTLSPEQLARLD 307
AKR_AKR7A1-5 cd19075
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ...
 18-299 2.97e-14

AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.


Pssm-ID: 381301 [Multi-domain]  Cd Length: 304  Bit Score: 71.82  E-value: 2.97e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   18 VLG---FGTYA-PAEVPKSKALeaVKLAIEAGFHHIDSAHVYNN---EEQVGlAIRSKIADGSV--KredifyTSKLWSN 88
Cdd:cd19075   4 ILGtmtFGSQGrFTTAEAAAEL--LDAFLERGHTEIDTARVYPDgtsEELLG-ELGLGERGFKIdtK------ANPGVGG 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   89 SHRPELVRPALERSLKNLQLDYVDLYLIHFPvsvkpgeevipkDEngkilfdTVDLCATWEAMEKCKDAGLAKSIGVSNF 168
Cdd:cd19075  75 GLSPENVRKQLETSLKRLKVDKVDVFYLHAP------------DR-------STPLEETLAAIDELYKEGKFKEFGLSNY 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  169 NHRLLEMILN--------KP----GLkYKPVCNQVEchpyfnqRKLLDFCKSKDIVLVAYSAL------GSHREEPWV-- 228
Cdd:cd19075 136 SAWEVAEIVEickengwvLPtvyqGM-YNAITRQVE-------TELFPCLRKLGIRFYAYSPLaggfltGKYKYSEDKag 207

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  229 ----DPNSPVL---------------LEdpVLCALAKKHKRTPALIALRY-----QLQRG---VVVLAKSyNEQRIRQNV 281
Cdd:cd19075 208 ggrfDPNNALGklyrdrywkpsyfeaLE--KVEEAAEKEGISLAEAALRWlyhhsALDGEkgdGVILGAS-SLEQLEENL 284

                       330
                ....*....|....*....
gi 4503285  282 Q-VFEFQLTSEEMKAIDGL 299
Cdd:cd19075 285 AaLEKGPLPEEVVKAIDEA 303
AKR_AKR13C1_2 cd19078
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ...
 19-297 5.09e-14

AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.


Pssm-ID: 381304 [Multi-domain]  Cd Length: 301  Bit Score: 71.11  E-value: 5.09e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   19 LGFG----TYAPAEVP-KSKALEAVKLAIEAGFHHIDSAHVY---NNEEQVGLAIRSKiadgsvkREDIFYTSK------ 84
Cdd:cd19078   7 IGLGcmgmSHGYGPPPdKEEMIELIRKAVELGITFFDTAEVYgpyTNEELVGEALKPF-------RDQVVIATKfgfkid 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   85 ------LWSNShRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIpkdengkilfdtvdlcatwEAMEKCKDAG 158
Cdd:cd19078  80 ggkpgpLGLDS-RPEHIRKAVEGSLKRLQTDYIDLYYQHRVDPNVPIEEVA-------------------GTMKELIKEG 139

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  159 LAKSIGVSNFNhrlLEMIlnKPGLKYKPVCN-QVECHPYFN--QRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSP-- 233
Cdd:cd19078 140 KIRHWGLSEAG---VETI--RRAHAVCPVTAvQSEYSMMWRepEKEVLPTLEELGIGFVPFSPLGKGFLTGKIDENTKfd 214

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  234 --------------------VLLEdpVLCALAKKHKRTPALIALRYQLQRG--VVVLAKSYNEQRIRQNVQVFEFQLTSE 291
Cdd:cd19078 215 egddraslprftpealeanqALVD--LLKEFAEEKGATPAQIALAWLLAKKpwIVPIPGTTKLSRLEENIGAADIELTPE 292


                ....*.
gi 4503285  292 EMKAID 297
Cdd:cd19078 293 ELREIE 298
AKR_AKR8A1-2 cd19077
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ...
 20-297 9.06e-12

AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).


Pssm-ID: 381303 [Multi-domain]  Cd Length: 302  Bit Score: 64.57  E-value: 9.06e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   20 GFG----TYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVG--LAIRSKIADGSVKREDIFYTSKLWSNSH--- 90
Cdd:cd19077   9 GLGlmglTWRPNPTPDEEAFETMKAALDAGSNLWNGGEFYGPPDPHAnlKLLARFFRKYPEYADKVVLSVKGGLDPDtlr 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   91 ---RPELVRPALERSLKNL-QLDYVDLYlihfpvsvkpgeEVIPKDENgkilfdtVDLCATWEAMEKCKDAGLAKSIGVS 166
Cdd:cd19077  89 pdgSPEAVRKSIENILRALgGTKKIDIF------------EPARVDPN-------VPIEETIKALKELVKEGKIRGIGLS 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  167 NFNHrllEMIlnKPGLKYKPV-CNQVECHPYFN---QRKLLDFCKSKDIVLVAYSALGS-----HREEPWVDPNSPVLLE 237
Cdd:cd19077 150 EVSA---ETI--RRAHAVHPIaAVEVEYSLFSReieENGVLETCAELGIPIIAYSPLGRglltgRIKSLADIPEGDFRRH 224

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4503285  238 DP---------------VLCALAKKHKRTPALIAL---RYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAID 297
Cdd:cd19077 225 LDrfngenfeknlklvdALQELAEKKGCTPAQLALawiLAQSGPKIIPIPGSTTLERVEENLKAANVELTDEELKEIN 302
AKR_AKR13D1 cd19145
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ...
 19-296 5.55e-11

AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.


Pssm-ID: 381371 [Multi-domain]  Cd Length: 304  Bit Score: 62.45  E-value: 5.55e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   19 LGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVY---NNEEQVGLAIRSKIadgsvkREDIFYTSK----LWSNSHR 91
Cdd:cd19145  20 MGLSGDYGAPKPEEEGIALIHHAFNSGVTFLDTSDIYgpnTNEVLLGKALKDGP------REKVQLATKfgihEIGGSGV 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   92 -----PELVRPALERSLKNLQLDYVDLYLIH-----FPVSVKPGE--EVIpkdENGKIlfdtvdlcatweamekcKDAGL 159
Cdd:cd19145  94 evrgdPAYVRAACEASLKRLDVDYIDLYYQHridttVPIEITMGElkKLV---EEGKI-----------------KYIGL 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  160 ----AKSIGVSNFNHRLLEMilnkpGLKYKPVCNQVEchpyfnqRKLLDFCKSKDIVLVAYSALGshREEPWvdpNSPVL 235
Cdd:cd19145 154 seasADTIRRAHAVHPITAV-----QLEWSLWTRDIE-------EEIIPTCRELGIGIVPYSPLG--RGFFA---GKAKL 216

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  236 LEDPV-------------------------LCALAKKHKRTPALIALRYQLQRG--VVVLAKSYNEQRIRQNVQVFEFQL 288
Cdd:cd19145 217 EELLEnsdvrkshprfqgenleknkvlyerVEALAKKKGCTPAQLALAWVLHQGedVVPIPGTTKIKNLNQNIGALSVKL 296


                ....*...
gi 4503285  289 TSEEMKAI 296
Cdd:cd19145 297 TKEDLKEI 304
AKR_unchar cd19752
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 42-282 2.06e-10

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381391 [Multi-domain]  Cd Length: 291  Bit Score: 60.42  E-value: 2.06e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   42 IEAGFHHIDSAHVYN----------NEEQVG--LAIRSKiadgsvkREDIFYTSKL---------WSNSHR---PELVRP 97
Cdd:cd19752  27 VAAGGNFLDTANNYAfwteggvggeSERLIGrwLKDRGN-------RDDVVIATKVgagprdpdgGPESPEglsAETIEQ 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   98 ALERSLKNLQLDYVDLYLIHfpvsvkpgeevipkdengkILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEM-- 175
Cdd:cd19752 100 EIDKSLRRLGTDYIDLYYAH-------------------VDDRDTPLEETLEAFNELVKAGKVRAIGASNFAAWRLERar 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  176 -ILNKPGLKyKPVCNQVEcHPYF---------NQR----KLLDFCKS-KDIVLVAYSAL--GSH------REEPWVDPNS 232
Cdd:cd19752 161 qIARQQGWA-EFSAIQQR-HSYLrprpgadfgVQRivtdELLDYASSrPDLTLLAYSPLlsGAYtrpdrpLPEQYDGPDS 238

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 4503285  233 PVLLEdpVLCALAKKHKRTPALIALRYQLQR--GVV-VLAKSYNEQrIRQNVQ 282
Cdd:cd19752 239 DARLA--VLEEVAGELGATPNQVVLAWLLHRtpAIIpLLGASTVEQ-LEENLA 288
tas PRK10625
putative aldo-keto reductase; Provisional
 18-167 9.10e-10

putative aldo-keto reductase; Provisional


Pssm-ID: 236727 [Multi-domain]  Cd Length: 346  Bit Score: 59.10  E-value: 9.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285    18 VLGFGTYAPAEV-PKSKALEAVKLAIEAGFHHIDSAHVYN----------NEEQVGLAIRSKiadGSvkREDIFYTSKLW 86
Cdd:PRK10625  15 TLGLGTMTFGEQnSEADAHAQLDYAVAQGINLIDVAEMYPvpprpetqglTETYIGNWLAKR---GS--REKLIIASKVS 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285    87 ------SNSHRPEL------VRPALERSLKNLQLDYVDLYLIHFPVSvkpgeeviPKDENGKILFD------TVDLCATW 148
Cdd:PRK10625  90 gpsrnnDKGIRPNQaldrknIREALHDSLKRLQTDYLDLYQVHWPQR--------PTNCFGKLGYSwtdsapAVSLLETL 161

                        170
                 ....*....|....*....
gi 4503285   149 EAMEKCKDAGLAKSIGVSN 167
Cdd:PRK10625 162 DALAEQQRAGKIRYIGVSN 180
AKR_AKR6C1_2 cd19143
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ...
 18-129 4.81e-09

AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.


Pssm-ID: 381369 [Multi-domain]  Cd Length: 319  Bit Score: 56.45  E-value: 4.81e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   18 VLGFG---TYApAEVPKSKALEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRskiaDGSVKREDIFYTSKL-W---- 86
Cdd:cd19143  15 ALSFGswvTFG-NQVDVDEAKECMKAAYDAGVNFFDNAEVYANgqsEEIMGQAIK----ELGWPRSDYVVSTKIfWgggg 89

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 4503285   87 --SNSH---RPELVRpALERSLKNLQLDYVDLYLIHFPVSVKPGEEVI 129
Cdd:cd19143  90 ppPNDRglsRKHIVE-GTKASLKRLQLDYVDLVFCHRPDPATPIEETV 136
AKR_FDH cd19162
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ...
 17-166 1.09e-08

D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.


Pssm-ID: 381388 [Multi-domain]  Cd Length: 290  Bit Score: 55.44  E-value: 1.09e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   17 PVLGFGTYA---PAEVPKSKALEAVKLAIEAGFHHIDSAHVYN---NEEQVGLAIRSKiadgsvKREDIFYTSKL----- 85
Cdd:cd19162   1 PRLGLGAASlgnLARAGEDEAAATLDAAWDAGIRYFDTAPLYGlglSERRLGAALARH------PRAEYVVSTKVgrlle 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   86 -----WSNSHRPEL------VRPALERSLKNLQLDYVDLYLIHFPvsvkpgeevipkDENgkilfDTVDLCATWEAMEKC 154
Cdd:cd19162  75 pgaagRPAGADRRFdfsadgIRRSIEASLERLGLDRLDLVFLHDP------------DRH-----LLQALTDAFPALEEL 137

                       170
                ....*....|..
gi 4503285  155 KDAGLAKSIGVS 166
Cdd:cd19162 138 RAEGVVGAIGVG 149
AKR_AKR14A1_2 cd19089
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ...
 20-266 4.05e-08

AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.


Pssm-ID: 381315 [Multi-domain]  Cd Length: 308  Bit Score: 53.80  E-value: 4.05e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   20 GFGTYAPAEVpkskALEAVKLAIEAGFHHIDSAhvyNN--------EEQVGLAIRSkiaDGSVKREDIFYTSK----LW- 86
Cdd:cd19089  21 NFGDYTSPEE----ARELLRTAFDLGITHFDLA---NNygpppgsaEENFGRILKR---DLRPYRDELVISTKagygMWp 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   87 ----SNSHRPELVRpALERSLKNLQLDYVDLYLIHFPVSVKPGEEvipkdengkilfdtvdlcaTWEAMEKCKDAGLAKS 162
Cdd:cd19089  91 gpygDGGSRKYLLA-SLDQSLKRMGLDYVDIFYHHRYDPDTPLEE-------------------TMTALADAVRSGKALY 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  163 IGVSNFN----HRLLEmILNKpgLKYKPVCNQVechPY--FNQ---RKLLDFCKSKDIVLVAYSAL-------------- 219
Cdd:cd19089 151 VGISNYPgakaRRAIA-LLRE--LGVPLIIHQP---RYslLDRwaeDGLLEVLEEAGIGFIAFSPLaqglltdkylngip 224

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 4503285  220 -GSHREEPWVDPNSPVLLEDPV-----LCALAKKHKRTPALIALRYQLQRGVV 266
Cdd:cd19089 225 pDSRRAAESKFLTEEALTPEKLeqlrkLNKIAAKRGQSLAQLALSWVLRDPRV 277
AKR_AKR15A cd19152
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum ...
 17-165 5.54e-08

AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH), and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH(EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.


Pssm-ID: 381378 [Multi-domain]  Cd Length: 308  Bit Score: 53.38  E-value: 5.54e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   17 PVLGFGTyAP-----AEVPKSKALEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRSKiadgsvKREDIFYTSKL--- 85
Cdd:cd19152   1 PKLGFGT-APlgnlyEAVSDEEAKATLVAAWDLGIRYFDTAPWYGAglsEERLGAALREL------GREDYVISTKVgrl 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   86 ---------------WSNS-HRPEL------VRPALERSLKNLQLDYVDLYLIHFPvsvkpgEEVIPKDENgKILFDTVD 143
Cdd:cd19152  74 lvplqeveptfepgfWNPLpFDAVFdysydgILRSIEDSLQRLGLSRIDLLSIHDP------DEDLAGAES-DEHFAQAI 146

                       170       180
                ....*....|....*....|..
gi 4503285  144 LCAtWEAMEKCKDAGLAKSIGV 165
Cdd:cd19152 147 KGA-FRALEELREEGVIKAIGL 167
AKR_AKR6B1 cd19142
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ...
 17-152 5.62e-08

AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.


Pssm-ID: 381368 [Multi-domain]  Cd Length: 325  Bit Score: 53.62  E-value: 5.62e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   17 PVLGFGTYA--PAEVPKSKALEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRSKiadgSVKREDIFYTSKL-WSNsh 90
Cdd:cd19142  14 SNVGLGTWStfSTAISEEQAEEIVTLAYENGINYFDTSDAFTSgqaETELGRILKKK----GWKRSSYIVSTKIyWSY-- 87

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4503285   91 RPE---LVRP----ALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKD----ENGKILFDTvdlCATWEAME 152
Cdd:cd19142  88 GSEergLSRKhiieSVRASLRRLQLDYIDIVIIHKADPMCPMEEVVRAMsyliDNGLIMYWG---TSRWSPVE 157
AKR_ARA2 cd19164
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ...
 18-285 2.24e-07

D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).


Pssm-ID: 381390 [Multi-domain]  Cd Length: 298  Bit Score: 51.51  E-value: 2.24e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   18 VLGFGTYAPA---EVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQV-GLAIrSKIADgSVKREDIFYTSK-----LWSN 88
Cdd:cd19164  17 IFGAATFSYQyttDPESIPPVDIVRRALELGIRAFDTSPYYGPSEIIlGRAL-KALRD-EFPRDTYFIITKvgrygPDDF 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   89 SHRPELVRPALERSLKNLQLDYVDLYLIHfPVSVKPGEEVIpkdENGKILFdtvdlcatweameKCKDAGLAKSIGVSNF 168
Cdd:cd19164  95 DYSPEWIRASVERSLRRLHTDYLDLVYLH-DVEFVADEEVL---EALKELF-------------KLKDEGKIRNVGISGY 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  169 N----HRLLEMILNKPG------LKYKPVCNQVECHPYFNQRKlldFCKSKDIVLVAYSALG----SHREEPWVDPNSPV 234
Cdd:cd19164 158 PlpvlLRLAELARTTAGrpldavLSYCHYTLQNTTLLAYIPKF---LAAAGVKVVLNASPLSmgllRSQGPPEWHPASPE 234

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 4503285  235 LLEDPV-LCALAKKHKRTPALIALRYQLQ----RGVVVLAKSyNEQRIRQNVQVFE 285
Cdd:cd19164 235 LRAAAAkAAEYCQAKGTDLADVALRYALRewggEGPTVVGCS-NVDELEEAVEAYW 289
AKR_galDH-like cd19153
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ...
 20-285 1.32e-06

L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).


Pssm-ID: 381379 [Multi-domain]  Cd Length: 294  Bit Score: 49.07  E-value: 1.32e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   20 GFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRSKiadgSVKREDIFYTSKL-----WSNSHR 91
Cdd:cd19153  21 ALGGVYGDGLEQDEAVAIVAEAFAAGINHFDTSPYYGAessEAVLGKALAAL----QVPRSSYTVATKVgryrdSEFDYS 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   92 PELVRPALERSLKNLQLDYVDLYLIH-------FPVSvkpgEEVIPkdengkilfdtvdlcatweAMEKCKDAGLAKSIG 164
Cdd:cd19153  97 AERVRASVATSLERLHTTYLDVVYLHdiefvdyDTLV----DEALP-------------------ALRTLKDEGVIKRIG 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  165 VSNFNHRLLEMILNK--PGlkyKPVCNQVECHPYFNQRKLLD----FCKSKDIVLVAYSALG----SHREEPWVDPNSPV 234
Cdd:cd19153 154 IAGYPLDTLTRATRRcsPG---SLDAVLSYCHLTLQDARLESdapgLVRGAGPHVINASPLSmgllTSQGPPPWHPASGE 230

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  235 LLEdpvLCALAKKH-----KRTPALiALRYQL----QRGVVVLAKSYNEQrIRQNVQVFE 285
Cdd:cd19153 231 LRH---YAAAADAVcasveASLPDL-ALQYSLaahaGVGTVLLGPSSLAQ-LRSMLAAVD 285
PLN02587 PLN02587
L-galactose dehydrogenase
 18-281 1.39e-06

L-galactose dehydrogenase


Pssm-ID: 178198 [Multi-domain]  Cd Length: 314  Bit Score: 49.01  E-value: 1.39e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285    18 VLGFGTyAP-----AEVPKSKALEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRSKiadgSVKREDIFYTSKLWSNS 89
Cdd:PLN02587  13 SVGFGA-SPlgsvfGPVSEEDAIASVREAFRLGINFFDTSPYYGGtlsEKVLGKALKAL----GIPREKYVVSTKCGRYG 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285    90 H----RPELVRPALERSLKNLQLDYVDLYLIHfpvsvkpgeevipkdengKILFDTVD--LCATWEAMEKCKDAGLAKSI 163
Cdd:PLN02587  88 EgfdfSAERVTKSVDESLARLQLDYVDILHCH------------------DIEFGSLDqiVNETIPALQKLKESGKVRFI 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   164 GVSNFNHRLLEMILNK--PG-----LKYkpvcnqveCHPYFNQRKLLD---FCKSKDIVLVAYSALG----SHREEPWVD 229
Cdd:PLN02587 150 GITGLPLAIFTYVLDRvpPGtvdviLSY--------CHYSLNDSSLEDllpYLKSKGVGVISASPLAmgllTENGPPEWH 221

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 4503285   230 PNSPVLLEdpvLCALAKKH----KRTPALIALRYQL--QRGVVVLAKSYNEQRIRQNV 281
Cdd:PLN02587 222 PAPPELKS---ACAAAATHckekGKNISKLALQYSLsnKDISTTLVGMNSVQQVEENV 276
Aldo_ket_red_shaker cd19141
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family ...
 18-202 4.60e-06

Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.


Pssm-ID: 381367 [Multi-domain]  Cd Length: 310  Bit Score: 47.44  E-value: 4.60e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   18 VLGFGTYAP--AEVPKSKALEAVKLAIEAGFHHIDSAHVY---NNEEQVGLAIRSKiadgSVKREDIFYTSKL-WSNSHR 91
Cdd:cd19141  14 CLGLGTWVTfgSQISDEVAEELVTLAYENGINLFDTAEVYaagKAEIVLGKILKKK----GWRRSSYVITTKIfWGGKAE 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   92 PE--LVRP----ALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPK----DENGKILFDTVdlcATWEAMEKCKDAGLAK 161
Cdd:cd19141  90 TErgLSRKhiieGLKASLERLQLEYVDIVFANRPDPNTPMEEIVRAfthvINQGMAMYWGT---SRWSAMEIMEAYSVAR 166

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 4503285  162 sigvsNFNhrlleMIlnkpglkyKPVCNQVECHpYFNQRKL 202
Cdd:cd19141 167 -----QFN-----LI--------PPIVEQAEYH-LFQREKV 188
AKR_KCAB1B_AKR6A3-like cd19159
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo ...
 19-202 7.45e-06

voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo sapiens, Mus musculus, Mustela putorius, Rattus norvegicus, and Kvb1.1, Kvb1.2 from Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A3 (AKR6A3), A8 (AKR6A8), A10a (AKR6A10a), A13 (AKR6A13), A7 (AKR6A7) and A10b (AKR6A10b), respectively. KCAB1B, also called Shaker channel b-subunit 1(Kvb1), K(+) channel subunit beta-1, or Kv-beta-1, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It modulates action potentials via its effect on the pore-forming alpha subunits.


Pssm-ID: 381385 [Multi-domain]  Cd Length: 323  Bit Score: 46.96  E-value: 7.45e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   19 LGFGTYAP--AEVPKSKALEAVKLAIEAGFHHIDSAHVY---NNEEQVGLAIRSKiadgSVKREDIFYTSKL-WSNSHRP 92
Cdd:cd19159  16 LGLGTWVTfgGQISDEVAERLMTIAYESGVNLFDTAEVYaagKAEVILGSIIKKK----GWRRSSLVITTKLyWGGKAET 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   93 E--LVRP----ALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPK-----DENGKILFDTvdlcATWEAMEKCKDAGLAK 161
Cdd:cd19159  92 ErgLSRKhiieGLKGSLQRLQLEYVDVVFANRPDSNTPMEEIVRAmthviNQGMAMYWGT----SRWSAMEIMEAYSVAR 167

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 4503285  162 sigvsNFNhrlleMIlnkpglkyKPVCNQVECHpYFNQRKL 202
Cdd:cd19159 168 -----QFN-----MI--------PPVCEQAEYH-LFQREKV 189
PRK09912 PRK09912
L-glyceraldehyde 3-phosphate reductase; Provisional
 41-297 1.07e-05

L-glyceraldehyde 3-phosphate reductase; Provisional


Pssm-ID: 182140 [Multi-domain]  Cd Length: 346  Bit Score: 46.52  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285    41 AIEAGFHHIDSAHVY-----NNEEQVGLAIRSkiaDGSVKREDIFYTSK----LW-----SNSHRPELVrPALERSLKNL 106
Cdd:PRK09912  52 AFDLGITHFDLANNYgpppgSAEENFGRLLRE---DFAAYRDELIISTKagydMWpgpygSGGSRKYLL-ASLDQSLKRM 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   107 QLDYVDLYLIHFPVSVKPGEEvipkdengkilfdtvdlcaTWEAMEKCKDAGLAKSIGVSNFN----HRLLEMI--LNKP 180
Cdd:PRK09912 128 GLEYVDIFYSHRVDENTPMEE-------------------TASALAHAVQSGKALYVGISSYSpertQKMVELLreWKIP 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   181 GLKYKPVCNQVecHPYFNQRKLLDFCKSKDIVLVAYSALGS-----------------HREEPWVDPNSPVLLEDP---- 239
Cdd:PRK09912 189 LLIHQPSYNLL--NRWVDKSGLLDTLQNNGVGCIAFTPLAQglltgkylngipqdsrmHREGNKVRGLTPKMLTEAnlns 266

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4503285   240 --VLCALAKKHKRTPALIALRYQL--QRGVVVLAKSYNEQRIRQNVQVFE-FQLTSEEMKAID 297
Cdd:PRK09912 267 lrLLNEMAQQRGQSMAQMALSWLLkdERVTSVLIGASRAEQLEENVQALNnLTFSTEELAQID 329
AKR_KCAB3B_AKR6A9-like cd19160
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo ...
 19-202 3.31e-04

voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo sapiens, Rattus norvegicus, and Mus musculus, are founding members of aldo-keto reductase family 6 member A9 (AKR6A9), A12 (AKR6A12), A14 (AKR6A14), respectively. KCAB3B, also called Shaker channel b-subunit 3 (Kvb3), K(+) channel subunit beta-3, or Kv-beta-3, is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. It alters the functional properties of Kv1.5.


Pssm-ID: 381386 [Multi-domain]  Cd Length: 325  Bit Score: 41.89  E-value: 3.31e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   19 LGFGTYAP--AEVPKSKALEAVKLAIEAGFHHIDSAHVY---NNEEQVGLAIRSKiadgSVKREDIFYTSKLW------- 86
Cdd:cd19160  18 LGLGTWVTfgSQISDETAEDLLTVAYEHGVNLFDTAEVYaagKAERTLGNILKSK----GWRRSSYVVTTKIYwggqaet 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   87 ----SNSHRPELVRPALERslknLQLDYVDLYLIHFPVSVKPGEEVIPK-----DENGKILFDTvdlcATWEAMEKCKDA 157
Cdd:cd19160  94 erglSRKHIIEGLRGSLDR----LQLEYVDIVFANRSDPNSPMEEIVRAmtyviNQGMAMYWGT----SRWSAMEIMEAY 165

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 4503285  158 GLAKsigvsNFNhrlleMIlnkpglkyKPVCNQVECHpYFNQRKL 202
Cdd:cd19160 166 SVAR-----QFN-----LI--------PPVCEQAEYH-LFQREKV 191
AKR_AKR14A2 cd19151
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is ...
 32-294 6.48e-04

Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).


Pssm-ID: 381377 [Multi-domain]  Cd Length: 309  Bit Score: 40.85  E-value: 6.48e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   32 SKALeaVKLAIEAGFHHIDSAHVY-----NNEEQVGLAIRSKIADgsvKREDIFYTSK----LWSNSH-----RPELVrP 97
Cdd:cd19151  32 SRAM--LRRAFDLGITHFDLANNYgpppgSAEENFGRILKEDLKP---YRDELIISTKagytMWPGPYgdwgsKKYLI-A 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   98 ALERSLKNLQLDYVDLYLIHFPVSVKPGEEvipkdengkilfdtvdlcaTWEAMEKCKDAGLAKSIGVSNFNH------- 170
Cdd:cd19151 106 SLDQSLKRMGLDYVDIFYHHRPDPETPLEE-------------------TMGALDQIVRQGKALYVGISNYPPeeareaa 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285  171 RLLEMiLNKPGLKYKPVCNQVECHPyfnQRKLLDFCKSKDIVLVAYSALG---------------SHREEPWVDPNSPVL 235
Cdd:cd19151 167 AILKD-LGTPCLIHQPKYSMFNRWV---EEGLLDVLEEEGIGCIAFSPLAqglltdrylngipedSRAAKGSSFLKPEQI 242

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4503285  236 LEDPV-----LCALAKKHKRTPALIALRYQLQRGVV--VLAKSYNEQRIRQNVQ-VFEFQLTSEEMK 294
Cdd:cd19151 243 TEEKLakvrrLNEIAQARGQKLAQMALAWVLRNKRVtsVLIGASKPSQIEDAVGaLDNREFSEEELA 309
AKR_KCAB2B_AKR6A1-like cd19158
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos ...
 19-200 3.75e-03

voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos taurus, Rattus norvegicus, Mus musculus, Homo sapiens, and Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A1 (AKR6A1), A2 (AKR6A2), A4 (AKR6A4), A5 (AKR6A5), and A6 (AKR6A6), respectively. KCAB2B, also called Shaker channel b-subunit 2 (Kvb2), or K(+) channel subunit beta-2, or Kv-beta-2, or Kvbeta2, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It may be involved in the regulation of nerve signaling, and prevents neuronal hyperexcitability.


Pssm-ID: 381384 [Multi-domain]  Cd Length: 324  Bit Score: 38.53  E-value: 3.75e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   19 LGFGTYAP--AEVPKSKALEAVKLAIEAGFHHIDSAHVY---NNEEQVGLAIRSKiadgSVKREDIFYTSKL-WSNSHRP 92
Cdd:cd19158  16 LGLGTWVTfgGQITDEMAEHLMTLAYDNGINLFDTAEVYaagKAEVVLGNIIKKK----GWRRSSLVITTKIfWGGKAET 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   93 E--LVRP----ALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPK-----DENGKILFDTvdlcATWEAMEKCKDAGLAK 161
Cdd:cd19158  92 ErgLSRKhiieGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAmthviNQGMAMYWGT----SRWSSMEIMEAYSVAR 167

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 4503285  162 SIGVSnfnhrllemilnkpglkyKPVCNQVECHPYFNQR 200
Cdd:cd19158 168 QFNLI------------------PPICEQAEYHMFQREK 188
AKR_AKR9A1-2 cd19146
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus ...
 23-118 5.22e-03

Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and similar proteins; Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV and Aspergillus flavus norsolorinic acid reductase (NOR), are founding members of aldo-keto reductase family 9 member A1-2 (AKR9A1-2), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis.


Pssm-ID: 381372 [Multi-domain]  Cd Length: 326  Bit Score: 38.17  E-value: 5.22e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503285   23 TYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ---VG-----------LAIRSKIADGSVKREDIFYTSKLWSN 88
Cdd:cd19146  26 KSMMGECDKETAFKLLDAFYEQGGNFIDTANNYQGEESerwVGewmasrgnrdeMVLATKYTTGYRRGGPIKIKSNYQGN 105

                        90       100       110
                ....*....|....*....|....*....|
gi 4503285   89 sHRPELvRPALERSLKNLQLDYVDLYLIHF 118
Cdd:cd19146 106 -HAKSL-RLSVEASLKKLQTSYIDILYVHW 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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