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Conserved domains on  [gi|1269208372|ref|NP_001344154|]
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pyridoxal-dependent decarboxylase domain-containing protein 1 isoform 5 [Mus musculus]

Protein Classification

pyridoxal phosphate-dependent decarboxylase family protein( domain architecture ID 1903557)

pyridoxal phosphate-dependent decarboxylase family protein is primarily involved in the biosynthesis of amino acids and amino acid-derived metabolites, but it is also found in the biosynthetic pathways of amino sugars and in the synthesis or catabolism of neurotransmitters

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GadA super family cl43018
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ...
 171-478 6.86e-27

Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


The actual alignment was detected with superfamily member COG0076:

Pssm-ID: 439846 [Multi-domain]  Cd Length: 460  Bit Score: 114.93  E-value: 6.86e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208372 171 KKPVIYLSAAArpglgQY----LCNQLGLPFPCLCRVPCNtmfgSQHQMDVAFLEKLIKDDVERGRLPLLLVANAGTAAV 246
Cdd:COG0076   163 PRPRIVVSEEA-----HSsvdkAARLLGLGRDALRKVPVD----EDGRMDPDALEAAIDEDRAAGLNPIAVVATAGTTNT 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208372 247 GHTDKIGRLKELCEQYGIWLHVEGvnlatlALGyvsSSVLAATK----------CDSMTLTPGLWLGLPAVPAVTLYKHD 316
Cdd:COG0076   234 GAIDPLAEIADIAREHGLWLHVDA------AYG---GFALPSPElrhlldgierADSITVDPHKWLYVPYGCGAVLVRDP 304

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208372 317 D---PALTLVA----------------GLTSNKPAdklRALPLWLSLQYLGLDGIVERIKHACHLSQRLQESLKKVDHIK 377
Cdd:COG0076   305 EllrEAFSFHAsylgpaddgvpnlgdyTLELSRRF---RALKLWATLRALGREGYRELIERCIDLARYLAEGIAALPGFE 381

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208372 378 ILVEDELSspVVVFRFfqelpasdsafkavpvsniAPAAVGRErhscDALNRWLGEQLKQL-VPQCGLTVIDlevDGTCV 456
Cdd:COG0076   382 LLAPPELN--IVCFRY-------------------KPAGLDEE----DALNYALRDRLRARgRAFLSPTKLD---GRVVL 433

                         330       340
                  ....*....|....*....|....*
gi 1269208372 457 RFS---PLmtaeglgTRGEDVDQLI 478
Cdd:COG0076   434 RLVvlnPR-------TTEDDVDALL 451
 
Name Accession Description Interval E-value
GadA COG0076
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ...
 171-478 6.86e-27

Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 439846 [Multi-domain]  Cd Length: 460  Bit Score: 114.93  E-value: 6.86e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208372 171 KKPVIYLSAAArpglgQY----LCNQLGLPFPCLCRVPCNtmfgSQHQMDVAFLEKLIKDDVERGRLPLLLVANAGTAAV 246
Cdd:COG0076   163 PRPRIVVSEEA-----HSsvdkAARLLGLGRDALRKVPVD----EDGRMDPDALEAAIDEDRAAGLNPIAVVATAGTTNT 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208372 247 GHTDKIGRLKELCEQYGIWLHVEGvnlatlALGyvsSSVLAATK----------CDSMTLTPGLWLGLPAVPAVTLYKHD 316
Cdd:COG0076   234 GAIDPLAEIADIAREHGLWLHVDA------AYG---GFALPSPElrhlldgierADSITVDPHKWLYVPYGCGAVLVRDP 304

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208372 317 D---PALTLVA----------------GLTSNKPAdklRALPLWLSLQYLGLDGIVERIKHACHLSQRLQESLKKVDHIK 377
Cdd:COG0076   305 EllrEAFSFHAsylgpaddgvpnlgdyTLELSRRF---RALKLWATLRALGREGYRELIERCIDLARYLAEGIAALPGFE 381

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208372 378 ILVEDELSspVVVFRFfqelpasdsafkavpvsniAPAAVGRErhscDALNRWLGEQLKQL-VPQCGLTVIDlevDGTCV 456
Cdd:COG0076   382 LLAPPELN--IVCFRY-------------------KPAGLDEE----DALNYALRDRLRARgRAFLSPTKLD---GRVVL 433

                         330       340
                  ....*....|....*....|....*
gi 1269208372 457 RFS---PLmtaeglgTRGEDVDQLI 478
Cdd:COG0076   434 RLVvlnPR-------TTEDDVDALL 451
DOPA_deC_like cd06450
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
 171-393 9.53e-21

DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.


Pssm-ID: 99743 [Multi-domain]  Cd Length: 345  Bit Score: 94.58  E-value: 9.53e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208372 171 KKPVIYLSAAARPGL---GQYLCNQLglpfpclCRVPCNtmfgSQHQMDVAFLEKLIKDDVERGRLPLLLVANAGTAAVG 247
Cdd:cd06450    94 DKLVIVCSDQAHVSVekaAAYLDVKV-------RLVPVD----EDGRMDPEALEAAIDEDKAEGLNPIMVVATAGTTDTG 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208372 248 HTDKIGRLKELCEQYGIWLHVEGvnlatlALGyvsSSVLAATK----------CDSMTLTPGLWLGLPAVPAVTLYkhdd 317
Cdd:cd06450   163 AIDPLEEIADLAEKYDLWLHVDA------AYG---GFLLPFPEprhldfgierVDSISVDPHKYGLVPLGCSAVLV---- 229

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1269208372 318 paltlvagltsnkpadklRALPLWLSLQYLGLDGIVERIKHACHLSQRLQESLKKVDHIKILVEDELssPVVVFRF 393
Cdd:cd06450   230 ------------------RALKLWATLRRFGRDGYGEHIDRIVDLAKYLAELIRADPGFELLGEPNL--SLVCFRL 285
Pyridoxal_deC pfam00282
Pyridoxal-dependent decarboxylase conserved domain;
170-392 1.12e-10

Pyridoxal-dependent decarboxylase conserved domain;


Pssm-ID: 395219  Cd Length: 373  Bit Score: 63.98  E-value: 1.12e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208372 170 NKKPVIYLSAAArpglgQYLCNQLGLPFPCLCR-VPCNtmfgSQHQMDVAFLEKLIKDDVERGRLPLLLVANAGTAAVGH 248
Cdd:pfam00282 143 LAKLVAYTSDQA-----HSSIEKAALYGGVKLReIPSD----DNGKMRGMDLEKAIEEDKENGLIPFFVVATLGTTGSGA 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208372 249 TDKIGRLKELCEQYGIWLHVEGVNLATLALG-YVSSSVLAATKCDSMTLTPGLWLGLPAvPAVTLYKHDDPALTLVAGL- 326
Cdd:pfam00282 214 FDDLQELGDICAKHNLWLHVDAAYGGSAFICpEFRHWLFGIERADSITFNPHKWMLVLL-DCSAVWVKDKEALQQAFQFn 292

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208372 327 -----TSNKPAD----------KLRALPLWLSLQYLGLDGIVERIKHACHLSQRLQESLKKVDHIKILVEDELssPVVVF 391
Cdd:pfam00282 293 plylgHTDSAYDtghkqiplsrRFRILKLWFVIRSLGVEGLQNQIRRHVELAQYLEALIRKDGRFEICAEVGL--GLVCF 370


                  .
gi 1269208372 392 R 392
Cdd:pfam00282 371 R 371
PLN02880 PLN02880
tyrosine decarboxylase
 171-428 3.00e-05

tyrosine decarboxylase


Pssm-ID: 215475 [Multi-domain]  Cd Length: 490  Bit Score: 47.21  E-value: 3.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208372 171 KKPVIYLSAAARPGLgQYLCnQLGLPFPCLCRV---PCNTMFGSQHQMdvafLEKLIKDDVERGRLPLLLVANAGTAAVG 247
Cdd:PLN02880  180 EKLVVYASDQTHSAL-QKAC-QIAGIHPENCRLlktDSSTNYALAPEL----LSEAISTDLSSGLIPFFLCATVGTTSST 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208372 248 HTDKIGRLKELCEQYGIWLHVEGvnlatlalGYVSSSVL---------AATKCDSMTLTPGLWLgLPAVPAVTLYKHDDP 318
Cdd:PLN02880  254 AVDPLLELGKIAKSNGMWFHVDA--------AYAGSACIcpeyrhyidGVEEADSFNMNAHKWF-LTNFDCSLLWVKDRN 324

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208372 319 ALTLVAG----LTSNKPAD----------------KLRALPLWLSLQYLGLDGIVERIKHACHLSQRLQEslkkvdhiki 378
Cdd:PLN02880  325 ALIQSLStnpeFLKNKASQansvvdykdwqiplgrRFRSLKLWMVLRLYGVENLQSYIRNHIKLAKEFEQ---------- 394

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1269208372 379 LVEDELSSPVVVFRFFqelpaSDSAFKAVPVSNIAPAAVGRERHSCDALN 428
Cdd:PLN02880  395 LVAQDSRFEVVTPRIF-----SLVCFRLVPPKNNEDNGNKLNHDLLDAVN 439
 
Name Accession Description Interval E-value
GadA COG0076
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ...
 171-478 6.86e-27

Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 439846 [Multi-domain]  Cd Length: 460  Bit Score: 114.93  E-value: 6.86e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208372 171 KKPVIYLSAAArpglgQY----LCNQLGLPFPCLCRVPCNtmfgSQHQMDVAFLEKLIKDDVERGRLPLLLVANAGTAAV 246
Cdd:COG0076   163 PRPRIVVSEEA-----HSsvdkAARLLGLGRDALRKVPVD----EDGRMDPDALEAAIDEDRAAGLNPIAVVATAGTTNT 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208372 247 GHTDKIGRLKELCEQYGIWLHVEGvnlatlALGyvsSSVLAATK----------CDSMTLTPGLWLGLPAVPAVTLYKHD 316
Cdd:COG0076   234 GAIDPLAEIADIAREHGLWLHVDA------AYG---GFALPSPElrhlldgierADSITVDPHKWLYVPYGCGAVLVRDP 304

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208372 317 D---PALTLVA----------------GLTSNKPAdklRALPLWLSLQYLGLDGIVERIKHACHLSQRLQESLKKVDHIK 377
Cdd:COG0076   305 EllrEAFSFHAsylgpaddgvpnlgdyTLELSRRF---RALKLWATLRALGREGYRELIERCIDLARYLAEGIAALPGFE 381

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208372 378 ILVEDELSspVVVFRFfqelpasdsafkavpvsniAPAAVGRErhscDALNRWLGEQLKQL-VPQCGLTVIDlevDGTCV 456
Cdd:COG0076   382 LLAPPELN--IVCFRY-------------------KPAGLDEE----DALNYALRDRLRARgRAFLSPTKLD---GRVVL 433

                         330       340
                  ....*....|....*....|....*
gi 1269208372 457 RFS---PLmtaeglgTRGEDVDQLI 478
Cdd:COG0076   434 RLVvlnPR-------TTEDDVDALL 451
DOPA_deC_like cd06450
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
 171-393 9.53e-21

DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.


Pssm-ID: 99743 [Multi-domain]  Cd Length: 345  Bit Score: 94.58  E-value: 9.53e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208372 171 KKPVIYLSAAARPGL---GQYLCNQLglpfpclCRVPCNtmfgSQHQMDVAFLEKLIKDDVERGRLPLLLVANAGTAAVG 247
Cdd:cd06450    94 DKLVIVCSDQAHVSVekaAAYLDVKV-------RLVPVD----EDGRMDPEALEAAIDEDKAEGLNPIMVVATAGTTDTG 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208372 248 HTDKIGRLKELCEQYGIWLHVEGvnlatlALGyvsSSVLAATK----------CDSMTLTPGLWLGLPAVPAVTLYkhdd 317
Cdd:cd06450   163 AIDPLEEIADLAEKYDLWLHVDA------AYG---GFLLPFPEprhldfgierVDSISVDPHKYGLVPLGCSAVLV---- 229

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1269208372 318 paltlvagltsnkpadklRALPLWLSLQYLGLDGIVERIKHACHLSQRLQESLKKVDHIKILVEDELssPVVVFRF 393
Cdd:cd06450   230 ------------------RALKLWATLRRFGRDGYGEHIDRIVDLAKYLAELIRADPGFELLGEPNL--SLVCFRL 285
Pyridoxal_deC pfam00282
Pyridoxal-dependent decarboxylase conserved domain;
170-392 1.12e-10

Pyridoxal-dependent decarboxylase conserved domain;


Pssm-ID: 395219  Cd Length: 373  Bit Score: 63.98  E-value: 1.12e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208372 170 NKKPVIYLSAAArpglgQYLCNQLGLPFPCLCR-VPCNtmfgSQHQMDVAFLEKLIKDDVERGRLPLLLVANAGTAAVGH 248
Cdd:pfam00282 143 LAKLVAYTSDQA-----HSSIEKAALYGGVKLReIPSD----DNGKMRGMDLEKAIEEDKENGLIPFFVVATLGTTGSGA 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208372 249 TDKIGRLKELCEQYGIWLHVEGVNLATLALG-YVSSSVLAATKCDSMTLTPGLWLGLPAvPAVTLYKHDDPALTLVAGL- 326
Cdd:pfam00282 214 FDDLQELGDICAKHNLWLHVDAAYGGSAFICpEFRHWLFGIERADSITFNPHKWMLVLL-DCSAVWVKDKEALQQAFQFn 292

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208372 327 -----TSNKPAD----------KLRALPLWLSLQYLGLDGIVERIKHACHLSQRLQESLKKVDHIKILVEDELssPVVVF 391
Cdd:pfam00282 293 plylgHTDSAYDtghkqiplsrRFRILKLWFVIRSLGVEGLQNQIRRHVELAQYLEALIRKDGRFEICAEVGL--GLVCF 370


                  .
gi 1269208372 392 R 392
Cdd:pfam00282 371 R 371
PLN02880 PLN02880
tyrosine decarboxylase
 171-428 3.00e-05

tyrosine decarboxylase


Pssm-ID: 215475 [Multi-domain]  Cd Length: 490  Bit Score: 47.21  E-value: 3.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208372 171 KKPVIYLSAAARPGLgQYLCnQLGLPFPCLCRV---PCNTMFGSQHQMdvafLEKLIKDDVERGRLPLLLVANAGTAAVG 247
Cdd:PLN02880  180 EKLVVYASDQTHSAL-QKAC-QIAGIHPENCRLlktDSSTNYALAPEL----LSEAISTDLSSGLIPFFLCATVGTTSST 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208372 248 HTDKIGRLKELCEQYGIWLHVEGvnlatlalGYVSSSVL---------AATKCDSMTLTPGLWLgLPAVPAVTLYKHDDP 318
Cdd:PLN02880  254 AVDPLLELGKIAKSNGMWFHVDA--------AYAGSACIcpeyrhyidGVEEADSFNMNAHKWF-LTNFDCSLLWVKDRN 324

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208372 319 ALTLVAG----LTSNKPAD----------------KLRALPLWLSLQYLGLDGIVERIKHACHLSQRLQEslkkvdhiki 378
Cdd:PLN02880  325 ALIQSLStnpeFLKNKASQansvvdykdwqiplgrRFRSLKLWMVLRLYGVENLQSYIRNHIKLAKEFEQ---------- 394

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1269208372 379 LVEDELSSPVVVFRFFqelpaSDSAFKAVPVSNIAPAAVGRERHSCDALN 428
Cdd:PLN02880  395 LVAQDSRFEVVTPRIF-----SLVCFRLVPPKNNEDNGNKLNHDLLDAVN 439
PLN02590 PLN02590
probable tyrosine decarboxylase
 220-428 1.19e-04

probable tyrosine decarboxylase


Pssm-ID: 178200 [Multi-domain]  Cd Length: 539  Bit Score: 45.47  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208372 220 LEKLIKDDVERGRLPLLLVANAGTAAVGHTDKIGRLKELCEQYGIWLHVEGVNLATLALGYVSSSVLAATK-CDSMTLTP 298
Cdd:PLN02590  274 LEEAISHDLAKGFIPFFICATVGTTSSAAVDPLVPLGNIAKKYGIWLHVDAAYAGNACICPEYRKFIDGIEnADSFNMNA 353

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208372 299 GLWLgLPAVPAVTLYKHDdpALTLVAGLTSNKP----------------------ADKLRALPLWLSLQYLGLDGIVERI 356
Cdd:PLN02590  354 HKWL-FANQTCSPLWVKD--RYSLIDALKTNPEylefkvskkdtvvnykdwqislSRRFRSLKLWMVLRLYGSENLRNFI 430

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1269208372 357 KHACHLSQRLQESLKKVDHIKilvedelsspVVVFRFFqelpaSDSAFKAVPVSNIAPAAVGRERHSCDALN 428
Cdd:PLN02590  431 RDHVNLAKHFEDYVAQDPSFE----------VVTTRYF-----SLVCFRLAPVDGDEDQCNERNRELLAAVN 487
CsdA COG0520
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];
280-482 6.48e-03

Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];


Pssm-ID: 440286 [Multi-domain]  Cd Length: 396  Bit Score: 39.74  E-value: 6.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208372 280 YVSSSVLAAtkcdsmtLTPgLWLGLPAVPAVTLYKHD--DPALTLVAGlTSNKPAdklrALPLWLSLQYL---GLDGIVE 354
Cdd:COG0520   227 YGKRELLEA-------LPP-FLGGGGMIEWVSFDGTTyaDLPRRFEAG-TPNIAG----AIGLGAAIDYLeaiGMEAIEA 293

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208372 355 RIkhaCHLSQRLQESLKKVDHIKIL--VEDELSSPVVVFRffqelpasdsafkavpVSNIAPAAVG----------RERH 422
Cdd:COG0520   294 RE---RELTAYALEGLAAIPGVRILgpADPEDRSGIVSFN----------------VDGVHPHDVAallddegiavRAGH 354

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1269208372 423 SCDA-LNRWLGeqlkqlvpqcgltvidleVDGtCVRFSPlmtaeGLGTRGEDVDQLITCIQ 482
Cdd:COG0520   355 HCAQpLMRRLG------------------VPG-TVRASF-----HLYNTEEEIDRLVEALK 391
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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