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Conserved domains on  [gi|1269208379|ref|NP_001344124|]
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uncharacterized protein LOC71824 isoform 2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 13-186 1.39e-86

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239867  Cd Length: 192  Bit Score: 263.39  E-value: 1.39e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  13 QDMLSILNEKGAITEGIFRISGNMSACHALKERLDYGKKVNLKKECVLAVASVLKEFLHNIQGSVLTSRLYDIWLDVLDQ 92
Cdd:cd04402    20 LDMLSLLYQKGPSTEGIFRRSANAKACKELKEKLNSGVEVDLKAEPVLLLASVLKDFLRNIPGSLLSSDLYEEWMSALDQ 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  93 ENEEEKLAAVQSLLQRLPYPNVSLLRELFRMLHNIERNSAVNKMTAYSLSVCMAPCILCLPRSCnSGLANDISNEISLVK 172
Cdd:cd04402   100 ENEEEKIAELQRLLDKLPRPNVLLLKHLICVLHNISQNSETNKMDAFNLAVCIAPSLLWPPASS-ELQNEDLKKVTSLVQ 178

                         170
                  ....*....|....
gi 1269208379 173 FLIENSLKIFGEST 186
Cdd:cd04402   179 FLIENCQEIFGEDI 192
RhoGAP super family cl02570
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 293-468 8.00e-61

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


The actual alignment was detected with superfamily member cd04402:

Pssm-ID: 470621  Cd Length: 192  Bit Score: 197.14  E-value: 8.00e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 293 LFGKSLTIICKDGNLPAPVLDMLSIIDAKGPDTERIFRTLAN-KPYLTLREKLDSAEEMNLREESVYIVASVLKEFIRNI 371
Cdd:cd04402     1 LFGQPLSNICEDDNLPKPILDMLSLLYQKGPSTEGIFRRSANaKACKELKEKLNSGVEVDLKAEPVLLLASVLKDFLRNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 372 PGSLLCSNLYGKWLAVLDQEFHDQKISAIQSLLIQMPLPNVLLLRHLLSVLHKIKGRSSITHMTAYALSVRIAPSMLWNP 451
Cdd:cd04402    81 PGSLLSSDLYEEWMSALDQENEEEKIAELQRLLDKLPRPNVLLLKHLICVLHNISQNSETNKMDAFNLAVCIAPSLLWPP 160

                         170
                  ....*....|....*..
gi 1269208379 452 SlSNSGFGNDISQKKRL 468
Cdd:cd04402   161 A-SSELQNEDLKKVTSL 176
 
Name Accession Description Interval E-value
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 13-186 1.39e-86

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 263.39  E-value: 1.39e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  13 QDMLSILNEKGAITEGIFRISGNMSACHALKERLDYGKKVNLKKECVLAVASVLKEFLHNIQGSVLTSRLYDIWLDVLDQ 92
Cdd:cd04402    20 LDMLSLLYQKGPSTEGIFRRSANAKACKELKEKLNSGVEVDLKAEPVLLLASVLKDFLRNIPGSLLSSDLYEEWMSALDQ 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  93 ENEEEKLAAVQSLLQRLPYPNVSLLRELFRMLHNIERNSAVNKMTAYSLSVCMAPCILCLPRSCnSGLANDISNEISLVK 172
Cdd:cd04402   100 ENEEEKIAELQRLLDKLPRPNVLLLKHLICVLHNISQNSETNKMDAFNLAVCIAPSLLWPPASS-ELQNEDLKKVTSLVQ 178

                         170
                  ....*....|....
gi 1269208379 173 FLIENSLKIFGEST 186
Cdd:cd04402   179 FLIENCQEIFGEDI 192
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 293-468 8.00e-61

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 197.14  E-value: 8.00e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 293 LFGKSLTIICKDGNLPAPVLDMLSIIDAKGPDTERIFRTLAN-KPYLTLREKLDSAEEMNLREESVYIVASVLKEFIRNI 371
Cdd:cd04402     1 LFGQPLSNICEDDNLPKPILDMLSLLYQKGPSTEGIFRRSANaKACKELKEKLNSGVEVDLKAEPVLLLASVLKDFLRNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 372 PGSLLCSNLYGKWLAVLDQEFHDQKISAIQSLLIQMPLPNVLLLRHLLSVLHKIKGRSSITHMTAYALSVRIAPSMLWNP 451
Cdd:cd04402    81 PGSLLSSDLYEEWMSALDQENEEEKIAELQRLLDKLPRPNVLLLKHLICVLHNISQNSETNKMDAFNLAVCIAPSLLWPP 160

                         170
                  ....*....|....*..
gi 1269208379 452 SlSNSGFGNDISQKKRL 468
Cdd:cd04402   161 A-SSELQNEDLKKVTSL 176
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 13-150 9.43e-40

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 140.37  E-value: 9.43e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  13 QDMLSILNEKGAITEGIFRISGNMSACHALKERLDYGKKV--NLKKECVLAVASVLKEFLHNIQGSVLTSRLYDIWLDVL 90
Cdd:pfam00620   5 RKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVdlDLEEEDVHVVASLLKLFLRELPEPLLTFELYEEFIEAA 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  91 DQENEEEKLAAVQSLLQRLPYPNVSLLRELFRMLHNIERNSAVNKMTAYSLSVCMAPCIL 150
Cdd:pfam00620  85 KLPDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLL 144
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 13-178 5.67e-35

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 128.15  E-value: 5.67e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379   13 QDMLSILNEKGAITEGIFRISGNMSACHALKERLDYGKKVNLKKEC--VLAVASVLKEFLHNIQGSVLTSRLYDIWLDVL 90
Cdd:smart00324   8 EKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDLSEydVHDVAGLLKLFLRELPEPLITYELYEEFIEAA 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379   91 DQENEEEKLAAVQSLLQRLPYPNVSLLRELFRMLHNIERNSAVNKMTAYSLSVCMAPCILcLPRSCNSGLANDISNEISL 170
Cdd:smart00324  88 KLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLL-RPPDGEVASLKDIRHQNTV 166


                   ....*...
gi 1269208379  171 VKFLIENS 178
Cdd:smart00324 167 IEFLIENA 174
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 308-452 2.59e-29

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 112.25  E-value: 2.59e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 308 PAPVLDMLSIIDAKGPDTERIFRTLANKPYLT-LREKLDSAEEM--NLREESVYIVASVLKEFIRNIPGSLLCSNLYGKW 384
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKeLREAFDRGPDVdlDLEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1269208379 385 LAVLDQEFHDQKISAIQSLLIQMPLPNVLLLRHLLSVLHKIKGRSSITHMTAYALSVRIAPSMLWNPS 452
Cdd:pfam00620  81 IEAAKLPDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 305-451 6.60e-21

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 89.63  E-value: 6.60e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  305 GNLPAPVLDMLSIIDAKGPDTERIFRTLANKPYL-TLREKLDSAEEMNLREE--SVYIVASVLKEFIRNIPGSLLCSNLY 381
Cdd:smart00324   1 KPIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVkELRDAFDSGPDPDLDLSeyDVHDVAGLLKLFLRELPEPLITYELY 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  382 GKWLAVLDQEFHDQKISAIQSLLIQMPLPNVLLLRHLLSVLHKIKGRSSITHMTAYALSVRIAPSMLWNP 451
Cdd:smart00324  81 EEFIEAAKLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPP 150
 
Name Accession Description Interval E-value
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 13-186 1.39e-86

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 263.39  E-value: 1.39e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  13 QDMLSILNEKGAITEGIFRISGNMSACHALKERLDYGKKVNLKKECVLAVASVLKEFLHNIQGSVLTSRLYDIWLDVLDQ 92
Cdd:cd04402    20 LDMLSLLYQKGPSTEGIFRRSANAKACKELKEKLNSGVEVDLKAEPVLLLASVLKDFLRNIPGSLLSSDLYEEWMSALDQ 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  93 ENEEEKLAAVQSLLQRLPYPNVSLLRELFRMLHNIERNSAVNKMTAYSLSVCMAPCILCLPRSCnSGLANDISNEISLVK 172
Cdd:cd04402   100 ENEEEKIAELQRLLDKLPRPNVLLLKHLICVLHNISQNSETNKMDAFNLAVCIAPSLLWPPASS-ELQNEDLKKVTSLVQ 178

                         170
                  ....*....|....
gi 1269208379 173 FLIENSLKIFGEST 186
Cdd:cd04402   179 FLIENCQEIFGEDI 192
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 293-468 8.00e-61

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 197.14  E-value: 8.00e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 293 LFGKSLTIICKDGNLPAPVLDMLSIIDAKGPDTERIFRTLAN-KPYLTLREKLDSAEEMNLREESVYIVASVLKEFIRNI 371
Cdd:cd04402     1 LFGQPLSNICEDDNLPKPILDMLSLLYQKGPSTEGIFRRSANaKACKELKEKLNSGVEVDLKAEPVLLLASVLKDFLRNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 372 PGSLLCSNLYGKWLAVLDQEFHDQKISAIQSLLIQMPLPNVLLLRHLLSVLHKIKGRSSITHMTAYALSVRIAPSMLWNP 451
Cdd:cd04402    81 PGSLLSSDLYEEWMSALDQENEEEKIAELQRLLDKLPRPNVLLLKHLICVLHNISQNSETNKMDAFNLAVCIAPSLLWPP 160

                         170
                  ....*....|....*..
gi 1269208379 452 SlSNSGFGNDISQKKRL 468
Cdd:cd04402   161 A-SSELQNEDLKKVTSL 176
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 13-150 9.43e-40

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 140.37  E-value: 9.43e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  13 QDMLSILNEKGAITEGIFRISGNMSACHALKERLDYGKKV--NLKKECVLAVASVLKEFLHNIQGSVLTSRLYDIWLDVL 90
Cdd:pfam00620   5 RKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVdlDLEEEDVHVVASLLKLFLRELPEPLLTFELYEEFIEAA 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  91 DQENEEEKLAAVQSLLQRLPYPNVSLLRELFRMLHNIERNSAVNKMTAYSLSVCMAPCIL 150
Cdd:pfam00620  85 KLPDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLL 144
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 14-177 1.79e-38

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 137.43  E-value: 1.79e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  14 DMLSILNEKGAITEGIFRISGNMSACHALKERLDYGKKV-NLKKECVLAVASVLKEFLHNIQGSVLTSRLYDIWLDVLDQ 92
Cdd:cd00159     6 KCIEYLEKNGLNTEGIFRVSGSASKIEELKKKFDRGEDIdDLEDYDVHDVASLLKLYLRELPEPLIPFELYDEFIELAKI 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  93 ENEEEKLAAVQSLLQRLPYPNVSLLRELFRMLHNIERNSAVNKMTAYSLSVCMAPCILClPRSCNSGLANDISNEISLVK 172
Cdd:cd00159    86 EDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEVNKMTASNLAIVFAPTLLR-PPDSDDELLEDIKKLNEIVE 164


                  ....*
gi 1269208379 173 FLIEN 177
Cdd:cd00159   165 FLIEN 169
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 13-178 5.67e-35

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 128.15  E-value: 5.67e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379   13 QDMLSILNEKGAITEGIFRISGNMSACHALKERLDYGKKVNLKKEC--VLAVASVLKEFLHNIQGSVLTSRLYDIWLDVL 90
Cdd:smart00324   8 EKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDLSEydVHDVAGLLKLFLRELPEPLITYELYEEFIEAA 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379   91 DQENEEEKLAAVQSLLQRLPYPNVSLLRELFRMLHNIERNSAVNKMTAYSLSVCMAPCILcLPRSCNSGLANDISNEISL 170
Cdd:smart00324  88 KLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLL-RPPDGEVASLKDIRHQNTV 166


                   ....*...
gi 1269208379  171 VKFLIENS 178
Cdd:smart00324 167 IEFLIENA 174
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 308-452 2.59e-29

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 112.25  E-value: 2.59e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 308 PAPVLDMLSIIDAKGPDTERIFRTLANKPYLT-LREKLDSAEEM--NLREESVYIVASVLKEFIRNIPGSLLCSNLYGKW 384
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKeLREAFDRGPDVdlDLEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1269208379 385 LAVLDQEFHDQKISAIQSLLIQMPLPNVLLLRHLLSVLHKIKGRSSITHMTAYALSVRIAPSMLWNPS 452
Cdd:pfam00620  81 IEAAKLPDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 23-150 7.66e-22

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 92.76  E-value: 7.66e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  23 GAITEGIFRISGNMSACHALKERLD---YGKKVNLKKECVLAVASVLKEFLHNIQGSVLTSRLYDIWLDVLDQENEEEKL 99
Cdd:cd04385    30 GLMSEGIYRKNGKNSSVKKLLEAFRkdaRSVQLREGEYTVHDVADVLKRFLRDLPDPLLTSELHAEWIEAAELENKDERI 109

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1269208379 100 AAVQSLLQRLPYPNVSLLRELFRMLHNIERNSAVNKMTAYSLSVCMAPCIL 150
Cdd:cd04385   110 ARYKELIRRLPPINRATLKVLIGHLYRVQKHSDENQMSVHNLALVFGPTLF 160
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 14-182 8.51e-22

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 92.79  E-value: 8.51e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  14 DMLSILNEKGAITEGIFRISGNMSACHALKERLDYGKKVNLKKECVLAVASV-LKEFLHNIQGSVLTSRLYDIWLDVLDQ 92
Cdd:cd04404    29 ETVEYLQAHALTTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQYEDVHLPAViLKTFLRELPEPLLTFDLYDDIVGFLNV 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  93 EnEEEKLAAVQSLLQRLPYPNVSLLRELFRMLHNIERNSAVNKMTAYSLSVCMAPCILcLPRSCNSGLAnDISNEISLVK 172
Cdd:cd04404   109 D-KEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSNLAVVFGPNLL-WAKDASMSLS-AINPINTFTK 185

                         170
                  ....*....|
gi 1269208379 173 FLIENSLKIF 182
Cdd:cd04404   186 FLLDHQDEIF 195
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 17-182 1.77e-21

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 92.13  E-value: 1.77e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  17 SILNEKGAITEGIFRISGNMSACHALKERLDYGK---KVNLKKECVLAVASVLKEFLHNIQGSVLTSRLYDIWLDVLDQE 93
Cdd:cd04386    29 MCLLETGMNEEGLFRVGGGASKLKRLKAALDAGTfslPLDEFYSDPHAVASALKSYLRELPDPLLTYNLYEDWVQAANKP 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  94 NEEEKLAAVQSLLQRLPYPNVSLLRELFRMLHNIERNSAVNKMTAYSLSVCMAPCILCLPRSCNSGLANDISNE--ISLV 171
Cdd:cd04386   109 DEDERLQAIWRILNKLPRENRDNLRYLIKFLSKLAQKSDENKMSPSNIAIVLAPNLLWAKNEGSLAEMAAGTSVhvVAIV 188

                         170
                  ....*....|.
gi 1269208379 172 KFLIENSLKIF 182
Cdd:cd04386   189 ELIISHADWFF 199
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 15-177 2.84e-21

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 90.98  E-value: 2.84e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  15 MLSILNEKGAITEGIFRISGNMSACHALKERLDYGKKVNLKKEC-VLAVASVLKEFLHNIQGSVLTSRLYDIWLDVL-DQ 92
Cdd:cd04393    27 IVEYLEQHGLEQEGLFRVNGNAETVEWLRQRLDSGEEVDLSKEAdVCSAASLLRLFLQELPEGLIPASLQIRLMQLYqDY 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  93 ENEEEKLAAVQSLLQRLPYPNVSLLRELFRMLHNIERNSAVNKMTAYSLSVCMAPCILCLPRSCNSGLANDISNEIsLVK 172
Cdd:cd04393   107 NGEDEFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHHENRMTAENLAAVFGPDVFHVYTDVEDMKEQEICSRI-MAK 185


                  ....*
gi 1269208379 173 fLIEN 177
Cdd:cd04393   186 -LLEN 189
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 305-451 6.60e-21

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 89.63  E-value: 6.60e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  305 GNLPAPVLDMLSIIDAKGPDTERIFRTLANKPYL-TLREKLDSAEEMNLREE--SVYIVASVLKEFIRNIPGSLLCSNLY 381
Cdd:smart00324   1 KPIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVkELRDAFDSGPDPDLDLSeyDVHDVAGLLKLFLRELPEPLITYELY 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  382 GKWLAVLDQEFHDQKISAIQSLLIQMPLPNVLLLRHLLSVLHKIKGRSSITHMTAYALSVRIAPSMLWNP 451
Cdd:smart00324  81 EEFIEAAKLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPP 150
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 15-176 9.52e-21

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 89.42  E-value: 9.52e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  15 MLSILNEKGAITEGIFRISGNMSACHALKERLDYG-KKVNLKKECVLAVASVLKEFLHNIQGSVLTSRLYDIWLDVLDQE 93
Cdd:cd04377    22 LLEHIEMHGLYTEGIYRKSGSANKIKELRQGLDTDpDSVNLEDYPIHVITSVLKQWLRELPEPLMTFELYENFLRAMELE 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  94 NEEEKLAAVQSLLQRLPYPNVSLLRELFRMLHNIERNSAVNKMTAYSLSVCMAPCILCLPRSCNSGLA-NDISNEISLVK 172
Cdd:cd04377   102 EKQERVRALYSVLEQLPRANLNTLERLIFHLVRVALQEEVNRMSANALAIVFAPCILRCPDTADPLQSlQDVSKTTTCVE 181


                  ....
gi 1269208379 173 FLIE 176
Cdd:cd04377   182 TLIK 185
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 21-192 1.35e-20

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 89.83  E-value: 1.35e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  21 EKGAITEGIFRISGNMSACHALKERLDYGKKVNLKKECVLA--VASVLKEFLHNIQGSVLTSRLYDIWLDVLD------- 91
Cdd:cd04392    21 EKNLRVEGLFRKPGNSARQQELRDLLNSGTDLDLESGGFHAhdCATVLKGFLGELPEPLLTHAHYPAHLQIADlcqfdek 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  92 -----QENEEEKLAAVQSLLQRLPYPNVSLLRELFRMLHNIERNSAVNKMTAYSLSVCMAPCILClPRSCNsglANDISN 166
Cdd:cd04392   101 gnktsAPDKERLLEALQLLLLLLPEENRNLLKLILDLLYQTAKHEDKNKMSADNLALLFTPHLIC-PRNLT---PEDLHE 176

                         170       180       190
                  ....*....|....*....|....*....|
gi 1269208379 167 EI----SLVKFLIENSLKIFGESTVLRYDA 192
Cdd:cd04392   177 NAqklnSIVTFMIKHSQKLFKAPAYLREDA 206
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 27-182 5.88e-19

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 84.76  E-value: 5.88e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  27 EGIFRISGNMSACHALKERLD--YGKKVNLKKEC----VLAVASVLKEFLHNIQGSVLTSRLYDIWLDVLDQENEEEKLA 100
Cdd:cd04398    35 EGIYRLSGNVSRVNKLKELFDkdPLNVLLISPEDyesdIHSVASLLKLFFRELPEPLLTKALSREFIEAAKIEDESRRRD 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 101 AVQSLLQRLPYPNVSLLRELFRMLHNIERNSAVNKMTAYSLSVCMAPCILclprSCNSGLANDISNEISLVKFLIENSLK 180
Cdd:cd04398   115 ALHGLINDLPDANYATLRALMFHLARIKEHESVNRMSVNNLAIIWGPTLM----NAAPDNAADMSFQSRVIETLLDNAYQ 190


                  ..
gi 1269208379 181 IF 182
Cdd:cd04398   191 IF 192
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 308-456 1.04e-18

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 83.12  E-value: 1.04e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 308 PAPVLDMLSIIDAKGPDTERIFRTLANKPYL-TLREKLDSAEE-MNLREESVYIVASVLKEFIRNIPGSLLCSNLYGKWL 385
Cdd:cd00159     1 PLIIEKCIEYLEKNGLNTEGIFRVSGSASKIeELKKKFDRGEDiDDLEDYDVHDVASLLKLYLRELPEPLIPFELYDEFI 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1269208379 386 AVLDQEFHDQKISAIQSLLIQMPLPNVLLLRHLLSVLHKIKGRSSITHMTAYALSVRIAPSMLWNPSLSNS 456
Cdd:cd00159    81 ELAKIEDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEVNKMTASNLAIVFAPTLLRPPDSDDE 151
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 19-182 7.92e-18

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 81.72  E-value: 7.92e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  19 LNEKGAITEGIFRISGNMSACHALKERLDYGKKVNLKKE-CVLAVASVLKEFLHNIQGSVLTSRLYDIWLDVLdQENEEE 97
Cdd:cd04376    20 LEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDENhSVHDVAALLKEFFRDMPDPLLPRELYTAFIGTA-LLEPDE 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  98 KLAAVQSLLQRLPYPNVSLLRELFRMLHNIERNSAV-----------NKMTAYSLSVCMAPCILCLPRSCNSGL------ 160
Cdd:cd04376    99 QLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADsidedgqevsgNKMTSLNLATIFGPNLLHKQKSGEREFvqaslr 178

                         170       180
                  ....*....|....*....|..
gi 1269208379 161 ANDISNEISLVKFLIENSLKIF 182
Cdd:cd04376   179 IEESTAIINVVQTMIDNYEELF 200
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 22-182 1.58e-17

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 80.64  E-value: 1.58e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  22 KGAITEGIFRISGNMSACHALKERLDY-GKKVNLKKEC---VLAVASVLKEFLHNIQGSVLTSRLYDIWLDVLDQENEEE 97
Cdd:cd04372    30 RGLQSEGLYRVSGFAEEIEDVKMAFDRdGEKADISATVypdINVITGALKLYFRDLPIPVITYDTYPKFIDAAKISNPDE 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  98 KLAAVQSLLQRLPYPNVSLLRELFRMLHNIERNSAVNKMTAYSLSVCMAPCILCLPRSCNSGLANDISNEISLVKFLIEN 177
Cdd:cd04372   110 RLEAVHEALMLLPPAHYETLRYLMEHLKRVTLHEKDNKMNAENLGIVFGPTLMRPPEDSALTTLNDMRYQILIVQLLITN 189


                  ....*
gi 1269208379 178 SLKIF 182
Cdd:cd04372   190 EDVLF 194
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 13-175 2.49e-16

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 76.95  E-value: 2.49e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  13 QDMLSILNEKGAITEGIFRISGNMSACHALKERLDYG-KKVNLKKECVLAVASVLKEFLHNIQGSVLTSRLYDIWLDVLD 91
Cdd:cd04407    20 EKLLEHVEMHGLYTEGIYRKSGSANRMKELHQLLQADpENVKLENYPIHAITGLLKQWLRELPEPLMTFAQYNDFLRAVE 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  92 QENEEEKLAAVQSLLQRLPYPNVSLLRELFRMLHNIERNSAVNKMTAYSLSVCMAPCILCLPRSCNSGLA-NDISNEISL 170
Cdd:cd04407   100 LPEKQEQLQAIYRVLEQLPTANHNTLERLIFHLVKVALEEDVNRMSPNALAIVFAPCLLRCPDSSDPLTSmKDVAKTTTC 179


                  ....*
gi 1269208379 171 VKFLI 175
Cdd:cd04407   180 VEMLI 184
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 14-177 5.71e-16

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 76.63  E-value: 5.71e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  14 DMLSILNEKGAITEGIFRISGNMSACHALKERLD--YGKKVNLKKECVLAVASVLKEFLHNIQGSVLTSRLYDIWLDVLD 91
Cdd:cd04397    33 DIISAMRQMDMSVEGVFRKNGNIRRLKELTEEIDknPTEVPDLSKENPVQLAALLKKFLRELPDPLLTFKLYRLWISSQK 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  92 QENEEEKLAAVQSLLQRLPYPNVSLLRELFRML------HNIERNSAvNKMTAYSLSVCMAPCILcLPRSCNSGLANDIS 165
Cdd:cd04397   113 IEDEEERKRVLHLVYCLLPKYHRDTMEVLFSFLkwvssfSHIDEETG-SKMDIHNLATVITPNIL-YSKTDNPNTGDEYF 190

                         170
                  ....*....|..
gi 1269208379 166 NEISLVKFLIEN 177
Cdd:cd04397   191 LAIEAVNYLIEN 202
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 17-182 1.18e-15

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 75.13  E-value: 1.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  17 SILNEKGAITEGIFRISGNMSACHALKERLDYG-KKVNL---KKECVLAVASVLKEFLHNIQGSVLTSRLYDIWLDVLDQ 92
Cdd:cd04395    27 NIVEARGLETVGIYRVPGNNAAISALQEELNRGgFDIDLqdpRWRDVNVVSSLLKSFFRKLPEPLFTNELYPDFIEANRI 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  93 ENEEEKLAAVQSLLQRLPYPNVSLLRELFRMLHNIERNSAVNKMTAYSLSVCMAPCILclpRSCNSGLAN---DISNEIS 169
Cdd:cd04395   107 EDPVERLKELRRLIHSLPDHHYETLKHLIRHLKTVADNSEVNKMEPRNLAIVFGPTLV---RTSDDNMETmvtHMPDQCK 183

                         170
                  ....*....|...
gi 1269208379 170 LVKFLIENSLKIF 182
Cdd:cd04395   184 IVETLIQHYDWFF 196
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 19-181 1.25e-15

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 75.91  E-value: 1.25e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  19 LNEKGAITEGIFRISGNMSACHALKERL----DYGKKVNLKKECVLAVASVLKEFLHNIQGSVLTSRLYDIWLDVLDQEN 94
Cdd:cd04396    43 LKENATEVEGIFRVAGSSKRIRELQLIFstppDYGKSFDWDGYTVHDAASVLRRYLNNLPEPLVPLDLYEEFRNPLRKRP 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  95 --------------EEEKLAAV---QSLLQRLPYPNVSLLRELFRMLHNIERNSAVNKMTAYSLSVCMAPCILCLPRSCN 157
Cdd:cd04396   123 rilqymkgrineplNTDIDQAIkeyRDLITRLPNLNRQLLLYLLDLLAVFARNSDKNLMTASNLAAIFQPGILSHPDHEM 202

                         170       180
                  ....*....|....*....|....
gi 1269208379 158 SGLANDISNeiSLVKFLIENSLKI 181
Cdd:cd04396   203 DPKEYKLSR--LVVEFLIEHQDKF 224
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 13-182 2.72e-15

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 74.69  E-value: 2.72e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  13 QDMLSILNEKGAITEGIFRISGNMSACHALKERLD---YGKKVNLKKECVLAVASVLKEFLHNIQGSVLTSRLYDIWLDV 89
Cdd:cd04391    27 QKLINKLEERGLETEGILRIPGSAQRVKFLCQELEakfYEGTFLWDQVKQHDAASLLKLFIRELPQPLLTVEYLPAFYSV 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  90 LDQENEEEKLAAVQSLLQRLPYPNVSLLRELFRMLHNIERNSAVNKMTAYSLSVCMAPCiLCLPRSCNSGLANDISNEI- 168
Cdd:cd04391   107 QGLPSKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEEKNKMNLWNVAMIMAPN-LFPPRGKHSKDNESLQEEVn 185

                         170       180
                  ....*....|....*....|
gi 1269208379 169 ------SLVKFLIENSLKIF 182
Cdd:cd04391   186 maagcaNIMRLLIRYQDLLW 205
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 21-150 3.00e-15

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 73.96  E-value: 3.00e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  21 EKGAITEGIFRISGNMSACHALKERLDYGKKVNL---KKECVLAVASVLKEFLHNIQGSVLTSRLYDIWLDVLDQENEEE 97
Cdd:cd04403    29 KRGLDVDGIYRVSGNLAVIQKLRFAVDHDEKLDLddsKWEDIHVITGALKLFFRELPEPLFPYSLFNDFVAAIKLSDYEQ 108

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1269208379  98 KLAAVQSLLQRLPYPNVSLLRELFRMLHNIERNSAVNKMTAYSLSVCMAPCIL 150
Cdd:cd04403   109 RVSAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHGEKNRMTTQNLAIVFGPTLL 161
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 10-147 4.88e-15

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 73.16  E-value: 4.88e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  10 STCQDMLSILNEKGAI-TEGIFRISGNMSACHALKERLDYGKKVNLKKEC----VLAVASVLKEFLHNIQGSVLTSRLYD 84
Cdd:cd04400    24 SVVYRCIEYLDKNRAIyEEGIFRLSGSASVIKQLKERFNTEYDVDLFSSSlypdVHTVAGLLKLYLRELPTLILGGELHN 103

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1269208379  85 IWLDVLD-QENEEEKLAAVQSLLQRLPYPNVSLLRELFRMLHNIERNSAVNKMTAYSLSVCMAP 147
Cdd:cd04400   104 DFKRLVEeNHDRSQRALELKDLVSQLPQANYDLLYVLFSFLRKIIEHSDVNKMNLRNVCIVFSP 167
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 11-181 3.11e-14

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 71.35  E-value: 3.11e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  11 TCQDMLSILNekgaiTEGIFRISGNMSACHALKERLDYGKKVnLKKECVLAVASVLKEFLHNIQGSVLTSRLYDIWLDVL 90
Cdd:cd04394    27 ACTFLLDHLS-----TEGLFRKSGSVVRQKELKAKLEGGEAC-LSSALPCDVAGLLKQFFRELPEPLLPYDLHEALLKAQ 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  91 DQENEEEKLAAVQSLLQRLPYPNVSLLRELFRMLHNIERNSAVNKMTAYSLSVCMAPCILclprSCNSGLANDISN---- 166
Cdd:cd04394   101 ELPTDEERKSATLLLTCLLPDEHVNTLRYFFSFLYDVAQRCSENKMDSSNLAVIFAPNLF----QSEEGGEKMSSStekr 176

                         170
                  ....*....|....*...
gi 1269208379 167 ---EISLVKFLIENSLKI 181
Cdd:cd04394   177 lrlQAAVVQTLIDNASNI 194
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 13-175 3.60e-14

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 70.80  E-value: 3.60e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  13 QDMLSILNEKGAITEGIFRISGNMSACHALKERLDY-GKKVNLKKECVLAVASVLKEFLHNIQGSVLTSRLYDIWLDVLD 91
Cdd:cd04406    20 EKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTdANSVNLDDYNIHVIASVFKQWLRDLPNPLMTFELYEEFLRAMG 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  92 QENEEEKLAAVQSLLQRLPYPNVSLLRELFRMLHNIERNSAVNKMTAYSLSVCMAPCILCLPRSCNS-GLANDISNEISL 170
Cdd:cd04406   100 LQERRETVRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEETNRMSANALAIVFAPCILRCPDTTDPlQSVQDISKTTTC 179


                  ....*
gi 1269208379 171 VKFLI 175
Cdd:cd04406   180 VELIV 184
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 28-149 7.77e-14

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 70.52  E-value: 7.77e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  28 GIFRISGNMSACHALKERLD-YGKKVNLKKECVLAVASVLKEFLHNIQGSVLTSRLYDIWLDVLDQENEEEKLAAVQSLL 106
Cdd:cd04375    40 GLFRKSGVKSRIQKLRSMIEsSTDNVNYDGQQAYDVADMLKQYFRDLPEPLLTNKLSETFIAIFQYVPKEQRLEAVQCAI 119

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1269208379 107 QRLPYPNVSLLRELFRMLHNIERNSAVNKMTAYSLSVCMAPCI 149
Cdd:cd04375   120 LLLPDENREVLQTLLYFLSDVAANSQENQMTATNLAVCLAPSL 162
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 18-177 1.02e-13

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 69.34  E-value: 1.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  18 ILNEKGAITEGIFRISGNMSACHALKERLDYGKKVNLKKECVLAVASVLKEFLHNIQGSVLTSRLYDiwlDVLDQENEEE 97
Cdd:cd04389    32 VLALGGFQTEGIFRVPGDIDEVNELKLRVDQWDYPLSGLEDPHVPASLLKLWLRELEEPLIPDALYQ---QCISASEDPD 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  98 KLAAVqslLQRLPYPNVSLLRELFRMLHN--IERNSAVNKMTAYSLSVCMAPCIL-CLPRSCNSGLANdISNEISLVKFL 174
Cdd:cd04389   109 KAVEI---VQKLPIINRLVLCYLINFLQVfaQPENVAHTKMDVSNLAMVFAPNILrCTSDDPRVIFEN-TRKEMSFLRTL 184


                  ...
gi 1269208379 175 IEN 177
Cdd:cd04389   185 IEH 187
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 9-177 6.49e-13

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 67.42  E-value: 6.49e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379   9 FSTCQDMLSILNEKGAITEGIFRISGNMSACHALKERLDYGKK-----VNLKKEC--VLAVASVLKEFLHNIQGSVLTSR 81
Cdd:cd04374    29 FKFVRKCIEAVETRGINEQGLYRVVGVNSKVQKLLSLGLDPKTstpgdVDLDNSEweIKTITSALKTYLRNLPEPLMTYE 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  82 LYDIWLDVLDQENEEEKLAAVQSLLQRLPYPNVSLLRELFRMLHNIERNSAVNKMTAYSLSVCMAPCILclpRSCNSGLA 161
Cdd:cd04374   109 LHNDFINAAKSENLESRVNAIHSLVHKLPEKNREMLELLIKHLTNVSDHSKKNLMTVSNLGVVFGPTLL---RPQEETVA 185

                         170
                  ....*....|....*...
gi 1269208379 162 N--DISNEISLVKFLIEN 177
Cdd:cd04374   186 AimDIKFQNIVVEILIEN 203
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 23-147 8.03e-13

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 66.71  E-value: 8.03e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  23 GAITEGIFRISGNMSACHALKERLDYGKKVNL--KKECVLAVASVLKEFLHNIQGSVLTSRLYDIWLDVLDQENEEEKLA 100
Cdd:cd04373    30 GLETEGIYRVSGNKTHLDSLQKQFDQDHNLDLvsKDFTVNAVAGALKSFFSELPDPLIPYSMHLELVEAAKINDREQRLH 109

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1269208379 101 AVQSLLQRLPYPNVSLLRELFRMLHNIERNSAVNKMTAYSLSVCMAP 147
Cdd:cd04373   110 ALKELLKKFPPENFDVFKYVITHLNKVSQNSKVNLMTSENLSICFWP 156
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 21-150 1.05e-12

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 66.70  E-value: 1.05e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  21 EKGAITEGIFRISGNMSACHALKERLDYGKKVNLKKEC-VLAVASVLKEFLHNIQGSVLTSRLYDIWLD---VLDQEnEE 96
Cdd:cd04390    35 EHGLKEEGLFRLPGQANLVKQLQDAFDAGERPSFDSDTdVHTVASLLKLYLRELPEPVIPWAQYEDFLScaqLLSKD-EE 113

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1269208379  97 EKLAAVQSLLQRLPYPNVSLLRELFRMLHNIERNSAVNKMTAYSLSVCMAPCIL 150
Cdd:cd04390   114 KGLGELMKQVSILPKVNYNLLSYICRFLDEVQSNSSVNKMSVQNLATVFGPNIL 167
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 21-161 3.12e-12

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 65.22  E-value: 3.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  21 EKGAITEGIFRISGNMSACHALKERLDYGKKVNLKKECVL----AVASVLKEFLHNIQGSVLTSRLYDIWLDVLDQENEE 96
Cdd:cd04384    30 EKHGIVDGIYRLSGIASNIQRLRHEFDSEQIPDLTKDVYIqdihSVSSLCKLYFRELPNPLLTYQLYEKFSEAVSAASDE 109

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1269208379  97 EKLAAVQSLLQRLPYPNVSLLRELFRMLHNIERNSAVNKMTAYSLSVCMAPCILCLPR---SCNSGLA 161
Cdd:cd04384   110 ERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSITNMHAKNLAIVWAPNLLRSKQiesACFSGTA 177
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 27-177 5.56e-12

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 64.75  E-value: 5.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  27 EGIFRISGNMSACHALKERLDYGKK-VNLKKECVLAVASVLKEFLHNIQGSVLTSRLYDIWLDV---LDQENEEEK---- 98
Cdd:cd04378    35 QGIYRVSGSKARVEKLCQAFENGKDlVELSELSPHDISSVLKLFLRQLPEPLILFRLYNDFIALakeIQRDTEEDKapnt 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  99 -------LAAVQSLLQRLPYPNVSLLRELFRMLHNIERNSAVNKMTAYSLSVCMAPCILcLPRSCN-----SGLAnDISN 166
Cdd:cd04378   115 pievnriIRKLKDLLRQLPASNYNTLQHLIAHLYRVAEQFEENKMSPNNLGIVFGPTLI-RPRPGDadvslSSLV-DYGY 192

                         170
                  ....*....|.
gi 1269208379 167 EISLVKFLIEN 177
Cdd:cd04378   193 QARLVEFLITN 203
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 292-456 5.96e-12

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 64.67  E-value: 5.96e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 292 HLFGKSLTII---CKD-GNLPAPVLDMLSIIDAKGPDTERIFRTLANKPYLT-LREKLDSAEEMNLR-EESVYIVASVLK 365
Cdd:cd04404     4 QQFGVSLQFLkekNPEqEPIPPVVRETVEYLQAHALTTEGIFRRSANTQVVKeVQQKYNMGEPVDFDqYEDVHLPAVILK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 366 EFIRNIPGSLLCSNLYGKWLAVLDQEfHDQKISAIQSLLIQMPLPNVLLLRHLLSVLHKIKGRSSITHMTAYALSVRIAP 445
Cdd:cd04404    84 TFLRELPEPLLTFDLYDDIVGFLNVD-KEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSNLAVVFGP 162

                         170
                  ....*....|.
gi 1269208379 446 SMLWNPSLSNS 456
Cdd:cd04404   163 NLLWAKDASMS 173
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 294-451 1.60e-11

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 63.23  E-value: 1.60e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 294 FGKSL-TIICKDGNLPAPVLDMLSIIDAKGPDTERIFRTLANKPYL-TLREKLDS-AEEMNLREESVYIVASVLKEFIRN 370
Cdd:cd04377     1 FGVSLsSLTSEDRSVPLVLEKLLEHIEMHGLYTEGIYRKSGSANKIkELRQGLDTdPDSVNLEDYPIHVITSVLKQWLRE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 371 IPGSLLCSNLYGKWLAVLDQEFHDQKISAIQSLLIQMPLPNVLLLRHLLSVLHKIKGRSSITHMTAYALSVRIAPSMLWN 450
Cdd:cd04377    81 LPEPLMTFELYENFLRAMELEEKQERVRALYSVLEQLPRANLNTLERLIFHLVRVALQEEVNRMSANALAIVFAPCILRC 160


                  .
gi 1269208379 451 P 451
Cdd:cd04377   161 P 161
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 19-153 1.92e-11

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 62.82  E-value: 1.92e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  19 LNEKGAITEGIFRISGNMSACHALKERLDYGKK--VNLKKECVL-AVASVLKEFLHNIQGSVLTSRLYDIWLDVLDQENE 95
Cdd:cd04383    29 INLYGLQHQGIFRVSGSQVEVNDIKNAFERGEDplADDQNDHDInSVAGVLKLYFRGLENPLFPKERFEDLMSCVKLENP 108

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1269208379  96 EEKLAAVQSLLQRLPYPNVSLLRELFRMLHNIERNSAVNKMTAYSLSVCMAPCILCLP 153
Cdd:cd04383   109 TERVHQIREILSTLPRSVIIVMRYLFAFLNHLSQFSDENMMDPYNLAICFGPTLMPVP 166
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 27-149 4.33e-11

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 61.93  E-value: 4.33e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  27 EGIFRISGNMSACHALKERLDYGKKV-NLKKECVLAVASVLKEFLHNIQGSVLTSRLYDIWLDVLDQENEEEKLAAVQSL 105
Cdd:cd04382    36 EGLYRVSGSEREVKALKEKFLRGKTVpNLSKVDIHVICGCLKDFLRSLKEPLITFALWKEFMEAAEILDEDNSRAALYQA 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1269208379 106 LQRLPYPNVSLLRelFRMLHnIER--NSAVNKMTAYSLSVCMAPCI 149
Cdd:cd04382   116 ISELPQPNRDTLA--FLILH-LQRvaQSPECKMDINNLARVFGPTI 158
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 294-448 6.27e-11

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 61.25  E-value: 6.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 294 FGKSLTIICKDGNLPAPVLDMLSI--IDAKGPDTERIFRTLANKPYLT-LREKLDSAEEMNL---REESVYIVASVLKEF 367
Cdd:cd04403     1 FGCHLEALCQRENSTVPKFVRLCIeaVEKRGLDVDGIYRVSGNLAVIQkLRFAVDHDEKLDLddsKWEDIHVITGALKLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 368 IRNIPGSLLCSNLYGKWLAVLDQEFHDQKISAIQSLLIQMPLPNVLLLRHLLSVLHKIKGRSSITHMTAYALSVRIAPSM 447
Cdd:cd04403    81 FRELPEPLFPYSLFNDFVAAIKLSDYEQRVSAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHGEKNRMTTQNLAIVFGPTL 160


                  .
gi 1269208379 448 L 448
Cdd:cd04403   161 L 161
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 13-154 1.20e-10

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 60.53  E-value: 1.20e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  13 QDMLSILNEKGAITEGIFRISGNMSACHALKERLDYGKKVNLKKECVLAVASVLKEFLHNIQGSVLTSRLYDIWLDVLDQ 92
Cdd:cd04381    25 RECIDYVEKHGMKCEGIYKVSGIKSKVDELKAAYNRRESPNLEEYEPPTVASLLKQYLRELPEPLLTKELMPRFEEACGR 104

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1269208379  93 ENEEEKLAAVQSLLQRLPYPNVSLLRELFRMLHNIERNSAVNKMTAYSLSVCMAPCILCLPR 154
Cdd:cd04381   105 PTEAEREQELQRLLKELPECNRLLLAWLIVHMDHVIAQELETKMNIQNISIVLSPTVQISNR 166
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 22-170 1.48e-10

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 60.33  E-value: 1.48e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  22 KGAITEGIFRISGNMSACHALKERLDYGKK---VNLKKECVLAVASVLKEFLHNIQGSVLTSRLYDIWLDVLDQENEEEK 98
Cdd:cd04387    30 RGMEEVGIYRISGVATDIQALKAAFDTNNKdvsVMLSEMDVNAIAGTLKLYFRELPEPLFTDELYPNFAEGIALSDPVAK 109

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1269208379  99 LAAVQSLLQRLPYPNVSLLRELFRMLHNIERNSAVNKMTAYSLSVCMAPCILCLPRSCNSGLANDISNEISL 170
Cdd:cd04387   110 ESCMLNLLLSLPDPNLVTFLFLLHHLKRVAEREEVNKMSLHNLATVFGPTLLRPSEKESKIPTNTMTDSWSL 181
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 321-461 5.17e-10

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 59.01  E-value: 5.17e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 321 KGPDTERIFRTLANKPYLT-LREKLDsAEEMNLREESVY----IVASVLKEFIRNIPGSLLCSNLYGKWLAVLDQEFHDQ 395
Cdd:cd04386    34 TGMNEEGLFRVGGGASKLKrLKAALD-AGTFSLPLDEFYsdphAVASALKSYLRELPDPLLTYNLYEDWVQAANKPDEDE 112

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1269208379 396 KISAIQSLLIQMPLPNVLLLRHLLSVLHKIKGRSSITHMTAYALSVRIAPSMLWNPSLSNSGFGND 461
Cdd:cd04386   113 RLQAIWRILNKLPRENRDNLRYLIKFLSKLAQKSDENKMSPSNIAIVLAPNLLWAKNEGSLAEMAA 178
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 354-448 8.38e-10

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 58.09  E-value: 8.38e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 354 EESVYIVASVLKEFIRNIPGSLLCSNLYGKWLAVLDQEFHDQKISAIQSLLIQMPLPNVLLLRHLLSVLHKIKGRSSITH 433
Cdd:cd04385    66 EYTVHDVADVLKRFLRDLPDPLLTSELHAEWIEAAELENKDERIARYKELIRRLPPINRATLKVLIGHLYRVQKHSDENQ 145

                          90
                  ....*....|....*
gi 1269208379 434 MTAYALSVRIAPSML 448
Cdd:cd04385   146 MSVHNLALVFGPTLF 160
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 328-448 1.83e-09

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 57.45  E-value: 1.83e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 328 IFRTLANKPYL-TLREKLDSAEEMNLREE-SVYIVASVLKEFIRNIPGSLLCSNLYGKWLAVLDQEFHDQkISAIQSLLI 405
Cdd:cd04376    30 IFRVGSSKKRVrQLREEFDRGIDVVLDENhSVHDVAALLKEFFRDMPDPLLPRELYTAFIGTALLEPDEQ-LEALQLLIY 108

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1269208379 406 QMPLPNVLLLRHLLSVLHKIKGRSSITH-----------MTAYALSVRIAPSML 448
Cdd:cd04376   109 LLPPCNCDTLHRLLKFLHTVAEHAADSIdedgqevsgnkMTSLNLATIFGPNLL 162
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 294-467 2.32e-09

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 57.03  E-value: 2.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 294 FGKSL-TIICKDG-NLPAPVLDMLSIIDAKGPDTERIFRTLANKPYLT-LREKLD---SAEEMNLREES---VYIVASVL 364
Cdd:cd04398     1 FGVPLeDLILREGdNVPNIVYQCIQAIENFGLNLEGIYRLSGNVSRVNkLKELFDkdpLNVLLISPEDYesdIHSVASLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 365 KEFIRNIPGSLLCSNLYGKWLAVLDQEFHDQKISAIQSLLIQMPLPNVLLLRHLLSVLHKIKGRSSITHMTAYALSVria 444
Cdd:cd04398    81 KLFFRELPEPLLTKALSREFIEAAKIEDESRRRDALHGLINDLPDANYATLRALMFHLARIKEHESVNRMSVNNLAI--- 157

                         170       180
                  ....*....|....*....|....*
gi 1269208379 445 psmLWNPSLSNSGFGN--DISQKKR 467
Cdd:cd04398   158 ---IWGPTLMNAAPDNaaDMSFQSR 179
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 340-461 2.35e-09

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 56.74  E-value: 2.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 340 LREKLDSAEEMNLREES----VYIVASVLKEFIRNIPGSLLCSNLYGKWLAVLDQEFHDQKISAIQSLLIQMPLPNVLLL 415
Cdd:cd04384    51 LRHEFDSEQIPDLTKDVyiqdIHSVSSLCKLYFRELPNPLLTYQLYEKFSEAVSAASDEERLEKIHDVIQQLPPPHYRTL 130

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1269208379 416 RHLLSVLHKIKGRSSITHMTAYALSVRIAPSMLWNPSLSNSGFGND 461
Cdd:cd04384   131 EFLMRHLSRLAKYCSITNMHAKNLAIVWAPNLLRSKQIESACFSGT 176
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 294-455 1.05e-08

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 55.01  E-value: 1.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 294 FGKSLT-IICKDGNLPAPVLDMLSIIDAKGPDTERIFRTLANKPYLT-LREKLDS-AEEMNLREESVYIVASVLKEFIRN 370
Cdd:cd04406     1 FGVELSrLTSEDRSVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKeLRQGLDTdANSVNLDDYNIHVIASVFKQWLRD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 371 IPGSLLCSNLYGKWLAVLDQEFHDQKISAIQSLLIQMPLPNVLLLRHLLSVLHKIKGRSSITHMTAYALSVRIAPSMLWN 450
Cdd:cd04406    81 LPNPLMTFELYEEFLRAMGLQERRETVRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEETNRMSANALAIVFAPCILRC 160


                  ....*
gi 1269208379 451 PSLSN 455
Cdd:cd04406   161 PDTTD 165
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 294-447 1.10e-08

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 55.50  E-value: 1.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 294 FGKSLTIIC-KDGN-LPAPVLDMLSIIDAKGPDTERIFRTLANKPYL-TLREKLDSAEE-MNLREESVYIVASVLKEFIR 369
Cdd:cd04375     5 FGVPLLVNLqRTGQpLPRSIQQAMRWLRNNALDQVGLFRKSGVKSRIqKLRSMIESSTDnVNYDGQQAYDVADMLKQYFR 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1269208379 370 NIPGSLLCSNLYGKWLAVLDQEFHDQKISAIQSLLIQMPLPNVLLLRHLLSVLHKIKGRSSITHMTAYALSVRIAPSM 447
Cdd:cd04375    85 DLPEPLLTNKLSETFIAIFQYVPKEQRLEAVQCAILLLPDENREVLQTLLYFLSDVAANSQENQMTATNLAVCLAPSL 162
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 27-177 2.03e-08

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 54.44  E-value: 2.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  27 EGIFRISGNMSACHALKERLDYGKK-VNLKKECVLAVASVLKEFLHNIQGSVLTSRLYDIWL------------DVLDQE 93
Cdd:cd04408    35 QGIYRISGSKARVEKLCQAFENGRDlVDLSGHSPHDITSVLKHFLKELPEPVLPFQLYDDFIalakelqrdsekAAESPS 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  94 NEEEKLAAVQSLLQRLPYPNVSLLRELFRMLHNIERNSAVNKMTAYSLSVCMAPCILCLPRSCNSGLAN--DISNEISLV 171
Cdd:cd04408   115 IVENIIRSLKELLGRLPVSNYNTLRHLMAHLYRVAERFEDNKMSPNNLGIVFGPTLLRPLVGGDVSMICllDTGYQAQLV 194


                  ....*.
gi 1269208379 172 KFLIEN 177
Cdd:cd04408   195 EFLISN 200
RhoGAP_PARG1 cd04409
RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 17-175 7.46e-08

RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239874  Cd Length: 211  Bit Score: 52.89  E-value: 7.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  17 SILNEKGAITEGIFRISGNMSACHALKERLDYGKK-VNLKKECVLAVASVLKEFLHNIQGSVLTSRLYDIWLDV------ 89
Cdd:cd04409    25 SEIESRALCLKGIYRVNGAKSRVEKLCQAFENGKDlVELSELSPHDISNVLKLYLRQLPEPLILFRLYNEFIGLakesqh 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  90 LDQENEEEKLAA----------------VQSLLQRLPYPNVSLLRELFRMLHNIERNSAVNKMTAYSLSVCMAPCiLCLP 153
Cdd:cd04409   105 VNETQEAKKNSDkkwpnmctelnrillkSKDLLRQLPAPNYNTLQFLIVHLHRVSEQAEENKMSASNLGIIFGPT-LIRP 183

                         170       180
                  ....*....|....*....|....*..
gi 1269208379 154 RSCN-----SGLAnDISNEISLVKFLI 175
Cdd:cd04409   184 RPTDatvslSSLV-DYPHQARLVELLI 209
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 294-455 2.27e-07

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 51.15  E-value: 2.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 294 FGKSLTIICKDGNlPAPVL--DMLSIIDAKGPDTERIFRT--LANKpYLTLREKLDS-AEEMNLREESVYIVASVLKEFI 368
Cdd:cd04407     1 FGVRVGSLTSNKT-SVPIVleKLLEHVEMHGLYTEGIYRKsgSANR-MKELHQLLQAdPENVKLENYPIHAITGLLKQWL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 369 RNIPGSLLCSNLYGKWLAVLDQEFHDQKISAIQSLLIQMPLPNVLLLRHLLSVLHKIKGRSSITHMTAYALSVRIAPSML 448
Cdd:cd04407    79 RELPEPLMTFAQYNDFLRAVELPEKQEQLQAIYRVLEQLPTANHNTLERLIFHLVKVALEEDVNRMSPNALAIVFAPCLL 158


                  ....*..
gi 1269208379 449 WNPSLSN 455
Cdd:cd04407   159 RCPDSSD 165
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 316-447 1.51e-06

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 48.55  E-value: 1.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 316 SIIDAKGPDTERIFRTLANKPYLT-LREKLDSA-EEMNLREE---SVYIVASVLKEFIRNIPGSLLCSNLYGKWLAVLDQ 390
Cdd:cd04395    27 NIVEARGLETVGIYRVPGNNAAISaLQEELNRGgFDIDLQDPrwrDVNVVSSLLKSFFRKLPEPLFTNELYPDFIEANRI 106

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1269208379 391 EFHDQKISAIQSLLIQMPLPNVLLLRHLLSVLHKIKGRSSITHMTAYALSVRIAPSM 447
Cdd:cd04395   107 EDPVERLKELRRLIHSLPDHHYETLKHLIRHLKTVADNSEVNKMEPRNLAIVFGPTL 163
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 293-446 2.40e-06

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 47.84  E-value: 2.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 293 LFGKSLTIICKDG----NLPAPVLDMLSIIDAKGPDTERIFRTLAN-KPYLTLREKLDSAEEMNLREES-VYIVASVLKE 366
Cdd:cd04393     2 VFGVPLQELQQAGqpenGVPAVVRHIVEYLEQHGLEQEGLFRVNGNaETVEWLRQRLDSGEEVDLSKEAdVCSAASLLRL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 367 FIRNIPGSLLCSNLYGKWLAVL-DQEFHDQKISAIQSLLIQMPLPNVLLLRHLLSVLHKIKGRSSITHMTAYALSVRIAP 445
Cdd:cd04393    82 FLQELPEGLIPASLQIRLMQLYqDYNGEDEFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHHENRMTAENLAAVFGP 161


                  .
gi 1269208379 446 S 446
Cdd:cd04393   162 D 162
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 294-458 8.15e-06

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 46.29  E-value: 8.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 294 FGKSL-TIICKDGNLPAPVLDMLSIIDAKGPDTERIFRTLANKPYL-TLREKLDSAEEMNLREE--SVYIVASVLKEFIR 369
Cdd:cd04373     1 FGVPLaNVVTSEKPIPIFLEKCVEFIEATGLETEGIYRVSGNKTHLdSLQKQFDQDHNLDLVSKdfTVNAVAGALKSFFS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 370 NIPGSLLCSNLYGKWLAVLDQEFHDQKISAIQSLLIQMPLPNVLLLRHLLSVLHKIKGRSSITHMTAYALSVRIAPSmLW 449
Cdd:cd04373    81 ELPDPLIPYSMHLELVEAAKINDREQRLHALKELLKKFPPENFDVFKYVITHLNKVSQNSKVNLMTSENLSICFWPT-LM 159


                  ....*....
gi 1269208379 450 NPSLSNSGF 458
Cdd:cd04373   160 RPDFTSMEA 168
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 294-408 9.07e-06

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 46.59  E-value: 9.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 294 FGKSLTIIC-KDG------------NLPAPVLDMLSIIDAKGPDTERIFRTLANKPYL-TLREKLDSA--EEMNLREESV 357
Cdd:cd04397     1 FGVPLEILVeKFGadstlgvgpgklRIPALIDDIISAMRQMDMSVEGVFRKNGNIRRLkELTEEIDKNptEVPDLSKENP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1269208379 358 YIVASVLKEFIRNIPGSLLCSNLYGKWLAVLDQEFHDQKISAIQSLLIQMP 408
Cdd:cd04397    81 VQLAALLKKFLRELPDPLLTFKLYRLWISSQKIEDEEERKRVLHLVYCLLP 131
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 294-447 1.61e-05

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 45.50  E-value: 1.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 294 FGKSLTI-----ICKDG-NLPAPVLDMLSIIDAKGPDTERIFRTLANKPYLT-LREKLDSAEEMNLREESVYIVASVLKE 366
Cdd:cd04381     1 FGASLSLaversRCHDGiDLPLVFRECIDYVEKHGMKCEGIYKVSGIKSKVDeLKAAYNRRESPNLEEYEPPTVASLLKQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 367 FIRNIPGSLLCSNLYGKWLAVLDQEFHDQKISAIQSLLIQMPLPNVLLLRHLLSVLHKIKGRSSITHMTAYALSVRIAPS 446
Cdd:cd04381    81 YLRELPEPLLTKELMPRFEEACGRPTEAEREQELQRLLKELPECNRLLLAWLIVHMDHVIAQELETKMNIQNISIVLSPT 160


                  .
gi 1269208379 447 M 447
Cdd:cd04381   161 V 161
RhoGAP_fRGD2 cd04399
RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 40-184 3.06e-05

RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD2-like proteins. Yeast Rgd2 is a GAP protein for Cdc42 and Rho5. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239864  Cd Length: 212  Bit Score: 45.02  E-value: 3.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  40 HALKERLDYGKKVN-----LKKECVLAVASVLKEFLHNIQGSVLTSRLYDIwLDVL-------DQENEEEKLAAVQSLLQ 107
Cdd:cd04399    54 HQLRNLLNKPKKPDkeviiLKKFEPSTVASVLKLYLLELPDSLIPHDIYDL-IRSLysayppsQEDSDTARIQGLQSTLS 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 108 RLPYPNV----SLLRELFRMLHNIERNSAVNKMTAY---SLSVCMAPCILCLPRSCNSGLANDISNEislvkfLIENSLK 180
Cdd:cd04399   133 QLPKSHIatldAIITHFYRLIEITKMGESEEEYADKlatSLSREILRPIIESLLTIGDKHGYKFFRD------LLTHKDQ 206


                  ....
gi 1269208379 181 IFGE 184
Cdd:cd04399   207 IFSE 210
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 62-176 3.60e-05

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 44.76  E-value: 3.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379  62 VASVLKEFLHNIQGSVLTSRLYDIWLDVL-----DQENEEEKLaaVQSLLQRLPYPNVSLLRELFRMLHNIERNSAVNKM 136
Cdd:cd04379    76 ITGVLKDYLRELPEPLITPQLYEMVLEALavalpNDVQTNTHL--TLSIIDCLPLSAKATLLLLLDHLSLVLSNSERNKM 153

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1269208379 137 TAYSLSVCMAPCIL-----CLP--RSCNSGLA----NDISNEISLVKFLIE 176
Cdd:cd04379   154 TPQNLAVCFGPVLMfcsqeFSRygISPTSKMAavstVDFKQHIEVLHYLLQ 204
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 294-468 1.57e-04

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 42.50  E-value: 1.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 294 FGKSLTIICKDGNLPAP-VLDM-LSIIDAKGPDTERIFRTLANKPYL-TLREKLDSAEEMNLREESVY----IVASVLKE 366
Cdd:cd04372     1 YGCDLTTLVKAHNTQRPmVVDMcIREIEARGLQSEGLYRVSGFAEEIeDVKMAFDRDGEKADISATVYpdinVITGALKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 367 FIRNIPGSLLCSNLYGKWLAVLDQEFHDQKISAIQSLLIQMPLPNVLLLRHLLSVLHKIKGRSSITHMTAYALSVRIAPS 446
Cdd:cd04372    81 YFRDLPIPVITYDTYPKFIDAAKISNPDERLEAVHEALMLLPPAHYETLRYLMEHLKRVTLHEKDNKMNAENLGIVFGPT 160

                         170       180
                  ....*....|....*....|..
gi 1269208379 447 MLWNPSLSNSGFGNDISQKKRL 468
Cdd:cd04372   161 LMRPPEDSALTTLNDMRYQILI 182
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 293-447 1.87e-03

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 39.64  E-value: 1.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 293 LFGKSLTIIC-----KDGNLPAPVL--DMLSIIDAKGPDTERIFRTLANKPYL-TLREKLDS---AEEMNLREESVYIVA 361
Cdd:cd04391     1 LFGVPLSTLLerdqkKVPGSKVPLIfqKLINKLEERGLETEGILRIPGSAQRVkFLCQELEAkfyEGTFLWDQVKQHDAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 362 SVLKEFIRNIPGSLLCSNLYGKWLAVLDQEFHDQKISAIQSLLIQMPLPNVLLLRHLLSVLHKIKGRSSITHMTAYALSV 441
Cdd:cd04391    81 SLLKLFIRELPQPLLTVEYLPAFYSVQGLPSKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEEKNKMNLWNVAM 160


                  ....*.
gi 1269208379 442 RIAPSM 447
Cdd:cd04391   161 IMAPNL 166
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 307-463 2.61e-03

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 39.03  E-value: 2.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 307 LPAPVLDMLSIIDAKGPDTERIFRTLANKPYLtlrEKLDSAEE-----MNLREESVYIVASVLKEFIRNIPGSLLCSNLY 381
Cdd:cd04408    16 VPFVVVRCTAEIENRALGVQGIYRISGSKARV---EKLCQAFEngrdlVDLSGHSPHDITSVLKHFLKELPEPVLPFQLY 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 382 GKWLAVLDQ------------EFHDQKISAIQSLLIQMPLPNVLLLRHLLSVLHKIKGRSSITHMTAYALSVRIAPSMLW 449
Cdd:cd04408    93 DDFIALAKElqrdsekaaespSIVENIIRSLKELLGRLPVSNYNTLRHLMAHLYRVAERFEDNKMSPNNLGIVFGPTLLR 172

                         170
                  ....*....|....
gi 1269208379 450 NPSlsnsgfGNDIS 463
Cdd:cd04408   173 PLV------GGDVS 180
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 316-448 3.85e-03

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 38.56  E-value: 3.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208379 316 SIIDAKGPDTERIFRTLANKPYLtlrEKLDSAEE-----MNLREESVYIVASVLKEFIRNIPGSLLCSNLYGKWLAV--- 387
Cdd:cd04378    25 SEIENRALGVQGIYRVSGSKARV---EKLCQAFEngkdlVELSELSPHDISSVLKLFLRQLPEPLILFRLYNDFIALake 101

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1269208379 388 ---LDQEFHDQKI-----SAIQS---LLIQMPLPNVLLLRHLLSVLHKIKGRSSITHMTAYALSVRIAPSML 448
Cdd:cd04378   102 iqrDTEEDKAPNTpievnRIIRKlkdLLRQLPASNYNTLQHLIAHLYRVAEQFEENKMSPNNLGIVFGPTLI 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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