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Conserved domains on  [gi|1268743669|ref|NP_001344081|]
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CREB-regulated transcription coactivator 2 isoform 2 [Mus musculus]

Protein Classification

TORC_M and TORC_C domain-containing protein( domain architecture ID 10331752)

TORC_M and TORC_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TORC_M super family cl15143
Transducer of regulated CREB activity middle domain; This family includes the region between ...
 1-138 1.93e-38

Transducer of regulated CREB activity middle domain; This family includes the region between the N and C terminus of TORC proteins. TORC (Transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerization domain of CREB (cAMP Response Element-Binding). Although the C- and N- terminal domains of these proteins have been well characterized, no functional role has been assigned to the central region, yet.


The actual alignment was detected with superfamily member pfam12885:

Pssm-ID: 463739  Cd Length: 154  Bit Score: 137.57  E-value: 1.93e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1268743669   1 MNPNPQDTYPGPTPPSVLPSRRGGGfldgEMDAKVPAIEENVVDDKHLL--KPWDAKKLSSSSSRPRSCEVPGINIFPSP 78
Cdd:pfam12885  13 MNPNPQDPFTGGSQELQPAPRGFGR----VLLLTVPGTEENLLEVDKPLpkQLWDAKKVQSLSSRPKSCEVPGINIFPSP 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1268743669  79 DQPANVPVLPPAMNTGGSLPDLTNLHFPPPLPTPLDPEETVYPSLSGGNSTTNLTHTMTH 138
Cdd:pfam12885  89 DQNATLSLFPAALNTGGSLPDLTNLHFPSPLPTPLDPEDTAFPSLSGGNSTGNLAAAMTH 148
TORC_C pfam12886
Transducer of regulated CREB activity, C terminus; This family includes the C terminal region ...
 435-512 1.37e-30

Transducer of regulated CREB activity, C terminus; This family includes the C terminal region of TORC proteins. TORC (Transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerization domain of CREB (cAMP Response Element-Binding). The C terminus region is negatively charged, resembling the transcription activation domains. When this domain, from all three human TORC proteins, was expressed as fusion proteins with the DNA-binding domain of GAL4 (GAL4-BD), and tested for induction of a minimal promoter linked to GAL4-binding sites (UAS-GAL4), UAS-GAL4 was potently induced by GAL4-BD fusions containing the C-terminal portion of all three human TORCs.


:

Pssm-ID: 463740  Cd Length: 75  Bit Score: 113.64  E-value: 1.37e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1268743669 435 PNIILTGDSSPGFSKEIAAALAGVPGFEVSASGLelgLGLEDELRMEPLGLEGLTMLSDPCALLPDPAVEDSFRSDRL 512
Cdd:pfam12886   1 PNIILTGDSSPGFSKDLSSALAGVPEVSFDADDL---FPLDDELGIEPLDLDGLQMLSDPDMVLPDPATEDTFRSDRL 75
 
Name Accession Description Interval E-value
TORC_M pfam12885
Transducer of regulated CREB activity middle domain; This family includes the region between ...
 1-138 1.93e-38

Transducer of regulated CREB activity middle domain; This family includes the region between the N and C terminus of TORC proteins. TORC (Transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerization domain of CREB (cAMP Response Element-Binding). Although the C- and N- terminal domains of these proteins have been well characterized, no functional role has been assigned to the central region, yet.


Pssm-ID: 463739  Cd Length: 154  Bit Score: 137.57  E-value: 1.93e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1268743669   1 MNPNPQDTYPGPTPPSVLPSRRGGGfldgEMDAKVPAIEENVVDDKHLL--KPWDAKKLSSSSSRPRSCEVPGINIFPSP 78
Cdd:pfam12885  13 MNPNPQDPFTGGSQELQPAPRGFGR----VLLLTVPGTEENLLEVDKPLpkQLWDAKKVQSLSSRPKSCEVPGINIFPSP 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1268743669  79 DQPANVPVLPPAMNTGGSLPDLTNLHFPPPLPTPLDPEETVYPSLSGGNSTTNLTHTMTH 138
Cdd:pfam12885  89 DQNATLSLFPAALNTGGSLPDLTNLHFPSPLPTPLDPEDTAFPSLSGGNSTGNLAAAMTH 148
TORC_C pfam12886
Transducer of regulated CREB activity, C terminus; This family includes the C terminal region ...
 435-512 1.37e-30

Transducer of regulated CREB activity, C terminus; This family includes the C terminal region of TORC proteins. TORC (Transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerization domain of CREB (cAMP Response Element-Binding). The C terminus region is negatively charged, resembling the transcription activation domains. When this domain, from all three human TORC proteins, was expressed as fusion proteins with the DNA-binding domain of GAL4 (GAL4-BD), and tested for induction of a minimal promoter linked to GAL4-binding sites (UAS-GAL4), UAS-GAL4 was potently induced by GAL4-BD fusions containing the C-terminal portion of all three human TORCs.


Pssm-ID: 463740  Cd Length: 75  Bit Score: 113.64  E-value: 1.37e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1268743669 435 PNIILTGDSSPGFSKEIAAALAGVPGFEVSASGLelgLGLEDELRMEPLGLEGLTMLSDPCALLPDPAVEDSFRSDRL 512
Cdd:pfam12886   1 PNIILTGDSSPGFSKDLSSALAGVPEVSFDADDL---FPLDDELGIEPLDLDGLQMLSDPDMVLPDPATEDTFRSDRL 75
 
Name Accession Description Interval E-value
TORC_M pfam12885
Transducer of regulated CREB activity middle domain; This family includes the region between ...
 1-138 1.93e-38

Transducer of regulated CREB activity middle domain; This family includes the region between the N and C terminus of TORC proteins. TORC (Transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerization domain of CREB (cAMP Response Element-Binding). Although the C- and N- terminal domains of these proteins have been well characterized, no functional role has been assigned to the central region, yet.


Pssm-ID: 463739  Cd Length: 154  Bit Score: 137.57  E-value: 1.93e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1268743669   1 MNPNPQDTYPGPTPPSVLPSRRGGGfldgEMDAKVPAIEENVVDDKHLL--KPWDAKKLSSSSSRPRSCEVPGINIFPSP 78
Cdd:pfam12885  13 MNPNPQDPFTGGSQELQPAPRGFGR----VLLLTVPGTEENLLEVDKPLpkQLWDAKKVQSLSSRPKSCEVPGINIFPSP 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1268743669  79 DQPANVPVLPPAMNTGGSLPDLTNLHFPPPLPTPLDPEETVYPSLSGGNSTTNLTHTMTH 138
Cdd:pfam12885  89 DQNATLSLFPAALNTGGSLPDLTNLHFPSPLPTPLDPEDTAFPSLSGGNSTGNLAAAMTH 148
TORC_C pfam12886
Transducer of regulated CREB activity, C terminus; This family includes the C terminal region ...
 435-512 1.37e-30

Transducer of regulated CREB activity, C terminus; This family includes the C terminal region of TORC proteins. TORC (Transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerization domain of CREB (cAMP Response Element-Binding). The C terminus region is negatively charged, resembling the transcription activation domains. When this domain, from all three human TORC proteins, was expressed as fusion proteins with the DNA-binding domain of GAL4 (GAL4-BD), and tested for induction of a minimal promoter linked to GAL4-binding sites (UAS-GAL4), UAS-GAL4 was potently induced by GAL4-BD fusions containing the C-terminal portion of all three human TORCs.


Pssm-ID: 463740  Cd Length: 75  Bit Score: 113.64  E-value: 1.37e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1268743669 435 PNIILTGDSSPGFSKEIAAALAGVPGFEVSASGLelgLGLEDELRMEPLGLEGLTMLSDPCALLPDPAVEDSFRSDRL 512
Cdd:pfam12886   1 PNIILTGDSSPGFSKDLSSALAGVPEVSFDADDL---FPLDDELGIEPLDLDGLQMLSDPDMVLPDPATEDTFRSDRL 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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