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Conserved domains on  [gi|1251770394|ref|NP_001343395|]
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GPI mannosyltransferase 2 isoform 1 [Mus musculus]

Protein Classification

glycosyltransferase family protein( domain architecture ID 10514647)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Mannosyl_trans2 pfam04188
Mannosyltransferase (PIG-V); This is a family of eukaryotic ER membrane proteins that are ...
 9-493 1.71e-166

Mannosyltransferase (PIG-V); This is a family of eukaryotic ER membrane proteins that are involved in the synthesis of glycosylphosphatidylinositol (GPI), a glycolipid that anchors many proteins to the eukaryotic cell surface. Proteins in this family are involved in transferring the second mannose in the biosynthetic pathway of GPI.


:

Pssm-ID: 282094  Cd Length: 439  Bit Score: 477.48  E-value: 1.71e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1251770394   9 KEVLRFAVNCRILTLVLQALFN-LIIPDHHADAFCPPRLAPSGSADQLVEGLLGGLSRWDAEHFLFIAEHGYLYEHNFAF 87
Cdd:pfam04188   2 KELTLYAVLFRSLQLLLVFLTPiRQFPTSTSLALNPPCSASPSEVNSYWNKYLWNLLSWDSVFFLKISENGYQYEHEYAF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1251770394  88 FPGFPLALLMGT-ELLRPLQGLLSQRSCLLVSVALLNLLFSVLAAVALHDLGCLVLHCPRQALCAALLFCISPANVFLAA 166
Cdd:pfam04188  82 SPLWPFFVRLFIkSNNDPLYHLLRLRVAIENSLFYLSILLFFLAAKILSQNIRQSLFARTISFKASLLFCLTPAAGFLTS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1251770394 167 GYSEALFAFLTFSAMGQLERGRGWASGLLFALAAGVRSNGLVSLGFLLHSQCRGFCSSLAVLSPWKPLVKLMASVCLSVL 246
Cdd:pfam04188 162 IYSEPLSALFAFVGIWSLECGIDISWVLWFAYSFIMRSNGLASLGRSNCVLLGIYFIDLIELTKNRKFVKAICFPFLSGS 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1251770394 247 IVSLPFALFQYRAYIQFCSPGSAPsipepllqlaadkgyrlageNAPPWCSWDLPLIYNYIQDVYWNVGLLRYYELKQVP 326
Cdd:pfam04188 242 LMFLPFLYFQYYLYKTFCPQRSAG--------------------NEPPWCKSQLPLLYSYIQSHYWGVGFLKYWTPKQIP 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1251770394 327 NFLLATPVTVLVVWATWTYVTTHPWLCLTLGLQRTKDRENPEKPHRGFLSPKVFVYLVHAAALLVFGGLCMHVQVLTRFL 406
Cdd:pfam04188 302 NFLLAVPNIILLIYSSIYYSKTHPWLCLTLGLQYPSYNKKAEKPDLGFLSPQVFVLVVHTRALVVIVCFFMHVQVLTRFL 381

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1251770394 407 aSSTPIMYWFPAHLLQDqepllrcvdtepgkLPQEKSPPGQKAPrncLMKLFYDWKRCSpvtrcvlvyflTYWLLGLILH 486
Cdd:pfam04188 382 -SFLPLHYWFLADLLVS--------------DKKKMWNPLGDDK---IVKFYIYWLACS-----------FYILLGTLLF 432


                  ....*..
gi 1251770394 487 CNFLPWT 493
Cdd:pfam04188 433 ANFLPPT 439
 
Name Accession Description Interval E-value
Mannosyl_trans2 pfam04188
Mannosyltransferase (PIG-V); This is a family of eukaryotic ER membrane proteins that are ...
 9-493 1.71e-166

Mannosyltransferase (PIG-V); This is a family of eukaryotic ER membrane proteins that are involved in the synthesis of glycosylphosphatidylinositol (GPI), a glycolipid that anchors many proteins to the eukaryotic cell surface. Proteins in this family are involved in transferring the second mannose in the biosynthetic pathway of GPI.


Pssm-ID: 282094  Cd Length: 439  Bit Score: 477.48  E-value: 1.71e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1251770394   9 KEVLRFAVNCRILTLVLQALFN-LIIPDHHADAFCPPRLAPSGSADQLVEGLLGGLSRWDAEHFLFIAEHGYLYEHNFAF 87
Cdd:pfam04188   2 KELTLYAVLFRSLQLLLVFLTPiRQFPTSTSLALNPPCSASPSEVNSYWNKYLWNLLSWDSVFFLKISENGYQYEHEYAF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1251770394  88 FPGFPLALLMGT-ELLRPLQGLLSQRSCLLVSVALLNLLFSVLAAVALHDLGCLVLHCPRQALCAALLFCISPANVFLAA 166
Cdd:pfam04188  82 SPLWPFFVRLFIkSNNDPLYHLLRLRVAIENSLFYLSILLFFLAAKILSQNIRQSLFARTISFKASLLFCLTPAAGFLTS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1251770394 167 GYSEALFAFLTFSAMGQLERGRGWASGLLFALAAGVRSNGLVSLGFLLHSQCRGFCSSLAVLSPWKPLVKLMASVCLSVL 246
Cdd:pfam04188 162 IYSEPLSALFAFVGIWSLECGIDISWVLWFAYSFIMRSNGLASLGRSNCVLLGIYFIDLIELTKNRKFVKAICFPFLSGS 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1251770394 247 IVSLPFALFQYRAYIQFCSPGSAPsipepllqlaadkgyrlageNAPPWCSWDLPLIYNYIQDVYWNVGLLRYYELKQVP 326
Cdd:pfam04188 242 LMFLPFLYFQYYLYKTFCPQRSAG--------------------NEPPWCKSQLPLLYSYIQSHYWGVGFLKYWTPKQIP 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1251770394 327 NFLLATPVTVLVVWATWTYVTTHPWLCLTLGLQRTKDRENPEKPHRGFLSPKVFVYLVHAAALLVFGGLCMHVQVLTRFL 406
Cdd:pfam04188 302 NFLLAVPNIILLIYSSIYYSKTHPWLCLTLGLQYPSYNKKAEKPDLGFLSPQVFVLVVHTRALVVIVCFFMHVQVLTRFL 381

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1251770394 407 aSSTPIMYWFPAHLLQDqepllrcvdtepgkLPQEKSPPGQKAPrncLMKLFYDWKRCSpvtrcvlvyflTYWLLGLILH 486
Cdd:pfam04188 382 -SFLPLHYWFLADLLVS--------------DKKKMWNPLGDDK---IVKFYIYWLACS-----------FYILLGTLLF 432


                  ....*..
gi 1251770394 487 CNFLPWT 493
Cdd:pfam04188 433 ANFLPPT 439
COG5542 COG5542
Mannosyltransferase related to Gpi18 [Carbohydrate transport and metabolism];
66-254 5.69e-10

Mannosyltransferase related to Gpi18 [Carbohydrate transport and metabolism];


Pssm-ID: 444286 [Multi-domain]  Cd Length: 208  Bit Score: 59.19  E-value: 5.69e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1251770394  66 WDAEHFLFIAEHGYLY----EHNfAFFPGFPLALLMGTELLRPlqgllsqrscLLVSVALLNLLFSVLAAVALHDLgCLV 141
Cdd:COG5542     4 FLSPWYRAIATSGYFAalgkQFG-DYFPLYPYLLRLVMYLGLP----------FLLAGKLVSILADLVAAYLLYRW-VKK 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1251770394 142 LHCPRQALCAALLFCISPANVFLAAGY--SEALFAFLTFSAMGQLERGRGWASGLLFALAAGVRSNGLVSLGFLLHSQCR 219
Cdd:COG5542    72 YYGGNAALLAAAVLAFLPTVLLNSAIWgqTDSLYTLFSLAALYALLRGRYGWAALFFALATAFKPQAVFLLPALLILLLK 151

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1251770394 220 gfcsslavlspWKPLVKLMASVCLSVLIVSLPFAL 254
Cdd:COG5542   152 -----------ERIRLAYLLLAPVVYALALLPALL 175
 
Name Accession Description Interval E-value
Mannosyl_trans2 pfam04188
Mannosyltransferase (PIG-V); This is a family of eukaryotic ER membrane proteins that are ...
 9-493 1.71e-166

Mannosyltransferase (PIG-V); This is a family of eukaryotic ER membrane proteins that are involved in the synthesis of glycosylphosphatidylinositol (GPI), a glycolipid that anchors many proteins to the eukaryotic cell surface. Proteins in this family are involved in transferring the second mannose in the biosynthetic pathway of GPI.


Pssm-ID: 282094  Cd Length: 439  Bit Score: 477.48  E-value: 1.71e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1251770394   9 KEVLRFAVNCRILTLVLQALFN-LIIPDHHADAFCPPRLAPSGSADQLVEGLLGGLSRWDAEHFLFIAEHGYLYEHNFAF 87
Cdd:pfam04188   2 KELTLYAVLFRSLQLLLVFLTPiRQFPTSTSLALNPPCSASPSEVNSYWNKYLWNLLSWDSVFFLKISENGYQYEHEYAF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1251770394  88 FPGFPLALLMGT-ELLRPLQGLLSQRSCLLVSVALLNLLFSVLAAVALHDLGCLVLHCPRQALCAALLFCISPANVFLAA 166
Cdd:pfam04188  82 SPLWPFFVRLFIkSNNDPLYHLLRLRVAIENSLFYLSILLFFLAAKILSQNIRQSLFARTISFKASLLFCLTPAAGFLTS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1251770394 167 GYSEALFAFLTFSAMGQLERGRGWASGLLFALAAGVRSNGLVSLGFLLHSQCRGFCSSLAVLSPWKPLVKLMASVCLSVL 246
Cdd:pfam04188 162 IYSEPLSALFAFVGIWSLECGIDISWVLWFAYSFIMRSNGLASLGRSNCVLLGIYFIDLIELTKNRKFVKAICFPFLSGS 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1251770394 247 IVSLPFALFQYRAYIQFCSPGSAPsipepllqlaadkgyrlageNAPPWCSWDLPLIYNYIQDVYWNVGLLRYYELKQVP 326
Cdd:pfam04188 242 LMFLPFLYFQYYLYKTFCPQRSAG--------------------NEPPWCKSQLPLLYSYIQSHYWGVGFLKYWTPKQIP 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1251770394 327 NFLLATPVTVLVVWATWTYVTTHPWLCLTLGLQRTKDRENPEKPHRGFLSPKVFVYLVHAAALLVFGGLCMHVQVLTRFL 406
Cdd:pfam04188 302 NFLLAVPNIILLIYSSIYYSKTHPWLCLTLGLQYPSYNKKAEKPDLGFLSPQVFVLVVHTRALVVIVCFFMHVQVLTRFL 381

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1251770394 407 aSSTPIMYWFPAHLLQDqepllrcvdtepgkLPQEKSPPGQKAPrncLMKLFYDWKRCSpvtrcvlvyflTYWLLGLILH 486
Cdd:pfam04188 382 -SFLPLHYWFLADLLVS--------------DKKKMWNPLGDDK---IVKFYIYWLACS-----------FYILLGTLLF 432


                  ....*..
gi 1251770394 487 CNFLPWT 493
Cdd:pfam04188 433 ANFLPPT 439
COG5542 COG5542
Mannosyltransferase related to Gpi18 [Carbohydrate transport and metabolism];
66-254 5.69e-10

Mannosyltransferase related to Gpi18 [Carbohydrate transport and metabolism];


Pssm-ID: 444286 [Multi-domain]  Cd Length: 208  Bit Score: 59.19  E-value: 5.69e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1251770394  66 WDAEHFLFIAEHGYLY----EHNfAFFPGFPLALLMGTELLRPlqgllsqrscLLVSVALLNLLFSVLAAVALHDLgCLV 141
Cdd:COG5542     4 FLSPWYRAIATSGYFAalgkQFG-DYFPLYPYLLRLVMYLGLP----------FLLAGKLVSILADLVAAYLLYRW-VKK 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1251770394 142 LHCPRQALCAALLFCISPANVFLAAGY--SEALFAFLTFSAMGQLERGRGWASGLLFALAAGVRSNGLVSLGFLLHSQCR 219
Cdd:COG5542    72 YYGGNAALLAAAVLAFLPTVLLNSAIWgqTDSLYTLFSLAALYALLRGRYGWAALFFALATAFKPQAVFLLPALLILLLK 151

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1251770394 220 gfcsslavlspWKPLVKLMASVCLSVLIVSLPFAL 254
Cdd:COG5542   152 -----------ERIRLAYLLLAPVVYALALLPALL 175
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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