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Conserved domains on  [gi|1249618559|ref|NP_001343357|]
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pancreatic progenitor cell differentiation and proliferation factor isoform b [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPDFL super family cl20932
Differentiation and proliferation regulator; Pancreatic progenitor cell differentiation and ...
 1-85 2.87e-42

Differentiation and proliferation regulator; Pancreatic progenitor cell differentiation and proliferation factor-like protein (PPDFL) is alternatively named Exocrine differentiation and proliferation factor-like protein. PPDFL regulates exocrine cell fate. This protein is highly expressed in exocrine progenitor cells which eventually differentiate to form exocrine pancreatic cells.


The actual alignment was detected with superfamily member pfam15060:

Pssm-ID: 464477  Cd Length: 110  Bit Score: 133.45  E-value: 2.87e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618559   1 MAAIPSSGSLVATHDYYRR--------------------------LPKADPGHWWASFFFGKSTLPFMTTVLESPERSaE 54
Cdd:pfam15060   1 MAAIPSSGSLVATHDYYRRrlgstssnsscgsaeypgeviphhpgLPKADPGHWWASFFFGKSNLPFMATVLESPEHS-G 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1249618559  55 SPQVSRSPMTCGLTPETMKQQPVIHSGQTNP 85
Cdd:pfam15060  80 SPQASSGMITCDLAQEAMRKQPGSQPSKTSA 110
 
Name Accession Description Interval E-value
PPDFL pfam15060
Differentiation and proliferation regulator; Pancreatic progenitor cell differentiation and ...
 1-85 2.87e-42

Differentiation and proliferation regulator; Pancreatic progenitor cell differentiation and proliferation factor-like protein (PPDFL) is alternatively named Exocrine differentiation and proliferation factor-like protein. PPDFL regulates exocrine cell fate. This protein is highly expressed in exocrine progenitor cells which eventually differentiate to form exocrine pancreatic cells.


Pssm-ID: 464477  Cd Length: 110  Bit Score: 133.45  E-value: 2.87e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618559   1 MAAIPSSGSLVATHDYYRR--------------------------LPKADPGHWWASFFFGKSTLPFMTTVLESPERSaE 54
Cdd:pfam15060   1 MAAIPSSGSLVATHDYYRRrlgstssnsscgsaeypgeviphhpgLPKADPGHWWASFFFGKSNLPFMATVLESPEHS-G 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1249618559  55 SPQVSRSPMTCGLTPETMKQQPVIHSGQTNP 85
Cdd:pfam15060  80 SPQASSGMITCDLAQEAMRKQPGSQPSKTSA 110
 
Name Accession Description Interval E-value
PPDFL pfam15060
Differentiation and proliferation regulator; Pancreatic progenitor cell differentiation and ...
 1-85 2.87e-42

Differentiation and proliferation regulator; Pancreatic progenitor cell differentiation and proliferation factor-like protein (PPDFL) is alternatively named Exocrine differentiation and proliferation factor-like protein. PPDFL regulates exocrine cell fate. This protein is highly expressed in exocrine progenitor cells which eventually differentiate to form exocrine pancreatic cells.


Pssm-ID: 464477  Cd Length: 110  Bit Score: 133.45  E-value: 2.87e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1249618559   1 MAAIPSSGSLVATHDYYRR--------------------------LPKADPGHWWASFFFGKSTLPFMTTVLESPERSaE 54
Cdd:pfam15060   1 MAAIPSSGSLVATHDYYRRrlgstssnsscgsaeypgeviphhpgLPKADPGHWWASFFFGKSNLPFMATVLESPEHS-G 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1249618559  55 SPQVSRSPMTCGLTPETMKQQPVIHSGQTNP 85
Cdd:pfam15060  80 SPQASSGMITCDLAQEAMRKQPGSQPSKTSA 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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