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Conserved domains on  [gi|1246742950|ref|NP_001342781|]
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Swr1 complex histone chaperone module subunit, SNF2 family ATP-dependent chromatin remodeller Swr1 [Schizosaccharomyces pombe]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DEXQc_SRCAP cd18003
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ...
 447-679 1.52e-155

DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


:

Pssm-ID: 350761 [Multi-domain]  Cd Length: 223  Bit Score: 465.29  E-value: 1.52e-155
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  447 LREYQQYGLEWLTALHDSNTNGILADEMGLGKTIQTIALLAHLACEKENWGPHLIIVPTSVMLNWEMEFKKFLPGFKILT 526
Cdd:cd18003      1 LREYQHIGLDWLATLYEKNLNGILADEMGLGKTIQTIALLAHLACEKGNWGPHLIVVPTSVMLNWEMEFKRWCPGFKILT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  527 YYGNPQERKEKRSGWYKPDTWHVCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKNFRSQRWQSLLNFNAEHRLLLTGTP 606
Cdd:cd18003     81 YYGSAKERKLKRQGWMKPNSFHVCITSYQLVVQDHQVFKRKKWKYLILDEAHNIKNFKSQRWQTLLNFNTQRRLLLTGTP 160

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1246742950  607 LQNNLVELWSLLYFLMPagvtqnnSAFANLKDFQDWFSKPMDRLIEEGQDmnpEAMNTVAKLHRVLRPYLLRR 679
Cdd:cd18003    161 LQNSLMELWSLMHFLMP-------HIFQSHQEFKEWFSNPLTAMSEGSQE---ENEELVRRLHKVLRPFLLRR 223
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 432-1134 5.96e-111

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


:

Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 364.16  E-value: 5.96e-111
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  432 LHANKIQVPFLFRGTLREYQQYGLEWLTALHDSNTNGILADEMGLGKTIQTIALLAHLAcEKENWGPHLIIVPTSVMLNW 511
Cdd:COG0553    227 LREALESLPAGLKATLRPYQLEGAAWLLFLRRLGLGGLLADDMGLGKTIQALALLLELK-ERGLARPVLIVAPTSLVGNW 305

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  512 EMEFKKFLPGFKILTYYGnPQERKEKRSGWYKPDtwhVCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKNFRSQRWQSL 591
Cdd:COG0553    306 QRELAKFAPGLRVLVLDG-TRERAKGANPFEDAD---LVITSYGLLRRDIELLAAVDWDLVILDEAQHIKNPATKRAKAV 381

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  592 LNFNAEHRLLLTGTPLQNNLVELWSLLYFLMPaGVtqnnsaFANLKDFQDWFSKPmdrlIEEGqdmNPEAMntvAKLHRV 671
Cdd:COG0553    382 RALKARHRLALTGTPVENRLEELWSLLDFLNP-GL------LGSLKAFRERFARP----IEKG---DEEAL---ERLRRL 444

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  672 LRPYLLRRLKTEVEKQMPAKYEHVVYCQLSKRQRFLYDDFINRARtREILASGNF---MSIINCLMQLRKVCNHPnlhee 748
Cdd:COG0553    445 LRPFLLRRTKEDVLKDLPEKTEETLYVELTPEQRALYEAVLEYLR-RELEGAEGIrrrGLILAALTRLRQICSHP----- 518

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  749 rpivtsfalrrsAIADLEIKDLLVRKrllheepmTKLDlstlrlirtdseafdtfvsdelnslcatnaynristflrmqi 828
Cdd:COG0553    519 ------------ALLLEEGAELSGRS--------AKLE------------------------------------------ 536

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  829 deeckpcqfkksnfkehfqnkiyqeqldklnfqkylneskcshspiygsnliRLAEKLpkhstsidytlyakddplylln 908
Cdd:COG0553    537 ----------------------------------------------------ALLELL---------------------- 542

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  909 ttkalrscilsTEERASNMKeiiqrfacitpkaVVVdlpelFCktiprdllyevsrkinplhqastrlaiafpdkrllQY 988
Cdd:COG0553    543 -----------EELLAEGEK-------------VLV-----FS-----------------------------------QF 558

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  989 dcgkLQVLDRLLKDLVSNGHRVLIFtqmtkvldileqflnihghrylrlDGATKIEQRQILTERFNNDDKIPVFILSTRS 1068
Cdd:COG0553    559 ----TDTLDLLEERLEERGIEYAYL------------------------HGGTSAEERDELVDRFQEGPEAPVFLISLKA 610

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1246742950 1069 GGLGINLTGADTVIFYDSDWNPQLDAQAQDRSHRIGQTRDVHIYRLISEYTVESNMLRRANQKRML 1134
Cdd:COG0553    611 GGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRAL 676
HSA super family cl47975
HSA domain; This domain is predicted to bind DNA and is often found associated with helicases. ...
 116-178 5.67e-04

HSA domain; This domain is predicted to bind DNA and is often found associated with helicases. This region does not form a compact domain in the known structures.


The actual alignment was detected with superfamily member pfam07529:

Pssm-ID: 462194 [Multi-domain]  Cd Length: 67  Bit Score: 39.48  E-value: 5.67e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1246742950  116 SYRDNLLSHVNGYARSMHNDRKVRASRSRRISGMILAHFKrlsgadeKKAKEEDKRIRLLAKR 178
Cdd:pfam07529   10 THHDYLLEEILWHSKDFKQERRWKRARAKKLARAVAQYHK-------NIEKEEQKRIEREEKQ 65
 
Name Accession Description Interval E-value
DEXQc_SRCAP cd18003
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ...
 447-679 1.52e-155

DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350761 [Multi-domain]  Cd Length: 223  Bit Score: 465.29  E-value: 1.52e-155
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  447 LREYQQYGLEWLTALHDSNTNGILADEMGLGKTIQTIALLAHLACEKENWGPHLIIVPTSVMLNWEMEFKKFLPGFKILT 526
Cdd:cd18003      1 LREYQHIGLDWLATLYEKNLNGILADEMGLGKTIQTIALLAHLACEKGNWGPHLIVVPTSVMLNWEMEFKRWCPGFKILT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  527 YYGNPQERKEKRSGWYKPDTWHVCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKNFRSQRWQSLLNFNAEHRLLLTGTP 606
Cdd:cd18003     81 YYGSAKERKLKRQGWMKPNSFHVCITSYQLVVQDHQVFKRKKWKYLILDEAHNIKNFKSQRWQTLLNFNTQRRLLLTGTP 160

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1246742950  607 LQNNLVELWSLLYFLMPagvtqnnSAFANLKDFQDWFSKPMDRLIEEGQDmnpEAMNTVAKLHRVLRPYLLRR 679
Cdd:cd18003    161 LQNSLMELWSLMHFLMP-------HIFQSHQEFKEWFSNPLTAMSEGSQE---ENEELVRRLHKVLRPFLLRR 223
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 432-1134 5.96e-111

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 364.16  E-value: 5.96e-111
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  432 LHANKIQVPFLFRGTLREYQQYGLEWLTALHDSNTNGILADEMGLGKTIQTIALLAHLAcEKENWGPHLIIVPTSVMLNW 511
Cdd:COG0553    227 LREALESLPAGLKATLRPYQLEGAAWLLFLRRLGLGGLLADDMGLGKTIQALALLLELK-ERGLARPVLIVAPTSLVGNW 305

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  512 EMEFKKFLPGFKILTYYGnPQERKEKRSGWYKPDtwhVCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKNFRSQRWQSL 591
Cdd:COG0553    306 QRELAKFAPGLRVLVLDG-TRERAKGANPFEDAD---LVITSYGLLRRDIELLAAVDWDLVILDEAQHIKNPATKRAKAV 381

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  592 LNFNAEHRLLLTGTPLQNNLVELWSLLYFLMPaGVtqnnsaFANLKDFQDWFSKPmdrlIEEGqdmNPEAMntvAKLHRV 671
Cdd:COG0553    382 RALKARHRLALTGTPVENRLEELWSLLDFLNP-GL------LGSLKAFRERFARP----IEKG---DEEAL---ERLRRL 444

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  672 LRPYLLRRLKTEVEKQMPAKYEHVVYCQLSKRQRFLYDDFINRARtREILASGNF---MSIINCLMQLRKVCNHPnlhee 748
Cdd:COG0553    445 LRPFLLRRTKEDVLKDLPEKTEETLYVELTPEQRALYEAVLEYLR-RELEGAEGIrrrGLILAALTRLRQICSHP----- 518

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  749 rpivtsfalrrsAIADLEIKDLLVRKrllheepmTKLDlstlrlirtdseafdtfvsdelnslcatnaynristflrmqi 828
Cdd:COG0553    519 ------------ALLLEEGAELSGRS--------AKLE------------------------------------------ 536

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  829 deeckpcqfkksnfkehfqnkiyqeqldklnfqkylneskcshspiygsnliRLAEKLpkhstsidytlyakddplylln 908
Cdd:COG0553    537 ----------------------------------------------------ALLELL---------------------- 542

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  909 ttkalrscilsTEERASNMKeiiqrfacitpkaVVVdlpelFCktiprdllyevsrkinplhqastrlaiafpdkrllQY 988
Cdd:COG0553    543 -----------EELLAEGEK-------------VLV-----FS-----------------------------------QF 558

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  989 dcgkLQVLDRLLKDLVSNGHRVLIFtqmtkvldileqflnihghrylrlDGATKIEQRQILTERFNNDDKIPVFILSTRS 1068
Cdd:COG0553    559 ----TDTLDLLEERLEERGIEYAYL------------------------HGGTSAEERDELVDRFQEGPEAPVFLISLKA 610

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1246742950 1069 GGLGINLTGADTVIFYDSDWNPQLDAQAQDRSHRIGQTRDVHIYRLISEYTVESNMLRRANQKRML 1134
Cdd:COG0553    611 GGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRAL 676
SNF2-rel_dom pfam00176
SNF2-related domain; This domain is found in proteins involved in a variety of processes ...
 450-745 4.36e-87

SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.


Pssm-ID: 425504 [Multi-domain]  Cd Length: 289  Bit Score: 284.58  E-value: 4.36e-87
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  450 YQQYGLEWLTALH-DSNTNGILADEMGLGKTIQTIALLAHLACEKENWG-PHLIIVPTSVMLNWEMEFKKFL--PGFKIL 525
Cdd:pfam00176    1 YQIEGVNWMLSLEnNLGRGGILADEMGLGKTLQTISLLLYLKHVDKNWGgPTLIVVPLSLLHNWMNEFERWVspPALRVV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  526 TYYGNPQERKEKRSGWYKPDTWHVCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKNFRSQRWQSLLNFNAEHRLLLTGT 605
Cdd:pfam00176   81 VLHGNKRPQERWKNDPNFLADFDVVITTYETLRKHKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWILTGT 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  606 PLQNNLVELWSLLYFLMPagvtqnnSAFANLKDFQDWFSKPMdrlieegqdMNPEAMNTVAKLHRVLRPYLLRRLKTEVE 685
Cdd:pfam00176  161 PLQNNLEELWALLNFLRP-------GPFGSLSTFRNWFDRPI---------ERGGGKKGVSRLHKLLKPFLLRRTKKDVE 224

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1246742950  686 KQMPAKYEHVVYCQLSKRQRFLYDDFINRARTREILAS----GNFMSIINCLMQLRKVCNHPNL 745
Cdd:pfam00176  225 KSLPPKVEYILFCRLSKLQRKLYQTFLLKKDLNAIKTGeggrEIKASLLNILMRLRKICNHPGL 288
PLN03142 PLN03142
Probable chromatin-remodeling complex ATPase chain; Provisional
 424-745 5.12e-75

Probable chromatin-remodeling complex ATPase chain; Provisional


Pssm-ID: 215601 [Multi-domain]  Cd Length: 1033  Bit Score: 270.90  E-value: 5.12e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  424 DEPNGSPVLHANKIQV-PFLFRGTLREYQQYGLEWLTALHDSNTNGILADEMGLGKTIQTIALLAHLACEKENWGPHLII 502
Cdd:PLN03142   146 EEEDGLGGSGGTRLLVqPSCIKGKMRDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLGYLHEYRGITGPHMVV 225

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  503 VPTSVMLNWEMEFKKFLPGFKILTYYGNPQERKEKRSGWYKPDTWHVCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKN 582
Cdd:PLN03142   226 APKSTLGNWMNEIRRFCPVLRAVKFHGNPEERAHQREELLVAGKFDVCVTSFEMAIKEKTALKRFSWRYIIIDEAHRIKN 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  583 FRSQRWQSLLNFNAEHRLLLTGTPLQNNLVELWSLLYFLMPagvtqnnSAFANLKDFQDWFSKpmdrlieEGQDMNPEam 662
Cdd:PLN03142   306 ENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLP-------EIFSSAETFDEWFQI-------SGENDQQE-- 369

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  663 nTVAKLHRVLRPYLLRRLKTEVEKQMPAKYEHVVYCQLSKRQRFLYD-------DFINRARTREILasgnfmsiINCLMQ 735
Cdd:PLN03142   370 -VVQQLHKVLRPFLLRRLKSDVEKGLPPKKETILKVGMSQMQKQYYKallqkdlDVVNAGGERKRL--------LNIAMQ 440

                          330
                   ....*....|
gi 1246742950  736 LRKVCNHPNL 745
Cdd:PLN03142   441 LRKCCNHPYL 450
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
 980-1115 4.46e-63

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 210.41  E-value: 4.46e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  980 FPDKRLLQYDcGKLQVLDRLLKDLVSNGHRVLIFTQMTKVLDILEQFLNIHGHRYLRLDGATKIEQRQILTERFNNDDKI 1059
Cdd:cd18793      1 LPPKIEEVVS-GKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDI 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1246742950 1060 PVFILSTRSGGLGINLTGADTVIFYDSDWNPQLDAQAQDRSHRIGQTRDVHIYRLI 1115
Cdd:cd18793     80 RVFLLSTKAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
PLN03142 PLN03142
Probable chromatin-remodeling complex ATPase chain; Provisional
 991-1145 1.09e-47

Probable chromatin-remodeling complex ATPase chain; Provisional


Pssm-ID: 215601 [Multi-domain]  Cd Length: 1033  Bit Score: 186.16  E-value: 1.09e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  991 GKLQVLDRLLKDLVSNGHRVLIFTQMTKVLDILEQFLNIHGHRYLRLDGATKIEQRQILTERFN--NDDKIpVFILSTRS 1068
Cdd:PLN03142   471 GKMVLLDKLLPKLKERDSRVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNkpGSEKF-VFLLSTRA 549

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1246742950 1069 GGLGINLTGADTVIFYDSDWNPQLDAQAQDRSHRIGQTRDVHIYRLISEYTVESNMLRRANQKRMLDKIVIQGGEFT 1145
Cdd:PLN03142   550 GGLGINLATADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKLALDALVIQQGRLA 626
DEXDc smart00487
DEAD-like helicases superfamily;
439-623 3.47e-30

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 118.75  E-value: 3.47e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950   439 VPFLFRGTLREYQQYGLEWLtalHDSNTNGILADEMGLGKTIQ-TIALLAHLAceKENWGPHLIIVPTSV-MLNWEMEFK 516
Cdd:smart00487    1 IEKFGFEPLRPYQKEAIEAL---LSGLRDVILAAPTGSGKTLAaLLPALEALK--RGKGGRVLVLVPTRElAEQWAEELK 75

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950   517 KFLP--GFKILTYYGNPQERKEKRSgWYKPDTwHVCITSYQLVLQD--HQPFRRKKWQYMILDEAHNIKNF-RSQRWQSL 591
Cdd:smart00487   76 KLGPslGLKVVGLYGGDSKREQLRK-LESGKT-DILVTTPGRLLDLleNDKLSLSNVDLVILDEAHRLLDGgFGDQLEKL 153

                           170       180       190
                    ....*....|....*....|....*....|....*..
gi 1246742950   592 LNF--NAEHRLLLTGTP---LQNNLVELWSLLYFLMP 623
Cdd:smart00487  154 LKLlpKNVQLLLLSATPpeeIENLLELFLNDPVFIDV 190
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 991-1104 4.49e-28

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 109.61  E-value: 4.49e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  991 GKLQVLDRLLKDlvSNGHRVLIFTQMTKVLDIlEQFLNIHGHRYLRLDGATKIEQRQILTERFNNDDKIpvFILSTRSGG 1070
Cdd:pfam00271    1 EKLEALLELLKK--ERGGKVLIFSQTKKTLEA-ELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKID--VLVATDVAE 75

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1246742950 1071 LGINLTGADTVIFYDSDWNPQLDAQAQDRSHRIG 1104
Cdd:pfam00271   76 RGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
HELICc smart00490
helicase superfamily c-terminal domain;
1021-1104 5.18e-23

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 94.20  E-value: 5.18e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  1021 DILEQFLNIHGHRYLRLDGATKIEQRQILTERFNNDDKipVFILSTRSGGLGINLTGADTVIFYDSDWNPQLDAQAQDRS 1100
Cdd:smart00490    1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKI--KVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRA 78


                    ....
gi 1246742950  1101 HRIG 1104
Cdd:smart00490   79 GRAG 82
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
443-606 2.22e-14

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 77.76  E-value: 2.22e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  443 FRGTLREYQQYGLE-WLTALHDSNTNGILADEMGLGKTIqtiaLLAHLACEKENWGPHLIIVPTSVMLN-WEMEFKKFLP 520
Cdd:COG1061     77 TSFELRPYQQEALEaLLAALERGGGRGLVVAPTGTGKTV----LALALAAELLRGKRVLVLVPRRELLEqWAEELRRFLG 152

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  521 GFKIltyygnpqerkekrSGWYKPDTWHVCITSYQ-LVLQDHQPFRRKKWQYMILDEAHNIknfRSQRWQSLLN-FNAEH 598
Cdd:COG1061    153 DPLA--------------GGGKKDSDAPITVATYQsLARRAHLDELGDRFGLVIIDEAHHA---GAPSYRRILEaFPAAY 215


                   ....*...
gi 1246742950  599 RLLLTGTP 606
Cdd:COG1061    216 RLGLTATP 223
HSA pfam07529
HSA domain; This domain is predicted to bind DNA and is often found associated with helicases. ...
 116-178 5.67e-04

HSA domain; This domain is predicted to bind DNA and is often found associated with helicases. This region does not form a compact domain in the known structures.


Pssm-ID: 462194 [Multi-domain]  Cd Length: 67  Bit Score: 39.48  E-value: 5.67e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1246742950  116 SYRDNLLSHVNGYARSMHNDRKVRASRSRRISGMILAHFKrlsgadeKKAKEEDKRIRLLAKR 178
Cdd:pfam07529   10 THHDYLLEEILWHSKDFKQERRWKRARAKKLARAVAQYHK-------NIEKEEQKRIEREEKQ 65
 
Name Accession Description Interval E-value
DEXQc_SRCAP cd18003
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ...
 447-679 1.52e-155

DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350761 [Multi-domain]  Cd Length: 223  Bit Score: 465.29  E-value: 1.52e-155
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  447 LREYQQYGLEWLTALHDSNTNGILADEMGLGKTIQTIALLAHLACEKENWGPHLIIVPTSVMLNWEMEFKKFLPGFKILT 526
Cdd:cd18003      1 LREYQHIGLDWLATLYEKNLNGILADEMGLGKTIQTIALLAHLACEKGNWGPHLIVVPTSVMLNWEMEFKRWCPGFKILT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  527 YYGNPQERKEKRSGWYKPDTWHVCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKNFRSQRWQSLLNFNAEHRLLLTGTP 606
Cdd:cd18003     81 YYGSAKERKLKRQGWMKPNSFHVCITSYQLVVQDHQVFKRKKWKYLILDEAHNIKNFKSQRWQTLLNFNTQRRLLLTGTP 160

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1246742950  607 LQNNLVELWSLLYFLMPagvtqnnSAFANLKDFQDWFSKPMDRLIEEGQDmnpEAMNTVAKLHRVLRPYLLRR 679
Cdd:cd18003    161 LQNSLMELWSLMHFLMP-------HIFQSHQEFKEWFSNPLTAMSEGSQE---ENEELVRRLHKVLRPFLLRR 223
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 432-1134 5.96e-111

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 364.16  E-value: 5.96e-111
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  432 LHANKIQVPFLFRGTLREYQQYGLEWLTALHDSNTNGILADEMGLGKTIQTIALLAHLAcEKENWGPHLIIVPTSVMLNW 511
Cdd:COG0553    227 LREALESLPAGLKATLRPYQLEGAAWLLFLRRLGLGGLLADDMGLGKTIQALALLLELK-ERGLARPVLIVAPTSLVGNW 305

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  512 EMEFKKFLPGFKILTYYGnPQERKEKRSGWYKPDtwhVCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKNFRSQRWQSL 591
Cdd:COG0553    306 QRELAKFAPGLRVLVLDG-TRERAKGANPFEDAD---LVITSYGLLRRDIELLAAVDWDLVILDEAQHIKNPATKRAKAV 381

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  592 LNFNAEHRLLLTGTPLQNNLVELWSLLYFLMPaGVtqnnsaFANLKDFQDWFSKPmdrlIEEGqdmNPEAMntvAKLHRV 671
Cdd:COG0553    382 RALKARHRLALTGTPVENRLEELWSLLDFLNP-GL------LGSLKAFRERFARP----IEKG---DEEAL---ERLRRL 444

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  672 LRPYLLRRLKTEVEKQMPAKYEHVVYCQLSKRQRFLYDDFINRARtREILASGNF---MSIINCLMQLRKVCNHPnlhee 748
Cdd:COG0553    445 LRPFLLRRTKEDVLKDLPEKTEETLYVELTPEQRALYEAVLEYLR-RELEGAEGIrrrGLILAALTRLRQICSHP----- 518

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  749 rpivtsfalrrsAIADLEIKDLLVRKrllheepmTKLDlstlrlirtdseafdtfvsdelnslcatnaynristflrmqi 828
Cdd:COG0553    519 ------------ALLLEEGAELSGRS--------AKLE------------------------------------------ 536

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  829 deeckpcqfkksnfkehfqnkiyqeqldklnfqkylneskcshspiygsnliRLAEKLpkhstsidytlyakddplylln 908
Cdd:COG0553    537 ----------------------------------------------------ALLELL---------------------- 542

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  909 ttkalrscilsTEERASNMKeiiqrfacitpkaVVVdlpelFCktiprdllyevsrkinplhqastrlaiafpdkrllQY 988
Cdd:COG0553    543 -----------EELLAEGEK-------------VLV-----FS-----------------------------------QF 558

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  989 dcgkLQVLDRLLKDLVSNGHRVLIFtqmtkvldileqflnihghrylrlDGATKIEQRQILTERFNNDDKIPVFILSTRS 1068
Cdd:COG0553    559 ----TDTLDLLEERLEERGIEYAYL------------------------HGGTSAEERDELVDRFQEGPEAPVFLISLKA 610

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1246742950 1069 GGLGINLTGADTVIFYDSDWNPQLDAQAQDRSHRIGQTRDVHIYRLISEYTVESNMLRRANQKRML 1134
Cdd:COG0553    611 GGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRAL 676
SNF2-rel_dom pfam00176
SNF2-related domain; This domain is found in proteins involved in a variety of processes ...
 450-745 4.36e-87

SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.


Pssm-ID: 425504 [Multi-domain]  Cd Length: 289  Bit Score: 284.58  E-value: 4.36e-87
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  450 YQQYGLEWLTALH-DSNTNGILADEMGLGKTIQTIALLAHLACEKENWG-PHLIIVPTSVMLNWEMEFKKFL--PGFKIL 525
Cdd:pfam00176    1 YQIEGVNWMLSLEnNLGRGGILADEMGLGKTLQTISLLLYLKHVDKNWGgPTLIVVPLSLLHNWMNEFERWVspPALRVV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  526 TYYGNPQERKEKRSGWYKPDTWHVCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKNFRSQRWQSLLNFNAEHRLLLTGT 605
Cdd:pfam00176   81 VLHGNKRPQERWKNDPNFLADFDVVITTYETLRKHKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWILTGT 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  606 PLQNNLVELWSLLYFLMPagvtqnnSAFANLKDFQDWFSKPMdrlieegqdMNPEAMNTVAKLHRVLRPYLLRRLKTEVE 685
Cdd:pfam00176  161 PLQNNLEELWALLNFLRP-------GPFGSLSTFRNWFDRPI---------ERGGGKKGVSRLHKLLKPFLLRRTKKDVE 224

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1246742950  686 KQMPAKYEHVVYCQLSKRQRFLYDDFINRARTREILAS----GNFMSIINCLMQLRKVCNHPNL 745
Cdd:pfam00176  225 KSLPPKVEYILFCRLSKLQRKLYQTFLLKKDLNAIKTGeggrEIKASLLNILMRLRKICNHPGL 288
DEXQc_INO80 cd18002
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ...
 447-679 1.78e-85

DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350760 [Multi-domain]  Cd Length: 229  Bit Score: 277.85  E-value: 1.78e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  447 LREYQQYGLEWLTALHDSNTNGILADEMGLGKTIQTIALLAHLACEKENWGPHLIIVPTSVMLNWEMEFKKFLPGFKILT 526
Cdd:cd18002      1 LKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSIAVLAHLAEEHNIWGPFLVIAPASTLHNWQQEISRFVPQFKVLP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  527 YYGNPQERKEKRSGW------YKPDTWHVCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKNFRSQRWQSLLNFNAEHRL 600
Cdd:cd18002     81 YWGNPKDRKVLRKFWdrknlyTRDAPFHVVITSYQLVVQDEKYFQRVKWQYMVLDEAQAIKSSSSSRWKTLLSFHCRNRL 160

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1246742950  601 LLTGTPLQNNLVELWSLLYFLMPagvtqnnSAFANLKDFQDWFSKPMDRLIEEGQDMNPEAMNtvaKLHRVLRPYLLRR 679
Cdd:cd18002    161 LLTGTPIQNSMAELWALLHFIMP-------TLFDSHDEFNEWFSKDIESHAENKTGLNEHQLK---RLHMILKPFMLRR 229
DEXHc_SMARCA2_SMARCA4 cd17996
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ...
 445-681 2.31e-82

DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350754 [Multi-domain]  Cd Length: 233  Bit Score: 269.24  E-value: 2.31e-82
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  445 GTLREYQQYGLEWLTALHDSNTNGILADEMGLGKTIQTIALLAHLACEKENWGPHLIIVPTSVMLNWEMEFKKFLPGFKI 524
Cdd:cd17996      2 GTLKEYQLKGLQWMVSLYNNNLNGILADEMGLGKTIQTISLITYLMEKKKNNGPYLVIVPLSTLSNWVSEFEKWAPSVSK 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  525 LTYYGNPQERKEKRSGwYKPDTWHVCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKNFRSQRWQSLLN-FNAEHRLLLT 603
Cdd:cd17996     82 IVYKGTPDVRKKLQSQ-IRAGKFNVLLTTYEYIIKDKPLLSKIKWKYMIIDEGHRMKNAQSKLTQTLNTyYHARYRLLLT 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  604 GTPLQNNLVELWSLLYFLMPagvtqnnSAFANLKDFQDWFSKPM--------DRLIEEgqdmnpEAMNTVAKLHRVLRPY 675
Cdd:cd17996    161 GTPLQNNLPELWALLNFLLP-------KIFKSCKTFEQWFNTPFantgeqvkIELNEE------ETLLIIRRLHKVLRPF 227


                   ....*.
gi 1246742950  676 LLRRLK 681
Cdd:cd17996    228 LLRRLK 233
DEXHc_Snf cd17919
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ...
 447-623 7.74e-80

DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350677 [Multi-domain]  Cd Length: 182  Bit Score: 259.81  E-value: 7.74e-80
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  447 LREYQQYGLEWLTALHDSNTNGILADEMGLGKTIQTIALLAHLACEKENWGPHLIIVPTSVMLNWEMEFKKFLPGFKILT 526
Cdd:cd17919      1 LRPYQLEGLNFLLELYENGPGGILADEMGLGKTLQAIAFLAYLLKEGKERGPVLVVCPLSVLENWEREFEKWTPDLRVVV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  527 YYGNPQERKEKRSGWYKPDTwHVCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKNFRSQRWQSLLNFNAEHRLLLTGTP 606
Cdd:cd17919     81 YHGSQRERAQIRAKEKLDKF-DVVLTTYETLRRDKASLRKFRWDLVVVDEAHRLKNPKSQLSKALKALRAKRRLLLTGTP 159

                          170
                   ....*....|....*..
gi 1246742950  607 LQNNLVELWSLLYFLMP 623
Cdd:cd17919    160 LQNNLEELWALLDFLDP 176
DEXHc_SMARCA1_SMARCA5 cd17997
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ...
 445-681 1.52e-79

DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350755 [Multi-domain]  Cd Length: 222  Bit Score: 260.72  E-value: 1.52e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  445 GTLREYQQYGLEWLTALHDSNTNGILADEMGLGKTIQTIALLAHLACEKENWGPHLIIVPTSVMLNWEMEFKKFLPGFKI 524
Cdd:cd17997      2 GTMRDYQIRGLNWLISLFENGINGILADEMGLGKTLQTISLLGYLKHYKNINGPHLIIVPKSTLDNWMREFKRWCPSLRV 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  525 LTYYGNPQERKEKRSGWYKPDTWHVCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKNFRSQRWQSLLNFNAEHRLLLTG 604
Cdd:cd17997     82 VVLIGDKEERADIIRDVLLPGKFDVCITSYEMVIKEKTVLKKFNWRYIIIDEAHRIKNEKSKLSQIVRLFNSRNRLLLTG 161

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1246742950  605 TPLQNNLVELWSLLYFLMPagvtqnnSAFANLKDFQDWFskpmdrlieEGQDMNPEAMNTVAKLHRVLRPYLLRRLK 681
Cdd:cd17997    162 TPLQNNLHELWALLNFLLP-------DVFTSSEDFDEWF---------NVNNCDDDNQEVVQRLHKVLRPFLLRRIK 222
DEXQc_arch_SWI2_SNF2 cd18012
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ...
 443-681 2.99e-77

DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350770 [Multi-domain]  Cd Length: 218  Bit Score: 254.03  E-value: 2.99e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  443 FRGTLREYQQYGLEWLTALHDSNTNGILADEMGLGKTIQTIALLAHLAcEKENWGPHLIIVPTSVMLNWEMEFKKFLPGF 522
Cdd:cd18012      1 LKATLRPYQKEGFNWLSFLRHYGLGGILADDMGLGKTLQTLALLLSRK-EEGRKGPSLVVAPTSLIYNWEEEAAKFAPEL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  523 KILTYYGNPQERKEKRSgWYKPDtwhVCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKNFRSQRWQSLLNFNAEHRLLL 602
Cdd:cd18012     80 KVLVIHGTKRKREKLRA-LEDYD---LVITSYGLLRRDIELLKEVKFHYLVLDEAQNIKNPQTKTAKAVKALKADHRLAL 155

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1246742950  603 TGTPLQNNLVELWSLLYFLMPaGVtqnnsaFANLKDFQDWFSKPmdrlIEEGQDmnPEAMntvAKLHRVLRPYLLRRLK 681
Cdd:cd18012    156 TGTPIENHLGELWSIFDFLNP-GL------LGSYKRFKKRFAKP----IEKDGD--EEAL---EELKKLISPFILRRLK 218
DEXHc_HELLS_SMARCA6 cd18009
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ...
 445-681 9.86e-77

DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350767 [Multi-domain]  Cd Length: 236  Bit Score: 253.46  E-value: 9.86e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  445 GTLREYQQYGLEWLTALHDSNTNGILADEMGLGKTIQTIALLAHLAcEKENWGPHLIIVPTSVMLNWEMEFKKFLPGFKI 524
Cdd:cd18009      2 GVMRPYQLEGMEWLRMLWENGINGILADEMGLGKTIQTIALLAHLR-ERGVWGPFLVIAPLSTLPNWVNEFARFTPSVPV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  525 LTYYGNPQERKEKRSGWYKPDTWH----VCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKNFRSQRWQSLLNFNAEHRL 600
Cdd:cd18009     81 LLYHGTKEERERLRKKIMKREGTLqdfpVVVTSYEIAMRDRKALQHYAWKYLIVDEGHRLKNLNCRLIQELKTFNSDNRL 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  601 LLTGTPLQNNLVELWSLLYFLMPagvtqnnSAFANLKDFQDWF--SKPMDRLIEEGQDMNPEAMNTVAKLHRVLRPYLLR 678
Cdd:cd18009    161 LLTGTPLQNNLSELWSLLNFLLP-------DVFDDLSSFESWFdfSSLSDNAADISNLSEEREQNIVHMLHAILKPFLLR 233


                   ...
gi 1246742950  679 RLK 681
Cdd:cd18009    234 RLK 236
PLN03142 PLN03142
Probable chromatin-remodeling complex ATPase chain; Provisional
 424-745 5.12e-75

Probable chromatin-remodeling complex ATPase chain; Provisional


Pssm-ID: 215601 [Multi-domain]  Cd Length: 1033  Bit Score: 270.90  E-value: 5.12e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  424 DEPNGSPVLHANKIQV-PFLFRGTLREYQQYGLEWLTALHDSNTNGILADEMGLGKTIQTIALLAHLACEKENWGPHLII 502
Cdd:PLN03142   146 EEEDGLGGSGGTRLLVqPSCIKGKMRDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLGYLHEYRGITGPHMVV 225

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  503 VPTSVMLNWEMEFKKFLPGFKILTYYGNPQERKEKRSGWYKPDTWHVCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKN 582
Cdd:PLN03142   226 APKSTLGNWMNEIRRFCPVLRAVKFHGNPEERAHQREELLVAGKFDVCVTSFEMAIKEKTALKRFSWRYIIIDEAHRIKN 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  583 FRSQRWQSLLNFNAEHRLLLTGTPLQNNLVELWSLLYFLMPagvtqnnSAFANLKDFQDWFSKpmdrlieEGQDMNPEam 662
Cdd:PLN03142   306 ENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLP-------EIFSSAETFDEWFQI-------SGENDQQE-- 369

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  663 nTVAKLHRVLRPYLLRRLKTEVEKQMPAKYEHVVYCQLSKRQRFLYD-------DFINRARTREILasgnfmsiINCLMQ 735
Cdd:PLN03142   370 -VVQQLHKVLRPFLLRRLKSDVEKGLPPKKETILKVGMSQMQKQYYKallqkdlDVVNAGGERKRL--------LNIAMQ 440

                          330
                   ....*....|
gi 1246742950  736 LRKVCNHPNL 745
Cdd:PLN03142   441 LRKCCNHPYL 450
DEXHc_CHD1_2 cd17993
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ...
 446-679 8.62e-66

DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350751 [Multi-domain]  Cd Length: 218  Bit Score: 221.85  E-value: 8.62e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  446 TLREYQQYGLEWLTALHDSNTNGILADEMGLGKTIQTIALLAHLACEKENWGPHLIIVPTSVMLNWEMEFKKFLPGFKIL 525
Cdd:cd17993      1 ELRDYQLTGLNWLAHSWCKGNNGILADEMGLGKTVQTISFLSYLFHSQQQYGPFLVVVPLSTMPAWQREFAKWAPDMNVI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  526 TYYGNPQERKEKRS-GWYKPDT----WHVCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKNFRSQRWQSLLNFNAEHRL 600
Cdd:cd17993     81 VYLGDIKSRDTIREyEFYFSQTkklkFNVLLTTYEIILKDKAFLGSIKWQYLAVDEAHRLKNDESLLYEALKEFKTNNRL 160

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1246742950  601 LLTGTPLQNNLVELWSLLYFLMPagvtqnnSAFANLKDFQDwfskpmdrlieegqDMNPEAMNTVAKLHRVLRPYLLRR 679
Cdd:cd17993    161 LITGTPLQNSLKELWALLHFLMP-------GKFDIWEEFEE--------------EHDEEQEKGIADLHKELEPFILRR 218
DEXHc_SMARCAD1 cd17998
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ...
 447-623 3.81e-65

DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350756 [Multi-domain]  Cd Length: 187  Bit Score: 218.41  E-value: 3.81e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  447 LREYQQYGLEWLTALHDSNTNGILADEMGLGKTIQTIALLAHLAcEKENWGPHLIIVPTSVMLNWEMEFKKFLPGFKILT 526
Cdd:cd17998      1 LKDYQLIGLNWLNLLYQKKLSGILADEMGLGKTIQVIAFLAYLK-EIGIPGPHLVVVPSSTLDNWLREFKRWCPSLKVEP 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  527 YYGNPQERKEKRSGWYKP-DTWHVCITSYQLVL---QDHQPFRRKKWQYMILDEAHNIKNFRSQRWQSLLNFNAEHRLLL 602
Cdd:cd17998     80 YYGSQEERKHLRYDILKGlEDFDVIVTTYNLATsnpDDRSFFKRLKLNYVVYDEGHMLKNMTSERYRHLMTINANFRLLL 159

                          170       180
                   ....*....|....*....|.
gi 1246742950  603 TGTPLQNNLVELWSLLYFLMP 623
Cdd:cd17998    160 TGTPLQNNLLELMSLLNFIMP 180
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
 980-1115 4.46e-63

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 210.41  E-value: 4.46e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  980 FPDKRLLQYDcGKLQVLDRLLKDLVSNGHRVLIFTQMTKVLDILEQFLNIHGHRYLRLDGATKIEQRQILTERFNNDDKI 1059
Cdd:cd18793      1 LPPKIEEVVS-GKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDI 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1246742950 1060 PVFILSTRSGGLGINLTGADTVIFYDSDWNPQLDAQAQDRSHRIGQTRDVHIYRLI 1115
Cdd:cd18793     80 RVFLLSTKAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
DEXHc_SMARCA5 cd18064
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ...
 445-691 1.95e-60

DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350822 [Multi-domain]  Cd Length: 244  Bit Score: 207.60  E-value: 1.95e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  445 GTLREYQQYGLEWLTALHDSNTNGILADEMGLGKTIQTIALLAHLACEKENWGPHLIIVPTSVMLNWEMEFKKFLPGFKI 524
Cdd:cd18064     14 GKLRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKHYRNIPGPHMVLVPKSTLHNWMAEFKRWVPTLRA 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  525 LTYYGNPQERKEKRSGWYKPDTWHVCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKNFRSQRWQSLLNFNAEHRLLLTG 604
Cdd:cd18064     94 VCLIGDKDQRAAFVRDVLLPGEWDVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTG 173

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  605 TPLQNNLVELWSLLYFLMPagvtqnnSAFANLKDFQDWFskpmdrliEEGQDMNPEAMntVAKLHRVLRPYLLRRLKTEV 684
Cdd:cd18064    174 TPLQNNLHELWALLNFLLP-------DVFNSAEDFDSWF--------DTNNCLGDQKL--VERLHMVLRPFLLRRIKADV 236


                   ....*..
gi 1246742950  685 EKQMPAK 691
Cdd:cd18064    237 EKSLPPK 243
DEXHc_CHD6_7_8_9 cd17995
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ...
 447-679 1.80e-59

DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350753 [Multi-domain]  Cd Length: 223  Bit Score: 203.63  E-value: 1.80e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  447 LREYQQYGLEWLTALHDSNTNGILADEMGLGKTIQTIALLAHLACEKENWGPHLIIVPTSVMLNWEMEFKKFLPgFKILT 526
Cdd:cd17995      1 LRDYQLEGVNWLLFNWYNRRNCILADEMGLGKTIQSIAFLEHLYQVEGIRGPFLVIAPLSTIPNWQREFETWTD-MNVVV 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  527 YYGNpQERKEKRSG--WYKPDTW----------HVCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKNFRSQRWQSLLNF 594
Cdd:cd17995     80 YHGS-GESRQIIQQyeMYFKDAQgrkkkgvykfDVLITTYEMVIADAEELRKIPWRVVVVDEAHRLKNRNSKLLQGLKKL 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  595 NAEHRLLLTGTPLQNNLVELWSLLYFLMPagvtqnnSAFANLKDFQDWFSKpmdrLIEEGQdmnpeamntVAKLHRVLRP 674
Cdd:cd17995    159 TLEHKLLLTGTPLQNNTEELWSLLNFLEP-------EKFPSSEEFLEEFGD----LKTAEQ---------VEKLQALLKP 218


                   ....*
gi 1246742950  675 YLLRR 679
Cdd:cd17995    219 YMLRR 223
DEXHc_SMARCA2 cd18063
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ...
 438-681 1.75e-57

DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350821 [Multi-domain]  Cd Length: 251  Bit Score: 199.13  E-value: 1.75e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  438 QVPFLFRGTLREYQQYGLEWLTALHDSNTNGILADEMGLGKTIQTIALLAHLACEKENWGPHLIIVPTSVMLNWEMEFKK 517
Cdd:cd18063     15 QSSLLINGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIVPLSTLSNWTYEFDK 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  518 FLPGFKILTYYGNPQERK----EKRSGwykpdTWHVCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKNFRSQRWQSL-L 592
Cdd:cd18063     95 WAPSVVKISYKGTPAMRRslvpQLRSG-----KFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLnT 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  593 NFNAEHRLLLTGTPLQNNLVELWSLLYFLMPagvtqnnSAFANLKDFQDWFSKPMdRLIEEGQDMN-PEAMNTVAKLHRV 671
Cdd:cd18063    170 HYVAPRRILLTGTPLQNKLPELWALLNFLLP-------TIFKSCSTFEQWFNAPF-AMTGERVDLNeEETILIIRRLHKV 241

                          250
                   ....*....|
gi 1246742950  672 LRPYLLRRLK 681
Cdd:cd18063    242 LRPFLLRRLK 251
DEXHc_SMARCA1 cd18065
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ...
 445-681 2.25e-57

DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350823 [Multi-domain]  Cd Length: 233  Bit Score: 198.32  E-value: 2.25e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  445 GTLREYQQYGLEWLTALHDSNTNGILADEMGLGKTIQTIALLAHLACEKENWGPHLIIVPTSVMLNWEMEFKKFLPGFKI 524
Cdd:cd18065     14 GTLRDYQVRGLNWMISLYENGVNGILADEMGLGKTLQTIALLGYLKHYRNIPGPHMVLVPKSTLHNWMNEFKRWVPSLRA 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  525 LTYYGNPQERKEKRSGWYKPDTWHVCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKNFRSQRWQSLLNFNAEHRLLLTG 604
Cdd:cd18065     94 VCLIGDKDARAAFIRDVMMPGEWDVCVTSYEMVIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTG 173

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1246742950  605 TPLQNNLVELWSLLYFLMPagvtqnnSAFANLKDFQDWFskpmdrliEEGQDMNPEAMntVAKLHRVLRPYLLRRLK 681
Cdd:cd18065    174 TPLQNNLHELWALLNFLLP-------DVFNSADDFDSWF--------DTKNCLGDQKL--VERLHAVLKPFLLRRIK 233
DEXHc_SMARCA4 cd18062
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ...
 438-681 3.91e-57

DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350820 [Multi-domain]  Cd Length: 251  Bit Score: 198.34  E-value: 3.91e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  438 QVPFLFRGTLREYQQYGLEWLTALHDSNTNGILADEMGLGKTIQTIALLAHLACEKENWGPHLIIVPTSVMLNWEMEFKK 517
Cdd:cd18062     15 QSSLLVNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTLSNWVYEFDK 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  518 FLPGFKILTYYGNPQERK----EKRSGwykpdTWHVCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKNFRSQRWQSL-L 592
Cdd:cd18062     95 WAPSVVKVSYKGSPAARRafvpQLRSG-----KFNVLLTTYEYIIKDKQILAKIRWKYMIVDEGHRMKNHHCKLTQVLnT 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  593 NFNAEHRLLLTGTPLQNNLVELWSLLYFLMPagvtqnnSAFANLKDFQDWFSKPMdRLIEEGQDMN-PEAMNTVAKLHRV 671
Cdd:cd18062    170 HYVAPRRLLLTGTPLQNKLPELWALLNFLLP-------TIFKSCSTFEQWFNAPF-AMTGEKVDLNeEETILIIRRLHKV 241

                          250
                   ....*....|
gi 1246742950  672 LRPYLLRRLK 681
Cdd:cd18062    242 LRPFLLRRLK 251
DEXHc_Mot1 cd17999
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ...
 447-679 4.95e-57

DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350757 [Multi-domain]  Cd Length: 232  Bit Score: 197.19  E-value: 4.95e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  447 LREYQQYGLEWLTALHDSNTNGILADEMGLGKTIQTIALLAHLACEKENWG-----PHLIIVPTSVMLNWEMEFKKFLPG 521
Cdd:cd17999      1 LRPYQQEGINWLAFLNKYNLHGILCDDMGLGKTLQTLCILASDHHKRANSFnsenlPSLVVCPPTLVGHWVAEIKKYFPN 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  522 F--KILTYYGNPQERKEKRSGWYKPDtwhVCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKNFRSQRWQSLLNFNAEHR 599
Cdd:cd17999     81 AflKPLAYVGPPQERRRLREQGEKHN---VIVASYDVLRNDIEVLTKIEWNYCVLDEGHIIKNSKTKLSKAVKQLKANHR 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  600 LLLTGTPLQNNLVELWSLLYFLMPAgvtqnnsAFANLKDFQDWFSKPmdrlIEEGQDMNPEAMNTVA------KLHRVLR 673
Cdd:cd17999    158 LILSGTPIQNNVLELWSLFDFLMPG-------YLGTEKQFQRRFLKP----ILASRDSKASAKEQEAgalaleALHKQVL 226


                   ....*.
gi 1246742950  674 PYLLRR 679
Cdd:cd17999    227 PFLLRR 232
DEXHc_CHD1L cd18006
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ...
 447-679 9.67e-56

DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350764 [Multi-domain]  Cd Length: 216  Bit Score: 193.04  E-value: 9.67e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  447 LREYQQYGLEWLTALHDSNTNGILADEMGLGKTIQTIALLAHLACEKENWGPHLIIVPTSVMLNWEMEFKKFLPGFKILT 526
Cdd:cd18006      1 LRPYQLEGVNWLLQCRAEQHGCILGDEMGLGKTCQTISLLWYLAGRLKLLGPFLVLCPLSVLDNWKEELNRFAPDLSVIT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  527 YYGNPQERKEKRSGWYKPDTWHVCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKNFRSQRWQSLLNFNAEHRLLLTGTP 606
Cdd:cd18006     81 YMGDKEKRLDLQQDIKSTNRFHVLLTTYEICLKDASFLKSFPWASLVVDEAHRLKNQNSLLHKTLSEFSVDFRLLLTGTP 160

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1246742950  607 LQNNLVELWSLLYFLMPagvtqnnsafanlkdfqDWFSKP-MDRLIEEGQDMNPEAmNTVAKLHRVLRPYLLRR 679
Cdd:cd18006    161 IQNSLQELYALLSFIEP-----------------NVFPKDkLDDFIKAYSETDDES-ETVEELHLLLQPFLLRR 216
DEXHc_CHD2 cd18054
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ...
 447-679 1.48e-54

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350812 [Multi-domain]  Cd Length: 237  Bit Score: 190.22  E-value: 1.48e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  447 LREYQQYGLEWLTALHDSNTNGILADEMGLGKTIQTIALLAHLACEKENWGPHLIIVPTSVMLNWEMEFKKFLPGFKILT 526
Cdd:cd18054     21 LRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLLVVPLSTLTSWQREFEIWAPEINVVV 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  527 YYGNPQERKEKRS-GWYKPDT----WHVCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKNFRSQRWQSLLNFNAEHRLL 601
Cdd:cd18054    101 YIGDLMSRNTIREyEWIHSQTkrlkFNALITTYEILLKDKTVLGSINWAFLGVDEAHRLKNDDSLLYKTLIDFKSNHRLL 180

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1246742950  602 LTGTPLQNNLVELWSLLYFLMPagvtqnnSAFANLKDFQDWFSKpmdrlieeGQDmnpeamNTVAKLHRVLRPYLLRR 679
Cdd:cd18054    181 ITGTPLQNSLKELWSLLHFIMP-------EKFEFWEDFEEDHGK--------GRE------NGYQSLHKVLEPFLLRR 237
DEXHc_ERCC6L cd18001
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ...
 447-679 9.24e-50

DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350759 [Multi-domain]  Cd Length: 232  Bit Score: 176.41  E-value: 9.24e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  447 LREYQQYGLEWLTALHDSNTNGILADEMGLGKTIQTIALLAHLAcEKENWGPHLIIVPTSVMLNWEMEFKKFLPGFKILT 526
Cdd:cd18001      1 LYPHQREGVAWLWSLHDGGKGGILADDMGLGKTVQICAFLSGMF-DSGLIKSVLVVMPTSLIPHWVKEFAKWTPGLRVKV 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  527 YYG-NPQERKE------KRSGwykpdtwhVCITSYQLVLQDHQPF-----RRKKWQYMILDEAHNIKNFRSQRWQSLLNF 594
Cdd:cd18001     80 FHGtSKKERERnleriqRGGG--------VLLTTYGMVLSNTEQLsaddhDEFKWDYVILDEGHKIKNSKTKSAKSLREI 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  595 NAEHRLLLTGTPLQNNLVELWSLLYFLMPAgvtqnnSAFANLKDFQDWFSKPmdrlIEEGQDMNPEAM-----NTVAK-L 668
Cdd:cd18001    152 PAKNRIILTGTPIQNNLKELWALFDFACNG------SLLGTRKTFKMEFENP----ITRGRDKDATQGekalgSEVAEnL 221

                          250
                   ....*....|.
gi 1246742950  669 HRVLRPYLLRR 679
Cdd:cd18001    222 RQIIKPYFLRR 232
DEXHc_ERCC6 cd18000
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ...
 447-623 1.00e-49

DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350758 [Multi-domain]  Cd Length: 193  Bit Score: 174.82  E-value: 1.00e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  447 LREYQQYGLEWLTALHDSNTNGILADEMGLGKTIQTIALLAHLACEKENWGPHLIIVPTSVMLNWEMEFKKFLPGFKILT 526
Cdd:cd18000      1 LFKYQQTGVQWLWELHCQRVGGILGDEMGLGKTIQIIAFLAALHHSKLGLGPSLIVCPATVLKQWVKEFHRWWPPFRVVV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  527 YY----GNPQERKEKRSGWYKP------DTWHVCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKNFRSQRWQSLLNFNA 596
Cdd:cd18000     81 LHssgsGTGSEEKLGSIERKSQlirkvvGDGGILITTYEGFRKHKDLLLNHNWQYVILDEGHKIRNPDAEITLACKQLRT 160

                          170       180
                   ....*....|....*....|....*..
gi 1246742950  597 EHRLLLTGTPLQNNLVELWSLLYFLMP 623
Cdd:cd18000    161 PHRLILSGTPIQNNLKELWSLFDFVFP 187
DEXHc_CHD3_4_5 cd17994
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ...
 447-679 2.49e-48

DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350752 [Multi-domain]  Cd Length: 196  Bit Score: 170.70  E-value: 2.49e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  447 LREYQQYGLEWLTALHDSNTNGILADEMGLGKTIQTIALLAHLACEKENWGPHLIIVPTSVMLNWEMEFKKFLPGFKILT 526
Cdd:cd17994      1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDFYVVT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  527 YYGNpqerkekrsgwykpdtwHVCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKNFRSQRWQSLLNFNAEHRLLLTGTP 606
Cdd:cd17994     81 YVGD-----------------HVLLTSYELISIDQAILGSIDWAVLVVDEAHRLKNNQSKFFRILNSYKIGYKLLLTGTP 143

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1246742950  607 LQNNLVELWSLLYFLMPagvtqnnSAFANLKDFQDWFSkpmdrlieegqDMNPEamNTVAKLHRVLRPYLLRR 679
Cdd:cd17994    144 LQNNLEELFHLLNFLTP-------ERFNNLQGFLEEFA-----------DISKE--DQIKKLHDLLGPHMLRR 196
PLN03142 PLN03142
Probable chromatin-remodeling complex ATPase chain; Provisional
 991-1145 1.09e-47

Probable chromatin-remodeling complex ATPase chain; Provisional


Pssm-ID: 215601 [Multi-domain]  Cd Length: 1033  Bit Score: 186.16  E-value: 1.09e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  991 GKLQVLDRLLKDLVSNGHRVLIFTQMTKVLDILEQFLNIHGHRYLRLDGATKIEQRQILTERFN--NDDKIpVFILSTRS 1068
Cdd:PLN03142   471 GKMVLLDKLLPKLKERDSRVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNkpGSEKF-VFLLSTRA 549

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1246742950 1069 GGLGINLTGADTVIFYDSDWNPQLDAQAQDRSHRIGQTRDVHIYRLISEYTVESNMLRRANQKRMLDKIVIQGGEFT 1145
Cdd:PLN03142   550 GGLGINLATADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKLALDALVIQQGRLA 626
DEXDc_SHPRH-like cd18008
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ...
 447-679 5.48e-45

DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350766 [Multi-domain]  Cd Length: 241  Bit Score: 162.84  E-value: 5.48e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  447 LREYQQYGLEWLTAlhdsnTNGILADEMGLGKTIQTIAL-LAHLACEKENWGPH----------------LIIVPTSVML 509
Cdd:cd18008      1 LLPYQKQGLAWMLP-----RGGILADEMGLGKTIQALALiLATRPQDPKIPEELeenssdpkklylskttLIVVPLSLLS 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  510 NWEMEFKKFL--PGFKILTYYGnpQERKEKRSGWYKPDtwhVCITSYQLVLQDHQ----------------PFRRKKWQY 571
Cdd:cd18008     76 QWKDEIEKHTkpGSLKVYVYHG--SKRIKSIEELSDYD---IVITTYGTLASEFPknkkgggrdskekeasPLHRIRWYR 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  572 MILDEAHNIKNFRSQRWQSLLNFNAEHRLLLTGTPLQNNLVELWSLLYFLmpagvtqNNSAFANLKDFQDWFSKPMDRLI 651
Cdd:cd18008    151 VILDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRFL-------RVEPFGDYPWFNSDISKPFSKND 223

                          250       260
                   ....*....|....*....|....*...
gi 1246742950  652 EEGQDmnpeamntvaKLHRVLRPYLLRR 679
Cdd:cd18008    224 RKALE----------RLQALLKPILLRR 241
DEXHc_CHD1 cd18053
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ...
 447-679 6.16e-43

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350811 [Multi-domain]  Cd Length: 237  Bit Score: 156.75  E-value: 6.16e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  447 LREYQQYGLEWLTALHDSNTNGILADEMGLGKTIQTIALLAHLACEKENWGPHLIIVPTSVMLNWEMEFKKFLPGFKILT 526
Cdd:cd18053     21 LRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQLYGPFLLVVPLSTLTSWQREIQTWAPQMNAVV 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  527 YYGNPQERKEKRSG-WYKPDT----WHVCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKNFRSQRWQSLLNFNAEHRLL 601
Cdd:cd18053    101 YLGDINSRNMIRTHeWMHPQTkrlkFNILLTTYEILLKDKSFLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNHRLL 180

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1246742950  602 LTGTPLQNNLVELWSLLYFLMPagvtqnnSAFANLKDFQDWFSKPMDrlieegqdmnpeamNTVAKLHRVLRPYLLRR 679
Cdd:cd18053    181 ITGTPLQNSLKELWSLLHFIMP-------EKFSSWEDFEEEHGKGRE--------------YGYASLHKELEPFLLRR 237
DEXHc_ERCC6L2 cd18005
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ...
 447-679 9.51e-43

DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350763 [Multi-domain]  Cd Length: 245  Bit Score: 156.77  E-value: 9.51e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  447 LREYQQYGLEWLTALHDSNTNGILADEMGLGKTIQTIALLAHL------ACEKEN--------------WGPHLIIVPTS 506
Cdd:cd18005      1 LRDYQREGVEFMYDLYKNGRGGILGDDMGLGKTVQVIAFLAAVlgktgtRRDRENnrprfkkkppassaKKPVLIVAPLS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  507 VMLNWEMEFKKFlpG-FKILTYYGnpQERKEKRSGWYKPDTWHVCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKNFRS 585
Cdd:cd18005     81 VLYNWKDELDTW--GhFEVGVYHG--SRKDDELEGRLKAGRLEVVVTTYDTLRRCIDSLNSINWSAVIADEAHRIKNPKS 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  586 QRWQSLLNFNAEHRLLLTGTPLQNNLVELWSLLYFLMPAgvtqnnsAFANLKDFQDWFSKPmdrlIEEGQDMNP------ 659
Cdd:cd18005    157 KLTQAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVPG-------ALGSRSQFKKHFSEP----IKRGQRHTAtarelr 225

                          250       260
                   ....*....|....*....|
gi 1246742950  660 EAMNTVAKLHRVLRPYLLRR 679
Cdd:cd18005    226 LGRKRKQELAVKLSKFFLRR 245
DEXHc_CHD3 cd18055
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ...
 447-679 6.02e-42

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350813 [Multi-domain]  Cd Length: 232  Bit Score: 154.01  E-value: 6.02e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  447 LREYQQYGLEWLTALHDSNTNGILADEMGLGKTIQTIALLAHLACEKENWGPHLIIVPTSVMLNWEMEFKKFLPGFKILT 526
Cdd:cd18055      1 LHMYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHTKGPFLVSAPLSTIINWEREFQMWAPDFYVVT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  527 YYGNPQERKEKRSGWYK-------------------PDTWHVCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKNFRSQR 587
Cdd:cd18055     81 YTGDKDSRAIIRENEFSfddnavkggkkafkmkreaQVKFHVLLTSYELVTIDQAALGSIRWACLVVDEAHRLKNNQSKF 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  588 WQSLLNFNAEHRLLLTGTPLQNNLVELWSLLYFLMPagvtqnnSAFANLKDFqdwfskpmdrlIEEGQDMNPEamNTVAK 667
Cdd:cd18055    161 FRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTP-------ERFNNLEGF-----------LEEFADISKE--DQIKK 220

                          250
                   ....*....|..
gi 1246742950  668 LHRVLRPYLLRR 679
Cdd:cd18055    221 LHDLLGPHMLRR 232
DEXHc_ATRX-like cd18007
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ...
 447-655 2.11e-40

DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350765 [Multi-domain]  Cd Length: 239  Bit Score: 149.75  E-value: 2.11e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  447 LREYQQYGLEWL------TALHDSNTNG-ILADEMGLGKTIQTIALL-AHLACEKENWGPhLIIVPTSVMLNWEMEFKKF 518
Cdd:cd18007      1 LKPHQVEGVRFLwsnlvgTDVGSDEGGGcILAHTMGLGKTLQVITFLhTYLAAAPRRSRP-LVLCPASTLYNWEDEFKKW 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  519 LPGFKI--LTYYGNPQERKEKRSgWYKPDTWH----VCITSYQL---VLQDHQPFRRKKWQYM-----------ILDEAH 578
Cdd:cd18007     80 LPPDLRplLVLVSLSASKRADAR-LRKINKWHkeggVLLIGYELfrnLASNATTDPRLKQEFIaalldpgpdllVLDEGH 158

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1246742950  579 NIKNFRSQRWQSLLNFNAEHRLLLTGTPLQNNLVELWSLLYFLMPAgvtqnnsAFANLKDFQDWFSKPmdrlIEEGQ 655
Cdd:cd18007    159 RLKNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFARPK-------YLGTLKEFKKKFVKP----IEAGQ 224
DEXHc_CHD5 cd18057
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ...
 447-679 2.66e-40

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350815 [Multi-domain]  Cd Length: 232  Bit Score: 149.06  E-value: 2.66e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  447 LREYQQYGLEWLTALHDSNTNGILADEMGLGKTIQTIALLAHLACEKENWGPHLIIVPTSVMLNWEMEFKKFLPGFKILT 526
Cdd:cd18057      1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKGPYLVSAPLSTIINWEREFEMWAPDFYVVT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  527 YYGNPQERKEKRSGWYKPD-------------------TWHVCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKNFRSQR 587
Cdd:cd18057     81 YTGDKESRSVIRENEFSFEdnairsgkkvfrmkkeaqiKFHVLLTSYELITIDQAILGSIEWACLVVDEAHRLKNNQSKF 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  588 WQSLLNFNAEHRLLLTGTPLQNNLVELWSLLYFLMPagvtqnnSAFANLKDFqdwfskpmdrlIEEGQDMNPEamNTVAK 667
Cdd:cd18057    161 FRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTP-------ERFNNLEGF-----------LEEFADISKE--DQIKK 220

                          250
                   ....*....|..
gi 1246742950  668 LHRVLRPYLLRR 679
Cdd:cd18057    221 LHDLLGPHMLRR 232
DEXHc_RAD54 cd18004
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ...
 447-679 1.80e-39

DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350762 [Multi-domain]  Cd Length: 240  Bit Score: 147.05  E-value: 1.80e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  447 LREYQQYGLEWL----TALHDSNTNG-ILADEMGLGKTIQTIALLAHLACEKENWGPH----LIIVPTSVMLNWEMEFKK 517
Cdd:cd18004      1 LRPHQREGVQFLydclTGRRGYGGGGaILADEMGLGKTLQAIALVWTLLKQGPYGKPTakkaLIVCPSSLVGNWKAEFDK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  518 FLPG--FKILTYYGNPQERKEKRSGWYKPDTWHVCITSY-QLVLQDHQPFRRKKWQYMILDEAHNIKNFRSQRWQSLLNF 594
Cdd:cd18004     81 WLGLrrIKVVTADGNAKDVKASLDFFSSASTYPVLIISYeTLRRHAEKLSKKISIDLLICDEGHRLKNSESKTTKALNSL 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  595 NAEHRLLLTGTPLQNNLVELWSLLYFLMPagvtqnnSAFANLKDFQDWFSKPM---------DRLIEEGQDMNPEamntv 665
Cdd:cd18004    161 PCRRRLLLTGTPIQNDLDEFFALVDFVNP-------GILGSLASFRKVFEEPIlrsrdpdasEEDKELGAERSQE----- 228

                          250
                   ....*....|....
gi 1246742950  666 akLHRVLRPYLLRR 679
Cdd:cd18004    229 --LSELTSRFILRR 240
DEXHc_CHD4 cd18056
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ...
 447-679 1.61e-38

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350814 [Multi-domain]  Cd Length: 232  Bit Score: 144.05  E-value: 1.61e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  447 LREYQQYGLEWLTALHDSNTNGILADEMGLGKTIQTIALLAHLACEKENWGPHLIIVPTSVMLNWEMEFKKFLPGFKILT 526
Cdd:cd18056      1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDMYVVT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  527 YYGNPQER-------------------KEKRSGWYKPDTWHVCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKNFRSQR 587
Cdd:cd18056     81 YVGDKDSRaiirenefsfednairggkKASRMKKEASVKFHVLLTSYELITIDMAILGSIDWACLIVDEAHRLKNNQSKF 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  588 WQSLLNFNAEHRLLLTGTPLQNNLVELWSLLYFLMPagvtqnnSAFANLKDFqdwfskpmdrlIEEGQDMNPEamNTVAK 667
Cdd:cd18056    161 FRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTP-------ERFHNLEGF-----------LEEFADIAKE--DQIKK 220

                          250
                   ....*....|..
gi 1246742950  668 LHRVLRPYLLRR 679
Cdd:cd18056    221 LHDMLGPHMLRR 232
DEXHc_CHD8 cd18060
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ...
 447-679 1.34e-37

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350818 [Multi-domain]  Cd Length: 222  Bit Score: 140.96  E-value: 1.34e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  447 LREYQQYGLEWLTALHDSNTNGILADEMGLGKTIQTIALLAHLACEKENwGPHLIIVPTSVMLNWEMEFKKFLPgFKILT 526
Cdd:cd18060      1 LREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSIAFLQEVYNVGIH-GPFLVIAPLSTITNWEREFNTWTE-MNTIV 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  527 YYGNPQERK--EKRSGWYKPDTWHVC---------ITSYQLVLQDHQPFRRKKWQYMILDEAHNIKNFRSQRWQSLLNFN 595
Cdd:cd18060     79 YHGSLASRQmiQQYEMYCKDSRGRLIpgaykfdalITTFEMILSDCPELREIEWRCVIIDEAHRLKNRNCKLLDSLKHMD 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  596 AEHRLLLTGTPLQNNLVELWSLLYFLMPagvTQNNSAFANLKDFQDwfskpmdrLIEEGQdmnpeamntVAKLHRVLRPY 675
Cdd:cd18060    159 LEHKVLLTGTPLQNTVEELFSLLHFLEP---SQFPSESEFLKDFGD--------LKTEEQ---------VQKLQAILKPM 218


                   ....
gi 1246742950  676 LLRR 679
Cdd:cd18060    219 MLRR 222
DEXHc_CHD6 cd18058
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ...
 447-679 1.12e-36

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350816 [Multi-domain]  Cd Length: 222  Bit Score: 138.25  E-value: 1.12e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  447 LREYQQYGLEWLTALHDSNTNGILADEMGLGKTIQTIALLAHLACEKENwGPHLIIVPTSVMLNWEMEFKKFLPgFKILT 526
Cdd:cd18058      1 LREYQLEGMNWLLFNWYNRKNCILADEMGLGKTIQSITFLSEIFLMGIR-GPFLIIAPLSTITNWEREFRTWTE-MNAIV 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  527 YYGNPQERK--------------EKRSGWYKpdtWHVCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKNFRSQRWQSLL 592
Cdd:cd18058     79 YHGSQISRQmiqqyemyyrdeqgNPLSGIFK---FQVVITTFEMILADCPELKKINWSCVIIDEAHRLKNRNCKLLEGLK 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  593 NFNAEHRLLLTGTPLQNNLVELWSLLYFLMPagvtqnnSAFANLKDFqdwfskpmdrlIEEGQDMNPEamNTVAKLHRVL 672
Cdd:cd18058    156 LMALEHKVLLTGTPLQNSVEELFSLLNFLEP-------SQFPSETTF-----------LEEFGDLKTE--EQVKKLQSIL 215


                   ....*..
gi 1246742950  673 RPYLLRR 679
Cdd:cd18058    216 KPMMLRR 222
DEXHc_CHD7 cd18059
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ...
 447-679 3.65e-34

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350817 [Multi-domain]  Cd Length: 222  Bit Score: 131.31  E-value: 3.65e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  447 LREYQQYGLEWLTALHDSNTNGILADEMGLGKTIQTIALLAHLACeKENWGPHLIIVPTSVMLNWEMEFKKFLPgFKILT 526
Cdd:cd18059      1 LREYQLEGVNWLLFNWYNTRNCILADEMGLGKTIQSITFLYEIYL-KGIHGPFLVIAPLSTIPNWEREFRTWTE-LNVVV 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  527 YYGNPQERKEKRS--------------GWYKpdtWHVCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKNFRSQRWQSLL 592
Cdd:cd18059     79 YHGSQASRRTIQLyemyfkdpqgrvikGSYK---FHAIITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLK 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  593 NFNAEHRLLLTGTPLQNNLVELWSLLYFLMPaGVTQNNSAFanlkdfqdwfskpmdrlIEEGQDMNPEamNTVAKLHRVL 672
Cdd:cd18059    156 MMDLEHKVLLTGTPLQNTVEELFSLLHFLEP-SRFPSETTF-----------------MQEFGDLKTE--EQVQKLQAIL 215


                   ....*..
gi 1246742950  673 RPYLLRR 679
Cdd:cd18059    216 KPMMLRR 222
DEXHc_HARP_SMARCAL1 cd18010
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ...
 447-639 4.51e-31

DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350768 [Multi-domain]  Cd Length: 213  Bit Score: 121.93  E-value: 4.51e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  447 LREYQQYGLEWltALhDSNTNGILADEMGLGKTIQTIALLAHLaceKENWgPHLIIVPTSVMLNWEMEFKKFLPGFKIlt 526
Cdd:cd18010      1 LLPFQREGVCF--AL-RRGGRVLIADEMGLGKTVQAIAIAAYY---REEW-PLLIVCPSSLRLTWADEIERWLPSLPP-- 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  527 yygnPQERKEKRSGWYKPDTWH-VCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKNFRSQRWQSLLNF--NAEHRLLLT 603
Cdd:cd18010     72 ----DDIQVIVKSKDGLRDGDAkVVIVSYDLLRRLEKQLLARKFKVVICDESHYLKNSKAKRTKAALPLlkRAKRVILLS 147

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1246742950  604 GTPLQNNLVELWSLLYFLMPAgvtqnnsAFANLKDF 639
Cdd:cd18010    148 GTPALSRPIELFTQLDALDPK-------LFGRFHDF 176
DEXDc smart00487
DEAD-like helicases superfamily;
439-623 3.47e-30

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 118.75  E-value: 3.47e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950   439 VPFLFRGTLREYQQYGLEWLtalHDSNTNGILADEMGLGKTIQ-TIALLAHLAceKENWGPHLIIVPTSV-MLNWEMEFK 516
Cdd:smart00487    1 IEKFGFEPLRPYQKEAIEAL---LSGLRDVILAAPTGSGKTLAaLLPALEALK--RGKGGRVLVLVPTRElAEQWAEELK 75

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950   517 KFLP--GFKILTYYGNPQERKEKRSgWYKPDTwHVCITSYQLVLQD--HQPFRRKKWQYMILDEAHNIKNF-RSQRWQSL 591
Cdd:smart00487   76 KLGPslGLKVVGLYGGDSKREQLRK-LESGKT-DILVTTPGRLLDLleNDKLSLSNVDLVILDEAHRLLDGgFGDQLEKL 153

                           170       180       190
                    ....*....|....*....|....*....|....*..
gi 1246742950   592 LNF--NAEHRLLLTGTP---LQNNLVELWSLLYFLMP 623
Cdd:smart00487  154 LKLlpKNVQLLLLSATPpeeIENLLELFLNDPVFIDV 190
DEXHc_CHD9 cd18061
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ...
 447-679 4.11e-30

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350819 [Multi-domain]  Cd Length: 222  Bit Score: 119.34  E-value: 4.11e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  447 LREYQQYGLEWLTALHDSNTNGILADEMGLGKTIQTIALLAHLACEKENwGPHLIIVPTSVMLNWEMEFKKFlPGFKILT 526
Cdd:cd18061      1 LREYQLEGLNWLLFNWYNRRNCILADEMGLGKTIQSITFLYEILLTGIR-GPFLIIAPLSTIANWEREFRTW-TDLNVVV 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  527 YYGNPQERKE-KRSGWYKPDT----------WHVCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKNFRSQRWQSLLNFN 595
Cdd:cd18061     79 YHGSLISRQMiQQYEMYFRDSqgriirgayrFQAIITTFEMILGGCPELNAIDWRCVIIDEAHRLKNKNCKLLEGLKLMN 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  596 AEHRLLLTGTPLQNNLVELWSLLYFLMPAGVTQNNSafanlkdfqdwfskpmdrLIEEGQDMNPEamNTVAKLHRVLRPY 675
Cdd:cd18061    159 LEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSEST------------------FMQEFGDLKTE--EQVQKLQAILKPM 218


                   ....
gi 1246742950  676 LLRR 679
Cdd:cd18061    219 MLRR 222
DEXHc_HLTF1_SMARC3 cd18071
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ...
 468-679 1.92e-28

DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350829 [Multi-domain]  Cd Length: 239  Bit Score: 115.26  E-value: 1.92e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  468 GILADEMGLGKTIQTIALLAHlacekenwGPHLIIVPTSVMLNWEMEFKKFL-PG-FKILTYYGNPQERKEKRSGWYKpd 545
Cdd:cd18071     51 GILADDMGLGKTLTTISLILA--------NFTLIVCPLSVLSNWETQFEEHVkPGqLKVYTYHGGERNRDPKLLSKYD-- 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  546 twhVCITSYQLVLQDH-----QPFRRKKWQYMILDEAHNIKNFRSQRWQSLLNFNAEHRLLLTGTPLQNNLVELWSLLYF 620
Cdd:cd18071    121 ---IVLTTYNTLASDFgakgdSPLHTINWLRVVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQNSPKDLGSLLSF 197

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1246742950  621 LmpagvtqnnsafaNLKDFQD--WFSKPMDRLIEEGQDMNpeamntVAKLHRVLRPYLLRR 679
Cdd:cd18071    198 L-------------HLKPFSNpeYWRRLIQRPLTMGDPTG------LKRLQVLMKQITLRR 239
DEXHc_TTF2 cd18072
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ...
 447-679 3.40e-28

DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350830 [Multi-domain]  Cd Length: 241  Bit Score: 114.50  E-value: 3.40e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  447 LREYQQYGLEWLTALHDSN-TNGILADEMGLGKTIQTIALLahLACEK-------------ENWGPH-----------LI 501
Cdd:cd18072      1 LLLHQKQALAWLLWRERQKpRGGILADDMGLGKTLTMIALI--LAQKNtqnrkeeekekalTEWESKkdstlvpsagtLV 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  502 IVPTSVMLNWEMEFKKFLPG--FKILTYYGNPQERKEKRSGWYKpdtwhVCITSYQLVLQDH---------QPFRRKKWQ 570
Cdd:cd18072     79 VCPASLVHQWKNEVESRVASnkLRVCLYHGPNRERIGEVLRDYD-----IVITTYSLVAKEIptykeesrsSPLFRIAWA 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  571 YMILDEAHNIKNFRSQRWQSLLNFNAEHRLLLTGTPLQNNLVELWSLLYFLmpagvtqNNSAFANLKDFQDWfskpmdrl 650
Cdd:cd18072    154 RIILDEAHNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKFL-------RCSPFDDLKVWKKQ-------- 218

                          250       260
                   ....*....|....*....|....*....
gi 1246742950  651 ieegqdMNPEAMNTVAKLHRVLRPYLLRR 679
Cdd:cd18072    219 ------VDNKSRKGGERLNILTKSLLLRR 241
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 991-1104 4.49e-28

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 109.61  E-value: 4.49e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  991 GKLQVLDRLLKDlvSNGHRVLIFTQMTKVLDIlEQFLNIHGHRYLRLDGATKIEQRQILTERFNNDDKIpvFILSTRSGG 1070
Cdd:pfam00271    1 EKLEALLELLKK--ERGGKVLIFSQTKKTLEA-ELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKID--VLVATDVAE 75

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1246742950 1071 LGINLTGADTVIFYDSDWNPQLDAQAQDRSHRIG 1104
Cdd:pfam00271   76 RGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
DEXHc_RAD54B cd18066
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ...
 447-679 4.48e-24

DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350824 [Multi-domain]  Cd Length: 235  Bit Score: 102.23  E-value: 4.48e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  447 LREYQQYGLEWLTAL-----HDSNTNGILADEMGLGKTIQTIALLAHLACEkenwGPH---------LIIVPTSVMLNWE 512
Cdd:cd18066      1 LRPHQREGIEFLYECvmgmrVNERFGAILADEMGLGKTLQCISLIWTLLRQ----GPYggkpvikraLIVTPGSLVKNWK 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  513 MEFKKFLPGFKILTYYGNPQERKEKrsgWYKPDTWHVCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKNFRSQRWQSLL 592
Cdd:cd18066     77 KEFQKWLGSERIKVFTVDQDHKVEE---FIASPLYSVLIISYEMLLRSLDQISKLNFDLVICDEGHRLKNTSIKTTTALT 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  593 NFNAEHRLLLTGTPLQNNLVELWSLLYFLMPAgvtqnnsAFANLKDFQDWFSKPMDRLIEEgqDMNPEAMN----TVAKL 668
Cdd:cd18066    154 SLSCERRIILTGTPIQNDLQEFFALIDFVNPG-------ILGSLSTYRKVYEEPIVRSREP--TATPEEKKlgeaRAAEL 224

                          250
                   ....*....|.
gi 1246742950  669 HRVLRPYLLRR 679
Cdd:cd18066    225 TRLTGLFILRR 235
HELICc smart00490
helicase superfamily c-terminal domain;
1021-1104 5.18e-23

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 94.20  E-value: 5.18e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  1021 DILEQFLNIHGHRYLRLDGATKIEQRQILTERFNNDDKipVFILSTRSGGLGINLTGADTVIFYDSDWNPQLDAQAQDRS 1100
Cdd:smart00490    1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKI--KVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRA 78


                    ....
gi 1246742950  1101 HRIG 1104
Cdd:smart00490   79 GRAG 82
DEXHc_ATRX cd18068
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ...
 468-649 3.76e-22

DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350826 [Multi-domain]  Cd Length: 246  Bit Score: 97.27  E-value: 3.76e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  468 GILADEMGLGKTIQTIALLaH--LACEK-ENWGPHLIIVPTSVMLNWEMEFKKFLPGFKI--------LTYYGNPQERKE 536
Cdd:cd18068     31 CILAHCMGLGKTLQVVTFL-HtvLLCEKlENFSRVLVVCPLNTVLNWLNEFEKWQEGLKDeekievneLATYKRPQERSY 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  537 KRSGWYKpdTWHVCITSYQL---VLQDHQPFRRKKWQ-------------YMILDEAHNIKNFRSQRWQSLLNFNAEHRL 600
Cdd:cd18068    110 KLQRWQE--EGGVMIIGYDMyriLAQERNVKSREKLKeifnkalvdpgpdFVVCDEGHILKNEASAVSKAMNSIRTKRRI 187

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 1246742950  601 LLTGTPLQNNLVELWSLLYFLMPagvtqnnSAFANLKDFQDWFSKPMDR 649
Cdd:cd18068    188 VLTGTPLQNNLIEYHCMVNFVKP-------NLLGTIKEFRNRFVNPIQN 229
DEXHc_RAD54A cd18067
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ...
 447-623 4.22e-22

DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350825 [Multi-domain]  Cd Length: 243  Bit Score: 96.77  E-value: 4.22e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  447 LREYQQYGLEWL----TALHDSNTNG-ILADEMGLGKTIQTIALLAHLACEKENWGPHL----IIVPTSVMLNWEMEFKK 517
Cdd:cd18067      1 LRPHQREGVKFLyrcvTGRRIRGSHGcIMADEMGLGKTLQCITLMWTLLRQSPQCKPEIdkaiVVSPSSLVKNWANELGK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  518 FL-PGFKILTYYGNPQERKEKRS-GWYKPD----TWHVCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKNFRSQRWQSL 591
Cdd:cd18067     81 WLgGRLQPLAIDGGSKKEIDRKLvQWASQQgrrvSTPVLIISYETFRLHVEVLQKGEVGLVICDEGHRLKNSDNQTYQAL 160

                          170       180       190
                   ....*....|....*....|....*....|..
gi 1246742950  592 LNFNAEHRLLLTGTPLQNNLVELWSLLYFLMP 623
Cdd:cd18067    161 DSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNP 192
DEXDc_RapA cd18011
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ...
 458-623 3.05e-21

DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350769 [Multi-domain]  Cd Length: 207  Bit Score: 93.12  E-value: 3.05e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  458 LTALHDSNTNGILADEMGLGKTIQTIALLAHLACEkenwGPH---LIIVPTSVMLNWEMEFK-KFLPGFKILTYYGNPQE 533
Cdd:cd18011     10 LRALRKPPVRLLLADEVGLGKTIEAGLIIKELLLR----GDAkrvLILCPASLVEQWQDELQdKFGLPFLILDRETAAQL 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  534 RKEKRSGWykpDTWHVCITSYQLVLQD---HQPFRRKKWQYMILDEAHNIKN----FRSQRWQ--SLLNFNAEHRLLLTG 604
Cdd:cd18011     86 RRLIGNPF---EEFPIVIVSLDLLKRSeerRGLLLSEEWDLVVVDEAHKLRNsgggKETKRYKlgRLLAKRARHVLLLTA 162

                          170
                   ....*....|....*....
gi 1246742950  605 TPLQNNLVELWSLLYFLMP 623
Cdd:cd18011    163 TPHNGKEEDFRALLSLLDP 181
DEXHc_ARIP4 cd18069
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ...
 469-658 5.50e-21

DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350827 [Multi-domain]  Cd Length: 227  Bit Score: 93.34  E-value: 5.50e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  469 ILADEMGLGKTIQTIA----LLAHLACEKEnwgphLIIVPTSVMLNWEMEFKKFLPGFKILtyyGNPQER---------- 534
Cdd:cd18069     32 ILAHSMGLGKTLQVISfldvLLRHTGAKTV-----LAIVPVNTLQNWLSEFNKWLPPPEAL---PNVRPRpfkvfilnde 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  535 -KEKRSGWYKPDTWhvcITSYQLVLQDHQPFR-RKKWQYMILDEAHNIKNFRSQRWQSLLNFNAEHRLLLTGTPLQNNLV 612
Cdd:cd18069    104 hKTTAARAKVIEDW---VKDGGVLLMGYEMFRlRPGPDVVICDEGHRIKNCHASTSQALKNIRSRRRIVLTGYPLQNNLI 180

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 1246742950  613 ELWSLLYFLMPagvtqnnSAFANLKDFQDWFSKPmdrlIEEGQDMN 658
Cdd:cd18069    181 EYWCMVDFVRP-------DFLGTRQEFSNMFERP----ILNGQCVD 215
DEXQc_SHPRH cd18070
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ...
 447-623 7.28e-16

DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350828 [Multi-domain]  Cd Length: 257  Bit Score: 78.92  E-value: 7.28e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  447 LREYQQYGLEWLTALhdsntNGILADEMGLGKTIQTIALLAH------------LACEKENWGPH-------------LI 501
Cdd:cd18070      1 LLPYQRRAVNWMLVP-----GGILADEMGLGKTVEVLALILLhprpdndldaadDDSDEMVCCPDclvaetpvsskatLI 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  502 IVPTSVMLNWEMEFKKFLP-GFKILTYYGNpqerkEKRSGWYKPDTWHVC-----ITSYQlVLQD-------------HQ 562
Cdd:cd18070     76 VCPSAILAQWLDEINRHVPsSLKVLTYQGV-----KKDGALASPAPEILAeydivVTTYD-VLRTelhyaeanrsnrrRR 149

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1246742950  563 PFRRK----------KWQYMILDEAHNIKNFRSQRWQSLLNFNAEHRLLLTGTPLQNNLVELWSLLYFLMP 623
Cdd:cd18070    150 RQKRYeappsplvlvEWWRVCLDEAQMVESSTSKAAEMARRLPRVNRWCVSGTPIQRGLDDLFGLLSFLGV 220
DEXQc_bact_SNF2 cd18013
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ...
 447-621 1.23e-15

DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350771 [Multi-domain]  Cd Length: 218  Bit Score: 77.39  E-value: 1.23e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  447 LREYQQYGLEWLTalhDSNTNGILADeMGLGKTIQTIALLAHLAcEKENWGPHLIIVPTSVMLN-WEMEFKKFlPGFKIL 525
Cdd:cd18013      1 PHPYQKVAINFII---EHPYCGLFLD-MGLGKTVTTLTALSDLQ-LDDFTRRVLVIAPLRVARStWPDEVEKW-NHLRNL 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  526 TYY---GNPQERKEKRSGwykpdTWHVCITSYQ----LVLQDHQPFrrkKWQYMILDEAHNIKNFRSQRWQSL--LNFNA 596
Cdd:cd18013     75 TVSvavGTERQRSKAANT-----PADLYVINREnlkwLVNKSGDPW---PFDMVVIDELSSFKSPRSKRFKALrkVRPVI 146

                          170       180
                   ....*....|....*....|....*
gi 1246742950  597 EHRLLLTGTPLQNNLVELWSLLYFL 621
Cdd:cd18013    147 KRLIGLTGTPSPNGLMDLWAQIALL 171
DEXHc_RE cd17926
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ...
 447-606 9.23e-15

DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350684 [Multi-domain]  Cd Length: 146  Bit Score: 72.72  E-value: 9.23e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  447 LREYQQYGLE-WLtaLHDSNTNGILADEMGLGKTIQTIALLAHLACEKEnwgphLIIVPTSVMLN-WEMEFKKFLPGFKI 524
Cdd:cd17926      1 LRPYQEEALEaWL--AHKNNRRGILVLPTGSGKTLTALALIAYLKELRT-----LIVVPTDALLDqWKERFEDFLGDSSI 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  525 LTYYGNPQERKEKRSgwykpdtwhVCITSYQLVLQDHQPFRR--KKWQYMILDEAHNI--KNFRsqrwQSLLNFNAEHRL 600
Cdd:cd17926     74 GLIGGGKKKDFDDAN---------VVVATYQSLSNLAEEEKDlfDQFGLLIVDEAHHLpaKTFS----EILKELNAKYRL 140


                   ....*.
gi 1246742950  601 LLTGTP 606
Cdd:cd17926    141 GLTATP 146
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
443-606 2.22e-14

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 77.76  E-value: 2.22e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  443 FRGTLREYQQYGLE-WLTALHDSNTNGILADEMGLGKTIqtiaLLAHLACEKENWGPHLIIVPTSVMLN-WEMEFKKFLP 520
Cdd:COG1061     77 TSFELRPYQQEALEaLLAALERGGGRGLVVAPTGTGKTV----LALALAAELLRGKRVLVLVPRRELLEqWAEELRRFLG 152

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  521 GFKIltyygnpqerkekrSGWYKPDTWHVCITSYQ-LVLQDHQPFRRKKWQYMILDEAHNIknfRSQRWQSLLN-FNAEH 598
Cdd:COG1061    153 DPLA--------------GGGKKDSDAPITVATYQsLARRAHLDELGDRFGLVIIDEAHHA---GAPSYRRILEaFPAAY 215


                   ....*...
gi 1246742950  599 RLLLTGTP 606
Cdd:COG1061    216 RLGLTATP 223
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
 467-605 4.10e-09

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 56.64  E-value: 4.10e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  467 NGILADEMGLGKTIQTIALLAHLACEKEnwGPHLIIVPT-SVMLNWEMEFKKFL-PGFKILTYYG--NPQERKEKRSgwy 542
Cdd:cd00046      3 NVLITAPTGSGKTLAALLAALLLLLKKG--KKVLVLVPTkALALQTAERLRELFgPGIRVAVLVGgsSAEEREKNKL--- 77

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1246742950  543 kpDTWHVCITSYQLV---LQDHQPFRRKKWQYMILDEAHNI-KNFRSQRWQSLLNFNAE----HRLLLTGT 605
Cdd:cd00046     78 --GDADIIIATPDMLlnlLLREDRLFLKDLKLIIVDEAHALlIDSRGALILDLAVRKAGlknaQVILLSAT 146
SF2_C_DEAD cd18787
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ...
 988-1106 1.09e-04

C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350174 [Multi-domain]  Cd Length: 131  Bit Score: 43.26  E-value: 1.09e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  988 YDCGKLQVLDRLLKDLVSNGH--RVLIFTQMTKVLDILEQFLNIHGHRYLRLDGATKIEQRQILTERFNNdDKIPVFI-- 1063
Cdd:cd18787      6 VVVEEEEKKLLLLLLLLEKLKpgKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRS-GKVRVLVat 84

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1246742950 1064 -LSTRsgglGINLTGADTVIFYDsdwnpqLDAQAQDRSHRIGQT 1106
Cdd:cd18787     85 dVAAR----GLDIPGVDHVINYD------LPRDAEDYVHRIGRT 118
DEXHc_RE_I_III_res cd18032
DEXH-box helicase domain of type III restriction enzyme res subunit; Members of this model ...
 447-606 1.12e-04

DEXH-box helicase domain of type III restriction enzyme res subunit; Members of this model includes both type I and type III restriction enzymes. Both are hetero-oligomeric proteins. Type I REs are encoded by three closely linked genes: a specificity subunit (HsdS or S) for recognizing a DNA sequence, a methylation subunit (HsdM or M) for methylating the recognized target bases, and a restriction subunit (HsdR or R) for the translocation and random cleavage of non-methylated DNA. They show diverse catalytic activities, including methyltransferase (MTase), ATP hydrolase (ATPase), DNA translocation and restriction activities. These enzymes cut at a site that differs, and is a random distance (at least 1000 bp) away, from their recognition site. Cleavage at these random sites follows a process of DNA translocation, which shows that these enzymes are also molecular motors. The recognition site is asymmetrical and is composed of two specific portions: one containing 3-4 nucleotides, and another containing 4-5 nucleotides, separated by a non-specific spacer of about 6-8 nucleotides. Type III enzymes are composed of two subunits, Res and Mod. The Mod subunit recognizes the DNA sequence specific for the system and is a modification methyltransferase; as such, it is functionally equivalent to the M and S subunits of type I restriction endonucleases. Res is required for restriction, although it has no enzymatic activity on its own. Type III enzymes recognize short 5-6 bp-long asymmetric DNA sequences and cleave 25-27 bp downstream to leave short, single-stranded 5' protrusions. They require the presence of two inversely oriented unmethylated recognition sites for restriction to occur. These enzymes methylate only one strand of the DNA, at the N-6 position of adenosyl residues, so newly replicated DNA will have only one strand methylated, which is sufficient to protect against restriction. Both type I and type III REs are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350790 [Multi-domain]  Cd Length: 163  Bit Score: 44.09  E-value: 1.12e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  447 LREYQQyglEWLTALHDSNTNG------ILAdeMGLGKTIQTIALLAHLAceKENWGPH-LIIVPTSVMLNWEM-EFKKF 518
Cdd:cd18032      1 PRYYQQ---EAIEALEEAREKGqrrallVMA--TGTGKTYTAAFLIKRLL--EANRKKRiLFLAHREELLEQAErSFKEV 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  519 LPGFKILTYYGNPQERKEKRsgwykpdtwhVCITSYQLVLQ--DHQPFRRKKWQYMILDEAHniknfRS--QRWQSLLN- 593
Cdd:cd18032     74 LPDGSFGNLKGGKKKPDDAR----------VVFATVQTLNKrkRLEKFPPDYFDLIIIDEAH-----HAiaSSYRKILEy 138

                          170
                   ....*....|...
gi 1246742950  594 FNAEHRLLLTGTP 606
Cdd:cd18032    139 FEPAFLLGLTATP 151
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
 1062-1106 4.88e-04

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 39.99  E-value: 4.88e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1246742950 1062 FILSTRSGGLGINLTGADTVIFYDSDWNPQLDAQAQDRSHRIGQT 1106
Cdd:cd18785     25 ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKD 69
PTZ00110 PTZ00110
helicase; Provisional
 996-1106 5.43e-04

helicase; Provisional


Pssm-ID: 240273 [Multi-domain]  Cd Length: 545  Bit Score: 44.38  E-value: 5.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  996 LDRLLKDLVSNGHRVLIFTQMTKVLDILEQFLNIHGHRYLRLDGATKIEQRQILTERFNNdDKIPVFIlSTRSGGLGINL 1075
Cdd:PTZ00110   366 LKMLLQRIMRDGDKILIFVETKKGADFLTKELRLDGWPALCIHGDKKQEERTWVLNEFKT-GKSPIMI-ATDVASRGLDV 443

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1246742950 1076 TGADTVIFYDsdwnpqLDAQAQDRSHRIGQT 1106
Cdd:PTZ00110   444 KDVKYVINFD------FPNQIEDYVHRIGRT 468
HSA pfam07529
HSA domain; This domain is predicted to bind DNA and is often found associated with helicases. ...
 116-178 5.67e-04

HSA domain; This domain is predicted to bind DNA and is often found associated with helicases. This region does not form a compact domain in the known structures.


Pssm-ID: 462194 [Multi-domain]  Cd Length: 67  Bit Score: 39.48  E-value: 5.67e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1246742950  116 SYRDNLLSHVNGYARSMHNDRKVRASRSRRISGMILAHFKrlsgadeKKAKEEDKRIRLLAKR 178
Cdd:pfam07529   10 THHDYLLEEILWHSKDFKQERRWKRARAKKLARAVAQYHK-------NIEKEEQKRIEREEKQ 65
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 475-606 1.21e-03

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 41.07  E-value: 1.21e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742950  475 GLGKT-IQTIALLAHLACEKEnwGPH-LIIVPTSVmLNWEM--EFKKFL--PGFKILTYYGNpQERKEKRSGWYKPdtwH 548
Cdd:pfam00270   24 GSGKTlAFLLPALEALDKLDN--GPQaLVLAPTRE-LAEQIyeELKKLGkgLGLKVASLLGG-DSRKEQLEKLKGP---D 96

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1246742950  549 VCITSYQlVLQDHQPFRR--KKWQYMILDEAHNI--KNFRSQrWQSLLN-FNAEHR-LLLTGTP 606
Cdd:pfam00270   97 ILVGTPG-RLLDLLQERKllKNLKLLVLDEAHRLldMGFGPD-LEEILRrLPKKRQiLLLSATL 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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