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Conserved domains on  [gi|1243938379|ref|NP_001342490|]
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diphthine methyltransferase isoform e [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1903264)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl43672
WD40 repeat [General function prediction only];
7-94 1.53e-07

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.84  E-value: 1.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938379   7 TGGDDCLLRGWDTRmLGTPVFTSKRHCMGVCSIQSSPhQEHILATGSYDEHVLLWDTRNIRQPLADVPVQGGVWRLKWHP 86
Cdd:COG2319   305 SGSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP 382


                  ....*...
gi 1243938379  87 VHHHLLLA 94
Cdd:COG2319   383 DGRTLASG 390
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
7-94 1.53e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.84  E-value: 1.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938379   7 TGGDDCLLRGWDTRmLGTPVFTSKRHCMGVCSIQSSPhQEHILATGSYDEHVLLWDTRNIRQPLADVPVQGGVWRLKWHP 86
Cdd:COG2319   305 SGSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP 382


                  ....*...
gi 1243938379  87 VHHHLLLA 94
Cdd:COG2319   383 DGRTLASG 390
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 25-136 4.50e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.78  E-value: 4.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938379  25 PVFTSKRHCMGVCSIQSSPHQEHiLATGSYDEHVLLWDTRNIRQPLADVPVQGGVWRLKWHPvHHHLLLAACMHNGFKIL 104
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLW 78

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1243938379 105 NcqkaIEEKQDITVLTSHEmpnSLVYGADWSW 136
Cdd:cd00200    79 D----LETGECVRTLTGHT---SYVSSVAFSP 103
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 23-62 1.79e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 1.79e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1243938379   23 GTPVFTSKRHCMGVCSIQSSPHqEHILATGSYDEHVLLWD 62
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
7-94 1.53e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.84  E-value: 1.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938379   7 TGGDDCLLRGWDTRmLGTPVFTSKRHCMGVCSIQSSPhQEHILATGSYDEHVLLWDTRNIRQPLADVPVQGGVWRLKWHP 86
Cdd:COG2319   305 SGSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP 382


                  ....*...
gi 1243938379  87 VHHHLLLA 94
Cdd:COG2319   383 DGRTLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
7-137 2.05e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.29  E-value: 2.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938379   7 TGGDDCLLRGWDTRmLGTPVFTSKRHCMGVCSIQSSPHQEHiLATGSYDEHVLLWDTRNIRQPLADVPVQGGVWRLKWHP 86
Cdd:COG2319   263 SGSADGTVRLWDLA-TGELLRTLTGHSGGVNSVAFSPDGKL-LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP 340

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1243938379  87 vHHHLLLAACMHNGFKILNcqkaIEEKQDITVLTSHEMP-NSLVYGADWSWL 137
Cdd:COG2319   341 -DGKTLASGSDDGTVRLWD----LATGELLRTLTGHTGAvTSVAFSPDGRTL 387
WD40 COG2319
WD40 repeat [General function prediction only];
7-135 2.29e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.29  E-value: 2.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938379   7 TGGDDCLLRGWDTRmLGTPVFTSKRHCMGVCSIQSSPhQEHILATGSYDEHVLLWDTRNIRQPLADVPVQGGVWRLKWHP 86
Cdd:COG2319   137 SGSADGTVRLWDLA-TGKLLRTLTGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP 214

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1243938379  87 vHHHLLLAACMHNGFKILNcqkaIEEKQDITVLTSHEmpnSLVYGADWS 135
Cdd:COG2319   215 -DGKLLASGSADGTVRLWD----LATGKLLRTLTGHS---GSVRSVAFS 255
WD40 COG2319
WD40 repeat [General function prediction only];
7-135 2.42e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.82  E-value: 2.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938379   7 TGGDDCLLRGWDTRmLGTPVFTSKRHCMGVCSIQSSPHQeHILATGSYDEHVLLWDTRNiRQPLADVPVQGG-VWRLKWH 85
Cdd:COG2319   179 SGSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDG-KLLASGSADGTVRLWDLAT-GKLLRTLTGHSGsVRSVAFS 255

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1243938379  86 PvHHHLLLAACMHNGFKILNcqkaIEEKQDITVLTSHempNSLVYGADWS 135
Cdd:COG2319   256 P-DGRLLASGSADGTVRLWD----LATGELLRTLTGH---SGGVNSVAFS 297
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 25-136 4.50e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.78  E-value: 4.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938379  25 PVFTSKRHCMGVCSIQSSPHQEHiLATGSYDEHVLLWDTRNIRQPLADVPVQGGVWRLKWHPvHHHLLLAACMHNGFKIL 104
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLW 78

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1243938379 105 NcqkaIEEKQDITVLTSHEmpnSLVYGADWSW 136
Cdd:cd00200    79 D----LETGECVRTLTGHT---SYVSSVAFSP 103
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-135 9.11e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.01  E-value: 9.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938379   7 TGGDDCLLRGWDTRMlGTPVFTSKRHCMGVCSIQSSPHQeHILATGSYDEHVLLWDTRNiRQPLADVP-VQGGVWRLKWH 85
Cdd:cd00200    68 SGSSDKTIRLWDLET-GECVRTLTGHTSYVSSVAFSPDG-RILSSSSRDKTIKVWDVET-GKCLTTLRgHTDWVNSVAFS 144

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1243938379  86 PVHHhlLLAACMHNGF-KILNcqkaIEEKQDITVLTSHEMPnslVYGADWS 135
Cdd:cd00200   145 PDGT--FVASSSQDGTiKLWD----LRTGKCVATLTGHTGE---VNSVAFS 186
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 23-62 1.79e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 1.79e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1243938379   23 GTPVFTSKRHCMGVCSIQSSPHqEHILATGSYDEHVLLWD 62
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-138 2.58e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 38.47  E-value: 2.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938379   7 TGGDDCLLRGWDTRMlGTPVFTSKRHCMGVCSIQSSPHQeHILATGSYDEHVLLWDTRNIRqpladvPVQ------GGVW 80
Cdd:cd00200   110 SSSRDKTIKVWDVET-GKCLTTLRGHTDWVNSVAFSPDG-TFVASSSQDGTIKLWDLRTGK------CVAtltghtGEVN 181

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1243938379  81 RLKWHPVHHHLLLAACmHNGFKILNCQKAIEekqdITVLTSHEMP-NSLVYGADWSWLF 138
Cdd:cd00200   182 SVAFSPDGEKLLSSSS-DGTIKLWDLSTGKC----LGTLRGHENGvNSVAFSPDGYLLA 235
WD40 COG2319
WD40 repeat [General function prediction only];
7-65 5.61e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 37.97  E-value: 5.61e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1243938379   7 TGGDDCLLRGWDTRmLGTPVFTSKRHCMGVCSIQSSPHqEHILATGSYDEHVLLWDTRN 65
Cdd:COG2319   347 SGSDDGTVRLWDLA-TGELLRTLTGHTGAVTSVAFSPD-GRTLASGSADGTVRLWDLAT 403
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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