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Conserved domains on  [gi|1243938511|ref|NP_001342489|]
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diphthine methyltransferase isoform d [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1903264)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl43672
WD40 repeat [General function prediction only];
16-104 1.12e-07

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.22  E-value: 1.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938511  16 LSGGDDCLLRGWDTRmLGTPVFTSKRHCMGVCSIQSSPhQEHILATGSYDEHVLLWDTRNIRQPLADVPVQGGVWRLKWH 95
Cdd:COG2319   304 ASGSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFS 381


                  ....*....
gi 1243938511  96 PVHHHLLLA 104
Cdd:COG2319   382 PDGRTLASG 390
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
16-104 1.12e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.22  E-value: 1.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938511  16 LSGGDDCLLRGWDTRmLGTPVFTSKRHCMGVCSIQSSPhQEHILATGSYDEHVLLWDTRNIRQPLADVPVQGGVWRLKWH 95
Cdd:COG2319   304 ASGSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFS 381


                  ....*....
gi 1243938511  96 PVHHHLLLA 104
Cdd:COG2319   382 PDGRTLASG 390
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 16-145 2.98e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.55  E-value: 2.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938511  16 LSGGDDCLLRGWDTRMlGTPVFTSKRHCMGVCSIQSSPHQeHILATGSYDEHVLLWDTRNiRQPLADVP-VQGGVWRLKW 94
Cdd:cd00200    67 ASGSSDKTIRLWDLET-GECVRTLTGHTSYVSSVAFSPDG-RILSSSSRDKTIKVWDVET-GKCLTTLRgHTDWVNSVAF 143

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1243938511  95 HPVHHhlLLAACMHNGF-KILNcqkaIEEKQDITVLTSHEMPnslVYGADWS 145
Cdd:cd00200   144 SPDGT--FVASSSQDGTiKLWD----LRTGKCVATLTGHTGE---VNSVAFS 186
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 33-72 1.93e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 1.93e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1243938511   33 GTPVFTSKRHCMGVCSIQSSPHqEHILATGSYDEHVLLWD 72
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
16-104 1.12e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.22  E-value: 1.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938511  16 LSGGDDCLLRGWDTRmLGTPVFTSKRHCMGVCSIQSSPhQEHILATGSYDEHVLLWDTRNIRQPLADVPVQGGVWRLKWH 95
Cdd:COG2319   304 ASGSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFS 381


                  ....*....
gi 1243938511  96 PVHHHLLLA 104
Cdd:COG2319   382 PDGRTLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
16-145 1.48e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.67  E-value: 1.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938511  16 LSGGDDCLLRGWDTRmLGTPVFTSKRHCMGVCSIQSSPhQEHILATGSYDEHVLLWDTRNIRQPLADVPVQGGVWRLKWH 95
Cdd:COG2319   136 ASGSADGTVRLWDLA-TGKLLRTLTGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS 213

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1243938511  96 PvHHHLLLAACMHNGFKILNcqkaIEEKQDITVLTSHEmpnSLVYGADWS 145
Cdd:COG2319   214 P-DGKLLASGSADGTVRLWD----LATGKLLRTLTGHS---GSVRSVAFS 255
WD40 COG2319
WD40 repeat [General function prediction only];
16-147 1.57e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.67  E-value: 1.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938511  16 LSGGDDCLLRGWDTRmLGTPVFTSKRHCMGVCSIQSSPHQEHiLATGSYDEHVLLWDTRNIRQPLADVPVQGGVWRLKWH 95
Cdd:COG2319   262 ASGSADGTVRLWDLA-TGELLRTLTGHSGGVNSVAFSPDGKL-LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS 339

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1243938511  96 PvHHHLLLAACMHNGFKILNcqkaIEEKQDITVLTSHEMP-NSLVYGADWSWL 147
Cdd:COG2319   340 P-DGKTLASGSDDGTVRLWD----LATGELLRTLTGHTGAvTSVAFSPDGRTL 387
WD40 COG2319
WD40 repeat [General function prediction only];
17-145 2.28e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.21  E-value: 2.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938511  17 SGGDDCLLRGWDTRmLGTPVFTSKRHCMGVCSIQSSPHQeHILATGSYDEHVLLWDTRNiRQPLADVPVQGG-VWRLKWH 95
Cdd:COG2319   179 SGSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDG-KLLASGSADGTVRLWDLAT-GKLLRTLTGHSGsVRSVAFS 255

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1243938511  96 PvHHHLLLAACMHNGFKILNcqkaIEEKQDITVLTSHempNSLVYGADWS 145
Cdd:COG2319   256 P-DGRLLASGSADGTVRLWD----LATGELLRTLTGH---SGGVNSVAFS 297
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 16-145 2.98e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.55  E-value: 2.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938511  16 LSGGDDCLLRGWDTRMlGTPVFTSKRHCMGVCSIQSSPHQeHILATGSYDEHVLLWDTRNiRQPLADVP-VQGGVWRLKW 94
Cdd:cd00200    67 ASGSSDKTIRLWDLET-GECVRTLTGHTSYVSSVAFSPDG-RILSSSSRDKTIKVWDVET-GKCLTTLRgHTDWVNSVAF 143

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1243938511  95 HPVHHhlLLAACMHNGF-KILNcqkaIEEKQDITVLTSHEMPnslVYGADWS 145
Cdd:cd00200   144 SPDGT--FVASSSQDGTiKLWD----LRTGKCVATLTGHTGE---VNSVAFS 186
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 35-146 4.90e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.78  E-value: 4.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938511  35 PVFTSKRHCMGVCSIQSSPHQEHiLATGSYDEHVLLWDTRNIRQPLADVPVQGGVWRLKWHPvHHHLLLAACMHNGFKIL 114
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLW 78

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1243938511 115 NcqkaIEEKQDITVLTSHEmpnSLVYGADWSW 146
Cdd:cd00200    79 D----LETGECVRTLTGHT---SYVSSVAFSP 103
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 16-148 1.59e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 39.24  E-value: 1.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938511  16 LSGGDDCLLRGWDTRMlGTPVFTSKRHCMGVCSIQSSPHQeHILATGSYDEHVLLWDTRNIRqpladvPVQ------GGV 89
Cdd:cd00200   109 SSSSRDKTIKVWDVET-GKCLTTLRGHTDWVNSVAFSPDG-TFVASSSQDGTIKLWDLRTGK------CVAtltghtGEV 180

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938511  90 WRLKWHPVHHHLLLAACmHNGFKILNCQKAIEekqdITVLTSHEMP-NSLVYGADWSWLF 148
Cdd:cd00200   181 NSVAFSPDGEKLLSSSS-DGTIKLWDLSTGKC----LGTLRGHENGvNSVAFSPDGYLLA 235
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 33-72 1.93e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 1.93e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1243938511   33 GTPVFTSKRHCMGVCSIQSSPHqEHILATGSYDEHVLLWD 72
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
16-75 3.78e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 38.35  E-value: 3.78e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243938511  16 LSGGDDCLLRGWDTRmLGTPVFTSKRHCMGVCSIQSSPHqEHILATGSYDEHVLLWDTRN 75
Cdd:COG2319   346 ASGSDDGTVRLWDLA-TGELLRTLTGHTGAVTSVAFSPD-GRTLASGSADGTVRLWDLAT 403
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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