|
Name |
Accession |
Description |
Interval |
E-value |
| Arm_APC_u3 |
pfam16629 |
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ... |
641-928 |
1.19e-166 |
|
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
:
Pssm-ID: 435476 Cd Length: 293 Bit Score: 515.29 E-value: 1.19e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 641 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRSKQRHKQSLYGDYVFDTNRHDDN-- 718
Cdd:pfam16629 1 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNVYSEYVLDSGRHDDSvc 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 719 RSDNFNTGNMTVLSPYLNTTVLPSSSSSRG--SLDSSRSEKDRSLERERGIGLGNYHPATENPGTSSKR-GLQISTTAAQ 795
Cdd:pfam16629 81 RSDNFNTGNVTVLSPYLNTTVLPSSSSRDSrgNAESSRSEKDRSLDRERGAGLSNFHPATENSGNSSKRiGMQISTTAAQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 796 IAKVMEEVSAIHTSQEDRSSGSTTELHCVTDERNALRRSSAAHTHSNTYNFTKSENSNRTCSMPYAKLEYKRSSNDSLNS 875
Cdd:pfam16629 161 IAKVMEEVSSMHISQEDRSSGSTSDMHCMQDDRNSIRRSSTAHPHSNVYSFNKSESSNRPCPMPYMKMEYKRASNDSLNS 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1237937744 876 VSSSDGYGKRGQMKPSIESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDG 928
Cdd:pfam16629 241 VSSSDGYGKRGQMKPSVESYSEDDEGKFCSYGKYPADLAHKIHSANHMDDNDG 293
|
|
| APC_basic |
pfam05956 |
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ... |
2132-2477 |
3.68e-108 |
|
APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.
:
Pssm-ID: 428690 [Multi-domain] Cd Length: 336 Bit Score: 349.18 E-value: 3.68e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2132 SISRGRTMIHIPGVRNSSSSTSPVSKKGPPLKTPASKSPSEGQTATTS-PRGAKPSVKSELSPVARQTSQIGGSSKAPSR 2210
Cdd:pfam05956 1 VVFRGRTVIYMPGVKESQPSTSPPPKKTPPKTDAPAKNPNLGQQRSRSlHRLGKPSELADLSPPKRSATPPARISKAPSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2211 SGSRDSTPSRPAQQPLSRPIQSPGRNSISPGRNgisppnKLSQLPRTSSPSTASTKSSGSgKMSYTSPGRQMSQQNLTKQ 2290
Cdd:pfam05956 81 GSSRDSTPSRPPQKKLTSPSQSPGRLPGSGGRN------KLSPLPKTKSPARASTKKSGS-HKTQKSPVRIPFMQTPTKQ 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2291 TGLSKNASSI------PRSESASKGLNqmnngNGANKKVELSRMSSTKSSGSESDRSerpVLVRQSTFIKEAPSPTLRRK 2364
Cdd:pfam05956 154 TGLPRNPSPLvtnqpePRSESASKGLR-----SLPGKRLDLVRMSSARSSGSESDRS---GFLRQLTFIKESPSLLLRRR 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2365 LEESASfESLSPSSRPASPTRSQaqtpvlsPSLPDMSLSTHSSVQAGGWRKLPPNLSPTIEYNDGRPAKRHDIARSHSES 2444
Cdd:pfam05956 226 LELSAS-ESLSPSSQPASPRRSR-------PGLPAVFLCSSRCQELKGWRKQPPNPNSRAEPSDRPLTRRRPPRRTSSES 297
|
330 340 350
....*....|....*....|....*....|...
gi 1237937744 2445 PSRLPInRSGTWKREHSKHSSSLPRVSTWRRTG 2477
Cdd:pfam05956 298 PSRLPV-RNGTWKRETFKRYSSLPHINVWRRTG 329
|
|
| EB1_binding |
pfam05937 |
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the ... |
2579-2752 |
6.40e-89 |
|
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the microtubule-associating protein EB-1. At the C-terminus of the alignment is also a pfam00595 binding domain. A short motif in the middle of the region appears to be found in the APC2 proteins.
:
Pssm-ID: 399141 Cd Length: 174 Bit Score: 287.28 E-value: 6.40e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2579 RSGRSPTGNTPPVIDSVSEKANPNIKDSKDNQAKQNVGNGSVPMRTVGLENRLNSFIQVDAPDQKGTEIKPGQNNPVPVS 2658
Cdd:pfam05937 1 RSGRSPTGNTPPVIDSVPEKGIKDEKDSKDPQAKQNMGNGNVPVRTVGLENRLNSFIQSDSPDKKGTETKPLQNNPVPTP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2659 ETNESSIVERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVNNNTKKRDSKTDSTESSGTQ 2738
Cdd:pfam05937 81 ETNENPVSERTPFSSSSSSKHSSPSGAVAARVTPFNYNPSPRKSSADSSSARPSQIPTPVNNSTKKRDSKTESTDSSGNQ 160
|
170
....*....|....
gi 1237937744 2739 SPKRHSGSYLVTSV 2752
Cdd:pfam05937 161 SPKRHSGSYLVTSV 174
|
|
| APC_u5 |
pfam16630 |
Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of ... |
945-1044 |
1.90e-56 |
|
Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of natively unstructured sequence lying between the first and the second 15-residue beta-catenin binding motifs, APC_15aa, pfam05972, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
:
Pssm-ID: 406923 Cd Length: 100 Bit Score: 191.27 E-value: 1.90e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 945 LNSGRQSPSQNERWARPKHIIEDEIKQSEQRQSRNQSTTYPVYTESTDDKHLKFQPHFGQQECVSPYRSRGANGSETNRV 1024
Cdd:pfam16630 1 LNSGRQSPSQNERWARPKHIIEDEMKQSEQRQPRSQSTTYPVYTESGDDKHMKFQPRFGQQECVSPFRSRGSNGSEQSRV 80
|
90 100
....*....|....*....|
gi 1237937744 1025 GSNHGINQNVSQSLCQEDDY 1044
Cdd:pfam16630 81 GSSHGINQKVSQSLCQVDDY 100
|
|
| APC_u14 |
pfam16635 |
Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively ... |
1655-1748 |
9.81e-47 |
|
Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively unstructured sequence lying between the second SAMP pfam05924, and the fifth creatine-rich region, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
:
Pssm-ID: 435479 Cd Length: 94 Bit Score: 163.09 E-value: 9.81e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 1655 IMDQVQQASASSSAPNKNQLDGKKKKPTSPVKPIPQNTEYRTRVRKNADSKNNLNAERVFSDNKDSKKQNLKNNSKVFND 1734
Cdd:pfam16635 1 IMDQIQQASAASSGGSKSQQDGEKKKPTSPVKPMPQSSEYRARVRKNTESKNNLNSERSYPDNKESKKQNLKNNSRDFND 80
|
90
....*....|....
gi 1237937744 1735 KLPNNEDRVRGSFA 1748
Cdd:pfam16635 81 KLPNNEERTRGSFA 94
|
|
| APC_u9 |
pfam16633 |
Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of ... |
1192-1277 |
2.31e-35 |
|
Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of natively unstructured sequence lying between the first and second APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
:
Pssm-ID: 435478 Cd Length: 89 Bit Score: 130.38 E-value: 2.31e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 1192 AEDEI-GCNQTTQEADSANTLQIAEIKEKIGTRSAEDPVSEVPAVSQHPRTKSSRLQGSSLS-SESARHKAVEFSSGAKS 1269
Cdd:pfam16633 2 AEDEIeGRDQATRSTDNYNTLQITELKENSGAVSTEQTVSEVPSSSQHIRTKPNRLQASNLSpSDSSRHKAVEFSSGAKS 81
|
....*...
gi 1237937744 1270 PSKSGAQT 1277
Cdd:pfam16633 82 PSKSGAQT 89
|
|
| APC_u15 |
pfam16636 |
Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of ... |
1782-1856 |
3.89e-31 |
|
Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of natively unstructured sequence lying between the fifth and sixth creatine-rich, APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
:
Pssm-ID: 435480 Cd Length: 81 Bit Score: 118.04 E-value: 3.89e-31
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1237937744 1782 DLSREKAELRKAKENKESEAKVTSHTELTSNQQSANKTQAIAKQPINRGQPKPILQKQSTFPQSSKDIPDRGAAT 1856
Cdd:pfam16636 7 DLSREKAELRKGKETKETETKVTSHIEQPSNQQSTNRTQACQKHPPNRGQPKPLLQKQTTFPQSSKDIPDRGAAT 81
|
|
| APC_rep |
pfam18797 |
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ... |
317-375 |
7.60e-31 |
|
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.
:
Pssm-ID: 465870 Cd Length: 74 Bit Score: 117.26 E-value: 7.60e-31
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 1237937744 317 HLGTKIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAVCVLMKLSFDEEHRHAM 375
Cdd:pfam18797 16 HLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
|
|
| APC_u13 |
pfam16634 |
Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively ... |
1571-1624 |
1.75e-24 |
|
Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively unstructured sequence lying between the fourth creatine-rich region, APC_crr, pfam05923, and the SAMP pfam05924, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
:
Pssm-ID: 406927 Cd Length: 54 Bit Score: 98.33 E-value: 1.75e-24
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 1237937744 1571 IESPPNELAAGEGVRGGAQSGEFEKRDTIPTEGRSTDEAQGGKTSSVTIPELDD 1624
Cdd:pfam16634 1 IESPPNELANAESTGTGAESAEFEKRDTIPTEGRSTDDAQRGKKSNITTSALDD 54
|
|
| Suppressor_APC |
pfam11414 |
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ... |
137-217 |
1.77e-22 |
|
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.
:
Pssm-ID: 463275 Cd Length: 82 Bit Score: 93.47 E-value: 1.77e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 137 SRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTE-NFSLQTDMTRRQLEYEARQIRVAMEEQLG 215
Cdd:pfam11414 1 DYNMLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGtYFDYGSDAQQERLEFLLARIQEVNRCLGG 80
|
..
gi 1237937744 216 TC 217
Cdd:pfam11414 81 LI 82
|
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1546-1569 |
1.52e-07 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
:
Pssm-ID: 461781 Cd Length: 24 Bit Score: 49.30 E-value: 1.52e-07
|
| ARM |
smart00185 |
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ... |
558-598 |
4.46e-07 |
|
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.
:
Pssm-ID: 214547 [Multi-domain] Cd Length: 41 Bit Score: 48.19 E-value: 4.46e-07
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1237937744 558 NEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSA 598
Cdd:smart00185 1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
|
|
| SAMP |
pfam05924 |
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1942-1961 |
3.16e-05 |
|
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.
:
Pssm-ID: 461782 Cd Length: 22 Bit Score: 42.58 E-value: 3.16e-05
|
| ARM |
smart00185 |
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ... |
421-462 |
5.08e-04 |
|
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.
:
Pssm-ID: 214547 [Multi-domain] Cd Length: 41 Bit Score: 39.72 E-value: 5.08e-04
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 1237937744 421 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLSW 462
Cdd:smart00185 1 DDENKQAVVDA-GGLPALVELLKSEDEEVVKEAAWALSNLSS 41
|
|
| Arm |
pfam00514 |
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
600-640 |
6.78e-04 |
|
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.
:
Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 39.36 E-value: 6.78e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1237937744 600 NPKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMA 640
Cdd:pfam00514 1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
|
|
| SAMP |
pfam05924 |
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1625-1646 |
1.21e-03 |
|
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.
:
Pssm-ID: 461782 Cd Length: 22 Bit Score: 38.34 E-value: 1.21e-03
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1280-1302 |
3.60e-03 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
:
Pssm-ID: 461781 Cd Length: 24 Bit Score: 36.97 E-value: 3.60e-03
|
| PTZ00449 super family |
cl33186 |
104 kDa microneme/rhoptry antigen; Provisional |
1200-1610 |
4.62e-03 |
|
104 kDa microneme/rhoptry antigen; Provisional
The actual alignment was detected with superfamily member PTZ00449:
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 42.75 E-value: 4.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 1200 QTTQEAD---SANTLQIAEIKEKIGTRSAEDPvsEVPAVSQHPRTKSSRLQGSSLSSESARHKAVEFSSGAKSPSKSGAQ 1276
Cdd:PTZ00449 480 QFTQEIKkliKKSKKKLAPIEEEDSDKHDEPP--EGPEASGLPPKAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEV 557
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 1277 TPKSPP--EHYVQETPLMFSRCT----SVSSLDSFESRSIASSVQ-SEPCSGMVSGIISPSDLPDSPGQTMPPSRSKTPP 1349
Cdd:PTZ00449 558 GKKPGPakEHKPSKIPTLSKKPEfpkdPKHPKDPEEPKKPKRPRSaQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPP 637
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 1350 PPPQTAQTKR-EVPK----NKAPTAEKRESGPK------QAAVNAAVQRVQvlpdadtllhfaTESTPDGFSCSSSLSAL 1418
Cdd:PTZ00449 638 PPQRPSSPERpEGPKiiksPKPPKSPKPPFDPKfkekfyDDYLDAAAKSKE------------TKTTVVLDESFESILKE 705
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 1419 SLDEPFIQKDVELRIMPPVQENDNG------NETESEQPKESNENQEKEAEKTIDSEKDLLDDSDDDDIEILEECIISAM 1492
Cdd:PTZ00449 706 TLPETPGTPFTTPRPLPPKLPRDEEfpfepiGDPDAEQPDDIEFFTPPEEERTFFHETPADTPLPDILAEEFKEEDIHAE 785
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 1493 PTKSSRKAKKPAQTASKLPPPVARKPSqlpvyklLPSQNRLQPQKHVSFTPGDDMPRVYCVE--GTPINFSTATSLSDL- 1569
Cdd:PTZ00449 786 TGEPDEAMKRPDSPSEHEDKPPGDHPS-------LPKKRHRLDGLALSTTDLESDAGRIAKDasGKIVKLKRSKSFDDLt 858
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 1237937744 1570 TIESPPNELAAGEGVRGGAQSGEFEKRDTIPTEGRSTDEAQ 1610
Cdd:PTZ00449 859 TVEEAEEMGAEARKIVVDDDGTEADDEDTHPPEEKHKSEVR 899
|
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1166-1183 |
6.87e-03 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
:
Pssm-ID: 461781 Cd Length: 24 Bit Score: 36.20 E-value: 6.87e-03
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Arm_APC_u3 |
pfam16629 |
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ... |
641-928 |
1.19e-166 |
|
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
Pssm-ID: 435476 Cd Length: 293 Bit Score: 515.29 E-value: 1.19e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 641 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRSKQRHKQSLYGDYVFDTNRHDDN-- 718
Cdd:pfam16629 1 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNVYSEYVLDSGRHDDSvc 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 719 RSDNFNTGNMTVLSPYLNTTVLPSSSSSRG--SLDSSRSEKDRSLERERGIGLGNYHPATENPGTSSKR-GLQISTTAAQ 795
Cdd:pfam16629 81 RSDNFNTGNVTVLSPYLNTTVLPSSSSRDSrgNAESSRSEKDRSLDRERGAGLSNFHPATENSGNSSKRiGMQISTTAAQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 796 IAKVMEEVSAIHTSQEDRSSGSTTELHCVTDERNALRRSSAAHTHSNTYNFTKSENSNRTCSMPYAKLEYKRSSNDSLNS 875
Cdd:pfam16629 161 IAKVMEEVSSMHISQEDRSSGSTSDMHCMQDDRNSIRRSSTAHPHSNVYSFNKSESSNRPCPMPYMKMEYKRASNDSLNS 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1237937744 876 VSSSDGYGKRGQMKPSIESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDG 928
Cdd:pfam16629 241 VSSSDGYGKRGQMKPSVESYSEDDEGKFCSYGKYPADLAHKIHSANHMDDNDG 293
|
|
| APC_basic |
pfam05956 |
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ... |
2132-2477 |
3.68e-108 |
|
APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.
Pssm-ID: 428690 [Multi-domain] Cd Length: 336 Bit Score: 349.18 E-value: 3.68e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2132 SISRGRTMIHIPGVRNSSSSTSPVSKKGPPLKTPASKSPSEGQTATTS-PRGAKPSVKSELSPVARQTSQIGGSSKAPSR 2210
Cdd:pfam05956 1 VVFRGRTVIYMPGVKESQPSTSPPPKKTPPKTDAPAKNPNLGQQRSRSlHRLGKPSELADLSPPKRSATPPARISKAPSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2211 SGSRDSTPSRPAQQPLSRPIQSPGRNSISPGRNgisppnKLSQLPRTSSPSTASTKSSGSgKMSYTSPGRQMSQQNLTKQ 2290
Cdd:pfam05956 81 GSSRDSTPSRPPQKKLTSPSQSPGRLPGSGGRN------KLSPLPKTKSPARASTKKSGS-HKTQKSPVRIPFMQTPTKQ 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2291 TGLSKNASSI------PRSESASKGLNqmnngNGANKKVELSRMSSTKSSGSESDRSerpVLVRQSTFIKEAPSPTLRRK 2364
Cdd:pfam05956 154 TGLPRNPSPLvtnqpePRSESASKGLR-----SLPGKRLDLVRMSSARSSGSESDRS---GFLRQLTFIKESPSLLLRRR 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2365 LEESASfESLSPSSRPASPTRSQaqtpvlsPSLPDMSLSTHSSVQAGGWRKLPPNLSPTIEYNDGRPAKRHDIARSHSES 2444
Cdd:pfam05956 226 LELSAS-ESLSPSSQPASPRRSR-------PGLPAVFLCSSRCQELKGWRKQPPNPNSRAEPSDRPLTRRRPPRRTSSES 297
|
330 340 350
....*....|....*....|....*....|...
gi 1237937744 2445 PSRLPInRSGTWKREHSKHSSSLPRVSTWRRTG 2477
Cdd:pfam05956 298 PSRLPV-RNGTWKRETFKRYSSLPHINVWRRTG 329
|
|
| EB1_binding |
pfam05937 |
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the ... |
2579-2752 |
6.40e-89 |
|
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the microtubule-associating protein EB-1. At the C-terminus of the alignment is also a pfam00595 binding domain. A short motif in the middle of the region appears to be found in the APC2 proteins.
Pssm-ID: 399141 Cd Length: 174 Bit Score: 287.28 E-value: 6.40e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2579 RSGRSPTGNTPPVIDSVSEKANPNIKDSKDNQAKQNVGNGSVPMRTVGLENRLNSFIQVDAPDQKGTEIKPGQNNPVPVS 2658
Cdd:pfam05937 1 RSGRSPTGNTPPVIDSVPEKGIKDEKDSKDPQAKQNMGNGNVPVRTVGLENRLNSFIQSDSPDKKGTETKPLQNNPVPTP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2659 ETNESSIVERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVNNNTKKRDSKTDSTESSGTQ 2738
Cdd:pfam05937 81 ETNENPVSERTPFSSSSSSKHSSPSGAVAARVTPFNYNPSPRKSSADSSSARPSQIPTPVNNSTKKRDSKTESTDSSGNQ 160
|
170
....*....|....
gi 1237937744 2739 SPKRHSGSYLVTSV 2752
Cdd:pfam05937 161 SPKRHSGSYLVTSV 174
|
|
| APC_u5 |
pfam16630 |
Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of ... |
945-1044 |
1.90e-56 |
|
Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of natively unstructured sequence lying between the first and the second 15-residue beta-catenin binding motifs, APC_15aa, pfam05972, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
Pssm-ID: 406923 Cd Length: 100 Bit Score: 191.27 E-value: 1.90e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 945 LNSGRQSPSQNERWARPKHIIEDEIKQSEQRQSRNQSTTYPVYTESTDDKHLKFQPHFGQQECVSPYRSRGANGSETNRV 1024
Cdd:pfam16630 1 LNSGRQSPSQNERWARPKHIIEDEMKQSEQRQPRSQSTTYPVYTESGDDKHMKFQPRFGQQECVSPFRSRGSNGSEQSRV 80
|
90 100
....*....|....*....|
gi 1237937744 1025 GSNHGINQNVSQSLCQEDDY 1044
Cdd:pfam16630 81 GSSHGINQKVSQSLCQVDDY 100
|
|
| APC_u14 |
pfam16635 |
Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively ... |
1655-1748 |
9.81e-47 |
|
Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively unstructured sequence lying between the second SAMP pfam05924, and the fifth creatine-rich region, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
Pssm-ID: 435479 Cd Length: 94 Bit Score: 163.09 E-value: 9.81e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 1655 IMDQVQQASASSSAPNKNQLDGKKKKPTSPVKPIPQNTEYRTRVRKNADSKNNLNAERVFSDNKDSKKQNLKNNSKVFND 1734
Cdd:pfam16635 1 IMDQIQQASAASSGGSKSQQDGEKKKPTSPVKPMPQSSEYRARVRKNTESKNNLNSERSYPDNKESKKQNLKNNSRDFND 80
|
90
....*....|....
gi 1237937744 1735 KLPNNEDRVRGSFA 1748
Cdd:pfam16635 81 KLPNNEERTRGSFA 94
|
|
| APC_u9 |
pfam16633 |
Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of ... |
1192-1277 |
2.31e-35 |
|
Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of natively unstructured sequence lying between the first and second APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
Pssm-ID: 435478 Cd Length: 89 Bit Score: 130.38 E-value: 2.31e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 1192 AEDEI-GCNQTTQEADSANTLQIAEIKEKIGTRSAEDPVSEVPAVSQHPRTKSSRLQGSSLS-SESARHKAVEFSSGAKS 1269
Cdd:pfam16633 2 AEDEIeGRDQATRSTDNYNTLQITELKENSGAVSTEQTVSEVPSSSQHIRTKPNRLQASNLSpSDSSRHKAVEFSSGAKS 81
|
....*...
gi 1237937744 1270 PSKSGAQT 1277
Cdd:pfam16633 82 PSKSGAQT 89
|
|
| APC_u15 |
pfam16636 |
Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of ... |
1782-1856 |
3.89e-31 |
|
Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of natively unstructured sequence lying between the fifth and sixth creatine-rich, APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
Pssm-ID: 435480 Cd Length: 81 Bit Score: 118.04 E-value: 3.89e-31
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1237937744 1782 DLSREKAELRKAKENKESEAKVTSHTELTSNQQSANKTQAIAKQPINRGQPKPILQKQSTFPQSSKDIPDRGAAT 1856
Cdd:pfam16636 7 DLSREKAELRKGKETKETETKVTSHIEQPSNQQSTNRTQACQKHPPNRGQPKPLLQKQTTFPQSSKDIPDRGAAT 81
|
|
| APC_rep |
pfam18797 |
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ... |
317-375 |
7.60e-31 |
|
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.
Pssm-ID: 465870 Cd Length: 74 Bit Score: 117.26 E-value: 7.60e-31
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 1237937744 317 HLGTKIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAVCVLMKLSFDEEHRHAM 375
Cdd:pfam18797 16 HLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
|
|
| APC_u13 |
pfam16634 |
Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively ... |
1571-1624 |
1.75e-24 |
|
Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively unstructured sequence lying between the fourth creatine-rich region, APC_crr, pfam05923, and the SAMP pfam05924, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
Pssm-ID: 406927 Cd Length: 54 Bit Score: 98.33 E-value: 1.75e-24
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 1237937744 1571 IESPPNELAAGEGVRGGAQSGEFEKRDTIPTEGRSTDEAQGGKTSSVTIPELDD 1624
Cdd:pfam16634 1 IESPPNELANAESTGTGAESAEFEKRDTIPTEGRSTDDAQRGKKSNITTSALDD 54
|
|
| Suppressor_APC |
pfam11414 |
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ... |
137-217 |
1.77e-22 |
|
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.
Pssm-ID: 463275 Cd Length: 82 Bit Score: 93.47 E-value: 1.77e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 137 SRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTE-NFSLQTDMTRRQLEYEARQIRVAMEEQLG 215
Cdd:pfam11414 1 DYNMLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGtYFDYGSDAQQERLEFLLARIQEVNRCLGG 80
|
..
gi 1237937744 216 TC 217
Cdd:pfam11414 81 LI 82
|
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1546-1569 |
1.52e-07 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
Pssm-ID: 461781 Cd Length: 24 Bit Score: 49.30 E-value: 1.52e-07
|
| ARM |
smart00185 |
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ... |
558-598 |
4.46e-07 |
|
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.
Pssm-ID: 214547 [Multi-domain] Cd Length: 41 Bit Score: 48.19 E-value: 4.46e-07
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1237937744 558 NEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSA 598
Cdd:smart00185 1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
|
|
| Arm |
pfam00514 |
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
558-598 |
6.06e-07 |
|
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.
Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 47.83 E-value: 6.06e-07
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1237937744 558 NEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSA 598
Cdd:pfam00514 1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
2160-2473 |
1.54e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 54.17 E-value: 1.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2160 PPLKTPASKsPSEGQTATTSPRGAKPSVKSE----LSPVARQTSQIGGSSKAPSRSGSRDSTPSRPAQQPLSRPIQSPGR 2235
Cdd:PHA03247 2703 PPPPTPEPA-PHALVSATPLPPGPAAARQASpalpAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR 2781
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2236 NSISPGRNGISPPNKLSQLPRTSSPSTASTKSSGSGKMSYTSPGrqmsqqnltkqTGLSKNASSIPRSESASKGLNQ--M 2313
Cdd:PHA03247 2782 RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPA-----------GPLPPPTSAQPTAPPPPPGPPPpsL 2850
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2314 NNGNGANKKVELSRMSSTKSSGSESDRSERPVLVRqstfikeAPSPTLRRKLEESA-SFESLSPSSRPASPTRSQAQTPV 2392
Cdd:PHA03247 2851 PLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRR-------LARPAVSRSTESFAlPPDQPERPPQPQAPPPPQPQPQP 2923
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2393 LSPSLPDMSLSTHSSVQAggwrKLPPNLSPTieyNDGRPAKRHDIARSHSESPSRLPINRSGTWK----RE------HSK 2462
Cdd:PHA03247 2924 PPPPQPQPPPPPPPRPQP----PLAPTTDPA---GAGEPSGAVPQPWLGALVPGRVAVPRFRVPQpapsREapasstPPL 2996
|
330
....*....|.
gi 1237937744 2463 HSSSLPRVSTW 2473
Cdd:PHA03247 2997 TGHSLSRVSSW 3007
|
|
| SAMP |
pfam05924 |
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1942-1961 |
3.16e-05 |
|
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.
Pssm-ID: 461782 Cd Length: 22 Bit Score: 42.58 E-value: 3.16e-05
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
144-276 |
1.10e-04 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 47.84 E-value: 1.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 144 LEELEKERSLLLADLDKEEKEKDWY--YAQLQNLTKRIDSLP---------LTENFSLQTDM---------TRRQLEYEA 203
Cdd:COG4717 104 LEELEAELEELREELEKLEKLLQLLplYQELEALEAELAELPerleeleerLEELRELEEELeeleaelaeLQEELEELL 183
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1237937744 204 RQIRVAMEEQLgtcQDMEKRAQRRIARIQQIEKDILRIRQLLQsQATEAERSSQNKHETGsHDAERQNEGQGV 276
Cdd:COG4717 184 EQLSLATEEEL---QDLAEELEELQQRLAELEEELEEAQEELE-ELEEELEQLENELEAA-ALEERLKEARLL 251
|
|
| ARM |
smart00185 |
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ... |
421-462 |
5.08e-04 |
|
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.
Pssm-ID: 214547 [Multi-domain] Cd Length: 41 Bit Score: 39.72 E-value: 5.08e-04
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 1237937744 421 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLSW 462
Cdd:smart00185 1 DDENKQAVVDA-GGLPALVELLKSEDEEVVKEAAWALSNLSS 41
|
|
| Arm |
pfam00514 |
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
421-461 |
5.85e-04 |
|
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.
Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 39.36 E-value: 5.85e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1237937744 421 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLS 461
Cdd:pfam00514 1 SPENKQAVIEA-GAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
|
|
| Arm |
pfam00514 |
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
600-640 |
6.78e-04 |
|
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.
Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 39.36 E-value: 6.78e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1237937744 600 NPKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMA 640
Cdd:pfam00514 1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
|
|
| SAMP |
pfam05924 |
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1625-1646 |
1.21e-03 |
|
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.
Pssm-ID: 461782 Cd Length: 22 Bit Score: 38.34 E-value: 1.21e-03
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
130-270 |
1.39e-03 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 44.28 E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 130 RRGFVNGSRESTGY--------LEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLpltenfslqtdmtrRQLEY 201
Cdd:TIGR02168 657 PGGVITGGSAKTNSsilerrreIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQL--------------RKELE 722
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1237937744 202 EARQIRVAMEEQLGTcqdMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQ 270
Cdd:TIGR02168 723 ELSRQISALRKDLAR---LEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELE 788
|
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1280-1302 |
3.60e-03 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
Pssm-ID: 461781 Cd Length: 24 Bit Score: 36.97 E-value: 3.60e-03
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
1200-1610 |
4.62e-03 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 42.75 E-value: 4.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 1200 QTTQEAD---SANTLQIAEIKEKIGTRSAEDPvsEVPAVSQHPRTKSSRLQGSSLSSESARHKAVEFSSGAKSPSKSGAQ 1276
Cdd:PTZ00449 480 QFTQEIKkliKKSKKKLAPIEEEDSDKHDEPP--EGPEASGLPPKAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEV 557
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 1277 TPKSPP--EHYVQETPLMFSRCT----SVSSLDSFESRSIASSVQ-SEPCSGMVSGIISPSDLPDSPGQTMPPSRSKTPP 1349
Cdd:PTZ00449 558 GKKPGPakEHKPSKIPTLSKKPEfpkdPKHPKDPEEPKKPKRPRSaQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPP 637
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 1350 PPPQTAQTKR-EVPK----NKAPTAEKRESGPK------QAAVNAAVQRVQvlpdadtllhfaTESTPDGFSCSSSLSAL 1418
Cdd:PTZ00449 638 PPQRPSSPERpEGPKiiksPKPPKSPKPPFDPKfkekfyDDYLDAAAKSKE------------TKTTVVLDESFESILKE 705
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 1419 SLDEPFIQKDVELRIMPPVQENDNG------NETESEQPKESNENQEKEAEKTIDSEKDLLDDSDDDDIEILEECIISAM 1492
Cdd:PTZ00449 706 TLPETPGTPFTTPRPLPPKLPRDEEfpfepiGDPDAEQPDDIEFFTPPEEERTFFHETPADTPLPDILAEEFKEEDIHAE 785
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 1493 PTKSSRKAKKPAQTASKLPPPVARKPSqlpvyklLPSQNRLQPQKHVSFTPGDDMPRVYCVE--GTPINFSTATSLSDL- 1569
Cdd:PTZ00449 786 TGEPDEAMKRPDSPSEHEDKPPGDHPS-------LPKKRHRLDGLALSTTDLESDAGRIAKDasGKIVKLKRSKSFDDLt 858
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 1237937744 1570 TIESPPNELAAGEGVRGGAQSGEFEKRDTIPTEGRSTDEAQ 1610
Cdd:PTZ00449 859 TVEEAEEMGAEARKIVVDDDGTEADDEDTHPPEEKHKSEVR 899
|
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1166-1183 |
6.87e-03 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
Pssm-ID: 461781 Cd Length: 24 Bit Score: 36.20 E-value: 6.87e-03
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Arm_APC_u3 |
pfam16629 |
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ... |
641-928 |
1.19e-166 |
|
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
Pssm-ID: 435476 Cd Length: 293 Bit Score: 515.29 E-value: 1.19e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 641 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRSKQRHKQSLYGDYVFDTNRHDDN-- 718
Cdd:pfam16629 1 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNVYSEYVLDSGRHDDSvc 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 719 RSDNFNTGNMTVLSPYLNTTVLPSSSSSRG--SLDSSRSEKDRSLERERGIGLGNYHPATENPGTSSKR-GLQISTTAAQ 795
Cdd:pfam16629 81 RSDNFNTGNVTVLSPYLNTTVLPSSSSRDSrgNAESSRSEKDRSLDRERGAGLSNFHPATENSGNSSKRiGMQISTTAAQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 796 IAKVMEEVSAIHTSQEDRSSGSTTELHCVTDERNALRRSSAAHTHSNTYNFTKSENSNRTCSMPYAKLEYKRSSNDSLNS 875
Cdd:pfam16629 161 IAKVMEEVSSMHISQEDRSSGSTSDMHCMQDDRNSIRRSSTAHPHSNVYSFNKSESSNRPCPMPYMKMEYKRASNDSLNS 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1237937744 876 VSSSDGYGKRGQMKPSIESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDG 928
Cdd:pfam16629 241 VSSSDGYGKRGQMKPSVESYSEDDEGKFCSYGKYPADLAHKIHSANHMDDNDG 293
|
|
| APC_basic |
pfam05956 |
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ... |
2132-2477 |
3.68e-108 |
|
APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.
Pssm-ID: 428690 [Multi-domain] Cd Length: 336 Bit Score: 349.18 E-value: 3.68e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2132 SISRGRTMIHIPGVRNSSSSTSPVSKKGPPLKTPASKSPSEGQTATTS-PRGAKPSVKSELSPVARQTSQIGGSSKAPSR 2210
Cdd:pfam05956 1 VVFRGRTVIYMPGVKESQPSTSPPPKKTPPKTDAPAKNPNLGQQRSRSlHRLGKPSELADLSPPKRSATPPARISKAPSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2211 SGSRDSTPSRPAQQPLSRPIQSPGRNSISPGRNgisppnKLSQLPRTSSPSTASTKSSGSgKMSYTSPGRQMSQQNLTKQ 2290
Cdd:pfam05956 81 GSSRDSTPSRPPQKKLTSPSQSPGRLPGSGGRN------KLSPLPKTKSPARASTKKSGS-HKTQKSPVRIPFMQTPTKQ 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2291 TGLSKNASSI------PRSESASKGLNqmnngNGANKKVELSRMSSTKSSGSESDRSerpVLVRQSTFIKEAPSPTLRRK 2364
Cdd:pfam05956 154 TGLPRNPSPLvtnqpePRSESASKGLR-----SLPGKRLDLVRMSSARSSGSESDRS---GFLRQLTFIKESPSLLLRRR 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2365 LEESASfESLSPSSRPASPTRSQaqtpvlsPSLPDMSLSTHSSVQAGGWRKLPPNLSPTIEYNDGRPAKRHDIARSHSES 2444
Cdd:pfam05956 226 LELSAS-ESLSPSSQPASPRRSR-------PGLPAVFLCSSRCQELKGWRKQPPNPNSRAEPSDRPLTRRRPPRRTSSES 297
|
330 340 350
....*....|....*....|....*....|...
gi 1237937744 2445 PSRLPInRSGTWKREHSKHSSSLPRVSTWRRTG 2477
Cdd:pfam05956 298 PSRLPV-RNGTWKRETFKRYSSLPHINVWRRTG 329
|
|
| EB1_binding |
pfam05937 |
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the ... |
2579-2752 |
6.40e-89 |
|
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the microtubule-associating protein EB-1. At the C-terminus of the alignment is also a pfam00595 binding domain. A short motif in the middle of the region appears to be found in the APC2 proteins.
Pssm-ID: 399141 Cd Length: 174 Bit Score: 287.28 E-value: 6.40e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2579 RSGRSPTGNTPPVIDSVSEKANPNIKDSKDNQAKQNVGNGSVPMRTVGLENRLNSFIQVDAPDQKGTEIKPGQNNPVPVS 2658
Cdd:pfam05937 1 RSGRSPTGNTPPVIDSVPEKGIKDEKDSKDPQAKQNMGNGNVPVRTVGLENRLNSFIQSDSPDKKGTETKPLQNNPVPTP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2659 ETNESSIVERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVNNNTKKRDSKTDSTESSGTQ 2738
Cdd:pfam05937 81 ETNENPVSERTPFSSSSSSKHSSPSGAVAARVTPFNYNPSPRKSSADSSSARPSQIPTPVNNSTKKRDSKTESTDSSGNQ 160
|
170
....*....|....
gi 1237937744 2739 SPKRHSGSYLVTSV 2752
Cdd:pfam05937 161 SPKRHSGSYLVTSV 174
|
|
| APC_u5 |
pfam16630 |
Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of ... |
945-1044 |
1.90e-56 |
|
Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of natively unstructured sequence lying between the first and the second 15-residue beta-catenin binding motifs, APC_15aa, pfam05972, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
Pssm-ID: 406923 Cd Length: 100 Bit Score: 191.27 E-value: 1.90e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 945 LNSGRQSPSQNERWARPKHIIEDEIKQSEQRQSRNQSTTYPVYTESTDDKHLKFQPHFGQQECVSPYRSRGANGSETNRV 1024
Cdd:pfam16630 1 LNSGRQSPSQNERWARPKHIIEDEMKQSEQRQPRSQSTTYPVYTESGDDKHMKFQPRFGQQECVSPFRSRGSNGSEQSRV 80
|
90 100
....*....|....*....|
gi 1237937744 1025 GSNHGINQNVSQSLCQEDDY 1044
Cdd:pfam16630 81 GSSHGINQKVSQSLCQVDDY 100
|
|
| APC_u14 |
pfam16635 |
Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively ... |
1655-1748 |
9.81e-47 |
|
Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively unstructured sequence lying between the second SAMP pfam05924, and the fifth creatine-rich region, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
Pssm-ID: 435479 Cd Length: 94 Bit Score: 163.09 E-value: 9.81e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 1655 IMDQVQQASASSSAPNKNQLDGKKKKPTSPVKPIPQNTEYRTRVRKNADSKNNLNAERVFSDNKDSKKQNLKNNSKVFND 1734
Cdd:pfam16635 1 IMDQIQQASAASSGGSKSQQDGEKKKPTSPVKPMPQSSEYRARVRKNTESKNNLNSERSYPDNKESKKQNLKNNSRDFND 80
|
90
....*....|....
gi 1237937744 1735 KLPNNEDRVRGSFA 1748
Cdd:pfam16635 81 KLPNNEERTRGSFA 94
|
|
| APC_u9 |
pfam16633 |
Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of ... |
1192-1277 |
2.31e-35 |
|
Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of natively unstructured sequence lying between the first and second APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
Pssm-ID: 435478 Cd Length: 89 Bit Score: 130.38 E-value: 2.31e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 1192 AEDEI-GCNQTTQEADSANTLQIAEIKEKIGTRSAEDPVSEVPAVSQHPRTKSSRLQGSSLS-SESARHKAVEFSSGAKS 1269
Cdd:pfam16633 2 AEDEIeGRDQATRSTDNYNTLQITELKENSGAVSTEQTVSEVPSSSQHIRTKPNRLQASNLSpSDSSRHKAVEFSSGAKS 81
|
....*...
gi 1237937744 1270 PSKSGAQT 1277
Cdd:pfam16633 82 PSKSGAQT 89
|
|
| APC_u15 |
pfam16636 |
Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of ... |
1782-1856 |
3.89e-31 |
|
Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of natively unstructured sequence lying between the fifth and sixth creatine-rich, APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
Pssm-ID: 435480 Cd Length: 81 Bit Score: 118.04 E-value: 3.89e-31
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1237937744 1782 DLSREKAELRKAKENKESEAKVTSHTELTSNQQSANKTQAIAKQPINRGQPKPILQKQSTFPQSSKDIPDRGAAT 1856
Cdd:pfam16636 7 DLSREKAELRKGKETKETETKVTSHIEQPSNQQSTNRTQACQKHPPNRGQPKPLLQKQTTFPQSSKDIPDRGAAT 81
|
|
| APC_rep |
pfam18797 |
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ... |
317-375 |
7.60e-31 |
|
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.
Pssm-ID: 465870 Cd Length: 74 Bit Score: 117.26 E-value: 7.60e-31
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 1237937744 317 HLGTKIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAVCVLMKLSFDEEHRHAM 375
Cdd:pfam18797 16 HLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
|
|
| APC_u13 |
pfam16634 |
Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively ... |
1571-1624 |
1.75e-24 |
|
Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively unstructured sequence lying between the fourth creatine-rich region, APC_crr, pfam05923, and the SAMP pfam05924, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
Pssm-ID: 406927 Cd Length: 54 Bit Score: 98.33 E-value: 1.75e-24
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 1237937744 1571 IESPPNELAAGEGVRGGAQSGEFEKRDTIPTEGRSTDEAQGGKTSSVTIPELDD 1624
Cdd:pfam16634 1 IESPPNELANAESTGTGAESAEFEKRDTIPTEGRSTDDAQRGKKSNITTSALDD 54
|
|
| Suppressor_APC |
pfam11414 |
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ... |
137-217 |
1.77e-22 |
|
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.
Pssm-ID: 463275 Cd Length: 82 Bit Score: 93.47 E-value: 1.77e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 137 SRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTE-NFSLQTDMTRRQLEYEARQIRVAMEEQLG 215
Cdd:pfam11414 1 DYNMLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGtYFDYGSDAQQERLEFLLARIQEVNRCLGG 80
|
..
gi 1237937744 216 TC 217
Cdd:pfam11414 81 LI 82
|
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1546-1569 |
1.52e-07 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
Pssm-ID: 461781 Cd Length: 24 Bit Score: 49.30 E-value: 1.52e-07
|
| ARM |
smart00185 |
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ... |
558-598 |
4.46e-07 |
|
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.
Pssm-ID: 214547 [Multi-domain] Cd Length: 41 Bit Score: 48.19 E-value: 4.46e-07
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1237937744 558 NEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSA 598
Cdd:smart00185 1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
|
|
| Arm |
pfam00514 |
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
558-598 |
6.06e-07 |
|
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.
Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 47.83 E-value: 6.06e-07
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1237937744 558 NEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSA 598
Cdd:pfam00514 1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
2160-2473 |
1.54e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 54.17 E-value: 1.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2160 PPLKTPASKsPSEGQTATTSPRGAKPSVKSE----LSPVARQTSQIGGSSKAPSRSGSRDSTPSRPAQQPLSRPIQSPGR 2235
Cdd:PHA03247 2703 PPPPTPEPA-PHALVSATPLPPGPAAARQASpalpAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR 2781
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2236 NSISPGRNGISPPNKLSQLPRTSSPSTASTKSSGSGKMSYTSPGrqmsqqnltkqTGLSKNASSIPRSESASKGLNQ--M 2313
Cdd:PHA03247 2782 RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPA-----------GPLPPPTSAQPTAPPPPPGPPPpsL 2850
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2314 NNGNGANKKVELSRMSSTKSSGSESDRSERPVLVRqstfikeAPSPTLRRKLEESA-SFESLSPSSRPASPTRSQAQTPV 2392
Cdd:PHA03247 2851 PLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRR-------LARPAVSRSTESFAlPPDQPERPPQPQAPPPPQPQPQP 2923
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2393 LSPSLPDMSLSTHSSVQAggwrKLPPNLSPTieyNDGRPAKRHDIARSHSESPSRLPINRSGTWK----RE------HSK 2462
Cdd:PHA03247 2924 PPPPQPQPPPPPPPRPQP----PLAPTTDPA---GAGEPSGAVPQPWLGALVPGRVAVPRFRVPQpapsREapasstPPL 2996
|
330
....*....|.
gi 1237937744 2463 HSSSLPRVSTW 2473
Cdd:PHA03247 2997 TGHSLSRVSSW 3007
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
2165-2310 |
9.59e-06 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 51.33 E-value: 9.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2165 PASKSPSEGQTATTSPRGAKPSVKSELSPVA----RQTSQIGGSSKAPSRSGSRDSTPSRPAQQPLSRPIQSPGRNSISP 2240
Cdd:PHA03307 278 PSSRPGPASSSSSPRERSPSPSPSSPGSGPApsspRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPP 357
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2241 GRNGISPPNKLSQlPRTSSPSTASTKSSGSGKMSYTSPGRQMSQQNLTKQTGLSKNASSIPRSESASKGL 2310
Cdd:PHA03307 358 PPADPSSPRKRPR-PSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDAGAASGAF 426
|
|
| SAMP |
pfam05924 |
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1942-1961 |
3.16e-05 |
|
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.
Pssm-ID: 461782 Cd Length: 22 Bit Score: 42.58 E-value: 3.16e-05
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
2158-2453 |
6.59e-05 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 48.63 E-value: 6.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2158 KGPPLKTPASKSPSEGQTATTSPRGAKPSVKSELSPVARQTSQIGGSSKAPSRSGSRDSTPSRPAQQP---LSRPIQSPG 2234
Cdd:PHA03307 101 AREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASsrqAALPLSSPE 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2235 RNSISPGRNGISPPNKLSQLPRTSSP----STASTKSSGSGKMSYTSPGRQMSQQNLTKQTGLSKNASSIPRSE----SA 2306
Cdd:PHA03307 181 ETARAPSSPPAEPPPSTPPAAASPRPprrsSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENEcplpRP 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2307 SKGLNQMNNGNGANKKVELSRMSSTKSSGSESDRSERPVLVRQSTfikeAPSPTLRRKLEE--------SASFESLSPSS 2378
Cdd:PHA03307 261 APITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGS----GPAPSSPRASSSssssressSSSTSSSSESS 336
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1237937744 2379 RPASPTRSQAQTPVLSPSLPDMSLSTHSSVQAGgwRKLPPNLSPTIEYNDG-RPAKRHDIARSH--SESPSRLPINRS 2453
Cdd:PHA03307 337 RGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRP--RPSRAPSSPAASAGRPtRRRARAAVAGRArrRDATGRFPAGRP 412
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
144-276 |
1.10e-04 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 47.84 E-value: 1.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 144 LEELEKERSLLLADLDKEEKEKDWY--YAQLQNLTKRIDSLP---------LTENFSLQTDM---------TRRQLEYEA 203
Cdd:COG4717 104 LEELEAELEELREELEKLEKLLQLLplYQELEALEAELAELPerleeleerLEELRELEEELeeleaelaeLQEELEELL 183
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1237937744 204 RQIRVAMEEQLgtcQDMEKRAQRRIARIQQIEKDILRIRQLLQsQATEAERSSQNKHETGsHDAERQNEGQGV 276
Cdd:COG4717 184 EQLSLATEEEL---QDLAEELEELQQRLAELEEELEEAQEELE-ELEEELEQLENELEAA-ALEERLKEARLL 251
|
|
| ARM |
smart00185 |
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ... |
421-462 |
5.08e-04 |
|
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.
Pssm-ID: 214547 [Multi-domain] Cd Length: 41 Bit Score: 39.72 E-value: 5.08e-04
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 1237937744 421 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLSW 462
Cdd:smart00185 1 DDENKQAVVDA-GGLPALVELLKSEDEEVVKEAAWALSNLSS 41
|
|
| Arm |
pfam00514 |
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
421-461 |
5.85e-04 |
|
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.
Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 39.36 E-value: 5.85e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1237937744 421 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLS 461
Cdd:pfam00514 1 SPENKQAVIEA-GAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
|
|
| Arm |
pfam00514 |
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
600-640 |
6.78e-04 |
|
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.
Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 39.36 E-value: 6.78e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1237937744 600 NPKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMA 640
Cdd:pfam00514 1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
145-272 |
7.16e-04 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 45.31 E-value: 7.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 145 EELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLpltenfslQTDMTRRQLEYE-ARQIRVAMEEQLgtcQDMEKR 223
Cdd:COG1196 221 ELKELEAELLLLKLRELEAELEELEAELEELEAELEEL--------EAELAELEAELEeLRLELEELELEL---EEAQAE 289
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1237937744 224 AQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQNE 272
Cdd:COG1196 290 EYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEE 338
|
|
| SAMP |
pfam05924 |
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1625-1646 |
1.21e-03 |
|
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.
Pssm-ID: 461782 Cd Length: 22 Bit Score: 38.34 E-value: 1.21e-03
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
130-270 |
1.39e-03 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 44.28 E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 130 RRGFVNGSRESTGY--------LEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLpltenfslqtdmtrRQLEY 201
Cdd:TIGR02168 657 PGGVITGGSAKTNSsilerrreIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQL--------------RKELE 722
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1237937744 202 EARQIRVAMEEQLGTcqdMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQ 270
Cdd:TIGR02168 723 ELSRQISALRKDLAR---LEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELE 788
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
144-269 |
1.48e-03 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 44.29 E-value: 1.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 144 LEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSL------------PLTENFSLQTDMTRRQLEYEARQIRVAME 211
Cdd:TIGR02169 232 KEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIeqlleelnkkikDLGEEEQLRVKEKIGELEAEIASLERSIA 311
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1237937744 212 EqlgtCQDMEKRAQRRIARIQ-QIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAER 269
Cdd:TIGR02169 312 E----KERELEDAEERLAKLEaEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEEL 366
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
2163-2423 |
1.55e-03 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 43.80 E-value: 1.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2163 KTPASKSPSEGQTATTSPRGAKPsvkselSPVARQTSQIGGSSKAPSRSGSRDSTPSRPAQQPLSRPIQSPGRNSISPgr 2242
Cdd:pfam17823 151 RANASAAPRAAIAAASAPHAASP------APRTAASSTTAASSTTAASSAPTTAASSAPATLTPARGISTAATATGHP-- 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2243 ngiSPPNKLSQLPrTSSPStASTKSSGSGKMSYTSPGRQMSQQNLTKQTGLSKNASSiPRSESASKGLNQMNNGNGANKk 2322
Cdd:pfam17823 223 ---AAGTALAAVG-NSSPA-AGTVTAAVGTVTPAALATLAAAAGTVASAAGTINMGD-PHARRLSPAKHMPSDTMARNP- 295
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2323 veLSRMSSTKSSGSESDRSERPVLvrqSTFIKEAPSPTlRRKLEESASFESLSPSSRPASPTRSQAQTPVLSPsLPDMSL 2402
Cdd:pfam17823 296 --AAPMGAQAQGPIIQVSTDQPVH---NTAGEPTPSPS-NTTLEPNTPKSVASTNLAVVTTTKAQAKEPSASP-VPVLHT 368
|
250 260
....*....|....*....|.
gi 1237937744 2403 STHSSVQAGGWRKLPPNLSPT 2423
Cdd:pfam17823 369 SMIPEVEATSPTTQPSPLLPT 389
|
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1280-1302 |
3.60e-03 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
Pssm-ID: 461781 Cd Length: 24 Bit Score: 36.97 E-value: 3.60e-03
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
144-258 |
4.03e-03 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 42.06 E-value: 4.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 144 LEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLpltenfslqtdmtrrqleyeARQIRvAMEEQLgtcQDMEKR 223
Cdd:COG4942 29 LEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAAL--------------------ARRIR-ALEQEL---AALEAE 84
|
90 100 110
....*....|....*....|....*....|....*
gi 1237937744 224 AQRRIARIQQIEKDILRIRQLLQSQATEAERSSQN 258
Cdd:COG4942 85 LAELEKEIAELRAELEAQKEELAELLRALYRLGRQ 119
|
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
1200-1610 |
4.62e-03 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 42.75 E-value: 4.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 1200 QTTQEAD---SANTLQIAEIKEKIGTRSAEDPvsEVPAVSQHPRTKSSRLQGSSLSSESARHKAVEFSSGAKSPSKSGAQ 1276
Cdd:PTZ00449 480 QFTQEIKkliKKSKKKLAPIEEEDSDKHDEPP--EGPEASGLPPKAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEV 557
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 1277 TPKSPP--EHYVQETPLMFSRCT----SVSSLDSFESRSIASSVQ-SEPCSGMVSGIISPSDLPDSPGQTMPPSRSKTPP 1349
Cdd:PTZ00449 558 GKKPGPakEHKPSKIPTLSKKPEfpkdPKHPKDPEEPKKPKRPRSaQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPP 637
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 1350 PPPQTAQTKR-EVPK----NKAPTAEKRESGPK------QAAVNAAVQRVQvlpdadtllhfaTESTPDGFSCSSSLSAL 1418
Cdd:PTZ00449 638 PPQRPSSPERpEGPKiiksPKPPKSPKPPFDPKfkekfyDDYLDAAAKSKE------------TKTTVVLDESFESILKE 705
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 1419 SLDEPFIQKDVELRIMPPVQENDNG------NETESEQPKESNENQEKEAEKTIDSEKDLLDDSDDDDIEILEECIISAM 1492
Cdd:PTZ00449 706 TLPETPGTPFTTPRPLPPKLPRDEEfpfepiGDPDAEQPDDIEFFTPPEEERTFFHETPADTPLPDILAEEFKEEDIHAE 785
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 1493 PTKSSRKAKKPAQTASKLPPPVARKPSqlpvyklLPSQNRLQPQKHVSFTPGDDMPRVYCVE--GTPINFSTATSLSDL- 1569
Cdd:PTZ00449 786 TGEPDEAMKRPDSPSEHEDKPPGDHPS-------LPKKRHRLDGLALSTTDLESDAGRIAKDasGKIVKLKRSKSFDDLt 858
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 1237937744 1570 TIESPPNELAAGEGVRGGAQSGEFEKRDTIPTEGRSTDEAQ 1610
Cdd:PTZ00449 859 TVEEAEEMGAEARKIVVDDDGTEADDEDTHPPEEKHKSEVR 899
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
2161-2477 |
6.64e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 42.08 E-value: 6.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2161 PLKTPASKSPSEGQTATTSPRGAKPSVKSELSPVARQTSQiGGSSKAPSRSGsrDSTPSRPAQQPLSRPIQSPGRNSISP 2240
Cdd:PHA03307 63 DRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAR-EGSPTPPGPSS--PDPPPPTPPPASPPPSPAPDLSEMLR 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2241 GRNGISPPNKLSQLPRTSSPS-TASTKSSGSGKM---------SYTSPGRQMSQQNLTKQTGLSKNASSIPRSESASKGL 2310
Cdd:PHA03307 140 PVGSPGPPPAASPPAAGASPAaVASDAASSRQAAlplsspeetARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASS 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2311 NQMNNGNGANKKVELSRMSSTKSSGSESD---RSERPVLVRQSTfikeaPSPTLRRKLEESASFESLSPSSRPASPTRSQ 2387
Cdd:PHA03307 220 PAPAPGRSAADDAGASSSDSSSSESSGCGwgpENECPLPRPAPI-----TLPTRIWEASGWNGPSSRPGPASSSSSPRER 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2388 AqtPVLSPSLPDMSLSTHSSVQAGGWRKLPP-NLSPTIEYNDGRPAKRHDIARSHSESPS----RLPINRSGTWKREHSK 2462
Cdd:PHA03307 295 S--PSPSPSSPGSGPAPSSPRASSSSSSSREsSSSSTSSSSESSRGAAVSPGPSPSRSPSpsrpPPPADPSSPRKRPRPS 372
|
330
....*....|....*
gi 1237937744 2463 HSSSLPRVSTWRRTG 2477
Cdd:PHA03307 373 RAPSSPAASAGRPTR 387
|
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1166-1183 |
6.87e-03 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
Pssm-ID: 461781 Cd Length: 24 Bit Score: 36.20 E-value: 6.87e-03
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
2159-2449 |
8.41e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 41.85 E-value: 8.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2159 GPPLKTPASKSPSEGQTATTSPRGAKPSvkselsPVARQTSqIGGSSKAPSRSGSRDSTPSRPAQQPLSRPIQSPGRNSI 2238
Cdd:PHA03247 2603 DDRGDPRGPAPPSPLPPDTHAPDPPPPS------PSPAANE-PDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQ 2675
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2239 SPgrngiSPPNKLSQ--LPRTSSPSTASTKSSGSGKMSYTSPGRQMSQQNLTKQTGLSKNASSIPRSESASKGLNQMNNG 2316
Cdd:PHA03247 2676 AS-----SPPQRPRRraARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPAT 2750
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937744 2317 NGANKKVE--------LSRMSSTKSSGSESDRSERPVLVRQSTFIKEAPSPT--LRRKLEESASFESLSPSSRPAS---- 2382
Cdd:PHA03247 2751 PGGPARPArppttagpPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWdpADPPAAVLAPAAALPPAASPAGplpp 2830
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1237937744 2383 PTRSQAQTPVLSPSLPDMSLSTHSSVQAGG--WRKLPPNLSPTIEYNDGRPAKRHDIARSHSESPSRLP 2449
Cdd:PHA03247 2831 PTSAQPTAPPPPPGPPPPSLPLGGSVAPGGdvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFA 2899
|
|
| |
