BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938258  16 HPTGLLCKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRNSQHYTLDFLSPKTFQQILEYAYTATLQAK 95
Cdd:cd18205     1 HPTGLLHKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRNSQHYTLDFLSPKTFQQILEYAYTATLQAK 80

                          90       100
                  ....*....|....*....|....*..
gi 1237938258  96 AEDLDDLLYAAEILEIEYLEEQCLKML 122
Cdd:cd18205    81 VEDLDDLLYAAEILEIEYLEEQCLKIL 107

transcriptional regulator ICP4; Provisional

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938258  177 PGPMVDQSPSVSTSFGLSAMSPTKAAVDSLMTIGQSLLQGTLQPPAGPEEPTlagGGRHPGVAEVKTEMMQ--VDEVPSQ 254
Cdd:PHA03307   204 PRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENEC---PLPRPAPITLPTRIWEasGWNGPSS 280

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1237938258  255 D-SPGAAESSISGGMGDKVEERGKEGPGTPTRSSVITSARELHYGREESAEQVPPPAEAGqAPTGRPEHPAPPP 327
Cdd:PHA03307   281 RpGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAA-VSPGPSPSRSPSP 353

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938258  16 HPTGLLCKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRNSQHYTLDFLSPKTFQQILEYAYTATLQAK 95
Cdd:cd18205     1 HPTGLLHKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRNSQHYTLDFLSPKTFQQILEYAYTATLQAK 80

                          90       100
                  ....*....|....*....|....*..
gi 1237938258  96 AEDLDDLLYAAEILEIEYLEEQCLKML 122
Cdd:cd18205    81 VEDLDDLLYAAEILEIEYLEEQCLKIL 107

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1237938258   35 DVVIMVDSQEFHAHRTVLACTSKMFEILF-----HRNSQHYTLDFLSPKTFQQILEYAYTATLQAKAEDLDDLLYAA 106
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFssdfkESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELA 77

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....
gi 1237938258 561 LKSHKRIHTGEKPYECNGCGKKFS 584
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25

zinc finger;

                           10        20
                   ....*....|....*....|...
gi 1237938258  518 YICSECNRTFPSHTALKRHLRSH 540
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938258  16 HPTGLLCKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRNSQHYTLDFLSPKTFQQILEYAYTATLQAK 95
Cdd:cd18205     1 HPTGLLHKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRNSQHYTLDFLSPKTFQQILEYAYTATLQAK 80

                          90       100
                  ....*....|....*....|....*..
gi 1237938258  96 AEDLDDLLYAAEILEIEYLEEQCLKML 122
Cdd:cd18205    81 VEDLDDLLYAAEILEIEYLEEQCLKIL 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938258  14 PSHPTGLLCKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRNS---QH--YTLDFLSPKTFQQILEYAY 88
Cdd:cd18328     6 PNHSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGTladQPyvYEIDFVTPEALSAILEFAY 85

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1237938258  89 TATLQAKAEDLDDLLYAAEILEIEYLEEQCLKMLE 123
Cdd:cd18328    86 TSTLTITTSNVKHILNAAQMLEIQCIINVCLEIMD 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1237938258  33 LCDVVIMVDSQEFHAHRTVLACTSKMFEILF-----HRNSQHYTLDFLSPKTFQQILEYAYTATLQAKAEDLDDLLYAA 106
Cdd:cd18186     1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFssgmkESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAA 79

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938258  16 HPTGLLCKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMF--EILFHRNSQHYTLDFLSPKTFQQILEYAYTATLQ 93
Cdd:cd18218     1 HSDRLLHLAARLRPAGALCDTLITVGSQEFPAHSLVLAGASQQLgrQLTNPNPGQWCLGEGISPSTFKQLLDFVYGESVE 80

                          90       100
                  ....*....|....*....|....*....
gi 1237938258  94 AKAEDLDDLLYAAEILEIEYLEEQCLKML 122
Cdd:cd18218    81 VQPGELRPLLEAARALEVESLEEACWRAL 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938258   9 IQLQNPSHPTGLLCKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRNS----QHYTLDFLSPKTFQQIL 84
Cdd:cd18224     2 IKLHSSDHPNNLLKELNKCRLSETMCDVTIVVGNRSFAAHKAVLACAAGYFQKLFLSTEldvaRTYVVDFITPANFEKVL 81

                  ....*...
gi 1237938258  85 EYAYTATL 92
Cdd:cd18224    82 SFIYTSEL 89

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938258  14 PSHPTGLLCKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFE-ILFHRNSQHYTLDFLSPKTFQQILEYAYTATL 92
Cdd:cd18334     2 PNHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKsLVLHDNLINLDTDMVNPTVFRQILDFIYTGKL 81

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1237938258  93 ----QAKAEDLDDLLYAAEILEIEYLEEQCLKMLE 123
Cdd:cd18334    82 ltsdQPGEQNFNALLTAASYLQLHDLAALCRKKLK 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938258  25 NQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILF-----HRNSQHYTLDFLSPKTFQQILEYAYTATLQAKAEDL 99
Cdd:cd18240     9 NELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFtngwnETEKKVYKIPGVSPEMMELIIEYAYTRTVPITAENV 88

                  ....*..
gi 1237938258 100 DDLLYAA 106
Cdd:cd18240    89 EELLPAA 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938258  14 PSHPTGLLCKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEIL-FHRNSQHYTLDFLSPKTFQQILEYAYTATL 92
Cdd:cd18216     1 PSHATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSLvLHDNLIHLDQDMVSPTVFQQILDFIYTGKL 80

                          90
                  ....*....|....*..
gi 1237938258  93 QAKAE---DLDDLLYAA 106
Cdd:cd18216    81 LDSLFeepNLSEVLAAA 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938258  15 SHPTGLLCKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILF-----HRNSQHYTLDFLSPKTFQQILEYAYT 89
Cdd:cd18242     3 SHAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFtsemsEKGKSEVELQGLTASTMEILLDFVYT 82

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1237938258  90 ATLQAKAEDLDDLLYAAEILEIEYLEEQCLKMLET 124
Cdd:cd18242    83 ETVHVTVENVQELLPAACLLQLKGVKQACCEFLES 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938258   8 MIQLQNPSHPTGLLCKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRNSQH-YTL-DFLSPKTFQQILE 85
Cdd:cd18289     4 MLHIEIPNFGNTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSaFELpATVPPACFQQILS 83

                          90       100
                  ....*....|....*....|.
gi 1237938258  86 YAYTATLQAKAEDLDDLLYAA 106
Cdd:cd18289    84 FCYTGKLTMAASEQLVVMYTA 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938258  14 PSHPTGLLCKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRNSQHYTLDFLSPKTFQQILEYAYTATLQ 93
Cdd:cd18206     3 PQHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFVDQKDVVHLDISNAAGLGQVLEFMYTAKLS 82

                          90
                  ....*....|...
gi 1237938258  94 AKAEDLDDLLYAA 106
Cdd:cd18206    83 LSPENVDDVLAVA 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938258  16 HPTGLLCKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHR----NSQHYTLDFLSPKTFQQILEYAYTAT 91
Cdd:cd18204     1 HKTVFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKlevdSSSVIEIDFLRSDIFEEVLNYMYTAK 80

                          90
                  ....*....|..
gi 1237938258  92 LQAKAEDLDDLL 103
Cdd:cd18204    81 ISVKKEDVNLMM 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938258  16 HPTGLLCKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRN---SQHYTLDF--LSPKTFQQILEYAYTA 90
Cdd:cd18237     4 LLADFMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNmteSKSSEVELkdAEPDIIELLVEFAYTA 83

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1237938258  91 TLQAKAEDLDDLLYAAEILEIEYLEEQCLKMLET 124
Cdd:cd18237    84 RISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKE 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938258  16 HPTGLLCKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILF-----HRNSQHYTLDFLSPKTFQQILEYAYTA 90
Cdd:cd18255     1 HSVTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFtggmrESSQDEIELKGVSAKGLKHILDFAYTS 80

                          90
                  ....*....|....*.
gi 1237938258  91 TLQAKAEDLDDLLYAA 106
Cdd:cd18255    81 ELTLDLDCIQDVLGAA 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938258  16 HPTGLLCKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHR-----NSQHYTLDFLSPKTFQQILEYAYTA 90
Cdd:cd18223     1 HSDTVLSCLNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYFKNAFSSqeiwiSSHVLELPDLKAEVFAEILNFIYSS 80

                          90
                  ....*....|....*.
gi 1237938258  91 TLQAK-AEDLDDLLYA 105
Cdd:cd18223    81 KVVVKrQETVTDLVAA 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938258  11 LQNPSHPTGLLCKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILF-----HRNSQHYTLDFLSPKTFQQILE 85
Cdd:cd18324     1 MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYkdqldKRDIVHLNSDIVTAPAFALLLE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1237938258  86 YAYTATLQAKAEDLDDLLYAAEILEIEYLEEQCLKMLETIQASDDNDTE 134
Cdd:cd18324    81 FMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEKATTEADSTK 129

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938258  14 PSHPTGLLCKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRNSQHYT------------LDFLSPKTFQ 81
Cdd:cd18327     6 PEHSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGGGGSGdlgagggqdvceLDFVGPEALG 85

                          90       100
                  ....*....|....*....|....*
gi 1237938258  82 QILEYAYTATLQAKAEDLDDLLYAA 106
Cdd:cd18327    86 ALLEFAYTATLTISSSNMREVLRAA 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938258  15 SHPTGLLCKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRNSQH------YTLDFLSPKTFQQILEYAY 88
Cdd:cd18329     3 SHQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKEtgqptvATFDVFSPDTFTIILDFVY 82

                          90
                  ....*....|....*...
gi 1237938258  89 TATLQAKAEDLDDLLYAA 106
Cdd:cd18329    83 SGKLSLTSQNVIEVMSAA 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938258  14 PSHPTGLLCKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMF--EILFHRNSQHYTLDFLSPKTFQQILEYAYTAT 91
Cdd:cd18210     2 PEITSSLLESLNQQRMEGKLCDISIHVQGRVFRAHRAVLAASSPYFhdQVLLKNMSSISLPGVMDPGAFESVLASAYTGK 81

                          90
                  ....*....|..
gi 1237938258  92 LQAKAEDLDDLL 103
Cdd:cd18210    82 LTMLADEIVNYL 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938258  25 NQMRL-AGTLCDVVIMVDSQE--FHAHRTVLACTSKMFEILFHRNSQ----HYTLDFLSPKTFQQILEYAYTATLQAKAE 97
Cdd:cd18231     5 NEQRLfQPDLCDVDIVLVRQRstFPAHKGVLAAYSQFFHSLFTQNKQlqrvELSLEALTSQGLQQILNFIYTSKLLVNSC 84

                          90       100
                  ....*....|....*....|....*..
gi 1237938258  98 DLDDLLYAAEILEIEYLEEQCLKMLET 124
Cdd:cd18231    85 NVQDVLNAAAVLQMNDIAASCQELIDS 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938258  12 QNPSHPTGLLCKANQMRL-AGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILF------HRNSQHYTLDFLSPKTFQQIL 84
Cdd:cd18207     5 QVSQHSADMLHNLNQQRKsGGRFCDVLLRVGEESFPAHRAVLAACSEYFESVFsaqegdGGTPRELEMHTISSKVFGDIL 84

                          90       100
                  ....*....|....*....|..
gi 1237938258  85 EYAYTATLQAKAEDLDDLLYAA 106
Cdd:cd18207    85 DFAYTSRIVVRLESFPELMTAA 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938258  15 SHPTGLLCKANQMRLAGTLCDVVIMVDSQ----EFHAHRTVLACTSKMFEILF-----HRNSQHYTLDFLSPKTFQQILE 85
Cdd:cd18248     3 DHTKEAFQIMNELRLSQQLCDVTLKVKYQdpkeEFMAHKVVLASSSPYFKAMFtsglrECGMEVVPIEGVHPCVMSRLIE 82

                  ....*..
gi 1237938258  86 YAYTATL 92
Cdd:cd18248    83 FAYTASI 89

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938258  32 TLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRN--SQHYTLDFLSPKTFQQILEYAYTATLQAKAEDLDDLLYAAeil 109
Cdd:cd18226    21 SFCDLVITVEGKEFSAHKVVVAVGSSYFHACLSKNpnTDAVTLDHVSYSVFQHLLEFLYTSEFFVYENEIPLVLEAA--- 97

                          90       100
                  ....*....|....*....|....
gi 1237938258 110 eieyleeQCLKMLETIQASDDNDT 133
Cdd:cd18226    98 -------KFLDIIDAVKLLTNEAV 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938258  14 PSHPTGLLCKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFH-----RNSQHYTLDFLSPKTFQQILEYAY 88
Cdd:cd18194     4 PEHSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFHLFYRdrldkRDLVRLNSDIVTAPAFGLLLDFMY 83

                          90
                  ....*....|....*...
gi 1237938258  89 TATLQAKAEDLDDLLYAA 106
Cdd:cd18194    84 EGRLALRDLPVEDVLAAA 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938258  16 HPTGLLCKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRNSQHYTL----DFLSPKTFQQILEYAYTAT 91
Cdd:cd18278    14 HCTNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALVGQTENDLVvslpEEVTARGFGPLLQFAYTAK 93