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Conserved domains on  [gi|1234543352|ref|NP_001341655|]
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DNA repair protein complementing XP-C cells isoform 3 [Homo sapiens]

Protein Classification

rad4 family protein( domain architecture ID 11489429)

rad4 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
rad4 TIGR00605
DNA repair protein rad4; All proteins in this family for which functions are known are ...
 1-674 0e+00

DNA repair protein rad4; All proteins in this family for which functions are known are involved in targeting nucleotide excision repair to specific regions of the genome.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


:

Pssm-ID: 273170 [Multi-domain]  Cd Length: 713  Bit Score: 900.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352   1 MKRFNKGVHEDTHKVHLLCLLANGFYRNNICSQPDLHAIGlSIIPARFTRVLPRDVDTYYLSNLVKWFIGTFTVNAELSA 80
Cdd:TIGR00605  45 KKRFKTGLNELPHEVVLMCNLDSTHSDDRVVSVPDSLSVS-EEIPSREEDYDSREFEDVYLSNLVAEFETISVEIKPSSK 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352  81 SEQDNLQTTLERRFAIYSARDDEELVHIFLLILRALQLLTRLVLSLQpIPLKSATAKGKKPSKERLTADPG--GSSETSS 158
Cdd:TIGR00605 124 AESDDDAETLSRNVCSNEARKDRKYIHILYLLCLMVHLFTRNEWSLS-APLKSAKLSNLIPEKVRLLLHPSvrKSEELPS 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352 159 QVLENHTKPKTSKGTKQEETFAKGtCRPSAKGKR--NKGGRKKRSKpssseedegpGDKQEKATQRRPHGRERRVASRVS 236
Cdd:TIGR00605 203 RSLRGLRKPLVEKLKKCMETWQKG-LRKTTKGLLklLNGGRYSRSK----------WEEIEKSSNRKLGGRKYRTLKRGS 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352 237 YKEESGSDEAGSGSDFELSSGEASDPSDEDSEPGPPKQRKAPAPQRTKAGSKSASRTHRGSHRKDPSLPAASSSSSSSKR 316
Cdd:TIGR00605 272 ILENLNVPTRLVFSDFLLSVSKGHNDPEISSEGFVPKLSACNANQRLIMSCESADRTSRFRMKKDPSLPGFSAYSDMDKS 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352 317 GKKMCSDGEKAEKRSIAGIDQWLEVFCEQEEKWVCVDCVH-GVVGQPLTCYKYATKPMTYVVGIDSDGWVRDVTQRYDPV 395
Cdd:TIGR00605 352 PIFTCEEGDKFIDRWITYVDFWVEVFIEQEEKWVCVDAVHsGVVPKGVTCFEPATLMMTYVFAYDRDGYVKDVTRRYCDQ 431

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352 396 WMTVTRKCRVDAEWWAET-LRPYQSPFMDREK----KEDLEFQAKHMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYP-E 469
Cdd:TIGR00605 432 WSTKVRKRRVEKADFGETwFRPIFGALHKRKRtiddIEDQEFLRRHESEGIPKSIQDLKNHPLYVLERHLKKTQALKPgK 511

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352 470 TAAILGYCRGEA-VYSRDCVHTLHSRDTWLKKARVVRLGEVPYKMVKGfsnRARKARLAEPQLREEnDLGLFGYWQTEEY 548
Cdd:TIGR00605 512 KACTLGFVNGKAgVYSRKDVHDLKSAEQWYKKGRVIKLGEQPYKVVKA---RARTVRLPKGEAEEE-DLGLYSYEQTELY 587

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352 549 QPPVAVDGKVPRNEFGNVYLFLPSMMPIGCVQLNLPNLHRVARKLDIDCVQAITGFDFHGGYSHPVTDGYIVCEEFKDVL 628
Cdd:TIGR00605 588 IPPPAVDGIVPKNAYGNIDLFVPSMIPKGAVHLRLPGAIKAAKKLNIDYAPAVTGFDFHRGYSKPVLDGIIVCEEFREAI 667

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*.
gi 1234543352 629 LTAWENEQAVIERKEKEKKEKRALGNWKLLAKGLLIRERLKRRYGP 674
Cdd:TIGR00605 668 ETAWEEIEQIQEEKEQEKHRKRALGNWKTLLKGLRIRERLKETYGK 713
 
Name Accession Description Interval E-value
rad4 TIGR00605
DNA repair protein rad4; All proteins in this family for which functions are known are ...
 1-674 0e+00

DNA repair protein rad4; All proteins in this family for which functions are known are involved in targeting nucleotide excision repair to specific regions of the genome.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273170 [Multi-domain]  Cd Length: 713  Bit Score: 900.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352   1 MKRFNKGVHEDTHKVHLLCLLANGFYRNNICSQPDLHAIGlSIIPARFTRVLPRDVDTYYLSNLVKWFIGTFTVNAELSA 80
Cdd:TIGR00605  45 KKRFKTGLNELPHEVVLMCNLDSTHSDDRVVSVPDSLSVS-EEIPSREEDYDSREFEDVYLSNLVAEFETISVEIKPSSK 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352  81 SEQDNLQTTLERRFAIYSARDDEELVHIFLLILRALQLLTRLVLSLQpIPLKSATAKGKKPSKERLTADPG--GSSETSS 158
Cdd:TIGR00605 124 AESDDDAETLSRNVCSNEARKDRKYIHILYLLCLMVHLFTRNEWSLS-APLKSAKLSNLIPEKVRLLLHPSvrKSEELPS 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352 159 QVLENHTKPKTSKGTKQEETFAKGtCRPSAKGKR--NKGGRKKRSKpssseedegpGDKQEKATQRRPHGRERRVASRVS 236
Cdd:TIGR00605 203 RSLRGLRKPLVEKLKKCMETWQKG-LRKTTKGLLklLNGGRYSRSK----------WEEIEKSSNRKLGGRKYRTLKRGS 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352 237 YKEESGSDEAGSGSDFELSSGEASDPSDEDSEPGPPKQRKAPAPQRTKAGSKSASRTHRGSHRKDPSLPAASSSSSSSKR 316
Cdd:TIGR00605 272 ILENLNVPTRLVFSDFLLSVSKGHNDPEISSEGFVPKLSACNANQRLIMSCESADRTSRFRMKKDPSLPGFSAYSDMDKS 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352 317 GKKMCSDGEKAEKRSIAGIDQWLEVFCEQEEKWVCVDCVH-GVVGQPLTCYKYATKPMTYVVGIDSDGWVRDVTQRYDPV 395
Cdd:TIGR00605 352 PIFTCEEGDKFIDRWITYVDFWVEVFIEQEEKWVCVDAVHsGVVPKGVTCFEPATLMMTYVFAYDRDGYVKDVTRRYCDQ 431

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352 396 WMTVTRKCRVDAEWWAET-LRPYQSPFMDREK----KEDLEFQAKHMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYP-E 469
Cdd:TIGR00605 432 WSTKVRKRRVEKADFGETwFRPIFGALHKRKRtiddIEDQEFLRRHESEGIPKSIQDLKNHPLYVLERHLKKTQALKPgK 511

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352 470 TAAILGYCRGEA-VYSRDCVHTLHSRDTWLKKARVVRLGEVPYKMVKGfsnRARKARLAEPQLREEnDLGLFGYWQTEEY 548
Cdd:TIGR00605 512 KACTLGFVNGKAgVYSRKDVHDLKSAEQWYKKGRVIKLGEQPYKVVKA---RARTVRLPKGEAEEE-DLGLYSYEQTELY 587

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352 549 QPPVAVDGKVPRNEFGNVYLFLPSMMPIGCVQLNLPNLHRVARKLDIDCVQAITGFDFHGGYSHPVTDGYIVCEEFKDVL 628
Cdd:TIGR00605 588 IPPPAVDGIVPKNAYGNIDLFVPSMIPKGAVHLRLPGAIKAAKKLNIDYAPAVTGFDFHRGYSKPVLDGIIVCEEFREAI 667

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*.
gi 1234543352 629 LTAWENEQAVIERKEKEKKEKRALGNWKLLAKGLLIRERLKRRYGP 674
Cdd:TIGR00605 668 ETAWEEIEQIQEEKEQEKHRKRALGNWKTLLKGLRIRERLKETYGK 713
RAD4 COG5535
DNA repair protein RAD4 [DNA replication, recombination, and repair];
322-675 6.87e-52

DNA repair protein RAD4 [DNA replication, recombination, and repair];


Pssm-ID: 227822 [Multi-domain]  Cd Length: 650  Bit Score: 191.60  E-value: 6.87e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352 322 SDGEKAEKRSIAGIDQWLEVFCEQEEKWVCVDCV--HGVVGQPLTCYKYATKP----MTYVVGIDSDGWVRDVTQRY-DP 394
Cdd:COG5535   289 SEGLLEYIDSLEYPGFWGEVVDKFEKKWVFVDPVrlYIVYSELKCKFEPAASIhlniMEYVGAYDACVYVKDVTLRYrDQ 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352 395 VWMTVTRKCRVDA--EWWAETLRPYQSP--FMDREKKEDLEFQAKHMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYP-- 468
Cdd:COG5535   369 SYSFLKRITKHLFsvQYFVRQFPGLGKCkeASDEEAIEDFDDLDERRSEGIPKSVQDLKRHPKFVLESHLKWNQAIKPga 448

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352 469 ETAAIL--GYCRGEAVYSRDCVHTLHSRDTWLKKARVVRLGEVPYKMVKGFSNRARKarLAEPQLREendlgLFGYWQTE 546
Cdd:COG5535   449 KPGFTLtkGKNSVEAVYLRRDVVRLKSAEQWYRMGRVIKPGAQPLKIVKRMRERVRN--LDDKVIRE-----LYSPEQTE 521

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352 547 EYQPPVAVDGKVPRNEFGNVYLFLPSMMPIGCVQLNLPNLHRVARKLDIDCVQAITGFDFHGGYSHPVTDGYIVCEEFKD 626
Cdd:COG5535   522 LYGPPLVVAGIIPKNMYGNIDYYVPSMIPRGCVLIPNRNARDIARLLGIDYADAVTGFDFGRSTVKPVLRGIVVPKKNLE 601

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1234543352 627 VLLTAWENEQAVIERKEKEKKEKRALGNWKLLAKGLLIRERLKRRYGPK 675
Cdd:COG5535   602 AISNFLAEYERIQEEKERSEVRLGGLKRWKILLRKLRIRLRINEEYGLK 650
BHD_3 smart01032
Rad4 beta-hairpin domain 3; This short domain is found in the Rad4 protein. This domain binds ...
 558-632 6.49e-42

Rad4 beta-hairpin domain 3; This short domain is found in the Rad4 protein. This domain binds to DNA.


Pssm-ID: 198100 [Multi-domain]  Cd Length: 75  Bit Score: 146.55  E-value: 6.49e-42
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1234543352  558 VPRNEFGNVYLFLPSMMPIGCVQLNLPNLHRVARKLDIDCVQAITGFDFHGGYSHPVTDGYIVCEEFKDVLLTAW 632
Cdd:smart01032   1 VPRNEYGNIDLFKPSMLPIGCVHLKLPGLIRVAKRLGIDYAPAVTGFDFKRGSAHPVIDGVVVAEEFAEALLAAW 75
BHD_3 pfam10405
Rad4 beta-hairpin domain 3; This short domain is found in the Rad4 protein. This domain binds ...
 558-629 1.69e-33

Rad4 beta-hairpin domain 3; This short domain is found in the Rad4 protein. This domain binds to DNA.


Pssm-ID: 463079 [Multi-domain]  Cd Length: 73  Bit Score: 122.94  E-value: 1.69e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1234543352 558 VPRNEFGNVYLFLPSMMPIGCVQLNLPNLHRVARKLDIDCVQAITGFDFHGGYSHPVTDGYIVCEEFKDVLL 629
Cdd:pfam10405   1 VPKNAYGNIDIFVPSMLPEGCVHIPLPGAARAAKKLGIDYAPAVTGFDFKGRRGKPVIDGIVVAEEDEEALL 72
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 128-323 8.00e-08

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 55.95  E-value: 8.00e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352  128 PIPLKSATAKGKKPSKERLTADPGGSSETSSQVLENHTKPKTSKGTKQEETFAKGTCRPSAKGKRNKGGRKKRSKPSSSE 207
Cdd:PHA03307   212 PISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSP 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352  208 EDEGPgdkqeKATQRRPHGRERRVASRVSyKEESGSDEAGSGSDfeLSSGEASDPSDedSEPGPPKQRkAPAPQRTKAGS 287
Cdd:PHA03307   292 RERSP-----SPSPSSPGSGPAPSSPRAS-SSSSSSRESSSSST--SSSSESSRGAA--VSPGPSPSR-SPSPSRPPPPA 360

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1234543352  288 KSASRTHRGSHRKDPSLPAASSSSSSSKRGKKMCSD 323
Cdd:PHA03307   361 DPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAG 396
 
Name Accession Description Interval E-value
rad4 TIGR00605
DNA repair protein rad4; All proteins in this family for which functions are known are ...
 1-674 0e+00

DNA repair protein rad4; All proteins in this family for which functions are known are involved in targeting nucleotide excision repair to specific regions of the genome.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273170 [Multi-domain]  Cd Length: 713  Bit Score: 900.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352   1 MKRFNKGVHEDTHKVHLLCLLANGFYRNNICSQPDLHAIGlSIIPARFTRVLPRDVDTYYLSNLVKWFIGTFTVNAELSA 80
Cdd:TIGR00605  45 KKRFKTGLNELPHEVVLMCNLDSTHSDDRVVSVPDSLSVS-EEIPSREEDYDSREFEDVYLSNLVAEFETISVEIKPSSK 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352  81 SEQDNLQTTLERRFAIYSARDDEELVHIFLLILRALQLLTRLVLSLQpIPLKSATAKGKKPSKERLTADPG--GSSETSS 158
Cdd:TIGR00605 124 AESDDDAETLSRNVCSNEARKDRKYIHILYLLCLMVHLFTRNEWSLS-APLKSAKLSNLIPEKVRLLLHPSvrKSEELPS 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352 159 QVLENHTKPKTSKGTKQEETFAKGtCRPSAKGKR--NKGGRKKRSKpssseedegpGDKQEKATQRRPHGRERRVASRVS 236
Cdd:TIGR00605 203 RSLRGLRKPLVEKLKKCMETWQKG-LRKTTKGLLklLNGGRYSRSK----------WEEIEKSSNRKLGGRKYRTLKRGS 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352 237 YKEESGSDEAGSGSDFELSSGEASDPSDEDSEPGPPKQRKAPAPQRTKAGSKSASRTHRGSHRKDPSLPAASSSSSSSKR 316
Cdd:TIGR00605 272 ILENLNVPTRLVFSDFLLSVSKGHNDPEISSEGFVPKLSACNANQRLIMSCESADRTSRFRMKKDPSLPGFSAYSDMDKS 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352 317 GKKMCSDGEKAEKRSIAGIDQWLEVFCEQEEKWVCVDCVH-GVVGQPLTCYKYATKPMTYVVGIDSDGWVRDVTQRYDPV 395
Cdd:TIGR00605 352 PIFTCEEGDKFIDRWITYVDFWVEVFIEQEEKWVCVDAVHsGVVPKGVTCFEPATLMMTYVFAYDRDGYVKDVTRRYCDQ 431

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352 396 WMTVTRKCRVDAEWWAET-LRPYQSPFMDREK----KEDLEFQAKHMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYP-E 469
Cdd:TIGR00605 432 WSTKVRKRRVEKADFGETwFRPIFGALHKRKRtiddIEDQEFLRRHESEGIPKSIQDLKNHPLYVLERHLKKTQALKPgK 511

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352 470 TAAILGYCRGEA-VYSRDCVHTLHSRDTWLKKARVVRLGEVPYKMVKGfsnRARKARLAEPQLREEnDLGLFGYWQTEEY 548
Cdd:TIGR00605 512 KACTLGFVNGKAgVYSRKDVHDLKSAEQWYKKGRVIKLGEQPYKVVKA---RARTVRLPKGEAEEE-DLGLYSYEQTELY 587

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352 549 QPPVAVDGKVPRNEFGNVYLFLPSMMPIGCVQLNLPNLHRVARKLDIDCVQAITGFDFHGGYSHPVTDGYIVCEEFKDVL 628
Cdd:TIGR00605 588 IPPPAVDGIVPKNAYGNIDLFVPSMIPKGAVHLRLPGAIKAAKKLNIDYAPAVTGFDFHRGYSKPVLDGIIVCEEFREAI 667

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*.
gi 1234543352 629 LTAWENEQAVIERKEKEKKEKRALGNWKLLAKGLLIRERLKRRYGP 674
Cdd:TIGR00605 668 ETAWEEIEQIQEEKEQEKHRKRALGNWKTLLKGLRIRERLKETYGK 713
RAD4 COG5535
DNA repair protein RAD4 [DNA replication, recombination, and repair];
322-675 6.87e-52

DNA repair protein RAD4 [DNA replication, recombination, and repair];


Pssm-ID: 227822 [Multi-domain]  Cd Length: 650  Bit Score: 191.60  E-value: 6.87e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352 322 SDGEKAEKRSIAGIDQWLEVFCEQEEKWVCVDCV--HGVVGQPLTCYKYATKP----MTYVVGIDSDGWVRDVTQRY-DP 394
Cdd:COG5535   289 SEGLLEYIDSLEYPGFWGEVVDKFEKKWVFVDPVrlYIVYSELKCKFEPAASIhlniMEYVGAYDACVYVKDVTLRYrDQ 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352 395 VWMTVTRKCRVDA--EWWAETLRPYQSP--FMDREKKEDLEFQAKHMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYP-- 468
Cdd:COG5535   369 SYSFLKRITKHLFsvQYFVRQFPGLGKCkeASDEEAIEDFDDLDERRSEGIPKSVQDLKRHPKFVLESHLKWNQAIKPga 448

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352 469 ETAAIL--GYCRGEAVYSRDCVHTLHSRDTWLKKARVVRLGEVPYKMVKGFSNRARKarLAEPQLREendlgLFGYWQTE 546
Cdd:COG5535   449 KPGFTLtkGKNSVEAVYLRRDVVRLKSAEQWYRMGRVIKPGAQPLKIVKRMRERVRN--LDDKVIRE-----LYSPEQTE 521

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352 547 EYQPPVAVDGKVPRNEFGNVYLFLPSMMPIGCVQLNLPNLHRVARKLDIDCVQAITGFDFHGGYSHPVTDGYIVCEEFKD 626
Cdd:COG5535   522 LYGPPLVVAGIIPKNMYGNIDYYVPSMIPRGCVLIPNRNARDIARLLGIDYADAVTGFDFGRSTVKPVLRGIVVPKKNLE 601

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1234543352 627 VLLTAWENEQAVIERKEKEKKEKRALGNWKLLAKGLLIRERLKRRYGPK 675
Cdd:COG5535   602 AISNFLAEYERIQEEKERSEVRLGGLKRWKILLRKLRIRLRINEEYGLK 650
BHD_3 smart01032
Rad4 beta-hairpin domain 3; This short domain is found in the Rad4 protein. This domain binds ...
 558-632 6.49e-42

Rad4 beta-hairpin domain 3; This short domain is found in the Rad4 protein. This domain binds to DNA.


Pssm-ID: 198100 [Multi-domain]  Cd Length: 75  Bit Score: 146.55  E-value: 6.49e-42
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1234543352  558 VPRNEFGNVYLFLPSMMPIGCVQLNLPNLHRVARKLDIDCVQAITGFDFHGGYSHPVTDGYIVCEEFKDVLLTAW 632
Cdd:smart01032   1 VPRNEYGNIDLFKPSMLPIGCVHLKLPGLIRVAKRLGIDYAPAVTGFDFKRGSAHPVIDGVVVAEEFAEALLAAW 75
BHD_3 pfam10405
Rad4 beta-hairpin domain 3; This short domain is found in the Rad4 protein. This domain binds ...
 558-629 1.69e-33

Rad4 beta-hairpin domain 3; This short domain is found in the Rad4 protein. This domain binds to DNA.


Pssm-ID: 463079 [Multi-domain]  Cd Length: 73  Bit Score: 122.94  E-value: 1.69e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1234543352 558 VPRNEFGNVYLFLPSMMPIGCVQLNLPNLHRVARKLDIDCVQAITGFDFHGGYSHPVTDGYIVCEEFKDVLL 629
Cdd:pfam10405   1 VPKNAYGNIDIFVPSMLPEGCVHIPLPGAARAAKKLGIDYAPAVTGFDFKGRRGKPVIDGIVVAEEDEEALL 72
Rad4 pfam03835
Rad4 transglutaminase-like domain;
338-433 3.33e-21

Rad4 transglutaminase-like domain;


Pssm-ID: 427539 [Multi-domain]  Cd Length: 146  Bit Score: 90.54  E-value: 3.33e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352 338 WLEVFCEQEEKWVCVDCVHGVVGQPLTCY--KYATK---PMTYVVGIDSDGWVRDVTQRYDPVWMTVTRKCRVD-----A 407
Cdd:pfam03835  39 WVEVFNPETKKWISVDPLVLKTIELKSKFepRIAEKalnVMTYVVAFDSDGGAKDVTRRYCSTYNAKTRKRRIErtddgK 118

                          90       100
                  ....*....|....*....|....*...
gi 1234543352 408 EWWAETLRPYQSPFMDR--EKKEDLEFQ 433
Cdd:pfam03835 119 DWWESVLRPYNKPNREAsrDDYEDAELL 146
BHD_2 smart01031
Rad4 beta-hairpin domain 2; This short domain is found in the Rad4 protein. This domain binds ...
 491-550 1.42e-19

Rad4 beta-hairpin domain 2; This short domain is found in the Rad4 protein. This domain binds to DNA.


Pssm-ID: 214985 [Multi-domain]  Cd Length: 56  Bit Score: 82.73  E-value: 1.42e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352  491 LHSRDTWLKKARVVRLGEVPYKMVKgfsnRARKARLAEPQLREENDLGLFGYWQTEEYQP 550
Cdd:smart01031   1 LKSAEHWLRQGRVVKPGEQPYKVVK----RKRKKDRIPNDTGEEEELELYGEWQTELYIP 56
BHD_1 smart01030
Rad4 beta-hairpin domain 1; This short domain is found in the Rad4 protein. This domain binds ...
 437-488 2.15e-18

Rad4 beta-hairpin domain 1; This short domain is found in the Rad4 protein. This domain binds to DNA.


Pssm-ID: 214984 [Multi-domain]  Cd Length: 54  Bit Score: 79.19  E-value: 2.15e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1234543352  437 MDQPLPTAIGLYKNHPLYALKRHLLKYEAIYPETAAI--LGYCRGEAVYSRDCV 488
Cdd:smart01030   1 LNEPIPTSIQDFKNHPLYVLERHLKKNEAIYPKAKPVgtFGYGKGEPVYLRSDV 54
BHD_2 pfam10404
Rad4 beta-hairpin domain 2; This short domain is found in the Rad4 protein. This domain binds ...
 492-551 7.99e-16

Rad4 beta-hairpin domain 2; This short domain is found in the Rad4 protein. This domain binds to DNA.


Pssm-ID: 463078 [Multi-domain]  Cd Length: 63  Bit Score: 72.25  E-value: 7.99e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1234543352 492 HSRDTWLKKARVVRLGEVPYKMVKGFSNRARKARLAEPQL---REENDLGLFGYWQTEEYQPP 551
Cdd:pfam10404   1 KSAEKWYREGREVKPGEQPLKRVKARAVTKNRKREEEDAReedGEEGGVGLYAEWQTELYIPP 63
BHD_1 pfam10403
Rad4 beta-hairpin domain 1; This short domain is found in the Rad4 protein. This domain binds ...
 440-488 9.08e-15

Rad4 beta-hairpin domain 1; This short domain is found in the Rad4 protein. This domain binds to DNA.


Pssm-ID: 463077  Cd Length: 54  Bit Score: 69.11  E-value: 9.08e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1234543352 440 PLPTAIGLYKNHPLYALKRHLLKYEAIYPeTAAILGYCR----GEAVYSRDCV 488
Cdd:pfam10403   3 PMPTNIQDFKNHPLYVLERHLKRNEVIYP-GAKPVGTFRykkkGEPVYRRSDV 54
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 128-323 8.00e-08

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 55.95  E-value: 8.00e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352  128 PIPLKSATAKGKKPSKERLTADPGGSSETSSQVLENHTKPKTSKGTKQEETFAKGTCRPSAKGKRNKGGRKKRSKPSSSE 207
Cdd:PHA03307   212 PISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSP 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352  208 EDEGPgdkqeKATQRRPHGRERRVASRVSyKEESGSDEAGSGSDfeLSSGEASDPSDedSEPGPPKQRkAPAPQRTKAGS 287
Cdd:PHA03307   292 RERSP-----SPSPSSPGSGPAPSSPRAS-SSSSSSRESSSSST--SSSSESSRGAA--VSPGPSPSR-SPSPSRPPPPA 360

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1234543352  288 KSASRTHRGSHRKDPSLPAASSSSSSSKRGKKMCSD 323
Cdd:PHA03307   361 DPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAG 396
recX PRK14136
recombination regulator RecX; Provisional
 162-306 6.31e-04

recombination regulator RecX; Provisional


Pssm-ID: 237620 [Multi-domain]  Cd Length: 309  Bit Score: 42.68  E-value: 6.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543352 162 ENHTKPKTSkGTKQEETFAKGTCRPSAKGKRNKGGRKKRSKPSS--SEEDEGPGDKQEKATQRRPHGRERRVASRVSYKE 239
Cdd:PRK14136   11 QEADHPARA-ARAGRPHASRETDRTVSGEGRPAGRTATRASDDAlvSFEIAAPDEPFDDDESFDAHDRARRRVSGVGVRD 89

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1234543352 240 E-SGSDEAGSGSDFELSSGEASDPSDED----SEPGPPKQRKAPAPQRTKAGSKSASRTHRGSHRKDPSLPA 306
Cdd:PRK14136   90 AgAPGGRAADARAANLSSAAKRAEAAGDvytrTSQHPRRTRRAAGPFHSDSSPSASSEDDGAARSRASSRPA 161
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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