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Conserved domains on  [gi|1231293801|ref|NP_001341502|]
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alpha-2-HS-glycoprotein isoform 4 preproprotein [Homo sapiens]

Protein Classification

cystatin family protein( domain architecture ID 11249389)

cystatin family protein similar to cystatins which are a family of cysteine protease inhibitors

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 31-133 5.72e-11

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


:

Pssm-ID: 214484  Cd Length: 107  Bit Score: 58.59  E-value: 5.72e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231293801   31 NCDDPETEEAALVAIDYINQNLpwGYKHTLNQIDEVKVWPQQPSGELFEIEIDTLETTCHVLDPTPvARCSVRQLKehav 110
Cdd:smart00043  10 PPNDPEVQEAADFAVAEYNKKS--NDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSVDL-ENCPFLDQG---- 82

                           90       100
                   ....*....|....*....|....*
gi 1231293801  111 EGDCDFQLLKLDG--KFSVVYAKCD 133
Cdd:smart00043  83 EKFCTAKVWEKPWenKIKLVEFKCT 107
CY super family cl09238
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 149-226 1.10e-04

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


The actual alignment was detected with superfamily member pfam00031:

Pssm-ID: 447698  Cd Length: 92  Bit Score: 40.40  E-value: 1.10e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1231293801 149 CPLLAPLNDTRVVHAAKAALAAFNAQNNGSNFQLEEISRAQLVPLPPSTY-VEFTVSGTDCVaKEATEAAKCNLLAEKP 226
Cdd:pfam00031   2 GLSPIPDNSPELQEALDFALAEYNAKTDNYYFELVEVKRAKSQVVAGTNYfIKVEVGETDCS-KSKKLLEDCPLLDEKW 79
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 31-133 5.72e-11

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 58.59  E-value: 5.72e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231293801   31 NCDDPETEEAALVAIDYINQNLpwGYKHTLNQIDEVKVWPQQPSGELFEIEIDTLETTCHVLDPTPvARCSVRQLKehav 110
Cdd:smart00043  10 PPNDPEVQEAADFAVAEYNKKS--NDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSVDL-ENCPFLDQG---- 82

                           90       100
                   ....*....|....*....|....*
gi 1231293801  111 EGDCDFQLLKLDG--KFSVVYAKCD 133
Cdd:smart00043  83 EKFCTAKVWEKPWenKIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 28-120 2.12e-07

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 48.62  E-value: 2.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231293801  28 RQPNCDDPETEEAALVAIDYINQNLpwgyKHTLNQIDEV-KVWPQQPSGELFEIEIDTLETTCHVLDPTPVarCSVRQLK 106
Cdd:cd00042     4 SDIPANDPEVQELADFAVAEYNKKS----NDKYLEFFKVlSAKSQVVAGTNYYITVEAGDTNCKKSSVPLD--CPDCKLL 77

                          90
                  ....*....|....
gi 1231293801 107 EHAVEGDCDFQLLK 120
Cdd:cd00042    78 EEGKKKFCTAKVWE 91
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 149-226 1.10e-04

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 40.40  E-value: 1.10e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1231293801 149 CPLLAPLNDTRVVHAAKAALAAFNAQNNGSNFQLEEISRAQLVPLPPSTY-VEFTVSGTDCVaKEATEAAKCNLLAEKP 226
Cdd:pfam00031   2 GLSPIPDNSPELQEALDFALAEYNAKTDNYYFELVEVKRAKSQVVAGTNYfIKVEVGETDCS-KSKKLLEDCPLLDEKW 79
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 146-226 5.43e-04

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 38.95  E-value: 5.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231293801  146 CQDCPLLAPLNDTRVVHAAKAALAAFnaqNNGSN--FQLEEISRA---QLVPLPPSTYVEFTVSGTDCVaKEATEAAKCN 220
Cdd:smart00043   2 CLGGPSDVPPNDPEVQEAADFAVAEY---NKKSNdkYELRVIKVVsakSQVVAGTNYYLKVEVGETNCK-KLSVDLENCP 77


                   ....*.
gi 1231293801  221 LLAEKP 226
Cdd:smart00043  78 FLDQGE 83
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 31-133 5.72e-11

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 58.59  E-value: 5.72e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231293801   31 NCDDPETEEAALVAIDYINQNLpwGYKHTLNQIDEVKVWPQQPSGELFEIEIDTLETTCHVLDPTPvARCSVRQLKehav 110
Cdd:smart00043  10 PPNDPEVQEAADFAVAEYNKKS--NDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSVDL-ENCPFLDQG---- 82

                           90       100
                   ....*....|....*....|....*
gi 1231293801  111 EGDCDFQLLKLDG--KFSVVYAKCD 133
Cdd:smart00043  83 EKFCTAKVWEKPWenKIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 28-120 2.12e-07

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 48.62  E-value: 2.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231293801  28 RQPNCDDPETEEAALVAIDYINQNLpwgyKHTLNQIDEV-KVWPQQPSGELFEIEIDTLETTCHVLDPTPVarCSVRQLK 106
Cdd:cd00042     4 SDIPANDPEVQELADFAVAEYNKKS----NDKYLEFFKVlSAKSQVVAGTNYYITVEAGDTNCKKSSVPLD--CPDCKLL 77

                          90
                  ....*....|....
gi 1231293801 107 EHAVEGDCDFQLLK 120
Cdd:cd00042    78 EEGKKKFCTAKVWE 91
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 149-226 1.10e-04

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 40.40  E-value: 1.10e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1231293801 149 CPLLAPLNDTRVVHAAKAALAAFNAQNNGSNFQLEEISRAQLVPLPPSTY-VEFTVSGTDCVaKEATEAAKCNLLAEKP 226
Cdd:pfam00031   2 GLSPIPDNSPELQEALDFALAEYNAKTDNYYFELVEVKRAKSQVVAGTNYfIKVEVGETDCS-KSKKLLEDCPLLDEKW 79
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 146-226 5.43e-04

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 38.95  E-value: 5.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231293801  146 CQDCPLLAPLNDTRVVHAAKAALAAFnaqNNGSN--FQLEEISRA---QLVPLPPSTYVEFTVSGTDCVaKEATEAAKCN 220
Cdd:smart00043   2 CLGGPSDVPPNDPEVQEAADFAVAEY---NKKSNdkYELRVIKVVsakSQVVAGTNYYLKVEVGETNCK-KLSVDLENCP 77


                   ....*.
gi 1231293801  221 LLAEKP 226
Cdd:smart00043  78 FLDQGE 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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