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Conserved domains on  [gi|1217323918|ref|NP_001340566|]
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NEDD4-binding protein 2-like 1 isoform 15 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4639 super family cl44097
Predicted kinase [General function prediction only];
41-86 8.58e-09

Predicted kinase [General function prediction only];


The actual alignment was detected with superfamily member COG4639:

Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 49.44  E-value: 8.58e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1217323918  41 RKHLYLLRGLPGSGKTTLARddwsEHWPGSLkIVPSDLLRHLLAGD 86
Cdd:COG4639     1 MLSLVVLIGLPGSGKSTFAR----RLFAPTE-VVSSDDIRALLGGD 41
 
Name Accession Description Interval E-value
COG4639 COG4639
Predicted kinase [General function prediction only];
41-86 8.58e-09

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 49.44  E-value: 8.58e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1217323918  41 RKHLYLLRGLPGSGKTTLARddwsEHWPGSLkIVPSDLLRHLLAGD 86
Cdd:COG4639     1 MLSLVVLIGLPGSGKSTFAR----RLFAPTE-VVSSDDIRALLGGD 41
KaiC-like_N cd19488
N-terminal domain of KaiC family protein; uncharacterized subfamily; KaiC is a circadian clock ...
 41-59 4.85e-04

N-terminal domain of KaiC family protein; uncharacterized subfamily; KaiC is a circadian clock protein, most studied in cyanobacteria. KaiC, an autokinase, autophosphatase, and ATPase, is part of the core oscillator, composed of three proteins: KaiA, KaiB, and KaiC. The circadian oscillation is regulated via KaiC phosphorylation.


Pssm-ID: 410896 [Multi-domain]  Cd Length: 225  Bit Score: 37.33  E-value: 4.85e-04
                          10
                  ....*....|....*....
gi 1217323918  41 RKHLYLLRGLPGSGKTTLA 59
Cdd:cd19488    18 PRRLYLVEGAPGTGKTTLA 36
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 44-94 9.04e-04

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 36.13  E-value: 9.04e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1217323918  44 LYLLRGLPGSGKTTlarddWSEHWPGSLK--IVPSDLLRHLLAGDFGQSSSFS 94
Cdd:pfam13671   1 LILLVGLPGSGKST-----LARRLLEELGavRLSSDDERKRLFGEGRPSISYY 48
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 41-60 8.33e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 33.50  E-value: 8.33e-03
                           10        20
                   ....*....|....*....|
gi 1217323918   41 RKHLYLLRGLPGSGKTTLAR 60
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLAR 20
 
Name Accession Description Interval E-value
COG4639 COG4639
Predicted kinase [General function prediction only];
41-86 8.58e-09

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 49.44  E-value: 8.58e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1217323918  41 RKHLYLLRGLPGSGKTTLARddwsEHWPGSLkIVPSDLLRHLLAGD 86
Cdd:COG4639     1 MLSLVVLIGLPGSGKSTFAR----RLFAPTE-VVSSDDIRALLGGD 41
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
44-60 9.11e-05

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 39.13  E-value: 9.11e-05
                          10
                  ....*....|....*..
gi 1217323918  44 LYLLRGLPGSGKTTLAR 60
Cdd:COG0645     1 LILVCGLPGSGKSTLAR 17
Kti12 COG4088
tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) ...
 44-87 1.36e-04

tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 443264 [Multi-domain]  Cd Length: 179  Bit Score: 38.55  E-value: 1.36e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1217323918  44 LYLLRGLPGSGKTTLARDDWSEHW-PGSLKIV-PSDLLRHLLAGDF 87
Cdd:COG4088     6 LLILTGPPGSGKTTFAKALAQRLYaEGIAVALlHSDDFRRFLVNES 51
KaiC-like_N cd19488
N-terminal domain of KaiC family protein; uncharacterized subfamily; KaiC is a circadian clock ...
 41-59 4.85e-04

N-terminal domain of KaiC family protein; uncharacterized subfamily; KaiC is a circadian clock protein, most studied in cyanobacteria. KaiC, an autokinase, autophosphatase, and ATPase, is part of the core oscillator, composed of three proteins: KaiA, KaiB, and KaiC. The circadian oscillation is regulated via KaiC phosphorylation.


Pssm-ID: 410896 [Multi-domain]  Cd Length: 225  Bit Score: 37.33  E-value: 4.85e-04
                          10
                  ....*....|....*....
gi 1217323918  41 RKHLYLLRGLPGSGKTTLA 59
Cdd:cd19488    18 PRRLYLVEGAPGTGKTTLA 36
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 44-94 9.04e-04

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 36.13  E-value: 9.04e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1217323918  44 LYLLRGLPGSGKTTlarddWSEHWPGSLK--IVPSDLLRHLLAGDFGQSSSFS 94
Cdd:pfam13671   1 LILLVGLPGSGKST-----LARRLLEELGavRLSSDDERKRLFGEGRPSISYY 48
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 41-79 1.66e-03

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 35.91  E-value: 1.66e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1217323918  41 RKHLyLLRGLPGSGKTTLARdDWSEHWPGSLKIV-------PSDLL 79
Cdd:COG0714    31 GGHL-LLEGVPGVGKTTLAK-ALARALGLPFIRIqftpdllPSDIL 74
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 41-60 8.33e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 33.50  E-value: 8.33e-03
                           10        20
                   ....*....|....*....|
gi 1217323918   41 RKHLYLLRGLPGSGKTTLAR 60
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLAR 20
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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