NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1217324609|ref|NP_001340564|]
View 

NEDD4-binding protein 2-like 1 isoform 13 [Homo sapiens]

Protein Classification

nucleoside/nucleotide kinase family protein( domain architecture ID 106737)

nucleoside/nucleotide kinase family protein may catalyze the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG4639 super family cl44097
Predicted kinase [General function prediction only];
41-77 2.79e-08

Predicted kinase [General function prediction only];


The actual alignment was detected with superfamily member COG4639:

Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 49.44  E-value: 2.79e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1217324609  41 RKHLYLLRGLPGSGKTTLARQLqhdFPRALIFSTDDF 77
Cdd:COG4639     1 MLSLVVLIGLPGSGKSTFARRL---FAPTEVVSSDDI 34
 
Name Accession Description Interval E-value
COG4639 COG4639
Predicted kinase [General function prediction only];
41-77 2.79e-08

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 49.44  E-value: 2.79e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1217324609  41 RKHLYLLRGLPGSGKTTLARQLqhdFPRALIFSTDDF 77
Cdd:COG4639     1 MLSLVVLIGLPGSGKSTFARRL---FAPTEVVSSDDI 34
NRK1 cd02024
Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide ...
 47-82 2.92e-05

Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR salvage pathway of NAD+ biosynthesis in addition to the pathways through nicotinic acid mononucleotide (NaMN). This enzyme can also phosphorylate the anticancer drug tiazofurin, which is an analog of nicotinamide riboside.


Pssm-ID: 238982 [Multi-domain]  Cd Length: 187  Bit Score: 41.54  E-value: 2.92e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1217324609  47 LRGLPGSGKTTLARQLQHDFPRALIFSTDDFFFRED 82
Cdd:cd02024     4 ISGVTNSGKTTLAKLLQRILPNCCVIHQDDFFKPED 39
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 44-102 7.02e-05

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 39.99  E-value: 7.02e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1217324609  44 LYLLRGLPGSGKTTLARQLqHDFPRALIFSTDDFFFR----EDGAYEFNPDFLEEAHEWNQKR 102
Cdd:pfam13671   1 LILLVGLPGSGKSTLARRL-LEELGAVRLSSDDERKRlfgeGRPSISYYTDATDRTYERLHEL 62
PRK06762 PRK06762
hypothetical protein; Provisional
 44-71 7.21e-04

hypothetical protein; Provisional


Pssm-ID: 235858  Cd Length: 166  Bit Score: 37.64  E-value: 7.21e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 1217324609  44 LYLLRGLPGSGKTTLARQLQHDFPR--ALI 71
Cdd:PRK06762    4 LIIIRGNSGSGKTTIAKQLQERLGRgtLLV 33
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 41-78 2.07e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 36.20  E-value: 2.07e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1217324609   41 RKHLYLLRGLPGSGKTTL----ARQLQHDFPRALIFSTDDFF 78
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLaralARELGPPGGGVIYIDGEDIL 42
 
Name Accession Description Interval E-value
COG4639 COG4639
Predicted kinase [General function prediction only];
41-77 2.79e-08

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 49.44  E-value: 2.79e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1217324609  41 RKHLYLLRGLPGSGKTTLARQLqhdFPRALIFSTDDF 77
Cdd:COG4639     1 MLSLVVLIGLPGSGKSTFARRL---FAPTEVVSSDDI 34
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
44-76 1.35e-06

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 44.90  E-value: 1.35e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1217324609  44 LYLLRGLPGSGKTTLARQLQHDFPrALIFSTDD 76
Cdd:COG0645     1 LILVCGLPGSGKSTLARALAERLG-AVRLRSDV 32
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 49-98 1.94e-05

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 42.13  E-value: 1.94e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1217324609  49 GLPGSGKTTLARQLQHDFP--RALIFSTDDFFF-REDGAYE--FNPDFLE-EAHEW 98
Cdd:COG0572    14 GPSGSGKTTFARRLAEQLGadKVVVISLDDYYKdREHLPLDerGKPNFDHpEAFDL 69
NRK1 cd02024
Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide ...
 47-82 2.92e-05

Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR salvage pathway of NAD+ biosynthesis in addition to the pathways through nicotinic acid mononucleotide (NaMN). This enzyme can also phosphorylate the anticancer drug tiazofurin, which is an analog of nicotinamide riboside.


Pssm-ID: 238982 [Multi-domain]  Cd Length: 187  Bit Score: 41.54  E-value: 2.92e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1217324609  47 LRGLPGSGKTTLARQLQHDFPRALIFSTDDFFFRED 82
Cdd:cd02024     4 ISGVTNSGKTTLAKLLQRILPNCCVIHQDDFFKPED 39
Kti12 COG4088
tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) ...
 44-97 3.24e-05

tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 443264 [Multi-domain]  Cd Length: 179  Bit Score: 41.64  E-value: 3.24e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1217324609  44 LYLLRGLPGSGKTTLARQLQHDFPR----ALIFSTDDffFREDGAYEFNPDfleEAHE 97
Cdd:COG4088     6 LLILTGPPGSGKTTFAKALAQRLYAegiaVALLHSDD--FRRFLVNESFPK---ETYE 58
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 44-102 7.02e-05

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 39.99  E-value: 7.02e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1217324609  44 LYLLRGLPGSGKTTLARQLqHDFPRALIFSTDDFFFR----EDGAYEFNPDFLEEAHEWNQKR 102
Cdd:pfam13671   1 LILLVGLPGSGKSTLARRL-LEELGAVRLSSDDERKRlfgeGRPSISYYTDATDRTYERLHEL 62
KaiC-like_N cd19488
N-terminal domain of KaiC family protein; uncharacterized subfamily; KaiC is a circadian clock ...
 41-61 3.34e-04

N-terminal domain of KaiC family protein; uncharacterized subfamily; KaiC is a circadian clock protein, most studied in cyanobacteria. KaiC, an autokinase, autophosphatase, and ATPase, is part of the core oscillator, composed of three proteins: KaiA, KaiB, and KaiC. The circadian oscillation is regulated via KaiC phosphorylation.


Pssm-ID: 410896 [Multi-domain]  Cd Length: 225  Bit Score: 38.87  E-value: 3.34e-04
                          10        20
                  ....*....|....*....|.
gi 1217324609  41 RKHLYLLRGLPGSGKTTLARQ 61
Cdd:cd19488    18 PRRLYLVEGAPGTGKTTLALQ 38
PRK06762 PRK06762
hypothetical protein; Provisional
 44-71 7.21e-04

hypothetical protein; Provisional


Pssm-ID: 235858  Cd Length: 166  Bit Score: 37.64  E-value: 7.21e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 1217324609  44 LYLLRGLPGSGKTTLARQLQHDFPR--ALI 71
Cdd:PRK06762    4 LIIIRGNSGSGKTTIAKQLQERLGRgtLLV 33
pseT PHA02530
polynucleotide kinase; Provisional
 42-88 1.06e-03

polynucleotide kinase; Provisional


Pssm-ID: 222856 [Multi-domain]  Cd Length: 300  Bit Score: 37.69  E-value: 1.06e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1217324609  42 KHLYLLRGLPGSGKTTLARQLQHDFPRALIFSTDDFFF-----REDGAYEFN 88
Cdd:PHA02530    2 MKIILTVGVPGSGKSTWAREFAAKNPKAVNVNRDDLRQslfghGEWGEYKFT 53
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 41-62 1.42e-03

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 37.07  E-value: 1.42e-03
                          10        20
                  ....*....|....*....|..
gi 1217324609  41 RKHLyLLRGLPGSGKTTLARQL 62
Cdd:COG0714    31 GGHL-LLEGVPGVGKTTLAKAL 51
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 41-78 2.07e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 36.20  E-value: 2.07e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1217324609   41 RKHLYLLRGLPGSGKTTL----ARQLQHDFPRALIFSTDDFF 78
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLaralARELGPPGGGVIYIDGEDIL 42
Zeta_toxin pfam06414
Zeta toxin; This family consists of several bacterial zeta toxin proteins. Zeta toxin is ...
 41-93 2.33e-03

Zeta toxin; This family consists of several bacterial zeta toxin proteins. Zeta toxin is thought to be part of a postregulational killing system in bacteria. It relies on antitoxin/toxin systems that secure stable inheritance of low and medium copy number plasmids during cell division and kill cells that have lost the plasmid.


Pssm-ID: 428926  Cd Length: 192  Bit Score: 36.19  E-value: 2.33e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1217324609  41 RKHLYLLRGLPGSGKTTLARQLQHDFPR---ALIFSTDDffFRedgayEFNPDFLE 93
Cdd:pfam06414  10 RPKAILLGGQPGAGKTELARALLDELGRqgnVVRIDPDD--FR-----ELHPHYRE 58
PRK08233 PRK08233
hypothetical protein; Provisional
 49-79 3.08e-03

hypothetical protein; Provisional


Pssm-ID: 181310 [Multi-domain]  Cd Length: 182  Bit Score: 35.87  E-value: 3.08e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1217324609  49 GLPGSGKTTLARQLQHDFPRALIFSTDDFFF 79
Cdd:PRK08233   10 AVSGGGKTTLTERLTHKLKNSKALYFDRYDF 40
AAA_24 pfam13479
AAA domain; This AAA domain is found in a wide variety of presumed phage proteins.
 45-76 8.88e-03

AAA domain; This AAA domain is found in a wide variety of presumed phage proteins.


Pssm-ID: 433243  Cd Length: 199  Bit Score: 34.61  E-value: 8.88e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1217324609  45 YLLRGLPGSGKTTLARQlqhdFPRALIFSTDD 76
Cdd:pfam13479   5 ILIYGPSGIGKTTFAKT----LPKPLFLDTEK 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH