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Conserved domains on  [gi|1217320108|ref|NP_001340556|]
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NEDD4-binding protein 2-like 1 isoform 5 [Homo sapiens]

Protein Classification

ATP-binding protein( domain architecture ID 1004283)

ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AAA_33 super family cl38431
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 165-269 3.52e-10

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


The actual alignment was detected with superfamily member pfam13671:

Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 57.32  E-value: 3.52e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1217320108 165 STDDFFFR----EDGAYEFNPDFLEEAHEWNQKRARKAMRNGIsPIIIDNTNLHAWEMKPYAVMALENNYE---VIFREP 237
Cdd:pfam13671  29 SSDDERKRlfgeGRPSISYYTDATDRTYERLHELARIALRAGR-PVILDATNLRRDERARLLALAREYGVPvriVVFEAP 107

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1217320108 238 DTRWKFNVQELARRNIHG--VSREKIHRMKERYE 269
Cdd:pfam13671 108 EEVLRERLAARARAGGDPsdVPEEVLDRQKARFE 141
COG0645 super family cl33991
Predicted kinase, contains AAA domain [General function prediction only];
44-60 1.25e-03

Predicted kinase, contains AAA domain [General function prediction only];


The actual alignment was detected with superfamily member COG0645:

Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 39.13  E-value: 1.25e-03
                          10
                  ....*....|....*..
gi 1217320108  44 LYLLRGLPGSGKTTLAR 60
Cdd:COG0645     1 LILVCGLPGSGKSTLAR 17
 
Name Accession Description Interval E-value
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 165-269 3.52e-10

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 57.32  E-value: 3.52e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1217320108 165 STDDFFFR----EDGAYEFNPDFLEEAHEWNQKRARKAMRNGIsPIIIDNTNLHAWEMKPYAVMALENNYE---VIFREP 237
Cdd:pfam13671  29 SSDDERKRlfgeGRPSISYYTDATDRTYERLHELARIALRAGR-PVILDATNLRRDERARLLALAREYGVPvriVVFEAP 107

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1217320108 238 DTRWKFNVQELARRNIHG--VSREKIHRMKERYE 269
Cdd:pfam13671 108 EEVLRERLAARARAGGDPsdVPEEVLDRQKARFE 141
COG4639 COG4639
Predicted kinase [General function prediction only];
158-270 4.23e-06

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 45.98  E-value: 4.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1217320108 158 FPRALIFSTDDF---FFREDGAYEFNPDFLEEAHEwnqkRARKAMRNGIsPIIIDNTNLHAWEMKPYAVMALENNYEVIF 234
Cdd:COG4639    23 FAPTEVVSSDDIralLGGDENDQSAWGDVFQLAHE----IARARLRAGR-LTVVDATNLQREARRRLLALARAYGALVVA 97

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1217320108 235 repdtrWKFNV--QELARRNI---HGVSREKIHRMKERYEH 270
Cdd:COG4639    98 ------VVLDVplEVCLARNAardRQVPEEVIRRMLRRLRR 132
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
44-60 1.25e-03

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 39.13  E-value: 1.25e-03
                          10
                  ....*....|....*..
gi 1217320108  44 LYLLRGLPGSGKTTLAR 60
Cdd:COG0645     1 LILVCGLPGSGKSTLAR 17
KaiC-like_N cd19488
N-terminal domain of KaiC family protein; uncharacterized subfamily; KaiC is a circadian clock ...
 41-59 1.69e-03

N-terminal domain of KaiC family protein; uncharacterized subfamily; KaiC is a circadian clock protein, most studied in cyanobacteria. KaiC, an autokinase, autophosphatase, and ATPase, is part of the core oscillator, composed of three proteins: KaiA, KaiB, and KaiC. The circadian oscillation is regulated via KaiC phosphorylation.


Pssm-ID: 410896 [Multi-domain]  Cd Length: 225  Bit Score: 39.25  E-value: 1.69e-03
                          10
                  ....*....|....*....
gi 1217320108  41 RKHLYLLRGLPGSGKTTLA 59
Cdd:cd19488    18 PRRLYLVEGAPGTGKTTLA 36
 
Name Accession Description Interval E-value
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 165-269 3.52e-10

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 57.32  E-value: 3.52e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1217320108 165 STDDFFFR----EDGAYEFNPDFLEEAHEWNQKRARKAMRNGIsPIIIDNTNLHAWEMKPYAVMALENNYE---VIFREP 237
Cdd:pfam13671  29 SSDDERKRlfgeGRPSISYYTDATDRTYERLHELARIALRAGR-PVILDATNLRRDERARLLALAREYGVPvriVVFEAP 107

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1217320108 238 DTRWKFNVQELARRNIHG--VSREKIHRMKERYE 269
Cdd:pfam13671 108 EEVLRERLAARARAGGDPsdVPEEVLDRQKARFE 141
COG4639 COG4639
Predicted kinase [General function prediction only];
158-270 4.23e-06

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 45.98  E-value: 4.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1217320108 158 FPRALIFSTDDF---FFREDGAYEFNPDFLEEAHEwnqkRARKAMRNGIsPIIIDNTNLHAWEMKPYAVMALENNYEVIF 234
Cdd:COG4639    23 FAPTEVVSSDDIralLGGDENDQSAWGDVFQLAHE----IARARLRAGR-LTVVDATNLQREARRRLLALARAYGALVVA 97

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1217320108 235 repdtrWKFNV--QELARRNI---HGVSREKIHRMKERYEH 270
Cdd:COG4639    98 ------VVLDVplEVCLARNAardRQVPEEVIRRMLRRLRR 132
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
44-60 1.25e-03

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 39.13  E-value: 1.25e-03
                          10
                  ....*....|....*..
gi 1217320108  44 LYLLRGLPGSGKTTLAR 60
Cdd:COG0645     1 LILVCGLPGSGKSTLAR 17
KaiC-like_N cd19488
N-terminal domain of KaiC family protein; uncharacterized subfamily; KaiC is a circadian clock ...
 41-59 1.69e-03

N-terminal domain of KaiC family protein; uncharacterized subfamily; KaiC is a circadian clock protein, most studied in cyanobacteria. KaiC, an autokinase, autophosphatase, and ATPase, is part of the core oscillator, composed of three proteins: KaiA, KaiB, and KaiC. The circadian oscillation is regulated via KaiC phosphorylation.


Pssm-ID: 410896 [Multi-domain]  Cd Length: 225  Bit Score: 39.25  E-value: 1.69e-03
                          10
                  ....*....|....*....
gi 1217320108  41 RKHLYLLRGLPGSGKTTLA 59
Cdd:cd19488    18 PRRLYLVEGAPGTGKTTLA 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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