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Conserved domains on  [gi|1217323488|ref|NP_001340553|]
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SREBP regulating gene protein isoform 3 [Homo sapiens]

Protein Classification

SPRING family protein( domain architecture ID 5338)

SPRING (SREBF pathway regulator in Golgi 1) family protein (formerly called DUF2054), similar to Homo sapiens SREBP regulating gene protein that positively regulates hepatic SREBP signaling pathway by modulating the proper localization of SCAP (SREBP cleavage-activating protein) to the endoplasmic reticulum

Gene Ontology:  GO:2000640

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SPRING1 super family cl10907
SREBP regulating gene protein; SPRING1 is a glycosylated Golgi-resident membrane protein ...
 36-92 8.93e-31

SREBP regulating gene protein; SPRING1 is a glycosylated Golgi-resident membrane protein involved in SREBP signaling and cholesterol metabolism. It modulates the proper localization of SCAP (SREBP cleavage-activating protein) to the endoplasmic reticulum, thereby controlling the level of functional SCAP.


The actual alignment was detected with superfamily member pfam10218:

Pssm-ID: 463004  Cd Length: 128  Bit Score: 105.53  E-value: 8.93e-31
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1217323488  36 KQQLLLERFLNRAAVAFQNLFMAVEDHFELCLAKCRTSSQSVQHENTYRDPIAKYCY 92
Cdd:pfam10218  72 DKRPLLEVVLKKARGRTQVLYGSVTDHFELCLAKCRTSSHSVQHENTYRDPDAKHCY 128
 
Name Accession Description Interval E-value
SPRING1 pfam10218
SREBP regulating gene protein; SPRING1 is a glycosylated Golgi-resident membrane protein ...
 36-92 8.93e-31

SREBP regulating gene protein; SPRING1 is a glycosylated Golgi-resident membrane protein involved in SREBP signaling and cholesterol metabolism. It modulates the proper localization of SCAP (SREBP cleavage-activating protein) to the endoplasmic reticulum, thereby controlling the level of functional SCAP.


Pssm-ID: 463004  Cd Length: 128  Bit Score: 105.53  E-value: 8.93e-31
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1217323488  36 KQQLLLERFLNRAAVAFQNLFMAVEDHFELCLAKCRTSSQSVQHENTYRDPIAKYCY 92
Cdd:pfam10218  72 DKRPLLEVVLKKARGRTQVLYGSVTDHFELCLAKCRTSSHSVQHENTYRDPDAKHCY 128
 
Name Accession Description Interval E-value
SPRING1 pfam10218
SREBP regulating gene protein; SPRING1 is a glycosylated Golgi-resident membrane protein ...
 36-92 8.93e-31

SREBP regulating gene protein; SPRING1 is a glycosylated Golgi-resident membrane protein involved in SREBP signaling and cholesterol metabolism. It modulates the proper localization of SCAP (SREBP cleavage-activating protein) to the endoplasmic reticulum, thereby controlling the level of functional SCAP.


Pssm-ID: 463004  Cd Length: 128  Bit Score: 105.53  E-value: 8.93e-31
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1217323488  36 KQQLLLERFLNRAAVAFQNLFMAVEDHFELCLAKCRTSSQSVQHENTYRDPIAKYCY 92
Cdd:pfam10218  72 DKRPLLEVVLKKARGRTQVLYGSVTDHFELCLAKCRTSSHSVQHENTYRDPDAKHCY 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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