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Conserved domains on  [gi|1212988829|ref|NP_001340084|]
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coiled-coil domain-containing protein 66 isoform 9 [Homo sapiens]

Protein Classification

CCDC66 domain-containing protein( domain architecture ID 12172167)

CCDC66 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CCDC66 pfam15236
Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil ...
 361-514 9.49e-55

Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil domain-containing protein 66 (CCDC) refers to a protein domain found in eukaryotes, and is approximately 160 amino acids in length. CCDC66 protein is detected mainly in the inner segments of photoreceptors in many vertebrates including mice and humans. It has been found in dogs, that a mutation in the CCDC66 gene causes generalized progressive retinal atrophy (gPRA). This shows that the protein encoded for by this gene is vital for healthy vision and guards against photoreceptor cell degeneration. The structure of CCDC66 proteins includes a heptad repeat pattern which contains at least one coiled-coil domain. There are at least two or more alpha-helices which form a cable-like structure.


:

Pssm-ID: 434558 [Multi-domain]  Cd Length: 154  Bit Score: 186.54  E-value: 9.49e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212988829 361 TTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRK 440
Cdd:pfam15236   1 TDLKVVSPDDVESLQSSSRMSAMTNSQKTSFLRGQNALLDPAQLEERERKRQKALEHQNAIKKQLEEKERQKKLEEERRR 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1212988829 441 KEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQKGHDTSR 514
Cdd:pfam15236  81 QEEQEEEERLRREREEEQKQFEEERRKQKEKEEAMTRKTQALLQAMQKAQELAQRLKQEQRIRELAEKGHDTSQ 154
 
Name Accession Description Interval E-value
CCDC66 pfam15236
Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil ...
 361-514 9.49e-55

Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil domain-containing protein 66 (CCDC) refers to a protein domain found in eukaryotes, and is approximately 160 amino acids in length. CCDC66 protein is detected mainly in the inner segments of photoreceptors in many vertebrates including mice and humans. It has been found in dogs, that a mutation in the CCDC66 gene causes generalized progressive retinal atrophy (gPRA). This shows that the protein encoded for by this gene is vital for healthy vision and guards against photoreceptor cell degeneration. The structure of CCDC66 proteins includes a heptad repeat pattern which contains at least one coiled-coil domain. There are at least two or more alpha-helices which form a cable-like structure.


Pssm-ID: 434558 [Multi-domain]  Cd Length: 154  Bit Score: 186.54  E-value: 9.49e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212988829 361 TTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRK 440
Cdd:pfam15236   1 TDLKVVSPDDVESLQSSSRMSAMTNSQKTSFLRGQNALLDPAQLEERERKRQKALEHQNAIKKQLEEKERQKKLEEERRR 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1212988829 441 KEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQKGHDTSR 514
Cdd:pfam15236  81 QEEQEEEERLRREREEEQKQFEEERRKQKEKEEAMTRKTQALLQAMQKAQELAQRLKQEQRIRELAEKGHDTSQ 154
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 402-515 7.50e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 40.31  E-value: 7.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212988829 402 AQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDILKQKQKEEImTLKTNE 481
Cdd:COG1196   326 AELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAEL-AAQLEE 404

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1212988829 482 LFQTMQRAQELAQRLKQEQRIRELAQKGHDTSRL 515
Cdd:COG1196   405 LEEAEEALLERLERLEEELEELEEALAELEEEEE 438
 
Name Accession Description Interval E-value
CCDC66 pfam15236
Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil ...
 361-514 9.49e-55

Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil domain-containing protein 66 (CCDC) refers to a protein domain found in eukaryotes, and is approximately 160 amino acids in length. CCDC66 protein is detected mainly in the inner segments of photoreceptors in many vertebrates including mice and humans. It has been found in dogs, that a mutation in the CCDC66 gene causes generalized progressive retinal atrophy (gPRA). This shows that the protein encoded for by this gene is vital for healthy vision and guards against photoreceptor cell degeneration. The structure of CCDC66 proteins includes a heptad repeat pattern which contains at least one coiled-coil domain. There are at least two or more alpha-helices which form a cable-like structure.


Pssm-ID: 434558 [Multi-domain]  Cd Length: 154  Bit Score: 186.54  E-value: 9.49e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212988829 361 TTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRK 440
Cdd:pfam15236   1 TDLKVVSPDDVESLQSSSRMSAMTNSQKTSFLRGQNALLDPAQLEERERKRQKALEHQNAIKKQLEEKERQKKLEEERRR 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1212988829 441 KEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQKGHDTSR 514
Cdd:pfam15236  81 QEEQEEEERLRREREEEQKQFEEERRKQKEKEEAMTRKTQALLQAMQKAQELAQRLKQEQRIRELAEKGHDTSQ 154
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 402-506 8.50e-04

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 42.60  E-value: 8.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212988829 402 AQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQeeelrlaQEREEMQKQYEEDILKQKQKEEimtlKTNE 481
Cdd:pfam13868  59 EEEEKEEERKEERKRYRQELEEQIEEREQKRQEEYEEKLQERE-------QMDEIVERIQEEDQAEAEEKLE----KQRQ 127

                          90       100
                  ....*....|....*....|....*
gi 1212988829 482 LFQTMQRAQELAQRLKQEQRIRELA 506
Cdd:pfam13868 128 LREEIDEFNEEQAEWKELEKEEERE 152
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 402-515 7.50e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 40.31  E-value: 7.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212988829 402 AQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDILKQKQKEEImTLKTNE 481
Cdd:COG1196   326 AELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAEL-AAQLEE 404

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1212988829 482 LFQTMQRAQELAQRLKQEQRIRELAQKGHDTSRL 515
Cdd:COG1196   405 LEEAEEALLERLERLEEELEELEEALAELEEEEE 438
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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