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Conserved domains on  [gi|1209601091|ref|NP_001339817|]
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cortexin domain-containing 1 protein [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cortexin super family cl12620
Cortexin of kidney; In the middle of cortexin protein there is a single membrane-spanning ...
 5-54 3.01e-12

Cortexin of kidney; In the middle of cortexin protein there is a single membrane-spanning domain which indicates that this protein may be a membrane protein involved in intracellular or extracellular signalling of the kidney or brain, since it is expressed specifically in the kidneys and brain only. The protein is highly conserved among species. Cortexin is also thought to be important to neurons of both the developing and adult cerebral cortex.


The actual alignment was detected with superfamily member pfam11057:

Pssm-ID: 314086  Cd Length: 73  Bit Score: 55.18  E-value: 3.01e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 1209601091  5 TPEPVYVDVDKGLTLACFVFLCLFLVVMIIRCAKVIMDPYSAIPTSTWEE 54
Cdd:pfam11057  9 PPSASSLTLEQKTVFAFVGLLLIFLGLLIVRCFRILLDPYSSMPSSTWTD 58
 
Name Accession Description Interval E-value
Cortexin pfam11057
Cortexin of kidney; In the middle of cortexin protein there is a single membrane-spanning ...
 5-54 3.01e-12

Cortexin of kidney; In the middle of cortexin protein there is a single membrane-spanning domain which indicates that this protein may be a membrane protein involved in intracellular or extracellular signalling of the kidney or brain, since it is expressed specifically in the kidneys and brain only. The protein is highly conserved among species. Cortexin is also thought to be important to neurons of both the developing and adult cerebral cortex.


Pssm-ID: 314086  Cd Length: 73  Bit Score: 55.18  E-value: 3.01e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 1209601091  5 TPEPVYVDVDKGLTLACFVFLCLFLVVMIIRCAKVIMDPYSAIPTSTWEE 54
Cdd:pfam11057  9 PPSASSLTLEQKTVFAFVGLLLIFLGLLIVRCFRILLDPYSSMPSSTWTD 58
 
Name Accession Description Interval E-value
Cortexin pfam11057
Cortexin of kidney; In the middle of cortexin protein there is a single membrane-spanning ...
 5-54 3.01e-12

Cortexin of kidney; In the middle of cortexin protein there is a single membrane-spanning domain which indicates that this protein may be a membrane protein involved in intracellular or extracellular signalling of the kidney or brain, since it is expressed specifically in the kidneys and brain only. The protein is highly conserved among species. Cortexin is also thought to be important to neurons of both the developing and adult cerebral cortex.


Pssm-ID: 314086  Cd Length: 73  Bit Score: 55.18  E-value: 3.01e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 1209601091  5 TPEPVYVDVDKGLTLACFVFLCLFLVVMIIRCAKVIMDPYSAIPTSTWEE 54
Cdd:pfam11057  9 PPSASSLTLEQKTVFAFVGLLLIFLGLLIVRCFRILLDPYSSMPSSTWTD 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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