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Conserved domains on  [gi|1209601078|ref|NP_001339807|]
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suppression of tumorigenicity 18 protein isoform e [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MYT1 pfam08474
Myelin transcription factor 1; This domain is found in the myelin transcription factor 1 (MYT1) ...
 126-362 6.59e-112

Myelin transcription factor 1; This domain is found in the myelin transcription factor 1 (MYT1) of chordates. MYT1 contains C2HC zinc finger domains (pfam01530) and is expressed in developing neurons of the central nervous system where it is involved in the selection of neuronal precursor cells.


:

Pssm-ID: 462489 [Multi-domain]  Cd Length: 237  Bit Score: 337.11  E-value: 6.59e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209601078 126 PSQAITSPRATVSKEQEKFGKVPFDYASFDAQVFGKRPLIQTVQGRKTPP--FPESKHFPNPVKFPNRLPSAGAHTQSPG 203
Cdd:pfam08474   3 NNVPTTTPRANLAKELEKYSKTSFDYASFDAQVFGKRTLAPKVQGQDTSPkgFDAKKYFCKPSSPSSSLTSSYAPSSSSS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209601078 204 RASSYSYGQCSEDTHIAAAAAiLNLSTRCREATDILSNKPQSLHAKGAEIEVDENGTLDLSMKKNRILDksapLTSSNTS 283
Cdd:pfam08474  83 SSSSYDYTHDMEAAHMAATAI-LNLSTRCREMPENLSTKPQDLSAKPDDIEVDENGTLDLSMKKNRPRG----VTSGSVL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209601078 284 IPTPSSSPFKTSSILvNAAFYQALCDQEGWDTPINYSKTHGKTEEEKE--KDPVSSLENLEEKKFPGEASIPSPKPKLHA 361
Cdd:pfam08474 158 TPLPPMSPQRQASLL-NSRCYQALCAQDCWDLPVDYTKIKRIDEEEKEepEDLDPFQELLEERKYPGEVTIPSPKPKYPP 236


                  .
gi 1209601078 362 R 362
Cdd:pfam08474 237 C 237
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 414-442 2.22e-16

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


:

Pssm-ID: 460240  Cd Length: 29  Bit Score: 72.95  E-value: 2.22e-16
                          10        20
                  ....*....|....*....|....*....
gi 1209601078 414 KCPTPGCDGSGHVTGNYASHRSLSGCPRA 442
Cdd:pfam01530   1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 370-398 1.25e-15

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


:

Pssm-ID: 460240  Cd Length: 29  Bit Score: 70.64  E-value: 1.25e-15
                          10        20
                  ....*....|....*....|....*....
gi 1209601078 370 TCPTPGCDGSGHVTGNYASHRSVSGCPLA 398
Cdd:pfam01530   1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 58-86 8.35e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


:

Pssm-ID: 460240  Cd Length: 29  Bit Score: 65.63  E-value: 8.35e-14
                          10        20
                  ....*....|....*....|....*....
gi 1209601078  58 KCPTPGCTGRGHVNSNRNTHRSLSGCPIA 86
Cdd:pfam01530   1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 462-490 9.03e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


:

Pssm-ID: 460240  Cd Length: 29  Bit Score: 65.25  E-value: 9.03e-14
                          10        20
                  ....*....|....*....|....*....
gi 1209601078 462 KCPVIGCDGQGHISGKYTSHRTASGCPLA 490
Cdd:pfam01530   1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 14-40 1.08e-12

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


:

Pssm-ID: 460240  Cd Length: 29  Bit Score: 62.17  E-value: 1.08e-12
                          10        20
                  ....*....|....*....|....*..
gi 1209601078  14 KCPIPGCDGTGHVTGLYPHHRSLSGCP 40
Cdd:pfam01530   1 KCPTPGCDGSGHVSGKYATHRSLSGCP 27
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 516-542 7.37e-11

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


:

Pssm-ID: 460240  Cd Length: 29  Bit Score: 57.16  E-value: 7.37e-11
                          10        20
                  ....*....|....*....|....*..
gi 1209601078 516 CPLPGCNGLGHVNNVFVTHRSLSGCPL 542
Cdd:pfam01530   2 CPTPGCDGSGHVSGKYATHRSLSGCPY 28
Atg16_CCD super family cl46300
Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family ...
 570-619 3.55e-05

Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family includes Saccharomyces cerevisiae Atg16 (also called cytoplasm to vacuole targeting protein 11, CVT11, or SAP18), human autophagy-related protein 16-1 (also called APG16-like 1, ATG16L1, or APG16L) and autophagy-related protein 16-2 (also called APG16-like 2, ATG16L2, WD repeat-containing protein 80 or WDR80), and similar proteins. Atg16 stabilizes the Atg5-Atg12 conjugate and mediates the formation of the 350 kDa complex, which is necessary for autophagy. The Atg5-Atg12/Atg16 complex is required for efficient promotion of Atg8-conjugation to phosphatidylethanolamine and Atg8 localization to the pre-autophagosomal structure (PAS). Similarly, human ATG16L1 plays an essential role in autophagy and acts as a molecular scaffold which mediates protein-protein interactions essential for autophagosome formation. ATG16L2, though structurally similar to ATG16L1 and able to form a complex with the autophagy proteins Atg5 and Atg12, is not essential for autophagy. Single-nucleotide polymorphisms in ATG16L1 is associated with an increased risk of developing Crohn disease. Saccharomyces cerevisiae Atg16 contains an N-terminal domain (NTD) that interacts with the Atg5-Atg12 protein conjugate and a coiled-coil domain (CCD) that dimerizes and mediates self-assembly. Human ATG16L1 and ATG16L2 also contains an N-terminal region that binds Atg5, a CCD homologous to the yeast CCD, and a WD40 domain that represents approximately 50% of the full-length protein. This model corresponds to the CCD of Atg16 family proteins.


The actual alignment was detected with superfamily member cd22887:

Pssm-ID: 480640 [Multi-domain]  Cd Length: 91  Bit Score: 42.94  E-value: 3.55e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1209601078 570 DEEIRHLDEEIKELNESNLKIEADMMKLQTQITSMESNLKTIEEEN-KLIE 619
Cdd:cd22887    24 EEEIKDLEEELKEKNKANEILNDELIALQIENNLLEEKLRKLQEENdELVE 74
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
542-647 5.85e-05

Uncharacterized protein, contains DUF3084 domain [Function unknown];


:

Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 46.05  E-value: 5.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209601078 542 LNAQVIKKGKVSEELMTIKLKATggiESDEEIRHLDEEIKELNESNLKIEADMMKLQTQITSMESNLKTIEEENKLIEQN 621
Cdd:COG4372    89 LQAAQAELAQAQEELESLQEEAE---ELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEE 165

                          90       100
                  ....*....|....*....|....*.
gi 1209601078 622 NESLLKELAGLSQALISSLADIQLPQ 647
Cdd:COG4372   166 LAALEQELQALSEAEAEQALDELLKE 191
 
Name Accession Description Interval E-value
MYT1 pfam08474
Myelin transcription factor 1; This domain is found in the myelin transcription factor 1 (MYT1) ...
 126-362 6.59e-112

Myelin transcription factor 1; This domain is found in the myelin transcription factor 1 (MYT1) of chordates. MYT1 contains C2HC zinc finger domains (pfam01530) and is expressed in developing neurons of the central nervous system where it is involved in the selection of neuronal precursor cells.


Pssm-ID: 462489 [Multi-domain]  Cd Length: 237  Bit Score: 337.11  E-value: 6.59e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209601078 126 PSQAITSPRATVSKEQEKFGKVPFDYASFDAQVFGKRPLIQTVQGRKTPP--FPESKHFPNPVKFPNRLPSAGAHTQSPG 203
Cdd:pfam08474   3 NNVPTTTPRANLAKELEKYSKTSFDYASFDAQVFGKRTLAPKVQGQDTSPkgFDAKKYFCKPSSPSSSLTSSYAPSSSSS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209601078 204 RASSYSYGQCSEDTHIAAAAAiLNLSTRCREATDILSNKPQSLHAKGAEIEVDENGTLDLSMKKNRILDksapLTSSNTS 283
Cdd:pfam08474  83 SSSSYDYTHDMEAAHMAATAI-LNLSTRCREMPENLSTKPQDLSAKPDDIEVDENGTLDLSMKKNRPRG----VTSGSVL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209601078 284 IPTPSSSPFKTSSILvNAAFYQALCDQEGWDTPINYSKTHGKTEEEKE--KDPVSSLENLEEKKFPGEASIPSPKPKLHA 361
Cdd:pfam08474 158 TPLPPMSPQRQASLL-NSRCYQALCAQDCWDLPVDYTKIKRIDEEEKEepEDLDPFQELLEERKYPGEVTIPSPKPKYPP 236


                  .
gi 1209601078 362 R 362
Cdd:pfam08474 237 C 237
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 414-442 2.22e-16

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 72.95  E-value: 2.22e-16
                          10        20
                  ....*....|....*....|....*....
gi 1209601078 414 KCPTPGCDGSGHVTGNYASHRSLSGCPRA 442
Cdd:pfam01530   1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 370-398 1.25e-15

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 70.64  E-value: 1.25e-15
                          10        20
                  ....*....|....*....|....*....
gi 1209601078 370 TCPTPGCDGSGHVTGNYASHRSVSGCPLA 398
Cdd:pfam01530   1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 58-86 8.35e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 65.63  E-value: 8.35e-14
                          10        20
                  ....*....|....*....|....*....
gi 1209601078  58 KCPTPGCTGRGHVNSNRNTHRSLSGCPIA 86
Cdd:pfam01530   1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 462-490 9.03e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 65.25  E-value: 9.03e-14
                          10        20
                  ....*....|....*....|....*....
gi 1209601078 462 KCPVIGCDGQGHISGKYTSHRTASGCPLA 490
Cdd:pfam01530   1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 14-40 1.08e-12

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 62.17  E-value: 1.08e-12
                          10        20
                  ....*....|....*....|....*..
gi 1209601078  14 KCPIPGCDGTGHVTGLYPHHRSLSGCP 40
Cdd:pfam01530   1 KCPTPGCDGSGHVSGKYATHRSLSGCP 27
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 516-542 7.37e-11

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 57.16  E-value: 7.37e-11
                          10        20
                  ....*....|....*....|....*..
gi 1209601078 516 CPLPGCNGLGHVNNVFVTHRSLSGCPL 542
Cdd:pfam01530   2 CPTPGCDGSGHVSGKYATHRSLSGCPY 28
Atg16_CCD cd22887
Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family ...
 570-619 3.55e-05

Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family includes Saccharomyces cerevisiae Atg16 (also called cytoplasm to vacuole targeting protein 11, CVT11, or SAP18), human autophagy-related protein 16-1 (also called APG16-like 1, ATG16L1, or APG16L) and autophagy-related protein 16-2 (also called APG16-like 2, ATG16L2, WD repeat-containing protein 80 or WDR80), and similar proteins. Atg16 stabilizes the Atg5-Atg12 conjugate and mediates the formation of the 350 kDa complex, which is necessary for autophagy. The Atg5-Atg12/Atg16 complex is required for efficient promotion of Atg8-conjugation to phosphatidylethanolamine and Atg8 localization to the pre-autophagosomal structure (PAS). Similarly, human ATG16L1 plays an essential role in autophagy and acts as a molecular scaffold which mediates protein-protein interactions essential for autophagosome formation. ATG16L2, though structurally similar to ATG16L1 and able to form a complex with the autophagy proteins Atg5 and Atg12, is not essential for autophagy. Single-nucleotide polymorphisms in ATG16L1 is associated with an increased risk of developing Crohn disease. Saccharomyces cerevisiae Atg16 contains an N-terminal domain (NTD) that interacts with the Atg5-Atg12 protein conjugate and a coiled-coil domain (CCD) that dimerizes and mediates self-assembly. Human ATG16L1 and ATG16L2 also contains an N-terminal region that binds Atg5, a CCD homologous to the yeast CCD, and a WD40 domain that represents approximately 50% of the full-length protein. This model corresponds to the CCD of Atg16 family proteins.


Pssm-ID: 439196 [Multi-domain]  Cd Length: 91  Bit Score: 42.94  E-value: 3.55e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1209601078 570 DEEIRHLDEEIKELNESNLKIEADMMKLQTQITSMESNLKTIEEEN-KLIE 619
Cdd:cd22887    24 EEEIKDLEEELKEKNKANEILNDELIALQIENNLLEEKLRKLQEENdELVE 74
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
542-647 5.85e-05

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 46.05  E-value: 5.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209601078 542 LNAQVIKKGKVSEELMTIKLKATggiESDEEIRHLDEEIKELNESNLKIEADMMKLQTQITSMESNLKTIEEENKLIEQN 621
Cdd:COG4372    89 LQAAQAELAQAQEELESLQEEAE---ELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEE 165

                          90       100
                  ....*....|....*....|....*.
gi 1209601078 622 NESLLKELAGLSQALISSLADIQLPQ 647
Cdd:COG4372   166 LAALEQELQALSEAEAEQALDELLKE 191
PRK13676 PRK13676
YlbF/YmcA family competence regulator;
568-653 6.21e-05

YlbF/YmcA family competence regulator;


Pssm-ID: 237467 [Multi-domain]  Cd Length: 114  Bit Score: 42.62  E-value: 6.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209601078 568 ESDEEIRHLDE--EIKEL------NESNLKIEADMMKLQTQITSMESNLKTIEEE--------NKLIEQNneSLLKELAG 631
Cdd:PRK13676   11 ELERALRELPEykALKEAkeavkaDEEAKKLFDEFRALQLEIQQKQMTGQEITEEeqqkaqelGQKIQQN--ELLSKLME 88

                          90       100
                  ....*....|....*....|..
gi 1209601078 632 LSQALISSLADIQLPQMGPISE 653
Cdd:PRK13676   89 AEQRLSVYINDINKIIFKPLEE 110
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 568-643 7.52e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 39.62  E-value: 7.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209601078 568 ESDEEIRHLDEEIKELNESNLKIEADMMKLQTQITSMESNLKTIEEENKL-------IEQNNESLLKELAGLSQALISSL 640
Cdd:TIGR04523 360 EKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQkdeqikkLQQEKELLEKEIERLKETIIKNN 439


                  ...
gi 1209601078 641 ADI 643
Cdd:TIGR04523 440 SEI 442
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 567-644 8.95e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.53  E-value: 8.95e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1209601078 567 IESDEEIRHLDEEIKELNESNLKIEADMMKLQTQITSMESNLKTIEEENKLIEQNNESLLKELAGLSQALISSLADIQ 644
Cdd:COG1196   298 ARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELA 375
ATG16 pfam08614
Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for ...
 571-619 9.97e-03

Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for eukaryotic cells. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. ATG16 (also known as Apg16) has been shown to be bind to Apg5 and is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway.


Pssm-ID: 462536 [Multi-domain]  Cd Length: 176  Bit Score: 37.60  E-value: 9.97e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1209601078 571 EEIRHLDEEIKELNESNLKIEADMMKLQTQITSMESNLKTIEEENK-LIE 619
Cdd:pfam08614 113 EKLKDREEELREKRKLNQDLQDELVALQLQLNMAEEKLRKLEKENReLVE 162
 
Name Accession Description Interval E-value
MYT1 pfam08474
Myelin transcription factor 1; This domain is found in the myelin transcription factor 1 (MYT1) ...
 126-362 6.59e-112

Myelin transcription factor 1; This domain is found in the myelin transcription factor 1 (MYT1) of chordates. MYT1 contains C2HC zinc finger domains (pfam01530) and is expressed in developing neurons of the central nervous system where it is involved in the selection of neuronal precursor cells.


Pssm-ID: 462489 [Multi-domain]  Cd Length: 237  Bit Score: 337.11  E-value: 6.59e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209601078 126 PSQAITSPRATVSKEQEKFGKVPFDYASFDAQVFGKRPLIQTVQGRKTPP--FPESKHFPNPVKFPNRLPSAGAHTQSPG 203
Cdd:pfam08474   3 NNVPTTTPRANLAKELEKYSKTSFDYASFDAQVFGKRTLAPKVQGQDTSPkgFDAKKYFCKPSSPSSSLTSSYAPSSSSS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209601078 204 RASSYSYGQCSEDTHIAAAAAiLNLSTRCREATDILSNKPQSLHAKGAEIEVDENGTLDLSMKKNRILDksapLTSSNTS 283
Cdd:pfam08474  83 SSSSYDYTHDMEAAHMAATAI-LNLSTRCREMPENLSTKPQDLSAKPDDIEVDENGTLDLSMKKNRPRG----VTSGSVL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209601078 284 IPTPSSSPFKTSSILvNAAFYQALCDQEGWDTPINYSKTHGKTEEEKE--KDPVSSLENLEEKKFPGEASIPSPKPKLHA 361
Cdd:pfam08474 158 TPLPPMSPQRQASLL-NSRCYQALCAQDCWDLPVDYTKIKRIDEEEKEepEDLDPFQELLEERKYPGEVTIPSPKPKYPP 236


                  .
gi 1209601078 362 R 362
Cdd:pfam08474 237 C 237
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 414-442 2.22e-16

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 72.95  E-value: 2.22e-16
                          10        20
                  ....*....|....*....|....*....
gi 1209601078 414 KCPTPGCDGSGHVTGNYASHRSLSGCPRA 442
Cdd:pfam01530   1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 370-398 1.25e-15

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 70.64  E-value: 1.25e-15
                          10        20
                  ....*....|....*....|....*....
gi 1209601078 370 TCPTPGCDGSGHVTGNYASHRSVSGCPLA 398
Cdd:pfam01530   1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 58-86 8.35e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 65.63  E-value: 8.35e-14
                          10        20
                  ....*....|....*....|....*....
gi 1209601078  58 KCPTPGCTGRGHVNSNRNTHRSLSGCPIA 86
Cdd:pfam01530   1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 462-490 9.03e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 65.25  E-value: 9.03e-14
                          10        20
                  ....*....|....*....|....*....
gi 1209601078 462 KCPVIGCDGQGHISGKYTSHRTASGCPLA 490
Cdd:pfam01530   1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 14-40 1.08e-12

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 62.17  E-value: 1.08e-12
                          10        20
                  ....*....|....*....|....*..
gi 1209601078  14 KCPIPGCDGTGHVTGLYPHHRSLSGCP 40
Cdd:pfam01530   1 KCPTPGCDGSGHVSGKYATHRSLSGCP 27
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 516-542 7.37e-11

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 57.16  E-value: 7.37e-11
                          10        20
                  ....*....|....*....|....*..
gi 1209601078 516 CPLPGCNGLGHVNNVFVTHRSLSGCPL 542
Cdd:pfam01530   2 CPTPGCDGSGHVSGKYATHRSLSGCPY 28
Atg16_CCD cd22887
Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family ...
 570-619 3.55e-05

Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family includes Saccharomyces cerevisiae Atg16 (also called cytoplasm to vacuole targeting protein 11, CVT11, or SAP18), human autophagy-related protein 16-1 (also called APG16-like 1, ATG16L1, or APG16L) and autophagy-related protein 16-2 (also called APG16-like 2, ATG16L2, WD repeat-containing protein 80 or WDR80), and similar proteins. Atg16 stabilizes the Atg5-Atg12 conjugate and mediates the formation of the 350 kDa complex, which is necessary for autophagy. The Atg5-Atg12/Atg16 complex is required for efficient promotion of Atg8-conjugation to phosphatidylethanolamine and Atg8 localization to the pre-autophagosomal structure (PAS). Similarly, human ATG16L1 plays an essential role in autophagy and acts as a molecular scaffold which mediates protein-protein interactions essential for autophagosome formation. ATG16L2, though structurally similar to ATG16L1 and able to form a complex with the autophagy proteins Atg5 and Atg12, is not essential for autophagy. Single-nucleotide polymorphisms in ATG16L1 is associated with an increased risk of developing Crohn disease. Saccharomyces cerevisiae Atg16 contains an N-terminal domain (NTD) that interacts with the Atg5-Atg12 protein conjugate and a coiled-coil domain (CCD) that dimerizes and mediates self-assembly. Human ATG16L1 and ATG16L2 also contains an N-terminal region that binds Atg5, a CCD homologous to the yeast CCD, and a WD40 domain that represents approximately 50% of the full-length protein. This model corresponds to the CCD of Atg16 family proteins.


Pssm-ID: 439196 [Multi-domain]  Cd Length: 91  Bit Score: 42.94  E-value: 3.55e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1209601078 570 DEEIRHLDEEIKELNESNLKIEADMMKLQTQITSMESNLKTIEEEN-KLIE 619
Cdd:cd22887    24 EEEIKDLEEELKEKNKANEILNDELIALQIENNLLEEKLRKLQEENdELVE 74
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
542-647 5.85e-05

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 46.05  E-value: 5.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209601078 542 LNAQVIKKGKVSEELMTIKLKATggiESDEEIRHLDEEIKELNESNLKIEADMMKLQTQITSMESNLKTIEEENKLIEQN 621
Cdd:COG4372    89 LQAAQAELAQAQEELESLQEEAE---ELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEE 165

                          90       100
                  ....*....|....*....|....*.
gi 1209601078 622 NESLLKELAGLSQALISSLADIQLPQ 647
Cdd:COG4372   166 LAALEQELQALSEAEAEQALDELLKE 191
PRK13676 PRK13676
YlbF/YmcA family competence regulator;
568-653 6.21e-05

YlbF/YmcA family competence regulator;


Pssm-ID: 237467 [Multi-domain]  Cd Length: 114  Bit Score: 42.62  E-value: 6.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209601078 568 ESDEEIRHLDE--EIKEL------NESNLKIEADMMKLQTQITSMESNLKTIEEE--------NKLIEQNneSLLKELAG 631
Cdd:PRK13676   11 ELERALRELPEykALKEAkeavkaDEEAKKLFDEFRALQLEIQQKQMTGQEITEEeqqkaqelGQKIQQN--ELLSKLME 88

                          90       100
                  ....*....|....*....|..
gi 1209601078 632 LSQALISSLADIQLPQMGPISE 653
Cdd:PRK13676   89 AEQRLSVYINDINKIIFKPLEE 110
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 537-692 2.21e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.98  E-value: 2.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209601078 537 LSGCPLNAQVIKKGKVSEELMTIKlkatggiesdEEIRHLDEEIKELNESNLKIEADMMKLQTQITSMESNLKTIEEENK 616
Cdd:COG4942    10 LLALAAAAQADAAAEAEAELEQLQ----------QEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209601078 617 LIEQNNESLLKELAGLSQALISSLADIQ-----LPQMGPISEQNFEAYVNTLTDMYSNLE--RDYSPECKALLESIKQAV 689
Cdd:COG4942    80 ALEAELAELEKEIAELRAELEAQKEELAellraLYRLGRQPPLALLLSPEDFLDAVRRLQylKYLAPARREQAEELRADL 159


                  ...
gi 1209601078 690 KGI 692
Cdd:COG4942   160 AEL 162
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
568-690 4.76e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 42.97  E-value: 4.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209601078 568 ESDEEIRHLDEEIKELNESnLKieadmmKLQTQITSMESNLKTIEEENKLIEQNNESLLKELAGLSQALISSLADIQLPQ 647
Cdd:COG4372    70 QARSELEQLEEELEELNEQ-LQ------AAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQ 142

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1209601078 648 MGPISEQN----FEAYVNTLTDMYSNLERDYSPECKALLES-IKQAVK 690
Cdd:COG4372   143 SEIAEREEelkeLEEQLESLQEELAALEQELQALSEAEAEQaLDELLK 190
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 568-690 2.25e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 40.97  E-value: 2.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209601078 568 ESDEEIRHLDEEIKELNESNLKIEADMMKLQTQITSMESNLKTIEEEnklIEQNNEsLLKELAGLSQ---ALISSLADIq 644
Cdd:COG3883    34 AAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAE---IEERRE-ELGERARALYrsgGSVSYLDVL- 108

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1209601078 645 lpqmgpISEQNFEAYVNTLTDMYSNLERDyspecKALLESIKQAVK 690
Cdd:COG3883   109 ------LGSESFSDFLDRLSALSKIADAD-----ADLLEELKADKA 143
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 568-643 7.52e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 39.62  E-value: 7.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209601078 568 ESDEEIRHLDEEIKELNESNLKIEADMMKLQTQITSMESNLKTIEEENKL-------IEQNNESLLKELAGLSQALISSL 640
Cdd:TIGR04523 360 EKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQkdeqikkLQQEKELLEKEIERLKETIIKNN 439


                  ...
gi 1209601078 641 ADI 643
Cdd:TIGR04523 440 SEI 442
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 567-644 8.95e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.53  E-value: 8.95e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1209601078 567 IESDEEIRHLDEEIKELNESNLKIEADMMKLQTQITSMESNLKTIEEENKLIEQNNESLLKELAGLSQALISSLADIQ 644
Cdd:COG1196   298 ARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELA 375
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 570-692 9.65e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 38.37  E-value: 9.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209601078 570 DEEIRHLDEEIKELNESNLKIEADMMKLQTQITSMESNLKTIEEENKLIE--------------------QNN---ESLL 626
Cdd:COG1579    16 DSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLEleieevearikkyeeqlgnvRNNkeyEALQ 95

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1209601078 627 KELAGLsQALISSLADIQLPQMGPISEQnfEAYVNTLTDMYSNLERDYspecKALLESIKQAVKGI 692
Cdd:COG1579    96 KEIESL-KRRISDLEDEILELMERIEEL--EEELAELEAELAELEAEL----EEKKAELDEELAEL 154
ATG16 pfam08614
Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for ...
 571-619 9.97e-03

Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for eukaryotic cells. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. ATG16 (also known as Apg16) has been shown to be bind to Apg5 and is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway.


Pssm-ID: 462536 [Multi-domain]  Cd Length: 176  Bit Score: 37.60  E-value: 9.97e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1209601078 571 EEIRHLDEEIKELNESNLKIEADMMKLQTQITSMESNLKTIEEENK-LIE 619
Cdd:pfam08614 113 EKLKDREEELREKRKLNQDLQDELVALQLQLNMAEEKLRKLEKENReLVE 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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